Method for early postoperative prevention of acute gastroduodenal ulcers in patients suffering colorectal cancer
SUBSTANCE: invention refers to medicine, namely to surgery, and can be used for the early postoperative prevention of acute gastroduodenal ulcers in patients with colorectal cancer. That is ensured by the preoperative detection of Helicobacter pylori infection. Then for 5-7 preoperative days, amoxicillin in daily dose 2 g and clarithromycin in daily dose 1 g are administered orally.
EFFECT: method provides the prevention of acute gastroduodenal ulcers in the declared group of patients regardless the presence of pathological changes in the upper gastrointestinal mucosa.
The invention relates to medicine, namely surgery, and can be used, in particular, for the prevention of acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period.
From the practice of medicine, namely surgery, there is a method of preventing acute gastroduodenal ulcers by assigning antisecretory drugs. In particular, the use of the intravenous introduction of H2gistaminoblokatorov in the postoperative period under the control of intragastric pH (Scriabin O.N., Verbitsky V.G., M. Kabanov, N. Asanov. Current views on the pathogenesis of acute gastroduodenal ulcers and ways to improve their prevention // Russian journal of gastroenterology, Hepatology, Coloproctology. - 1995. No. 1. - p.36-39).
The disadvantages of this method are:
Used drugs are not effective enough and, according to some researchers, do not reduce the incidence of this complication (Faisy S., Guerot e, Diehl J-L., Iftimovici E., Fagon J-y Clinicaly significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer profylaxis // Intensive Care Medicine. - 2003, - vol.29. No. 8. - P.1306-1313).
The use of drugs that suppress gastric secretion, is associated with the development of a number of complications, which is the most frequent nosocomial pneumonia (Messori a, Trippoli s, Vaiani m, Gormi M, Corrado V. Bleeding and pneumonia in intensive care patients given rnitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomised controlled trials. // BMJ. - 2000. - vol.321, P.1103-1106).
Thus, the described disadvantages do not allow to obtain a specific technical result is a reduction in the incidence of acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period.
Also known a method of preventing acute gastroduodenal ulcers, the essence of which is that patients enter into 100 ml of 40% glucose solution once a day and 200 ml of aminacrine twice a day during the first 3-5 days after surgery (Corigin A.A., Baranchuk, VN, Scriabin O.N., Osipov I.S., Verbitsky VG, Shevchuk IM the Prevention and treatment of stress ulcers // journal of surgery. - 1990. No. 9. - p.41-46).
The disadvantage of this method is the following:
Ingestion of 500 ml of fluid in the first 3 days after surgery on the colon contributes to the development of paresis of the intestine, increases the risk of insolvency intestinal fistula, which does not allow to apply the known method in the postoperative period in individuals with inter-intestinal anastomosis and makes it impossible to use this method in patients with colorectal cancer in the early postoperative period.
These shortcomings do not allow to obtain a specific technical result is a reduction in the incidence of acute gastroduodenal ulcers in patients with colorectal Raco is in the early postoperative period.
The closest method to the present invention is a method of preventing acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period in patent No. 2274455, consisting in the fact that sick for 5-6 days before surgery injected ozonized physiological solution with a single dose of ozone is 42.8 μg of 3 treatments in one daily basis.
The disadvantages of this method are:
the high frequency of acute erosive-ulcerative lesions of the mucous membrane of the stomach and duodenum in patients with colorectal cancer in the postoperative period when using the known method (10%);
- the need to use special medical equipment (medical ozonator "Medozons-BM"), which reduces the availability of this method.
These shortcomings do not allow to obtain a specific technical result is a reduction in the incidence of acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period.
The similarity of the proposed method with the well-known is that they both belong to the surgery and is based on the introduction of drugs into a patient.
The present invention will solve the main task - to reduce the frequency of acute gastroduodenal ulcers in patients with colorectal cancer is the early postoperative period. The essence of the invention is expressed by a set of essential features that are sufficient to provide the technical invention of the result.
The solution of this problem lies in the fact that identify patients infected with Helicobacter pylori, followed by the introduction of them oral amoxicillin at a daily dose of 2 g and clarithromycin daily dose of 1 g for 5-7 days before surgery.
The pathogenesis of acute erosive-ulcerative lesions of the esophagus stomach and duodenum is currently under consideration with the position of the imbalance between the local factors of aggression and protection of the mucous membrane of the digestive tract (Kubyshkin VA, Shishin C.V. Erosive-ulcerative lesions of the upper parts of the gastrointestinal tract in the early postoperative period // Surgery. Consilium medicum. - 2004. No. 1. - P.17-20). Doubtless aggressive factor is Helicobacter pylori. The factors ulcerogenesis due Helicobacter infection include: persistent increase of acid, the development of local inflammatory reactions that damage the gastric mucosa, damage to the endothelium of the microvasculature of the stomach, the change in the number and composition of mucus, slow healing of erosions and ulcers of the mucous membrane of the stomach and duodenum.
Given the above, individuals infected with Helicobacter pylori, are, in glad authors, more susceptible to the formation of acute gastroduodenal ulcers in the early postoperative period, compared with uninfected patients. In connection with this offer in the preoperative period among patients with colorectal cancer to identify patients infected with Helicobacter pylori and carry them with antibacterial treatment as a method of preventing acute gastroduodenal ulcers in patients with colorectal cancer.
The proposed method is as follows. In the preoperative period in patients with colorectal cancer perform esophagogastroduodenoscopy with biopsy. Taken material sent for cytological and histological examination in order to detect Helicobacter pylori. Color cytological preparations Romanovsky-Giemsa. Color histological preparations also perform Romanovsky-Giemsa. In addition, all patients spend immunochromatographic detection of antibodies to Helicobacter pylori in serum. On the basis of three conducted studies of patients infected with Helicobacter pylori. Infected patients per os administered amoxicillin 1 g × 2P per day and clarithromycin 0.5 g × 2P for 5-7 days before surgery.
The proposed method allows to reduce the incidence of acute gastroduodenal ulcers and erosions in the early postoperative period in patients of color is the mental cancer to 5.6% compared to the prototype (10%), does not cause adverse reactions and additional complications.
Just on the subject of Helicobacter pylori infection surveyed 54 people on the basis of immunological laboratory research Institute for the study of leprosy UNIVERSITY. These patients were hospitalized in goose Astrakhan oblast Oncology dispensary in 2007-2008, All examined persons in the preoperative period esophagogastroduodenoscopy was performed to exclude peptic ulcer disease and taking biopsy material. Diagnosis of Helicobacter pylori was performed 3 methods - immunochromatographic detection of antibodies to Helicobacter pylori in serum, cytological and histological examination of biopsy specimens of the gastric mucosa and duodenum. Infected were 36 patients, which accounted for 66.7% of the total surveyed persons From prevention to patients infected with Helicobacter pylori, was administered per os amoxicillin 1 g 2 times a day and clarithromycin 0.5 g 2 times within 5-7 days before surgery. 18 patients without signs Helicobacter infection preventive treatment was not performed. All examined patients at 3 and 7 days of the postoperative period esophagogastroduodenoscopy was performed to identify acute erosive-ulcerative lesions of the esophagus, stomach and duodenum and evaluation effectively.providing preventive treatment. The control group consisted of 123 patients operated in goose Astrakhan oblast Oncology dispensary about colorectal cancer in the period from 2006 to 2007 In the preoperative period, all patients in the control group conducted a survey of the stomach. Data from patients prophylactic treatment is not received.
In the studied group of patients, among whom was identified patients infected with Helicobacter pylori, and held them prophylactic treatment in accordance with the scheme, severe erosion of the stomach was diagnosed in 3 patients, which was 5.6%. Acute gastroduodenal ulcers in patients of this group were not found. In the control group the frequency of erosive and ulcerative lesions of the upper parts of the gastrointestinal tract was 9.8%. Of these erosion was diagnosed in 7 patients and 5.7%, gastroduodenal ulcers - 5 patients (4.1 per cent). However, 6 patients (4,9%) acute gastroduodenal lesion was complicated by bleeding or perforation. Mortality in the control group, due to these complications, was 4.0%, i.e died 5 patients.
The proposed method was successfully tested on 54 patients were examined on the basis of immunological laboratory UHF NEIL UNIVERSITY and operated on for colorectal cancer in goose Astrakhan oblast Oncology dispensary in 2007-2008
Below are the results of the probation.
Example No. 1. Patient A., 54 years old, medical history, No. 3643 Diagnosed with colorectal cancer Art. IV (T4NxM1). Metastases in the liver. Upon receipt of the executed esophagogastroduodenoscopy - erosive-ulcerative lesions not detected. When chromatography revealed antibodies to Helicobacter pylori in serum. The results of cytological and histological examination of the gastric mucosa for the presence of Helicobacter pylori positive. In the preoperative period initiated prevention of the introduction of oral amoxicillin 1 g × 2 times and clarithromycin 0.5 g × 2 times a day, so the daily dose of amoxicillin 2 g, clarithromycin - 1, Treatment was received within 5 days. Treatment discontinued due to the fact that on the 8 day stay in the hospital operated on an emergency regarding the perforation of the tumor. Performed sigmostomia, sanitation and drainage of the abdominal cavity. When a control gastroscopy in the postoperative period of acute erosions and ulcers of the upper gastrointestinal tract have been identified, which testifies to the effectiveness of the proposed method of prevention.
Example No. 2. Patient Century, 70 years, history of No. 6660. Diagnosis of cancer of the rectum Art. IV (T4NxM1). Metastases in the liver. During esophagogastroduodenoscopy in the preoperative period revealed no pathology. A survey on the subject of infection Heliobacter pylori according to the method set forth in example No. 1, is positive. Conducted preventive treatment according to the method described in example No. 1, but for 6 days before surgery. Operation - the imposition of double-barreled colostomy. When control esophagogastroduodenoscopy at 3 and 7 days after surgery erosive-ulcerative lesions of the esophagus, stomach and duodenum was not detected, indicating that the effectiveness of a preventive treatment.
Example No. 3. Patient S., 66 years old, medical history, No. 7696. Diagnosis of cancer of the rising of the Department of colon II In Art. (T4N0M0). During esophagogastroduodenoscopy in the preoperative period revealed no pathology. The results of the survey, according to the method described in example No. 1, concerning the infection of Helicobacter pylori positive. Conducted preventive treatment according to the method described in example No. 1, but within 7 days. Operation - right hemicolectomy with the imposition of retransportation. When a control gastroscopy at 3 and 7 days after surgery acute erosive-ulcerative lesions not detected, which indicates the effectiveness of the proposed method of prevention.
Example No. 4. Patient D., 55 years old, medical history, No. 3352. Diagnosis of cancer of the descending of the Department of colon II In Art. (T4N0M0). During esophagogastroduodenoscopy in the preoperative period revealed no pathology. The survey is and Helicobacter pylori infection, according to the method described in example No. 1, is positive. Received prophylactic treatment according to the method described in example No. 1, for 4 days. The operation is a left hemicolectomy. When a control gastroscopy on the 3rd day of the postoperative period revealed erosion of the duodenum, indicating no positive result.
Example No. 5. Patient E., 67 years old, medical history, No. 3061. Diagnosis of cancer of the rectum II And senior (T3N0M0). During esophagogastroduodenoscopy in the preoperative period revealed no pathology. Screening for Helicobacter pylori infection according to the method described in example No. 1, is positive. Received prophylactic treatment according to the method described in example No. 1, for 8 days. Operation - abdomino-perineal extirpation of the rectum. When a control gastroscopy on the 3rd day of the postoperative period revealed erosion of the antrum, which indicates no positive result.
The advantage of the proposed method is to reduce the frequency of acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period to 5.6%, compared with the prototype (10%). In addition, the proposed method is easy to use. Identification of patients infected with Helicobacter pylori, can be done in different ways, some of which are not Tr is required to endoscopic examination. The cost of preventative treatment is low. The proposed method involves oral medications that can be used at the outpatient stage during examination of the patient. In addition, by reducing the frequency of acute gastroduodenal ulcers in the early postoperative period in patients with colorectal cancer, the proposed method allows to reduce postoperative mortality.
Thus, the authors proposed earlier by anyone not offer a Method of preventing acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period, which can be recommended for use in specialized treatment facilities, providing surgical care to patients with malignant neoplasms of the colon, the country's health system.
A method of preventing acute gastroduodenal ulcers in patients with colorectal cancer in the early postoperative period by introducing medicines into the body of the patient, wherein identifying patients infected with Helicobacter pylori, followed by the introduction of them oral amoxicillin at a daily dose of 2 g and clarithromycin daily dose of 1 g for 5-7 days before surgery.
SUBSTANCE: invention refers to medicine, namely to urology, and can be used for treating complicated purulent pyelonephritis. That is ensured by the surgical intervention and starting from the early postoperative period, bleach solution is administered intravenously and locally. The intravenous introduction of 0.004% bleach solution is carried out once a day at 10 ml of the solution per 1 kg of body weight. Additionally, 0.06% bleach solution is introduced locally intrarenally with a nephrostomic drainage every 12 o'clock in amount 50 ml in divided portions no more than 4 ml for one portion. The therapeutic course is 7 days.
EFFECT: method provides reduced duration of staying in hospital, reduced postoperative complications of septic nature and reduced duration of healing of postoperative wounds in the patients.
SUBSTANCE: invention relates to medicine, namely to vascular surgery and can be used in treatment of patients with varicose disease of lower extremities. For this purpose into proximal end of vein introduced is intravascular catheter with its further movement in the same direction as vein trunks to saphenofemoral fistula under constant ultrasonic control of its movement. After that through catheter introduced is phlebosclerosant, as such solution of ozone on the basis of 0.9-2.0% solution of sodium chloride with ozone concentration 10-25 mg per 1 l of sodium chloride solution. Additionally sclerotherapy of varicose tributaries is carried out by puncture introduction of said solution.
EFFECT: method allows to simplify procedure considerably with simultaneous reduction of trauma due to elimination of carrying out crossectomy and eliminate thromboembolic complications due to effect of concentrated ozone solution on blood rheology.
3 cl, 3 ex
SUBSTANCE: invention relates to medicine, namely to anesthesiology and surgery, and can be used in need of pain relief in post-operation period in patients subjected to laparotomy. For this purpose in formed on the right and on the left along all length of laparotomic wound, at 1.5-2.0 cm distance from its edges, tunnel installed are catheters which have several holes. Through installed catheters solution of local anesthetic is introduced into preperitoneal space every 3 hours during 3 days.
EFFECT: method allows to ensure adequate anesthesia in post-operation period due to possibility to create depot of local anesthetic in preperitoneal space.
2 dwg, 1 ex
SUBSTANCE: invention relates to medicine, namely to surgery, and can be applied for patients with surgical sepsis. For this purpose subcutaneously introduced is sandostatin in dose 100 mkg 5 times per day and roncoleukin in dose 500 thousand IU 1 time per day. Introduction is realised for 2 days and 3 days after operation, as well as in 1 and 2 weeks of post operational period. Simultaneously on the same days during 1 hour hyperbaric oxygenation is carried out with partial pressure of oxygen 1.5-2 atmospheres.
EFFECT: method allows to reduce frequency of fatal outcomes in patients with said pathology due to immunomodelling action, which appears as a result of definite combination of pharmacological medications and hyperbaric oxygenation.
SUBSTANCE: invention refers to antler deer farming. A haemostatic preparation after velvet antler cutting contains burnt potassium alum, anesthesin, microcellulose and camphor in the following ratio, wt %: burnt potassium alum 35-45; anesthesin 14-16; microcellulose 35-45; camphor 4-6. The preparation forms a protective layer with high absorbing, anaesthetising and repellent properties on a section surface.
EFFECT: invention provides effective haemostasis in a velvet antler cut-off and safety of the personnel in the use.
2 tbl, 1 ex
SUBSTANCE: invention relates to medicine, namely to surgery and gastroenterology, and can be used in treatment of patients with acute gastroduodenal hemorrhage. For this purpose fibrogasteroduodenoscopy is performed. Additionally through endoscope canal to source of hemorrhage brought is double-lumen Teflon catheter, through which during 5-7 minutes flow insufflation with ozone-oxygen mixture with concentration 90-100 mg/l and rate of gas flow 250 l/min, is carried out. Excessive waste gas mixture is removed to destructor.
EFFECT: method allows to increase efficiency and safety of endoscopic hemostasis due to ensuring local anti-hypoxia and systemic antioxidant effect with introduction of said mixture in definite mode.
SUBSTANCE: invention relates to medicine, namely, to surgery and intensive therapy, and can be used in treatment of patients with frostbites in pre-reactive and early reactive periods of trauma. For this purpose medications which as active component contain superoxiddismutase are used locally. After that heat-insulating bandage is applied for term not shorter than 24 hours.
EFFECT: method allows to ensure increased efficiency of local treatment of frostbites due to pathogenetic impact aimed at stopping effects of oxidative stress and tissue hypoxia resulting from combined effect of medication, in which superoxiddismutase is used as active substance, and heat-insulating bandage.
1 tbl, 3 ex
SUBSTANCE: invention refers to medicine, namely to surgery and intensive therapy, and can be used in treating endotoxicoses caused by septic conditions. That is ensured by removal of a destruction area to be thereafter sanitised and drained. It is followed with lymphostimulating therapy by introduction of 0.25% Novocaine 60 ml with dissolved 0.1 g of Lydase and 1.0 ml of Pentoxifylline into the interspinous spaces in number of 1-3 injections. Further, discrete plasmapheresis in amount 400 ml for severe patients and 800 ml in moderate patients is applied in number of 1-8 procedures. The lymphostimulating therapy is alternated every second day with lymphotropic extracorporal pharmacoimmunotherapy with using a medicated mixture prepared by incubation of 40-60 ml of the patient's plasma with received plasma of the patient with Roncoleukin in dosage 500-1 million UN and Cefabol in dosage 1 g for 45 min at 37°C. In peritonitis and peritoneal sepsis, the medicated mixture is introduced in the bolus form in the retroperitoneal fat. The destructive processes in the pleural cavity require introduction of said mixture in the axillary cavity.
EFFECT: method provides endotoxin weakening in the bloodstream, intertissue spaces and cavities due to combined multidirectional local and system effect on the lymphoid system.
3 cl, 8 tbl, 3 ex
SUBSTANCE: invention relates to chemical-pharmaceutical industry and deals with obtaining solution for prevention of commissure-formation and creation of method of commissure-formation prevention, applicable in general surgery, in which covered state during surgical intervention is stable and acceptable. Claimed invention represents solution for preventuion of commissure-formation, in which active ingredient is trehalose. In addition, it contains at least one or more means from the following list: antioxidants, chelates, antiseptics, haemostatics, anti-inflammatory preparations, and polysaccharides, mucopolysaccharides, salts of polysaccharides and salts of mucopolysaccharides, which have lubricating properties. Said solution of commissure-formation prevention is presented in any of the following forms: liquid for perfusion, spray, solution for application in form of spraying or evaporation, foam-like aerosol preparation, solution for injection of intravenous liquids, liquid for intravenous introduction.
EFFECT: solution ensures prevention of injury of organs and tissues during operation.
20 cl, 3 ex, 2 tbl
SUBSTANCE: invention relates to medicine, namely to ambulatory surgery and can be used for treatment of nail panaritium. For this purpose from the side of affection made is zigzag cut on the whole height of nail plate in zone of lateral ridge up to unaffected growth zone of nail plate. After sanitisation applied are gauze bandages, soaked with dioxydin solution, which are replaced two times a day till wound purification.
EFFECT: method ensures prevention of formation of rough nail plate growth, prevention of quick plate growth and complications in inflammation focus, quick purification of operation wounds and stopping of inflammatory process in affected finger.
1 ex, 1 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: method of obtaining erythromycin tablets consists in the following: mixture of erythromycin and polyvinylpyrrolidone with molecular weight 10000±2000 with their weight ratio 1:0.125-2 is dissolved in ethanol. Ratio of alcohol and erythromycin and polyvinylpyrrolidone mixture constitutes 1:3-7. After that solution is introduced into device for granulate drying, solvent is removed at temperature 37-41°C. To obtained mass with weight ratio of components 1:2-4 added is mixture of microcrystalline cellulose, starch, lactose, taken with weight ratio 1:2.5-3:6.5-7, respectively. Magnesium stearate is introduced into mixture in amount 2-3% of granulate weight and mixture is tabletted.
EFFECT: claimed method of obtaining erythromycin tablets allows to increase its bioavailability and antibacterial activity.
1 dwg, 3 tbl, 2 ex
FIELD: medicine, veterinary.
SUBSTANCE: invention relates to field of medicine and veterinary, namely to disinfecting preparations against viral and bacterial infections. Preparation, which has virulicidal, bactericidal and disinfecting action, demonstrating activity with respect to A influenza subtype H5N1 virus, Teschen disease virus, virus of rabbit myxoma, African swine fever virus, bacterium Listeria monocytogenes represents chloride-1-hexadecyl-R-(-)-3-oxe-1-1-azoniabicyclo [2.2.2] octane.
EFFECT: invention ensures increase of disinfection efficiency.
SUBSTANCE: invention refers to pharmacology and medicine, and represents an extract in an organic solvent for treating bacterial infection, muscle pain, joint pain, bone pain, burn pain, skin conditions, wounds, inflammations or disorder with an inflammation, prepared by a method including the following stages: (a) mixing of methionine and water, (b) addition of an aqueous hypochloride solution to (a) and stirring of the prepared mixture at temperature in the range 0°C to room temperature, (c) addition of a water-immiscible organic solvent represented by mineral oil or ethyl acetate to (b) and stirring, and (d) separation of a phase of organic solvent.
EFFECT: invention provides effective treatment of bacterial, viral, fungus diseases and inflammations, pain and disorder associated with inflammation, and also skin diseases, herewith without any considerable side effects.
10 cl, 5 ex, 3 tbl
SUBSTANCE: invention relates to novel biologically active compounds of formula , where substitutes R, R1, R2 and R3 are defined in the formula of invention, and can be obtained using a method which involves reaction of corresponding chloroacetamides with a prepared solution of elementary sulphur with morpholine or piperidine, passing the obtained solution of monothiooxamides through a layer of sorbent and then reaction of monothiooxamides with hydrazine-hydrate, reaction of the obtained compound with aldehydes in dimethyl formamide at room temperature and precipitation with methanol which gives good output of the end product.
EFFECT: obtained compounds are highly effective against pathogenic bacteria, are characterised by selectivity and can be used to inhibit type III secretion in pathogenic bacteria.
3 cl, 8 dwg, 1 tbl, 21 ex
SUBSTANCE: invention relates to N-(2-thiazolyl)amide of 2-(2-oxo-3-indolinylidene)hydrazine-4-oxo-4-phenyl-2-butenoic acid of formula: .
EFFECT: obtaining a compound having antibacterial and analgesic activity.
1 cl, 1 tbl, 1 ex
SUBSTANCE: there are developed new prolonged-release pharmaceutical compositions containing ceftiofur crystalline free acid and a carrier containing (i) a modified base oil and (ii) a unmodified base oil.
EFFECT: prolonged release of a bioactive agent.
12 cl, 2 dwg, 6 ex
SUBSTANCE: preparation for treating salmonellosis in young live-stock animals contains, wt %: colistin sulphate 4.0-6.0; tylosin base 4.0-6.0; sodium pyrosulphite 0.32; benzyl alcohol 4.0; water for injections 15.0; 1,2-propyleny glycol - to 100.0.
EFFECT: higher effectiveness of treating salmonellosis in young live-stock animals.
14 tbl, 5 ex
SUBSTANCE: disclosed method is realised by dissolving commercial grade vancomycin hydrochloride in water, ultrafiltration of the solution with a membrane having norminal retention lower than 30000 Da, preferably of 10000 Da. The purified solution is preferably concentrated via reverse osmosis and then lyophilised at optimum pressure and temperature to obtain white powder.
EFFECT: method enables to obtain white powder which remains white after storage for a certain period of time.
5 cl, 3 ex
SUBSTANCE: invention relates to N-substituted derivatives of oxamic acid thiohydrazides of general formula: , where R and R1 denote H, unsubstituted or substituted Het, phenyl, Alk, wherein substitutes can be Alk, Hal, CF3, COOR3, SR3, or R+R1=C2H4OC2H4; R2 denotes H, Alk, OR3, Hal, where R3=Alk; Het denotes a 5- or 6-member ring which contains one or two heteroatoms selected from N and S. The invention also relates to a method for synthesis of said compounds.
EFFECT: obtaining novel compounds which exhibit antibacterial activity and can be used as antibacterial agents for inhibiting pathogenic bacteria, including Chlamydia.
4 cl, 21 ex
SUBSTANCE: group of inventions relates to field of veterinary medicine. Combined vaccine against dog's leptospirosis contains preparation of Leptospira cells from Leptospira bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae and Leptospira pomona and a carrier. Quantity of each Leptospira strain in combined vaccine is in the range of nearly 100-3500 nephelometric units per a dose of vaccine. Combined vaccine for immunisation of dogs against dogs' pathogens additionally contains attenuated strain Snyder Hill of dogs plague virus (CD), attenuated strain Manhattan of adenovirus of dogs of 2 type (CAV-2), attenuated strain of virus NL-CPI-5 of dogs parainfluenza (CPI), attenuated strain NL-35-D of dogs' parvovirus (CPV) and carrier, where said virus CD, CAV-2, virus CPI and CPV are in the range from ot 102 to 109 TCID50 (inflectional dose with 50% cytopathic effect in tissue culture) per a dose. Method of dog's protection against leptospirosis and other pathogens includes introduction to a dog of said above combined vaccines in therapeutically effective quantity.
EFFECT: vaccines and method have high efficiency, are harmless.
15 cl, 4 dwg, 49 tbl, 6 ex
SUBSTANCE: invention relates to medicine, namely to pediatrics, gastroenterology. Method includes introduction of proton pump inhibitor and prokinetics. As proton pump inhibitor, ultop in dose 10 mg is introduced 2 times per day. As prokynetic, motilium is introduced in dose 1 tablet 2 times per day. Additionally in period from 9.00 to 10.00 o'clock pysiotherapy is carries out by exposure to sinusoidal modulated currents. Impact is carried out with modulation depth 75-100%, frequency 50-75 Hz. Exposure is performed by means of electrodes applied transversally in epigastric area and lower thoracic spine. Course includes 8-10 procedures. In period from 10.00 to 11.00 reflexotherapy is carried out by massage of vacuum jar alternating it with massage by means of needle roller on urinary bladder duct paravertebrally, duration of impact is 2-3 minutes. After that, point massage of corporal C 7, E 25, E 36, F 3, F 6, GI 4, GI 11, MC 6, P 7, RP 4, RP 6, V 18, V 19, V 20, V 21, V 23, V 25, VB 20, VB 34, and auricular 51, 55, 83, 86, 87, 91, 95, 97, 100 points is carried out. Impact duration is 15-20 minutes, course includes 10-12 sessions. After that tsubotherapy is carried out by application of balls by means of hypoallergic plaster on corporal E 36, GI 4, RP6 and auricular 85, 86, 87 points. Points are periodically massaged during day every 1.5-2 hours, for 1-2 minutes with each ball. In period from 11.00 to 12.00 o'clock music aromatherapy is performed. Essential oils of lemon, tea tree jumper, live nature sounds and fragments of classical music are used. Course includes 10-14 sessions. Also phytotherapy is performed during 10-14 days by introduction of phytococktails "Biorhythm RS", "Biorhythm DS" in day dose 10-30 drops inside 15-20 minutes before meal, taking into account chronotype.
EFFECT: method improves clinic-endoscopic and psychosomatic statuses of patients, increases remission duration.
2 tbl, 2 ex, 2 dwg