Amide compounds and thrombopoietin receptor activators

FIELD: chemistry.

SUBSTANCE: in formula (1) A is a nitrogen atom or CH; when A is a nitrogen atom, B is NR9 (where R9 is a C1-10alkyl group), when A is CH, B is a sulphur atom, R1 is a phenyl group (where the phenyl group is substituted with one or more substitutes selected from a group consisting of halogen atoms, C1-10alkyl group and C1-10alkoxy groups (where C1-10alkyl groups and C1-10alkoxy groups are not substituted of substituted with one or more halogen atoms)); L1 is a bond; X is OH; R2 is a C1-6alkyl group; L2 is a bond; L3 is NH; L4 is a bond or NH; Y is an oxygen atom or sulphur atom; R3 is a thienyl group (where the thienyl group is substituted with CONR29R30 (where R29 is hydrogen or a C1-10alkyl group, and R30 is an amino group (where the amino group is not substituted or substituted with a pyridyl group), mono- or di-C1-10alkylamino group, N-methylpiperzinyl group, piperidine group, morpholine group or C1-10alkyl group (C1-10alkyl group is substituted with one or more substitutes selected from a group consisting of a carboxyl group, carbamoyl groups, pyrroldinyl groups, tetrahydrofuryl groups or morpholine groups) or R29 and R30 together denote -(CH2)m3-G-(CH2)m4- (where G is CR31R32 (where R31 is a hydrogen atom and R32 is a C1-10alkylcarbonylamino group or pyrrolidinyl group) and each of m3 and m4 is independently equal to an integer from 0 to 5 provided that m3+m4 equals 3, 4 or 5), or NR29R30 as a whole denotes a piperidine group or pyrrolidinyl group (where the piperidine group or pyrrolidinyl group is substituted with two substitutes independently selected from a group consisting of: hydroxyl groups and C1-10alkoxy groups) or 2-(4-oxopyrridin-1(4H)-yl)acetyl group), phenyl group (where the phenyl group is substituted with one substitute selected from a group consisting of C1-10alkyl groups, C1-10alkylcarbonyl groups and C1-10alkylaminocarbonyl groups, (where C1-10alkyl group, C1-10alkylcarbonyl group and C1-10alkylaminocarbonyl group are substituted with one or two substitutes selected from a group consisting of hydroxyl groups, carboxyl groups and carbamoyl groups)), phenyl group (where the phenyl group is substituted with one C1-10alkylaminocarbonyl group or one halogen atom), dihydrobenzo[1,4]dioxine group or benzo[1,4]oxazine group. The invention also relates to a medicinal agent containing the disclosed compound as an active ingredient and to a thromopoeitin receptor activator which is a formula (1) compound.

EFFECT: disclosed compounds have thrombopoietin receptor agonist properties.

8 cl, 11 tbl, 128 ex

 

The invention relates to preventive, therapeutic and improving agents having affinity and agonistic effect on the receptor thrombopoetin against diseases for which treatment is effective activation of the receptor thrombopoetin. More specifically, it relates to pharmaceutical compositions containing compounds that increase the number of platelets by stimulating the differentiation and proliferation of hematopoietic stem cells, precursor cells megakaryocytes and megakaryocytes, or compounds that cause therapeutic angiogenesis, or compounds with antiarteriosclerotic action, which stimulate differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells.

Thrombopoetin is a cytokine that consists of 332 amino acids, which indirectly, through its receptors enhances the production of platelets by stimulating the differentiation and proliferation of hematopoietic stem cells, megakaryocytes and precursor cells megakaryocytes, and, therefore, is promising as a medicinal substance against hematologic disorders. Recent reports that it stimulates the differentiation and proliferation of vascular endothelialisation and endothelial precursor cells, led to the emergence of prospects for therapeutic angiogenesis, treatment of antiarteriosclerotic and prevention of cardiovascular diseases (for example, non-patent document 1, non-patent document 2 and non-patent document 3).

Biologically active substances which are known at the present day, influencing the receptor thrombopoetin, regulates the production of platelets, in addition to thrombopoetin include low molecular weight peptides having affinity to the receptor thrombopoetin (for example, patent document 1, patent document 2, patent document 3 and patent document 4).

In search of low-molecular ones connections, which are mediated through the receptor thrombopoetin increase the production of platelets, were published reports of low molecular weight compounds with affinity to the receptor thrombopoetin (for example, patent documents 5 to 25).

1. Application filed Hokuriku Seiyaku Co., Ltd., related to 1,4-benzodiazepine derivatives (patent documents 5 and 6).

2. International published patent application filed by Shionogi & Co., Ltd. (patent documents 7-10).

3. International published patent application filed by SmithKline Beecham Corp (patent documents 11-19).

4. Japanese published patent application filed by Torii Pharmaceutical Co., Ltd. (the patent is the first document 20).

5. International published patent application filed by Roche Diagnostics GMBH (patent document 21).

6. International published patent application filed by Yamanouchi Pharmaceutical Co., Ltd. (patent documents 22 and 23).

7. Japanese published patent application filed by Japan Tabacco Inc (patent document 24).

8. Japanese published patent application filed by Nissan Chemical Industries, Ltd. (patent documents 25 and 26).

Patent document 1 JP-A-10-72492

Patent document 2 WO 96/40750

Patent document 3 WO 96/40189

Patent document 4 WO 98/25965

Patent document 5 JP-A-11-1477

Patent document 6 JP-A-11-152276

Patent document 7 WO 01/07423

Patent document 8 WO 01/53267

Patent document 9 WO 02/059099

Patent document 10 WO 02/059100

Patent document 11 WO 00/35446

Patent document 12 WO 00/66112

Patent document 13 WO 01/34585

Patent document 14 WO 01/17349

Patent document 15 WO 01/39773

Patent document 16 WO 01/21180

Patent document 17 WO 01/89457

Patent document 18 WO 02/49413

Patent document 19 WO 02/085343

Patent document 20 JP-A-2001-97948

Patent document 21 WO 99/11262

Patent document 22 WO 02/062775

Patent document 23 WO 03/062233

Patent document 24 JP-A-2003-238565

Patent document 25 WO 04/033433

Patent document 26 WO 04/108683

Non-patent document 1 Microvasc. Res., 1999: 58, p.108-113

Non-patent document 2 Circ. Res., 199: 84, p.785-796

Non-patent document 3 Blood 2001:98, p.71a-72a

Thrombopoetin and low molecular weight peptides having affinity to the receptor thrombopoetin probably easily broken down in the gastrointestinal tract and, as a rule, are not suitable for oral administration. As for thrombopoetin, reported the appearance of antibodies to thrombopoietin.

In addition, despite the alleged oral use of low molecular weight ones connections, real medicinal substance is not on sale.

Therefore, there is a need for low molecular weight compounds for oral administration, with high affinity and agonistic effect on the receptor thrombopoetin, as a preventive, therapeutic and improving agents against diseases for which treatment is effective activation of the receptor thrombopoetin. More specifically, there is a need for low molecular weight compounds, which can serve as agents that increase the number of platelets, or agents that increase the number of other blood cells by stimulating the differentiation and proliferation of hematopoietic stem cells, precursor cells megakaryocytes and megakaryocytes, or low molecular weight compounds, which is may be used in therapeutic angiogenesis or as a prophylactic and therapeutic agent against atherosclerosis by stimulating endothelial cells and endothelial progenitor cells.

The authors of the present invention conducted extensive research in search of low molecular weight compounds having affinity and agonistic effect on the receptor thrombopoetin, and as a result have found that the compounds of the present invention have a high affinity and agonist activity, through which they demonstrate a strong effect in increasing the number of platelets by stimulating the differentiation and proliferation of progenitor cells megakaryocytes and megakaryocytes. The present invention based on this discovery.

Namely, the present invention relates to

1. The compound represented by formula (1):

where A represents a nitrogen atom or CR4(where R4represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol group or a C2-6alkenylphenol group), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or two C2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, tzia is Gruppo, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10al the ilen groups (C 1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), SO2R5, SOR5or COR5(where R5PR is dstanley a hydroxyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik g the SCP, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or NR6R7(where each of R6and R7independently represent a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, Csub> 2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups may be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or R6and R7taken together, means -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic is a sigroup, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkyls is boilershop, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5)))),

B represents an oxygen atom, a sulfur atom or NR9(where R9represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino is p, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups could the t to be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)) (provided that when A represents a nitrogen atom, B is not NH),

R1represents a C2-14aryl group (C2-14the aryl group may be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic and C1-10alkoxycarbonyl group optionally can be substituted one is m or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups (C2-14aryl group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl the groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or two substituents selected from the group consisting of formyl group, a C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)))),

L1represents a bond, CR0 R11(where each of R10and R11independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms)), an oxygen atom, a sulfur atom or NR12(where R12represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group and Csub> 2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)),

X is a OR13, SR13or NR14R15(where R13represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group or a C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkylarene the other group optionally can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), and each of R14and R15independently represents a hydrogen atom, a formyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C 1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)),

R2represents a hydrogen atom, formyl g is the SCP, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or a few is Kimi halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy),

L2represents a bond, CR34R35(where each of R34and R35independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms)), an oxygen atom, a sulfur atom or NR16(where R16represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group may not necessarily be the Deputy is received by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydro is a strong group, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)),

L3represents a bond, CR17R18(where each of R17and R18independently represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C 2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), an oxygen atom, a sulfur atom or NR19(where R19represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted one who does more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydro is a strong group, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)),

L4represents a bond, CR20R21(where each of R20and R21independently represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14 aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), an oxygen atom, a sulfur atom or NR22(where R22represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted one or not is how many deputies, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydro is a strong group, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)),

Y represents an oxygen atom, a sulfur atom or NR23(where R23represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C 1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), or C2-14aryl group (C2-14the aryl group may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and

R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1represents a hydrogen atom, hydroxyl group, protected hydroxyl group, amino group, Tilney group, a nitrogroup, cyano, halogen atom, carboxyl group, karbamoilnuyu group, sulfamoyl group, alphagroup, formyl group, 1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10alkylcarboxylic group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10Tolkalina group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, Aminov the SCP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)) and one or more substituents independently represented as W1(CW2W3)mW4(where W1 24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10alkylarene the other group optionally can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino shall Rupp, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group, amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitrogen is PP, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protect the protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14 aryloxy) and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents the ATO is hydrogen, C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9GE is eroticline group may be substituted by one or more substituents, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more atom of the mi by halogen or by one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfa is oilrich groups, of sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C-14 aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6sceneline groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy the PP (C 2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or substituted C2-9heterocyclic group (substituted C2-9heterocyclic group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, NITR the groups, of cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkitab is laminography, amino, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V 1(where V1is the same as defined above), and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups and C2-6etkinlik groups (C1-6alkyl group, a C2-6alkeneamine group and C2-6alkyline group optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents independently represented as-V2(where V2is the same as V1and V1are the same as defined above) and-W5(where W5represents the SO2R42, SOR42, COR42(where R42represents a hydrogen atom, a hydroxyl group, or NR43R44, R43is the same as R6, R44is the same as R7and R6and R7are as defined above), or W4and W4is the same as defined above))), C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented and as-V 1(where V1is the same as defined above), and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group independently substituted by one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from C2-9heterocyclic groups (C2-9heterocyclic group optionally substituted by one or more substituents independently represented as-V3(where V3is the same as V1and V1is as defined above))))C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1is the same as defined above), and one or more substituents, selected from the group comprised the overall value of C 1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from the group consisting of amino groups (amino groups substituted C1-10alkyl group, (C1-10alkyl group optionally substituted by one or more substituents independently represented as-V3(where V3is the same as V1and V1is the same as defined above)) and C2-9heterocyclic group or a C2-14aryl group (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V4(where V4is the same as V1and V1is the same as defined above))), amino groups, mono - or di-C1-10and what of killingray, C1-10alkoxygroup, C1-10thioalkyl groups, C1-10alkylsulfonyl groups, sulfanilic groups, sulfinyl groups and tylnej groups (amino, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl group and tirinya group optionally substituted by one or more C2-9heterocyclic groups or one or more C2-14aryl groups (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V5(where V5is the same as V1and V1is as defined above)))))or C2-14substituted aryl group, (C2-14substituted aryl group optionally may be substituted by one or more substituents independently represented as-V1(where V1is the same as defined above)); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

2. The compound according to claim 1, in which A represents a nitrogen atom, B represents a sulfur atom; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

3. With the unity according to claim 1, in which A represents a nitrogen atom, B represents an oxygen atom; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

4. The compound according to claim 1, in which A represents a nitrogen atom, and B represents NR9group differs from NH (where R9represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups and C 2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl GRU is p, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

5. The compound according to claim 1, in which m represents CR4(where R4represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol group or a C2-6alkenylphenol group), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or two C2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, a cyano, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino the PU, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, CT is oxolinic groups, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), SO2R5, SOR5or COR5(where R5represents a hydroxyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10al the ilen group, C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10and what of kilcarbery, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or NR6R7(where each of R6and R7independently represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkylen the group, C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups,halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or R6and R7taken together, means -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represent a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted for the one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydro is a strong group, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5))))and B represents an oxygen atom; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

6. The compound according to claim 1, in which A is as defined in claim 5, and B is a sulfur atom; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

7. The compound according to claim 1, in which A is as defined in claim 5, and B represents NR9(where R9represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, and the Ohm halogen free, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and the and C 2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

8. The compound according to any one of items 1 to 7, where L1that is the link; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

9. The compound according to any one of items 1 to 8, in which L2that is the link; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

10. The compound according to any one of items 1 to 9, in which L3represents NR19(where R19represents the t of a hydrogen atom, hydroxyl group, a formyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optional the part may be substituted by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

11. The compound according to any one of items 1 to 10, where L3represents NH; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

12. The connection of claim 10, in which L4represents NR22(where R22represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6alkene is supplemented flax group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, ATO is s halogen free, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

13. Connection by claim 11, in which L4is the same as defined in item 12; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

14. The compound of claim 10 or claim 11, in which L4represents NH; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

15. The compound of claim 10 or claim 11, in which L4that is the link; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

16. The compound according to any one of PP-15, in which Y represents an oxygen atom; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

17. The compound according to any one of PP-15, in which Y represents a sulfur atom; tautomer, prodrug or pharmaceutically acceptable salt of the specified connection is of or MES.

18. The connection clause 16, in which X represents a hydroxyl group; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

19. The connection 17 in which X represents a hydroxyl group; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

20. Connection P16 or p, in which R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1,2 or 3) an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10al is incorporating, amino, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic is Gruppo, C1-10alkylaminocarbonyl group, C2-9heterocyclic group, amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyine the groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic the St group (C 1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14 aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optional the part may be substituted by one or more substituents, selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or NESCO is Kimi halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

21. The connection 17 or 19, in which R3is such as defined in claim 20; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

22. Connection article 16, or 18, in which R3represents a C2-14aryl group (where C2-14aryl group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitrogen is PP, of cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represent a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28- NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is the battle of CR 31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic the group, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be Emesene one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or C2-9heterocyclic gr is the PAP may be substituted by one or more substituents, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups,C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups,C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group,C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted onemile more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

23. The connection 17 or 19, where R3is such as defined in article 22; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

24. Connection article 16, or 18, where R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more C is Mascitelli, selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group or a C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30 as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted one or more replacement is a Fort worth, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-101-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or substituted C2-9heterocyclic group (substituted C2-9heterocyclic group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonyl is aminogruppy, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, NIT is AGroup, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

25. The connection 17 or 19, in which R3is as defined in paragraph 24; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

26. Connection article 16, or 18, in which R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented by C1-6alkyl groups (C1-6alkyl group optionally substituted by one or more substituent and, selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents independently represented as-V1(where V1is such as defined in claim 1) and-W5(where W5represents the SO2R42, SOR42, COR42(where R42represents a hydroxyl group or NR43R44and R43and R44are as defined in claim 1), or W4where W4is such as defined in claim 1))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

27. The connection 17 or 19, in which R3is the same as defined in p; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

28. Connection article 16, or 18, where R3represents a substituted C2-14aryl group (substituted C2-14aryl group optionally may be substituted by one or more substituents independently represented as-V1(where V1is such as defined in claim 1)); tautomer, prodrug or pharmaceutically reception who will be the salt of the compounds or its MES.

29. The connection 17 or 19, in which R3is the same as defined in p; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

30. Connection article 16, or 18, in which R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride group, a C1-10forelcosure, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents selected from the group consisting of hydrogen, C1-10alkyl is groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy, and one or more substituents selected from C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups,carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected who's hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

31. The connection 17 or 19, in which R3is such as defined in article 30; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

32. Connection article 16, or 18, in which R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride group, a C1-10forelcosure, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more groups selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10and killalpaninna group optionally substituted by one or more substituents, selected from the group consisting of amino groups (amino groups substituted C1-10alkyl group, and C2-9heterocyclic group or a C2-14aryl group (C2-9heterocyclic group, and C2-14aryl group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), amino groups, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl groups, C1-10alkylsulfonyl groups, sulfanilic groups, sulfinyl groups and tylnej groups (amino, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl the e group and tirinya group optionally substituted by one or more C 2-9heterocyclic groups or one or more C2-14aryl groups (C2-9heterocyclic group, and C2-14aryl group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))); tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

33. The connection 17 or 19, in which R3is the same as defined in p; tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

34. Drug containing as an active ingredient the compound according to any one of items 1 to 33, tautomer, prodrug or pharmaceutically acceptable Aleksandrovo connection or MES.

35. Activator receptor thrombopoetin containing as an active ingredient the compound according to any one of items 1 to 33, tautomer, prodrug or pharmaceutically acceptable salt of the compounds or its MES.

36. Preventive, therapeutic or improving agent against diseases for which treatment is effective activation of the receptor thrombopoetin, which contains as an active ingredient the compound according to any one of items 1 to 33, tautomer, prodrug or pharmaceutically acceptable salt of the specified activator or MES.

37. The agent that increases the number of platelets containing as an active ingredient the compound according to any one of items 1 to 33, tautomer, prodrug or pharmaceutically acceptable salt of the specified activator or MES.

BRIEF DESCRIPTION of DRAWINGS

Figure 1 shows the rapid increase in UT7/EPO-mpl cells when the stimulation compound of the present invention (Example 2 synthesis).

Figure 2 shows the rapid growth of cells, UT7/EPO when the stimulation compound of the present invention (Example 2 synthesis).

In the present invention, “n” denotes normal, “ISO” refers to the isomer, “Deuteronomy” means secondary, “t” means tertiary, “cyclo” denotes a cyclic, “o” means ortho, “m” denotes meta “p” denotes a pair, “Ph” means phenyl, “Py” denotes pyridyl, Naphthyl” refers to a naphthyl, “Me” means methyl, “Et” means ethyl, “Pr” means propyl, “Bu” represents butyl, “Ac” means acetyl.

The following is an explanation of the elements in the respective substituents R1-R44.

The halogen atom may be a fluorine atom, chlorine atom, bromine atom or iodine atom.

C1-3the alkyl group may be linear, branched, or may be a C3cycloalkyl group, and methyl, ethyl, n-propyl, isopropyl and cyclopropyl etc.

C1-6the alkyl group may be linear or branched C3-6cycloalkyl group and, in addition to the above-mentioned groups may represent n-butyl, isobutyl, sec-butyl, tert-butyl, cyclobutyl, 1-methylcyclopropyl, 2-methylcyclopropyl, n-pentyl, 1-methyl-n-butyl, 2-methyl-n-butyl, 3-methyl-n-butyl, 1,1-dimethyl-n-propyl, 1,2-dimethyl-n-propyl, 2,2-dimethyl-n-propyl, 1-ethyl-n-propyl, cyclopentyl, 1-methylcyclobutene, 2-methylcyclohexyl, 3-methylcyclobutene, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1-ethylcyclopropane, 2-ethylcyclopropane, n-hexyl, 1-methyl-n-pentyl, 2-methyl-n-pentyl, 3-methyl-n-pentyl, 4-methyl-n-pentyl, 1,1-dimethyl-n-butyl, 1,2-dimethyl-n-butyl, 1,3-dimethyl-n-butyl, 2,2-dimethyl-n-butyl, 2,3-dimethyl-n-butyl, 3,3-dimethyl-n-butyl, 1-ethyl-n-butyl, 2-ethyl-what-butyl, 1,1,2-trimethyl-n-propyl, 1,2,2-trimethyl-n-propyl, 1-ethyl-1-methyl-n-propyl, 1-ethyl-2-methyl-n-propyl, cyclohexyl, 1-methylcyclopentanol, 2-methylcyclopentene, 3-methylcyclopentene, 1-ethylcyclohexyl, 2-ethylcyclohexyl, 3-ethylcyclohexyl, 1,2-dimethylcyclobutyl, 1,3-dimethylcyclobutyl, 2,2-dimethylcyclobutyl, 2,3-dimethylcyclobutyl, 2,4-dimethylcyclobutyl, 3,3-dimethylcyclobutyl, 1-n-propylcyclohexyl, 2-n-propylcyclohexyl, 1-isopropylcyclohexane, 2-isopropylcyclohexane, 1,2,2-trimethylpropyl, 1,2,3-trimethylpropyl, 2,2,3-trimethylpropyl, 1-ethyl-2-methylcyclopropyl, 2-ethyl-1-methylcyclopropyl, 2-ethyl-2-methylcyclopropyl, 2-ethyl-3-methylcyclopropyl etc.

C1-10the alkyl group may be linear or branched C3-10cycloalkyl group and, in addition to the above-mentioned groups may be a 1-methyl-1-ethyl-n-pentyl, 1-heptyl, 2-heptyl, 1-ethyl-1,2-dimethyl-n-propyl, 1-ethyl-2,2-dimethyl-n-propyl, 1-octyl, 3-octyl, 4-methyl-3-n-heptyl, 6-methyl-2-n-heptyl, 2-propyl-1-n-heptyl, 2,4,4-trimethyl-1-n-pentyl, 1 nonyl, 2-nonyl, 2,6-dimethyl-4-n-heptyl, 3-ethyl-2,2-dimethyl-3-n-pentyl, 3,5,5-trimethyl-1-n-hexyl, 1-decyl, 2-decyl, 4-decyl, 3,7-dimethyl-1-n-octyl, 3,7-dimethyl-3-n-octyl etc.

C2-6Alchemilla group or may be ethinyl, 1-PROPYNYL, 2-PROPYNYL, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-PROPYNYL, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-penten is l, 1-methyl-2-butenyl, 1-methyl-3-butynyl, 2-methyl-3-butenyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-PROPYNYL, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 3-methyl-1-pentenyl, 3-methyl-4-pentenyl, 4-methyl-1-pentenyl, 4-methyl-2-pentenyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butinyl, 1-ethyl-3-butynyl, 1-n-propyl-2-PROPYNYL, 2-ethyl-3-butynyl, 1-methyl-1-ethyl-2-PROPYNYL, 1-isopropyl-2-PROPYNYL and the like

C2-6Alchemilla group can be linear or branched C3-6cycloalkenyl group can represent and ethynyl, 1-propenyl, 2-propenyl, 1-methyl-1-ethynyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, 1-tilateral, 1-methyl-1-propenyl, 1-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-n-propylidene, 1-methyl-1-butenyl, 1-methyl-2-butenyl, 1-methyl-3-butenyl, 2-ethyl-2-propenyl, 2-methyl-1-butenyl, 2-methyl-2-butenyl, 2-methyl-3-butenyl, 3-methyl-1-butenyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1-isopropylidene, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2-propenyl, 1-cyclopentenyl, 2-cyclopentenyl, 3-cyclopentenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 1-methyl-2-pentenyl, 1-methyl-3-pentenyl, 1-methyl-4-pentenyl, 1H-butylether, 2-methyl-1-pentenyl, 2-methyl-2-pentenyl, 2-methyl-3-pentenyl, 2-methyl-4-pentenyl, 2-n-propyl-2-propenyl, 3-methyl-1-pentenyl, 3-methyl-2-pentenyl, 3-methyl-3-pentenyl, 3-methyl-4-pentenyl, 3-ethyl-3-butenyl, 4-methyl-1-pentenyl, 4-methyl-2-pentenyl, 4-methyl-3-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1-methyl-2-ethyl-2-propenyl, 1-second-butylether, 1,3-dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 1-isobutylene, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 2-isopropyl-2-propenyl, 3,3-dimethyl-1-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 1-n-propyl-1-propenyl, 1-n-propyl-2-propenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-tert-butylether, 1-methyl-1-ethyl-2-propenyl, 1-ethyl-2-methyl-1-propenyl, 1-ethyl-2-methyl-2-propenyl, 1-isopropyl-1-propenyl, 1-isopropyl-2-propenyl, 1-methyl-2-cyclopentenyl, 1-methyl-3-cyclopentenyl, 2-methyl-1-cyclopentenyl, 2-methyl-2-cyclopentenyl, 2-methyl-3-cyclopentenyl, 2-methyl-4-cyclopentenyl, 2-methyl-5-cyclopentenyl, 2-methylene-cyclopentyl, 3-methyl-1-cyclopentenyl, 3-methyl-2-cyclopentenyl, 3-methyl-3-cyclopentenyl, 3-methyl-4-cyclopentenyl, 3-methyl-5-cyclopentenyl, 3-methylene-cyclopentyl, 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl etc.

C2-9heterocyclic gr the PLR can be heterogenities or condensed heterobicyclic group, consisting of at least one atom, optionally selected from nitrogen atom, oxygen atom and sulfur atom, and from 2-9 carbon atoms, and, in particular, can represent:

Nitrogen-containing C2-9heterocyclic group may constitute from among the above groups, heterogenities or condensed heterobicyclic group containing at least one nitrogen atom, may contain at least one atom independently selected from oxygen atom and sulfur atom, and contains 2 to 9 carbon atoms, and, in particular, can represent:

Substituted C2-9heterocyclic group may be a from C2-9heterocyclic groups and nitrogen-containing C2-9heterocyclic groups, heterogenities or condensed heterobicyclic group which does not contain nitrogen atoms and has one or three carbonyl groups or thiocarbonyl groups as ring consisting of carbon atoms and, in particular, represents:

C2-14aryl group may be a C6-14aryl group containing no heteroatoms as atoms constituting the ring, or C2-9aromatic heterocyclics the second group, and C2-9aromatic heterocyclic group may be a 5-7-membered C2-6heterogenities group or an 8-10-membered condensed C5-9heterobicyclic group containing 1-3 oxygen atom, nitrogen atom or sulfur atom, alone or in combination.

C6-14aryl group, not containing heteroatoms, may be a phenyl group, 1-indenolol group, 2-indenolol group, 3-indenolol group, 4-indenolol group, 5-indenolol group, 6-indenolol group, 7-indenolol group, α-naftalina group, β-naftalina group, 1-tetrahydronaphthyl group, 2-tetrahydronaphthalene group, 5-tetrahydronaphthyl group, 6-tetrahydronaphthyl group, o-biphenylene group, m-biphenylene group, p-biphenylene group, 1-untilnow group, 2-untilnow group, 9-untilnow group, 1-phenanthroline group, 2-phenanthroline group, 3-phenanthroline group, 4-phenanthroline group, 9-phenanthroline group, etc.

5-7-membered C2-6heterophilically group can be a 2-thienyl group, 3-thienyl group, 2-follow group, 3-follow group, 2-pyranyloxy group, 3-pyranyloxy group, 4-pyranyloxy group, 1-pyrrolidinyl group, 2-pyrrolidinyl group, 3-pyrrolidinyl group, 1-imidazolidinyl group, 2-imidazolidinyl group, 4-imidazolidinyl GRU is sing, 1-pyrazolidine group, 3-pyrazolidine group, 4-pyrazolidine group, 2-thiazolidine group, 4-thiazolidine group, 5-thiazolidine group, 3-isothiazolinone group, 4-isothiazoline group, 5-isothiazolinone group, 2-oxazolidinyl group, 4-oxazolidinyl group, 5-oxazolidinyl group, 3-isoxazolyl group, 4-isoxazolyl group, 5-isoxazolyl group, 2-pyridyloxy group, 3-pyridyloxy group, 4-pyridyloxy group, 2-personilnya group, 2-pyrimidinyl group, 4-pyrimidinyl group, 5-pyrimidinyl group, 3-pyridazinyl group, 4-pyridazinyl group, 2-1,3,4-oxadiazolyl group, 2-1,3,4-thiadiazolyl group, 3-1,2,4-oxadiazolyl group, 5-1,2,4-oxadiazolyl group, 3-1,2,4-thiadiazolyl group, 5-1,2,4-thiadiazolyl group, a 3-1,2,5-oxadiazolyl group, a 3-1,2,5-thiadiazolyl group, etc.

8-10-membered condensed C5-9heterocyclic group may be a 2-benzofuranyl group, 3-benzofuranyl group, 4-benzofuranyl group, 5-benzofuranyl group, 6-benzofuranyl group, 7-benzofuranyl group, 1-isobenzofuranyl group, 4-isobenzofuranyl group, 5-isobenzofuranyl group, 2-benzothiazoline group, 3-benzothiazoline group, 4-benzothiazoline group, 5-benzothiazoline group, 6-benzothiazoline group, 7-benzothiazoline is the Rupp, 1-isobenzofuranyl group, 4-isobenzofuranyl group, 5-isobenzofuranyl group, 2-romanello group, 3-romanello group, 4-romanello group, 5-romanello group, 6-romanello group, 7-romanello group, 8-romanello group, 1-indolizinyl group, 2-indolizinyl group, 3-indolizinyl group, 5-indolizinyl group, 6-indolizinyl group, 7-indolizinyl group, 8-indolizinyl group, 1-isoindolyl group, 2-isoindolyl group, 4-isoindolyl group, 5-isoindolyl group, 1-indolering group, 2-indolering group, 3-indolering group, 4-indolering group, 5-indolering group, 6-indolering group, 7-indolering group, 1-indazolinone group, 2-indazolinone group, 3-indazolinone group, 4-indazolinone group, 5-indazolinone group, 6-indazolinone group, 7-indazolinone group, 1-parinello group, 2-parinello group, 3-parinello group, 6-parinello group, 7-parinello group, 8-parinello group, 2-pinolillo group, 3-pinolillo group, 4-pinolillo group, 5-pinolillo group, 6-pinolillo group, 7-pinolillo group, 8-pinolillo group, 1-izohinolinove group, 3-izohinolinove group, 4-izohinolinove group, 5-izohinolinove group, 6-izohinolinove group, 7-izohinolinove group, 8-izohinolinove group, 1-phthalazinone group, 5-f is aleshinloye group, 6-talinolol group, 1-2,7-naphthyridinone group, 3-2,7-naphthyridinone group, 4-2,7-naphthyridinone group, 1-2,6-naphthyridinone group, 3-2,6-naphthyridinone group, 4-2,6-naphthyridinone group, 2-1,8-naphthyridines group, 3-1,8-naphthyridines group, 4-1,8-naphthyridines group, 2-1,7-naphthyridinone group, 3-1,7-naphthyridinone group, 4-1,7-naphthyridinone group, 5-1,7-naphthyridinone group, 6-1,7-naphthyridinone group, 8-1,7-naphthyridinone group, 2-1,6-naphthyridinone group, 3-1,6-naphthyridinone group, 4-1,6-naphthyridinone group, 5-1,6-naphthyridinone group, 7-1,6-naphthyridinone group, 8-1,6-naphthyridinone group, 2-1,5-naphthyridines group, 3-1,5-naphthyridines group, 4-1,5-naphthyridines group, 6-1,5-naphthyridines group, 7-1,5-naphthyridines group, 8-1,5-naphthyridines group, 2-khinoksalinona group 5-khinoksalinona group, 6-khinoksalinona group, 2-chinazolinei group, 4-chinazolinei group, 5-chinazolinei group, 6-chinazolinei group, 7-chinazolinei group, 8-chinazolinei group, 3-indolinyl group, 4-indolinyl group, 5-indolinyl group, 6-indolinyl group, 7-indolinyl group, 8-indolinyl group, 2-parrinello group, 4-parrinello group, 6-parrinello group, 7-parrinello group, etc.

Substituted C2-14 aryl group may be a condensed bicyclic or tricyclic group, which is formed by condensation of the above C2-14aryl group with C2-9heterocyclic group, nitrogen-containing C2-9heterocyclic group or substituted C2-9heterocyclic group, and, in particular, can represent:

C2-14alloctype can be a C6-14alloctype that do not contain heteroatoms as atoms constituting the ring, or the aromatic C2-9geterotsiklicheskikh, and aromatic C2-9geterotsiklicheskikh can be a 5-7-membered monocyclic C2-6geterotsiklicheskikh, or 8-10-membered condensed bicyclic C5-9geterotsiklicheskikh, containing 1-3 oxygen atom, nitrogen atom or sulfur atom, alone or in combination.

C6-14alloctype, not containing heteroatoms, may constitute fenoxaprop, 1-ingenjorsfirma, 2-ingenjorsfirma, 3-ingenjorsfirma, 4-ingenjorsfirma, 5-ingenjorsfirma, 6-ingenjorsfirma, 7 ingenjorsfirma, α-naphthyloxy, β-naphthyloxy, 1-tetrahydronaphthalene, 2-tetrahydronaphthalene, 5-tetrahydronaphthalene, 6-tetrahydronaphthyl is oxygraph, on-biphenyloxy, m-biphenyloxy, p-biphenyloxy, 1-antioxycaps, 2-antioxycaps, 9-antioxycaps, 1-frontreleaseswrap, 2-frontreleaseswrap, 3-frontreleaseswrap, 4-frontreleaseswrap, 9-frontreleaseswrap etc.

5-7-membered monocyclic C2-6geterotsiklicheskikh can be a 2-taylortype, 3-taylortype, 2-ferrochrome, 3-ferrochrome, 2-pyranyloxy, 3-pyranyloxy, 4-pyranyloxy, 1-errollaceaply, 2-errollaceaply, 3-errollaceaply, 1-imidazolylalkyl, 2-imidazolinium, 4-imidazolylalkyl, 1-pyrazolylborate, 3-pyrazolinone, 4-pyrazolylborate, 2-thiazoleacetate, 4-thiazoleacetate, 5-thiazoleacetate, 3-isothiazolones, 4-isothiazolone, 5-isothiazolone, 2-oxazolidones, 4-oxazolidones, 5-oxazolinone, 3-isoxazolone, 4-isoxazolone, 5-isoxazolone, 2-pyridyloxy, 3-pyridyloxy, 4-pyridyloxy, 2-personalantispy, 2-pyrimidinamine, 4-pyrimidinamine, 5-pyrimidinamine, 3-pyridazinone, 4-pyridinylamino, 2-1,3,4-oxadiazoline, 2-1,3,4-thiadiazolidine, 3-1,2,4-oxadiazolyl, 5-1,2,4-oxadiazolyl, 3-1,2,4-tadias is laloxirape, 5-1,2,4-thiadiazolidine, 3-1,2,5-oxadiazolyl, 3-1,2,5-thiadiazolidine etc.

8-10-membered condensed bicyclic C5-9geterotsiklicheskikh can be a 2-benzoperoxide, 3-benzoperoxide, 4-benzoperoxide, 5-benzoperoxide, 6-benzoperoxide, 7 benzoperoxide, 1-isobenzofuranone, 4-isobenzofurandione, 5-isobenzofurandione, 2-benzothiadiazine, 3-benzothiadiazin, 4-benzothiadiazine, 5-benzothiadiazine, 6-benzothiadiazine, 7 benzothiadiazine, 1-isobenzofuranyl, 4-isobenzofurandione, 5-isobenzofuranyl, 2-promediacorp, 3-promediacorp, 4-promediacorp, 5-promediacorp, 6-promediacorp, 7 promediacorp, 8 promediacorp, 1-indolizinium, 2-indolizinium, 3-indolizinium, 5-indolizinium, 6-indolizinium, 7 indolizinium, 8-indolizinium, 1-isoindoline, 2-isoindoline, 4-isoindoline, 5-isoindoline, 1-indoleacetate, 2-indoleacetate, 3-indoleacetate, 4-indoleacetate, 5-indoleacetate, 6-indoleacetate, 7 indoleacetate, 1-indazolinone, 2-indazolinone, 3-indazolinone the group, 4-indazolinone, 5-indazolinone, 6-indazolinone, 7 indazolinone, 1-purinacare, 2-purinacare, 3-purinacare, 6-purinacare, 7 purinacare, 8-purinacare, 2-henrylacevedo, 3-henrylacevedo, 4-henrylacevedo, 5-henrylacevedo, 6-henrylacevedo, 7 henrylacevedo, 8-henrylacevedo, 1-ethenolysis, 3-ethenolysis, 4-ethenolysis, 5-ethenolysis, 6-ethenolysis, 7 ethenolysis, 8-ethenolysis, 1-phthalazinone, 5-phthalazinone, 6-phthalazinone, 1-2,7-naphthyridinone, 3-2,7-naphthyridinone, 4-2,7-naphthyridinone, 1-2,6-naphthyridinone, 3-2,6-naphthyridinone, 4-2,6-naphthyridinone, 2-1,8-naphthyridinone, 3-1,8-naphthyridinone, 4-1,8-naphthyridinone, 2-1,7-naphthyridinone, 3-1,7-naphthyridinone, 4-1,7-naphthyridinone, 5-1,7-naphthyridinone, 6-1,7-naphthyridinone, 8-1,7-naphthyridinone, 2-1,6-naphthyridinone, 3-1,6-naphthyridinone, 4-1,6-naphthyridinone, 5-1,6-naphthyridinone, 7-1,6-naphthyridinone, 8-1,6-naphthyridinone, 2-1,5-naphthyridinone, 3-1,5-naphthyridinone, 4-1,5-naphthyridinone, 6-1,5-naphthyridinone 7-1,5-naphthyridinone, 8-1,5-naphthyridinone, 2-hinoksalinovym, 5-hinoksalinovym, 6-hinoksalinovym, 2-ginasolinspu, 4-ginasolinspu, 5-ginasolinspu, 6-ginasolinspu, 7 ginasolinspu, 8-ginasolinspu, 3-linolenicacid, 4-linolenicacid, 5-linolenicacid, 6-linolenicacid, 7 linolenicacid, 8-linolenicacid, 2-partisianship, 4-partisianship, 6-partisianship, 7 partisianship etc.

C1-6acylcarnitine group can be linear or branched C3-6cycloalkylcarbonyl group and may represent methylcarbamyl, ethylcarbazole, n-propylboronic, isopropylcarbonate, cyclopropanecarbonyl, n-butylcarbamoyl, isobutylketone, second-butylcarbamoyl, tert-butylcarbamoyl, cyclobutanecarbonyl, 1-methyl-cyclopropanecarbonyl, 2-methylcyclopentanone, n-internabonal, 1-methyl-n-butylcarbamoyl, 2-methyl-n-butylcarbamoyl, 3-methyl-n-butylcarbamoyl, 1,1-dimethyl-n-propylboronic, 1,2-dimethyl-n-propylboronic, 2,2-dimethyl-n-propylboronic, 1-ethyl-n-propylboronic, cyclopentanecarbonyl, 1-methylcyclobutene, 2-methylcyclopentanone, 3-methylcyclopentadienyl, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropanecarboxylic, 1-ethylcyclopropane, 2-ethylcyclopentadienyl,n-hexylcaine, 1-methyl-n-internabonal, 2-methyl-n-internabonal, 3-methyl-n-internabonal, 4-methyl-n-internabonal, 1,1-dimethyl-n-butylcarbamoyl, 1,2-dimethyl-n-butylcarbamoyl, 1,3-dimethyl-n-butylcarbamoyl, 2,2-dimethyl-n-butylcarbamoyl, 2,3-dimethyl-n-butylcarbamoyl, 3,3-dimethyl-n-butylcarbamoyl, 1-ethyl-n-butylcarbamoyl, 2-ethyl-n-butylcarbamoyl, 1,1,2-trimethyl-n-propylboronic, 1,2,2-trimethyl-n-propylboronic, 1-ethyl-1-methyl-n-propylboronic, 1-ethyl-2-methyl-n-propylboronic, cyclo-hexylcaine, 1-methylcyclopentanol, 2-methylcyclopentadienyl, 3-methylcyclopentanol, 1-ethylcyclopropane, 2-ethylcyclopentadienyl, 3-ethylcyclopentadienyl, 1,2-dimethylcyclo-butylcarbamoyl, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutane, 2,3-dimethylcyclobutyl, 2,4-dimethylcyclobutane, 3,3-dimethylcyclobutyl, 1-n-propylcyclohexanone, 2-n-propylcyclohexanone, 1-ISO-propylcyclohexanone, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopentanone, 2-ethyl-1-methylcyclopentanol, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopropane etc.

C1-10acylcarnitine group can be linear or branched C3-10cycloalkylcarbonyl group, add what LNO to the above-mentioned groups, can be a 1-methyl-1-ethyl-n-internabonal, 1-heptylammonium, 2-heptylammonium, 1-ethyl-1,2-dimethyl-n-propylboronic, 1-ethyl-2,2-dimethyl-n-propylboronic, 1-octigabay, 3-octigabay, 4-methyl-3-n-heptylammonium, 6-methyl-2-n-heptylammonium, 2-propyl-1-n-heptylammonium, 2,4,4-trimethyl-1-n-internabonal, 1-noninterbank, 2-noninterbank, 2,6-dimethyl-4-n-heptylammonium, 3-ethyl-2,2-dimethyl-3-n-internabonal, 3,5,5-trimethyl-1-n-hexylcaine, 1-deceleron, 2-deceleron, 4-deceleron, 3,7-dimethyl-1-n-octigabay, 3,7-dimethyl-3-n-octigabay etc.

C1-10Tolkalina group can be linear or branched C3-10cyclotouring group and may represent a methylthio, ethylthio, n-propylthio, isopropylthio, cyclopropyl, n-butylthio, isobutyric, sec-butylthio, tert-butylthio, cyclobutyl, 1 methylcyclopropyl, 2-methylcyclopropyl, n-pentylthio, 1-methyl-n-butylthio, 2-methyl-n-butylthio, 3-methyl-n-butylthio, 1,1-dimethyl-n-propylthio, 1,2-dimethyl-n-propylthio, 2,2-dimethyl-n-propylthio, 1-ethyl-n-propylthio, cyclopentyl, 1 methylcyclobutene, 2-methylcyclobutane, 3 methylcyclobutene, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1 ethylcyclopropane, 2-ethylcyclopropane, n-hexylthio, 1-methyl-n-pentylthio, 2-methyl-n-pentylthio, 3-methyl-n-pentylthio, 4-methyl-n-pentylthio, 1,1-dimethyl-n-butylthio, 1,2-d is methyl-n-butylthio, 1,3-dimethyl-n-butylthio, 2,2-dimethyl-n-butylthio, 2,3-dimethyl-n-butylthio, 3,3-dimethyl-n-butylthio, 1-ethyl-n-butylthio, 2-ethyl-n-butylthio, 1,1,2-trimethyl-n-propylthio, 1,2,2-trimethyl-n-propylthio, 1-ethyl-1-methyl-n-propylthio, 1-ethyl-2-methyl-n-propylthio, cyclohexylthio, 1 Methylcyclopentane, 2-methylcyclopentene, 3-methylcyclopentene, 1 ethylcyclopentane, 2-ethylcyclopentane, 3 ethylcyclopentane, 1,2-dimethylcyclobutane, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutyl, 2,3-dimethylcyclobutyl, 2,4-dimethylcyclobutane, 3,3-dimethylcyclobutyl, 1-n-propyltrichlorosilane, 2-n-propyltrichlorosilane, 1 isopropylcarbamate, 2-isopropylcyclopentadienyl, 1,2,2-trimethylpropyl, 1,2,3-trimethylolpropane, 2,2,3-trimethylpropyl, 1-ethyl-2-methylcyclopropyl, 2-ethyl-1-methylcyclopropyl, 2-ethyl-2-methylcyclopropyl, 2-ethyl-3-methylcyclopropyl, 1-methyl-1-ethyl-n-pentylthio, 1 Reptilia, 2-reptilio, 1-ethyl-1,2-dimethyl-n-propylthio, 1-ethyl-2,2-dimethyl-n-propylthio, 1 octylthio, 3 octylthio, 4-methyl-3-n-Reptilia, 6-methyl-2-n-Reptilia, 2-propyl-1-n-Reptilia, 2,4,4-trimethyl-1-n-pentylthio, 1 nonillion, 2-nonillion, 2,6-dimethyl-4-n-Reptilia, 3-ethyl-2,2-dimethyl-3-n-pentylthio, 3,5,5-trimethyl-1-n-hexylthio, 1-decillia, 2-decillia, 4-decillia, 3,7-dimethyl-1-n-octylthio, 3,7-dimethyl-3-n-octylthio etc.

C1-6alkylsulfonamides can be linear, branched what if C 3-6cycloalkylcarbonyl and can represent methylsulfonylamino, ethylsulfonyl, n-propylsulfonyl, out-propylsulfonyl, cyclo-propylsulfonyl, n-butylsulfonyl, out-butylsulfonyl, sec-butylsulfonyl, tert-butylsulfonyl, cyclo-butylsulfonyl, 1 methylcyclopentadiene, 2-methylcyclopentadiene, n-pentylaniline, 1-methyl-n-butylsulfonyl, 2-methyl-n-butylmethylamine, 3-methyl-n-butylmethylamine, 1,1-dimethyl-n-propylsulfonyl, 1,2-dimethyl-n-propylsulfonyl, 2,2-dimethyl-n-propylsulfonyl, 1-ethyl-n-propylsulfonyl, cyclopentylamine, 1 methylcyclohexylamine, 2-methylcyclohexylamine, 3 Methylchloroisothiazolinone, 1,2-dimethylcyclopropanecarboxylate, 2,3-dimethylcyclopropanecarboxylate, 1 ethylcyclohexylamine, 2-ethylcyclohexylamine, n-hexylaniline, 1-methyl-n-pentylaniline, 2-methyl-n-pentylaniline, 3-methyl-n-pentylaniline, 4-methyl-n-pentylaniline, 1,1-dimethyl-n-butylmethylamine, 1,2-dimethyl-n-butylmethylamine, 1,3-dimethyl-n-butylmethylamine, 2,2-dimethyl-n-butylmethylamine, 2,3-dimethyl-n-butylmethylamine, 3,3-dimethyl-n-butylsulfonyl, 1-ethyl-n-butylsulfonyl, 2-ethyl-n-BU is resultonline, 1,1,2-trimethyl-n-propylsulfonyl, 1,2,2-trimethyl-n-propylsulfonyl, 1-ethyl-1-methyl-n-propylsulfonyl, 1-ethyl-2-methyl-n-propylsulfonyl, cyclo-hexylaniline, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 methylcyclopentadienyl, 1 ethylcyclohexylamine, 2-ethylcyclohexylamine, 3 ethylcyclohexylamine, 1,2-dimethylcyclohexylamine, 1,3-dimethylcyclohexylamine, 2,2-dimethylcyclohexylamine, 2,3-dimethylcyclohexylamine, 2,4-dimethylcyclohexylamine, 3,3-dimethylcyclohexylamine, 1-n-propylcyclohexanone, 2-n-propyltrichlorosilane, 1 isopropylcyclopentadienyl, 2-isopropylcyclopentadienyl, 1,2,2-trimethylsilylmethylamine, 1,2,3-trimethylsilylmethylamine, 2,2,3-trimethylsilylmethylamine, 1-ethyl-2-methylcyclopentadiene, 2-ethyl-1-methylcyclopentadiene, 2-ethyl-2-methylcyclopentadiene, 2-ethyl-3-methylcyclopentadiene etc.

C1-10alkylsulfonamides may be linear or branched C3-10cycloalkylcarbonyl and, in addition to the above-mentioned groups may be a 1-methyl-1-ethyl-n-pentylaniline, 1 heptylaniline, 2-hept is sulfonylamino, 1-ethyl-1,2-dimethyl-n-propylsulfonyl, 1-ethyl-2,2-dimethyl-n-propylsulfonyl, 1 octylaniline, 3 octylaniline, 4-methyl-3-n-heptylaniline, 6-methyl-2-n-heptylaniline, 2-propyl-1-n-heptylaniline, 2,4,4-trimethyl-1-n-pentylaniline, 1 nonsulfonylurea, 2-nonsulfonylurea, 2,6-dimethyl-4-n-heptylaniline, 3-ethyl-2,2-dimethyl-3-n-pentylaniline, 3,5,5-trimethyl-1-n-hexylaniline, 1 decellularisation, 2-decellularisation, 4-decellularisation, 3,7-dimethyl-1-n-octylaniline, 3,7-dimethyl-3-n-octylaniline, cycloheptylamine, cyclo-octylaniline, 1 methylcyclohexylamine, 2-methylcyclohexylamine, 3 methylcyclohexylamine, 1,2-dimethylcyclohexylamine, 1 ethylcyclohexylamine, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 methylcyclopentadienyl etc.

C1-6alkoxygroup may be linear or branched C3-10cycloalexie and may represent a methoxy, ethoxy, n-propoxy, isopropoxy, cyclopropane, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, CYCLOBUTANE, 1 methylcyclopropane, 2-methylcyclopropane, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,dimethyl-n-propoxy, 1-ethyl-n-propoxy, cyclopentyloxy, 1 methylcyclobutane, 2-methylcyclobutane, 3 methylcyclobutane, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1 ethylcyclopropane, 2-ethylcyclopropane, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, cyclohexyloxy, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 Methylcyclopentane, 1 ethylcyclohexyl, 2-ethylcyclohexyl, 3 ethylcyclohexyl, 1,2-dimethylcyclobutane, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutane, 2,3-dimethylcyclohexyl, 2,4-dimethylcyclobutane, 3,3-dimethylcyclobutane, 1-n-propylcyclohexyl, 2-n-propylcyclohexyl, 1 isopropylcarbamate, 2-isopropylcarbamate, 1,2,2-trimethylolpropane, 1,2,3-trimethylolpropane, 2,2,3-trimethylolpropane, 1-ethyl-2-methylcyclopropane, 2-ethyl-1-methylcyclopropane, 2-ethyl-2-methylcyclopropane, 2-ethyl-3-methylcyclopropane etc.

C1-10alkoxygroup may be linear or branched C3-10cycloalexie and may represent a methoxy, ethoxy, n-propoxy, isopropoxy, cycloprop the XI, n-butoxy, isobutoxy, sec-butoxy, tert-butoxy, CYCLOBUTANE, 1 methylcyclopropane, 2-methylcyclopropane, n-pentyloxy, 1-methyl-n-butoxy, 2-methyl-n-butoxy, 3-methyl-n-butoxy, 1,1-dimethyl-n-propoxy, 1,2-dimethyl-n-propoxy, 2,2-dimethyl-n-propoxy, 1-ethyl-n-propoxy, cyclopentyloxy, 1 methylcyclobutane, 2-methylcyclobutane, 3 methylcyclobutane, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1 ethylcyclopropane, 2-ethylcyclopropane, n-hexyloxy, 1-methyl-n-pentyloxy, 2-methyl-n-pentyloxy, 3-methyl-n-pentyloxy, 4-methyl-n-pentyloxy, 1,1-dimethyl-n-butoxy, 1,2-dimethyl-n-butoxy, 1,3-dimethyl-n-butoxy, 2,2-dimethyl-n-butoxy, 2,3-dimethyl-n-butoxy, 3,3-dimethyl-n-butoxy, 1-ethyl-n-butoxy, 2-ethyl-n-butoxy, 1,1,2-trimethyl-n-propoxy, 1,2,2-trimethyl-n-propoxy, 1-ethyl-1-methyl-n-propoxy, 1-ethyl-2-methyl-n-propoxy, cyclohexyloxy, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 Methylcyclopentane, 1 ethylcyclohexyl, 2-ethylcyclohexyl, 3 ethylcyclohexyl, 1,2-dimethylcyclobutane, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutane, 2,3-dimethylcyclohexyl, 2,4-dimethylcyclobutane, 3,3-dimethylcyclobutane, 1-n-propylcyclohexyl, 2-n-propylcyclohexyl, 1 isopropylcarbamate, 2-isopropylcarbamate, 1,2,2-trimethylolpropane, 1,2,3-trimethylolpropane, 2,2,3-trimethylolpropane, 1-ethyl-2-methylcyclopropane, 2-ethyl-1-methylcyclopropane,2-ethyl-2-methylcyclopropane, 2-ethyl-3-methylcyclopropene, 1-methyl-1-ethyl-n-pentyloxy, 1-heptyloxy, 2-heptyloxy, 1-ethyl-1,2-dimethyl-n-propyloxy, 1-ethyl-2,2-dimethyl-n-propyloxy, 1-octyloxy, 3-octyloxy, 4-methyl-3-n-heptyloxy, 6-methyl-2-n-heptyloxy, 2-propyl-1-n-heptyloxy, 2,4,4-trimethyl-1-n-pentyloxy, 1 nonyloxy, 2-nonyloxy, 2,6-dimethyl-4-n-heptyloxy, 3-ethyl-2,2-dimethyl-3-n-pentyloxy, 3,5,5-trimethyl-1-n-hexyloxy, 1 decyloxy, 2-decyloxy, 4-decyloxy, 3,7-dimethyl-1-n-octyloxy, 3,7-dimethyl-3-n-octyloxy and the like

C1-6alkyldiethanolamine group represents a C1-6alkylcarboxylic group that instead of the oxygen atom is a sulfur atom, it may be linear or branched C3-6cycloalkylcarbonyl group can be a methyl(thiocarbonyl), ethyl(thiocarbonyl), n-propyl(thiocarbonyl), isopropyl(thiocarbonyl), cyclopropyl(thiocarbonyl), n-butyl(thiocarbonyl), isobutyl(thiocarbonyl), sec-butyl(thiocarbonyl), tert-butyl(thiocarbonyl), cyclobutyl(thiocarbonyl), 1-methylcyclopropyl(thiocarbonyl), 2-methylcyclopropyl(thiocarbonyl), n-pentyl(thiocarbonyl), 1-methyl-n-butyl(thiocarbonyl), 2-methyl-n-butyl(thiocarbonyl), 3-methyl-n-butyl(thiocarbonyl), 1,1-dimethyl-n-propyl(thiocarbonyl), 1,2-dimethyl-n-propyl(thiocarbonyl), 2,2-dimethyl-n-propyl(thiocarbonyl), 1-ethyl-n-propyl(thiocarbonyl), cyclopentyl(thiocarbonyl), 1-methylcyclobutene(thiocarbonyl), 2-METI cyclobutyl(thiocarbonyl), 3-methylcyclobutene(thiocarbonyl), 1,2-dimethylcyclopropene(thiocarbonyl), 2,3-dimethylcyclopropane(thiocarbonyl), 1-ethylcyclopropane(thiocarbonyl), 2-ethylcyclopropane(thiocarbonyl), n-hexyl(thiocarbonyl), 1-methyl-n-pentyl(thiocarbonyl), 2-methyl-n-pentyl(thiocarbonyl), 3-methyl-n-pentyl(thiocarbonyl), 4-methyl-n-pentyl(thiocarbonyl), 1,1-dimethyl-n-butyl(thiocarbonyl), 1,2-dimethyl-n-butyl(thiocarbonyl), 1,3-dimethyl-n-butyl(thiocarbonyl), 2,2-dimethyl-n-butyl(thiocarbonyl), 2,3-dimethyl-n-butyl(thiocarbonyl), 3,3-dimethyl-n-butyl(thiocarbonyl), 1-ethyl-n-butyl(thiocarbonyl), 2-ethyl-n-butyl(thiocarbonyl), 1,1,2-trimethyl-n-propyl(thiocarbonyl), 1,2,2-trimethyl-n-propyl(thiocarbonyl), 1-ethyl-1-methyl-n-propyl(thiocarbonyl), 1-ethyl-2-methyl-n-propyl(thiocarbonyl), cyclohexyl(thiocarbonyl), 1-methylcyclopentene(thiocarbonyl), 2-methylcyclopentanol(thiocarbonyl), 3-methylcyclopentene(thiocarbonyl), 1-ethylcyclohexyl(thiocarbonyl), 2-ethylcyclohexyl(thiocarbonyl), 3-ethylcyclohexyl(thiocarbonyl), 1,2-dimethylcyclobutyl(thiocarbonyl), 1,3-dimethylcyclobutyl(thiocarbonyl), 2,2-dimethylcyclobutyl(thiocarbonyl), 2,3-dimethylcyclobutyl(thiocarbonyl), 2,4-dimethylcyclobutyl(thiocarbonyl), 3,3-dimethylcyclobutyl(thiocarbonyl), 1-n-propylcyclohexyl(thiocarbonyl), 2-n-propylcyclohexyl(thiocarbonyl), 1-isopropylcyclohexane(thiocarbonyl), 2-isopropylcyclohexane(thiocarbonyl), 1,2,2-trimethylpropyl(thiocarbonyl), 1,2,3-trim telekabel(thiocarbonyl), 2,2,3-trimethylpropyl(thiocarbonyl), 1-ethyl-2-methylcyclopropyl(thiocarbonyl), 2-ethyl-1-methylcyclopropyl(thiocarbonyl), 2-ethyl-2-methylcyclopropyl(thiocarbonyl), 2-ethyl-3-methylcyclopropyl(thiocarbonyl), etc.

C1-10alkyldiethanolamine group can be linear or branched C3-10cycloalkylcarbonyl group and, in addition to the above groups can be a 1-methyl-1-ethyl-n-pentyl(thiocarbonyl), 1-heptyl(thiocarbonyl), 2-heptyl(thiocarbonyl), 1-ethyl-1,2-dimethyl-n-propyl(thiocarbonyl), 1-ethyl-2,2-dimethyl-n-propyl(thiocarbonyl), 1-octyl(thiocarbonyl), 3-octyl(thiocarbonyl), 4-methyl-3-n-heptyl(thiocarbonyl), 6-methyl-2-n-heptyl(thiocarbonyl), 2-propyl-1-n-heptyl(thiocarbonyl), 2,4,4-trimethyl-1-n-pentyl(thiocarbonyl), 1 Neil(thiocarbonyl), 2-nonyl(thiocarbonyl), 2,6-dimethyl-4-n-heptyl(thiocarbonyl), 3-ethyl-2,2-dimethyl-3-n-pentyl(thiocarbonyl), 3,5,5-trimethyl-1-n-hexyl(thiocarbonyl), 1-decyl(thiocarbonyl), 2-decyl(thiocarbonyl), 4-decyl(thiocarbonyl), 3,7-dimethyl-1-n-octyl(thiocarbonyl), 3,7-dimethyl-3-n-octyl(thiocarbonyl), etc.

C1-6alkylsulfonyl group can be linear or branched C3-6cycloalkylcarbonyl group and can be a methylsulphonyl, ethylsulfonyl, n-propylsulfonyl, isopropylphenyl, cyclopropanesulfonyl, n-butylsulfonyl, isobutylphenyl, second-butylsulfonyl,tert-butylsulfonyl, cyclobutylmethyl, 1-methylcyclopropyl, 2-methylcyclopropyl, n-peterculter, 1-methyl-n-butylsulfonyl, 2-methyl-n-butylsulfonyl, 3-methyl-n-butylsulfonyl, 1,1-dimethyl-n-propylsulfonyl, 1,2-dimethyl-n-propylsulfonyl, 2,2-dimethyl-n-propylsulfonyl, 1-ethyl-n-propylsulfonyl, cyclopentylmethyl, 1-methylcyclobutane, 2-methylcyclopentanone, 3-methylcyclopentadienyl, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1-ethylcyclopropane, 2-ethylcyclopentadienyl, n-hexylsilane, 1-methyl-n-peterculter, 2-methyl-n-peterculter, 3-methyl-n-peterculter, 4-methyl-n-peterculter, 1,1-dimethyl-n-butylsulfonyl, 1,2-dimethyl-n-butylsulfonyl, 1,3-dimethyl-n-butylsulfonyl, 2,2-dimethyl-n-butylsulfonyl, 2,3-dimethyl-n-butylsulfonyl, 3,3-dimethyl-n-butylsulfonyl, 1-ethyl-n-butylsulfonyl, 2-ethyl-n-butylsulfonyl, 1,1,2-trimethyl-n-propylsulfonyl, 1,2,2-trimethyl-n-propylsulfonyl, 1-ethyl-1-methyl-n-propylsulfonyl, 1-ethyl-2-methyl-n-propylsulfonyl, cyclohexylcarbonyl, 1-methylcyclopentanol, 2-methylcyclopentanone, 3-methylcyclopentanol, 1-ethylcyclopentadienyl, 2-ethylcyclopentadienyl, 3-ethylcyclopentadienyl, 1,2-dimethylcyclobutane, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutane, 2,3-dimethylcyclobutyl, 2,-dimethylcyclobutane, 3,3-dimethylcyclobutyl, 1-n-propylcyclohexanone, 2-n-propylcyclohexanone, 1-isopropylcyclopentadienyl, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopentanone, 2-ethyl-1-methylcyclopropyl, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopropane etc.

C1-10alkylsulfonyl group can be linear or branched C3-10cycloalkylcarbonyl group and, in addition to the above-mentioned groups may be a 1-methyl-1-ethyl-n-peterculter, 1-heptylaniline, 2-heptylaniline, 1-ethyl-1,2-dimethyl-n-propylsulfonyl, 1-ethyl-2,2-dimethyl-n-propylsulfonyl, 1-octylsilane, 3-octylsilane, 4-methyl-3-n-heptylaniline, 6-methyl-2-n-heptylaniline, 2-propyl-1-n-heptylaniline, 2,4,4-trimethyl-1-n-peterculter, 1-nonalcoholic, 2-nonalcoholic, 2,6-dimethyl-4-n-heptylaniline, 3-ethyl-2,2-dimethyl-3-n-peterculter, 3,5,5-trimethyl-1-n-hexylsilane, 1-decimalpoint, 2-decimalpoint, 4-decimalpoint, 3,7-dimethyl-1-n-octylsilane, 3,7-dimethyl-3-n-octylsilane, cycloheptylmethyl, cyclooctylmethyl, 1-methylcyclohexylamine, 2-methylcyclohexylamine, 3-methylcyclohexylamine, 1,2-dimethylcyclohexylamine is, 1-ethylcyclohexylamine, 1-methylcyclopentanol, 2-methylcyclopentanone, 3-methylcyclopentadienyl etc.

C1-6alkoxycarbonyl group can be linear or branched C3-6cycloalkylcarbonyl group and may represent methoxycarbonyl, etoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl, cyclopropanecarbonyl, n-butoxycarbonyl, isobutoxide, second-butoxycarbonyl, tert-butoxycarbonyl, cyclobutanecarbonyl, 1-methylcyclopentanol, 2-methylcyclohexylamine, n-pentyloxybenzoyl, 1-methyl-n-butoxycarbonyl, 2-methyl-n-butoxycarbonyl, 3-methyl-n-butoxycarbonyl, 1,1-dimethyl-n-propoxycarbonyl, 1,2-dimethyl-n-propoxycarbonyl, 2,2-dimethyl-n-propoxycarbonyl, 1-ethyl-n-propoxycarbonyl, cyclopentanecarbonyl, 1-methylcyclohexanol, 2-methylcyclohexanol, 3-methylcyclohexanol, 1,2-dimethylcyclopropanecarboxylic, 2,3-dimethylcyclopropanecarboxylic, 1-ethylcyclohexylamine, 2-ethylcyclohexylamine, n-hexyloxymethyl, 1-methyl-n-pentyloxybenzoyl, 2-methyl-n-pentyloxybenzoyl, 3-methyl-n-pentyloxybenzoyl, 4-methyl-n-pentyloxybenzoyl, 1,1-dimethyl-n-butoxycarbonyl, 1,2-dimethyl-n-butoxycarbonyl, 1,3-dimethyl-n-butoxycarbonyl, 2,2-dimethyl-n-butoxycarbonyl, 2,3-dimethyl-n-butoxycarbonyl, 3,3-dimethyl-n-butox is carbonyl, 1-ethyl-n-butoxycarbonyl, 2-ethyl-n-butoxycarbonyl, 1,1,2-trimethyl-n-propoxycarbonyl, 1,2,2-trimethyl-n-propoxycarbonyl, 1-ethyl-1-methyl-n-propoxycarbonyl, 1-ethyl-2-methyl-n-propoxycarbonyl, cyclohexyloxycarbonyl, 1-methylcyclopentadiene, 2-methylcyclopentadienyl, 3-methylcyclopentadienyl, 1-ethylcyclohexylamine, 2-ethylcyclohexylamine, 3-ethylcyclohexylamine, 1,2-dimethylcyclohexane, 1,3-dimethylcyclohexane, 2,2-dimethylcyclohexanone, 2,3-dimethylcyclohexylamine, 2,4-dimethylcyclohexylamine, 3,3-dimethylcyclohexane, 1-n-propylcyclohexanone, 2-n-propylcyclohexanone, 1-isopropylcyclopentadienyl, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclohexanol, 1-ethyl-2-methylcyclopentanone, 2-ethyl-1-methylcyclohexylamine, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopropane etc.

C1-10alkoxycarbonyl group can be linear or branched C3-10cycloalkylcarbonyl group and, in addition to the above-mentioned groups may be a 1-methyl-1-ethyl-n-pentyloxybenzoyl, 1-heptyloxybiphenyl, 2-heptyloxybiphenyl, 1-ethyl-1,2-dimethyl-n-propylenecarbonate, 1-ethyl-2,2-dime the Il-n-propylenecarbonate, 1-octyloxybiphenyl, 3-octyloxyphenyl, 4-methyl-3-n-heptyloxybiphenyl, 6-methyl-2-n-heptyloxybiphenyl, 2-propyl-1-n-heptyloxybiphenyl, 2,4,4-trimethyl-1-n-pentyloxybenzoyl, 1-nonlexically, 2-nonlexically, 2,6-dimethyl-4-n-heptyloxybenzoic, 3-ethyl-2,2-dimethyl-3-n-pentyloxybenzoyl, 3,5,5-trimethyl-1-n-hexyloxybenzoyl, 1-decyloxybenzoic, 2-decyloxybenzoic, 4-decyloxybenzoic, 3,7-dimethyl-1-n-octyloxybiphenyl, 3,7-dimethyl-3-n-octyloxybiphenyl, etc.

C1-10alkylcarboxylic may be linear or branched C3-10cycloalkylcarbonyl and can represent methylcarbonate, ethylcarbonate, n-propylmalonate, isopropylcarbonate, cyclopropanecarboxylate, n-BUTYLCARBAMATE, isobutyryloxy, sec-butylcarbamoyl, tert-BUTYLCARBAMATE, cyclobutanecarbonyl, 1 methylcyclopentanone, 2-methylcyclopentanone, n-intercorporate, 1-methyl-n-BUTYLCARBAMATE, 2-methyl-n-BUTYLCARBAMATE, 3-methyl-n-BUTYLCARBAMATE, 1,1-dimethyl-n-propylmalonate, 1,2-dimethyl-n-propylmalonate, 2,2-dimethyl-n-propylmalonate, 1-ethyl-n-propylmalonate cyclopentanecarboxylate, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 methylcyclobutane, 1,2-dimethylcyclopropanecarboxylate, 2,3-dimethylcyclopropane is carbonyloxy, 1 ethylcyclopropane, 2-ethylcyclopropane, n-hexylcaine, 1-methyl-n-intercorporate, 2-methyl-n-intercorporate, 3-methyl-n-intercorporate, 4-methyl-n-intercorporate, 1,1-dimethyl-n-BUTYLCARBAMATE, 1,2-dimethyl-n-BUTYLCARBAMATE, 1,3-dimethyl-n-BUTYLCARBAMATE, 2,2-dimethyl-n-BUTYLCARBAMATE, 2,3-dimethyl-n-BUTYLCARBAMATE, 3,3-dimethyl-n-BUTYLCARBAMATE, 1-ethyl-n-BUTYLCARBAMATE, 2-ethyl-n-BUTYLCARBAMATE, 1,1,2-trimethyl-n-propylmalonate, 1,2,2-trimethyl-n-propylmalonate, 1-ethyl-1-methyl-n-propylmalonate, 1-ethyl-2-methyl-n-propylmalonate, cyclohexylcarbonyl, 1 methylcyclopentanone, 2-methylcyclopentanone, 3 methylcyclopentanone, 1 ethylcyclopropane, 2-ethylcyclopropane, 3 ethylcyclopropane, 1,2-dimethylcyclobutane, 1,3-dimethylcyclopropanecarboxylate, 2,2-dimethylcyclopropanecarboxylate, 2,3-dimethylcyclopropanecarboxylate, 2,4-dimethylcyclopropanecarboxylate, 3,3-dimethylcyclopropanecarboxylate, 1-n-propylcyclohexanone, 2-n-propylcyclohexanone, 1 isopropylcyclopentadienyl, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopropane and, 2-ethyl-1-methylcyclopentanone, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopropene, 1-methyl-1-ethyl-n-intercorporate, 1 latikambourke, 2-heptylammonium, 1-ethyl-1,2-dimethyl-n-propylmalonate, 1-ethyl-2,2-dimethyl-n-propylmalonate, 1 octylcarbinol, 3 octylcarbinol, 4-methyl-3-n-heptylammonium, 6-methyl-2-n-heptylammonium, 2-propyl-1-n-heptylammonium, 2,4,4-trimethyl-1-n-intercorporate, 1 monicabellucci, 2-monicabellucci, 2,6-dimethyl-4-n-heptylammonium, 3-ethyl-2,2-dimethyl-3-n-intercorporate, 3,5,5-trimethyl-1-n-hexylcaine, 1 dellcorporate, 2-dellcorporate, 4-dellcorporate, 3,7-dimethyl-1-n-octylcarbinol, 3,7-dimethyl-3-n-octylcarbinol etc.

C1-10alkylcarboxylic may be linear or branched C3-10cycloalkylcarbonyl and can represent methylcobalamine, ethylcarbodiimide, n-propylnitrosamine, isopropylcarbodiimide, cyclopropanecarbonyl, n-BUTYLCARBAMATE, isobutylamino, sec-butylcarbamoyl, tert-butylcarbamoyl, cyclobutanecarbonyl, 1 methylcyclohexylamine, 2-methylcyclohexylamine, n-intelcorporation, 1-methyl-n-BUTYLCARBAMATE, 2-methyl-n-BUTYLCARBAMATE, 3-methyl-n-BUTYLCARBAMATE, 1,1-dimethyl-n-is replicability, 1,2-dimethyl-n-propylnitrosamine, 2,2-dimethyl-n-propylnitrosamine, 1-ethyl-n-propylnitrosamine, cyclopentanecarbonyl, 1 methylcyclohexylamine, 2-methylcyclohexylamine, 3 methylcyclohexylamine, 1,2-dimethylcyclopropanecarboxylate, 2,3-dimethylcyclopropanecarboxylate, 1 ethylcyclohexylamine, 2-ethylcyclohexylamine, n-paxilonline, 1-methyl-n-intelcorporation, 2-methyl-n-intelcorporation, 3-methyl-n-intelcorporation, 4-methyl-n-intelcorporation, 1,1-dimethyl-n-BUTYLCARBAMATE, 1,2-dimethyl-n-BUTYLCARBAMATE, 1,3-dimethyl-n-BUTYLCARBAMATE, 2,2-dimethyl-n-BUTYLCARBAMATE, 2,3-dimethyl-n-BUTYLCARBAMATE, 3,3-dimethyl-n-BUTYLCARBAMATE, 1-ethyl-n-BUTYLCARBAMATE, 2-ethyl-n-BUTYLCARBAMATE, 1,1,2-trimethyl-n-propylnitrosamine, 1,2,2-trimethyl-n-propylnitrosamine, 1-ethyl-1-methyl-n-propylnitrosamine, 1-ethyl-2-methyl-n-propylnitrosamine, cyclohexylcarbodiimide, 1 methylcyclopentadiene, 2 methylcyclopentadienyl, 3 methylcyclopentadiene, 1 ethylcyclohexylamine, 2-ethylcyclohexylamine, 3 ethylcyclohexylamine, 1,2-dimethylcyclohexylamine, 1,3-dimethylcyclohexylamine, 2,2-dimethylcyclopropanecarboxylate, 2,3-dimethylcyclohexylamine, 2,4-dimethylcyclohexylamine,3,3-dimethylcyclohexylamine, 1-n-propylcyclohexanone, 2-n-propylcyclohexanone, 1-ISO-propylcyclohexanone, 2-ISO-propylcyclohexanone, 1,2,2-trimethylcyclohexylamine, 1,2,3-trimethylcyclohexylamine, 2,2,3-trimethylcyclohexylamine, 1-ethyl-2-methylcyclohexylamine, 2-ethyl-1-methylcyclohexylamine, 2-ethyl-2-methylcyclohexylamine, 2-ethyl-3-methylcyclohexylamine, 1-methyl-1-ethyl-n-intelcorporation, 1 heptylammonium, 2-heptylcyclopentanone, 1-ethyl-1,2-dimethyl-n-propylnitrosamine, 1-ethyl-2,2-dimethyl-n-propylnitrosamine, 1 octylcarbinol, 3 octylcarbinol, 4-methyl-3-n-heptylammonium, 6-methyl-2-n-heptylcyclopentanone, 2-propyl-1-n-heptylammonium, 2,4,4-trimethyl-1-n-intelcorporation, 1 nonincorporation, 2-nonincorporation, 2,6-dimethyl-4-n-heptylammonium, 3-ethyl-2,2-dimethyl-3-n-intelcorporation, 3,5,5-trimethyl-1-n-paxilonline, 1 metilcarbonievy, 2-metilcarbonievy, 4-metilcarbonievy, 3,7-dimethyl-1-n-octylcarbinol, 3,7-dimethyl-3-n-octylcarbinol etc.

C1-10monoalkylamines may be linear or branched C3-10cycloalkylation and can be methylamino, ethylamino, n-propylamino, isopropylamino, cyclopropylamino, n-butylamino, isobutylamino, second-Buti is amino, tert-butylamino, cyclobutylamine, 1 methylcyclopropyl, 2-methylcyclopropyl, n-pentylamine, 1-methyl-n-butylamino, 2-methyl-n-butylamine, 3-methyl-n-butylamino, 1,1-dimethyl-n-Propylamine, 1,2-dimethyl-n-propylamino, 2,2-dimethyl-n-propylamino, 1-ethyl-n-propylamino, cyclopentylamine, 1 methylcyclohexylamine, 2-methylcyclohexylamine, 3 methylcyclobutene, 1,2-dimethylcyclopropane, 2,3-dimethylcyclopropane, 1 ethylcyclopropane, 2 ethylcyclopropane, n-hexylamine, 1-methyl-n-pentylamine, 2-methyl-n-pentylamine, 3-methyl-n-pentylamine, 4-methyl-n-pentylamine, 1,1-dimethyl-n-butylamine, 1,2-dimethyl-n-butylamino, 1,3-dimethyl-n-butylamino, 2,2-dimethyl-n-butylamino, 2,3-dimethyl-n-butylamino, 3,3-dimethyl-n-butylamino, 1-ethyl-n-butylamino, 2-ethyl-n-butylamino, 1,1,2-trimethyl-n-propylamino, 1,2,2-trimethyl-n-propylamino, 1-ethyl-1-methyl-n-propylamino, 1-ethyl-2-methyl-n-propylamino, cyclohexylamino, 1 methylcyclopentadiene, 2-methylcyclopentanone, 3 methylcyclopentadiene, 1 ethylcyclohexylamine, 2-ethylcyclohexylamine, 3 ethylcyclohexylamine, 1,2-dimethylcyclobutane, 1,3-dimethylcyclobutane, 2,2-dimethylcyclobutane, 2,3-dimethylcyclohexylamine, 2,4-dimethylcyclobutane, 3,3-dimethylcyclobutyl, 1-n-propyltrichlorosilane, 2-n-propyltrichlorosilane, 1-ISO-propylcyclohexanone, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclohex is pilipino, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopropyl, 2-ethyl-1-methylcyclopropyl, 2-ethyl-2-methylcyclopropyl, 2-ethyl-3-methylcyclopropyl, 1-methyl-1-ethyl-n-pentylamine, 1 heptylamine, 2-heptylamine, 1-ethyl-1,2-dimethyl-n-propylamino, 1-ethyl-2,2-dimethyl-n-propylamino, 1 octylamine, 3 octylamine, 4-methyl-3-n-heptylamine, 6-methyl-2-n-heptylamine, 2-propyl-1-n-heptylamine, 2,4,4-trimethyl-1-n-pentylamine, 1 nonylamine, 2-nonylamine, 2,6-dimethyl-4-n-heptylamine, 3-ethyl-2,2-dimethyl-3-n-pentylamine, 3,5,5-trimethyl-1-n-hexylamino, 1 decylamine, 2-decylamine, 4-decylamine, 3,7-dimethyl-1-n-octylamine, 3,7-dimethyl-3-n-octylamine etc.

C1-10dialkylamino can be symmetric or asymmetric. Symmetric C1-10dialkylamino may be linear or branched C3-10cycloalkylation and can represent and dimethylamino, diethylamino, di-n-propylamino, diisopropylamino, Dicyclopentadiene, di-n-butylamino, diisobutylamine, di-sec-butylamino, di-tert-butylamino, Dicyclopentadiene, di-(1-methyl-cyclopropyl)amino, di-(2-methylcyclopropyl)amino, di-n-pentylamine, di-(1-methyl-n-butyl)amino, di-(2-methyl-n-butyl)amino, di-(3-methyl-n-butyl)amino, di-(1,1-dimethyl-n-propyl)amino, di-(1,2-dimethyl-n-propyl)amino, di-(2,2-dimethyl-n-propyl)amino, di-(1-ethyl-n-propyl)amino, dicyclopenta is laminitis, di-(1-methylcyclobutene)amino, di-(2-methylcyclohexyl)amino, di-(3-methylcyclobutene)amino, di-(1,2-dimethylcyclopropene)amino, di-(2,3-dimethylcyclopropane)amino, di-(1-ethylcyclopropane)amino, di-(2-ethylcyclopropane)amino, di-n-hexylamino, di-(1-methyl-n-pentyl)amino, di-(2-methyl-n-pentyl)amino, di-(3-methyl-n-pentyl)amino, di-(4-methyl-n-pentyl)amino, di-(1,1-dimethyl-n-butyl)amino, di-(1,2-dimethyl-n-butyl)amino, di-(1,3-dimethyl-n-butyl)amino, di-(2,2-dimethyl-n-butyl)amino, di-(2,3-dimethyl-n-butyl)amino, di-(3,3-dimethyl-n-butyl)amino, di-(1-ethyl-n-butyl)amino, di-(2-ethyl-n-butyl)amino, di-(1,1,2-trimethyl-n-propyl)amino, di-(1,2,2-trimethyl-n-propyl)amino, di-(1-ethyl-1-methyl-n-propyl)amino, di-(1-ethyl-2-methyl-n-propyl)amino, dicyclohexylamine, di-(1-methylcyclopentene)amino, di-(2-methylcyclopentene)amino, di-(3-methylcyclopentene)amino, di-(1-ethylcyclohexyl)amino, di-(2-ethylcyclohexyl)amino, di-(3-ethylcyclohexyl)amino, di-(1,2-dimethylcyclobutyl)amino, di-(1,3-dimethylcyclobutyl)amino, di-(2,2-dimethylcyclobutyl)amino, di-(2,3-dimethylcyclobutyl)amino, di-(2,4-dimethylcyclobutyl)amino, di-(3,3-dimethylcyclobutyl)amino, di-(1-n-propylcyclohexyl)amino, di-(2-n-propylcyclohexyl)amino, di-(1-isopropylcyclohexane)amino, di-(2-isopropylcyclohexane)amino, di-(1,2,2-trimethylpropyl)amino, di-(1,2,3-trimethylpropyl)amino, di-(2,2,3-trimethylpropyl)amino, di-(1-ethyl-2-methylcyclopropyl)amino, di-(2-the Teal-1-methylcyclopropyl)amino, di-(2-ethyl-2-methylcyclopropyl)amino, di-(2-ethyl-3-methylcyclopropyl)amino, di-(1-methyl-1-ethyl-n-pentyl)amino, di-(1-heptyl)amino, di-(2-heptyl)amino, di-(1-ethyl-1,2-dimethyl-n-propyl)amino, di-(1-ethyl-2,2-dimethyl-n-propyl)amino, di-(1-octyl)amino, di-(3-octyl)amino, di-(4-methyl-3-n-heptyl)amino, di-(6-methyl-2-n-heptyl)amino, di-(2-propyl-1-n-heptyl)amino, di-(2,4,4-trimethyl-1-n-pentyl)amino, di-(1-nonyl)amino, di-(2-nonyl)amino, di-(2,6-dimethyl-4-n-heptyl)amino, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)amino, di-(3,5,5-trimethyl-1-n-hexyl)amino, di-(1-decyl)amino, di-(2-decyl)amino, di-(4-decyl)amino, di(3,7-dimethyl-1-n-octyl)amino, di(3,7-dimethyl-3-n-octyl)amino or the like

Asymmetric C1-10dialkylamino may be linear or branched C3-10cycloalkylation and may represent a methyl, ethyl)amino, (methyl, n-propyl)amino, (methyl, isopropyl)amino, (methyl, cyclopropyl)amino, (methyl, n-butyl)amino, (methyl, isobutyl)amino, (methyl, sec-butyl)amino, (methyl, tert-butyl)amino, (methyl, n-pentyl)amino, (methyl, cyclopentyl)amino, (methyl, n-hexyl)amino, (methyl, cyclohexyl)amino, (ethyl, n-propyl)amino, (ethyl, isopropyl)amino, (ethyl, cyclopropyl)amino, (ethyl, n-butyl)amino, (ethyl, isobutyl)amino, (ethyl, sec-butyl)amino, (ethyl, tert-butyl)amino, (ethyl, n-pentyl)amino, (ethyl, cyclopentyl)amino, (ethyl, n-hexyl)amino, (ethyl, cyclohexyl)amino, n-propyl, isopropyl)amine is, (n-propyl, cyclopropyl)amino, n-propyl, n-butyl)amino, n-propyl, isobutyl)amino, n-propyl, sec-butyl)amino, n-propyl, tert-butyl)amino, n-propyl, n-pentyl)amino, n-propyl, cyclopentyl)amino, n-propyl, n-hexyl)amino, n-propyl, cyclohexyl)amino, (isopropyl, cyclopropyl)amino, (isopropyl n-butyl)amino, (isopropyl, isobutyl)amino, (isopropyl, sec-butyl)amino, (isopropyl, tert-butyl)amino, (isopropyl, n-pentyl)amino, (isopropyl, cyclopentyl)amino, (isopropyl, n-hexyl)amino, (isopropyl, cyclohexyl)amino, (cyclopropyl, n-butyl)amino, (cyclopropyl, isobutyl)amino, (cyclopropyl, sec-butyl)amino, (cyclopropyl, tert-butyl)amino, (cyclopropyl n-pentyl)amino, (cyclopropyl, cyclopentyl)amino, (cyclopropyl, n-hexyl)amino, (cyclopropyl, cyclohexyl)amino, n-butyl, isobutyl)amino, n-butyl, sec-butyl)amino, n-butyl, tert-butyl)amino, n-butyl, n-pentyl)amino, n-butyl, cyclopentyl)amino, n-butyl, n-hexyl)amino, n-butyl, cyclohexyl)amino, isobutyl, sec-butyl)amino, (isobutyl, tert-butyl)amino, (isobutyl, n-pentyl)amino, (isobutyl, cyclopentyl)amino, (isobutyl, n-hexyl)amino, (isobutyl, cyclohexyl), amino, (sec-butyl, tert-butyl)amino, (sec-butyl, n-pentyl)amino, (sec-butyl, cyclopentyl)amino, (sec-butyl, n-hexyl)amino, (sec-butyl, cyclohexyl)amino, (tert-butyl, n-pentyl)amino, (tert-butyl, cyclopentyl)amino, (tert-butyl, n-Huck who yl)amino, (tert-butyl, cyclohexyl)amino, (n-pentyl, cyclopentyl)amino, (n-pentyl, n-hexyl)amino, (n-pentyl, cyclohexyl)amino, (cyclopentyl, n-hexyl)amino, (cyclopentyl, cyclohexyl)amino, n-hexyl, cyclohexyl)amino, (methyl, n-heptyl)amino, (methyl, n-octyl)amino, (methyl, n-nonyl)amino, (methyl, n-decyl)amino, (methyl, n-heptyl)amino, (ethyl, n-octyl)amino, (ethyl, n-nonyl)amino, (ethyl, n-decyl)amino, etc.

C1-10alkylaminocarbonyl group can be linear or branched C3-10cycloalkylcarbonyl group and may represent methylaminomethyl, ethylaminomethyl, n-propylaminosulfonyl, isopropylaminocarbonyl, cyclopropanecarbonyl, n-butylaminoethyl, isobutylparaben, second-butylaminoethyl, tert-butylaminoethyl, cyclo-butylaminoethyl, 1-methylcyclopentanone, 2-methylcyclopentadienyl, n-intramyocardial, 1-methyl-n-butylaminoethyl, 2-methyl-n-butylaminoethyl, 3-methyl-n-butylaminoethyl, 1,1-dimethyl-n-propylaminoethyl, 1,2-dimethyl-n-propylaminoethyl, 2,2-dimethyl-n-propylaminoethyl, 1-ethyl-n-propylaminoethyl, cyclopentanecarbonyl, 1-methylcyclopentanone, 2-methylcyclopentanone, 3-methylcyclopentadienyl, 1,2-dimethylcyclopropanecarboxylic, 2,3-dimethylcyclopropanecarboxylic, 1-ethylcyclopropane noncarbonyl, 2-ethylcyclopentadienyl, n-mexiletineciclovir, 1-methyl-n-intramyocardial, 2-methyl-n-intramyocardial, 3-methyl-n-intramyocardial, 4-methyl-n-intramyocardial, 1,1-dimethyl-n-butylaminoethyl, 1,2-dimethyl-n-butylaminoethyl, 1,3-dimethyl-n-butylaminoethyl, 2,2-dimethyl-n-butylaminoethyl, 2,3-dimethyl-n-butylaminoethyl, 3,3-dimethyl-n-butylaminoethyl, 1-ethyl-n-butylaminoethyl, 2-ethyl-n-butylaminoethyl, 1,1,2-trimethyl-n-propylaminoethyl, 1,2,2-trimethyl-n-propylaminoethyl, 1-ethyl-1-methyl-n-propylaminoethyl, 1-ethyl-2-methyl-n-propylaminoethyl, cyclohexanecarbonyl, 1-methylcyclopentanone, 2-methylcyclopentadienyl, 3-methylcyclopentadienyl, 1-ethylcyclohexylamine, 2-ethylcyclopentadienyl, 3-ethylcyclopentadienyl, 1,2-dimethylcyclopropanecarboxylic, 1,3-dimethylcyclopropanecarboxylic, 2,2-dimethylcyclopropanecarboxylic, 2,3-dimethylcyclopropanecarboxylic, 2,4-dimethylcyclopropanecarboxylic, 3,3-dimethylcyclopropanecarboxylic, 1-n-propilco-propylaminoethyl, 2-n-propylcyclohexanone, 1-isopropylaminocarbonyl, 2-isopropylaminocarbonyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopropyl aminocarbonyl, 2-ethyl-1-methylcyclopentanone, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopentadienyl, 1-methyl-1-ethyl-n-intramyocardial, 1-getelementkey, 2-getelementkey, 1-ethyl-1,2-dimethyl-n-propylaminoethyl, 1-ethyl-2,2-dimethyl-n-propylaminoethyl, 1-octilinear, 3-octilinear, 4-methyl-3-n-getelementkey, 6-methyl-2-n-getelementkey, 2-propyl-1-n-getelementkey, 2,4,4-trimethyl-1-n-intramyocardial, 1-nonelimination, 2-nonelimination, 2,6-dimethyl-4-n-getelementkey, 3-ethyl-2,2-dimethyl-3-n-intramyocardial, 3,5,5-trimethyl-1-n-mexiletineciclovir, 1-decrimination, 2-decrimination, 4-decrimination, 3,7-dimethyl-1-n-octilinear, 3,7-dimethyl-3-n-octilinear etc.

C1-10dialkylaminoalkyl group can be symmetric or asymmetric. Symmetric C1-10dialkylaminoalkyl group can be linear or branched C3-10cycloalkylcarbonyl group and may represent dimethylaminoethyl, diethylaminoethyl, di-n-propylaminoethyl, diisopropylaminoethanol, dicyclopentadienyl, di-n-butylaminoethyl, diisobutylamine, di-sec-butylaminoethyl, di-tert-butylaminoethyl, dicyclopentadienyl, di-(1-methylcyclopropyl)amino ronil, di-(2-methylcyclopropyl)aminocarbonyl, di-n-intramyocardial, di-(1-methyl-n-butyl)aminocarbonyl, di-(2-methyl-n-butyl)aminocarbonyl, di-(3-methyl-n-butyl)aminocarbonyl, di-(1,1-dimethyl-n-propyl)aminocarbonyl, di-(1,2-dimethyl-n-propyl)aminocarbonyl, di-(2,2-dimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-n-propyl)aminocarbonyl, dicyclopentadienyl, di-(1-methylcyclobutene)aminocarbonyl, di-(2-methylcyclobutane)aminocarbonyl, di-(3-methylcyclobutene)aminocarbonyl, di-(1,2-dimethylcyclopropene)aminocarbonyl, di-(2,3-dimethylcyclopropane)aminocarbonyl, di-(1-ethylcyclopropane)aminocarbonyl, di-(2-ethylcyclopropane)aminocarbonyl, di-n-mexiletineciclovir, di-(1-methyl-n-pentyl)aminocarbonyl, di-(2-methyl-n-pentyl)aminocarbonyl, di-(3-methyl-n-pentyl)aminocarbonyl, di-(4-methyl-n-pentyl)aminocarbonyl, di-(1,1-dimethyl-n-butyl)aminocarbonyl, di-(1,2-dimethyl-n-butyl)aminocarbonyl, di-(1,3-dimethyl-n-butyl)aminocarbonyl, di-(2,2-dimethyl-n-butyl)aminocarbonyl, di-(2,3-dimethyl-n-butyl)aminocarbonyl, di-(3,3-dimethyl-n-butyl)aminocarbonyl, di-(1-ethyl-n-butyl)aminocarbonyl, di-(2-ethyl-n-butyl)aminocarbonyl, di-(1,1,2-trimethyl-n-propyl)aminocarbonyl, di-(1,2,2-trimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-1-methyl-n-propyl)aminocarbonyl, di-(1-ethyl-2-methyl-n-propyl)aminocarbonyl, dicyclohexylamine, di-(1-methylcyclopentene)aminocarbonyl, di-(2-methylcyclopentene)aminaka boil, di-(3-methylcyclopentene)aminocarbonyl, di-(1-ethylcyclohexyl)aminocarbonyl, di-(2-ethylcyclohexyl)aminocarbonyl, di-(3-ethylcyclohexyl)aminocarbonyl, di-(1,2-dimethylcyclobutyl)aminocarbonyl, di-(1,3-dimethylcyclobutyl)aminocarbonyl, di-(2,2-dimethylcyclobutyl)aminocarbonyl, di-(2,3-dimethylcyclobutyl)aminocarbonyl, di-(2,4-dimethylcyclobutyl)aminocarbonyl, di-(3,3-dimethylcyclobutyl)aminocarbonyl, di-(1-n-propylcyclohexyl)aminocarbonyl di-(2-n-propylcyclohexyl)aminocarbonyl, di-(1-isopropylcyclohexane)aminocarbonyl, di-(2-isopropylcyclohexane)aminocarbonyl, di-(1,2,2-trimethylpropyl)aminocarbonyl, di-(1,2,3-trimethylpropyl)aminocarbonyl, di-(2,2,3-trimethylpropyl)aminocarbonyl, di-(1-ethyl-2-methylcyclopropyl)aminocarbonyl, di-(2-ethyl-1-methylcyclopropyl)aminocarbonyl, di-(2-ethyl-2-methylcyclopropyl)aminocarbonyl, di-(2-ethyl-3-methylcyclopropyl)aminocarbonyl, di-(1-methyl-1-ethyl-n-pentyl)aminocarbonyl, di-(1-heptyl)aminocarbonyl, di-(2-heptyl)aminocarbonyl, di-(1-ethyl-1,2-dimethyl-n-propyl)aminocarbonyl, di-(1-ethyl-2,2-dimethyl-n-propyl)aminocarbonyl, di-(1-octyl)aminocarbonyl, di-(3-octyl)aminocarbonyl, di-(4-methyl-3-n-heptyl)aminocarbonyl, di-(6-methyl-2-n-heptyl)aminocarbonyl, di-(2-propyl-1-n-heptyl)aminocarbonyl, di-(2,4,4-trimethyl-1-n-pentyl)aminocarbonyl, di-(1-nonyl)aminocarbonyl, di-(2-nonyl)aminocarbonyl, di-(2,6-dimethyl-4-n-heptyl)am noncarbonyl, di-(3-ethyl-2,2-dimethyl-3-n-pentyl)aminocarbonyl, di-(3,5,5-trimethyl-1-n-hexyl)aminocarbonyl, di-(1-decyl)aminocarbonyl, di-(2-decyl)aminocarbonyl, di-(4-decyl)aminocarbonyl, di-(3,7-dimethyl-1-n-octyl)aminocarbonyl, di-(3,7-dimethyl-3-n-octyl)aminocarbonyl etc.

Asymmetric C1-10dialkylaminoalkyl group can be linear or branched C3-10cycloalkylcarbonyl group and may represent a methyl, ethyl)aminocarbonyl, (methyl, n-propyl)aminocarbonyl, (methyl, isopropyl)aminocarbonyl, (methyl, cyclopropyl)aminocarbonyl, (methyl, n-butyl)aminocarbonyl, (methyl, isobutyl)aminocarbonyl, (methyl, sec-butyl)aminocarbonyl, (methyl, tert-butyl)aminocarbonyl, (methyl, n-pentyl)aminocarbonyl, (methyl, cyclopentyl)aminocarbonyl, (methyl, n-hexyl)aminocarbonyl, (methyl, cyclohexyl)aminocarbonyl, (ethyl, n-propyl)aminocarbonyl, (ethyl, isopropyl)aminocarbonyl, (ethyl cyclopropyl)aminocarbonyl, (ethyl, n-butyl)aminocarbonyl, (ethyl, isobutyl)aminocarbonyl, (ethyl, sec-butyl)aminocarbonyl, (ethyl, tert-butyl)aminocarbonyl, (ethyl, n-pentyl)aminocarbonyl, (ethyl cyclopentyl)aminocarbonyl, (ethyl, n-hexyl)aminocarbonyl, (ethyl, cyclohexyl)aminocarbonyl, n-propyl, isopropyl)aminocarbonyl, (n-propyl, cyclopropyl)aminocarbonyl, n-propyl, n-butyl)aminocarbonyl, n-propyl, isobutyl)aminocarbonyl, n-propyl, sec-b is Teal)aminocarbonyl, (n-propyl, tert-butyl)aminocarbonyl, n-propyl, n-pentyl)aminocarbonyl, n-propyl, cyclopentyl)aminocarbonyl, n-propyl, n-hexyl)aminocarbonyl, n-propyl, cyclohexyl)aminocarbonyl, isopropyl, cyclopropyl)aminocarbonyl, isopropyl, n-butyl)aminocarbonyl, (isopropyl, isobutyl)aminocarbonyl, isopropyl, sec-butyl)aminocarbonyl, (isopropyl, tert-butyl)aminocarbonyl, isopropyl, n-pentyl)aminocarbonyl(isopropyl, cyclopentyl)aminocarbonyl, isopropyl, n-hexyl)aminocarbonyl, isopropyl, cyclohexyl)aminocarbonyl, (cyclopropyl, n-butyl)aminocarbonyl, (cyclopropyl, isobutyl)aminocarbonyl, (cyclopropyl, sec-butyl)aminocarbonyl, (cyclopropyl, tert-butyl)aminocarbonyl, (cyclopropyl, n-pentyl)aminocarbonyl, (cyclopropyl, cyclopentyl)aminocarbonyl, (cyclopropyl, n-hexyl)aminocarbonyl, (cyclopropyl, cyclohexyl)aminocarbonyl, n-butyl, isobutyl)aminocarbonyl, (n-butyl, sec-butyl)aminocarbonyl, n-butyl, tert-butyl)aminocarbonyl, n-butyl, n-pentyl)aminocarbonyl, n-butyl, cyclopentyl)aminocarbonyl, n-butyl, n-hexyl)aminocarbonyl, n-butyl, cyclohexyl)aminocarbonyl, isobutyl, sec-butyl)aminocarbonyl, isobutyl, tert-butyl)aminocarbonyl, isobutyl, n-pentyl)aminocarbonyl, isobutyl, cyclopentyl)aminocarbonyl, isobutyl, n-hexyl)aminocarbonyl, isobutyl, cyclohexyl)aminocarbonyl, (sec-butyl, tert-butyl)is aminocarbonyl, (sec-butyl, n-pentyl)aminocarbonyl, (sec-butyl, cyclopentyl)aminocarbonyl, (sec-butyl, n-hexyl)aminocarbonyl, (sec-butyl, cyclohexyl)aminocarbonyl, (tert-butyl, n-pentyl)aminocarbonyl, (tert-butyl, cyclopentyl)aminocarbonyl, (tert-butyl, n-hexyl)aminocarbonyl, (tert-butyl, cyclohexyl)aminocarbonyl, (n-pentyl, cyclopentyl)aminocarbonyl, (n-pentyl, n-hexyl)aminocarbonyl, (n-pentyl, cyclohexyl), aminocarbonyl, (cyclopentyl, n-hexyl)aminocarbonyl, (cyclopentyl, cyclohexyl)aminocarbonyl, n-hexyl, cyclohexyl)aminocarbonyl, (methyl, n-heptyl)aminocarbonyl, (methyl, n-octyl)aminocarbonyl, (methyl, n-nonyl)aminocarbonyl, (methyl, n-decyl)aminocarbonyl, (methyl, n-heptyl)aminocarbonyl, (ethyl, n-octyl)aminocarbonyl, (ethyl, n-nonyl)aminocarbonyl, (ethyl n-decyl)aminocarbonyl etc.

C1-6alkylaminocarbonyl group can be linear or branched C3-6cycloalkylcarbonyl group and can be methylaminomethyl, ethylaminomethyl, n-propylaminosulfonyl, isopropylaminocarbonyl, cyclopropanesulfonyl, n-butylaminoethyl, sibutraminesolution, second-butylaminoethyl, tert-butylaminoethyl, cyclobutylmethyl, 1-methylcyclopentanone, 2-methylcyclopentadienyl, n-intramyocellular, 1-methyl-n-butylimidazole is, 2-methyl-n-butylaminoethyl, 3-methyl-n-butylaminoethyl, 1,1-dimethyl-n-propylaminosulfonyl, 1,2-dimethyl-n-propylaminosulfonyl, 2,2-dimethyl-n-propylaminosulfonyl, 1-ethyl-n-propylaminosulfonyl, cyclopentylmethyl, 1-methylcyclopentadienyl, 2-methylcyclopentadienyl, 3-methylcyclopentadienyl, 1,2-dimethylcyclopropanecarboxylic, 2,3-dimethylcyclopropanecarboxylic, 1-ethylcyclopentadienyl, 2-ethylcyclopentadienyl, n-exelonexelon, 1-methyl-n-intramyocellular, 2-methyl-n-intramyocellular, 3-methyl-n-intramyocellular, 4-methyl-n-intramyocellular, 1,1-dimethyl-n-butylaminoethyl, 1,2-dimethyl-n-butylaminoethyl, 1,3-dimethyl-n-butylaminoethyl, 2,2-dimethyl-n-butylaminoethyl, 2,3-dimethyl-n-butylaminoethyl, 3,3-dimethyl-n-butylaminoethyl, 1-ethyl-n-butylaminoethyl, 2-ethyl-n-butylaminoethyl, 1,1,2-trimethyl-n-propylaminosulfonyl, 1,2,2-trimethyl-n-propylaminosulfonyl, 1-ethyl-1-methyl-n-propylaminosulfonyl, 1-ethyl-2-methyl-n-propylaminosulfonyl, cyclohexanesulfonyl, 1-methylcyclopentanol, 2-methylcyclopentadienyl, 3-methylcyclopentanol, 1-ethylcyclopentadienyl, 2-ethylcyclopentadienyl, 3-ethylcyclopentadienyl, 1,2-dimethylcyclobutane, 1,3-dimeth cyclobutanecarbonyl, 2,2-dimethylcyclopropanecarboxylic, 2,3-dimethylcyclohexylamine, 2,4-dimethylcyclobutane, 3,3-dimethylcyclopropanecarboxylic, 1-n-propylcyclohexanone, 2-n-propyltrichlorosilane, 1-isopropylcyclopentadienyl, 2-isopropylcyclopentadienyl, 1,2,2-trimethylcyclopentanone, 1,2,3-trimethylcyclopentanone, 2,2,3-trimethylcyclopentanone, 1-ethyl-2-methylcyclopentanone, 2-ethyl-1-methylcyclopentanone, 2-ethyl-2-methylcyclopentanone, 2-ethyl-3-methylcyclopentadienyl etc.

C1-10alkylaminocarbonyl group can be linear or branched C3-10cycloalkylcarbonyl and, in addition to the above-mentioned groups may be a 1-methyl-1-ethyl-n-intramyocellular, 1-reptilescolleen, 2-reptilescolleen, 1-ethyl-1,2-dimethyl-n-propylaminosulfonyl, 1-ethyl-2,2-dimethyl-n-propylaminosulfonyl, 1-octylimidazolium, 3-octylimidazolium, 4-methyl-3-n-reptilescolleen, 6-methyl-2-n-reptilescolleen, 2-propyl-1-n-reptilescolleen, 2,4,4-trimethyl-1-n-intramyocellular, 1-nonelimination, 2-nonelimination, 2,6-dimethyl-4-n-reptilescolleen, 3-ethyl-2,2-dimethyl-3-n-intramyocellular, 3,5,5-trimethyl-1-n-exelonexelon, 1-Jan is aminosulfonyl, 2-decriminalises, 4-decriminalises, 3,7-dimethyl-1-n-octylimidazolium, 3,7-dimethyl-3-n-octylimidazolium, cycloheptylmethyl, cyclooctylmethyl, 1-methylcyclohexylamine, 2-methylcyclohexylamine, 3-methylcyclohexylamine, 1,2-dimethylcyclohexylamine, 1-ethylcyclohexylamine, 1-methylcyclopentanol, 2-methylcyclopentadienyl, 3-methylcyclopentadienyl or similar

The protective group in the protected hydroxyl group may be a C1-4alkoxymethyl group (such as MOM: methoxymethyl, MEM: 2-methoxyethoxymethyl, ethoxyethyl, n-propoxymethyl, isopropoxide, n-butoxymethyl, iBM: isobutylacetate, BUM: tert-butoxymethyl, POM: pivaloyloxymethyl, SEM: trimethylsilylethynyl and the like, preferably, C1-2alkoxymethyl etc.), aryloxyalkyl (such as BOM: benzyloxyethyl, PMBM: p-methoxyethoxymethyl, p-AOM: the p-antilocality and the like, preferably benzyloxyethyl), C1-4acylaminoalkyl group (such as dimethylaminomethyl), substituted acetamidomethyl group (such as Acm: atsetamidometil, Tacm: trimethylacetamido and the like), substituted thiomethyl group (such as MTM: methylthiomethyl, PTM: phenylthiomethyl, Btm: benzyldimethyl and the like), a carboxyl group, a C1-7acyl group (taqulik formyl, acetyl, peracetyl, divercity, TRIFLUOROACETYL, chloroacetyl, dichloroacetyl, trichloroacetyl, propionyl, Pv: pivaloyl, tiglyl etc.), arylcarbamoyl group (such as benzoyl, p-bromobenzoyl, 2,3-dinitrobenzoyl, benzoylformate, benzoylpropionic, phenylpropionyl etc.), C1-4alkoxycarbonyl group (such as methoxycarbonyl, etoxycarbonyl, n-propoxycarbonyl, ISO-propoxycarbonyl, n-butoxycarbonyl, ISO-butoxycarbonyl, BOC: tert-butoxycarbonyl, AOC: tert-aryloxyalkyl, VOC: vinyloxycarbonyl, AOC: allyloxycarbonyl, Teoc: 2-(trimethylsilyl)etoxycarbonyl, Troc: 2,2,2-trichlorocyanuric and the like, preferably BOC, and the like), aryloxyalkyl group (such as Z: benzyloxycarbonyl, p-nitrobenzenesulfonyl, MOZ: p-methoxybenzenesulfonyl etc.), C1-4alkylaminocarbonyl group (such as methylcarbamoyl, Ec: ethylcarbitol, n-propellerblades etc.), arylaminomethylene group (such as phenylcarbamoyl etc.), trialkylsilyl group (such as TMS: trimethylsilyl, TES: triethylsilyl, TIPS: triisopropylsilyl, DEIPS: diethylenediamine, DMIPS: dimethylazobenzene, DTBMS: di-tert-butylmethylether, IPDMS: isopropylimidazole, TBDMS: tert-butyldimethylsilyl, TDS: taxidermically and the like, preferably, tert-butyldimethylsilyl etc.), trialkylsilyl group (such as DPMS: diphenylmethylsilane, TBDPS: tert-bout divinycell, TBMPS: tert-butyldimethylsilyl, TPS: triphenylsilane etc.), alkylsulfonyl group (such as Ms: methanesulfonyl, econsultancy etc) or arylsulfonyl group (such as benzazolyl, Ts: p-toluensulfonyl, p-chlorobenzenesulfonyl, MBS: p-methoxybenzenesulfonyl, m-nitrobenzenesulfonyl, o-nitrobenzenesulfonyl, p-nitrobenzenesulfonyl, 2,4-nitrobenzenesulfonyl, iMds: 2,6-dimethoxy-4-methylbenzenesulfonyl, Mds: 2,6-dimethyl-4-methoxybenzenesulfonyl, Mtb: 2,4,6-trimethoxybenzylamine, Mte: 2,3,5,6-tetramethyl-4-methoxybenzenesulfonyl, Mtr: 2,3,6-trimethyl-4-methoxybenzenesulfonyl, Mts: 2,4,6-trimethylbenzenesulfonyl, Pme: pentamethylbenzyl etc).

In addition, there may be 1-methyl-1-ethoxyethylene group, 1-ethoxyethylene group, 2,2,2-trichlorethylene group, 2-trimethylsilyloxy, tert-bucilina group, allyl group, benzyl group, p-methoxybenzyl group, 2,4-dinitroaniline group, p-chloraniline group, p-metoksifenilny group, tetrahydropyranyl group and tetrahydrofuranyl group.

Specific preferred examples of the substituent R1represent a phenyl group, thienyl groups (a 2-thienyl group and 3-thienyl group), foreline group (2-follow group and 3-follow group), pyridazinyl group (3-pyridazinyl group and 4-pyridazinyl group), rideline group (2-pyridyloxy group, 3-pyridyloxy group and 4-pyridyloxy group), chinoline group (2-pinolillo group, 3-pinolillo group, 4-pinolillo group, 5-pinolillo group, 6-pinolillo group, 7-pinolillo group and 8-pinolillo group) and ethanolamine group (1-izohinolinove group, 3-izohinolinove group, 4-izohinolinove group, 5-izohinolinove group, 6-izohinolinove group, 7-izohinolinove group and 8-izohinolinove group), optionally substituted by one or more of the following substituents.

Deputies: C1-10alkyl group, a halogen atom, a C1-10alkyl group substituted by one or more halogen atoms, the nitro-group, amino group, amino group, substituted by one or two C1-10alkyl group, amino group, substituted C1-10alkylcarboxylic group, Tolna group, substituted C1-10alkyl group, Tolna group, substituted C1-10alkylcarboxylic group, a hydroxyl group, a C1-6alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group.

Particularly preferred examples of the substituent R1represent a phenyl group, thienyl groups (a 2-thienyl group and 3-thienyl group), foreline group (2-follow group and 3-follow group), pyridazinyl GRU is p (3-pyridazinyl group and 4-pyridazinyl group), peredelnye group (2-pyridyloxy group, 3-pyridyloxy group and 4-pyridyloxy group), chinoline group (2-pinolillo group, 3-pinolillo group, 4-pinolillo group, 5-pinolillo group, 6-pinolillo group, 7-pinolillo group and 8-pinolillo group) and ethanolamine group (1-izohinolinove group, 3-izohinolinove group, 4-izohinolinove group, 5-izohinolinove group, 6-izohinolinove group, 7-izohinolinove group and 8-izohinolinove group), optionally substituted by one or more of the following substituents.

Substituents: methyl group, tert-bucilina group, triptorelin group, chlorine atom, fluorine atom, bromine atom, tripterocarpa, a methoxy group, methylaminopropyl, dimethylaminopropyl, tert-butylacrylate and tert-butylamino.

More preferred specific examples of the substituents are 3-methylphenyl group, 4-methylphenyl group, 3,4-dimethylphenyl group, 4-bromperidol group, 4-triphtalocyaninine group, 3-tert-butylphenyl group, 4-tert-butylphenyl group, 3-triftormetilfullerenov group, 4-triftormetilfullerenov group, 4-triphtalocyaninine group, 3,4-dateformatstring group, 3-chloraniline group, 4-chloraniline group, 3-florfenicol group, 4-florfenicol group, 3,4-dichloraniline g is the SCP, 4-metoksifenilny group, 4-methylaminophenol group, 3-methylcytidine group, 4-methylcytidine group, 3,4-dimethylaniline group, 3-tert-butylaniline group, 4-tert-butylaniline group, 3-trifloromethyl group, 4-trifloromethyl group, 3,4-dateformatstring group, 3-chloraniline group, 4-chloraniline group, 3-forceinline group, 4-forceinline group, 3,4-dichloraniline group, 4-methoxytyramine group, 4-methylenedianiline group, 3-methylphenylene group, 4-methylphenylene group, 3,4-dimethylpyridine group, 3-tert-butylphenol group, 4-tert-butylphenol group, 3-triftormetilfullerenov group, 4-triftormetilfullerenov group, 3,4-dateformatstring group, 3-chlorphenol group, 4-chlorphenol group, 3-forfollow group, 4-forfollow group, 3,4-dichloropyridine group, 4-methoxypyridine group, 4-methylaminophenol group, 5-chloropyridinyl group, 5-methylpyridinium group, 5-methoxypyridazine group, 4-chloropyridinyl group, 4-methylpyridinium group, 4-methoxypyridazine group, 4-tert-butoxybenzoyl group, etc.

Specific preferred examples of L1represent a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2N-CH2Ph, etc. and especially prepact the positive examples are the connection, CH2, an oxygen atom, a sulfur atom, NH, NMe, etc.

Specific preferred examples of the substituent R2represent hydrogen, methyl group, ethyl group, n-sawn group, isopropyl group, tert-boutelou group and phenyl group (methyl group, ethyl group, n-sawn group, isopropyl group, tert-bucilina group and the phenyl group optionally may be substituted amino group, monomethylamine, dimethylaminopropoxy, monoethyleneglycol, diethylaminopropyl, a methoxy group, ethoxypropane, methoxycarbonyl group, ethoxycarbonyl group, methylcarbonate, ethylcarboxylate, methylcarbaniloyloxy or ethylcarbodiimide), and particularly preferable examples are a hydrogen, methyl group, ethyl group, n-sawn group, ISO-propyl group, tert-boutelou group, phenyl group, etc.

Specific preferred examples of L2represent a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2N-CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe, etc.

Specific preferred examples of L3represent a bond, CH2, an oxygen atom, a sulfur atom, NH, NH-OH, N-Me, N-CHO, HMe, CMe2N-CH2PH and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe, etc.

Specific preferred examples of the substituent R3represents a C2-14aryl group which is optionally substituted by one or more substituents selected from the following list And substituents, and optionally may be substituted by one or more substituents independently selected from the following list B substituents, and substituted C2-14aryl group, which optionally can be substituted by one or more substituents selected from the following list B substituents.

Set And deputies:

can be a-W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), ka is every W 2and W3independently represent a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-4 aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group, amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic nogroup, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted od is Oh or multiple C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10al is ylcarbonyl group optionally substituted by one or more substituents, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms is in) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl the x groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more of the Deputy is mi, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), or R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkyls is Beniaminov, amino, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group, a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C-6 alkyline group, C1-10alkylcarboxylic and C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups of cyano groups, of halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic,C 1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6 alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted for the one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or substituted C2-9heterocyclic group (substituted C2-9heterocyclic group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonic the amino groups, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group, C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14 aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))and C1-6alkyl groups (the alkyl groups of C1-6optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, the atom is in the halogen-free, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylarylsulfonate, C1-10alkylaminocarbonyl groups, C1-10alkylsulfonamides, C1-10thioalkyl groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylarylsulfonate, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10al is oxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and-W5(where W5represents the SO2R42, SOR42, COR42 (where R42represents a hydrogen atom, a hydroxyl group, or NR43R44and each of R43and R44independently represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or bore alkemi halogen atoms)), or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), or R43and R44taken together, represent -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6and kinilow group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), or C2-14aryl group (aryl group C2-14optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups m which may be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5)) or W4and W4are as defined above)).

Set B substituents:

can represent hydrogen atoms, hydroxyl groups, amino groups, tirinya group, nitro group, ceanography, halogen atoms, carboxyl groups, carbamoyl group, sulfamoyl group, sulfopropyl, formyl group, C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl the e group (C 1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14alloc is igroup (C 2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy).

Specific especially preferred examples of the substituent R3represents a C2-14aryl groups that are optionally substituted by one or more substituents selected from the following list And substituents, and optionally can be substituted by one or more substituents independently selected from the following list B substituents.

Set And deputies:

can be a C1-6alkyl group, a C2-6alkeneamine group and C2-6alkyline group (C1-6alkyl group, a C2-6alkeneamine group and C2-6alkyne the global group optionally substituted by one or more substituents, selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above) and-W5(where W5represents the SO2R42, SOR42, COR42(where R42represents a hydrogen atom, a hydroxyl group, or NR43R44, R43is the same as R6, R44is the same as R7and R6and R7are as defined above), or W4and W4are as defined above)), C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents independently represented as-V2 (where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from C2-9heterocyclic groups (C2-9heterocyclic group optionally substituted by one or more substituents independently represented as-V3(where V3is the same as V1and V1is the same as defined above))), C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from the group consisting of amino groups (amino groups substituted C1-10alkyl group (alkyl group C1-10optionally substituted by one or more substituents independently represented as-V3(where V3is the same ka is V 1and V1is the same as defined above)) and C2-9heterocyclic group or a C2-14aryl group (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V4(where V4is the same as V1and V1is the same as defined above))), amino groups, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl group and tirinya groups (amino, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl group and tirinya group optionally substituted by one or more C2-9heterocyclic groups or one or more C2-14aryl groups (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V5(where V5is the same as V1and V1is as defined above)))).

Set B substituents:

can represent hydrogen atoms, hydroxyl groups, amino groups, ialnye group, nitro, ceanography, halogen atoms, carboxyl groups, carbamoyl group, sulfamoyl group, sulfopropyl, formyl group, C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group, and C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14anilox the groups).

Additional specific preferred examples of the substituent R3represent a phenyl group, thienyl groups (a 2-thienyl group and 3-thienyl group), foreline group (2-follow group and 3-follow group), pyridazinyl group (3-pyridazinyl group and 4-pyridazinyl group), peredelnye group (2-pyridyloxy group, 3-pyridyloxy group and 4-pyridyloxy group), chinoline group (2-pinolillo group, 3-pinolillo group, 4-pinolillo group, 5-pinolillo group, 6-pinolillo group, 7-pinolillo group and 8-pinolillo group) and ethanolamine group (1-izohinolinove group, 3-izohinolinove group, 4-izohinolinove group, 5-izohinolinove group, 6-izohinolinove group, 7-izohinolinove group and 8-izohinolinove group)that is substituted by one or more substituents selected from the following list And substituents, and optionally can be substituted by one or more substituents independently selected from the following list B substituents, and the following structures, which may not necessarily be substituted by one or more substituents selected from the following list B substituents.

Set And deputies:

can be a SO2R28, SOR28or COR28(where R28PR is dstanley a NR 29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy the PU (C 2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group, amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, atoms Gal the genes hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optional mo the ut to be substituted by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkene is lnyh groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C110 alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxide onlnie group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl group is, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), or R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6and killname groups (C 1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group, a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group, with the standing of the carboxyl groups, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl what's groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10and what of maxigrip, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups is C 2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides the dust, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, NIT is AGroup, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or substituted C2-9heterocyclic group (substituted C2-9heterocyclic group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10Alcock carbanilide group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkiline the group may be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and C1-6alkyl groups (C1-6alkyl group optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkoxygroup, C1-10alkylcarboxylic g the SCP, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylarylsulfonate, C1-10alkylaminocarbonyl groups, C1-10alkylsulfonamides, C1-10thioalkyl groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylarylsulfonate, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted one or several and C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and-W5(where W5represents the SO2R42, SOR42, COR42(where R42represents a hydrogen atom, a hydroxyl group, or NR43R44and each of R43and R44independently represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6akinlosotu, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted one is m or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), or R43and R44taken together, represent -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10Ala is carbonyloxy, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkyls is boilershop, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5)), SO2R28, SOR28or COR28(where R28is the same as defined above))).

Set B substituents:

can represent hydrogen atoms, hydroxyl groups, amino groups, tirinya group, nitro group, ceanography, halogen atoms, carboxyl groups, carbamoyl group, sulfamoyl group, sulfopropyl, formyl group, C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10Ala the selected groups (C 1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy).

Specific preferred examples of L4represent a bond, CH2, an oxygen atom, a sulfur atom, NH, N-Me, N-CHO, CHMe, CMe2N-CH2Ph and the like, and particularly preferable examples are a bond, CH2, an oxygen atom, a sulfur atom, NH, NMe, etc.

Specific preferred examples of X are a HE, SH, NH2, OMe, SMe, NHMe, NHEt, NH-CHO, NH-CH2Ph-OCH2Ph, SCH2Ph, OC(=O)CH3SC(=O)CH3, NHC(=O)CH3and the like, and particularly preferred examples are HE, SH, NH2etc.

Specific preferred examples of Y are an oxygen atom, a sulfur atom, NH, N-OH, N-CHO, N-Me, N-CH2Ph, N-OMe, N-OCH2Ph and the like, and particularly preferred examples represent an oxygen atom, a sulfur atom, NH, N-OH, etc.

Connection, approaching the s as activator receptor thrombopoetin, preventive, therapeutic or improving agent against diseases for which treatment is effective activation of the receptor thrombopoetin, and the agent that increases the number of platelets, according to the present invention are the following.

1. Compounds represented by formula (1)in which A represents a nitrogen atom, and B represents a sulfur atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

2. Compounds represented by formula (1)in which A represents a nitrogen atom, and B represents an oxygen atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

3. Compounds represented by formula (1)in which A represents a nitrogen atom, and B represents NR9different from NH (where R9represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic the group, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkitab is relaxerror, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

4. Compounds represented by formula (1)in which A represents CR4(where R4represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol group or a C2-6alkenylphenol what Ruppel), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or two C2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, a cyano, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14aryl is syrupy can be substituted by one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10/sub> alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), SO2R5, SOR5or COR5(where R5represents a hydroxyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more atom of the mi by halogen or by one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or dis 1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or NR6R7(where each of R6and R7independently represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkilinity can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C 2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or R6and R7taken together, means -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, Csub> 1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-1 alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5))))and B represents an oxygen atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

5. Compounds represented by formula (1)in which A represents CR4(where R4represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol group or a C2-6alkenylphenol group), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or the two C 2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, a cyano, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally can be replaced the ene by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14alloc is igroup), SO2R5, SOR5or COR5(where R5represents a hydroxyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be zames is by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or NR6R7(where each of R6and R7independently represents a hydrogen atom, hydroxyl group, formyl group, C 1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents, selected from the group sotoyama is from C 1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or R6and R7taken together, means -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10the alkyl group is a, C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl group is, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5))))and B is a sulfur atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

6. Compounds represented by formula (1)in which A represents CR4(where R4represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol group or a C2-6alkenylphenol group), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or two C2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, a cyano, C1-10alkyl group, a C2-6alkenylphenol group, C2-6 alkylamino group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one the or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), SO2R5, SOR5or COR5(where R5represents a hydroxyl group, a C1-10alkyl group, a C2-6alkenyl the second group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, Atovulloyev, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or NR6R7(where each of R6and R7independently represent a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic is, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms, C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or R6and R7taken together, means -(CH2)m1-E-(CH2)m2- (where E represents an oxygen atom, a sulfur atom, CR26R27(where each of R26and R27independently represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype, a hydroxyl group or a protected hydroxyl group) or NR8(where R8represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic is a sigroup, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkyls is boilershop, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), and each of m1 and m2 independently is an integer from 0 to 5 provided that m1+m2 is 3, 4 or 5))))and B represents NR9(where R9represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected who's hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) or C2-14alloctype (C2-14alloctype optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more atoms of Galaga the s) C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

7. Compounds represented by formula (1) PP), 5) or 6)in which A represents CR37(where R37represents a hydrogen atom, a hydroxyl group (the hydroxyl group may be substituted C2-6alkenylphenol or C2-6alkenylphenol group), Tilney group (Tolna group may be substituted C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkenylphenol group or a C1-10alkylcarboxylic group), amino group (the amino group may be substituted by one or two C2-6alkenylamine groups or one or two C2-6alkenylamine groups), a formyl group, a halogen atom, a nitro-group, a cyano, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10ALCO is the system of groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic and mono - or di-C1-10alkylamino can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups), SO2R38, SOR38or COR38(where R38represents a hydroxyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms))), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds Ilia the solvate. The elements in the respective substituents R37and R38are the same as elements in the respective substituents R1-R36.

8. Compounds represented by formula (1) through 3) or 6), in which B represents NR39(where R39represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group may be substituted by one or more substituents selected from the group consisting of carboxyl groups, halogen atoms, nitro groups and cyano groups), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype can be substituted by one or more substituents selected from the group consisting of C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik GRU is p, carboxyl groups, nitro groups, cyano groups and halogen atoms)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate. The items in the substituent R39are the same as elements in the respective substituents R1-R36.

9. Compounds represented by formula (1) according to items 1), 2), 3), 4), 5), 6), 7) or 8), in which L1represents the relationship; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

10. Compounds represented by formula (1) according to items 1), 2), 3), 4), 5), 6), 7), 8) or 9), in which L2are the connection; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

11. Compounds represented by formula (1) according to items 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10), in which L3represents NR19(where R19represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl the group, C1-10alkoxygroup and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic the SCP, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

12. Connections to items 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10), in which L3represents NH; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

13. Connections to items 1), 2), 3), 4), 5), 6), 7), 8), 9) or 10), in which L3represents CH2; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

14. Connection PP), 12) or (13), in which L4represents the relationship; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

15. Connection PP), 12) or (13), in which L4represents NR22(where R22represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10Alki the other group, C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)) or C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl group is, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

16. Connection PP), 12) or (13), in which L4represents NH; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

17. Connection PP), 12) or (13), in which L4represents CH2; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

18. Connection PP), 15), 16) or 17), in which R2represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-10alkoxygroup optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, atoms of Galaga is s, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

19. Connection PP), 15), 16) or 17), in which R2represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-3alkoxygroup (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group and C1-3alcox the group optionally can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, phenyl groups and fenoxaprop (phenyl groups and fenoxaprop can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms)or one or more halogen atoms), phenyl group, or fenoxaprop (phenyl group and fenoxaprop can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

20. Connection PP), 15), 16) or 17), in which R2represents a hydrogen atom, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group (C1-10alkyl group, a C2-6Alchemilla group and C2-6Alchemilla group optional is about can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, a hydroxyl group and a protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

21. Connection PP), 15), 16) or 17), in which R2represents a hydrogen atom, or a C1-6alkyl group, (C1-6alkyl group optionally may be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, a hydroxyl group and a protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

22. Connection PP), 15), 16) or 17), in which R2represents a hydrogen atom or a C1-3alkyl group, (C1-3alkyl is group optionally may be substituted by one or more substituents, selected from the group consisting of halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, a hydroxyl group and a protected hydroxyl groups), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

23. Connection PP), 19), 20), 21) or 22), in which R1represents a C2-14aryl group (C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkoxycarbonyl group and C1-10alkylcarboxylic optionally can be substituted by one or more replace the s, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group, a C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or more substituents selected from the group consisting of formyl group, a C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10 alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

24. Connection PP), 19), 20), 21) or 22), in which R1represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, chinalilly the group and izochinolina group optionally can be substituted by one or more substituents, selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkoxycarbonyl group and C1-10alkylcarboxylic optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more atoms is of Loginov) or one or more halogen atoms)), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or more substituents selected from the group consisting of formyl group, a C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

25. Connection p. the .18), 19), 20), 21) or 22), in which R1represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group and izochinolina group optionally can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic optionally can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups), C2-14aryl group, a C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be the ü substituted by one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or more substituents selected from the group consisting of formyl group, a C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

26. Connection PP), 19), 20), 21) or 22), in which R1represents a phenyl group (the phenyl group optionally may be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-62-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or more substituents selected from the group consisting of FD is mile groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6the alkyl group may be substituted by one or more halogen atoms) or one or more halogen atoms)))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

27. Connection PP), 19), 20), 21) or 22), in which R1represents a phenyl group (the phenyl group optionally may be substituted by one or more substituents selected from the group which, consisting of halogen atoms, carboxyl groups, nitro groups, formyl groups, cyano groups, hydroxyl groups, protected hydroxyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic optionally can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups and cyano groups), C2-14aryl group, a C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms), tylnej groups and amino groups (tirinya group and an amino group optionally can be substituted by one or more substituents selected from the group consisting of formyl group, a C1-10alkyl groups, C2-6alkenyl groups C 2-6etkinlik groups and C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of halogen atoms, carboxyl groups, nitro groups, cyano groups, hydroxyl groups and protected hydroxyl groups)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

28. Connection PP), 24), 25), 26) or 27), in which Y represents an oxygen atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

29. Connection PP), 24), 25), 26) or 27), in which Y represents a sulfur atom; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

30. Connection p) or 29), in which X represents a hydroxyl group; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

31. Connection PP), 29) or 30), in which R3represents a C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1predstavljaet a hydrogen atom, hydroxyl group, a protected hydroxyl group, amino group, Tilney group, a nitrogroup, cyano, halogen atom, carboxyl group, karbamoilnuyu group, sulfamoyl group, alphagroup, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10alkylcarboxylic group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides, C1-10thioalkyl group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10Tolkalina group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl group is, of sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino the SCP, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)) and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C 1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be Emesene one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group, amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6 alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carb is xilinix groups, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline g is uppy, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, atoms Gal the genes C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl what's groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminor is PP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32 represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl is lnyh groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10 alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, Aminov the SCP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5), or NR29R30as a whole, means the AET nitrogen-containing C 2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl group and C2-9heterocyclic group optionally can be substituted by one or more substituents, selected from the group consisting the th of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylboron is aminogroup, amino, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or substituted C2-9heterocyclic group (substituted C2-9heterocyclic group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkyl groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkoxygroup, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylsulfonamides, C1-10thioalkalimicrobium and C 2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, atoms, halogeno is, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1is the same as defined above), and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups and C2-6etkinlik groups (C1-6alkyl group, a C2-6alkeneamine group and C2-6alkyline group optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents independently represented as-V2(where V2is the same as V1and V1are the same as defined above) and-W5(where W5is with the fight SO 2R42, SOR42, COR42(where R42represents a hydrogen atom, a hydroxyl group, or NR43R44, R43is the same as R6, R44is the same as R7and R6and R7are as defined above), or W4and W4is the same as defined above))), C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1is the same as defined above), and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from C2-9heterocyclic groups (C2-9the heterocycle is ical group optionally substituted by one or more substituents, independently represented as-V3(where V3is the same as V1and V1is as defined above))))C2-14aryl group (C2-14aryl group optionally substituted by one or more substituents independently represented as-V1(where V1is the same as defined above), and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents independently represented as-V2(where V2is the same as V1and V1is the same as defined above), and one or more substituents selected from the group consisting of amino groups (amino groups substituted C1-10alkyl group, (C1-10alkyl group optionally substituted by one or more substituents independently represented as-V3(where V3is the same as V 1and V1is the same as defined above)) and C2-9heterocyclic group or a C2-14aryl group (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V4(where V4is the same as V1and V1is the same as defined above))), amino groups, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl groups, C1-10alkylsulfonyl groups, sulfanilic groups, sulfinyl groups and tylnej groups (amino, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl group and tirinya group optionally substituted by one or more C2-9heterocyclic groups or one or more C2-14aryl groups (C2-9heterocyclic group, and C2-14aryl group optionally substituted by one or more substituents independently represented as-V5(where V5is the same as V1and V1is as defined above)))))or substituted C2-14aryl group (substituted C2-14aryl group optionally may be substituted for the ne or more substituents, independently represented as-V1(where V1is the same as defined above)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

32. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alcok the group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl the groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamine the group, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10the alkyl is of ingroup, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-1 alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, saxeseni the hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group is s optionally can be substituted by one or more substituents, selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more of the likeme halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

33. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl GRU is p and C 1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C 1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14alloctype (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl g is PP, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkinyl the e group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, atoms ha is Oganov, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic,C 1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups and C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, with lfamily groups, of sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino,hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

34. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxy is the SCP can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represent a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino is, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alquiler is velociprey, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10 acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkali is boilershop, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

35. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl group, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented by C1-6alkyl groups (C1-6alkyl group optionally substituted by one who does more substituents, selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents independently represented as-V1(where V1is such as defined in claim 1) and-W5(where W5represents the SO2R42, SOR42, COR42(where R42represents a hydroxyl group or NR43R44and R43and R44are as defined in claim 1), or W4(where W4is such as defined in claim 1))), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

36. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10 alkylaminocarbonyl groups, C1-10alkylaminocarbonyl group, C1-10alkyl fluoride group, a C1-10forelcosure, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents selected from the group consisting of amino groups (amino groups substituted C1-10alkyl group, and C2-9heterocyclic group or a C2-14aryl group (C2-9heterocyclic group, and C2-14aryl group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, ka is boxylic groups, of nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), amino groups, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl groups, C1-10alkylsulfonyl groups, sulfanilic groups, sulfinyl groups and tylnej groups (amino, mono - or di-C1-10alkylamino, C1-10alkoxygroup, C1-10thioalkyl group, C1-10alkylsulfonyl group, sulfonylurea group, sulfinyl group and tirinya group optionally substituted by one or more C2-9heterocyclic groups or one or more C2-14aryl groups (C2-9heterocyclic group, and C2-14aryl group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl group is, of nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

37. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxyl the PAP may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C 2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2alkyline group, C1-10alkylsulphonyl is syrupy, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10 acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkali is boilershop, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

38. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24, R 25)n(where each of R24and R25independently represent a hydrogen atom, hydroxyl group, amino group, C1-6alkyl group or a C1-6alkoxygroup (C1-6alkyl group, and C1-6alkoxygroup can be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represent a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl what's groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more atoms, g is of Loginov), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

39. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkyl fluoride groups, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom or a C1-6alkyl group, (C16 the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10al is ylcarbonyl group optionally can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminor is PP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

40. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represent a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), the atom color is Yes, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic is nogroup, amino, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic is the SCP, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6 alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group substituted od is Oh or multiple C 2-9heterocyclic groups (C2-9heterocyclic groups may be substituted by one or more substituents selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or is it or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

41. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more Vice is s, independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group is a and C 1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10al is oxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino is the Rupp, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group substituted by one or more C2-9heterocyclic groups (C2-9heterocyclic groups may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino, mono or di (C 1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

42. Connection PP), 29) or 30), the cat is where R 3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3alkyl group mo is et to be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32p is ecstasy an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14aryloxy may be substituted by one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from g is uppy, consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype the long the flax can be substituted by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

43. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W 1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitrogen is PP, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline g is uppy, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, atoms ha is Oganov, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, atoms halog the new, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, Csub> 2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

44. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, and the om sulfur or NR 36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30in General, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of CA is boxylic groups, of nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl the x groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

45. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents selected from the group consisting of nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic, and one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one is m or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C 2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

46. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow g is the SCP, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group,C 2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C 1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl the groupings, and C 1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10and what of kilcarbery, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group substituted by one or more C2-9heterocyclic groups (C2-9heterocyclic group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group may not necessarily be zames who have one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminogroup is p, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

47. Connection PP) 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29isone hydrogen atom, hydroxyl group, a formyl group, a C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype the optional is tion can be substituted by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylsulphonyl is syrupy, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10 alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group substituted by one or more C2-9heterocyclic groups (C2-9heterocyclic groups may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10and kilcarbery group optionally can be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminogroup is p, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

48. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, a C 1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more atoms is halogen)), hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, Csub> 2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-0 alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one and the multiple halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

49. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25n is dependent represents a hydrogen atom or a C 1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10ALCO is dicarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted one linescale substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminor is PP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic and C1-10alkylaminocarbonyl group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, Aminov the SCP, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or formats whitesky acceptable salts of these compounds or their solvate.

50. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25)n(where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30 as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6Alki the implementing groups (C 1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

51. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents independently represented as W1(CW2W3)mW4(where W1represents (CR24R25) (where each of R24and R25independently represents a hydrogen atom or a C1-6alkyl group, (C1-6the alkyl group may be substituted by one or more halogen atoms), and n is 0, 1, 2 or 3), an oxygen atom, a sulfur atom or NR36(where R36represents a hydrogen atom, a C1-6alkyl group, formyl group or a C1-6alkylcarboxylic group), each of W2and W3independently represents a hydrogen atom or a C1-3alkyl group, (C1-3the alkyl group may be substituted by one or more halogen atoms), m is 0, 1, 2 or 3, and W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine GRU is dust, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, NIT is AGroup, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

52. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group substituted by-W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla g is the SCP, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, n is regroup, of cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10Alcock carbanilide group and C 1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10and what of kilcarbery, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine do not could the t to be substituted by one or more substituents, selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, aminogroup is p, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9heterocyclic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10al is icarbonate, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or supplied with the ski acceptable salts of these compounds or their solvate.

53. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is substituted by-W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29represents a hydrogen atom, hydroxyl group, formyl group, C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted for the one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl group or a C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and R30represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group, C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be zames who have one or more substituents, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms is in) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), C1-10alkyl group, a C2-6alkenylphenol group, C2-6alkylamino group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkylcarboxylic group (C1-10alkyl group, a C2-6Alchemilla group, C2-6Alchemilla group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, ka is bamaileh groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy the Rupp (C 2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy) and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfo, sulfamoyl groups and C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups, C2-9GE is eroticlick groups (C 1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10acylcarnitine group and C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10 alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

54. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by-W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3-G-(CH2)m4(where G is a CR31R32(where R31the present is the focus of a hydrogen atom, C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9GE is eroticline group may be substituted by one or more substituents, selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more atom of the mi by halogen or by one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfa is oilrich groups, of sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C-14 aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

55. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents independently represented as W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where R29and R30taken together, means -(CH2)m3/sub> -G-(CH2)m4(where G is a CR31R32(where R31represents a hydrogen atom, a C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup, C2-14alloctype (C1-10alkyl group, a C2-14aryl group, a C1-10alkoxygroup and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), a hydroxyl group or a protected hydroxyl group, and R32represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10 alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14 aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))) or NR33(where R33represents an amino group, mono - or di-C1-10alkylamino, C1-10alkylcarboxylic, C1-10alkylaminocarbonyl group or a C2-9heterocyclic group (mono - or di-C1-10alkylamino, C1-10alkylarene the amino group, C1-10alkylaminocarbonyl group and C2-9heterocyclic group may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, amino groups, hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can bytesneeded one or more C 1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), and each of m3 and m4 independently is an integer from 0 to 5, provided that m3+m4 is 3, 4 or 5))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

56. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, ginoli is inuu group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents independently represented as W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic g the SCP, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)))))); tout the measures prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

57. Connection PP), 29) or 30), in which R3represents a phenyl group (the phenyl group is optionally substituted by one or more substituents independently represented as W4(where W4represents the SO2R28, SOR28or COR28(where R28represents NR29R30(where NR29R30as a whole, means a nitrogen-containing C2-9cyclic group (the nitrogen-containing C2-9a cyclic group optionally may be substituted by one or more hydrogen atoms and is substituted by two or three substituents, independently selected from the group consisting of hydroxyl groups, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group and C1-10acylcarnitine group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, nitro groups, cyano groups, at the MOU halogen, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, Csub> 2-14aryl groups, and C2-14aryloxy)))))); the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

58. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents, optionally selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, C1-10alkyl fluoride group, a C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups and C1-10alkylcarboxylic and one or more C1-6alkyl groups (C1-6alkyl group optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), one or more substituents, selected from the group sotoyama is from hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkylsulfonamides, C1-10thioalkyl groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms is in, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, Csub> 2-14aryl groups, and C2-14aryloxy)), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups and sulfo -)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

59. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more C1-6alkyl groups (C1-6alkyl group optionally substituted by one or more substituents selected from the group consisting of hydroxyl groups, amino groups, mono - or di-C1-10alkylamino and C1-6alkoxygroup (mono - or di-C1-10alkylamino and C1-6alkoxygroup can be substituted by one or more halogen atoms), and one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups and sulfo -)), tautomers, prodrugs or pharmaceutically acceptable Sol is indicated compounds or their solvate.

60. Connection PP), 29) or 30), in which R3represents a substituted C2-14aryl group (substituted C2-14aryl group optionally may be substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkylsulfonamides, C1-10thioalkyl groups (C1-10alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonyl is laminography and C 1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxy is PP, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

61. Connection PP), 29) or 30), in which R3is any of the following structures (these structures are optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, hydroxyl groups, amino groups, tylnej groups, nitro groups, cyano groups, halogen atoms, carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, formyl groups, C1-10alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl groups, C1-10alkylsulfonamides, C1-10thioalkyl groups (C1-10alkyl group, a C2-6alkene the global group, C2-6alkyline group, C1-10alkylcarboxylic, C1-10alkoxycarbonyl group, C1-10alkoxygroup, C1-10acylcarnitine group, C1-10alkylcarboxylic, mono - or di-C1-10alkylamino, C1-10alkylaminocarbonyl group, C1-10alkylaminocarbonyl group, C1-10alkylsulfonamides and C1-10thioalkyl group optionally can be substituted by one or more substituents selected from the group consisting of carboxyl groups, carbamoyl groups, sulfamoyl groups, sulfo, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14alloctype can be substituted by one or more C1-6alkyl groups (C1-6alkyl groups can be substituted by one or more halogen atoms) or one or more halogen atoms)), C2-14aryl groups, and C2-14aryloxy (C2-14aryl group, and C2-14anilox the groups optionally can be substituted by one or more substituents, selected from the group consisting of C1-10alkyl groups (C1-10alkyl groups can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkoxygroup, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy)), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

62. Connection PP), 29) or 30), in which R3represents a phenyl group, thienyl group, follow group, pyridazinyl group, pyridyloxy group, pinolillo group or izohinolinove group (phenyl group, thienyl group, furilla group, pyridazinyl group, Peregrina group, kinolinna group or izochinolina group optionally substituted by one or more substituents selected from the group consisting of hydrogen atoms, nitro groups, cyano groups, halogen atoms, amino groups, C1-10alkylaminocarbonyl groups, C1-10alkylaminocarbonyl g the SCP, C1-10alkyl fluoride group, a C1-10forelcosure, sulfamoyl groups, carbamoyl groups and C1-10alkylcarboxylic, and one or more substituents selected from the group consisting of C1-6alkyl groups, C2-6alkenyl groups, C2-6etkinlik groups, C1-10alkylcarboxylic groups, C1-10alkylthiomethyl groups and C1-10alkylsulfonyl groups (C1-6alkyl group, a C2-6alkeneamine group, C2-6alkyline group, C1-10acylcarnitine group, C1-10alkyldiethanolamine group and C1-10alkylsulfonyl group optionally substituted by one or more substituents selected from the group consisting of hydrogen, C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy is, and one or more substituents selected from C2-9heterocyclic groups (C2-9heterocyclic group optionally can be substituted by one or more substituents selected from the group consisting of C1-10alkyl groups, C1-10alkoxygroup (C1-10alkyl groups and C1-10alkoxygroup can be substituted by one or more halogen atoms), C2-6alkenyl groups, C2-6etkinlik groups, carboxyl groups, nitro groups, cyano groups, halogen atoms, C1-10alkylcarboxylic groups, C1-10alkylcarboxylic, C1-10alkoxycarbonyl groups, C1-10alkylcarboxylic, amino groups, mono - or di-C1-10alkylamino, hydroxyl groups, protected hydroxyl groups, C2-14aryl groups, and C2-14aryloxy))), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

63. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the following combinations shown in table 1, the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate. The symbols in table 1 denote the following substituents.

Table 1

-----what-----------------------------------------

No A B R1L1R2L2L3Y L4R3X

-----------------------------------------------

1 N NMe Q1a a bond Me bond NH S NH T3a OH

2 N NMe Q1a a bond Me bond NH S NH T3b OH

3 N NMe Q1a a bond Me bond NH S NH T3c OH

4 N NMe Q1a a bond Me bond NH S NH T3d OH

5 N NMe Q1a a bond Me bond NH S NH T3e OH

6 N NMe Q1a a bond Me bond NH S NH T3f OH

7 N NMe Q1a a bond Me bond NH S NH T3g OH

8 N NMe Q1a a bond Me bond NH S NH T3h OH

9 N NMe Q1a a bond Me bond NH S NH T3i OH

10 N NMe Q1a a bond Me bond NH S NH T3j OH

11 N NMe Q1a a bond Me bond NH S a bond T3a OH

12 N NMe Q1a a bond Me bond NH S a bond T3b OH

13 N NMe Q1a a bond Me bond NH S a bond T3c OH

14 N NMe Q1a a bond Me bond NH S a bond T3d OH

15 N NMe Q1a a bond Me bond NH S a bond T3e OH

16 N NMe Q1a a bond Me bond NH S a bond T3f OH

17 N NMe Q1a a bond Me bond NH S a bond T3g OH

18 N NMe Q1a a bond Me bond NH S a bond T3h OH

19 N NMe Q1a a bond Me bond NH S a bond T3i OH

20 N NMe Q1a a bond Me bond NH S a bond T3j OH

21 N NMe Q1a a bond Me bond NH O NH T3a OH

22 N NMe Q1a a bond Me bond NH O NH T3b OH

23 N NMe Q1a a bond Me bond NH O NH T3c OH

24 N NMe Q1a a bond Me bond NH O NH T3d OH

25 N NMe Q1a a bond Me bond NH O NH T3e OH

26 N NMe Q1a a bond Me bond NH O NH T3f OH

27 N NMe Q1a a bond Me bond NH O NH T3g OH

28 N NMe Q1a a bond Me bond NH O NH T3h OH

29 N NMe Q1a a bond Me bond NH O NH T3i OH

30 N NMe Q1a a bond Me bond NH O NH T3j OH

31 N NMe Q1a a bond Me bond NH O a bond T3a OH

32 N NMe Q1a a bond Me bond NH O a bond T3b OH

33 N NMe Q1a a bond Me bond NH O a bond T3c OH

34 N Ne Q1a a bond Me bond NH O a bond T3d OH

35 N NMe Q1a a bond Me bond NH O a bond T3e OH

36 N NMe Q1a a bond Me bond NH O a bond T3f OH

37 N NMe Q1a a bond Me bond NH O a bond T3g OH

38 N NMe Q1a a bond Me bond NH O a bond T3h OH

39 N NMe Q1a a bond Me bond NH O a bond T3i OH

40 N NMe Q1a a bond Me bond NH O a bond T3j OH

41 N NMe Q1a a bond H a bond NH S NH T3a OH

42 N NMe Q1a a bond H a bond NH S NH T3b OH

43 N NMe Q1a a bond H a bond NH S NH T3c OH

44 N NMe Q1a a bond H a bond NH S NH T3d OH

45 N NMe Q1a a bond H a bond NH S NH T3e OH

46 N NMe Q1a a bond H a bond NH S NH T3f OH

47 N NMe Q1a a bond H a bond NH S NH T3g OH

48 N NMe Q1a a bond H a bond NH S NH T3h OH

49 N NMe Q1a a bond H a bond NH S NH T3i OH

50 N NMe Q1a a bond H a bond NH S NH T3j OH

51 N NMe Q1a a bond H a bond NH S a bond T3a OH

52 N NMe Q1a a bond H a bond NH S a bond T3b OH

53 N NMe Q1a a bond H a bond NH S a bond T3c OH

54 N NMe Q1a a bond H a bond NH S a bond T3d OH

55 N NMe Q1a a bond H a bond NH S a bond T3e OH

56 N NMe Q1a a bond H a bond NH S a bond T3f OH

57 N NMe Q1a a bond H a bond NH S a bond T3g OH

58 N NMe Q1a a bond H a bond NH S a bond T3h OH

59 N NMe Q1a a bond H a bond NH S a bond T3i OH

60 N NMe Q1a a bond H a bond NH S a bond T3j OH

61 N NMe Q1a a bond H a bond NH O NH T3a OH

62 N NMe Q1a a bond H a bond NH O NH T3b OH

63 N NMe Q1a a bond H a bond NH O NH T3c OH

64 N NMe Q1a a bond H a bond NH O NH T3d OH

65 N NMe Q1a a bond H a bond NH O NH T3e OH

66 N NMe Q1a a bond H a bond NH O NH T3f OH

67 N NMe Q1a a bond H a bond NH O NH T3g OH

68 N NMe Q1a a bond H a bond NH O NH T3h OH

69 N NMe Q1a a bond H a bond NH O NH T3i OH

70 N NMe Q1a a bond H a bond NH O NH T3j OH

71 N NMe Q1a a bond H a bond NH O a bond T3a OH

72 N NMe Q1a a bond H of light is e NH O a bond T3b OH

73 N NMe Q1a a bond H a bond NH O a bond T3c OH

74 N NMe Q1a a bond H a bond NH O a bond T3d OH

75 N NMe Q1a a bond H a bond NH O a bond T3e OH

76 N NMe Q1a a bond H a bond NH O a bond T3f OH

77 N NMe Q1a a bond H a bond NH O a bond T3g OH

78 N NMe Q1a a bond H a bond NH O a bond T3h OH

79 N NMe Q1a a bond H a bond NH O a bond T3i OH

80 N NMe Q1a a bond H a bond NH O a bond T3j OH

81 N NMe Q1b a bond Me bond NH S NH T3a OH

82 N NMe Q1b a bond Me bond NH S NH T3b OH

83 N NMe Q1b a bond Me bond NH S NH T3c OH

84 N NMe Q1b a bond Me bond NH S NH T3d OH

85 N NMe Q1b a bond Me bond NH S NH T3e OH

86 N NMe Q1b a bond Me bond NH S NH T3f OH

87 N NMe Q1b a bond Me bond NH S NH T3g OH

88 N NMe Q1b a bond Me bond NH S NH T3h OH

89 N NMe Q1b a bond Me bond NH S NH T3i OH

90 N NMe Q1b a bond Me bond NH S NH T3j OH

91 N NMe Q1b a bond Me bond NH S a bond T3a OH

92 N NMe Q1b a bond Me bond NH S a bond T3b OH

93 N NMe Q1b a bond Me bond NH S a bond T3c OH

94 N NMe Q1b a bond Me bond NH S a bond T3d OH

95 N NMe Q1b a bond Me bond NH S a bond T3e OH

96 N NMe Q1b a bond Me bond NH S a bond T3f OH

97 N NMe Q1b a bond Me bond NH S a bond T3g OH

98 N NMe Q1b a bond Me bond NH S a bond T3h OH

99 N NMe Q1b a bond Me bond NH S a bond T3i OH

100 N NMe Q1b a bond Me bond NH S a bond T3j OH

101 N NMe Q1b a bond Me bond NH O NH T3a OH

102 N NMe Q1b a bond Me bond NH O NH T3b OH

103 N NMe Q1b a bond Me bond NH O NH T3c OH

104 N NMe Q1b a bond Me bond NH O NH T3d OH

105 N NMe Q1b a bond Me bond NH O NH T3e OH

106 N NMe Q1b a bond Me bond NH O NH T3f OH

107 N NMe Q1b a bond Me bond NH O NH T3g OH

108 N NMe Q1b a bond Me bond NH O NH T3h OH

109 N NMe Q1b a bond Me bond NH O NH T3i OH

110 N NMe Q1b a bond Me bond NH O NH T3j OH

111 N NMe Q1b a bond Me bond NH O a bond T3a OH

112 N NMe Q1b a bond Me bond NH O a bond T3b OH

113 N NMe Q1b a bond Me bond NH O a bond T3c OH

114 N NMe Q1b a bond Me bond NH O a bond T3d OH

115 N NMe Q1b a bond Me bond NH O a bond T3e OH

116 N NMe Q1b a bond Me bond NH O a bond T3f OH

117 N NMe Q1b a bond Me bond NH O a bond T3g OH

118 N NMe Q1b a bond Me bond NH O a bond T3h OH

119 N NMe Q1b a bond Me bond NH O a bond T3i OH

120 N NMe Q1b a bond Me bond NH O a bond T3j OH

121 N NMe Q1b a bond H a bond NH S NH T3a OH

122 N NMe Q1b a bond H a bond NH S NH T3b OH

123 N NMe Q1b a bond H a bond NH S NH T3c OH

124 N NMe Q1b a bond H a bond NH S NH T3d OH

125 N NMe Q1b a bond H a bond NH S NH T3e OH

126 N NMe Q1b a bond H a bond NH S NH T3f OH

127 N NMe Q1b a bond H a bond NH S NH T3g OH

128 N NMe Q1b a bond H a bond NH S NH T3h OH

129 N NMe Q1b a bond H a bond NH S NH T3i OH

130 N NMe Q1b a bond H a bond NH S NH T3j OH

131 N NMe Q1b a bond H a bond NH S a bond T3a OH

132 N NMe Q1b a bond H a bond NH S a bond T3b OH

133 N NMe Q1b a bond H a bond NH S a bond T3c OH

134 N NMe Q1b a bond H a bond NH S a bond T3d OH

135 N NMe Q1b a bond H a bond NH S a bond T3e OH

136 N NMe Q1b a bond H a bond NH S a bond T3f OH

137 N NMe Q1b a bond H a bond NH S a bond T3g OH

138 N NMe Q1b a bond H a bond NH S a bond T3h OH

139 N NMe Q1b a bond H a bond NH S a bond T3i OH

140 N NMe Q1b a bond H a bond NH S a bond T3j OH

141 N NMe Q1b a bond H a bond NH O NH T3a OH

142 N NMe Q1b a bond H a bond NH O NH T3b OH

143 N NMe Q1b a bond H a bond NH O NH T3c OH

144 N NMe Q1b a bond H a bond NH O NH T3d OH

145 N NMe Q1b a bond H a bond NH O NH T3e OH

146 N NMe Q1b a bond H with the IDE NH O NH T3f OH

147 N NMe Q1b a bond H a bond NH O NH T3g OH

148 N NMe Q1b a bond H a bond NH O NH T3h OH

149 N NMe Q1b a bond H a bond NH O NH T3i OH

150 N NMe Q1b a bond H a bond NH O NH T3j OH

151 N NMe Q1b a bond H a bond NH O a bond T3a OH

152 N NMe Q1b a bond H a bond NH O a bond T3b OH

153 N NMe Q1b a bond H a bond NH O a bond T3c OH

154 N NMe Q1b a bond H a bond NH O a bond T3d OH

155 N NMe Q1b a bond H a bond NH O a bond T3e OH

156 N NMe Q1b a bond H a bond NH O a bond T3f OH

157 N NMe Q1b a bond H a bond NH O a bond T3g OH

158 N NMe Q1b a bond H a bond NH O a bond T3h OH

159 N NMe Q1b a bond H a bond NH O a bond T3i OH

160 N NMe Q1b a bond H a bond NH O a bond T3j OH

161 N NMe Q1c a bond Me bond NH S NH T3a OH

162 N NMe Q1c a bond Me bond NH S NH T3b OH

163 N NMe Q1c a bond Me bond NH S NH T3c OH

164 N NMe Q1c a bond Me bond NH S NH T3d OH

165 N NMe Q1c a bond Me bond NH S NH T3e OH

166 N NMe Q1c a bond Me bond NH S NH T3f OH

167 N NMe Q1c a bond Me bond NH S NH T3g OH

168 N NMe Q1c a bond Me bond NH S NH T3h OH

169 N NMe Q1c a bond Me bond NH S NH T3i OH

170 N NMe Q1c a bond Me bond NH S NH T3j OH

171 N NMe Q1c a bond Me bond NH S a bond T3a OH

172 N NMe Q1c a bond Me bond NH S a bond T3b OH

173 N NMe Q1c a bond Me bond NH S a bond T3c OH

174 N NMe Q1c a bond Me bond NH S a bond T3d OH

175 N NMe Q1c a bond Me bond NH S a bond T3e OH

176 N NMe Q1c a bond Me bond NH S a bond T3f OH

177 N NMe Q1c a bond Me bond NH S a bond T3g OH

178 N NMe Q1c a bond Me bond NH S a bond T3h OH

179 N NMe Q1c a bond Me bond NH S a bond T3i OH

180 N NMe Q1c a bond Me bond NH S a bond T3j OH

181 N NMe Q1c a bond Me bond NH O NH T3a OH

182 N NMe Q1c a bond Me bond NH O NH T3b OH

183 N NMe Q1c with the IDE Me bond NH O NH T3c OH

184 N NMe Q1c a bond Me bond NH O NH T3d OH

185 N NMe Q1c a bond Me bond NH O NH T3e OH

186 N NMe Q1c a bond Me bond NH O NH T3f OH

187 N NMe Q1c a bond Me bond NH O NH T3g OH

188 N NMe Q1c a bond Me bond NH O NH T3h OH

189 N NMe Q1c a bond Me bond NH O NH T3i OH

190 N NMe Q1c a bond Me bond NH O NH T3j OH

191 N NMe Q1c a bond Me bond NH O a bond T3a OH

192 N NMe Q1c a bond Me bond NH O a bond T3b OH

193 N NMe Q1c a bond Me bond NH O a bond T3c OH

194 N NMe Q1c a bond Me bond NH O a bond T3d OH

195 N NMe Q1c a bond Me bond NH O a bond T3e OH

196 N NMe Q1c a bond Me bond NH O a bond T3f OH

197 N NMe Q1c a bond Me bond NH O a bond T3g OH

198 N NMe Q1c a bond Me bond NH O a bond T3h OH

199 N NMe Q1c a bond Me bond NH O a bond T3i OH

200 N NMe Q1c a bond Me bond NH O a bond T3j OH

201 N NMe Q1c a bond H a bond NH S NH T3a OH

202 N NMe Q1c a bond H a bond NH S NH T3b OH

203 N NMe Q1c a bond H a bond NH S NH T3c OH

204 N NMe Q1c a bond H a bond NH S NH T3d OH

205 N NMe Q1c a bond H a bond NH S NH T3e OH

206 N NMe Q1c a bond H a bond NH S NH T3f OH

207 N NMe Q1c a bond H a bond NH S NH T3g OH

208 N NMe Q1c a bond H a bond NH S NH T3h OH

209 N NMe Q1c a bond H a bond NH S NH T3i OH

210 N NMe Q1c a bond H a bond NH S NH T3j OH

211 N NMe Q1c a bond H a bond NH S a bond T3a OH

212 N NMe Q1c a bond H a bond NH S a bond T3b OH

213 N NMe Q1c a bond H a bond NH S a bond T3c OH

214 N NMe Q1c a bond H a bond NH S a bond T3d OH

215 N NMe Q1c a bond H a bond NH S a bond T3e OH

216 N NMe Q1c a bond H a bond NH S a bond T3f OH

217 N NMe Q1c a bond H a bond NH S a bond T3g OH

218 N NMe Q1c a bond H a bond NH S a bond T3h OH

219 N NMe Q1c a bond H a bond NH S a bond T3i OH

220 N NMe Q1c a bond H with the IDE NH S a bond T3j OH

221 N NMe Q1c a bond H a bond NH O NH T3a OH

222 N NMe Q1c a bond H a bond NH O NH T3b OH

223 N NMe Q1c a bond H a bond NH O NH T3c OH

224 N NMe Q1c a bond H a bond NH O NH T3d OH

225 N NMe Q1c a bond H a bond NH O NH T3e OH

226 N NMe Q1c a bond H a bond NH O NH T3f OH

227 N NMe Q1c a bond H a bond NH O NH T3g OH

228 N NMe Q1c a bond H a bond NH O NH T3h OH

229 N NMe Q1c a bond H a bond NH O NH T3i OH

230 N NMe Q1c a bond H a bond NH O NH T3j OH

231 N NMe Q1c a bond H a bond NH O a bond T3a OH

232 N NMe Q1c a bond H a bond NH O a bond T3b OH

233 N NMe Q1c a bond H a bond NH O a bond T3c OH

234 N NMe Q1c a bond H a bond NH O a bond T3d OH

235 N NMe Q1c a bond H a bond NH O a bond T3e OH

236 N NMe Q1c a bond H a bond NH O a bond T3f OH

237 N NMe Q1c a bond H a bond NH O a bond T3g OH

238 N NMe Q1c a bond H a bond NH O a bond T3h OH

239 N NMe Q1c a bond H a bond NH O a bond T3i OH

240 N NMe Q1c a bond H a bond NH O a bond T3j OH

241 N NMe Q1i a bond Me bond NH S NH T3a OH

242 N NMe Q1i a bond Me bond NH S NH T3b OH

243 N NMe Q1i a bond Me bond NH S NH T3c OH

244 N NMe Q1i a bond Me bond NH S NH T3d OH

245 N NMe Q1i a bond Me bond NH S NH T3e OH

246 N NMe Q1i a bond Me bond NH S NH T3f OH

247 N NMe Q1i a bond Me bond NH S NH T3g OH

248 N NMe Q1i a bond Me bond NH S NH T3h OH

249 N NMe Q1i a bond Me bond NH S NH T3i OH

250 N NMe Q1i a bond Me bond NH S NH T3j OH

251 N NMe Q1i a bond Me bond NH S a bond T3a OH

252 N NMe Q1i a bond Me bond NH S a bond T3b OH

253 N NMe Q1i a bond Me bond NH S a bond T3c OH

254 N NMe Q1i a bond Me bond NH S a bond T3d OH

255 N NMe Q1i a bond Me bond NH S a bond T3e OH

256 N NMe Q1i a bond Me bond NH S a bond T3f OH

257 N NMe Q1i a bond Me bond NH S a bond 3g OH

258 N NMe Q1i a bond Me bond NH S a bond T3h OH

259 N NMe Q1i a bond Me bond NH S a bond T3i OH

260 N NMe Q1i a bond Me bond NH S a bond T3j OH

261 N NMe Q1i a bond Me bond NH O NH T3a OH

262 N NMe Q1i a bond Me bond NH O NH T3b OH

263 N NMe Q1i a bond Me bond NH O NH T3c OH

264 N NMe Q1i a bond Me bond NH O NH T3d OH

265 N NMe Q1i a bond Me bond NH O NH T3e OH

266 N NMe Q1i a bond Me bond NH O NH T3f OH

267 N NMe Q1i a bond Me bond NH O NH T3g OH

268 N NMe Q1i a bond Me bond NH O NH T3h OH

269 N NMe Q1i a bond Me bond NH O NH T3i OH

270 N NMe Q1i a bond Me bond NH O NH T3j OH

271 N NMe Q1i a bond Me bond NH O a bond T3a OH

272 N NMe Q1i a bond Me bond NH O a bond T3b OH

273 N NMe Q1i a bond Me bond NH O a bond T3c OH

274 N NMe Q1i a bond Me bond NH O a bond T3d OH

275 N NMe Q1i a bond Me bond NH O a bond T3e OH

276 N NMe Q1i a bond Me bond NH O a bond T3f OH

277 N NMe Q1i a bond Me bond NH O a bond T3g OH

278 N NMe Q1i a bond Me bond NH O a bond T3h OH

279 N NMe Q1i a bond Me bond NH O a bond T3i OH

280 N NMe Q1i a bond Me bond NH O a bond T3j OH

281 N NMe Q1i a bond H a bond NH S NH T3a OH

282 N NMe Q1i a bond H a bond NH S NH T3b OH

283 N NMe Q1i a bond H a bond NH S NH T3c OH

284 N NMe Q1i a bond H a bond NH S NH T3d OH

285 N NMe Q1i a bond H a bond NH S NH T3e OH

286 N NMe Q1i a bond H a bond NH S NH T3f OH

287 N NMe Q1i a bond H a bond NH S NH T3g OH

288 N NMe Q1i a bond H a bond NH S NH T3h OH

289 N NMe Q1i a bond H a bond NH S NH T3i OH

290 N NMe Q1i a bond H a bond NH S NH T3j OH

291 N NMe Q1i a bond H a bond NH S a bond T3a OH

292 N NMe Q1i a bond H a bond NH S a bond T3b OH

293 N NMe Q1i a bond H a bond NH S a bond T3c OH

294 N NMe Q1i a bond H a bond NH S St the z T3d OH

295 N NMe Q1i a bond H a bond NH S a bond T3e OH

296 N NMe Q1i a bond H a bond NH S a bond T3f OH

297 N NMe Q1i a bond H a bond NH S a bond T3g OH

298 N NMe Q1i a bond H a bond NH S a bond T3h OH

299 N NMe Q1i a bond H a bond NH S a bond T3i OH

300 N NMe Q1i a bond H a bond NH S a bond T3j OH

301 N NMe Q1i a bond H a bond NH O NH T3a OH

302 N NMe Q1i a bond H a bond NH O NH T3b OH

303 N NMe Q1i a bond H a bond NH O NH T3c OH

304 N NMe Q1i a bond H a bond NH O NH T3d OH

305 N NMe Q1i a bond H a bond NH O NH T3e OH

306 N NMe Q1i a bond H a bond NH O NH T3f OH

307 N NMe Q1i a bond H a bond NH O NH T3g OH

308 N NMe Q1i a bond H a bond NH O NH T3h OH

309 N NMe Q1i a bond H a bond NH O NH T3i OH

310 N NMe Q1i a bond H a bond NH O NH T3j OH

311 N NMe Q1i a bond H a bond NH O a bond T3a OH

312 N NMe Q1i a bond H a bond NH O a bond T3b OH

313 N NMe Q1i a bond H a bond NH O a bond T3c OH

314 N NMe Q1i a bond H a bond NH O a bond T3d OH

315 N NMe Q1i a bond H a bond NH O a bond T3e OH

316 N NMe Q1i a bond H a bond NH O a bond T3f OH

317 N NMe Q1i a bond H a bond NH O a bond T3g OH

318 N NMe Q1i a bond H a bond NH O a bond T3h OH

319 N NMe Q1i a bond H a bond NH O a bond T3i OH

320 N NMe Q1i a bond H a bond NH O a bond T3j OH

321 N NMe Q1j a bond Me bond NH S NH T3a OH

322 N NMe Q1j a bond Me bond NH S NH T3b OH

323 N NMe Q1j a bond Me bond NH S NH T3c OH

324 N NMe Q1j a bond Me bond NH S NH T3d OH

325 N NMe Q1j a bond Me bond NH S NH T3e OH

326 N NMe Q1j a bond Me bond NH S NH T3f OH

327 N NMe Q1j a bond Me bond NH S NH T3g OH

328 N NMe Q1j a bond Me bond NH S NH T3h OH

329 N NMe Q1j a bond Me bond NH S NH T3i OH

330 N NMe Q1j a bond Me bond NH S NH T3j OH

331 N NMe Q1j a bond Me bond NH S a bond T3a OH/p>

332 N NMe Q1j a bond Me bond NH S a bond T3b OH

333 N NMe Q1j a bond Me bond NH S a bond T3c OH

334 N NMe Q1j a bond Me bond NH S a bond T3d OH

335 N NMe Q1j a bond Me bond NH S a bond T3e OH

336 N NMe Q1j a bond Me bond NH S a bond T3f OH

337 N NMe Q1j a bond Me bond NH S a bond T3g OH

338 N NMe Q1j a bond Me bond NH S a bond T3h OH

339 N NMe Q1j a bond Me bond NH S a bond T3i OH

340 N NMe Q1j a bond Me bond NH S a bond T3j OH

341 N NMe Q1j a bond Me bond NH O NH T3a OH

342 N NMe Q1j a bond Me bond NH O NH T3b OH

343 N NMe Q1j a bond Me bond NH O NH T3c OH

344 N NMe Q1j a bond Me bond NH O NH T3d OH

345 N NMe Q1j a bond Me bond NH O NH T3e OH

346 N NMe Q1j a bond Me bond NH O NH T3f OH

347 N NMe Q1j a bond Me bond NH O NH T3g OH

348 N NMe Q1j a bond Me bond NH O NH T3h OH

349 N NMe Q1j a bond Me bond NH O NH T3i OH

350 N NMe Q1j a bond Me bond NH O NH T3j OH

351 N NMe Q1j a bond Me bond NH O a bond T3a OH

352 N NMe Q1j a bond Me bond NH O a bond T3b OH

353 N NMe Q1j a bond Me bond NH O a bond T3c OH

354 N NMe Q1j a bond Me bond NH O a bond T3d OH

355 N NMe Q1j a bond Me bond NH O a bond T3e OH

356 N NMe Q1j a bond Me bond NH O a bond T3f OH

357 N NMe Q1j a bond Me bond NH O a bond T3g OH

358 N NMe Q1j a bond Me bond NH O a bond T3h OH

359 N NMe Q1j a bond Me bond NH O a bond T3i OH

360 N NMe Q1j a bond Me bond NH O a bond T3j OH

361 N NMe Q1j a bond H a bond NH S NH T3a OH

362 N NMe Q1j a bond H a bond NH S NH T3b OH

363 N NMe Q1j a bond H a bond NH S NH T3c OH

364 N NMe Q1j a bond H a bond NH S NH T3d OH

365 N NMe Q1j a bond H a bond NH S NH T3e OH

366 N NMe Q1j a bond H a bond NH S NH T3f OH

367 N NMe Q1j a bond H a bond NH S NH T3g OH

368 N NMe Q1j St is z H a bond NH S NH T3h OH

369 N NMe Q1j a bond H a bond NH S NH T3i OH

370 N NMe Q1j a bond H a bond NH S NH T3j OH

371 N NMe Q1j a bond H a bond NH S a bond T3a OH

372 N NMe Q1j a bond H a bond NH S a bond T3b OH

373 N NMe Q1j a bond H a bond NH S a bond T3c OH

374 N NMe Q1j a bond H a bond NH S a bond T3d OH

375 N NMe Q1j a bond H a bond NH S a bond T3e OH

376 N NMe Q1j a bond H a bond NH S a bond T3f OH

377 N NMe Q1j a bond H a bond NH S a bond T3g OH

378 N NMe Q1j a bond H a bond NH S a bond T3h OH

379 N NMe Q1j a bond H a bond NH S a bond T3i OH

380 N NMe Q1j a bond H a bond NH S a bond T3j OH

381 N NMe Q1j a bond H a bond NH O NH T3a OH

382 N NMe Q1j a bond H a bond NH O NH T3b OH

383 N NMe Q1j a bond H a bond NH O NH T3c OH

384 N NMe Q1j a bond H a bond NH O NH T3d OH

385 N NMe Q1j a bond H a bond NH O NH T3e OH

386 N NMe Q1j a bond H a bond NH O NH T3f OH

387 N NMe Q1j a bond H a bond NH O NH T3g OH

388 N NMe Q1j a bond H a bond NH O NH T3h OH

389 N NMe Q1j a bond H a bond NH O NH T3i OH

390 N NMe Q1j a bond H a bond NH O NH T3j OH

391 N NMe Q1j a bond H a bond NH O a bond T3a OH

392 N NMe Q1j a bond H a bond NH O a bond T3b OH

393 N NMe Q1j a bond H a bond NH O a bond T3c OH

394 N NMe Q1j a bond H a bond NH O a bond T3d OH

395 N NMe Q1j a bond H a bond NH O a bond T3e OH

396 N NMe Q1j a bond H a bond NH O a bond T3f OH

397 N NMe Q1j a bond H a bond NH O a bond T3g OH

398 N NMe Q1j a bond H a bond NH O a bond T3h OH

399 N NMe Q1j a bond H a bond NH O a bond T3i OH

400 N NMe Q1j a bond H a bond NH O a bond T3j OH

401 N S Q1a a bond Me bond NH S NH T3a OH

402 N S Q1a a bond Me bond NH S NH T3b OH

403 N S Q1a a bond Me bond NH S NH T3c OH

404 N S Q1a a bond Me bond NH S NH T3d OH

405 N S Q1a a bond Me bond NH S N T3e OH

406 N S Q1a a bond Me bond NH S NH T3f OH

407 N S Q1a a bond Me bond NH S NH T3g OH

408 N S Q1a a bond Me bond NH S NH T3h OH

409 N S Q1a a bond Me bond NH S NH T3i OH

410 N S Q1a a bond Me bond NH S NH T3j OH

411 N S Q1a a bond Me bond NH S a bond T3a OH

412 N S Q1a a bond Me bond NH S a bond T3b OH

413 N S Q1a a bond Me bond NH S a bond T3c OH

414 N S Q1a a bond Me bond NH S a bond T3d OH

415 N S Q1a a bond Me bond NH S a bond T3e OH

416 N S Q1a a bond Me bond NH S a bond T3f OH

417 N S Q1a a bond Me bond NH S a bond T3g OH

418 N S Q1a a bond Me bond NH S a bond T3h OH

419 N S Q1a a bond Me bond NH S a bond T3i OH

420 N S Q1a a bond Me bond NH S a bond T3j OH

421 N S Q1a a bond Me bond NH O NH T3a OH

422 N S Q1a a bond Me bond NH O NH T3b OH

423 N S Q1a a bond Me bond NH O NH T3c OH

424 N S Q1a a bond Me bond NH O NH T3d OH

425 N S Q1a a bond Me bond NH O NH T3e OH

426 N S Q1a a bond Me bond NH O NH T3f OH

427 N S Q1a a bond Me bond NH O NH T3g OH

428 N S Q1a a bond Me bond NH O NH T3h OH

429 N S Q1a a bond Me bond NH O NH T3i OH

430 N S Q1a a bond Me bond NH O NH T3j OH

431 N S Q1a a bond Me bond NH O a bond T3a OH

432 N S Q1a a bond Me bond NH O a bond T3b OH

433 N S Q1a a bond Me bond NH O a bond T3c OH

434 N S Q1a a bond Me bond NH O a bond T3d OH

435 N S Q1a a bond Me bond NH O a bond T3e OH

436 N S Q1a a bond Me bond NH O a bond T3f OH

437 N S Q1a a bond Me bond NH O a bond T3g OH

438 N S Q1a a bond Me bond NH O a bond T3h OH

439 N S Q1a a bond Me bond NH O a bond T3i OH

440 N S Q1a a bond Me bond NH O a bond T3j OH

441 N S Q1a a bond H a bond NH S NH T3a OH

442 N S Q1a a bond H a bond NH S NH T3b OH

443 N S Q1a St is z H a bond NH S NH T3c OH

444 N S Q1a a bond H a bond NH S NH T3d OH

445 N S Q1a a bond H a bond NH S NH T3e OH

446 N S Q1a a bond H a bond NH S NH T3f OH

447 N S Q1a a bond H a bond NH S NH T3g OH

448 N S Q1a a bond H a bond NH S NH T3h OH

449 N S Q1a a bond H a bond NH S NH T3i OH

450 N S Q1a a bond H a bond NH S NH T3j OH

451 N S Q1a a bond H a bond NH S a bond T3a OH

452 N S Q1a a bond H a bond NH S a bond T3b OH

453 N S Q1a a bond H a bond NH S a bond T3c OH

454 N S Q1a a bond H a bond NH S a bond T3d OH

455 N S Q1a a bond H a bond NH S a bond T3e OH

456 N S Q1a a bond H a bond NH S a bond T3f OH

457 N S Q1a a bond H a bond NH S a bond T3g OH

458 N S Q1a a bond H a bond NH S a bond T3h OH

459 N S Q1a a bond H a bond NH S a bond T3i OH

460 N S Q1a a bond H a bond NH S a bond T3j OH

461 N S Q1a a bond H a bond NH O NH T3a OH

462 N S Q1a a bond H a bond NH O NH T3b OH

463 N S Q1a a bond H a bond NH O NH T3c OH

464 N S Q1a a bond H a bond NH O NH T3d OH

465 N S Q1a a bond H a bond NH O NH T3e OH

466 N S Q1a a bond H a bond NH O NH T3f OH

467 N S Q1a a bond H a bond NH O NH T3g OH

468 N S Q1a a bond H a bond NH O NH T3h OH

469 N S Q1a a bond H a bond NH O NH T3i OH

470 N S Q1a a bond H a bond NH O NH T3j OH

471 N S Q1a a bond H a bond NH O a bond T3a OH

472 N S Q1a a bond H a bond NH O a bond T3b OH

473 N S Q1a a bond H a bond NH O a bond T3c OH

474 N S Q1a a bond H a bond NH O a bond T3d OH

475 N S Q1a a bond H a bond NH O a bond T3e OH

476 N S Q1a a bond H a bond NH O a bond T3f OH

477 N S Q1a a bond H a bond NH O a bond T3g OH

478 N S Q1a a bond H a bond NH O a bond T3h OH

479 N S Q1a a bond H a bond NH O a bond T3i OH

480 N S Q1a a bond H a bond NH O a bond T3j OH

481 N S Q1b a bond Me bond NH S NH T3a OH

482 N S Q1b a bond Me bond NH S NH T3b OH

483 N S Q1b a bond Me bond NH S NH T3c OH

484 N S Q1b a bond Me bond NH S NH T3d OH

485 N S Q1b a bond Me bond NH S NH T3e OH

486 N S Q1b a bond Me bond NH S NH T3f OH

487 N S Q1b a bond Me bond NH S NH T3g OH

488 N S Q1b a bond Me bond NH S NH T3h OH

489 N S Q1b a bond Me bond NH S NH T3i OH

490 N S Q1b a bond Me bond NH S NH T3j OH

491 N S Q1b a bond Me bond NH S a bond T3a OH

492 N S Q1b a bond Me bond NH S a bond T3b OH

493 N S Q1b a bond Me bond NH S a bond T3c OH

494 N S Q1b a bond Me bond NH S a bond T3d OH

495 N S Q1b a bond Me bond NH S a bond T3e OH

496 N S Q1b a bond Me bond NH S a bond T3f OH

497 N S Q1b a bond Me bond NH S a bond T3g OH

498 N S Q1b a bond Me bond NH S a bond T3h OH

499 N S Q1b a bond Me bond NH S a bond T3i OH

500 N S Q1b a bond Me bond NH S a bond T3j OH

501 N S Q1b a bond Me bond NH O NH T3a OH

502 N S Q1b a bond Me bond NH O NH T3b OH

503 N S Q1b a bond Me bond NH O NH T3c OH

504 N S Q1b a bond Me bond NH O NH T3d OH

505 N S Q1b a bond Me bond NH O NH T3e OH

506 N S Q1b a bond Me bond NH O NH T3f OH

507 N S Q1b a bond Me bond NH O NH T3g OH

508 N S Q1b a bond Me bond NH O NH T3h OH

509 N S Q1b a bond Me bond NH O NH T3i OH

510 N S Q1b a bond Me bond NH O NH T3j OH

511 N S Q1b a bond Me bond NH O a bond T3a OH

512 N S Q1b a bond Me bond NH O a bond T3b OH

513 N S Q1b a bond Me bond NH O a bond T3c OH

514 N S Q1b a bond Me bond NH O a bond T3d OH

515 N S Q1b a bond Me bond NH O a bond T3e OH

516 N S Q1b a bond Me bond NH O a bond T3f OH

517 N S Q1b a bond Me bond NH O a bond T3g OH

518 N S Q1b a bond Me bond NH O a bond T3h OH

519 N S Q1b a bond Me link to the e NH O a bond T3i OH

520 N S Q1b a bond Me bond NH O a bond T3j OH

521 N S Q1b a bond H a bond NH S NH T3a OH

522 N S Q1b a bond H a bond NH S NH T3b OH

523 N S Q1b a bond H a bond NH S NH T3c OH

524 N S Q1b a bond H a bond NH S NH T3d OH

525 N S Q1b a bond H a bond NH S NH T3e OH

526 N S Q1b a bond H a bond NH S NH T3f OH

527 N S Q1b a bond H a bond NH S NH T3g OH

528 N S Q1b a bond H a bond NH S NH T3h OH

529 N S Q1b a bond H a bond NH S NH T3i OH

530 N S Q1b a bond H a bond NH S NH T3j OH

531 N S Q1b a bond H a bond NH S a bond T3a OH

532 N S Q1b a bond H a bond NH S a bond T3b OH

533 N S Q1b a bond H a bond NH S a bond T3c OH

534 N S Q1b a bond H a bond NH S a bond T3d OH

535 N S Q1b a bond H a bond NH S a bond T3e OH

536 N S Q1b a bond H a bond NH S a bond T3f OH

537 N S Q1b a bond H a bond NH S a bond T3g OH

538 N S Q1b a bond H a bond NH S a bond T3h OH

539 N S Q1b a bond H a bond NH S a bond T3i OH

540 N S Q1b a bond H a bond NH S a bond T3j OH

541 N S Q1b a bond H a bond NH O NH T3a OH

542 N S Q1b a bond H a bond NH O NH T3b OH

543 N S Q1b a bond H a bond NH O NH T3c OH

544 N S Q1b a bond H a bond NH O NH T3d OH

545 N S Q1b a bond H a bond NH O NH T3e OH

546 N S Q1b a bond H a bond NH O NH T3f OH

547 N S Q1b a bond H a bond NH O NH T3g OH

548 N S Q1b a bond H a bond NH O NH T3h OH

549 N S Q1b a bond H a bond NH O NH T3i OH

550 N S Q1b a bond H a bond NH O NH T3j OH

551 N S Q1b a bond H a bond NH O a bond T3a OH

552 N S Q1b a bond H a bond NH O a bond T3b OH

553 N S Q1b a bond H a bond NH O a bond T3c OH

554 N S Q1b a bond H a bond NH O a bond T3d OH

555 N S Q1b a bond H a bond NH O a bond T3e OH

556 N S Q1b a bond H a bond NH O a bond T3f OH

557 N S Q1b a bond H a bond NH O a bond T3g OH

558 N S 1b bond H a bond NH O a bond T3h OH

559 N S Q1b a bond H a bond NH O a bond T3i OH

560 N S Q1b a bond H a bond NH O a bond T3j OH

561 N S Q1c a bond Me bond NH S NH T3a OH

562 N S Q1c a bond Me bond NH S NH T3b OH

563 N S Q1c a bond Me bond NH S NH T3c OH

564 N S Q1c a bond Me bond NH S NH T3d OH

565 N S Q1c a bond Me bond NH S NH T3e OH

566 N S Q1c a bond Me bond NH S NH T3f OH

567 N S Q1c a bond Me bond NH S NH T3g OH

568 N S Q1c a bond Me bond NH S NH T3h OH

569 N S Q1c a bond Me bond NH S NH T3i OH

570 N S Q1c a bond Me bond NH S NH T3j OH

571 N S Q1c a bond Me bond NH S a bond T3a OH

572 N S Q1c a bond Me bond NH S a bond T3b OH

573 N S Q1c a bond Me bond NH S a bond T3c OH

574 N S Q1c a bond Me bond NH S a bond T3d OH

575 N S Q1c a bond Me bond NH S a bond T3e OH

576 N S Q1c a bond Me bond NH S a bond T3f OH

577 N S Q1c a bond Me bond NH S a bond T3g OH

578 N S Q1c a bond Me bond NH S a bond T3h OH

579 N S Q1c a bond Me bond NH S a bond T3i OH

580 N S Q1c a bond Me bond NH S a bond T3j OH

581 N S Q1c a bond Me bond NH O NH T3a OH

582 N S Q1c a bond Me bond NH O NH T3b OH

583 N S Q1c a bond Me bond NH O NH T3c OH

584 N S Q1c a bond Me bond NH O NH T3d OH

585 N S Q1c a bond Me bond NH O NH T3e OH

586 N S Q1c a bond Me bond NH O NH T3f OH

587 N S Q1c a bond Me bond NH O NH T3g OH

588 N S Q1c a bond Me bond NH O NH T3h OH

589 N S Q1c a bond Me bond NH O NH T3i OH

590 N S Q1c a bond Me bond NH O NH T3j OH

591 N S Q1c a bond Me bond NH O a bond T3a OH

592 N S Q1c a bond Me bond NH O a bond T3b OH

593 N S Q1c a bond Me bond NH O a bond T3c OH

594 N S Q1c a bond Me bond NH O a bond T3d OH

595 N S Q1c a bond Me bond NH O a bond T3e OH

596 N S Q1c a bond Me the link NH Swazi T3f OH

597 N S Q1c a bond Me bond NH O a bond T3g OH

598 N S Q1c a bond Me bond NH O a bond T3h OH

599 N S Q1c a bond Me bond NH O a bond T3i OH

600 N S Q1c a bond Me bond NH O a bond T3j OH

601 N S Q1c a bond H a bond NH S NH T3a OH

602 N S Q1c a bond H a bond NH S NH T3b OH

603 N S Q1c a bond H a bond NH S NH T3c OH

604 N S Q1c a bond H a bond NH S NH T3d OH

605 N S Q1c a bond H a bond NH S NH T3e OH

606 N S Q1c a bond H a bond NH S NH T3f OH

607 N S Q1c a bond H a bond NH S NH T3g OH

608 N S Q1c a bond H a bond NH S NH T3h OH

609 N S Q1c a bond H a bond NH S NH T3i OH

610 N S Q1c a bond H a bond NH S NH T3j OH

611 N S Q1c a bond H a bond NH S a bond T3a OH

612 N S Q1c a bond H a bond NH S a bond T3b OH

613 N S Q1c a bond H a bond NH S a bond T3c OH

614 N S Q1c a bond H a bond NH S a bond T3d OH

615 N S Q1c a bond H a bond NH S a bond T3e OH

616 N S Q1c a bond H a bond NH S a bond T3f OH

617 N S Q1c a bond H a bond NH S a bond T3g OH

618 N S Q1c a bond H a bond NH S a bond T3h OH

619 N S Q1c a bond H a bond NH S a bond T3i OH

620 N S Q1c a bond H a bond NH S a bond T3j OH

621 N S Q1c a bond H a bond NH O NH T3a OH

622 N S Q1c a bond H a bond NH O NH T3b OH

623 N S Q1c a bond H a bond NH O NH T3c OH

624 N S Q1c a bond H a bond NH O NH T3d OH

625 N S Q1c a bond H a bond NH O NH T3e OH

626 N S Q1c a bond H a bond NH O NH T3f OH

627 N S Q1c a bond H a bond NH O NH T3g OH

628 N S Q1c a bond H a bond NH O NH T3h OH

629 N S Q1c a bond H a bond NH O NH T3i OH

630 N S Q1c a bond H a bond NH O NH T3j OH

631 N S Q1c a bond H a bond NH O a bond T3a OH

632 N S Q1c a bond H a bond NH O a bond T3b OH

633 N S Q1c a bond H a bond NH O a bond T3c OH

634 N S Q1c a bond H a bond NH O a bond T3d OH

635 NS Q1c a bond H a bond NH O a bond T3e OH

636 N S Q1c a bond H a bond NH O a bond T3f OH

637 N S Q1c a bond H a bond NH O a bond T3g OH

638 N S Q1c a bond H a bond NH O a bond T3h OH

639 N S Q1c a bond H a bond NH O a bond T3i OH

640 N S Q1c a bond H a bond NH O a bond T3j OH

641 N S Q1i a bond Me bond NH S NH T3a OH

642 N S Q1i a bond Me bond NH S NH T3b OH

643 N S Q1i a bond Me bond NH S NH T3c OH

644 N S Q1i a bond Me bond NH S NH T3d OH

645 N S Q1i a bond Me bond NH S NH T3e OH

646 N S Q1i a bond Me bond NH S NH T3f OH

647 N S Q1i a bond Me bond NH S NH T3g OH

648 N S Q1i a bond Me bond NH S NH T3h OH

649 N S Q1i a bond Me bond NH S NH T3i OH

650 N S Q1i a bond Me bond NH S NH T3j OH

651 N S Q1i a bond Me bond NH S a bond T3a OH

652 N S Q1i a bond Me bond NH S a bond T3b OH

653 N S Q1i a bond Me bond NH S a bond T3c OH

654 N S Q1i a bond Me bond NH S a bond T3d OH

655 N S Q1i a bond Me bond NH S a bond T3e OH

656 N S Q1i a bond Me bond NH S a bond T3f OH

657 N S Q1i a bond Me bond NH S a bond T3g OH

658 N S Q1i a bond Me bond NH S a bond T3h OH

659 N S Q1i a bond Me bond NH S a bond T3i OH

660 N S Q1i a bond Me bond NH S a bond T3j OH

661 N S Q1i a bond Me bond NH O NH T3a OH

662 N S Q1i a bond Me bond NH O NH T3b OH

663 N S Q1i a bond Me bond NH O NH T3c OH

664 N S Q1i a bond Me bond NH O NH T3d OH

665 N S Q1i a bond Me bond NH O NH T3e OH

666 N S Q1i a bond Me bond NH O NH T3f OH

667 N S Q1i a bond Me bond NH O NH T3g OH

668 N S Q1i a bond Me bond NH O NH T3h OH

669 N S Q1i a bond Me bond NH O NH T3i OH

670 N S Q1i a bond Me bond NH O NH T3j OH

671 N S Q1i a bond Me bond NH O a bond T3a OH

672 N S Q1i a bond Me bond NH O a bond T3b OH

673 N S Q1i a bond Me bond NH O with the IDE T3c OH

674 N S Q1i a bond Me bond NH O a bond T3d OH

675 N S Q1i a bond Me bond NH O a bond T3e OH

676 N S Q1i a bond Me bond NH O a bond T3f OH

677 N S Q1i a bond Me bond NH O a bond T3g OH

678 N S Q1i a bond Me bond NH O a bond T3h OH

679 N S Q1i a bond Me bond NH O a bond T3i OH

680 N S Q1i a bond Me bond NH O a bond T3j OH

681 N S Q1i a bond H a bond NH S NH T3a OH

682 N S Q1i a bond H a bond NH S NH T3b OH

683 N S Q1i a bond H a bond NH S NH T3c OH

684 N S Q1i a bond H a bond NH S NH T3d OH

685 N S Q1i a bond H a bond NH S NH T3e OH

686 N S Q1i a bond H a bond NH S NH T3f OH

687 N S Q1i a bond H a bond NH S NH T3g OH

688 N S Q1i a bond H a bond NH S NH T3h OH

689 N S Q1i a bond H a bond NH S NH T3i OH

690 N S Q1i a bond H a bond NH S NH T3j OH

691 N S Q1i a bond H a bond NH S a bond T3a OH

692 N S Q1i a bond H a bond NH S a bond T3b OH

693 N S Q1i a bond H a bond NH S a bond T3c OH

694 N S Q1i a bond H a bond NH S a bond T3d OH

695 N S Q1i a bond H a bond NH S a bond T3e OH

696 N S Q1i a bond H a bond NH S a bond T3f OH

697 N S Q1i a bond H a bond NH S a bond T3g OH

698 N S Q1i a bond H a bond NH S a bond T3h OH

699 N S Q1i a bond H a bond NH S a bond T3i OH

700 N S Q1i a bond H a bond NH S a bond T3j OH

701 N S Q1i a bond H a bond NH O NH T3a OH

702 N S Q1i a bond H a bond NH O NH T3b OH

703 N S Q1i a bond H a bond NH O NH T3c OH

704 N S Q1i a bond H a bond NH O NH T3d OH

705 N S Q1i a bond H a bond NH O NH T3e OH

706 N S Q1i a bond H a bond NH O NH T3f OH

707 N S Q1i a bond H a bond NH O NH T3g OH

708 N S Q1i a bond H a bond NH O NH T3h OH

709 N S Q1i a bond H a bond NH O NH T3i OH

710 N S Q1i a bond H a bond NH O NH T3j OH

711 N S Q1i a bond H a bond NH O a bond T3a OH

71 N S Q1i a bond H a bond NH O a bond T3b OH

713 N S Q1i a bond H a bond NH O a bond T3c OH

714 N S Q1i a bond H a bond NH O a bond T3d OH

715 N S Q1i a bond H a bond NH O a bond T3e OH

716 N S Q1i a bond H a bond NH O a bond T3f OH

717 N S Q1i a bond H a bond NH O a bond T3g OH

718 N S Q1i a bond H a bond NH O a bond T3h OH

719 N S Q1i a bond H a bond NH O a bond T3i OH

720 N S Q1i a bond H a bond NH O a bond T3j OH

721 N S Q1j a bond Me bond NH S NH T3a OH

722 N S Q1j a bond Me bond NH S NH T3b OH

723 N S Q1j a bond Me bond NH S NH T3c OH

724 N S Q1j a bond Me bond NH S NH T3d OH

725 N S Q1j a bond Me bond NH S NH T3e OH

726 N S Q1j a bond Me bond NH S NH T3f OH

727 N S Q1j a bond Me bond NH S NH T3g OH

728 N S Q1j a bond Me bond NH S NH T3h OH

729 N S Q1j a bond Me bond NH S NH T3i OH

730 N S Q1j a bond Me bond NH S NH T3j OH

731 N S Q1j a bond Me bond NH S a bond T3a OH

732 N S Q1j a bond Me bond NH S a bond T3b OH

733 N S Q1j a bond Me bond NH S a bond T3c OH

734 N S Q1j a bond Me bond NH S a bond T3d OH

735 N S Q1j a bond Me bond NH S a bond T3e OH

736 N S Q1j a bond Me bond NH S a bond T3f OH

737 N S Q1j a bond Me bond NH S a bond T3g OH

738 N S Q1j a bond Me bond NH S a bond T3h OH

739 N S Q1j a bond Me bond NH S a bond T3i OH

740 N S Q1j a bond Me bond NH S a bond T3j OH

741 N S Q1j a bond Me bond NH O NH T3a OH

742 N S Q1j a bond Me bond NH O NH T3b OH

743 N S Q1j a bond Me bond NH O NH T3c OH

744 N S Q1j a bond Me bond NH O NH T3d OH

745 N S Q1j a bond Me bond NH O NH T3e OH

746 N S Q1j a bond Me bond NH O NH T3f OH

747 N S Q1j a bond Me bond NH O NH T3g OH

748 N S Q1j a bond Me bond NH O NH T3h OH

749 N S Q1j a bond Me bond NH O NH T3i OH

750 N S Q1j a bond Me the link NHO NH T3j OH

751 N S Q1j a bond Me bond NH O a bond T3a OH

752 N S Q1j a bond Me bond NH O a bond T3b OH

753 N S Q1j a bond Me bond NH O a bond T3c OH

754 N S Q1j a bond Me bond NH O a bond T3d OH

755 N S Q1j a bond Me bond NH O a bond T3e OH

756 N S Q1j a bond Me bond NH O a bond T3f OH

757 N S Q1j a bond Me bond NH O a bond T3g OH

758 N S Q1j a bond Me bond NH O a bond T3h OH

759 N S Q1j a bond Me bond NH O a bond T3i OH

760 N S Q1j a bond Me bond NH O a bond T3j OH

761 N S Q1j a bond H a bond NH S NH T3a OH

762 N S Q1j a bond H a bond NH S NH T3b OH

763 N S Q1j a bond H a bond NH S NH T3c OH

764 N S Q1j a bond H a bond NH S NH T3d OH

765 N S Q1j a bond H a bond NH S NH T3e OH

766 N S Q1j a bond H a bond NH S NH T3f OH

767 N S Q1j a bond H a bond NH S NH T3g OH

768 N S Q1j a bond H a bond NH S NH T3h OH

769 N S Q1j a bond H a bond NH S NH T3i OH

770 N S Q1j a bond H a bond NH S NH T3j OH

771 N S Q1j a bond H a bond NH S a bond T3a OH

772 N S Q1j a bond H a bond NH S a bond T3b OH

773 N S Q1j a bond H a bond NH S a bond T3c OH

774 N S Q1j a bond H a bond NH S a bond T3d OH

775 N S Q1j a bond H a bond NH S a bond T3e OH

776 N S Q1j a bond H a bond NH S a bond T3f OH

777 N S Q1j a bond H a bond NH S a bond T3g OH

778 N S Q1j a bond H a bond NH S a bond T3h OH

779 N S Q1j a bond H a bond NH S a bond T3i OH

780 N S Q1j a bond H a bond NH S a bond T3j OH

781 N S Q1j a bond H a bond NH O NH T3a OH

782 N S Q1j a bond H a bond NH O NH T3b OH

783 N S Q1j a bond H a bond NH O NH T3c OH

784 N S Q1j a bond H a bond NH O NH T3d OH

785 N S Q1j a bond H a bond NH O NH T3e OH

786 N S Q1j a bond H a bond NH O NH T3f OH

787 N S Q1j a bond H a bond NH O NH T3g OH

788 N S Q1j a bond H a bond NH O N T3h OH

789 N S Q1j a bond H a bond NH O NH T3i OH

790 N S Q1j a bond H a bond NH O NH T3j OH

791 N S Q1j a bond H a bond NH O a bond T3a OH

792 N S Q1j a bond H a bond NH O a bond T3b OH

793 N S Q1j a bond H a bond NH O a bond T3c OH

794 N S Q1j a bond H a bond NH O a bond T3d OH

795 N S Q1j a bond H a bond NH O a bond T3e OH

796 N S Q1j a bond H a bond NH O a bond T3f OH

797 N S Q1j a bond H a bond NH O a bond T3g OH

798 N S Q1j a bond H a bond NH O a bond T3h OH

799 N S Q1j a bond H a bond NH O a bond T3i OH

800 N S Q1j a bond H a bond NH O a bond T3j OH

801 N O Q1a a bond Me bond NH S NH T3a OH

802 N O Q1a a bond Me bond NH S NH T3b OH

803 N O Q1a a bond Me bond NH S NH T3c OH

804 N O Q1a a bond Me bond NH S NH T3d OH

805 N O Q1a a bond Me bond NH S NH T3e OH

806 N O Q1a a bond Me bond NH S NH T3f OH

807 N O Q1a a bond Me bond NH S NH T3g OH

808 N O Q1a a bond Me bond NH S NH T3h OH

809 N O Q1a a bond Me bond NH S NH T3i OH

810 N O Q1a a bond Me bond NH S NH T3j OH

811 N O Q1a a bond Me bond NH S a bond T3a OH

812 N O Q1a a bond Me bond NH S a bond T3b OH

813 N O Q1a a bond Me bond NH S a bond T3c OH

814 N O Q1a a bond Me bond NH S a bond T3d OH

815 N O Q1a a bond Me bond NH S a bond T3e OH

816 N O Q1a a bond Me bond NH S a bond T3f OH

817 N O Q1a a bond Me bond NH S a bond T3g OH

818 N O Q1a a bond Me bond NH S a bond T3h OH

819 N O Q1a a bond Me bond NH S a bond T3i OH

820 N O Q1a a bond Me bond NH S a bond T3j OH

821 N O Q1a a bond Me bond NH O NH T3a OH

822 N O Q1a a bond Me bond NH O NH T3b OH

823 N O Q1a a bond Me bond NH O NH T3c OH

824 N O Q1a a bond Me bond NH O NH T3d OH

825 N O Q1a a bond Me bond NH O NH T3e OH

826 N O Q1a a bond Me the ligature NH O NH T3f OH

827 N O Q1a a bond Me bond NH O NH T3g OH

828 N O Q1a a bond Me bond NH O NH T3h OH

829 N O Q1a a bond Me bond NH O NH T3i OH

830 N O Q1a a bond Me bond NH O NH T3j OH

831 N O Q1a a bond Me bond NH O a bond T3a OH

832 N O Q1a a bond Me bond NH O a bond T3b OH

833 N O Q1a a bond Me bond NH O a bond T3c OH

834 N O Q1a a bond Me bond NH O a bond T3d OH

835 N O Q1a a bond Me bond NH O a bond T3e OH

836 N O Q1a a bond Me bond NH O a bond T3f OH

837 N O Q1a a bond Me bond NH O a bond T3g OH

838 N O Q1a a bond Me bond NH O a bond T3h OH

839 N O Q1a a bond Me bond NH O a bond T3i OH

840 N O Q1a a bond Me bond NH O a bond T3j OH

841 N O Q1a a bond H a bond NH S NH T3a OH

842 N O Q1a a bond H a bond NH S NH T3b OH

843 N O Q1a a bond H a bond NH S NH T3c OH

844 N O Q1a a bond H a bond NH S NH T3d OH

845 N O Q1a a bond H a bond NH S NH T3e OH

846 N O Q1a a bond H a bond NH S NH T3f OH

847 N O Q1a a bond H a bond NH S NH T3g OH

848 N O Q1a a bond H a bond NH S NH T3h OH

849 N O Q1a a bond H a bond NH S NH T3i OH

850 N O Q1a a bond H a bond NH S NH T3j OH

851 N O Q1a a bond H a bond NH S a bond T3a OH

852 N O Q1a a bond H a bond NH S a bond T3b OH

853 N O Q1a a bond H a bond NH S a bond T3c OH

854 N O Q1a a bond H a bond NH S a bond T3d OH

855 N O Q1a a bond H a bond NH S a bond T3e OH

856 N O Q1a a bond H a bond NH S a bond T3f OH

857 N O Q1a a bond H a bond NH S a bond T3g OH

858 N O Q1a a bond H a bond NH S a bond T3h OH

859 N O Q1a a bond H a bond NH S a bond T3i OH

860 N O Q1a a bond H a bond NH S a bond T3j OH

861 N O Q1a a bond H a bond NH O NH T3a OH

862 N O Q1a a bond H a bond NH O NH T3b OH

863 N O Q1a a bond H a bond NH O NH T3c OH

864 N O Q1a a bond H a bond NHO NH T3d OH

865 N O Q1a a bond H a bond NH O NH T3e OH

866 N O Q1a a bond H a bond NH O NH T3f OH

867 N O Q1a a bond H a bond NH O NH T3g OH

868 N O Q1a a bond H a bond NH O NH T3h OH

869 N O Q1a a bond H a bond NH O NH T3i OH

870 N O Q1a a bond H a bond NH O NH T3j OH

871 N O Q1a a bond H a bond NH O a bond T3a OH

872 N O Q1a a bond H a bond NH O a bond T3b OH

873 N O Q1a a bond H a bond NH O a bond T3c OH

874 N O Q1a a bond H a bond NH O a bond T3d OH

875 N O Q1a a bond H a bond NH O a bond T3e OH

876 N O Q1a a bond H a bond NH O a bond T3f OH

877 N O Q1a a bond H a bond NH O a bond T3g OH

878 N O Q1a a bond H a bond NH O a bond T3h OH

879 N O Q1a a bond H a bond NH O a bond T3i OH

880 N O Q1a a bond H a bond NH O a bond T3j OH

881 N O Q1b a bond Me bond NH S NH T3a OH

882 N O Q1b a bond Me bond NH S NH T3b OH

883 N O Q1b a bond Me bond NH S NH T3c OH

884 N O Q1b a bond Me bond NH S NH T3d OH

885 N O Q1b a bond Me bond NH S NH T3e OH

886 N O Q1b a bond Me bond NH S NH T3f OH

887 N O Q1b a bond Me bond NH S NH T3g OH

888 N O Q1b a bond Me bond NH S NH T3h OH

889 N O Q1b a bond Me bond NH S NH T3i OH

890 N O Q1b a bond Me bond NH S NH T3j OH

891 N O Q1b a bond Me bond NH S a bond T3a OH

892 N O Q1b a bond Me bond NH S a bond T3b OH

893 N O Q1b a bond Me bond NH S a bond T3c OH

894 N O Q1b a bond Me bond NH S a bond T3d OH

895 N O Q1b a bond Me bond NH S a bond T3e OH

896 N O Q1b a bond Me bond NH S a bond T3f OH

897 N O Q1b a bond Me bond NH S a bond T3g OH

898 N O Q1b a bond Me bond NH S a bond T3h OH

899 N O Q1b a bond Me bond NH S a bond T3i OH

900 N O Q1b a bond Me bond NH S a bond T3j OH

901 N O Q1b a bond Me bond NH O NH T3a OH

902 N O Q1b a bond Me St the z NH O NH T3b OH

903 N O Q1b a bond Me bond NH O NH T3c OH

904 N O Q1b a bond Me bond NH O NH T3d OH

905 N O Q1b a bond Me bond NH O NH T3e OH

906 N O Q1b a bond Me bond NH O NH T3f OH

907 N O Q1b a bond Me bond NH O NH T3g OH

908 N O Q1b a bond Me bond NH O NH T3h OH

909 N O Q1b a bond Me bond NH O NH T3i OH

910 N O Q1b a bond Me bond NH O NH T3j OH

911 N O Q1b a bond Me bond NH O a bond T3a OH

912 N O Q1b a bond Me bond NH O a bond T3b OH

913 N O Q1b a bond Me bond NH O a bond T3c OH

914 N O Q1b a bond Me bond NH O a bond T3d OH

915 N O Q1b a bond Me bond NH O a bond T3e OH

916 N O Q1b a bond Me bond NH O a bond T3f OH

917 N O Q1b a bond Me bond NH O a bond T3g OH

918 N O Q1b a bond Me bond NH O a bond T3h OH

919 N O Q1b a bond Me bond NH O a bond T3i OH

920 N O Q1b a bond Me bond NH O a bond T3j OH

921 N O Q1b a bond H a bond NH S NH T3a OH

922 N O Q1b a bond H a bond NH S NH T3b OH

923 N O Q1b a bond H a bond NH S NH T3c OH

924 N O Q1b a bond H a bond NH S NH T3d OH

925 N O Q1b a bond H a bond NH S NH T3e OH

926 N O Q1b a bond H a bond NH S NH T3f OH

927 N O Q1b a bond H a bond NH S NH T3g OH

928 N O Q1b a bond H a bond NH S NH T3h OH

929 N O Q1b a bond H a bond NH S NH T3i OH

930 N O Q1b a bond H a bond NH S NH T3j OH

931 N O Q1b a bond H a bond NH S a bond T3a OH

932 N O Q1b a bond H a bond NH S a bond T3b OH

933 N O Q1b a bond H a bond NH S a bond T3c OH

934 N O Q1b a bond H a bond NH S a bond T3d OH

935 N O Q1b a bond H a bond NH S a bond T3e OH

936 N O Q1b a bond H a bond NH S a bond T3f OH

937 N O Q1b a bond H a bond NH S a bond T3g OH

938 N O Q1b a bond H a bond NH S a bond T3h OH

939 N O Q1b a bond H a bond NH S a bond T3i OH

940 N O Q1b a bond H a bond NH S the ligature T3j OH

941 N O Q1b a bond H a bond NH O NH T3a OH

942 N O Q1b a bond H a bond NH O NH T3b OH

943 N O Q1b a bond H a bond NH O NH T3c OH

944 N O Q1b a bond H a bond NH O NH T3d OH

945 N O Q1b a bond H a bond NH O NH T3e OH

946 N O Q1b a bond H a bond NH O NH T3f OH

947 N O Q1b a bond H a bond NH O NH T3g OH

948 N O Q1b a bond H a bond NH O NH T3h OH

949 N O Q1b a bond H a bond NH O NH T3i OH

950 N O Q1b a bond H a bond NH O NH T3j OH

951 N O Q1b a bond H a bond NH O a bond T3a OH

952 N O Q1b a bond H a bond NH O a bond T3b OH

953 N O Q1b a bond H a bond NH O a bond T3c OH

954 N O Q1b a bond H a bond NH O a bond T3d OH

955 N O Q1b a bond H a bond NH O a bond T3e OH

956 N O Q1b a bond H a bond NH O a bond T3f OH

957 N O Q1b a bond H a bond NH O a bond T3g OH

958 N O Q1b a bond H a bond NH O a bond T3h OH

959 N O Q1b a bond H a bond NH O a bond T3i OH

960 N O Q1b a bond H a bond NH O a bond T3j OH

961 N O Q1c a bond Me bond NH S NH T3a OH

962 N O Q1c a bond Me bond NH S NH T3b OH

963 N O Q1c a bond Me bond NH S NH T3c OH

964 N O Q1c a bond Me bond NH S NH T3d OH

965 N O Q1c a bond Me bond NH S NH T3e OH

966 N O Q1c a bond Me bond NH S NH T3f OH

967 N O Q1c a bond Me bond NH S NH T3g OH

968 N O Q1c a bond Me bond NH S NH T3h OH

969 N O Q1c a bond Me bond NH S NH T3i OH

970 N O Q1c a bond Me bond NH S NH T3j OH

971 N O Q1c a bond Me bond NH S a bond T3a OH

972 N O Q1c a bond Me bond NH S a bond T3b OH

973 N O Q1c a bond Me bond NH S a bond T3c OH

974 N O Q1c a bond Me bond NH S a bond T3d OH

975 N O Q1c a bond Me bond NH S a bond T3e OH

976 N O Q1c a bond Me bond NH S a bond T3f OH

977 N O Q1c a bond Me bond NH S a bond T3g OH

978 N O Q1c a bond Me bond NH S a bond T3h OH/p>

979 N O Q1c a bond Me bond NH S a bond T3i OH

980 N O Q1c a bond Me bond NH S a bond T3j OH

981 N O Q1c a bond Me bond NH O NH T3a OH

982 N O Q1c a bond Me bond NH O NH T3b OH

983 N O Q1c a bond Me bond NH O NH T3c OH

984 N O Q1c a bond Me bond NH O NH T3d OH

985 N O Q1c a bond Me bond NH O NH T3e OH

986 N O Q1c a bond Me bond NH O NH T3f OH

987 N O Q1c a bond Me bond NH O NH T3g OH

988 N O Q1c a bond Me bond NH O NH T3h OH

989 N O Q1c a bond Me bond NH O NH T3i OH

990 N O Q1c a bond Me bond NH O NH T3j OH

991 N O Q1c a bond Me bond NH O a bond T3a OH

992 N O Q1c a bond Me bond NH O a bond T3b OH

993 N O Q1c a bond Me bond NH O a bond T3c OH

994 N O Q1c a bond Me bond NH O a bond T3d OH

995 N O Q1c a bond Me bond NH O a bond T3e OH

996 N O Q1c a bond Me bond NH O a bond T3f OH

997 N O Q1c a bond Me bond NH O a bond T3g OH

998 N O Q1c a bond Me bond NH O a bond T3h OH

999 N O Q1c a bond Me bond NH O a bond T3i OH

1000 N O Q1c a bond Me bond NH O a bond T3j OH

1001 N O Q1c a bond H a bond NH S NH T3a OH

1002 N O Q1c a bond H a bond NH S NH T3b OH

1003 N O Q1c a bond H a bond NH S NH T3c OH

1004 N O Q1c a bond H a bond NH S NH T3d OH

1005 N O Q1c a bond H a bond NH S NH T3e OH

1006 N O Q1c a bond H a bond NH S NH T3f OH

1007 N O Q1c a bond H a bond NH S NH T3g OH

1008 N O Q1c a bond H a bond NH S NH T3h OH

1009 N O Q1c a bond H a bond NH S NH T3i OH

1010 N O Q1c a bond H a bond NH S NH T3j OH

1011 N O Q1c a bond H a bond NH S a bond T3a OH

1012 N O Q1c a bond H a bond NH S a bond T3b OH

1013 N O Q1c a bond H a bond NH S a bond T3c OH

1014 N O Q1c a bond H a bond NH S a bond T3d OH

1015 N O Q1c a bond H a bond NH S a bond T3e OH

1016 N O Q1c a bond H a bond NHS bond T3f OH

1017 N O Q1c a bond H a bond NH S a bond T3g OH

1018 N O Q1c a bond H a bond NH S a bond T3h OH

1019 N O Q1c a bond H a bond NH S a bond T3i OH

1020 N O Q1c a bond H a bond NH S a bond T3j OH

1021 N O Q1c a bond H a bond NH O NH T3a OH

1022 N O Q1c a bond H a bond NH O NH T3b OH

1023 N O Q1c a bond H a bond NH O NH T3c OH

1024 N O Q1c a bond H a bond NH O NH T3d OH

1025 N O Q1c a bond H a bond NH O NH T3e OH

1026 N O Q1c a bond H a bond NH O NH T3f OH

1027 N O Q1c a bond H a bond NH O NH T3g OH

1028 N O Q1c a bond H a bond NH O NH T3h OH

1029 N O Q1c a bond H a bond NH O NH T3i OH

1030 N O Q1c a bond H a bond NH O NH T3j OH

1031 N O Q1c a bond H a bond NH O a bond T3a OH

1032 N O Q1c a bond H a bond NH O a bond T3b OH

1033 N O Q1c a bond H a bond NH O a bond T3c OH

1034 N O Q1c a bond H a bond NH O a bond T3d OH

1035 N O Q1c a bond H a bond NH O a bond T3e OH

1036 N O Q1c a bond H a bond NH O a bond T3f OH

1037 N O Q1c a bond H a bond NH O a bond T3g OH

1038 N O Q1c a bond H a bond NH O a bond T3h OH

1039 N O Q1c a bond H a bond NH O a bond T3i OH

1040 N O Q1c a bond H a bond NH O a bond T3j OH

1041 N O Q1i a bond Me bond NH S NH T3a OH

1042 N O Q1i a bond Me bond NH S NH T3b OH

1043 N O Q1i a bond Me bond NH S NH T3c OH

1044 N O Q1i a bond Me bond NH S NH T3d OH

1045 N O Q1i a bond Me bond NH S NH T3e OH

1046 N O Q1i a bond Me bond NH S NH T3f OH

1047 N O Q1i a bond Me bond NH S NH T3g OH

1048 N O Q1i a bond Me bond NH S NH T3h OH

1049 N O Q1i a bond Me bond NH S NH T3i OH

1050 N O Q1i a bond Me bond NH S NH T3j OH

1051 N O Q1i a bond Me bond NH S a bond T3a OH

1052 N O Q1i a bond Me bond NH S a bond T3b OH

1053 N O Q1i a bond Me bond NH S a bond T3c OH

1054 N O Q1i a bond Meswani NH S a bond T3d OH

1055 N O Q1i a bond Me bond NH S a bond T3e OH

1056 N O Q1i a bond Me bond NH S a bond T3f OH

1057 N O Q1i a bond Me bond NH S a bond T3g OH

1058 N O Q1i a bond Me bond NH S a bond T3h OH

1059 N O Q1i a bond Me bond NH S a bond T3i OH

1060 N O Q1i a bond Me bond NH S a bond T3j OH

1061 N O Q1i a bond Me bond NH O NH T3a OH

1062 N O Q1i a bond Me bond NH O NH T3b OH

1063 N O Q1i a bond Me bond NH O NH T3c OH

1064 N O Q1i a bond Me bond NH O NH T3d OH

1065 N O Q1i a bond Me bond NH O NH T3e OH

1066 N O Q1i a bond Me bond NH O NH T3f OH

1067 N O Q1i a bond Me bond NH O NH T3g OH

1068 N O Q1i a bond Me bond NH O NH T3h OH

1069 N O Q1i a bond Me bond NH O NH T3i OH

1070 N O Q1i a bond Me bond NH O NH T3j OH

1071 N O Q1i a bond Me bond NH O a bond T3a OH

1072 N O Q1i a bond Me bond NH O a bond T3b OH

1073 N O Q1i a bond Me bond NH O a bond T3c OH

1074 N O Q1i a bond Me bond NH O a bond T3d OH

1075 N O Q1i a bond Me bond NH O a bond T3e OH

1076 N O Q1i a bond Me bond NH O a bond T3f OH

1077 N O Q1i a bond Me bond NH O a bond T3g OH

1078 N O Q1i a bond Me bond NH O a bond T3h OH

1079 N O Q1i a bond Me bond NH O a bond T3i OH

1080 N O Q1i a bond Me bond NH O a bond T3j OH

1081 N O Q1i a bond H a bond NH S NH T3a OH

1082 N O Q1i a bond H a bond NH S NH T3b OH

1083 N O Q1i a bond H a bond NH S NH T3c OH

1084 N O Q1i a bond H a bond NH S NH T3d OH

1085 N O Q1i a bond H a bond NH S NH T3e OH

1086 N O Q1i a bond H a bond NH S NH T3f OH

1087 N O Q1i a bond H a bond NH S NH T3g OH

1088 N O Q1i a bond H a bond NH S NH T3h OH

1089 N O Q1i a bond H a bond NH S NH T3i OH

1090 N O Q1i a bond H a bond NH S NH T3j OH

1091 N O Q1i a bond H a bond NH S a bond T3a OH

1092 N O Q1i the ligature H a bond NH S a bond T3b OH

1093 N O Q1i a bond H a bond NH S a bond T3c OH

1094 N O Q1i a bond H a bond NH S a bond T3d OH

1095 N O Q1i a bond H a bond NH S a bond T3e OH

1096 N O Q1i a bond H a bond NH S a bond T3f OH

1097 N O Q1i a bond H a bond NH S a bond T3g OH

1098 N O Q1i a bond H a bond NH S a bond T3h OH

1099 N O Q1i a bond H a bond NH S a bond T3i OH

1100 N O Q1i a bond H a bond NH S a bond T3j OH

1101 N O Q1i a bond H a bond NH O NH T3a OH

1102 N O Q1i a bond H a bond NH O NH T3b OH

1103 N O Q1i a bond H a bond NH O NH T3c OH

1104 N O Q1i a bond H a bond NH O NH T3d OH

1105 N O Q1i a bond H a bond NH O NH T3e OH

1106 N O Q1i a bond H a bond NH O NH T3f OH

1107 N O Q1i a bond H a bond NH O NH T3g OH

1108 N O Q1i a bond H a bond NH O NH T3h OH

1109 N O Q1i a bond H a bond NH O NH T3i OH

1110 N O Q1i a bond H a bond NH O NH T3j OH

1111 N O Q1i a bond H a bond NH O a bond T3a OH

1112 N O Q1i a bond H a bond NH O a bond T3b OH

1113 N O Q1i a bond H a bond NH O a bond T3c OH

1114 N O Q1i a bond H a bond NH O a bond T3d OH

1115 N O Q1i a bond H a bond NH O a bond T3e OH

1116 N O Q1i a bond H a bond NH O a bond T3f OH

1117 N O Q1i a bond H a bond NH O a bond T3g OH

1118 N O Q1i a bond H a bond NH O a bond T3h OH

1119 N O Q1i a bond H a bond NH O a bond T3i OH

1120 N O Q1i a bond H a bond NH O a bond T3j OH

1121 N O Q1j a bond Me bond NH S NH T3a OH

1122 N O Q1j a bond Me bond NH S NH T3b OH

1123 N O Q1j a bond Me bond NH S NH T3c OH

1124 N O Q1j a bond Me bond NH S NH T3d OH

1125 N O Q1j a bond Me bond NH S NH T3e OH

1126 N O Q1j a bond Me bond NH S NH T3f OH

1127 N O Q1j a bond Me bond NH S NH T3g OH

1128 N O Q1j a bond Me bond NH S NH T3h OH

1129 N O Q1j a bond Me bond NH S NH T3i OH

1130 N O Q1j tie is Me bond NH S NH T3j OH

1131 N O Q1j a bond Me bond NH S a bond T3a OH

1132 N O Q1j a bond Me bond NH S a bond T3b OH

1133 N O Q1j a bond Me bond NH S a bond T3c OH

1134 N O Q1j a bond Me bond NH S a bond T3d OH

1135 N O Q1j a bond Me bond NH S a bond T3e OH

1136 N O Q1j a bond Me bond NH S a bond T3f OH

1137 N O Q1j a bond Me bond NH S a bond T3g OH

1138 N O Q1j a bond Me bond NH S a bond T3h OH

1139 N O Q1j a bond Me bond NH S a bond T3i OH

1140 N O Q1j a bond Me bond NH S a bond T3j OH

1141 N O Q1j a bond Me bond NH O NH T3a OH

1142 N O Q1j a bond Me bond NH O NH T3b OH

1143 N O Q1j a bond Me bond NH O NH T3c OH

1144 N O Q1j a bond Me bond NH O NH T3d OH

1145 N O Q1j a bond Me bond NH O NH T3e OH

1146 N O Q1j a bond Me bond NH O NH T3f OH

1147 N O Q1j a bond Me bond NH O NH T3g OH

1148 N O Q1j a bond Me bond NH O NH T3h OH

1149 N O Q1j a bond Me bond NH O NH T3i OH

1150 N O Q1j a bond Me bond NH O NH T3j OH

1151 N O Q1j a bond Me bond NH O a bond T3a OH

1152 N O Q1j a bond Me bond NH O a bond T3b OH

1153 N O Q1j a bond Me bond NH O a bond T3c OH

1154 N O Q1j a bond Me bond NH O a bond T3d OH

1155 N O Q1j a bond Me bond NH O a bond T3e OH

1156 N O Q1j a bond Me bond NH O a bond T3f OH

1157 N O Q1j a bond Me bond NH O a bond T3g OH

1158 N O Q1j a bond Me bond NH O a bond T3h OH

1159 N O Q1j a bond Me bond NH O a bond T3i OH

1160 N O Q1j a bond Me bond NH O a bond T3j OH

1161 N O Q1j a bond H a bond NH S NH T3a OH

1162 N O Q1j a bond H a bond NH S NH T3b OH

1163 N O Q1j a bond H a bond NH S NH T3c OH

1164 N O Q1j a bond H a bond NH S NH T3d OH

1165 N O Q1j a bond H a bond NH S NH T3e OH

1166 N O Q1j a bond H a bond NH S NH T3f OH

1167 N O Q1j a bond H a bond NH S NH 3g OH

1168 N O Q1j a bond H a bond NH S NH T3h OH

1169 N O Q1j a bond H a bond NH S NH T3i OH

1170 N O Q1j a bond H a bond NH S NH T3j OH

1171 N O Q1j a bond H a bond NH S a bond T3a OH

1172 N O Q1j a bond H a bond NH S a bond T3b OH

1173 N O Q1j a bond H a bond NH S a bond T3c OH

1174 N O Q1j a bond H a bond NH S a bond T3d OH

1175 N O Q1j a bond H a bond NH S a bond T3e OH

1176 N O Q1j a bond H a bond NH S a bond T3f OH

1177 N O Q1j a bond H a bond NH S a bond T3g OH

1178 N O Q1j a bond H a bond NH S a bond T3h OH

1179 N O Q1j a bond H a bond NH S a bond T3i OH

1180 N O Q1j a bond H a bond NH S a bond T3j OH

1181 N O Q1j a bond H a bond NH O NH T3a OH

1182 N O Q1j a bond H a bond NH O NH T3b OH

1183 N O Q1j a bond H a bond NH O NH T3c OH

1184 N O Q1j a bond H a bond NH O NH T3d OH

1185 N O Q1j a bond H a bond NH O NH T3e OH

1186 N O Q1j a bond H a bond NH O NH T3f OH

1187 N O Q1j a bond H a bond NH O NH T3g OH

1188 N O Q1j a bond H a bond NH O NH T3h OH

1189 N O Q1j a bond H a bond NH O NH T3i OH

1190 N O Q1j a bond H a bond NH O NH T3j OH

1191 N O Q1j a bond H a bond NH O a bond T3a OH

1192 N O Q1j a bond H a bond NH O a bond T3b OH

1193 N O Q1j a bond H a bond NH O a bond T3c OH

1194 N O Q1j a bond H a bond NH O a bond T3d OH

1195 N O Q1j a bond H a bond NH O a bond T3e OH

1196 N O Q1j a bond H a bond NH O a bond T3f OH

1197 N O Q1j a bond H a bond NH O a bond T3g OH

1198 N O Q1j a bond H a bond NH O a bond T3h OH

1199 N O Q1j a bond H a bond NH O a bond T3i OH

1200 N O Q1j a bond H a bond NH O a bond T3j OH

1201 CH NMe Q1a a bond Me bond NH S NH T3a OH

1202 CH NMe Q1a a bond Me bond NH S NH T3b OH

1203 CH NMe Q1a a bond Me bond NH S NH T3c OH

1204 CH NMe Q1a a bond Me bond NH S NH T3d OH

1205 CH NMe Q1a a bond Me bond NH S NH T3e OH

1206 CH NMe Q1a a bond Me bond NH S NH T3f OH

1207 CH NMe Q1a a bond Me bond NH S NH T3g OH

1208 CH NMe Q1a a bond Me bond NH S NH T3h OH

1209 CH NMe Q1a a bond Me bond NH S NH T3i OH

1210 CH NMe Q1a a bond Me bond NH S NH T3j OH

1211 CH NMe Q1a a bond Me bond NH S a bond T3a OH

1212 CH NMe Q1a a bond Me bond NH S a bond T3b OH

1213 CH NMe Q1a a bond Me bond NH S a bond T3c OH

1214 CH NMe Q1a a bond Me bond NH S a bond T3d OH

1215 CH NMe Q1a a bond Me bond NH S a bond T3e OH

1216 CH NMe Q1a a bond Me bond NH S a bond T3f OH

1217 CH NMe Q1a a bond Me bond NH S a bond T3g OH

1218 CH NMe Q1a a bond Me bond NH S a bond T3h OH

1219 CH NMe Q1a a bond Me bond NH S a bond T3i OH

1220 CH NMe Q1a a bond Me bond NH S a bond T3j OH

1221 CH NMe Q1a a bond Me bond NH O NH T3a OH

1222 CH NMe Q1a a bond Me bond NH O NH T3b OH

1223 CH NMe Q1a a bond Me bond NH O NH T3c OH

1224 CH NMe Q1a a bond Me bond NH O NH T3d OH

1225 CH NMe Q1a a bond Me bond NH O NH T3e OH

1226 CH NMe Q1a a bond Me bond NH O NH T3f OH

1227 CH NMe Q1a a bond Me bond NH O NH T3g OH

1228 CH NMe Q1a a bond Me bond NH O NH T3h OH

1229 CH NMe Q1a a bond Me bond NH O NH T3i OH

1230 CH NMe Q1a a bond Me bond NH O NH T3j OH

1231 CH NMe Q1a a bond Me bond NH O a bond T3a OH

1232 CH NMe Q1a a bond Me bond NH O a bond T3b OH

1233 CH NMe Q1a a bond Me bond NH O a bond T3c OH

1234 CH NMe Q1a a bond Me bond NH O a bond T3d OH

1235 CH NMe Q1a a bond Me bond NH O a bond T3e OH

1236 CH NMe Q1a a bond Me bond NH O a bond T3f OH

1237 CH NMe Q1a a bond Me bond NH O a bond T3g OH

1238 CH NMe Q1a a bond Me bond NH O a bond T3h OH

1239 CH NMe Q1a a bond Me bond NH O a bond T3i OH

1240 CH NMe Q1a a bond Me bond NH O a bond T3j OH

1241 CH NMe Q1a a bond H a bond NH S NH T3a OH

1242 CH NMe Q1a a bond H a bond NH S NH T3b OH

1243 CH NMe Q1a a bond H a bond NH S NH T3c OH

1244 CH NMe Q1a a bond H a bond NH S NH T3d OH

1245 CH NMe Q1a a bond H a bond NH S NH T3e OH

1246 CH NMe Q1a a bond H a bond NH S NH T3f OH

1247 CH NMe Q1a a bond H a bond NH S NH T3g OH

1248 CH NMe Q1a a bond H a bond NH S NH T3h OH

1249 CH NMe Q1a a bond H a bond NH S NH T3i OH

1250 CH NMe Q1a a bond H a bond NH S NH T3j OH

1251 CH NMe Q1a a bond H a bond NH S a bond T3a OH

1252 CH NMe Q1a a bond H a bond NH S a bond T3b OH

1253 CH NMe Q1a a bond H a bond NH S a bond T3c OH

1254 CH NMe Q1a a bond H a bond NH S a bond T3d OH

1255 CH NMe Q1a a bond H a bond NH S a bond T3e OH

1256 CH NMe Q1a a bond H a bond NH S a bond T3f OH

1257 CH NMe Q1a a bond H a bond NH S a bond T3g OH

1258 CH NMe Q1a a bond H a bond NH S a bond T3h OH

1259 CH NMe Q1a a bond H a bond NH S a bond T3i OH

1260 CH NMe Q1a a bond H a bond NH S a bond T3j OH

1261 CH NMe Q1a a bond H a bond NH O NH T3a OH

1262 CH NMe Q1a a bond H a bond NH O NH T3b OH

1263 CH NMe Q1a a bond H a bond NH O NH T3c OH

1264 CH NMe Q1a a bond H a bond NH O NH T3d OH

1265 CH NMe Q1a a bond H a bond NH O NH T3e OH

1266 CH NMe Q1a a bond H a bond NH O NH T3f OH

1267 CH NMe Q1a a bond H a bond NH O NH T3g OH

1268 CH NMe Q1a a bond H a bond NH O NH T3h OH

1269 CH NMe Q1a a bond H a bond NH O NH T3i OH

1270 CH NMe Q1a a bond H a bond NH O NH T3j OH

1271 CH NMe Q1a a bond H a bond NH O a bond T3a OH

1272 CH NMe Q1a a bond H a bond NH O a bond T3b OH

1273 CH NMe Q1a a bond H a bond NH O a bond T3c OH

1274 CH NMe Q1a a bond H a bond NH O a bond T3d OH

1275 CH NMe Q1a a bond H a bond NH O a bond T3e OH

1276 CH NMe Q1a a bond H a bond NH O a bond T3f OH

127 CH NMe Q1a a bond H a bond NH O a bond T3g OH

1278 CH NMe Q1a a bond H a bond NH O a bond T3h OH

1279 CH NMe Q1a a bond H a bond NH O a bond T3i OH

1280 CH NMe Q1a a bond H a bond NH O a bond T3j OH

1281 CH NMe Q1b a bond Me bond NH S NH T3a OH

1282 CH NMe Q1b a bond Me bond NH S NH T3b OH

1283 CH NMe Q1b a bond Me bond NH S NH T3c OH

1284 CH NMe Q1b a bond Me bond NH S NH T3d OH

1285 CH NMe Q1b a bond Me bond NH S NH T3e OH

1286 CH NMe Q1b a bond Me bond NH S NH T3f OH

1287 CH NMe Q1b a bond Me bond NH S NH T3g OH

1288 CH NMe Q1b a bond Me bond NH S NH T3h OH

1289 CH NMe Q1b a bond Me bond NH S NH T3i OH

1290 CH NMe Q1b a bond Me bond NH S NH T3j OH

1291 CH NMe Q1b a bond Me bond NH S a bond T3a OH

1292 CH NMe Q1b a bond Me bond NH S a bond T3b OH

1293 CH NMe Q1b a bond Me bond NH S a bond T3c OH

1294 CH NMe Q1b a bond Me bond NH S a bond T3d OH

1295 CH NMe Q1b a bond Me bond NH S a bond T3e OH

1296 CH NMe Q1b a bond Me bond NH S a bond T3f OH

1297 CH NMe Q1b a bond Me bond NH S a bond T3g OH

1298 CH NMe Q1b a bond Me bond NH S a bond T3h OH

1299 CH NMe Q1b a bond Me bond NH S a bond T3i OH

1300 CH NMe Q1b a bond Me bond NH S a bond T3j OH

1301 CH NMe Q1b a bond Me bond NH O NH T3a OH

1302 CH NMe Q1b a bond Me bond NH O NH T3b OH

1303 CH NMe Q1b a bond Me bond NH O NH T3c OH

1304 CH NMe Q1b a bond Me bond NH O NH T3d OH

1305 CH NMe Q1b a bond Me bond NH O NH T3e OH

1306 CH NMe Q1b a bond Me bond NH O NH T3f OH

1307 CH NMe Q1b a bond Me bond NH O NH T3g OH

1308 CH NMe Q1b a bond Me bond NH O NH T3h OH

1309 CH NMe Q1b a bond Me bond NH O NH T3i OH

1310 CH NMe Q1b a bond Me bond NH O NH T3j OH

1311 CH NMe Q1b a bond Me bond NH O a bond T3a OH

1312 CH NMe Q1b a bond Me bond NH O a bond T3b OH

1313 CH NMe Q1b a bond Me tie is NH O a bond T3c OH

1314 CH NMe Q1b a bond Me bond NH O a bond T3d OH

1315 CH NMe Q1b a bond Me bond NH O a bond T3e OH

1316 CH NMe Q1b a bond Me bond NH O a bond T3f OH

1317 CH NMe Q1b a bond Me bond NH O a bond T3g OH

1318 CH NMe Q1b a bond Me bond NH O a bond T3h OH

1319 CH NMe Q1b a bond Me bond NH O a bond T3i OH

1320 CH NMe Q1b a bond Me bond NH O a bond T3j OH

1321 CH NMe Q1b a bond H a bond NH S NH T3a OH

1322 CH NMe Q1b a bond H a bond NH S NH T3b OH

1323 CH NMe Q1b a bond H a bond NH S NH T3c OH

1324 CH NMe Q1b a bond H a bond NH S NH T3d OH

1325 CH NMe Q1b a bond H a bond NH S NH T3e OH

1326 CH NMe Q1b a bond H a bond NH S NH T3f OH

1327 CH NMe Q1b a bond H a bond NH S NH T3g OH

1328 CH NMe Q1b a bond H a bond NH S NH T3h OH

1329 CH NMe Q1b a bond H a bond NH S NH T3i OH

1330 CH NMe Q1b a bond H a bond NH S NH T3j OH

1331 CH NMe Q1b a bond H a bond NH S a bond T3a OH

1332 CH NMe Q1b a bond H a bond NH S a bond T3b OH

1333 CH NMe Q1b a bond H a bond NH S a bond T3c OH

1334 CH NMe Q1b a bond H a bond NH S a bond T3d OH

1335 CH NMe Q1b a bond H a bond NH S a bond T3e OH

1336 CH NMe Q1b a bond H a bond NH S a bond T3f OH

1337 CH NMe Q1b a bond H a bond NH S a bond T3g OH

1338 CH NMe Q1b a bond H a bond NH S a bond T3h OH

1339 CH NMe Q1b a bond H a bond NH S a bond T3i OH

1340 CH NMe Q1b a bond H a bond NH S a bond T3j OH

1341 CH NMe Q1b a bond H a bond NH O NH T3a OH

1342 CH NMe Q1b a bond H a bond NH O NH T3b OH

1343 CH NMe Q1b a bond H a bond NH O NH T3c OH

1344 CH NMe Q1b a bond H a bond NH O NH T3d OH

1345 CH NMe Q1b a bond H a bond NH O NH T3e OH

1346 CH NMe Q1b a bond H a bond NH O NH T3f OH

1347 CH NMe Q1b a bond H a bond NH O NH T3g OH

1348 CH NMe Q1b a bond H a bond NH O NH T3h OH

1349 CH NMe Q1b a bond H a bond NH O NHT3i OH

1350 CH NMe Q1b a bond H a bond NH O NH T3j OH

1351 CH NMe Q1b a bond H a bond NH O a bond T3a OH

1352 CH NMe Q1b a bond H a bond NH O a bond T3b OH

1353 CH NMe Q1b a bond H a bond NH O a bond T3c OH

1354 CH NMe Q1b a bond H a bond NH O a bond T3d OH

1355 CH NMe Q1b a bond H a bond NH O a bond T3e OH

1356 CH NMe Q1b a bond H a bond NH O a bond T3f OH

1357 CH NMe Q1b a bond H a bond NH O a bond T3g OH

1358 CH NMe Q1b a bond H a bond NH O a bond T3h OH

1359 CH NMe Q1b a bond H a bond NH O a bond T3i OH

1360 CH NMe Q1b a bond H a bond NH O a bond T3j OH

1361 CH NMe Q1c a bond Me bond NH S NH T3a OH

1362 CH NMe Q1c a bond Me bond NH S NH T3b OH

1363 CH NMe Q1c a bond Me bond NH S NH T3c OH

1364 CH NMe Q1c a bond Me bond NH S NH T3d OH

1365 CH NMe Q1c a bond Me bond NH S NH T3e OH

1366 CH NMe Q1c a bond Me bond NH S NH T3f OH

1367 CH NMe Q1c a bond Me bond NH S NH T3g OH

1368 CH NMe Q1c a bond Me bond NH S NH T3h OH

1369 CH NMe Q1c a bond Me bond NH S NH T3i OH

1370 CH NMe Q1c a bond Me bond NH S NH T3j OH

1371 CH NMe Q1c a bond Me bond NH S a bond T3a OH

1372 CH NMe Q1c a bond Me bond NH S a bond T3b OH

1373 CH NMe Q1c a bond Me bond NH S a bond T3c OH

1374 CH NMe Q1c a bond Me bond NH S a bond T3d OH

1375 CH NMe Q1c a bond Me bond NH S a bond T3e OH

1376 CH NMe Q1c a bond Me bond NH S a bond T3f OH

1377 CH NMe Q1c a bond Me bond NH S a bond T3g OH

1378 CH NMe Q1c a bond Me bond NH S a bond T3h OH

1379 CH NMe Q1c a bond Me bond NH S a bond T3i OH

1380 CH NMe Q1c a bond Me bond NH S a bond T3j OH

1381 CH NMe Q1c a bond Me bond NH O NH T3a OH

1382 CH NMe Q1c a bond Me bond NH O NH T3b OH

1383 CH NMe Q1c a bond Me bond NH O NH T3c OH

1384 CH NMe Q1c a bond Me bond NH O NH T3d OH

1385 C NMe Q1c a bond Me bond NH O NH T3e OH

1386 CH NMe Q1c a bond Me bond NH O NH T3f OH

1387 CH NMe Q1c a bond Me bond NH O NH T3g OH

1388 CH NMe Q1c a bond Me bond NH O NH T3h OH

1389 CH NMe Q1c a bond Me bond NH O NH T3i OH

1390 CH NMe Q1c a bond Me bond NH O NH T3j OH

1391 CH NMe Q1c a bond Me bond NH O a bond T3a OH

1392 CH NMe Q1c a bond Me bond NH O a bond T3b OH

1393 CH NMe Q1c a bond Me bond NH O a bond T3c OH

1394 CH NMe Q1c a bond Me bond NH O a bond T3d OH

1395 CH NMe Q1c a bond Me bond NH O a bond T3e OH

1396 CH NMe Q1c a bond Me bond NH O a bond T3f OH

1397 CH NMe Q1c a bond Me bond NH O a bond T3g OH

1398 CH NMe Q1c a bond Me bond NH O a bond T3h OH

1399 CH NMe Q1c a bond Me bond NH O a bond T3i OH

1400 CH NMe Q1c a bond Me bond NH O a bond T3j OH

1401 CH NMe Q1c a bond H a bond NH S NH T3a OH

1402 CH NMe Q1c a bond H a bond NH S NH T3b OH

1403 CH NMe Q1c a bond H a bond NH S NH T3c OH

1404 CH NMe Q1c a bond H a bond NH S NH T3d OH

1405 CH NMe Q1c a bond H a bond NH S NH T3e OH

1406 CH NMe Q1c a bond H a bond NH S NH T3f OH

1407 CH NMe Q1c a bond H a bond NH S NH T3g OH

1408 CH NMe Q1c a bond H a bond NH S NH T3h OH

1409 CH NMe Q1c a bond H a bond NH S NH T3i OH

1410 CH NMe Q1c a bond H a bond NH S NH T3j OH

1411 CH NMe Q1c a bond H a bond NH S a bond T3a OH

1412 CH NMe Q1c a bond H a bond NH S a bond T3b OH

1413 CH NMe Q1c a bond H a bond NH S a bond T3c OH

1414 CH NMe Q1c a bond H a bond NH S a bond T3d OH

1415 CH NMe Q1c a bond H a bond NH S a bond T3e OH

1416 CH NMe Q1c a bond H a bond NH S a bond T3f OH

1417 CH NMe Q1c a bond H a bond NH S a bond T3g OH

1418 CH NMe Q1c a bond H a bond NH S a bond T3h OH

1419 CH NMe Q1c a bond H a bond NH S a bond T3i OH

1420 CH NMe Q1c a bond H a bond NH S a bond T3j OH

1421 CH NMe Q1c H a bond NH O NH T3a OH

1422 CH NMe Q1c a bond H a bond NH O NH T3b OH

1423 CH NMe Q1c a bond H a bond NH O NH T3c OH

1424 CH NMe Q1c a bond H a bond NH O NH T3d OH

1425 CH NMe Q1c a bond H a bond NH O NH T3e OH

1426 CH NMe Q1c a bond H a bond NH O NH T3f OH

1427 CH NMe Q1c a bond H a bond NH O NH T3g OH

1428 CH NMe Q1c a bond H a bond NH O NH T3h OH

1429 CH NMe Q1c a bond H a bond NH O NH T3i OH

1430 CH NMe Q1c a bond H a bond NH O NH T3j OH

1431 CH NMe Q1c a bond H a bond NH O a bond T3a OH

1432 CH NMe Q1c a bond H a bond NH O a bond T3b OH

1433 CH NMe Q1c a bond H a bond NH O a bond T3c OH

1434 CH NMe Q1c a bond H a bond NH O a bond T3d OH

1435 CH NMe Q1c a bond H a bond NH O a bond T3e OH

1436 CH NMe Q1c a bond H a bond NH O a bond T3f OH

1437 CH NMe Q1c a bond H a bond NH O a bond T3g OH

1438 CH NMe Q1c a bond H a bond NH O a bond T3h OH

1439 CH NMe Q1c a bond H a bond NH O a bond T3i OH

1440 CH NMe Q1c a bond H a bond NH O a bond T3j OH

1441 CH NMe Q1i a bond Me bond NH S NH T3a OH

1442 CH NMe Q1i a bond Me bond NH S NH T3b OH

1443 CH NMe Q1i a bond Me bond NH S NH T3c OH

1444 CH NMe Q1i a bond Me bond NH S NH T3d OH

1445 CH NMe Q1i a bond Me bond NH S NH T3e OH

1446 CH NMe Q1i a bond Me bond NH S NH T3f OH

1447 CH NMe Q1i a bond Me bond NH S NH T3g OH

1448 CH NMe Q1i a bond Me bond NH S NH T3h OH

1449 CH NMe Q1i a bond Me bond NH S NH T3i OH

1450 CH NMe Q1i a bond Me bond NH S NH T3j OH

1451 CH NMe Q1i a bond Me bond NH S a bond T3a OH

1452 CH NMe Q1i a bond Me bond NH S a bond T3b OH

1453 CH NMe Q1i a bond Me bond NH S a bond T3c OH

1454 CH NMe Q1i a bond Me bond NH S a bond T3d OH

1455 CH NMe Q1i a bond Me bond NH S a bond T3e OH

1456 CH NMe Q1i a bond Me bond NH S a bond T3f OH

1457 CH NMe Q1i a bond Me bond NH S the ligature T3g OH

1458 CH NMe Q1i a bond Me bond NH S a bond T3h OH

1459 CH NMe Q1i a bond Me bond NH S a bond T3i OH

1460 CH NMe Q1i a bond Me bond NH S a bond T3j OH

1461 CH NMe Q1i a bond Me bond NH O NH T3a OH

1462 CH NMe Q1i a bond Me bond NH O NH T3b OH

1463 CH NMe Q1i a bond Me bond NH O NH T3c OH

1464 CH NMe Q1i a bond Me bond NH O NH T3d OH

1465 CH NMe Q1i a bond Me bond NH O NH T3e OH

1466 CH NMe Q1i a bond Me bond NH O NH T3f OH

1467 CH NMe Q1i a bond Me bond NH O NH T3g OH

1468 CH NMe Q1i a bond Me bond NH O NH T3h OH

1469 CH NMe Q1i a bond Me bond NH O NH T3i OH

1470 CH NMe Q1i a bond Me bond NH O NH T3j OH

1471 CH NMe Q1i a bond Me bond NH O a bond T3a OH

1472 CH NMe Q1i a bond Me bond NH O a bond T3b OH

1473 CH NMe Q1i a bond Me bond NH O a bond T3c OH

1474 CH NMe Q1i a bond Me bond NH O a bond T3d OH

1475 CH NMe Q1i a bond Me bond NH O a bond T3e OH

1476 CH NMe Q1i a bond Me bond NH O a bond T3f OH

1477 CH NMe Q1i a bond Me bond NH O a bond T3g OH

1478 CH NMe Q1i a bond Me bond NH O a bond T3h OH

1479 CH NMe Q1i a bond Me bond NH O a bond T3i OH

1480 CH NMe Q1i a bond Me bond NH O a bond T3j OH

1481 CH NMe Q1i a bond H a bond NH S NH T3a OH

1482 CH NMe Q1i a bond H a bond NH S NH T3b OH

1483 CH NMe Q1i a bond H a bond NH S NH T3c OH

1484 CH NMe Q1i a bond H a bond NH S NH T3d OH

1485 CH NMe Q1i a bond H a bond NH S NH T3e OH

1486 CH NMe Q1i a bond H a bond NH S NH T3f OH

1487 CH NMe Q1i a bond H a bond NH S NH T3g OH

1488 CH NMe Q1i a bond H a bond NH S NH T3h OH

1489 CH NMe Q1i a bond H a bond NH S NH T3i OH

1490 CH NMe Q1i a bond H a bond NH S NH T3j OH

1491 CH NMe Q1i a bond H a bond NH S a bond T3a OH

1492 CH NMe Q1i a bond H a bond NH S a bond T3b OH

1493 CH NMe Q1i a bond H a bond NH S with the IDE T3c OH

1494 CH NMe Q1i a bond H a bond NH S a bond T3d OH

1495 CH NMe Q1i a bond H a bond NH S a bond T3e OH

1496 CH NMe Q1i a bond H a bond NH S a bond T3f OH

1497 CH NMe Q1i a bond H a bond NH S a bond T3g OH

1498 CH NMe Q1i a bond H a bond NH S a bond T3h OH

1499 CH NMe Q1i a bond H a bond NH S a bond T3i OH

1500 CH NMe Q1i a bond H a bond NH S a bond T3j OH

1501 CH NMe Q1i a bond H a bond NH O NH T3a OH

1502 CH NMe Q1i a bond H a bond NH O NH T3b OH

1503 CH NMe Q1i a bond H a bond NH O NH T3c OH

1504 CH NMe Q1i a bond H a bond NH O NH T3d OH

1505 CH NMe Q1i a bond H a bond NH O NH T3e OH

1506 CH NMe Q1i a bond H a bond NH O NH T3f OH

1507 CH NMe Q1i a bond H a bond NH O NH T3g OH

1508 CH NMe Q1i a bond H a bond NH O NH T3h OH

1509 CH NMe Q1i a bond H a bond NH O NH T3i OH

1510 CH NMe Q1i a bond H a bond NH O NH T3j OH

1511 CH NMe Q1i a bond H a bond NH O a bond T3a OH

1512 CH NMe Q1i a bond H a bond NH O a bond T3b OH

1513 CH NMe Q1i a bond H a bond NH O a bond T3c OH

1514 CH NMe Q1i a bond H a bond NH O a bond T3d OH

1515 CH NMe Q1i a bond H a bond NH O a bond T3e OH

1516 CH NMe Q1i a bond H a bond NH O a bond T3f OH

1517 CH NMe Q1i a bond H a bond NH O a bond T3g OH

1518 CH NMe Q1i a bond H a bond NH O a bond T3h OH

1519 CH NMe Q1i a bond H a bond NH O a bond T3i OH

1520 CH NMe Q1i a bond H a bond NH O a bond T3j OH

1521 CH NMe Q1j a bond Me bond NH S NH T3a OH

1522 CH NMe Q1j a bond Me bond NH S NH T3b OH

1523 CH NMe Q1j a bond Me bond NH S NH T3c OH

1524 CH NMe Q1j a bond Me bond NH S NH T3d OH

1525 CH NMe Q1j a bond Me bond NH S NH T3e OH

1526 CH NMe Q1j a bond Me bond NH S NH T3f OH

1527 CH NMe Q1j a bond Me bond NH S NH T3g OH

1528 CH NMe Q1j a bond Me bond NH S NH T3h OH

1529 CH NMe Q1j a bond Me bond NH S H T3i OH

1530 CH NMe Q1j a bond Me bond NH S NH T3j OH

1531 CH NMe Q1j a bond Me bond NH S a bond T3a OH

1532 CH NMe Q1j a bond Me bond NH S a bond T3b OH

1533 CH NMe Q1j a bond Me bond NH S a bond T3c OH

1534 CH NMe Q1j a bond Me bond NH S a bond T3d OH

1535 CH NMe Q1j a bond Me bond NH S a bond T3e OH

1536 CH NMe Q1j a bond Me bond NH S a bond T3f OH

1537 CH NMe Q1j a bond Me bond NH S a bond T3g OH

1538 CH NMe Q1j a bond Me bond NH S a bond T3h OH

1539 CH NMe Q1j a bond Me bond NH S a bond T3i OH

1540 CH NMe Q1j a bond Me bond NH S a bond T3j OH

1541 CH NMe Q1j a bond Me bond NH O NH T3a OH

1542 CH NMe Q1j a bond Me bond NH O NH T3b OH

1543 CH NMe Q1j a bond Me bond NH O NH T3c OH

1544 CH NMe Q1j a bond Me bond NH O NH T3d OH

1545 CH NMe Q1j a bond Me bond NH O NH T3e OH

1546 CH NMe Q1j a bond Me bond NH O NH T3f OH

1547 CH NMe Q1j a bond Me bond NH O NH T3g OH

1548 CH NMe Q1j a bond Me bond NH O NH T3h OH

1549 CH NMe Q1j a bond Me bond NH O NH T3i OH

1550 CH NMe Q1j a bond Me bond NH O NH T3j OH

1551 CH NMe Q1j a bond Me bond NH O a bond T3a OH

1552 CH NMe Q1j a bond Me bond NH O a bond T3b OH

1553 CH NMe Q1j a bond Me bond NH O a bond T3c OH

1554 CH NMe Q1j a bond Me bond NH O a bond T3d OH

1555 CH NMe Q1j a bond Me bond NH O a bond T3e OH

1556 CH NMe Q1j a bond Me bond NH O a bond T3f OH

1557 CH NMe Q1j a bond Me bond NH O a bond T3g OH

1558 CH NMe Q1j a bond Me bond NH O a bond T3h OH

1559 CH NMe Q1j a bond Me bond NH O a bond T3i OH

1560 CH NMe Q1j a bond Me bond NH O a bond T3j OH

1561 CH NMe Q1j a bond H a bond NH S NH T3a OH

1562 CH NMe Q1j a bond H a bond NH S NH T3b OH

1563 CH NMe Q1j a bond H a bond NH S NH T3c OH

1564 CH NMe Q1j a bond H a bond NH S NH T3d OH

1565 CH NMe Q1j a bond H a bond NH S NH T3e OH

1566 CH NMe Q1j a bond H a bond NH S NH T3f OH

1567 CH NMe Q1j a bond H a bond NH S NH T3g OH

1568 CH NMe Q1j a bond H a bond NH S NH T3h OH

1569 CH NMe Q1j a bond H a bond NH S NH T3i OH

1570 CH NMe Q1j a bond H a bond NH S NH T3j OH

1571 CH NMe Q1j a bond H a bond NH S a bond T3a OH

1572 CH NMe Q1j a bond H a bond NH S a bond T3b OH

1573 CH NMe Q1j a bond H a bond NH S a bond T3c OH

1574 CH NMe Q1j a bond H a bond NH S a bond T3d OH

1575 CH NMe Q1j a bond H a bond NH S a bond T3e OH

1576 CH NMe Q1j a bond H a bond NH S a bond T3f OH

1577 CH NMe Q1j a bond H a bond NH S a bond T3g OH

1578 CH NMe Q1j a bond H a bond NH S a bond T3h OH

1579 CH NMe Q1j a bond H a bond NH S a bond T3i OH

1580 CH NMe Q1j a bond H a bond NH S a bond T3j OH

1581 CH NMe Q1j a bond H a bond NH O NH T3a OH

1582 CH NMe Q1j a bond H a bond NH O NH T3b OH

1583 CH NMe Q1j a bond H a bond NH O NH T3c OH

1584 CH NMe Q1j a bond H a bond NH O NH T3d OH

1585 CH NMe Q1j a bond H a bond NH O NH T3e OH

1586 CH NMe Q1j a bond H a bond NH O NH T3f OH

1587 CH NMe Q1j a bond H a bond NH O NH T3g OH

1588 CH NMe Q1j a bond H a bond NH O NH T3h OH

1589 CH NMe Q1j a bond H a bond NH O NH T3i OH

1590 CH NMe Q1j a bond H a bond NH O NH T3j OH

1591 CH NMe Q1j a bond H a bond NH O a bond T3a OH

1592 CH NMe Q1j a bond H a bond NH O a bond T3b OH

1593 CH NMe Q1j a bond H a bond NH O a bond T3c OH

1594 CH NMe Q1j a bond H a bond NH O a bond T3d OH

1595 CH NMe Q1j a bond H a bond NH O a bond T3e OH

1596 CH NMe Q1j a bond H a bond NH O a bond T3f OH

1597 CH NMe Q1j a bond H a bond NH O a bond T3g OH

1598 CH NMe Q1j a bond H a bond NH O a bond T3h OH

1599 CH NMe Q1j a bond H a bond NH O a bond T3i OH

1600 CH NMe Q1j a bond H a bond NH O a bond T3j OH

1601 CH S Q1a a bond Me with the IDE NH S NH T3a OH

1602 CH S Q1a a bond Me bond NH S NH T3b OH

1603 CH S Q1a a bond Me bond NH S NH T3c OH

1604 CH S Q1a a bond Me bond NH S NH T3d OH

1605 CH S Q1a a bond Me bond NH S NH T3e OH

1606 CH S Q1a a bond Me bond NH S NH T3f OH

1607 CH S Q1a a bond Me bond NH S NH T3g OH

1608 CH S Q1a a bond Me bond NH S NH T3h OH

1609 CH S Q1a a bond Me bond NH S NH T3i OH

1610 CH S Q1a a bond Me bond NH S NH T3j OH

1611 CH S Q1a a bond Me bond NH S a bond T3a OH

1612 CH S Q1a a bond Me bond NH S a bond T3b OH

1613 CH S Q1a a bond Me bond NH S a bond T3c OH

1614 CH S Q1a a bond Me bond NH S a bond T3d OH

1615 CH S Q1a a bond Me bond NH S a bond T3e OH

1616 CH S Q1a a bond Me bond NH S a bond T3f OH

1617 CH S Q1a a bond Me bond NH S a bond T3g OH

1618 CH S Q1a a bond Me bond NH S a bond T3h OH

1619 CH S Q1a a bond Me bond NH S a bond T3i OH

1620 CH S Q1a a bond Me bond NH S a bond T3j OH

1621 CH S Q1a a bond Me bond NH O NH T3a OH

1622 CH S Q1a a bond Me bond NH O NH T3b OH

1623 CH S Q1a a bond Me bond NH O NH T3c OH

1624 CH S Q1a a bond Me bond NH O NH T3d OH

1625 CH S Q1a a bond Me bond NH O NH T3e OH

1626 CH S Q1a a bond Me bond NH O NH T3f OH

1627 CH S Q1a a bond Me bond NH O NH T3g OH

1628 CH S Q1a a bond Me bond NH O NH T3h OH

1629 CH S Q1a a bond Me bond NH O NH T3i OH

1630 CH S Q1a a bond Me bond NH O NH T3j OH

1631 CH S Q1a a bond Me bond NH O a bond T3a OH

1632 CH S Q1a a bond Me bond NH O a bond T3b OH

1633 CH S Q1a a bond Me bond NH O a bond T3c OH

1634 CH S Q1a a bond Me bond NH O a bond T3d OH

1635 CH S Q1a a bond Me bond NH O a bond T3e OH

1636 CH S Q1a a bond Me bond NH O a bond T3f OH

1637 CH S Q1a a bond Me bond NH O a bond T3g OH

1638 CH S Q1a a bond Meswani NH O a bond T3h OH

1639 CH S Q1a a bond Me bond NH O a bond T3i OH

1640 CH S Q1a a bond Me bond NH O a bond T3j OH

1641 CH S Q1a a bond H a bond NH S NH T3a OH

1642 CH S Q1a a bond H a bond NH S NH T3b OH

1643 CH S Q1a a bond H a bond NH S NH T3c OH

1644 CH S Q1a a bond H a bond NH S NH T3d OH

1645 CH S Q1a a bond H a bond NH S NH T3e OH

1646 CH S Q1a a bond H a bond NH S NH T3f OH

1647 CH S Q1a a bond H a bond NH S NH T3g OH

1648 CH S Q1a a bond H a bond NH S NH T3h OH

1649 CH S Q1a a bond H a bond NH S NH T3i OH

1650 CH S Q1a a bond H a bond NH S NH T3j OH

1651 CH S Q1a a bond H a bond NH S a bond T3a OH

1652 CH S Q1a a bond H a bond NH S a bond T3b OH

1653 CH S Q1a a bond H a bond NH S a bond T3c OH

1654 CH S Q1a a bond H a bond NH S a bond T3d OH

1655 CH S Q1a a bond H a bond NH S a bond T3e OH

1656 CH S Q1a a bond H a bond NH S a bond T3f OH

1657 CH S Q1a a bond H a bond NH S a bond T3g OH

1658 CH S Q1a a bond H a bond NH S a bond T3h OH

1659 CH S Q1a a bond H a bond NH S a bond T3i OH

1660 CH S Q1a a bond H a bond NH S a bond T3j OH

1661 CH S Q1a a bond H a bond NH O NH T3a OH

1662 CH S Q1a a bond H a bond NH O NH T3b OH

1663 CH S Q1a a bond H a bond NH O NH T3c OH

1664 CH S Q1a a bond H a bond NH O NH T3d OH

1665 CH S Q1a a bond H a bond NH O NH T3e OH

1666 CH S Q1a a bond H a bond NH O NH T3f OH

1667 CH S Q1a a bond H a bond NH O NH T3g OH

1668 CH S Q1a a bond H a bond NH O NH T3h OH

1669 CH S Q1a a bond H a bond NH O NH T3i OH

1670 CH S Q1a a bond H a bond NH O NH T3j OH

1671 CH S Q1a a bond H a bond NH O a bond T3a OH

1672 CH S Q1a a bond H a bond NH O a bond T3b OH

1673 CH S Q1a a bond H a bond NH O a bond T3c OH

1674 CH S Q1a a bond H a bond NH O a bond T3d OH

1675 CH S Q1a a bond H a bond NH O a bond T3e OH

676 CH S Q1a a bond H a bond NH O a bond T3f OH

1677 CH S Q1a a bond H a bond NH O a bond T3g OH

1678 CH S Q1a a bond H a bond NH O a bond T3h OH

1679 CH S Q1a a bond H a bond NH O a bond T3i OH

1680 CH S Q1a a bond H a bond NH O a bond T3j OH

1681 CH S Q1b a bond Me bond NH S NH T3a OH

1682 CH S Q1b a bond Me bond NH S NH T3b OH

1683 CH S Q1b a bond Me bond NH S NH T3c OH

1684 CH S Q1b a bond Me bond NH S NH T3d OH

1685 CH S Q1b a bond Me bond NH S NH T3e OH

1686 CH S Q1b a bond Me bond NH S NH T3f OH

1687 CH S Q1b a bond Me bond NH S NH T3g OH

1688 CH S Q1b a bond Me bond NH S NH T3h OH

1689 CH S Q1b a bond Me bond NH S NH T3i OH

1690 CH S Q1b a bond Me bond NH S NH T3j OH

1691 CH S Q1b a bond Me bond NH S a bond T3a OH

1692 CH S Q1b a bond Me bond NH S a bond T3b OH

1693 CH S Q1b a bond Me bond NH S a bond T3c OH

1694 CH S Q1b a bond Me bond NH S a bond T3d OH

1695 CH S Q1b a bond Me bond NH S a bond T3e OH

1696 CH S Q1b a bond Me bond NH S a bond T3f OH

1697 CH S Q1b a bond Me bond NH S a bond T3g OH

1698 CH S Q1b a bond Me bond NH S a bond T3h OH

1699 CH S Q1b a bond Me bond NH S a bond T3i OH

1700 CH S Q1b a bond Me bond NH S a bond T3j OH

1701 CH S Q1b a bond Me bond NH O NH T3a OH

1702 CH S Q1b a bond Me bond NH O NH T3b OH

1703 CH S Q1b a bond Me bond NH O NH T3c OH

1704 CH S Q1b a bond Me bond NH O NH T3d OH

1705 CH S Q1b a bond Me bond NH O NH T3e OH

1706 CH S Q1b a bond Me bond NH O NH T3f OH

1707 CH S Q1b a bond Me bond NH O NH T3g OH

1708 CH S Q1b a bond Me bond NH O NH T3h OH

1709 CH S Q1b a bond Me bond NH O NH T3i OH

1710 CH S Q1b a bond Me bond NH O NH T3j OH

1711 CH S Q1b a bond Me bond NH O a bond T3a OH

1712 CH S Q1b a bond Me bond NH O a bond T3b OH

1713 CH S Q1b a bond Me bond H O a bond T3c OH

1714 CH S Q1b a bond Me bond NH O a bond T3d OH

1715 CH S Q1b a bond Me bond NH O a bond T3e OH

1716 CH S Q1b a bond Me bond NH O a bond T3f OH

1717 CH S Q1b a bond Me bond NH O a bond T3g OH

1718 CH S Q1b a bond Me bond NH O a bond T3h OH

1719 CH S Q1b a bond Me bond NH O a bond T3i OH

1720 CH S Q1b a bond Me bond NH O a bond T3j OH

1721 CH S Q1b a bond H a bond NH S NH T3a OH

1722 CH S Q1b a bond H a bond NH S NH T3b OH

1723 CH S Q1b a bond H a bond NH S NH T3c OH

1724 CH S Q1b a bond H a bond NH S NH T3d OH

1725 CH S Q1b a bond H a bond NH S NH T3e OH

1726 CH S Q1b a bond H a bond NH S NH T3f OH

1727 CH S Q1b a bond H a bond NH S NH T3g OH

1728 CH S Q1b a bond H a bond NH S NH T3h OH

1729 CH S Q1b a bond H a bond NH S NH T3i OH

1730 CH S Q1b a bond H a bond NH S NH T3j OH

1731 CH S Q1b a bond H a bond NH S a bond T3a OH

1732 CH S Q1b a bond H a bond NH S a bond T3b OH

1733 CH S Q1b a bond H a bond NH S a bond T3c OH

1734 CH S Q1b a bond H a bond NH S a bond T3d OH

1735 CH S Q1b a bond H a bond NH S a bond T3e OH

1736 CH S Q1b a bond H a bond NH S a bond T3f OH

1737 CH S Q1b a bond H a bond NH S a bond T3g OH

1738 CH S Q1b a bond H a bond NH S a bond T3h OH

1739 CH S Q1b a bond H a bond NH S a bond T3i OH

1740 CH S Q1b a bond H a bond NH S a bond T3j OH

1741 CH S Q1b a bond H a bond NH O NH T3a OH

1742 CH S Q1b a bond H a bond NH O NH T3b OH

1743 CH S Q1b a bond H a bond NH O NH T3c OH

1744 CH S Q1b a bond H a bond NH O NH T3d OH

1745 CH S Q1b a bond H a bond NH O NH T3e OH

1746 CH S Q1b a bond H a bond NH O NH T3f OH

1747 CH S Q1b a bond H a bond NH O NH T3g OH

1748 CH S Q1b a bond H a bond NH O NH T3h OH

1749 CH S Q1b a bond H a bond NH O NH T3i OH

1750 CH S Q1b a bond H a bond NH O NH T3j OH

1751 CH S Q1b a bond H a bond NH O a bond T3a OH

1752 CH S Q1b a bond H a bond NH O a bond T3b OH

1753 CH S Q1b a bond H a bond NH O a bond T3c OH

1754 CH S Q1b a bond H a bond NH O a bond T3d OH

1755 CH S Q1b a bond H a bond NH O a bond T3e OH

1756 CH S Q1b a bond H a bond NH O a bond T3f OH

1757 CH S Q1b a bond H a bond NH O a bond T3g OH

1758 CH S Q1b a bond H a bond NH O a bond T3h OH

1759 CH S Q1b a bond H a bond NH O a bond T3i OH

1760 CH S Q1b a bond H a bond NH O a bond T3j OH

1761 CH S Q1c a bond Me bond NH S NH T3a OH

1762 CH S Q1c a bond Me bond NH S NH T3b OH

1763 CH S Q1c a bond Me bond NH S NH T3c OH

1764 CH S Q1c a bond Me bond NH S NH T3d OH

1765 CH S Q1c a bond Me bond NH S NH T3e OH

1766 CH S Q1c a bond Me bond NH S NH T3f OH

1767 CH S Q1c a bond Me bond NH S NH T3g OH

1768 CH S Q1c a bond Me bond NH S NH T3h OH

1769 CH S Q1c a bond Me bond NH S NH T3i OH

1770 CH S Q1c a bond Me bond NH S NH T3j OH

1771 CH S Q1c a bond Me bond NH S a bond T3a OH

1772 CH S Q1c a bond Me bond NH S a bond T3b OH

1773 CH S Q1c a bond Me bond NH S a bond T3c OH

1774 CH S Q1c a bond Me bond NH S a bond T3d OH

1775 CH S Q1c a bond Me bond NH S a bond T3e OH

1776 CH S Q1c a bond Me bond NH S a bond T3f OH

1777 CH S Q1c a bond Me bond NH S a bond T3g OH

1778 CH S Q1c a bond Me bond NH S a bond T3h OH

1779 CH S Q1c a bond Me bond NH S a bond T3i OH

1780 CH S Q1c a bond Me bond NH S a bond T3j OH

1781 CH S Q1c a bond Me bond NH O NH T3a OH

1782 CH S Q1c a bond Me bond NH O NH T3b OH

1783 CH S Q1c a bond Me bond NH O NH T3c OH

1784 CH S Q1c a bond Me bond NH O NH T3d OH

1785 CH S Q1c a bond Me bond NH O NH T3e OH

1786 CH S Q1c a bond Me bond NH O NH T3f OH

1787 CH S Q1c with the IDE Me bond NH O NH T3g OH

1788 CH S Q1c a bond Me bond NH O NH T3h OH

1789 CH S Q1c a bond Me bond NH O NH T3i OH

1790 CH S Q1c a bond Me bond NH O NH T3j OH

1791 CH S Q1c a bond Me bond NH O a bond T3a OH

1792 CH S Q1c a bond Me bond NH O a bond T3b OH

1793 CH S Q1c a bond Me bond NH O a bond T3c OH

1794 CH S Q1c a bond Me bond NH O a bond T3d OH

1795 CH S Q1c a bond Me bond NH O a bond T3e OH

1796 CH S Q1c a bond Me bond NH O a bond T3f OH

1797 CH S Q1c a bond Me bond NH O a bond T3g OH

1798 CH S Q1c a bond Me bond NH O a bond T3h OH

1799 CH S Q1c a bond Me bond NH O a bond T3i OH

1800 CH S Q1c a bond Me bond NH O a bond T3j OH

1801 CH S Q1c a bond H a bond NH S NH T3a OH

1802 CH S Q1c a bond H a bond NH S NH T3b OH

1803 CH S Q1c a bond H a bond NH S NH T3c OH

1804 CH S Q1c a bond H a bond NH S NH T3d OH

1805 CH S Q1c a bond H a bond NH S NH T3e OH

1806 CH S Q1c a bond H a bond NH S NH T3f OH

1807 CH S Q1c a bond H a bond NH S NH T3g OH

1808 CH S Q1c a bond H a bond NH S NH T3h OH

1809 CH S Q1c a bond H a bond NH S NH T3i OH

1810 CH S Q1c a bond H a bond NH S NH T3j OH

1811 CH S Q1c a bond H a bond NH S a bond T3a OH

1812 CH S Q1c a bond H a bond NH S a bond T3b OH

1813 CH S Q1c a bond H a bond NH S a bond T3c OH

1814 CH S Q1c a bond H a bond NH S a bond T3d OH

1815 CH S Q1c a bond H a bond NH S a bond T3e OH

1816 CH S Q1c a bond H a bond NH S a bond T3f OH

1817 CH S Q1c a bond H a bond NH S a bond T3g OH

1818 CH S Q1c a bond H a bond NH S a bond T3h OH

1819 CH S Q1c a bond H a bond NH S a bond T3i OH

1820 CH S Q1c a bond H a bond NH S a bond T3j OH

1821 CH S Q1c a bond H a bond NH O NH T3a OH

1822 CH S Q1c a bond H a bond NH O NH T3b OH

1823 CH S Q1c a bond H a bond NH O NH T3c OH

1824 CH S Q1c a bond Swazi NH O NH T3d OH

1825 CH S Q1c a bond H a bond NH O NH T3e OH

1826 CH S Q1c a bond H a bond NH O NH T3f OH

1827 CH S Q1c a bond H a bond NH O NH T3g OH

1828 CH S Q1c a bond H a bond NH O NH T3h OH

1829 CH S Q1c a bond H a bond NH O NH T3i OH

1830 CH S Q1c a bond H a bond NH O NH T3j OH

1831 CH S Q1c a bond H a bond NH O a bond T3a OH

1832 CH S Q1c a bond H a bond NH O a bond T3b OH

1833 CH S Q1c a bond H a bond NH O a bond T3c OH

1834 CH S Q1c a bond H a bond NH O a bond T3d OH

1835 CH S Q1c a bond H a bond NH O a bond T3e OH

1836 CH S Q1c a bond H a bond NH O a bond T3f OH

1837 CH S Q1c a bond H a bond NH O a bond T3g OH

1838 CH S Q1c a bond H a bond NH O a bond T3h OH

1839 CH S Q1c a bond H a bond NH O a bond T3i OH

1840 CH S Q1c a bond H a bond NH O a bond T3j OH

1841 CH S Q1i a bond Me bond NH S NH T3a OH

1842 CH S Q1i a bond Me bond NH S NH T3b OH

1843 CH S Q1i a bond Me bond NH S NH T3c OH

1844 CH S Q1i a bond Me bond NH S NH T3d OH

1845 CH S Q1i a bond Me bond NH S NH T3e OH

1846 CH S Q1i a bond Me bond NH S NH T3f OH

1847 CH S Q1i a bond Me bond NH S NH T3g OH

1848 CH S Q1i a bond Me bond NH S NH T3h OH

1849 CH S Q1i a bond Me bond NH S NH T3i OH

1850 CH S Q1i a bond Me bond NH S NH T3j OH

1851 CH S Q1i a bond Me bond NH S a bond T3a OH

1852 CH S Q1i a bond Me bond NH S a bond T3b OH

1853 CH S Q1i a bond Me bond NH S a bond T3c OH

1854 CH S Q1i a bond Me bond NH S a bond T3d OH

1855 CH S Q1i a bond Me bond NH S a bond T3e OH

1856 CH S Q1i a bond Me bond NH S a bond T3f OH

1857 CH S Q1i a bond Me bond NH S a bond T3g OH

1858 CH S Q1i a bond Me bond NH S a bond T3h OH

1859 CH S Q1i a bond Me bond NH S a bond T3i OH

1860 CH S Q1i a bond Me bond NH S a bond T3j OH

1861 CH S Q1i St. the z Me bond NH O NH T3a OH

1862 CH S Q1i a bond Me bond NH O NH T3b OH

1863 CH S Q1i a bond Me bond NH O NH T3c OH

1864 CH S Q1i a bond Me bond NH O NH T3d OH

1865 CH S Q1i a bond Me bond NH O NH T3e OH

1866 CH S Q1i a bond Me bond NH O NH T3f OH

1867 CH S Q1i a bond Me bond NH O NH T3g OH

1868 CH S Q1i a bond Me bond NH O NH T3h OH

1869 CH S Q1i a bond Me bond NH O NH T3i OH

1870 CH S Q1i a bond Me bond NH O NH T3j OH

1871 CH S Q1i a bond Me bond NH O a bond T3a OH

1872 CH S Q1i a bond Me bond NH O a bond T3b OH

1873 CH S Q1i a bond Me bond NH O a bond T3c OH

1874 CH S Q1i a bond Me bond NH O a bond T3d OH

1875 CH S Q1i a bond Me bond NH O a bond T3e OH

1876 CH S Q1i a bond Me bond NH O a bond T3f OH

1877 CH S Q1i a bond Me bond NH O a bond T3g OH

1878 CH S Q1i a bond Me bond NH O a bond T3h OH

1879 CH S Q1i a bond Me bond NH O a bond T3i OH

1880 CH S Q1i a bond Me bond NH O a bond T3j OH

1881 CH S Q1i a bond H a bond NH S NH T3a OH

1882 CH S Q1i a bond H a bond NH S NH T3b OH

1883 CH S Q1i a bond H a bond NH S NH T3c OH

1884 CH S Q1i a bond H a bond NH S NH T3d OH

1885 CH S Q1i a bond H a bond NH S NH T3e OH

1886 CH S Q1i a bond H a bond NH S NH T3f OH

1887 CH S Q1i a bond H a bond NH S NH T3g OH

1888 CH S Q1i a bond H a bond NH S NH T3h OH

1889 CH S Q1i a bond H a bond NH S NH T3i OH

1890 CH S Q1i a bond H a bond NH S NH T3j OH

1891 CH S Q1i a bond H a bond NH S a bond T3a OH

1892 CH S Q1i a bond H a bond NH S a bond T3b OH

1893 CH S Q1i a bond H a bond NH S a bond T3c OH

1894 CH S Q1i a bond H a bond NH S a bond T3d OH

1895 CH S Q1i a bond H a bond NH S a bond T3e OH

1896 CH S Q1i a bond H a bond NH S a bond T3f OH

1897 CH S Q1i a bond H a bond NH S a bond T3g OH

1898 CH S Q1i a bond H a bond NH S the ligature T3h OH

1899 CH S Q1i a bond H a bond NH S a bond T3i OH

1900 CH S Q1i a bond H a bond NH S a bond T3j OH

1901 CH S Q1i a bond H a bond NH O NH T3a OH

1902 CH S Q1i a bond H a bond NH O NH T3b OH

1903 CH S Q1i a bond H a bond NH O NH T3c OH

1904 CH S Q1i a bond H a bond NH O NH T3d OH

1905 CH S Q1i a bond H a bond NH O NH T3e OH

1906 CH S Q1i a bond H a bond NH O NH T3f OH

1907 CH S Q1i a bond H a bond NH O NH T3g OH

1908 CH S Q1i a bond H a bond NH O NH T3h OH

1909 CH S Q1i a bond H a bond NH O NH T3i OH

1910 CH S Q1i a bond H a bond NH O NH T3j OH

1911 CH S Q1i a bond H a bond NH O a bond T3a OH

1912 CH S Q1i a bond H a bond NH O a bond T3b OH

1913 CH S Q1i a bond H a bond NH O a bond T3c OH

1914 CH S Q1i a bond H a bond NH O a bond T3d OH

1915 CH S Q1i a bond H a bond NH O a bond T3e OH

1916 CH S Q1i a bond H a bond NH O a bond T3f OH

1917 CH S Q1i a bond H a bond NH O a bond T3g OH

1918 CH S Q1i a bond H a bond NH O a bond T3h OH

1919 CH S Q1i a bond H a bond NH O a bond T3i OH

1920 CH S Q1i a bond H a bond NH O a bond T3j OH

1921 CH S Q1j a bond Me bond NH S NH T3a OH

1922 CH S Q1j a bond Me bond NH S NH T3b OH

1923 CH S Q1j a bond Me bond NH S NH T3c OH

1924 CH S Q1j a bond Me bond NH S NH T3d OH

1925 CH S Q1j a bond Me bond NH S NH T3e OH

1926 CH S Q1j a bond Me bond NH S NH T3f OH

1927 CH S Q1j a bond Me bond NH S NH T3g OH

1928 CH S Q1j a bond Me bond NH S NH T3h OH

1929 CH S Q1j a bond Me bond NH S NH T3i OH

1930 CH S Q1j a bond Me bond NH S NH T3j OH

1931 CH S Q1j a bond Me bond NH S a bond T3a OH

1932 CH S Q1j a bond Me bond NH S a bond T3b OH

1933 CH S Q1j a bond Me bond NH S a bond T3c OH

1934 CH S Q1j a bond Me bond NH S a bond T3d OH

1935 CH S Q1j a bond Me bond NH S a bond T3 OH

1936 CH S Q1j a bond Me bond NH S a bond T3f OH

1937 CH S Q1j a bond Me bond NH S a bond T3g OH

1938 CH S Q1j a bond Me bond NH S a bond T3h OH

1939 CH S Q1j a bond Me bond NH S a bond T3i OH

1940 CH S Q1j a bond Me bond NH S a bond T3j OH

1941 CH S Q1j a bond Me bond NH O NH T3a OH

1942 CH S Q1j a bond Me bond NH O NH T3b OH

1943 CH S Q1j a bond Me bond NH O NH T3c OH

1944 CH S Q1j a bond Me bond NH O NH T3d OH

1945 CH S Q1j a bond Me bond NH O NH T3e OH

1946 CH S Q1j a bond Me bond NH O NH T3f OH

1947 CH S Q1j a bond Me bond NH O NH T3g OH

1948 CH S Q1j a bond Me bond NH O NH T3h OH

1949 CH S Q1j a bond Me bond NH O NH T3i OH

1950 CH S Q1j a bond Me bond NH O NH T3j OH

1951 CH S Q1j a bond Me bond NH O a bond T3a OH

1952 CH S Q1j a bond Me bond NH O a bond T3b OH

1953 CH S Q1j a bond Me bond NH O a bond T3c OH

1954 CH S Q1j a bond Me bond NH O a bond T3d OH

1955 CH S Q1j a bond Me bond NH O a bond T3e OH

1956 CH S Q1j a bond Me bond NH O a bond T3f OH

1957 CH S Q1j a bond Me bond NH O a bond T3g OH

1958 CH S Q1j a bond Me bond NH O a bond T3h OH

1959 CH S Q1j a bond Me bond NH O a bond T3i OH

1960 CH S Q1j a bond Me bond NH O a bond T3j OH

1961 CH S Q1j a bond H a bond NH S NH T3a OH

1962 CH S Q1j a bond H a bond NH S NH T3b OH

1963 CH S Q1j a bond H a bond NH S NH T3c OH

1964 CH S Q1j a bond H a bond NH S NH T3d OH

1965 CH S Q1j a bond H a bond NH S NH T3e OH

1966 CH S Q1j a bond H a bond NH S NH T3f OH

1967 CH S Q1j a bond H a bond NH S NH T3g OH

1968 CH S Q1j a bond H a bond NH S NH T3h OH

1969 CH S Q1j a bond H a bond NH S NH T3i OH

1970 CH S Q1j a bond H a bond NH S NH T3j OH

1971 CH S Q1j a bond H a bond NH S a bond T3a OH

1972 CH S Q1j a bond H a bond NH S with the IDE T3b OH

1973 CH S Q1j a bond H a bond NH S a bond T3c OH

1974 CH S Q1j a bond H a bond NH S a bond T3d OH

1975 CH S Q1j a bond H a bond NH S a bond T3e OH

1976 CH S Q1j a bond H a bond NH S a bond T3f OH

1977 CH S Q1j a bond H a bond NH S a bond T3g OH

1978 CH S Q1j a bond H a bond NH S a bond T3h OH

1979 CH S Q1j a bond H a bond NH S a bond T3i OH

1980 CH S Q1j a bond H a bond NH S a bond T3j OH

1981 CH S Q1j a bond H a bond NH O NH T3a OH

1982 CH S Q1j a bond H a bond NH O NH T3b OH

1983 CH S Q1j a bond H a bond NH O NH T3c OH

1984 CH S Q1j a bond H a bond NH O NH T3d OH

1985 CH S Q1j a bond H a bond NH O NH T3e OH

1986 CH S Q1j a bond H a bond NH O NH T3f OH

1987 CH S Q1j a bond H a bond NH O NH T3g OH

1988 CH S Q1j a bond H a bond NH O NH T3h OH

1989 CH S Q1j a bond H a bond NH O NH T3i OH

1990 CH S Q1j a bond H a bond NH O NH T3j OH

1991 CH S Q1j a bond H a bond NH O a bond T3a OH

1992 CH S Q1j a bond H a bond NH O a bond T3b OH

1993 CH S Q1j a bond H a bond NH O a bond T3c OH

1994 CH S Q1j a bond H a bond NH O a bond T3d OH

1995 CH S Q1j a bond H a bond NH O a bond T3e OH

1996 CH S Q1j a bond H a bond NH O a bond T3f OH

1997 CH S Q1j a bond H a bond NH O a bond T3g OH

1998 CH S Q1j a bond H a bond NH O a bond T3h OH

1999 CH S Q1j a bond H a bond NH O a bond T3i OH

2000 CH S Q1j a bond H a bond NH O a bond T3j OH

2001 CH O Q1a a bond Me bond NH S NH T3a OH

2002 CH O Q1a a bond Me bond NH S NH T3b OH

2003 CH O Q1a a bond Me bond NH S NH T3c OH

2004 CH O Q1a a bond Me bond NH S NH T3d OH

2005 CH O Q1a a bond Me bond NH S NH T3e OH

2006 CH O Q1a a bond Me bond NH S NH T3f OH

2007 CH O Q1a a bond Me bond NH S NH T3g OH

2008 CH O Q1a a bond Me bond NH S NH T3h OH

2009 CH O Q1a a bond Me bond NH S NH 3i OH

2010 CH O Q1a a bond Me bond NH S NH T3j OH

2011 CH O Q1a a bond Me bond NH S a bond T3a OH

2012 CH O Q1a a bond Me bond NH S a bond T3b OH

2013 CH O Q1a a bond Me bond NH S a bond T3c OH

2014 CH O Q1a a bond Me bond NH S a bond T3d OH

2015 CH O Q1a a bond Me bond NH S a bond T3e OH

2016 CH O Q1a a bond Me bond NH S a bond T3f OH

2017 CH O Q1a a bond Me bond NH S a bond T3g OH

2018 CH O Q1a a bond Me bond NH S a bond T3h OH

2019 CH O Q1a a bond Me bond NH S a bond T3i OH

2020 CH O Q1a a bond Me bond NH S a bond T3j OH

2021 CH O Q1a a bond Me bond NH O NH T3a OH

2022 CH O Q1a a bond Me bond NH O NH T3b OH

2023 CH O Q1a a bond Me bond NH O NH T3c OH

2024 CH O Q1a a bond Me bond NH O NH T3d OH

2025 CH O Q1a a bond Me bond NH O NH T3e OH

2026 CH O Q1a a bond Me bond NH O NH T3f OH

2027 CH O Q1a a bond Me bond NH O NH T3g OH

2028 CH O Q1a a bond Me bond NH O NH T3h OH

2029 CH O Q1a a bond Me bond NH O NH T3i OH

2030 CH O Q1a a bond Me bond NH O NH T3j OH

2031 CH O Q1a a bond Me bond NH O a bond T3a OH

2032 CH O Q1a a bond Me bond NH O a bond T3b OH

2033 CH O Q1a a bond Me bond NH O a bond T3c OH

2034 CH O Q1a a bond Me bond NH O a bond T3d OH

2035 CH O Q1a a bond Me bond NH O a bond T3e OH

2036 CH O Q1a a bond Me bond NH O a bond T3f OH

2037 CH O Q1a a bond Me bond NH O a bond T3g OH

2038 CH O Q1a a bond Me bond NH O a bond T3h OH

2039 CH O Q1a a bond Me bond NH O a bond T3i OH

2040 CH O Q1a a bond Me bond NH O a bond T3j OH

2041 CH O Q1a a bond H a bond NH S NH T3a OH

2042 CH O Q1a a bond H a bond NH S NH T3b OH

2043 CH O Q1a a bond H a bond NH S NH T3c OH

2044 CH O Q1a a bond H a bond NH S NH T3d OH

2045 CH O Q1a a bond H a bond NH S NH T3e OH

2046 CH Q1a a bond H a bond NH S NH T3f OH

2047 CH O Q1a a bond H a bond NH S NH T3g OH

2048 CH O Q1a a bond H a bond NH S NH T3h OH

2049 CH O Q1a a bond H a bond NH S NH T3i OH

2050 CH O Q1a a bond H a bond NH S NH T3j OH

2051 CH O Q1a a bond H a bond NH S a bond T3a OH

2052 CH O Q1a a bond H a bond NH S a bond T3b OH

2053 CH O Q1a a bond H a bond NH S a bond T3c OH

2054 CH O Q1a a bond H a bond NH S a bond T3d OH

2055 CH O Q1a a bond H a bond NH S a bond T3e OH

2056 CH O Q1a a bond H a bond NH S a bond T3f OH

2057 CH O Q1a a bond H a bond NH S a bond T3g OH

2058 CH O Q1a a bond H a bond NH S a bond T3h OH

2059 CH O Q1a a bond H a bond NH S a bond T3i OH

2060 CH O Q1a a bond H a bond NH S a bond T3j OH

2061 CH O Q1a a bond H a bond NH O NH T3a OH

2062 CH O Q1a a bond H a bond NH O NH T3b OH

2063 CH O Q1a a bond H a bond NH O NH T3c OH

2064 CH O Q1a a bond H a bond NH O NH T3d OH

2065 CH O Q1a a bond H a bond NH O NH T3e OH

2066 CH O Q1a a bond H a bond NH O NH T3f OH

2067 CH O Q1a a bond H a bond NH O NH T3g OH

2068 CH O Q1a a bond H a bond NH O NH T3h OH

2069 CH O Q1a a bond H a bond NH O NH T3i OH

2070 CH O Q1a a bond H a bond NH O NH T3j OH

2071 CH O Q1a a bond H a bond NH O a bond T3a OH

2072 CH O Q1a a bond H a bond NH O a bond T3b OH

2073 CH O Q1a a bond H a bond NH O a bond T3c OH

2074 CH O Q1a a bond H a bond NH O a bond T3d OH

2075 CH O Q1a a bond H a bond NH O a bond T3e OH

2076 CH O Q1a a bond H a bond NH O a bond T3f OH

2077 CH O Q1a a bond H a bond NH O a bond T3g OH

2078 CH O Q1a a bond H a bond NH O a bond T3h OH

2079 CH O Q1a a bond H a bond NH O a bond T3i OH

2080 CH O Q1a a bond H a bond NH O a bond T3j OH

2081 CH O Q1b a bond Me bond NH S NH T3a OH

2082 CH O Q1b a bond Me bond NH S NH T3b OH

2083 CH O Q1b a bond Me tie the NH S NH T3c OH

2084 CH O Q1b a bond Me bond NH S NH T3d OH

2085 CH O Q1b a bond Me bond NH S NH T3e OH

2086 CH O Q1b a bond Me bond NH S NH T3f OH

2087 CH O Q1b a bond Me bond NH S NH T3g OH

2088 CH O Q1b a bond Me bond NH S NH T3h OH

2089 CH O Q1b a bond Me bond NH S NH T3i OH

2090 CH O Q1b a bond Me bond NH S NH T3j OH

2091 CH O Q1b a bond Me bond NH S a bond T3a OH

2092 CH O Q1b a bond Me bond NH S a bond T3b OH

2093 CH O Q1b a bond Me bond NH S a bond T3c OH

2094 CH O Q1b a bond Me bond NH S a bond T3d OH

2095 CH O Q1b a bond Me bond NH S a bond T3e OH

2096 CH O Q1b a bond Me bond NH S a bond T3f OH

2097 CH O Q1b a bond Me bond NH S a bond T3g OH

2098 CH O Q1b a bond Me bond NH S a bond T3h OH

2099 CH O Q1b a bond Me bond NH S a bond T3i OH

2100 CH O Q1b a bond Me bond NH S a bond T3j OH

2101 CH O Q1b a bond Me bond NH O NH T3a OH

2102 CH O Q1b a bond Me bond NH O NH T3b OH

2103 CH O Q1b a bond Me bond NH O NH T3c OH

2104 CH O Q1b a bond Me bond NH O NH T3d OH

2105 CH O Q1b a bond Me bond NH O NH T3e OH

2106 CH O Q1b a bond Me bond NH O NH T3f OH

2107 CH O Q1b a bond Me bond NH O NH T3g OH

2108 CH O Q1b a bond Me bond NH O NH T3h OH

2109 CH O Q1b a bond Me bond NH O NH T3i OH

2110 CH O Q1b a bond Me bond NH O NH T3j OH

2111 CH O Q1b a bond Me bond NH O a bond T3a OH

2112 CH O Q1b a bond Me bond NH O a bond T3b OH

2113 CH O Q1b a bond Me bond NH O a bond T3c OH

2114 CH O Q1b a bond Me bond NH O a bond T3d OH

2115 CH O Q1b a bond Me bond NH O a bond T3e OH

2116 CH O Q1b a bond Me bond NH O a bond T3f OH

2117 CH O Q1b a bond Me bond NH O a bond T3g OH

2118 CH O Q1b a bond Me bond NH O a bond T3h OH

2119 CH O Q1b a bond Me bond NH O a bond T3i OH

2120 CH O Qb link Me bond NH O a bond T3j OH

2121 CH O Q1b a bond H a bond NH S NH T3a OH

2122 CH O Q1b a bond H a bond NH S NH T3b OH

2123 CH O Q1b a bond H a bond NH S NH T3c OH

2124 CH O Q1b a bond H a bond NH S NH T3d OH

2125 CH O Q1b a bond H a bond NH S NH T3e OH

2126 CH O Q1b a bond H a bond NH S NH T3f OH

2127 CH O Q1b a bond H a bond NH S NH T3g OH

2128 CH O Q1b a bond H a bond NH S NH T3h OH

2129 CH O Q1b a bond H a bond NH S NH T3i OH

2130 CH O Q1b a bond H a bond NH S NH T3j OH

2131 CH O Q1b a bond H a bond NH S a bond T3a OH

2132 CH O Q1b a bond H a bond NH S a bond T3b OH

2133 CH O Q1b a bond H a bond NH S a bond T3c OH

2134 CH O Q1b a bond H a bond NH S a bond T3d OH

2135 CH O Q1b a bond H a bond NH S a bond T3e OH

2136 CH O Q1b a bond H a bond NH S a bond T3f OH

2137 CH O Q1b a bond H a bond NH S a bond T3g OH

2138 CH O Q1b a bond H a bond NH S a bond T3h OH

2139 CH O Q1b a bond H a bond NH S a bond T3i OH

2140 CH O Q1b a bond H a bond NH S a bond T3j OH

2141 CH O Q1b a bond H a bond NH O NH T3a OH

2142 CH O Q1b a bond H a bond NH O NH T3b OH

2143 CH O Q1b a bond H a bond NH O NH T3c OH

2144 CH O Q1b a bond H a bond NH O NH T3d OH

2145 CH O Q1b a bond H a bond NH O NH T3e OH

2146 CH O Q1b a bond H a bond NH O NH T3f OH

2147 CH O Q1b a bond H a bond NH O NH T3g OH

2148 CH O Q1b a bond H a bond NH O NH T3h OH

2149 CH O Q1b a bond H a bond NH O NH T3i OH

2150 CH O Q1b a bond H a bond NH O NH T3j OH

2151 CH O Q1b a bond H a bond NH O a bond T3a OH

2152 CH O Q1b a bond H a bond NH O a bond T3b OH

2153 CH O Q1b a bond H a bond NH O a bond T3c OH

2154 CH O Q1b a bond H a bond NH O a bond T3d OH

2155 CH O Q1b a bond H a bond NH O a bond T3e OH

2156 CH O Q1b a bond H a bond NH O a bond T3f OH

2157 CH O Q1b a bond H a bond NH O a bond T3g OH

218 CH O Q1b a bond H a bond NH O a bond T3h OH

2159 CH O Q1b a bond H a bond NH O a bond T3i OH

2160 CH O Q1b a bond H a bond NH O a bond T3j OH

2161 CH O Q1c a bond Me bond NH S NH T3a OH

2162 CH O Q1c a bond Me bond NH S NH T3b OH

2163 CH O Q1c a bond Me bond NH S NH T3c OH

2164 CH O Q1c a bond Me bond NH S NH T3d OH

2165 CH O Q1c a bond Me bond NH S NH T3e OH

2166 CH O Q1c a bond Me bond NH S NH T3f OH

2167 CH O Q1c a bond Me bond NH S NH T3g OH

2168 CH O Q1c a bond Me bond NH S NH T3h OH

2169 CH O Q1c a bond Me bond NH S NH T3i OH

2170 CH O Q1c a bond Me bond NH S NH T3j OH

2171 CH O Q1c a bond Me bond NH S a bond T3a OH

2172 CH O Q1c a bond Me bond NH S a bond T3b OH

2173 CH O Q1c a bond Me bond NH S a bond T3c OH

2174 CH O Q1c a bond Me bond NH S a bond T3d OH

2175 CH O Q1c a bond Me bond NH S a bond T3e OH

2176 CH O Q1c a bond Me bond NH S a bond T3f OH

2177 CH O Q1c a bond Me bond NH S a bond T3g OH

2178 CH O Q1c a bond Me bond NH S a bond T3h OH

2179 CH O Q1c a bond Me bond NH S a bond T3i OH

2180 CH O Q1c a bond Me bond NH S a bond T3j OH

2181 CH O Q1c a bond Me bond NH O NH T3a OH

2182 CH O Q1c a bond Me bond NH O NH T3b OH

2183 CH O Q1c a bond Me bond NH O NH T3c OH

2184 CH O Q1c a bond Me bond NH O NH T3d OH

2185 CH O Q1c a bond Me bond NH O NH T3e OH

2186 CH O Q1c a bond Me bond NH O NH T3f OH

2187 CH O Q1c a bond Me bond NH O NH T3g OH

2188 CH O Q1c a bond Me bond NH O NH T3h OH

2189 CH O Q1c a bond Me bond NH O NH T3i OH

2190 CH O Q1c a bond Me bond NH O NH T3j OH

2191 CH O Q1c a bond Me bond NH O a bond T3a OH

2192 CH O Q1c a bond Me bond NH O a bond T3b OH

2193 CH O Q1c a bond Me bond NH O a bond T3c OH

2194 CH O Q1c a bond Me bond NH O a bond T3d OH

2195 CH O Q1c a bond Me tie is NH O a bond T3e OH

2196 CH O Q1c a bond Me bond NH O a bond T3f OH

2197 CH O Q1c a bond Me bond NH O a bond T3g OH

2198 CH O Q1c a bond Me bond NH O a bond T3h OH

2199 CH O Q1c a bond Me bond NH O a bond T3i OH

2200 CH O Q1c a bond Me bond NH O a bond T3j OH

2201 CH O Q1c a bond H a bond NH S NH T3a OH

2202 CH O Q1c a bond H a bond NH S NH T3b OH

2203 CH O Q1c a bond H a bond NH S NH T3c OH

2204 CH O Q1c a bond H a bond NH S NH T3d OH

2205 CH O Q1c a bond H a bond NH S NH T3e OH

2206 CH O Q1c a bond H a bond NH S NH T3f OH

2207 CH O Q1c a bond H a bond NH S NH T3g OH

2208 CH O Q1c a bond H a bond NH S NH T3h OH

2209 CH O Q1c a bond H a bond NH S NH T3i OH

2210 CH O Q1c a bond H a bond NH S NH T3j OH

2211 CH O Q1c a bond H a bond NH S a bond T3a OH

2212 CH O Q1c a bond H a bond NH S a bond T3b OH

2213 CH O Q1c a bond H a bond NH S a bond T3c OH

2214 CH O Q1c a bond H a bond NH S a bond T3d OH

2215 CH O Q1c a bond H a bond NH S a bond T3e OH

2216 CH O Q1c a bond H a bond NH S a bond T3f OH

2217 CH O Q1c a bond H a bond NH S a bond T3g OH

2218 CH O Q1c a bond H a bond NH S a bond T3h OH

2219 CH O Q1c a bond H a bond NH S a bond T3i OH

2220 CH O Q1c a bond H a bond NH S a bond T3j OH

2221 CH O Q1c a bond H a bond NH O NH T3a OH

2222 CH O Q1c a bond H a bond NH O NH T3b OH

2223 CH O Q1c a bond H a bond NH O NH T3c OH

2224 CH O Q1c a bond H a bond NH O NH T3d OH

2225 CH O Q1c a bond H a bond NH O NH T3e OH

2226 CH O Q1c a bond H a bond NH O NH T3f OH

2227 CH O Q1c a bond H a bond NH O NH T3g OH

2228 CH O Q1c a bond H a bond NH O NH T3h OH

2229 CH O Q1c a bond H a bond NH O NH T3i OH

2230 CH O Q1c a bond H a bond NH O NH T3j OH

2231 CH O Q1c a bond H a bond NH O a bond T3a OH

2232 CH O Q1c a bond H a bond NH O a bond T3b OH

<> 2233 CH O Q1c a bond H a bond NH O a bond T3c OH

2234 CH O Q1c a bond H a bond NH O a bond T3d OH

2235 CH O Q1c a bond H a bond NH O a bond T3e OH

2236 CH O Q1c a bond H a bond NH O a bond T3f OH

2237 CH O Q1c a bond H a bond NH O a bond T3g OH

2238 CH O Q1c a bond H a bond NH O a bond T3h OH

2239 CH O Q1c a bond H a bond NH O a bond T3i OH

2240 CH O Q1c a bond H a bond NH O a bond T3j OH

2241 CH O Q1i a bond Me bond NH S NH T3a OH

2242 CH O Q1i a bond Me bond NH S NH T3b OH

2243 CH O Q1i a bond Me bond NH S NH T3c OH

2244 CH O Q1i a bond Me bond NH S NH T3d OH

2245 CH O Q1i a bond Me bond NH S NH T3e OH

2246 CH O Q1i a bond Me bond NH S NH T3f OH

2247 CH O Q1i a bond Me bond NH S NH T3g OH

2248 CH O Q1i a bond Me bond NH S NH T3h OH

2249 CH O Q1i a bond Me bond NH S NH T3i OH

2250 CH O Q1i a bond Me bond NH S NH T3j OH

2251 CH O Q1i a bond Me bond NH S a bond T3a OH

2252 CH O Q1i a bond Me bond NH S a bond T3b OH

2253 CH O Q1i a bond Me bond NH S a bond T3c OH

2254 CH O Q1i a bond Me bond NH S a bond T3d OH

2255 CH O Q1i a bond Me bond NH S a bond T3e OH

2256 CH O Q1i a bond Me bond NH S a bond T3f OH

2257 CH O Q1i a bond Me bond NH S a bond T3g OH

2258 CH O Q1i a bond Me bond NH S a bond T3h OH

2259 CH O Q1i a bond Me bond NH S a bond T3i OH

2260 CH O Q1i a bond Me bond NH S a bond T3j OH

2261 CH O Q1i a bond Me bond NH O NH T3a OH

2262 CH O Q1i a bond Me bond NH O NH T3b OH

2263 CH O Q1i a bond Me bond NH O NH T3c OH

2264 CH O Q1i a bond Me bond NH O NH T3d OH

2265 CH O Q1i a bond Me bond NH O NH T3e OH

2266 CH O Q1i a bond Me bond NH O NH T3f OH

2267 CH O Q1i a bond Me bond NH O NH T3g OH

2268 CH O Q1i a bond Me bond NH O NH T3h OH

2269 CH O Q1i a bond Me St the z NH O NH T3i OH

2270 CH O Q1i a bond Me bond NH O NH T3j OH

2271 CH O Q1i a bond Me bond NH O a bond T3a OH

2272 CH O Q1i a bond Me bond NH O a bond T3b OH

2273 CH O Q1i a bond Me bond NH O a bond T3c OH

2274 CH O Q1i a bond Me bond NH O a bond T3d OH

2275 CH O Q1i a bond Me bond NH O a bond T3e OH

2276 CH O Q1i a bond Me bond NH O a bond T3f OH

2277 CH O Q1i a bond Me bond NH O a bond T3g OH

2278 CH O Q1i a bond Me bond NH O a bond T3h OH

2279 CH O Q1i a bond Me bond NH O a bond T3i OH

2280 CH O Q1i a bond Me bond NH O a bond T3j OH

2281 CH O Q1i a bond H a bond NH S NH T3a OH

2282 CH O Q1i a bond H a bond NH S NH T3b OH

2283 CH O Q1i a bond H a bond NH S NH T3c OH

2284 CH O Q1i a bond H a bond NH S NH T3d OH

2285 CH O Q1i a bond H a bond NH S NH T3e OH

2286 CH O Q1i a bond H a bond NH S NH T3f OH

2287 CH O Q1i a bond H a bond NH S NH T3g OH

2288 CH O Q1i a bond H a bond NH S NH T3h OH

2289 CH O Q1i a bond H a bond NH S NH T3i OH

2290 CH O Q1i a bond H a bond NH S NH T3j OH

2291 CH O Q1i a bond H a bond NH S a bond T3a OH

2292 CH O Q1i a bond H a bond NH S a bond T3b OH

2293 CH O Q1i a bond H a bond NH S a bond T3c OH

2294 CH O Q1i a bond H a bond NH S a bond T3d OH

2295 CH O Q1i a bond H a bond NH S a bond T3e OH

2296 CH O Q1i a bond H a bond NH S a bond T3f OH

2297 CH O Q1i a bond H a bond NH S a bond T3g OH

2298 CH O Q1i a bond H a bond NH S a bond T3h OH

2299 CH O Q1i a bond H a bond NH S a bond T3i OH

2300 CH O Q1i a bond H a bond NH S a bond T3j OH

2301 CH O Q1i a bond H a bond NH O NH T3a OH

2302 CH O Q1i a bond H a bond NH O NH T3b OH

2303 CH O Q1i a bond H a bond NH O NH T3c OH

2304 CH O Q1i a bond H a bond NH O NH T3d OH

2305 CH O Q1i a bond H a bond NH O NH T3e OH

2306 CH O Q1i a bond H the ligature NH O NH T3f OH

2307 CH O Q1i a bond H a bond NH O NH T3g OH

2308 CH O Q1i a bond H a bond NH O NH T3h OH

2309 CH O Q1i a bond H a bond NH O NH T3i OH

2310 CH O Q1i a bond H a bond NH O NH T3j OH

2311 CH O Q1i a bond H a bond NH O a bond T3a OH

2312 CH O Q1i a bond H a bond NH O a bond T3b OH

2313 CH O Q1i a bond H a bond NH O a bond T3c OH

2314 CH O Q1i a bond H a bond NH O a bond T3d OH

2315 CH O Q1i a bond H a bond NH O a bond T3e OH

2316 CH O Q1i a bond H a bond NH O a bond T3f OH

2317 CH O Q1i a bond H a bond NH O a bond T3g OH

2318 CH O Q1i a bond H a bond NH O a bond T3h OH

2319 CH O Q1i a bond H a bond NH O a bond T3i OH

2320 CH O Q1i a bond H a bond NH O a bond T3j OH

2321 CH O Q1j a bond Me bond NH S NH T3a OH

2322 CH O Q1j a bond Me bond NH S NH T3b OH

2323 CH O Q1j a bond Me bond NH S NH T3c OH

2324 CH O Q1j a bond Me bond NH S NH T3d OH

2325 CH O Q1j a bond Me bond NH S NH T3e OH

2326 CH O Q1j a bond Me bond NH S NH T3f OH

2327 CH O Q1j a bond Me bond NH S NH T3g OH

2328 CH O Q1j a bond Me bond NH S NH T3h OH

2329 CH O Q1j a bond Me bond NH S NH T3i OH

2330 CH O Q1j a bond Me bond NH S NH T3j OH

2331 CH O Q1j a bond Me bond NH S a bond T3a OH

2332 CH O Q1j a bond Me bond NH S a bond T3b OH

2333 CH O Q1j a bond Me bond NH S a bond T3c OH

2334 CH O Q1j a bond Me bond NH S a bond T3d OH

2335 CH O Q1j a bond Me bond NH S a bond T3e OH

2336 CH O Q1j a bond Me bond NH S a bond T3f OH

2337 CH O Q1j a bond Me bond NH S a bond T3g OH

2338 CH O Q1j a bond Me bond NH S a bond T3h OH

2339 CH O Q1j a bond Me bond NH S a bond T3i OH

2340 CH O Q1j a bond Me bond NH S a bond T3j OH

2341 CH O Q1j a bond Me bond NH O NH T3a OH

2342 CH O Q1j a bond Me bond NH O NH T3b OH

2343 CH O Q1j with the IDE Me bond NH O NH T3c OH

2344 CH O Q1j a bond Me bond NH O NH T3d OH

2345 CH O Q1j a bond Me bond NH O NH T3e OH

2346 CH O Q1j a bond Me bond NH O NH T3f OH

2347 CH O Q1j a bond Me bond NH O NH T3g OH

2348 CH O Q1j a bond Me bond NH O NH T3h OH

2349 CH O Q1j a bond Me bond NH O NH T3i OH

2350 CH O Q1j a bond Me bond NH O NH T3j OH

2351 CH O Q1j a bond Me bond NH O a bond T3a OH

2352 CH O Q1j a bond Me bond NH O a bond T3b OH

2353 CH O Q1j a bond Me bond NH O a bond T3c OH

2354 CH O Q1j a bond Me bond NH O a bond T3d OH

2355 CH O Q1j a bond Me bond NH O a bond T3e OH

2356 CH O Q1j a bond Me bond NH O a bond T3f OH

2357 CH O Q1j a bond Me bond NH O a bond T3g OH

2358 CH O Q1j a bond Me bond NH O a bond T3h OH

2359 CH O Q1j a bond Me bond NH O a bond T3i OH

2360 CH O Q1j a bond Me bond NH O a bond T3j OH

2361 CH O Q1j a bond H a bond NH S NH T3a OH

2362 CH O Q1j a bond H a bond NH S NH T3b OH

2363 CH O Q1j a bond H a bond NH S NH T3c OH

2364 CH O Q1j a bond H a bond NH S NH T3d OH

2365 CH O Q1j a bond H a bond NH S NH T3e OH

2366 CH O Q1j a bond H a bond NH S NH T3f OH

2367 CH O Q1j a bond H a bond NH S NH T3g OH

2368 CH O Q1j a bond H a bond NH S NH T3h OH

2369 CH O Q1j a bond H a bond NH S NH T3i OH

2370 CH O Q1j a bond H a bond NH S NH T3j OH

2371 CH O Q1j a bond H a bond NH S a bond T3a OH

2372 CH O Q1j a bond H a bond NH S a bond T3b OH

2373 CH O Q1j a bond H a bond NH S a bond T3c OH

2374 CH O Q1j a bond H a bond NH S a bond T3d OH

2375 CH O Q1j a bond H a bond NH S a bond T3e OH

2376 CH O Q1j a bond H a bond NH S a bond T3f OH

2377 CH O Q1j a bond H a bond NH S a bond T3g OH

2378 CH O Q1j a bond H a bond NH S a bond T3h OH

2379 CH O Q1j a bond H a bond NH S a bond T3i OH

2380 CH O Q1j a bond H with the IDE NH S a bond T3j OH

2381 CH O Q1j a bond H a bond NH O NH T3a OH

2382 CH O Q1j a bond H a bond NH O NH T3b OH

2383 CH O Q1j a bond H a bond NH O NH T3c OH

2384 CH O Q1j a bond H a bond NH O NH T3d OH

2385 CH O Q1j a bond H a bond NH O NH T3e OH

2386 CH O Q1j a bond H a bond NH O NH T3f OH

2387 CH O Q1j a bond H a bond NH O NH T3g OH

2388 CH O Q1j a bond H a bond NH O NH T3h OH

2389 CH O Q1j a bond H a bond NH O NH T3i OH

2390 CH O Q1j a bond H a bond NH O NH T3j OH

2391 CH O Q1j a bond H a bond NH O a bond T3a OH

2392 CH O Q1j a bond H a bond NH O a bond T3b OH

2393 CH O Q1j a bond H a bond NH O a bond T3c OH

2394 CH O Q1j a bond H a bond NH O a bond T3d OH

2395 CH O Q1j a bond H a bond NH O a bond T3e OH

2396 CH O Q1j a bond H a bond NH O a bond T3f OH

2397 CH O Q1j a bond H a bond NH O a bond T3g OH

2398 CH O Q1j a bond H a bond NH O a bond T3h OH

2399 CH O Q1j a bond H a bond NH O a bond T3i OH

2400 CH O Q1j a bond H a bond NH O a bond T3j OH

2401 CMe NMe Q1a a bond Me bond NH S NH T3a OH

2402 CMe NMe Q1a a bond Me bond NH S NH T3b OH

2403 CMe NMe Q1a a bond Me bond NH S NH T3c OH

2404 CMe NMe Q1a a bond Me bond NH S NH T3d OH

2405 CMe NMe Q1a a bond Me bond NH S NH T3e OH

2406 CMe NMe Q1a a bond Me bond NH S NH T3f OH

2407 CMe NMe Q1a a bond Me bond NH S NH T3g OH

2408 CMe NMe Q1a a bond Me bond NH S NH T3h OH

2409 CMe NMe Q1a a bond Me bond NH S NH T3i OH

2410 CMe NMe Q1a a bond Me bond NH S NH T3j OH

2411 CMe NMe Q1a a bond Me bond NH S a bond T3a OH

2412 CMe NMe Q1a a bond Me bond NH S a bond T3b OH

2413 CMe NMe Q1a a bond Me bond NH S a bond T3c OH

2414 CMe NMe Q1a a bond Me bond NH S a bond T3d OH

2415 CMe NMe Q1a a bond Me bond NH S a bond T3e OH

2416 CMe NMe Q1a a bond Me bond NH S a bond T3f OH

2417 CM NMe Q1a a bond Me bond NH S a bond T3g OH

2418 CMe NMe Q1a a bond Me bond NH S a bond T3h OH

2419 CMe NMe Q1a a bond Me bond NH S a bond T3i OH

2420 CMe NMe Q1a a bond Me bond NH S a bond T3j OH

2421 CMe NMe Q1a a bond Me bond NH O NH T3a OH

2422 CMe NMe Q1a a bond Me bond NH O NH T3b OH

2423 CMe NMe Q1a a bond Me bond NH O NH T3c OH

2424 CMe NMe Q1a a bond Me bond NH O NH T3d OH

2425 CMe NMe Q1a a bond Me bond NH O NH T3e OH

2426 CMe NMe Q1a a bond Me bond NH O NH T3f OH

2427 CMe NMe Q1a a bond Me bond NH O NH T3g OH

2428 CMe NMe Q1a a bond Me bond NH O NH T3h OH

2429 CMe NMe Q1a a bond Me bond NH O NH T3i OH

2430 CMe NMe Q1a a bond Me bond NH O NH T3j OH

2431 CMe NMe Q1a a bond Me bond NH O a bond T3a OH

2432 CMe NMe Q1a a bond Me bond NH O a bond T3b OH

2433 CMe NMe Q1a a bond Me bond NH O a bond T3c OH

2434 CMe NMe Q1a a bond Me bond NH O a bond T3d OH

2435 CMe NMe Q1a a bond Me bond NH O a bond T3e OH

2436 CMe NMe Q1a a bond Me bond NH O a bond T3f OH

2437 CMe NMe Q1a a bond Me bond NH O a bond T3g OH

2438 CMe NMe Q1a a bond Me bond NH O a bond T3h OH

2439 CMe NMe Q1a a bond Me bond NH O a bond T3i OH

2440 CMe NMe Q1a a bond Me bond NH O a bond T3j OH

2441 CMe NMe Q1a a bond H a bond NH S NH T3a OH

2442 CMe NMe Q1a a bond H a bond NH S NH T3b OH

2443 CMe NMe Q1a a bond H a bond NH S NH T3c OH

2444 CMe NMe Q1a a bond H a bond NH S NH T3d OH

2445 CMe NMe Q1a a bond H a bond NH S NH T3e OH

2446 CMe NMe Q1a a bond H a bond NH S NH T3f OH

2447 CMe NMe Q1a a bond H a bond NH S NH T3g OH

2448 CMe NMe Q1a a bond H a bond NH S NH T3h OH

2449 CMe NMe Q1a a bond H a bond NH S NH T3i OH

2450 CMe NMe Q1a a bond H a bond NH S NH T3j OH

2451 CMe NMe Q1a a bond H a bond NH S a bond T3a OH

2452 CMe NMe Q1a a bond H a bond NH S a bond T3b OH

2453 CMe NMeQ1a bond H a bond NH S a bond T3c OH

2454 CMe NMe Q1a a bond H a bond NH S a bond T3d OH

2455 CMe NMe Q1a a bond H a bond NH S a bond T3e OH

2456 CMe NMe Q1a a bond H a bond NH S a bond T3f OH

2457 CMe NMe Q1a a bond H a bond NH S a bond T3g OH

2458 CMe NMe Q1a a bond H a bond NH S a bond T3h OH

2459 CMe NMe Q1a a bond H a bond NH S a bond T3i OH

2460 CMe NMe Q1a a bond H a bond NH S a bond T3j OH

2461 CMe NMe Q1a a bond H a bond NH O NH T3a OH

2462 CMe NMe Q1a a bond H a bond NH O NH T3b OH

2463 CMe NMe Q1a a bond H a bond NH O NH T3c OH

2464 CMe NMe Q1a a bond H a bond NH O NH T3d OH

2465 CMe NMe Q1a a bond H a bond NH O NH T3e OH

2466 CMe NMe Q1a a bond H a bond NH O NH T3f OH

2467 CMe NMe Q1a a bond H a bond NH O NH T3g OH

2468 CMe NMe Q1a a bond H a bond NH O NH T3h OH

2469 CMe NMe Q1a a bond H a bond NH O NH T3i OH

2470 CMe NMe Q1a a bond H a bond NH O NH T3j OH

2471 CMe NMe Q1a a bond H a bond NH O a bond T3a OH

2472 CMe NMe Q1a a bond H a bond NH O a bond T3b OH

2473 CMe NMe Q1a a bond H a bond NH O a bond T3c OH

2474 CMe NMe Q1a a bond H a bond NH O a bond T3d OH

2475 CMe NMe Q1a a bond H a bond NH O a bond T3e OH

2476 CMe NMe Q1a a bond H a bond NH O a bond T3f OH

2477 CMe NMe Q1a a bond H a bond NH O a bond T3g OH

2478 CMe NMe Q1a a bond H a bond NH O a bond T3h OH

2479 CMe NMe Q1a a bond H a bond NH O a bond T3i OH

2480 CMe NMe Q1a a bond H a bond NH O a bond T3j OH

2481 CMe NMe Q1b a bond Me bond NH S NH T3a OH

2482 CMe NMe Q1b a bond Me bond NH S NH T3b OH

2483 CMe NMe Q1b a bond Me bond NH S NH T3c OH

2484 CMe NMe Q1b a bond Me bond NH S NH T3d OH

2485 CMe NMe Q1b a bond Me bond NH S NH T3e OH

2486 CMe NMe Q1b a bond Me bond NH S NH T3f OH

2487 CMe NMe Q1b a bond Me bond NH S NH T3g OH

2488 CMe NMe Q1b a bond Me bond NH S NH T3h OH

2489 CMe NM Q1b a bond Me bond NH S NH T3i OH

2490 CMe NMe Q1b a bond Me bond NH S NH T3j OH

2491 CMe NMe Q1b a bond Me bond NH S a bond T3a OH

2492 CMe NMe Q1b a bond Me bond NH S a bond T3b OH

2493 CMe NMe Q1b a bond Me bond NH S a bond T3c OH

2494 CMe NMe Q1b a bond Me bond NH S a bond T3d OH

2495 CMe NMe Q1b a bond Me bond NH S a bond T3e OH

2496 CMe NMe Q1b a bond Me bond NH S a bond T3f OH

2497 CMe NMe Q1b a bond Me bond NH S a bond T3g OH

2498 CMe NMe Q1b a bond Me bond NH S a bond T3h OH

2499 CMe NMe Q1b a bond Me bond NH S a bond T3i OH

2500 CMe NMe Q1b a bond Me bond NH S a bond T3j OH

2501 CMe NMe Q1b a bond Me bond NH O NH T3a OH

2502 CMe NMe Q1b a bond Me bond NH O NH T3b OH

2503 CMe NMe Q1b a bond Me bond NH O NH T3c OH

2504 CMe NMe Q1b a bond Me bond NH O NH T3d OH

2505 CMe NMe Q1b a bond Me bond NH O NH T3e OH

2506 CMe NMe Q1b a bond Me bond NH O NH T3f OH

2507 CMe NMe Q1b a bond Me bond NH O NH T3g OH

2508 CMe NMe Q1b a bond Me bond NH O NH T3h OH

2509 CMe NMe Q1b a bond Me bond NH O NH T3i OH

2510 CMe NMe Q1b a bond Me bond NH O NH T3j OH

2511 CMe NMe Q1b a bond Me bond NH O a bond T3a OH

2512 CMe NMe Q1b a bond Me bond NH O a bond T3b OH

2513 CMe NMe Q1b a bond Me bond NH O a bond T3c OH

2514 CMe NMe Q1b a bond Me bond NH O a bond T3d OH

2515 CMe NMe Q1b a bond Me bond NH O a bond T3e OH

2516 CMe NMe Q1b a bond Me bond NH O a bond T3f OH

2517 CMe NMe Q1b a bond Me bond NH O a bond T3g OH

2518 CMe NMe Q1b a bond Me bond NH O a bond T3h OH

2519 CMe NMe Q1b a bond Me bond NH O a bond T3i OH

2520 CMe NMe Q1b a bond Me bond NH O a bond T3j OH

2521 CMe NMe Q1b a bond H a bond NH S NH T3a OH

2522 CMe NMe Q1b a bond H a bond NH S NH T3b OH

2523 CMe NMe Q1b a bond H a bond NH S NH T3c OH

2524 CMe NMe Q1b a bond a bond NH S NH T3d OH

2525 CMe NMe Q1b a bond H a bond NH S NH T3e OH

2526 CMe NMe Q1b a bond H a bond NH S NH T3f OH

2527 CMe NMe Q1b a bond H a bond NH S NH T3g OH

2528 CMe NMe Q1b a bond H a bond NH S NH T3h OH

2529 CMe NMe Q1b a bond H a bond NH S NH T3i OH

2530 CMe NMe Q1b a bond H a bond NH S NH T3j OH

2531 CMe NMe Q1b a bond H a bond NH S a bond T3a OH

2532 CMe NMe Q1b a bond H a bond NH S a bond T3b OH

2533 CMe NMe Q1b a bond H a bond NH S a bond T3c OH

2534 CMe NMe Q1b a bond H a bond NH S a bond T3d OH

2535 CMe NMe Q1b a bond H a bond NH S a bond T3e OH

2536 CMe NMe Q1b a bond H a bond NH S a bond T3f OH

2537 CMe NMe Q1b a bond H a bond NH S a bond T3g OH

2538 CMe NMe Q1b a bond H a bond NH S a bond T3h OH

2539 CMe NMe Q1b a bond H a bond NH S a bond T3i OH

2540 CMe NMe Q1b a bond H a bond NH S a bond T3j OH

2541 CMe NMe Q1b a bond H a bond NH O NH T3a OH

2542 CMe NMe Q1b a bond H a bond NH O NH T3b OH

2543 CMe NMe Q1b a bond H a bond NH O NH T3c OH

2544 CMe NMe Q1b a bond H a bond NH O NH T3d OH

2545 CMe NMe Q1b a bond H a bond NH O NH T3e OH

2546 CMe NMe Q1b a bond H a bond NH O NH T3f OH

2547 CMe NMe Q1b a bond H a bond NH O NH T3g OH

2548 CMe NMe Q1b a bond H a bond NH O NH T3h OH

2549 CMe NMe Q1b a bond H a bond NH O NH T3i OH

2550 CMe NMe Q1b a bond H a bond NH O NH T3j OH

2551 CMe NMe Q1b a bond H a bond NH O a bond T3a OH

2552 CMe NMe Q1b a bond H a bond NH O a bond T3b OH

2553 CMe NMe Q1b a bond H a bond NH O a bond T3c OH

2554 CMe NMe Q1b a bond H a bond NH O a bond T3d OH

2555 CMe NMe Q1b a bond H a bond NH O a bond T3e OH

2556 CMe NMe Q1b a bond H a bond NH O a bond T3f OH

2557 CMe NMe Q1b a bond H a bond NH O a bond T3g OH

2558 CMe NMe Q1b a bond H a bond NH O a bond T3h OH

2559 CMe NMe Q1b a bond H a bond NH O a bond T3i OH

256 CMe NMe Q1b a bond H a bond NH O a bond T3j OH

2561 CMe NMe Q1c a bond Me bond NH S NH T3a OH

2562 CMe NMe Q1c a bond Me bond NH S NH T3b OH

2563 CMe NMe Q1c a bond Me bond NH S NH T3c OH

2564 CMe NMe Q1c a bond Me bond NH S NH T3d OH

2565 CMe NMe Q1c a bond Me bond NH S NH T3e OH

2566 CMe NMe Q1c a bond Me bond NH S NH T3f OH

2567 CMe NMe Q1c a bond Me bond NH S NH T3g OH

2568 CMe NMe Q1c a bond Me bond NH S NH T3h OH

2569 CMe NMe Q1c a bond Me bond NH S NH T3i OH

2570 CMe NMe Q1c a bond Me bond NH S NH T3j OH

2571 CMe NMe Q1c a bond Me bond NH S a bond T3a OH

2572 CMe NMe Q1c a bond Me bond NH S a bond T3b OH

2573 CMe NMe Q1c a bond Me bond NH S a bond T3c OH

2574 CMe NMe Q1c a bond Me bond NH S a bond T3d OH

2575 CMe NMe Q1c a bond Me bond NH S a bond T3e OH

2576 CMe NMe Q1c a bond Me bond NH S a bond T3f OH

2577 CMe NMe Q1c a bond Me bond NH S a bond T3g OH

2578 CMe NMe Q1c a bond Me bond NH S a bond T3h OH

2579 CMe NMe Q1c a bond Me bond NH S a bond T3i OH

2580 CMe NMe Q1c a bond Me bond NH S a bond T3j OH

2581 CMe NMe Q1c a bond Me bond NH O NH T3a OH

2582 CMe NMe Q1c a bond Me bond NH O NH T3b OH

2583 CMe NMe Q1c a bond Me bond NH O NH T3c OH

2584 CMe NMe Q1c a bond Me bond NH O NH T3d OH

2585 CMe NMe Q1c a bond Me bond NH O NH T3e OH

2586 CMe NMe Q1c a bond Me bond NH O NH T3f OH

2587 CMe NMe Q1c a bond Me bond NH O NH T3g OH

2588 CMe NMe Q1c a bond Me bond NH O NH T3h OH

2589 CMe NMe Q1c a bond Me bond NH O NH T3i OH

2590 CMe NMe Q1c a bond Me bond NH O NH T3j OH

2591 CMe NMe Q1c a bond Me bond NH O a bond T3a OH

2592 CMe NMe Q1c a bond Me bond NH O a bond T3b OH

2593 CMe NMe Q1c a bond Me bond NH O a bond T3c OH

2594 CMe NMe Q1c a bond Me bond NH O a bond T3d OH

2595 CMe NMe Q1c a bond Me bond NH O a bond T3e OH

596 CMe NMe Q1c a bond Me bond NH O a bond T3f OH

2597 CMe NMe Q1c a bond Me bond NH O a bond T3g OH

2598 CMe NMe Q1c a bond Me bond NH O a bond T3h OH

2599 CMe NMe Q1c a bond Me bond NH O a bond T3i OH

2600 CMe NMe Q1c a bond Me bond NH O a bond T3j OH

2601 CMe NMe Q1c a bond H a bond NH S NH T3a OH

2602 CMe NMe Q1c a bond H a bond NH S NH T3b OH

2603 CMe NMe Q1c a bond H a bond NH S NH T3c OH

2604 CMe NMe Q1c a bond H a bond NH S NH T3d OH

2605 CMe NMe Q1c a bond H a bond NH S NH T3e OH

2606 CMe NMe Q1c a bond H a bond NH S NH T3f OH

2607 CMe NMe Q1c a bond H a bond NH S NH T3g OH

2608 CMe NMe Q1c a bond H a bond NH S NH T3h OH

2609 CMe NMe Q1c a bond H a bond NH S NH T3i OH

2610 CMe NMe Q1c a bond H a bond NH S NH T3j OH

2611 CMe NMe Q1c a bond H a bond NH S a bond T3a OH

2612 CMe NMe Q1c a bond H a bond NH S a bond T3b OH

2613 CMe NMe Q1c a bond H a bond NH S a bond T3c OH

2614 CMe NMe Q1c a bond H a bond NH S a bond T3d OH

2615 CMe NMe Q1c a bond H a bond NH S a bond T3e OH

2616 CMe NMe Q1c a bond H a bond NH S a bond T3f OH

2617 CMe NMe Q1c a bond H a bond NH S a bond T3g OH

2618 CMe NMe Q1c a bond H a bond NH S a bond T3h OH

2619 CMe NMe Q1c a bond H a bond NH S a bond T3i OH

2620 CMe NMe Q1c a bond H a bond NH S a bond T3j OH

2621 CMe NMe Q1c a bond H a bond NH O NH T3a OH

2622 CMe NMe Q1c a bond H a bond NH O NH T3b OH

2623 CMe NMe Q1c a bond H a bond NH O NH T3c OH

2624 CMe NMe Q1c a bond H a bond NH O NH T3d OH

2625 CMe NMe Q1c a bond H a bond NH O NH T3e OH

2626 CMe NMe Q1c a bond H a bond NH O NH T3f OH

2627 CMe NMe Q1c a bond H a bond NH O NH T3g OH

2628 CMe NMe Q1c a bond H a bond NH O NH T3h OH

2629 CMe NMe Q1c a bond H a bond NH O NH T3i OH

2630 CMe NMe Q1c a bond H a bond NH O NH T3j OH

2631 CMe NMe Q1c a bond H a bond NH O a bond T3a OH

2632 CMe NMe Q1c a bond H the ligature NH O a bond T3b OH

2633 CMe NMe Q1c a bond H a bond NH O a bond T3c OH

2634 CMe NMe Q1c a bond H a bond NH O a bond T3d OH

2635 CMe NMe Q1c a bond H a bond NH O a bond T3e OH

2636 CMe NMe Q1c a bond H a bond NH O a bond T3f OH

2637 CMe NMe Q1c a bond H a bond NH O a bond T3g OH

2638 CMe NMe Q1c a bond H a bond NH O a bond T3h OH

2639 CMe NMe Q1c a bond H a bond NH O a bond T3i OH

2640 CMe NMe Q1c a bond H a bond NH O a bond T3j OH

2641 CMe NMe Q1i a bond Me bond NH S NH T3a OH

2642 CMe NMe Q1i a bond Me bond NH S NH T3b OH

2643 CMe NMe Q1i a bond Me bond NH S NH T3c OH

2644 CMe NMe Q1i a bond Me bond NH S NH T3d OH

2645 CMe NMe Q1i a bond Me bond NH S NH T3e OH

2646 CMe NMe Q1i a bond Me bond NH S NH T3f OH

2647 CMe NMe Q1i a bond Me bond NH S NH T3g OH

2648 CMe NMe Q1i a bond Me bond NH S NH T3h OH

2649 CMe NMe Q1i a bond Me bond NH S NH T3i OH

2650 CMe NMe Q1i a bond Me bond NH S NH T3j OH

2651 CMe NMe Q1i a bond Me bond NH S a bond T3a OH

2652 CMe NMe Q1i a bond Me bond NH S a bond T3b OH

2653 CMe NMe Q1i a bond Me bond NH S a bond T3c OH

2654 CMe NMe Q1i a bond Me bond NH S a bond T3d OH

2655 CMe NMe Q1i a bond Me bond NH S a bond T3e OH

2656 CMe NMe Q1i a bond Me bond NH S a bond T3f OH

2657 CMe NMe Q1i a bond Me bond NH S a bond T3g OH

2658 CMe NMe Q1i a bond Me bond NH S a bond T3h OH

2659 CMe NMe Q1i a bond Me bond NH S a bond T3i OH

2660 CMe NMe Q1i a bond Me bond NH S a bond T3j OH

2661 CMe NMe Q1i a bond Me bond NH O NH T3a OH

2662 CMe NMe Q1i a bond Me bond NH O NH T3b OH

2663 CMe NMe Q1i a bond Me bond NH O NH T3c OH

2664 CMe NMe Q1i a bond Me bond NH O NH T3d OH

2665 CMe NMe Q1i a bond Me bond NH O NH T3e OH

2666 CMe NMe Q1i a bond Me bond NH O NH T3f OH

2667 CMe NMe Q1i a bond Me bond NH O NHT3g OH

2668 CMe NMe Q1i a bond Me bond NH O NH T3h OH

2669 CMe NMe Q1i a bond Me bond NH O NH T3i OH

2670 CMe NMe Q1i a bond Me bond NH O NH T3j OH

2671 CMe NMe Q1i a bond Me bond NH O a bond T3a OH

2672 CMe NMe Q1i a bond Me bond NH O a bond T3b OH

2673 CMe NMe Q1i a bond Me bond NH O a bond T3c OH

2674 CMe NMe Q1i a bond Me bond NH O a bond T3d OH

2675 CMe NMe Q1i a bond Me bond NH O a bond T3e OH

2676 CMe NMe Q1i a bond Me bond NH O a bond T3f OH

2677 CMe NMe Q1i a bond Me bond NH O a bond T3g OH

2678 CMe NMe Q1i a bond Me bond NH O a bond T3h OH

2679 CMe NMe Q1i a bond Me bond NH O a bond T3i OH

2680 CMe NMe Q1i a bond Me bond NH O a bond T3j OH

2681 CMe NMe Q1i a bond H a bond NH S NH T3a OH

2682 CMe NMe Q1i a bond H a bond NH S NH T3b OH

2683 CMe NMe Q1i a bond H a bond NH S NH T3c OH

2684 CMe NMe Q1i a bond H a bond NH S NH T3d OH

2685 CMe NMe Q1i a bond H a bond NH S NH T3e OH

2686 CMe NMe Q1i a bond H a bond NH S NH T3f OH

2687 CMe NMe Q1i a bond H a bond NH S NH T3g OH

2688 CMe NMe Q1i a bond H a bond NH S NH T3h OH

2689 CMe NMe Q1i a bond H a bond NH S NH T3i OH

2690 CMe NMe Q1i a bond H a bond NH S NH T3j OH

2691 CMe NMe Q1i a bond H a bond NH S a bond T3a OH

2692 CMe NMe Q1i a bond H a bond NH S a bond T3b OH

2693 CMe NMe Q1i a bond H a bond NH S a bond T3c OH

2694 CMe NMe Q1i a bond H a bond NH S a bond T3d OH

2695 CMe NMe Q1i a bond H a bond NH S a bond T3e OH

2696 CMe NMe Q1i a bond H a bond NH S a bond T3f OH

2697 CMe NMe Q1i a bond H a bond NH S a bond T3g OH

2698 CMe NMe Q1i a bond H a bond NH S a bond T3h OH

2699 CMe NMe Q1i a bond H a bond NH S a bond T3i OH

2700 CMe NMe Q1i a bond H a bond NH S a bond T3j OH

2701 CMe NMe Q1i a bond H a bond NH O NH T3a OH

2702 CMe NMe Q1i a bond H a bond NH O H T3b OH

2703 CMe NMe Q1i a bond H a bond NH O NH T3c OH

2704 CMe NMe Q1i a bond H a bond NH O NH T3d OH

2705 CMe NMe Q1i a bond H a bond NH O NH T3e OH

2706 CMe NMe Q1i a bond H a bond NH O NH T3f OH

2707 CMe NMe Q1i a bond H a bond NH O NH T3g OH

2708 CMe NMe Q1i a bond H a bond NH O NH T3h OH

2709 CMe NMe Q1i a bond H a bond NH O NH T3i OH

2710 CMe NMe Q1i a bond H a bond NH O NH T3j OH

2711 CMe NMe Q1i a bond H a bond NH O a bond T3a OH

2712 CMe NMe Q1i a bond H a bond NH O a bond T3b OH

2713 CMe NMe Q1i a bond H a bond NH O a bond T3c OH

2714 CMe NMe Q1i a bond H a bond NH O a bond T3d OH

2715 CMe NMe Q1i a bond H a bond NH O a bond T3e OH

2716 CMe NMe Q1i a bond H a bond NH O a bond T3f OH

2717 CMe NMe Q1i a bond H a bond NH O a bond T3g OH

2718 CMe NMe Q1i a bond H a bond NH O a bond T3h OH

2719 CMe NMe Q1i a bond H a bond NH O a bond T3i OH

2720 CMe NMe Q1i a bond H a bond NH O a bond T3j OH

2721 CMe NMe Q1j a bond Me bond NH S NH T3a OH

2722 CMe NMe Q1j a bond Me bond NH S NH T3b OH

2723 CMe NMe Q1j a bond Me bond NH S NH T3c OH

2724 CMe NMe Q1j a bond Me bond NH S NH T3d OH

2725 CMe NMe Q1j a bond Me bond NH S NH T3e OH

2726 CMe NMe Q1j a bond Me bond NH S NH T3f OH

2727 CMe NMe Q1j a bond Me bond NH S NH T3g OH

2728 CMe NMe Q1j a bond Me bond NH S NH T3h OH

2729 CMe NMe Q1j a bond Me bond NH S NH T3i OH

2730 CMe NMe Q1j a bond Me bond NH S NH T3j OH

2731 CMe NMe Q1j a bond Me bond NH S a bond T3a OH

2732 CMe NMe Q1j a bond Me bond NH S a bond T3b OH

2733 CMe NMe Q1j a bond Me bond NH S a bond T3c OH

2734 CMe NMe Q1j a bond Me bond NH S a bond T3d OH

2735 CMe NMe Q1j a bond Me bond NH S a bond T3e OH

2736 CMe NMe Q1j a bond Me bond NH S a bond T3f OH

2737 CMe NMe Q1j a bond Me bond NH S a bond T3g OH

278 CMe NMe Q1j a bond Me bond NH S a bond T3h OH

2739 CMe NMe Q1j a bond Me bond NH S a bond T3i OH

2740 CMe NMe Q1j a bond Me bond NH S a bond T3j OH

2741 CMe NMe Q1j a bond Me bond NH O NH T3a OH

2742 CMe NMe Q1j a bond Me bond NH O NH T3b OH

2743 CMe NMe Q1j a bond Me bond NH O NH T3c OH

2744 CMe NMe Q1j a bond Me bond NH O NH T3d OH

2745 CMe NMe Q1j a bond Me bond NH O NH T3e OH

2746 CMe NMe Q1j a bond Me bond NH O NH T3f OH

2747 CMe NMe Q1j a bond Me bond NH O NH T3g OH

2748 CMe NMe Q1j a bond Me bond NH O NH T3h OH

2749 CMe NMe Q1j a bond Me bond NH O NH T3i OH

2750 CMe NMe Q1j a bond Me bond NH O NH T3j OH

2751 CMe NMe Q1j a bond Me bond NH O a bond T3a OH

2752 CMe NMe Q1j a bond Me bond NH O a bond T3b OH

2753 CMe NMe Q1j a bond Me bond NH O a bond T3c OH

2754 CMe NMe Q1j a bond Me bond NH O a bond T3d OH

2755 CMe NMe Q1j a bond Me bond NH O a bond T3e OH

2756 CMe NMe Q1j a bond Me bond NH O a bond T3f OH

2757 CMe NMe Q1j a bond Me bond NH O a bond T3g OH

2758 CMe NMe Q1j a bond Me bond NH O a bond T3h OH

2759 CMe NMe Q1j a bond Me bond NH O a bond T3i OH

2760 CMe NMe Q1j a bond Me bond NH O a bond T3j OH

2761 CMe NMe Q1j a bond H a bond NH S NH T3a OH

2762 CMe NMe Q1j a bond H a bond NH S NH T3b OH

2763 CMe NMe Q1j a bond H a bond NH S NH T3c OH

2764 CMe NMe Q1j a bond H a bond NH S NH T3d OH

2765 CMe NMe Q1j a bond H a bond NH S NH T3e OH

2766 CMe NMe Q1j a bond H a bond NH S NH T3f OH

2767 CMe NMe Q1j a bond H a bond NH S NH T3g OH

2768 CMe NMe Q1j a bond H a bond NH S NH T3h OH

2769 CMe NMe Q1j a bond H a bond NH S NH T3i OH

2770 CMe NMe Q1j a bond H a bond NH S NH T3j OH

2771 CMe NMe Q1j a bond H a bond NH S a bond T3a OH

2772 CMe NMe Q1j a bond H a bond NH S a bond T3b OH

2773 CMe NMe Q1j a bond H a bond NH S a bond T3c OH

2774 CMe NMe 1j bond H a bond NH S a bond T3d OH

2775 CMe NMe Q1j a bond H a bond NH S a bond T3e OH

2776 CMe NMe Q1j a bond H a bond NH S a bond T3f OH

2777 CMe NMe Q1j a bond H a bond NH S a bond T3g OH

2778 CMe NMe Q1j a bond H a bond NH S a bond T3h OH

2779 CMe NMe Q1j a bond H a bond NH S a bond T3i OH

2780 CMe NMe Q1j a bond H a bond NH S a bond T3j OH

2781 CMe NMe Q1j a bond H a bond NH O NH T3a OH

2782 CMe NMe Q1j a bond H a bond NH O NH T3b OH

2783 CMe NMe Q1j a bond H a bond NH O NH T3c OH

2784 CMe NMe Q1j a bond H a bond NH O NH T3d OH

2785 CMe NMe Q1j a bond H a bond NH O NH T3e OH

2786 CMe NMe Q1j a bond H a bond NH O NH T3f OH

2787 CMe NMe Q1j a bond H a bond NH O NH T3g OH

2788 CMe NMe Q1j a bond H a bond NH O NH T3h OH

2789 CMe NMe Q1j a bond H a bond NH O NH T3i OH

2790 CMe NMe Q1j a bond H a bond NH O NH T3j OH

2791 CMe NMe Q1j a bond H a bond NH O a bond T3a OH

2792 CMe NMe Q1j a bond H a bond NH O a bond T3b OH

2793 CMe NMe Q1j a bond H a bond NH O a bond T3c OH

2794 CMe NMe Q1j a bond H a bond NH O a bond T3d OH

2795 CMe NMe Q1j a bond H a bond NH O a bond T3e OH

2796 CMe NMe Q1j a bond H a bond NH O a bond T3f OH

2797 CMe NMe Q1j a bond H a bond NH O a bond T3g OH

2798 CMe NMe Q1j a bond H a bond NH O a bond T3h OH

2799 CMe NMe Q1j a bond H a bond NH O a bond T3i OH

2800 CMe NMe Q1j a bond H a bond NH O a bond T3j OH

2801 CMe S Q1a a bond Me bond NH S NH T3a OH

2802 CMe S Q1a a bond Me bond NH S NH T3b OH

2803 CMe S Q1a a bond Me bond NH S NH T3c OH

2804 CMe S Q1a a bond Me bond NH S NH T3d OH

2805 CMe S Q1a a bond Me bond NH S NH T3e OH

2806 CMe S Q1a a bond Me bond NH S NH T3f OH

2807 CMe S Q1a a bond Me bond NH S NH T3g OH

2808 CMe S Q1a a bond Me bond NH S NH T3h OH

2809 CMe S Q1a a bond Me bond NH S NH T3i OH

2810 CMe S Q1a a bond Me link to the e NH S NH T3j OH

2811 CMe S Q1a a bond Me bond NH S a bond T3a OH

2812 CMe S Q1a a bond Me bond NH S a bond T3b OH

2813 CMe S Q1a a bond Me bond NH S a bond T3c OH

2814 CMe S Q1a a bond Me bond NH S a bond T3d OH

2815 CMe S Q1a a bond Me bond NH S a bond T3e OH

2816 CMe S Q1a a bond Me bond NH S a bond T3f OH

2817 CMe S Q1a a bond Me bond NH S a bond T3g OH

2818 CMe S Q1a a bond Me bond NH S a bond T3h OH

2819 CMe S Q1a a bond Me bond NH S a bond T3i OH

2820 CMe S Q1a a bond Me bond NH S a bond T3j OH

2821 CMe S Q1a a bond Me bond NH O NH T3a OH

2822 CMe S Q1a a bond Me bond NH O NH T3b OH

2823 CMe S Q1a a bond Me bond NH O NH T3c OH

2824 CMe S Q1a a bond Me bond NH O NH T3d OH

2825 CMe S Q1a a bond Me bond NH O NH T3e OH

2826 CMe S Q1a a bond Me bond NH O NH T3f OH

2827 CMe S Q1a a bond Me bond NH O NH T3g OH

2828 CMe S Q1a a bond Me bond NH O NH T3h OH

2829 CMe S Q1a a bond Me bond NH O NH T3i OH

2830 CMe S Q1a a bond Me bond NH O NH T3j OH

2831 CMe S Q1a a bond Me bond NH O a bond T3a OH

2832 CMe S Q1a a bond Me bond NH O a bond T3b OH

2833 CMe S Q1a a bond Me bond NH O a bond T3c OH

2834 CMe S Q1a a bond Me bond NH O a bond T3d OH

2835 CMe S Q1a a bond Me bond NH O a bond T3e OH

2836 CMe S Q1a a bond Me bond NH O a bond T3f OH

2837 CMe S Q1a a bond Me bond NH O a bond T3g OH

2838 CMe S Q1a a bond Me bond NH O a bond T3h OH

2839 CMe S Q1a a bond Me bond NH O a bond T3i OH

2840 CMe S Q1a a bond Me bond NH O a bond T3j OH

2841 CMe S Q1a a bond H a bond NH S NH T3a OH

2842 CMe S Q1a a bond H a bond NH S NH T3b OH

2843 CMe S Q1a a bond H a bond NH S NH T3c OH

2844 CMe S Q1a a bond H a bond NH S NH T3d OH

2845 CMe S Q1a a bond H a bond NH S NH T3e OH

2846 CMe S Q1a a bond H of light is ü NH S NH T3f OH

2847 CMe S Q1a a bond H a bond NH S NH T3g OH

2848 CMe S Q1a a bond H a bond NH S NH T3h OH

2849 CMe S Q1a a bond H a bond NH S NH T3i OH

2850 CMe S Q1a a bond H a bond NH S NH T3j OH

2851 CMe S Q1a a bond H a bond NH S a bond T3a OH

2852 CMe S Q1a a bond H a bond NH S a bond T3b OH

2853 CMe S Q1a a bond H a bond NH S a bond T3c OH

2854 CMe S Q1a a bond H a bond NH S a bond T3d OH

2855 CMe S Q1a a bond H a bond NH S a bond T3e OH

2856 CMe S Q1a a bond H a bond NH S a bond T3f OH

2857 CMe S Q1a a bond H a bond NH S a bond T3g OH

2858 CMe S Q1a a bond H a bond NH S a bond T3h OH

2859 CMe S Q1a a bond H a bond NH S a bond T3i OH

2860 CMe S Q1a a bond H a bond NH S a bond T3j OH

2861 CMe S Q1a a bond H a bond NH O NH T3a OH

2862 CMe S Q1a a bond H a bond NH O NH T3b OH

2863 CMe S Q1a a bond H a bond NH O NH T3c OH

2864 CMe S Q1a a bond H a bond NH O NH T3d OH

2865 CMe S Q1a a bond H a bond NH O NH T3e OH

2866 CMe S Q1a a bond H a bond NH O NH T3f OH

2867 CMe S Q1a a bond H a bond NH O NH T3g OH

2868 CMe S Q1a a bond H a bond NH O NH T3h OH

2869 CMe S Q1a a bond H a bond NH O NH T3i OH

2870 CMe S Q1a a bond H a bond NH O NH T3j OH

2871 CMe S Q1a a bond H a bond NH O a bond T3a OH

2872 CMe S Q1a a bond H a bond NH O a bond T3b OH

2873 CMe S Q1a a bond H a bond NH O a bond T3c OH

2874 CMe S Q1a a bond H a bond NH O a bond T3d OH

2875 CMe S Q1a a bond H a bond NH O a bond T3e OH

2876 CMe S Q1a a bond H a bond NH O a bond T3f OH

2877 CMe S Q1a a bond H a bond NH O a bond T3g OH

2878 CMe S Q1a a bond H a bond NH O a bond T3h OH

2879 CMe S Q1a a bond H a bond NH O a bond T3i OH

2880 CMe S Q1a a bond H a bond NH O a bond T3j OH

2881 CMe S Q1b a bond Me bond NH S NH T3a OH

2882 CMe S Q1b a bond Me bond NH S NH T3b OH

283 CMe S Q1b a bond Me bond NH S NH T3c OH

2884 CMe S Q1b a bond Me bond NH S NH T3d OH

2885 CMe S Q1b a bond Me bond NH S NH T3e OH

2886 CMe S Q1b a bond Me bond NH S NH T3f OH

2887 CMe S Q1b a bond Me bond NH S NH T3g OH

2888 CMe S Q1b a bond Me bond NH S NH T3h OH

2889 CMe S Q1b a bond Me bond NH S NH T3i OH

2890 CMe S Q1b a bond Me bond NH S NH T3j OH

2891 CMe S Q1b a bond Me bond NH S a bond T3a OH

2892 CMe S Q1b a bond Me bond NH S a bond T3b OH

2893 CMe S Q1b a bond Me bond NH S a bond T3c OH

2894 CMe S Q1b a bond Me bond NH S a bond T3d OH

2895 CMe S Q1b a bond Me bond NH S a bond T3e OH

2896 CMe S Q1b a bond Me bond NH S a bond T3f OH

2897 CMe S Q1b a bond Me bond NH S a bond T3g OH

2898 CMe S Q1b a bond Me bond NH S a bond T3h OH

2899 CMe S Q1b a bond Me bond NH S a bond T3i OH

2900 CMe S Q1b a bond Me bond NH S a bond T3j OH

2901 CMe S Q1b a bond Me bond NH O NH T3a OH

2902 CMe S Q1b a bond Me bond NH O NH T3b OH

2903 CMe S Q1b a bond Me bond NH O NH T3c OH

2904 CMe S Q1b a bond Me bond NH O NH T3d OH

2905 CMe S Q1b a bond Me bond NH O NH T3e OH

2906 CMe S Q1b a bond Me bond NH O NH T3f OH

2907 CMe S Q1b a bond Me bond NH O NH T3g OH

2908 CMe S Q1b a bond Me bond NH O NH T3h OH

2909 CMe S Q1b a bond Me bond NH O NH T3i OH

2910 CMe S Q1b a bond Me bond NH O NH T3j OH

2911 CMe S Q1b a bond Me bond NH O a bond T3a OH

2912 CMe S Q1b a bond Me bond NH O a bond T3b OH

2913 CMe S Q1b a bond Me bond NH O a bond T3c OH

2914 CMe S Q1b a bond Me bond NH O a bond T3d OH

2915 CMe S Q1b a bond Me bond NH O a bond T3e OH

2916 CMe S Q1b a bond Me bond NH O a bond T3f OH

2917 CMe S Q1b a bond Me bond NH O a bond T3g OH

2918 CMe S Q1b a bond Me bond NH O a bond T3h OH

2919 CMe S Q1b a bond Me bond NH O the ligature T3i OH

2920 CMe S Q1b a bond Me bond NH O a bond T3j OH

2921 CMe S Q1b a bond H a bond NH S NH T3a OH

2922 CMe S Q1b a bond H a bond NH S NH T3b OH

2923 CMe S Q1b a bond H a bond NH S NH T3c OH

2924 CMe S Q1b a bond H a bond NH S NH T3d OH

2925 CMe S Q1b a bond H a bond NH S NH T3e OH

2926 CMe S Q1b a bond H a bond NH S NH T3f OH

2927 CMe S Q1b a bond H a bond NH S NH T3g OH

2928 CMe S Q1b a bond H a bond NH S NH T3h OH

2929 CMe S Q1b a bond H a bond NH S NH T3i OH

2930 CMe S Q1b a bond H a bond NH S NH T3j OH

2931 CMe S Q1b a bond H a bond NH S a bond T3a OH

2932 CMe S Q1b a bond H a bond NH S a bond T3b OH

2933 CMe S Q1b a bond H a bond NH S a bond T3c OH

2934 CMe S Q1b a bond H a bond NH S a bond T3d OH

2935 CMe S Q1b a bond H a bond NH S a bond T3e OH

2936 CMe S Q1b a bond H a bond NH S a bond T3f OH

2937 CMe S Q1b a bond H a bond NH S a bond T3g OH

2938 CMe S Q1b a bond H a bond NH S a bond T3h OH

2939 CMe S Q1b a bond H a bond NH S a bond T3i OH

2940 CMe S Q1b a bond H a bond NH S a bond T3j OH

2941 CMe S Q1b a bond H a bond NH O NH T3a OH

2942 CMe S Q1b a bond H a bond NH O NH T3b OH

2943 CMe S Q1b a bond H a bond NH O NH T3c OH

2944 CMe S Q1b a bond H a bond NH O NH T3d OH

2945 CMe S Q1b a bond H a bond NH O NH T3e OH

2946 CMe S Q1b a bond H a bond NH O NH T3f OH

2947 CMe S Q1b a bond H a bond NH O NH T3g OH

2948 CMe S Q1b a bond H a bond NH O NH T3h OH

2949 CMe S Q1b a bond H a bond NH O NH T3i OH

2950 CMe S Q1b a bond H a bond NH O NH T3j OH

2951 CMe S Q1b a bond H a bond NH O a bond T3a OH

2952 CMe S Q1b a bond H a bond NH O a bond T3b OH

2953 CMe S Q1b a bond H a bond NH O a bond T3c OH

2954 CMe S Q1b a bond H a bond NH O a bond T3d OH

2955 CMe S Q1b a bond H a bond NH O a bond T3e OH

2956 CMe S Q1b a bond H of light is e NH O a bond T3f OH

2957 CMe S Q1b a bond H a bond NH O a bond T3g OH

2958 CMe S Q1b a bond H a bond NH O a bond T3h OH

2959 CMe S Q1b a bond H a bond NH O a bond T3i OH

2960 CMe S Q1b a bond H a bond NH O a bond T3j OH

2961 CMe S Q1c a bond Me bond NH S NH T3a OH

2962 CMe S Q1c a bond Me bond NH S NH T3b OH

2963 CMe S Q1c a bond Me bond NH S NH T3c OH

2964 CMe S Q1c a bond Me bond NH S NH T3d OH

2965 CMe S Q1c a bond Me bond NH S NH T3e OH

2966 CMe S Q1c a bond Me bond NH S NH T3f OH

2967 CMe S Q1c a bond Me bond NH S NH T3g OH

2968 CMe S Q1c a bond Me bond NH S NH T3h OH

2969 CMe S Q1c a bond Me bond NH S NH T3i OH

2970 CMe S Q1c a bond Me bond NH S NH T3j OH

2971 CMe S Q1c a bond Me bond NH S a bond T3a OH

2972 CMe S Q1c a bond Me bond NH S a bond T3b OH

2973 CMe S Q1c a bond Me bond NH S a bond T3c OH

2974 CMe S Q1c a bond Me bond NH S a bond T3d OH

2975 CMe S Q1c a bond Me bond NH S a bond T3e OH

2976 CMe S Q1c a bond Me bond NH S a bond T3f OH

2977 CMe S Q1c a bond Me bond NH S a bond T3g OH

2978 CMe S Q1c a bond Me bond NH S a bond T3h OH

2979 CMe S Q1c a bond Me bond NH S a bond T3i OH

2980 CMe S Q1c a bond Me bond NH S a bond T3j OH

2981 CMe S Q1c a bond Me bond NH O NH T3a OH

2982 CMe S Q1c a bond Me bond NH O NH T3b OH

2983 CMe S Q1c a bond Me bond NH O NH T3c OH

2984 CMe S Q1c a bond Me bond NH O NH T3d OH

2985 CMe S Q1c a bond Me bond NH O NH T3e OH

2986 CMe S Q1c a bond Me bond NH O NH T3f OH

2987 CMe S Q1c a bond Me bond NH O NH T3g OH

2988 CMe S Q1c a bond Me bond NH O NH T3h OH

2989 CMe S Q1c a bond Me bond NH O NH T3i OH

2990 CMe S Q1c a bond Me bond NH O NH T3j OH

2991 CMe S Q1c a bond Me bond NH O a bond T3a OH

2992 CMe S Q1c a bond Me bond NH O a bond T3b OH

299 CMe S Q1c a bond Me bond NH O a bond T3c OH

2994 CMe S Q1c a bond Me bond NH O a bond T3d OH

2995 CMe S Q1c a bond Me bond NH O a bond T3e OH

2996 CMe S Q1c a bond Me bond NH O a bond T3f OH

2997 CMe S Q1c a bond Me bond NH O a bond T3g OH

2998 CMe S Q1c a bond Me bond NH O a bond T3h OH

2999 CMe S Q1c a bond Me bond NH O a bond T3i OH

3000 CMe S Q1c a bond Me bond NH O a bond T3j OH

3001 CMe S Q1c a bond H a bond NH S NH T3a OH

3002 CMe S Q1c a bond H a bond NH S NH T3b OH

3003 CMe S Q1c a bond H a bond NH S NH T3c OH

3004 CMe S Q1c a bond H a bond NH S NH T3d OH

3005 CMe S Q1c a bond H a bond NH S NH T3e OH

3006 CMe S Q1c a bond H a bond NH S NH T3f OH

3007 CMe S Q1c a bond H a bond NH S NH T3g OH

3008 CMe S Q1c a bond H a bond NH S NH T3h OH

3009 CMe S Q1c a bond H a bond NH S NH T3i OH

3010 CMe S Q1c a bond H a bond NH S NH T3j OH

3011 CMe S Q1c a bond H a bond NH S a bond T3a OH

3012 CMe S Q1c a bond H a bond NH S a bond T3b OH

3013 CMe S Q1c a bond H a bond NH S a bond T3c OH

3014 CMe S Q1c a bond H a bond NH S a bond T3d OH

3015 CMe S Q1c a bond H a bond NH S a bond T3e OH

3016 CMe S Q1c a bond H a bond NH S a bond T3f OH

3017 CMe S Q1c a bond H a bond NH S a bond T3g OH

3018 CMe S Q1c a bond H a bond NH S a bond T3h OH

3019 CMe S Q1c a bond H a bond NH S a bond T3i OH

3020 CMe S Q1c a bond H a bond NH S a bond T3j OH

3021 CMe S Q1c a bond H a bond NH O NH T3a OH

3022 CMe S Q1c a bond H a bond NH O NH T3b OH

3023 CMe S Q1c a bond H a bond NH O NH T3c OH

3024 CMe S Q1c a bond H a bond NH O NH T3d OH

3025 CMe S Q1c a bond H a bond NH O NH T3e OH

3026 CMe S Q1c a bond H a bond NH O NH T3f OH

3027 CMe S Q1c a bond H a bond NH O NH T3g OH

3028 CMe S Q1c a bond H a bond NH O NH T3h OH

3029 CMe S Q1c a bond H a bond NH O NH T3i OH

3030 CMe S Q1c St is z H a bond NH O NH T3j OH

3031 CMe S Q1c a bond H a bond NH O a bond T3a OH

3032 CMe S Q1c a bond H a bond NH O a bond T3b OH

3033 CMe S Q1c a bond H a bond NH O a bond T3c OH

3034 CMe S Q1c a bond H a bond NH O a bond T3d OH

3035 CMe S Q1c a bond H a bond NH O a bond T3e OH

3036 CMe S Q1c a bond H a bond NH O a bond T3f OH

3037 CMe S Q1c a bond H a bond NH O a bond T3g OH

3038 CMe S Q1c a bond H a bond NH O a bond T3h OH

3039 CMe S Q1c a bond H a bond NH O a bond T3i OH

3040 CMe S Q1c a bond H a bond NH O a bond T3j OH

3041 CMe S Q1i a bond Me bond NH S NH T3a OH

3042 CMe S Q1i a bond Me bond NH S NH T3b OH

3043 CMe S Q1i a bond Me bond NH S NH T3c OH

3044 CMe S Q1i a bond Me bond NH S NH T3d OH

3045 CMe S Q1i a bond Me bond NH S NH T3e OH

3046 CMe S Q1i a bond Me bond NH S NH T3f OH

3047 CMe S Q1i a bond Me bond NH S NH T3g OH

3048 CMe S Q1i a bond Me bond NH S NH T3h OH

3049 CMe S Q1i a bond Me bond NH S NH T3i OH

3050 CMe S Q1i a bond Me bond NH S NH T3j OH

3051 CMe S Q1i a bond Me bond NH S a bond T3a OH

3052 CMe S Q1i a bond Me bond NH S a bond T3b OH

3053 CMe S Q1i a bond Me bond NH S a bond T3c OH

3054 CMe S Q1i a bond Me bond NH S a bond T3d OH

3055 CMe S Q1i a bond Me bond NH S a bond T3e OH

3056 CMe S Q1i a bond Me bond NH S a bond T3f OH

3057 CMe S Q1i a bond Me bond NH S a bond T3g OH

3058 CMe S Q1i a bond Me bond NH S a bond T3h OH

3059 CMe S Q1i a bond Me bond NH S a bond T3i OH

3060 CMe S Q1i a bond Me bond NH S a bond T3j OH

3061 CMe S Q1i a bond Me bond NH O NH T3a OH

3062 CMe S Q1i a bond Me bond NH O NH T3b OH

3063 CMe S Q1i a bond Me bond NH O NH T3c OH

3064 CMe S Q1i a bond Me bond NH O NH T3d OH

3065 CMe S Q1i a bond Me bond NH O NH T3e OH

3066 CMe S Q1i a bond Me bond H O NH T3f OH

3067 CMe S Q1i a bond Me bond NH O NH T3g OH

3068 CMe S Q1i a bond Me bond NH O NH T3h OH

3069 CMe S Q1i a bond Me bond NH O NH T3i OH

3070 CMe S Q1i a bond Me bond NH O NH T3j OH

3071 CMe S Q1i a bond Me bond NH O a bond T3a OH

3072 CMe S Q1i a bond Me bond NH O a bond T3b OH

3073 CMe S Q1i a bond Me bond NH O a bond T3c OH

3074 CMe S Q1i a bond Me bond NH O a bond T3d OH

3075 CMe S Q1i a bond Me bond NH O a bond T3e OH

3076 CMe S Q1i a bond Me bond NH O a bond T3f OH

3077 CMe S Q1i a bond Me bond NH O a bond T3g OH

3078 CMe S Q1i a bond Me bond NH O a bond T3h OH

3079 CMe S Q1i a bond Me bond NH O a bond T3i OH

3080 CMe S Q1i a bond Me bond NH O a bond T3j OH

3081 CMe S Q1i a bond H a bond NH S NH T3a OH

3082 CMe S Q1i a bond H a bond NH S NH T3b OH

3083 CMe S Q1i a bond H a bond NH S NH T3c OH

3084 CMe S Q1i a bond H a bond NH S NH T3d OH

3085 CMe S Q1i a bond H a bond NH S NH T3e OH

3086 CMe S Q1i a bond H a bond NH S NH T3f OH

3087 CMe S Q1i a bond H a bond NH S NH T3g OH

3088 CMe S Q1i a bond H a bond NH S NH T3h OH

3089 CMe S Q1i a bond H a bond NH S NH T3i OH

3090 CMe S Q1i a bond H a bond NH S NH T3j OH

3091 CMe S Q1i a bond H a bond NH S a bond T3a OH

3092 CMe S Q1i a bond H a bond NH S a bond T3b OH

3093 CMe S Q1i a bond H a bond NH S a bond T3c OH

3094 CMe S Q1i a bond H a bond NH S a bond T3d OH

3095 CMe S Q1i a bond H a bond NH S a bond T3e OH

3096 CMe S Q1i a bond H a bond NH S a bond T3f OH

3097 CMe S Q1i a bond H a bond NH S a bond T3g OH

3098 CMe S Q1i a bond H a bond NH S a bond T3h OH

3099 CMe S Q1i a bond H a bond NH S a bond T3i OH

3100 CMe S Q1i a bond H a bond NH S a bond T3j OH

3101 CMe S Q1i a bond H a bond NH O NH T3a OH

3102 CMe S Q1i a bond H a bond NH O NH T3b H

3103 CMe S Q1i a bond H a bond NH O NH T3c OH

3104 CMe S Q1i a bond H a bond NH O NH T3d OH

3105 CMe S Q1i a bond H a bond NH O NH T3e OH

3106 CMe S Q1i a bond H a bond NH O NH T3f OH

3107 CMe S Q1i a bond H a bond NH O NH T3g OH

3108 CMe S Q1i a bond H a bond NH O NH T3h OH

3109 CMe S Q1i a bond H a bond NH O NH T3i OH

3110 CMe S Q1i a bond H a bond NH O NH T3j OH

3111 CMe S Q1i a bond H a bond NH O a bond T3a OH

3112 CMe S Q1i a bond H a bond NH O a bond T3b OH

3113 CMe S Q1i a bond H a bond NH O a bond T3c OH

3114 CMe S Q1i a bond H a bond NH O a bond T3d OH

3115 CMe S Q1i a bond H a bond NH O a bond T3e OH

3116 CMe S Q1i a bond H a bond NH O a bond T3f OH

3117 CMe S Q1i a bond H a bond NH O a bond T3g OH

3118 CMe S Q1i a bond H a bond NH O a bond T3h OH

3119 CMe S Q1i a bond H a bond NH O a bond T3i OH

3120 CMe S Q1i a bond H a bond NH O a bond T3j OH

3121 CMe S Q1j a bond Me bond NH S NH T3a OH

3122 CMe S Q1j a bond Me bond NH S NH T3b OH

3123 CMe S Q1j a bond Me bond NH S NH T3c OH

3124 CMe S Q1j a bond Me bond NH S NH T3d OH

3125 CMe S Q1j a bond Me bond NH S NH T3e OH

3126 CMe S Q1j a bond Me bond NH S NH T3f OH

3127 CMe S Q1j a bond Me bond NH S NH T3g OH

3128 CMe S Q1j a bond Me bond NH S NH T3h OH

3129 CMe S Q1j a bond Me bond NH S NH T3i OH

3130 CMe S Q1j a bond Me bond NH S NH T3j OH

3131 CMe S Q1j a bond Me bond NH S a bond T3a OH

3132 CMe S Q1j a bond Me bond NH S a bond T3b OH

3133 CMe S Q1j a bond Me bond NH S a bond T3c OH

3134 CMe S Q1j a bond Me bond NH S a bond T3d OH

3135 CMe S Q1j a bond Me bond NH S a bond T3e OH

3136 CMe S Q1j a bond Me bond NH S a bond T3f OH

at 3,137 CMe S Q1j a bond Me bond NH S a bond T3g OH

3138 CMe S Q1j a bond Me bond NH S a bond T3h OH

339 CMe S Q1j a bond Me bond NH S a bond T3i OH

3140 CMe S Q1j a bond Me bond NH S a bond T3j OH

3141 CMe S Q1j a bond Me bond NH O NH T3a OH

3142 CMe S Q1j a bond Me bond NH O NH T3b OH

3143 CMe S Q1j a bond Me bond NH O NH T3c OH

3144 CMe S Q1j a bond Me bond NH O NH T3d OH

3145 CMe S Q1j a bond Me bond NH O NH T3e OH

3146 CMe S Q1j a bond Me bond NH O NH T3f OH

3147 CMe S Q1j a bond Me bond NH O NH T3g OH

3148 CMe S Q1j a bond Me bond NH O NH T3h OH

3149 CMe S Q1j a bond Me bond NH O NH T3i OH

3150 CMe S Q1j a bond Me bond NH O NH T3j OH

3151 CMe S Q1j a bond Me bond NH O a bond T3a OH

3152 CMe S Q1j a bond Me bond NH O a bond T3b OH

3153 CMe S Q1j a bond Me bond NH O a bond T3c OH

3154 CMe S Q1j a bond Me bond NH O a bond T3d OH

3155 CMe S Q1j a bond Me bond NH O a bond T3e OH

3156 CMe S Q1j a bond Me bond NH O a bond T3f OH

3157 CMe S Q1j a bond Me bond NH O a bond T3g OH

3158 CMe S Q1j a bond Me bond NH O a bond T3h OH

3159 CMe S Q1j a bond Me bond NH O a bond T3i OH

3160 CMe S Q1j a bond Me bond NH O a bond T3j OH

3161 CMe S Q1j a bond H a bond NH S NH T3a OH

3162 CMe S Q1j a bond H a bond NH S NH T3b OH

3163 CMe S Q1j a bond H a bond NH S NH T3c OH

3164 CMe S Q1j a bond H a bond NH S NH T3d OH

3165 CMe S Q1j a bond H a bond NH S NH T3e OH

3166 CMe S Q1j a bond H a bond NH S NH T3f OH

3167 CMe S Q1j a bond H a bond NH S NH T3g OH

3168 CMe S Q1j a bond H a bond NH S NH T3h OH

3169 CMe S Q1j a bond H a bond NH S NH T3i OH

3170 CMe S Q1j a bond H a bond NH S NH T3j OH

3171 CMe S Q1j a bond H a bond NH S a bond T3a OH

3172 CMe S Q1j a bond H a bond NH S a bond T3b OH

3173 CMe S Q1j a bond H a bond NH S a bond T3c OH

3174 CMe S Q1j a bond H a bond NH S a bond T3d OH

3175 CMe S Q1j a bond H a bond NH S a bond T3e OH

3176 CMe's Q1j H a bond NH S a bond T3f OH

3177 CMe S Q1j a bond H a bond NH S a bond T3g OH

3178 CMe S Q1j a bond H a bond NH S a bond T3h OH

3179 CMe S Q1j a bond H a bond NH S a bond T3i OH

3180 CMe S Q1j a bond H a bond NH S a bond T3j OH

3181 CMe S Q1j a bond H a bond NH O NH T3a OH

3182 CMe S Q1j a bond H a bond NH O NH T3b OH

3183 CMe S Q1j a bond H a bond NH O NH T3c OH

3184 CMe S Q1j a bond H a bond NH O NH T3d OH

3185 CMe S Q1j a bond H a bond NH O NH T3e OH

3186 CMe S Q1j a bond H a bond NH O NH T3f OH

3187 CMe S Q1j a bond H a bond NH O NH T3g OH

3188 CMe S Q1j a bond H a bond NH O NH T3h OH

3189 CMe S Q1j a bond H a bond NH O NH T3i OH

3190 CMe S Q1j a bond H a bond NH O NH T3j OH

3191 CMe S Q1j a bond H a bond NH O a bond T3a OH

3192 CMe S Q1j a bond H a bond NH O a bond T3b OH

3193 CMe S Q1j a bond H a bond NH O a bond T3c OH

3194 CMe S Q1j a bond H a bond NH O a bond T3d OH

3195 CMe S Q1j a bond H a bond NH O a bond T3e OH

3196 CMe S Q1j a bond H a bond NH O a bond T3f OH

3197 CMe S Q1j a bond H a bond NH O a bond T3g OH

3198 CMe S Q1j a bond H a bond NH O a bond T3h OH

3199 CMe S Q1j a bond H a bond NH O a bond T3i OH

3200 CMe S Q1j a bond H a bond NH O a bond T3j OH

3201 CMe O Q1a a bond Me bond NH S NH T3a OH

3202 CMe O Q1a a bond Me bond NH S NH T3b OH

3203 CMe O Q1a a bond Me bond NH S NH T3c OH

3204 CMe O Q1a a bond Me bond NH S NH T3d OH

3205 CMe O Q1a a bond Me bond NH S NH T3e OH

3206 CMe O Q1a a bond Me bond NH S NH T3f OH

3207 CMe O Q1a a bond Me bond NH S NH T3g OH

3208 CMe O Q1a a bond Me bond NH S NH T3h OH

3209 CMe O Q1a a bond Me bond NH S NH T3i OH

3210 CMe O Q1a a bond Me bond NH S NH T3j OH

3211 CMe O Q1a a bond Me bond NH S a bond T3a OH

3212 CMe O Q1a a bond Me bond NH S a bond T3b OH

3213 CMe O Q1a tie is Me bond NH S a bond T3c OH

3214 CMe O Q1a a bond Me bond NH S a bond T3d OH

3215 CMe O Q1a a bond Me bond NH S a bond T3e OH

3216 CMe O Q1a a bond Me bond NH S a bond T3f OH

3217 CMe O Q1a a bond Me bond NH S a bond T3g OH

3218 CMe O Q1a a bond Me bond NH S a bond T3h OH

3219 CMe O Q1a a bond Me bond NH S a bond T3i OH

3220 CMe O Q1a a bond Me bond NH S a bond T3j OH

3221 CMe O Q1a a bond Me bond NH O NH T3a OH

3222 CMe O Q1a a bond Me bond NH O NH T3b OH

3223 CMe O Q1a a bond Me bond NH O NH T3c OH

3224 CMe O Q1a a bond Me bond NH O NH T3d OH

3225 CMe O Q1a a bond Me bond NH O NH T3e OH

3226 CMe O Q1a a bond Me bond NH O NH T3f OH

3227 CMe O Q1a a bond Me bond NH O NH T3g OH

3228 CMe O Q1a a bond Me bond NH O NH T3h OH

3229 CMe O Q1a a bond Me bond NH O NH T3i OH

3230 CMe O Q1a a bond Me bond NH O NH T3j OH

3231 CMe O Q1a a bond Me bond NH O a bond T3a OH

3232 CMe O Q1a a bond Me bond NH O a bond T3b OH

3233 CMe O Q1a a bond Me bond NH O a bond T3c OH

3234 CMe O Q1a a bond Me bond NH O a bond T3d OH

3235 CMe O Q1a a bond Me bond NH O a bond T3e OH

3236 CMe O Q1a a bond Me bond NH O a bond T3f OH

3237 CMe O Q1a a bond Me bond NH O a bond T3g OH

3238 CMe O Q1a a bond Me bond NH O a bond T3h OH

3239 CMe O Q1a a bond Me bond NH O a bond T3i OH

3240 CMe O Q1a a bond Me bond NH O a bond T3j OH

3241 CMe O Q1a a bond H a bond NH S NH T3a OH

3242 CMe O Q1a a bond H a bond NH S NH T3b OH

3243 CMe O Q1a a bond H a bond NH S NH T3c OH

3244 CMe O Q1a a bond H a bond NH S NH T3d OH

3245 CMe O Q1a a bond H a bond NH S NH T3e OH

3246 CMe O Q1a a bond H a bond NH S NH T3f OH

3247 CMe O Q1a a bond H a bond NH S NH T3g OH

3248 CMe O Q1a a bond H a bond NH S NH T3h OH

3249 CMe O Q1a a bond H a bond NH S NH T3i OH

250 CMe O Q1a a bond H a bond NH S NH T3j OH

3251 CMe O Q1a a bond H a bond NH S a bond T3a OH

3252 CMe O Q1a a bond H a bond NH S a bond T3b OH

3253 CMe O Q1a a bond H a bond NH S a bond T3c OH

3254 CMe O Q1a a bond H a bond NH S a bond T3d OH

3255 CMe O Q1a a bond H a bond NH S a bond T3e OH

3256 CMe O Q1a a bond H a bond NH S a bond T3f OH

3257 CMe O Q1a a bond H a bond NH S a bond T3g OH

3258 CMe O Q1a a bond H a bond NH S a bond T3h OH

3259 CMe O Q1a a bond H a bond NH S a bond T3i OH

3260 CMe O Q1a a bond H a bond NH S a bond T3j OH

3261 CMe O Q1a a bond H a bond NH O NH T3a OH

3262 CMe O Q1a a bond H a bond NH O NH T3b OH

3263 CMe O Q1a a bond H a bond NH O NH T3c OH

3264 CMe O Q1a a bond H a bond NH O NH T3d OH

3265 CMe O Q1a a bond H a bond NH O NH T3e OH

3266 CMe O Q1a a bond H a bond NH O NH T3f OH

3267 CMe O Q1a a bond H a bond NH O NH T3g OH

3268 CMe O Q1a a bond H a bond NH O NH T3h OH

3269 CMe O Q1a a bond H a bond NH O NH T3i OH

3270 CMe O Q1a a bond H a bond NH O NH T3j OH

3271 CMe O Q1a a bond H a bond NH O a bond T3a OH

3272 CMe O Q1a a bond H a bond NH O a bond T3b OH

3273 CMe O Q1a a bond H a bond NH O a bond T3c OH

3274 CMe O Q1a a bond H a bond NH O a bond T3d OH

3275 CMe O Q1a a bond H a bond NH O a bond T3e OH

3276 CMe O Q1a a bond H a bond NH O a bond T3f OH

3277 CMe O Q1a a bond H a bond NH O a bond T3g OH

3278 CMe O Q1a a bond H a bond NH O a bond T3h OH

3279 CMe O Q1a a bond H a bond NH O a bond T3i OH

3280 CMe O Q1a a bond H a bond NH O a bond T3j OH

3281 CMe O Q1b a bond Me bond NH S NH T3a OH

3282 CMe O Q1b a bond Me bond NH S NH T3b OH

3283 CMe O Q1b a bond Me bond NH S NH T3c OH

3284 CMe O Q1b a bond Me bond NH S NH T3d OH

3285 CMe O Q1b a bond Me bond NH S NH T3e OH

3286 CMe O Q1b a bond Me bond NH S NH T3f OH

<> 3287 CMe O Q1b a bond Me bond NH S NH T3g OH

3288 CMe O Q1b a bond Me bond NH S NH T3h OH

3289 CMe O Q1b a bond Me bond NH S NH T3i OH

3290 CMe O Q1b a bond Me bond NH S NH T3j OH

3291 CMe O Q1b a bond Me bond NH S a bond T3a OH

3292 CMe O Q1b a bond Me bond NH S a bond T3b OH

3293 CMe O Q1b a bond Me bond NH S a bond T3c OH

3294 CMe O Q1b a bond Me bond NH S a bond T3d OH

3295 CMe O Q1b a bond Me bond NH S a bond T3e OH

3296 CMe O Q1b a bond Me bond NH S a bond T3f OH

3297 CMe O Q1b a bond Me bond NH S a bond T3g OH

3298 CMe O Q1b a bond Me bond NH S a bond T3h OH

3299 CMe O Q1b a bond Me bond NH S a bond T3i OH

3300 CMe O Q1b a bond Me bond NH S a bond T3j OH

3301 CMe O Q1b a bond Me bond NH O NH T3a OH

3302 CMe O Q1b a bond Me bond NH O NH T3b OH

3303 CMe O Q1b a bond Me bond NH O NH T3c OH

3304 CMe O Q1b a bond Me bond NH O NH T3d OH

3305 CMe O Q1b a bond Me bond NH O NH T3e OH

3306 CMe O Q1b a bond Me bond NH O NH T3f OH

3307 CMe O Q1b a bond Me bond NH O NH T3g OH

3308 CMe O Q1b a bond Me bond NH O NH T3h OH

3309 CMe O Q1b a bond Me bond NH O NH T3i OH

3310 CMe O Q1b a bond Me bond NH O NH T3j OH

3311 CMe O Q1b a bond Me bond NH O a bond T3a OH

3312 CMe O Q1b a bond Me bond NH O a bond T3b OH

3313 CMe O Q1b a bond Me bond NH O a bond T3c OH

3314 CMe O Q1b a bond Me bond NH O a bond T3d OH

3315 CMe O Q1b a bond Me bond NH O a bond T3e OH

3316 CMe O Q1b a bond Me bond NH O a bond T3f OH

3317 CMe O Q1b a bond Me bond NH O a bond T3g OH

3318 CMe O Q1b a bond Me bond NH O a bond T3h OH

3319 CMe O Q1b a bond Me bond NH O a bond T3i OH

3320 CMe O Q1b a bond Me bond NH O a bond T3j OH

3321 CMe O Q1b a bond H a bond NH S NH T3a OH

3322 CMe O Q1b a bond H tie the NH S NH T3b OH

3323 CMe O Q1b a bond H a bond NH S NH T3c OH

3324 CMe O Q1b a bond H a bond NH S NH T3d OH

3325 CMe O Q1b a bond H a bond NH S NH T3e OH

3326 CMe O Q1b a bond H a bond NH S NH T3f OH

3327 CMe O Q1b a bond H a bond NH S NH T3g OH

3328 CMe O Q1b a bond H a bond NH S NH T3h OH

3329 CMe O Q1b a bond H a bond NH S NH T3i OH

3330 CMe O Q1b a bond H a bond NH S NH T3j OH

3331 CMe O Q1b a bond H a bond NH S a bond T3a OH

3332 CMe O Q1b a bond H a bond NH S a bond T3b OH

3333 CMe O Q1b a bond H a bond NH S a bond T3c OH

3334 CMe O Q1b a bond H a bond NH S a bond T3d OH

3335 CMe O Q1b a bond H a bond NH S a bond T3e OH

3336 CMe O Q1b a bond H a bond NH S a bond T3f OH

3337 CMe O Q1b a bond H a bond NH S a bond T3g OH

3338 CMe O Q1b a bond H a bond NH S a bond T3h OH

3339 CMe O Q1b a bond H a bond NH S a bond T3i OH

3340 CMe O Q1b a bond H a bond NH S a bond T3j OH

3341 CMe O Q1b a bond H a bond NH O NH T3a OH

3342 CMe O Q1b a bond H a bond NH O NH T3b OH

3343 CMe O Q1b a bond H a bond NH O NH T3c OH

3344 CMe O Q1b a bond H a bond NH O NH T3d OH

3345 CMe O Q1b a bond H a bond NH O NH T3e OH

3346 CMe O Q1b a bond H a bond NH O NH T3f OH

3347 CMe O Q1b a bond H a bond NH O NH T3g OH

3348 CMe O Q1b a bond H a bond NH O NH T3h OH

3349 CMe O Q1b a bond H a bond NH O NH T3i OH

3350 CMe O Q1b a bond H a bond NH O NH T3j OH

3351 CMe O Q1b a bond H a bond NH O a bond T3a OH

3352 CMe O Q1b a bond H a bond NH O a bond T3b OH

3353 CMe O Q1b a bond H a bond NH O a bond T3c OH

3354 CMe O Q1b a bond H a bond NH O a bond T3d OH

3355 CMe O Q1b a bond H a bond NH O a bond T3e OH

3356 CMe O Q1b a bond H a bond NH O a bond T3f OH

3357 CMe O Q1b a bond H a bond NH O a bond T3g OH

3358 CMe O Q1b a bond H a bond NH O a bond T3h OH

3359 CMe O Q1b St is z H a bond NH O a bond T3i OH

3360 CMe O Q1b a bond H a bond NH O a bond T3j OH

3361 CMe O Q1c a bond Me bond NH S NH T3a OH

3362 CMe O Q1c a bond Me bond NH S NH T3b OH

3363 CMe O Q1c a bond Me bond NH S NH T3c OH

3364 CMe O Q1c a bond Me bond NH S NH T3d OH

3365 CMe O Q1c a bond Me bond NH S NH T3e OH

3366 CMe O Q1c a bond Me bond NH S NH T3f OH

3367 CMe O Q1c a bond Me bond NH S NH T3g OH

3368 CMe O Q1c a bond Me bond NH S NH T3h OH

3369 CMe O Q1c a bond Me bond NH S NH T3i OH

3370 CMe O Q1c a bond Me bond NH S NH T3j OH

3371 CMe O Q1c a bond Me bond NH S a bond T3a OH

3372 CMe O Q1c a bond Me bond NH S a bond T3b OH

3373 CMe O Q1c a bond Me bond NH S a bond T3c OH

3374 CMe O Q1c a bond Me bond NH S a bond T3d OH

3375 CMe O Q1c a bond Me bond NH S a bond T3e OH

3376 CMe O Q1c a bond Me bond NH S a bond T3f OH

3377 CMe O Q1c a bond Me bond NH S a bond T3g OH

3378 CMe O Q1c a bond Me bond NH S a bond T3h OH

3379 CMe O Q1c a bond Me bond NH S a bond T3i OH

3380 CMe O Q1c a bond Me bond NH S a bond T3j OH

3381 CMe O Q1c a bond Me bond NH O NH T3a OH

3382 CMe O Q1c a bond Me bond NH O NH T3b OH

3383 CMe O Q1c a bond Me bond NH O NH T3c OH

3384 CMe O Q1c a bond Me bond NH O NH T3d OH

3385 CMe O Q1c a bond Me bond NH O NH T3e OH

3386 CMe O Q1c a bond Me bond NH O NH T3f OH

3387 CMe O Q1c a bond Me bond NH O NH T3g OH

3388 CMe O Q1c a bond Me bond NH O NH T3h OH

3389 CMe O Q1c a bond Me bond NH O NH T3i OH

3390 CMe O Q1c a bond Me bond NH O NH T3j OH

3391 CMe O Q1c a bond Me bond NH O a bond T3a OH

3392 CMe O Q1c a bond Me bond NH O a bond T3b OH

3393 CMe O Q1c a bond Me bond NH O a bond T3c OH

3394 CMe O Q1c a bond Me bond NH O a bond T3d OH

3395 CMe O Q1c a bond Me bond NH O a bond T3e OH

396 CMe O Q1c a bond Me bond NH O a bond T3f OH

3397 CMe O Q1c a bond Me bond NH O a bond T3g OH

3398 CMe O Q1c a bond Me bond NH O a bond T3h OH

3399 CMe O Q1c a bond Me bond NH O a bond T3i OH

3400 CMe O Q1c a bond Me bond NH O a bond T3j OH

3401 CMe O Q1c a bond H a bond NH S NH T3a OH

3402 CMe O Q1c a bond H a bond NH S NH T3b OH

3403 CMe O Q1c a bond H a bond NH S NH T3c OH

3404 CMe O Q1c a bond H a bond NH S NH T3d OH

3405 CMe O Q1c a bond H a bond NH S NH T3e OH

3406 CMe O Q1c a bond H a bond NH S NH T3f OH

3407 CMe O Q1c a bond H a bond NH S NH T3g OH

3408 CMe O Q1c a bond H a bond NH S NH T3h OH

3409 CMe O Q1c a bond H a bond NH S NH T3i OH

3410 CMe O Q1c a bond H a bond NH S NH T3j OH

3411 CMe O Q1c a bond H a bond NH S a bond T3a OH

3412 CMe O Q1c a bond H a bond NH S a bond T3b OH

3413 CMe O Q1c a bond H a bond NH S a bond T3c OH

3414 CMe O Q1c a bond H a bond NH S a bond T3d OH

3415 CMe O Q1c a bond H a bond NH S a bond T3e OH

3416 CMe O Q1c a bond H a bond NH S a bond T3f OH

3417 CMe O Q1c a bond H a bond NH S a bond T3g OH

3418 CMe O Q1c a bond H a bond NH S a bond T3h OH

3419 CMe O Q1c a bond H a bond NH S a bond T3i OH

3420 CMe O Q1c a bond H a bond NH S a bond T3j OH

3421 CMe O Q1c a bond H a bond NH O NH T3a OH

3422 CMe O Q1c a bond H a bond NH O NH T3b OH

3423 CMe O Q1c a bond H a bond NH O NH T3c OH

3424 CMe O Q1c a bond H a bond NH O NH T3d OH

3425 CMe O Q1c a bond H a bond NH O NH T3e OH

3426 CMe O Q1c a bond H a bond NH O NH T3f OH

3427 CMe O Q1c a bond H a bond NH O NH T3g OH

3428 CMe O Q1c a bond H a bond NH O NH T3h OH

3429 CMe O Q1c a bond H a bond NH O NH T3i OH

3430 CMe O Q1c a bond H a bond NH O NH T3j OH

3431 CMe O Q1c a bond H a bond NH O a bond T3a OH

3432 CMe O Q1c a bond H a bond NH O a bond T3b OH

3433 CMe O Q1c a bond H with the IDE NH O a bond T3c OH

3434 CMe O Q1c a bond H a bond NH O a bond T3d OH

3435 CMe O Q1c a bond H a bond NH O a bond T3e OH

3436 CMe O Q1c a bond H a bond NH O a bond T3f OH

3437 CMe O Q1c a bond H a bond NH O a bond T3g OH

3438 CMe O Q1c a bond H a bond NH O a bond T3h OH

3439 CMe O Q1c a bond H a bond NH O a bond T3i OH

3440 CMe O Q1c a bond H a bond NH O a bond T3j OH

3441 CMe O Q1i a bond Me bond NH S NH T3a OH

3442 CMe O Q1i a bond Me bond NH S NH T3b OH

3443 CMe O Q1i a bond Me bond NH S NH T3c OH

3444 CMe O Q1i a bond Me bond NH S NH T3d OH

3445 CMe O Q1i a bond Me bond NH S NH T3e OH

3446 CMe O Q1i a bond Me bond NH S NH T3f OH

3447 CMe O Q1i a bond Me bond NH S NH T3g OH

3448 CMe O Q1i a bond Me bond NH S NH T3h OH

3449 CMe O Q1i a bond Me bond NH S NH T3i OH

3450 CMe O Q1i a bond Me bond NH S NH T3j OH

3451 CMe O Q1i a bond Me bond NH S a bond T3a OH

3452 CMe O Q1i a bond Me bond NH S a bond T3b OH

3453 CMe O Q1i a bond Me bond NH S a bond T3c OH

3454 CMe O Q1i a bond Me bond NH S a bond T3d OH

3455 CMe O Q1i a bond Me bond NH S a bond T3e OH

3456 CMe O Q1i a bond Me bond NH S a bond T3f OH

3457 CMe O Q1i a bond Me bond NH S a bond T3g OH

3458 CMe O Q1i a bond Me bond NH S a bond T3h OH

3459 CMe O Q1i a bond Me bond NH S a bond T3i OH

3460 CMe O Q1i a bond Me bond NH S a bond T3j OH

3461 CMe O Q1i a bond Me bond NH O NH T3a OH

3462 CMe O Q1i a bond Me bond NH O NH T3b OH

3463 CMe O Q1i a bond Me bond NH O NH T3c OH

3464 CMe O Q1i a bond Me bond NH O NH T3d OH

3465 CMe O Q1i a bond Me bond NH O NH T3e OH

3466 CMe O Q1i a bond Me bond NH O NH T3f OH

3467 CMe O Q1i a bond Me bond NH O NH T3g OH

3468 CMe O Q1i a bond Me bond NH O NH T3h OH

3469 CMe O Q1i a bond Me bond NH O NH T3i OH

3471 CMe O Q1i a bond Me bond NH O a bond T3a OH

3472 CMe O Q1i a bond Me bond NH O a bond T3b OH

3473 CMe O Q1i a bond Me bond NH O a bond T3c OH

3474 CMe O Q1i a bond Me bond NH O a bond T3d OH

3475 CMe O Q1i a bond Me bond NH O a bond T3e OH

3476 CMe O Q1i a bond Me bond NH O a bond T3f OH

3477 CMe O Q1i a bond Me bond NH O a bond T3g OH

3478 CMe O Q1i a bond Me bond NH O a bond T3h OH

3479 CMe O Q1i a bond Me bond NH O a bond T3i OH

3480 CMe O Q1i a bond Me bond NH O a bond T3j OH

3481 CMe O Q1i a bond H a bond NH S NH T3a OH

3482 CMe O Q1i a bond H a bond NH S NH T3b OH

3483 CMe O Q1i a bond H a bond NH S NH T3c OH

3484 CMe O Q1i a bond H a bond NH S NH T3d OH

3485 CMe O Q1i a bond H a bond NH S NH T3e OH

3486 CMe O Q1i a bond H a bond NH S NH T3f OH

3487 CMe O Q1i a bond H a bond NH S NH T3g OH

3488 CMe O Q1i a bond H a bond NH S NH T3h OH

3489 CMe O Q1i a bond H a bond NH S NH T3i OH

3490 CMe O Q1i a bond H a bond NH S NH T3j OH

3491 CMe O Q1i a bond H a bond NH S a bond T3a OH

3492 CMe O Q1i a bond H a bond NH S a bond T3b OH

3493 CMe O Q1i a bond H a bond NH S a bond T3c OH

3494 CMe O Q1i a bond H a bond NH S a bond T3d OH

3495 CMe O Q1i a bond H a bond NH S a bond T3e OH

3496 CMe O Q1i a bond H a bond NH S a bond T3f OH

3497 CMe O Q1i a bond H a bond NH S a bond T3g OH

3498 CMe O Q1i a bond H a bond NH S a bond T3h OH

3499 CMe O Q1i a bond H a bond NH S a bond T3i OH

3500 CMe O Q1i a bond H a bond NH S a bond T3j OH

3501 CMe O Q1i a bond H a bond NH O NH T3a OH

3502 CMe O Q1i a bond H a bond NH O NH T3b OH

3503 CMe O Q1i a bond H a bond NH O NH T3c OH

3504 CMe O Q1i a bond H a bond NH O NH T3d OH

3505 CMe O Q1i a bond H a bond NH O NH T3e OH

3506 CMe O Q1i a bond H a bond NH O NH T3f OH

3507 CMe O Q1i a bond H a bond NH O NH T3g OH

3508 CMe O Q1i a bond H a bond NH O NH T3h OH

3509 CMe O Q1i a bond H a bond NH O NH T3i OH

3510 CMe O Q1i a bond H a bond NH O NH T3j OH

3511 CMe O Q1i a bond H a bond NH O a bond T3a OH

3512 CMe O Q1i a bond H a bond NH O a bond T3b OH

3513 CMe O Q1i a bond H a bond NH O a bond T3c OH

3514 CMe O Q1i a bond H a bond NH O a bond T3d OH

3515 CMe O Q1i a bond H a bond NH O a bond T3e OH

3516 CMe O Q1i a bond H a bond NH O a bond T3f OH

3517 CMe O Q1i a bond H a bond NH O a bond T3g OH

3518 CMe O Q1i a bond H a bond NH O a bond T3h OH

3519 CMe O Q1i a bond H a bond NH O a bond T3i OH

3520 CMe O Q1i a bond H a bond NH O a bond T3j OH

3521 CMe O Q1j a bond Me bond NH S NH T3a OH

3522 CMe O Q1j a bond Me bond NH S NH T3b OH

3523 CMe O Q1j a bond Me bond NH S NH T3c OH

3524 CMe O Q1j a bond Me bond NH S NH T3d OH

3525 CMe O Q1j a bond Me bond NH S NH T3e OH

3526 CMe O Q1j a bond Me bond NH S NH T3f OH

3527 CMe O Q1j a bond Me bond NH S NH T3g OH

3528 CMe O Q1j a bond Me bond NH S NH T3h OH

3529 CMe O Q1j a bond Me bond NH S NH T3i OH

3530 CMe O Q1j a bond Me bond NH S NH T3j OH

3531 CMe O Q1j a bond Me bond NH S a bond T3a OH

3532 CMe O Q1j a bond Me bond NH S a bond T3b OH

3533 CMe O Q1j a bond Me bond NH S a bond T3c OH

3534 CMe O Q1j a bond Me bond NH S a bond T3d OH

3535 CMe O Q1j a bond Me bond NH S a bond T3e OH

3536 CMe O Q1j a bond Me bond NH S a bond T3f OH

3537 CMe O Q1j a bond Me bond NH S a bond T3g OH

3538 CMe O Q1j a bond Me bond NH S a bond T3h OH

3539 CMe O Q1j a bond Me bond NH S a bond T3i OH

3540 CMe O Q1j a bond Me bond NH S a bond T3j OH

3541 CMe O Q1j a bond Me bond NH O NH T3a OH

3542 CMe O Q1j a bond Me bond NH O H T3b OH

3543 CMe O Q1j a bond Me bond NH O NH T3c OH

3544 CMe O Q1j a bond Me bond NH O NH T3d OH

3545 CMe O Q1j a bond Me bond NH O NH T3e OH

3546 CMe O Q1j a bond Me bond NH O NH T3f OH

3547 CMe O Q1j a bond Me bond NH O NH T3g OH

3548 CMe O Q1j a bond Me bond NH O NH T3h OH

3549 CMe O Q1j a bond Me bond NH O NH T3i OH

3550 CMe O Q1j a bond Me bond NH O NH T3j OH

3551 CMe O Q1j a bond Me bond NH O a bond T3a OH

3552 CMe O Q1j a bond Me bond NH O a bond T3b OH

3553 CMe O Q1j a bond Me bond NH O a bond T3c OH

3554 CMe O Q1j a bond Me bond NH O a bond T3d OH

3555 CMe O Q1j a bond Me bond NH O a bond T3e OH

3556 CMe O Q1j a bond Me bond NH O a bond T3f OH

3557 CMe O Q1j a bond Me bond NH O a bond T3g OH

3558 CMe O Q1j a bond Me bond NH O a bond T3h OH

3559 CMe O Q1j a bond Me bond NH O a bond T3i OH

3560 CMe O Q1j a bond Me bond NH O a bond T3j OH

3561 CMe O Q1j a bond H a bond NH S NH T3a OH

3562 CMe O Q1j a bond H a bond NH S NH T3b OH

3563 CMe O Q1j a bond H a bond NH S NH T3c OH

3564 CMe O Q1j a bond H a bond NH S NH T3d OH

3565 CMe O Q1j a bond H a bond NH S NH T3e OH

3566 CMe O Q1j a bond H a bond NH S NH T3f OH

3567 CMe O Q1j a bond H a bond NH S NH T3g OH

3568 CMe O Q1j a bond H a bond NH S NH T3h OH

3569 CMe O Q1j a bond H a bond NH S NH T3i OH

3570 CMe O Q1j a bond H a bond NH S NH T3j OH

3571 CMe O Q1j a bond H a bond NH S a bond T3a OH

3572 CMe O Q1j a bond H a bond NH S a bond T3b OH

3573 CMe O Q1j a bond H a bond NH S a bond T3c OH

3574 CMe O Q1j a bond H a bond NH S a bond T3d OH

3575 CMe O Q1j a bond H a bond NH S a bond T3e OH

3576 CMe O Q1j a bond H a bond NH S a bond T3f OH

3577 CMe O Q1j a bond H a bond NH S a bond T3g OH

3578 CMe O Q1j a bond H a bond NH S a bond T3h OH

379 CMe O Q1j a bond H a bond NH S a bond T3i OH

3580 CMe O Q1j a bond H a bond NH S a bond T3j OH

3581 CMe O Q1j a bond H a bond NH O NH T3a OH

3582 CMe O Q1j a bond H a bond NH O NH T3b OH

3583 CMe O Q1j a bond H a bond NH O NH T3c OH

3584 CMe O Q1j a bond H a bond NH O NH T3d OH

3585 CMe O Q1j a bond H a bond NH O NH T3e OH

3586 CMe O Q1j a bond H a bond NH O NH T3f OH

3587 CMe O Q1j a bond H a bond NH O NH T3g OH

3588 CMe O Q1j a bond H a bond NH O NH T3h OH

3589 CMe O Q1j a bond H a bond NH O NH T3i OH

3590 CMe O Q1j a bond H a bond NH O NH T3j OH

3591 CMe O Q1j a bond H a bond NH O a bond T3a OH

3592 CMe O Q1j a bond H a bond NH O a bond T3b OH

3593 CMe O Q1j a bond H a bond NH O a bond T3c OH

3594 CMe O Q1j a bond H a bond NH O a bond T3d OH

3595 CMe O Q1j a bond H a bond NH O a bond T3e OH

3596 CMe O Q1j a bond H a bond NH O a bond T3f OH

3597 CMe O Q1j a bond H a bond NH O a bond T3g OH

3598 CMe O Q1j a bond H a bond NH O a bond T3h OH

3599 CMe O Q1j a bond H a bond NH O a bond T3i OH

3600 CMe O Q1j a bond H a bond NH O a bond T3j OH

3601 N NMe Q1i a bond Me bond NH S NH Q3e OH

3602 N NMe Q1i a bond Me bond NH S a bond Q3e OH

3603 N NMe Q1i a bond Me bond NH O NH Q3e OH

3604 N NMe Q1i a bond Me bond NH O a bond Q3e OH

3605 N NMe Q1i a bond H a bond NH S NH Q3e OH

3606 N NMe Q1i a bond H a bond NH S a bond Q3e OH

3607 N NMe Q1i a bond H a bond NH O NH Q3e OH

3608 N NMe Q1i a bond H a bond NH O a bond Q3e OH

3609 N NMe Q1j a bond Me bond NH S NH Q3e OH

3610 N NMe Q1j a bond Me bond NH S a bond Q3e OH

3611 N NMe Q1j a bond Me bond NH O NH Q3e OH

3612 N NMe Q1j a bond Me bond NH O a bond Q3e OH

3613 N NMe Q1j a bond H a bond NH S NH Q3e OH

3614 N NMe Q1j a bond H a bond NH S a bond Q3e OH

3615 N NMe Q1j a bond H a bond NH O NH Q3e OH

3616 N NMe 1j bond H a bond NH O a bond Q3e OH

3617 N S Q1i a bond Me bond NH S NH Q3e OH

3618 N S Q1i a bond Me bond NH S a bond Q3e OH

3619 N S Q1i a bond Me bond NH O NH Q3e OH

3620 N S Q1i a bond Me bond NH O a bond Q3e OH

3621 N S Q1i a bond H a bond NH S NH Q3e OH

3622 N S Q1i a bond H a bond NH S a bond Q3e OH

3623 N S Q1i a bond H a bond NH O NH Q3e OH

3624 N S Q1i a bond H a bond NH O a bond Q3e OH

3625 N S Q1j a bond Me bond NH S NH Q3e OH

3626 N S Q1j a bond Me bond NH S a bond Q3e OH

3627 N S Q1j a bond Me bond NH O NH Q3e OH

3628 N S Q1j a bond Me bond NH O a bond Q3e OH

3629 N S Q1j a bond H a bond NH S NH Q3e OH

3630 N S Q1j a bond H a bond NH S a bond Q3e OH

3631 N S Q1j a bond H a bond NH O NH Q3e OH

3632 N S Q1j a bond H a bond NH O a bond Q3e OH

3633 N O Q1i a bond Me bond NH S NH Q3e OH

3634 N O Q1i a bond Me bond NH S a bond Q3e OH

3635 N O Q1i a bond Me bond NH O NH Q3e OH

3636 N O Q1i a bond Me bond NH O a bond Q3e OH

3637 N O Q1i a bond H a bond NH S NH Q3e OH

3638 N O Q1i a bond H a bond NH S a bond Q3e OH

3639 N O Q1i a bond H a bond NH O NH Q3e OH

3640 N O Q1i a bond H a bond NH O a bond Q3e OH

3641 N O Q1j a bond Me bond NH S NH Q3e OH

3642 N O Q1j a bond Me bond NH S a bond Q3e OH

3643 N O Q1j a bond Me bond NH O NH Q3e OH

3644 N O Q1j a bond Me bond NH O a bond Q3e OH

3645 N O Q1j a bond H a bond NH S NH Q3e OH

3646 N O Q1j a bond H a bond NH S a bond Q3e OH

3647 N O Q1j a bond H a bond NH O NH Q3e OH

3648 N O Q1j a bond H a bond NH O a bond Q3e OH

of 3,649 CH NMe Q1i a bond Me bond NH S NH Q3e OH

3650 CH NMe Q1i a bond Me bond NH S a bond Q3e OH

3651 CH NMe Q1i a bond Me bond NH O NH Q3e OH

3652 CH NMe Q1i a bond Me bond NH O a bond Q3e OH

3653 CH NMe Q1i a bond H a bond NH S NH Q3e OH

p> 3654 CH NMe Q1i a bond H a bond NH S a bond Q3e OH

3655 CH NMe Q1i a bond H a bond NH O NH Q3e OH

3656 CH NMe Q1i a bond H a bond NH O a bond Q3e OH

3657 CH NMe Q1j a bond Me bond NH S NH Q3e OH

3658 CH NMe Q1j a bond Me bond NH S a bond Q3e OH

3659 CH NMe Q1j a bond Me bond NH O NH Q3e OH

3660 CH NMe Q1j a bond Me bond NH O a bond Q3e OH

3661 CH NMe Q1j a bond H a bond NH S NH Q3e OH

3662 CH NMe Q1j a bond H a bond NH S a bond Q3e OH

of 3,663 CH NMe Q1j a bond H a bond NH O NH Q3e OH

3664 CH NMe Q1j a bond H a bond NH O a bond Q3e OH

3665 CH S Q1i a bond Me bond NH S NH Q3e OH

3666 CH S Q1i a bond Me bond NH S a bond Q3e OH

3667 CH S Q1i a bond Me bond NH O NH Q3e OH

3668 CH S Q1i a bond Me bond NH O a bond Q3e OH

3669 CH S Q1i a bond H a bond NH S NH Q3e OH

3670 CH S Q1i a bond H a bond NH S a bond Q3e OH

3671 CH S Q1i a bond H a bond NH O NH Q3e OH

3672 CH S Q1i a bond H a bond NH O a bond Q3e OH

3673 CH S Q1j a bond Me bond NH S NH Q3e OH

3674 CH S Q1j a bond Me bond NH S a bond Q3e OH

3675 CH S Q1j a bond Me bond NH O NH Q3e OH

3676 CH S Q1j a bond Me bond NH O a bond Q3e OH

3677 CH S Q1j a bond H a bond NH S NH Q3e OH

3678 CH S Q1j a bond H a bond NH S a bond Q3e OH

3679 CH S Q1j a bond H a bond NH O NH Q3e OH

3680 CH S Q1j a bond H a bond NH O a bond Q3e OH

3681 CH O Q1i a bond Me bond NH S NH Q3e OH

3682 CH O Q1i a bond Me bond NH S a bond Q3e OH

3683 CH O Q1i a bond Me bond NH O NH Q3e OH

3684 CH O Q1i a bond Me bond NH O a bond Q3e OH

3685 CH O Q1i a bond H a bond NH S NH Q3e OH

3686 CH O Q1i a bond H a bond NH S a bond Q3e OH

3687 CH O Q1i a bond H a bond NH O NH Q3e OH

3688 CH O Q1i a bond H a bond NH O a bond Q3e OH

3689 CH O Q1j a bond Me bond NH S NH Q3e OH

3690 CH O Q1j of light is ü Me bond NH S a bond Q3e OH

3691 CH O Q1j a bond Me bond NH O NH Q3e OH

3692 CH O Q1j a bond Me bond NH O a bond Q3e OH

3693 CH O Q1j a bond H a bond NH S NH Q3e OH

3694 CH O Q1j a bond H a bond NH S a bond Q3e OH

3695 CH O Q1j a bond H a bond NH O NH Q3e OH

3696 CH O Q1j a bond H a bond NH O a bond Q3e OH

3697 CMe NMe Q1i a bond Me bond NH S NH Q3e OH

3698 CMe NMe Q1i a bond Me bond NH S a bond Q3e OH

3699 CMe NMe Q1i a bond Me bond NH O NH Q3e OH

3700 CMe NMe Q1i a bond Me bond NH O a bond Q3e OH

3701 CMe NMe Q1i a bond H a bond NH S NH Q3e OH

3702 CMe NMe Q1i a bond H a bond NH S a bond Q3e OH

3703 CMe NMe Q1i a bond H a bond NH O NH Q3e OH

3704 CMe NMe Q1i a bond H a bond NH O a bond Q3e OH

3705 CMe NMe Q1j a bond Me bond NH S NH Q3e OH

3706 CMe NMe Q1j a bond Me bond NH S a bond Q3e OH

3707 CMe NMe Q1j a bond Me bond NH O NH Q3e OH

3708 CMe NMe Q1j a bond Me bond NH O a bond Q3e OH

3709 CMe NMe Q1j a bond H a bond NH S NH Q3e OH

3710 CMe NMe Q1j a bond H a bond NH S a bond Q3e OH

3711 CMe NMe Q1j a bond H a bond NH O NH Q3e OH

3712 CMe NMe Q1j a bond H a bond NH O a bond Q3e OH

3713 CMe S Q1i a bond Me bond NH S NH Q3e OH

3714 CMe S Q1i a bond Me bond NH S a bond Q3e OH

3715 CMe S Q1i a bond Me bond NH O NH Q3e OH

3716 CMe S Q1i a bond Me bond NH O a bond Q3e OH

3717 CMe S Q1i a bond H a bond NH S NH Q3e OH

3718 CMe S Q1i a bond H a bond NH S a bond Q3e OH

3719 CMe S Q1i a bond H a bond NH O NH Q3e OH

3720 CMe S Q1i a bond H a bond NH O a bond Q3e OH

3721 CMe S Q1j a bond Me bond NH S NH Q3e OH

3722 CMe S Q1j a bond Me bond NH S a bond Q3e OH

3723 CMe S Q1j a bond Me bond NH O NH Q3e OH

3724 CMe S Q1j a bond Me bond NH O a bond Q3e OH

3725 CMe S Q1j a bond H a bond NH S NH Q3e OH

3726 CMe S Q1j a bond H a bond NH S the ligature Q3e OH

3727 CMe S Q1j a bond H a bond NH O NH Q3e OH

3728 CMe S Q1j a bond H a bond NH O a bond Q3e OH

3729 CMe O Q1i a bond Me bond NH S NH Q3e OH

3730 CMe O Q1i a bond Me bond NH S a bond Q3e OH

3731 CMe O Q1i a bond Me bond NH O NH Q3e OH

3732 CMe O Q1i a bond Me bond NH O a bond Q3e OH

3733 CMe O Q1i a bond H a bond NH S NH Q3e OH

3734 CMe O Q1i a bond H a bond NH S a bond Q3e OH

3735 CMe O Q1i a bond H a bond NH O NH Q3e OH

3736 CMe O Q1i a bond H a bond NH O a bond Q3e OH

3737 CMe O Q1j a bond Me bond NH S NH Q3e OH

3738 CMe O Q1j a bond Me bond NH S a bond Q3e OH

3739 CMe O Q1j a bond Me bond NH O NH Q3e OH

3740 CMe O Q1j a bond Me bond NH O a bond Q3e OH

3741 CMe O Q1j a bond H a bond NH S NH Q3e OH

3742 CMe O Q1j a bond H a bond NH S a bond Q3e OH

3743 CMe O Q1j a bond H a bond NH O NH Q3e OH

3744 CMe O Q1j a bond H a bond NH O a bond Q3e OH

________________________________________________

64. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

65. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceuticas is acceptable salts of these compounds or their solvate (provided what if p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

66. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

67. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

68. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and Tj in table 1 mean the following placeholders).

69. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

70. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case of item 70) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

71. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

72. Compounds in which the A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the following combinations of table 2; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate. The symbols in table 2 indicate the following placeholders.

Table 2

--------------------------------------------

No A B R1L1R2L2L3Y L4R3X

--------------------------------------------

1 N NMe Q1a NH Me bond NH S NH Q3a OH

2 N NMe Q1a NH Me bond NH S a bond Q3a OH

3 N NMe Q1a NH Me bond NH O NH Q3a OH

4 N NMe Q1a NH Me bond NH O a bond Q3a OH

5 N NMe Q1a NH H a bond NH S NH Q3a OH

6 N NMe Q1a NH H a bond NH S a bond Q3a OH

7 N NMe Q1a NH H a bond NH O NH Q3a OH

8 N NMe Q1a NH H a bond NH O a bond Q3a OH

9 N NMe Q1b NH Me bond NH S NH Q3a OH

10 N NMe Q1b NH Me bond NH S a bond Q3a OH

11 N NMe Q1b NH Me bond NH O NH Q3a OH

12 N NMe Q1b NH Me bond NH O a bond Q3a OH

13 N NMe Q1b NH H a bond NH S NH Q3a OH

14 N NMe Q1b NH H a bond NH S a bond Q3a OH

15 N NMe Q1b NH H a bond NH O NH Q3a OH

16 N NMe Q1b NH H a bond NH O a bond Q3a OH

17 N S Q1a NH Me bond NH S NH Q3a OH

18 N S Q1a NH Me bond NH S a bond Q3a OH

19 N S Q1a NH Me bond NH O NH Q3a OH

20 N S Q1a NH Me bond NH O a bond Q3a OH

21 N S Q1a NH H a bond NH S NH Q3a OH

22 N S Q1a NH H a bond NH S a bond Q3a OH

23 N S Q1a NH H a bond NH O NH Q3a OH

24 N S Q1a NH H a bond NH O a bond Q3a OH

25 N S Q1b NH Me bond NH S NH Q3a OH

26 N S Q1b NH Me bond NH S a bond Q3a OH

27 N S Q1b NH Me bond NH O NH Q3a OH

28 N S Q1b NH Me bond NH O a bond Q3a OH

29 N S Q1b NH H a bond NH S NH Q3a OH

30 N S Q1b NH H a bond NH S a bond Q3a OH

31 N S Q1b NH H a bond NH O NH Q3a OH

32 N S Q1b NH H a bond NH O a bond Q3a OH

33 N O Q1a NH Me bond NH S NH Q3a OH

34 N O Q1a NH Me bond NH S a bond Q3a OH

35 N O Q1a NH Me bond NH O NH Q3a OH

36 N O Q1a NH Me bond NH O a bond Q3a OH

37 N O Q1a NH H a bond NH S NH Q3a OH

38 N O Q1a NH H a bond NH S a bond Q3a OH

39 N O Q1a NH H a bond NH O NH Q3a OH

40 N O Q1a NH H a bond NH O a bond Q3a OH

41 N O Q1b NH Me bond NH S NH Q3a OH

42 N O Q1b NH Me bond NH S a bond Q3a OH

43 N O Q1b NH Me bond NH O NH Q3a OH

44 N O Q1b NH Me bond NH O a bond Q3a OH

45 N O Q1b NH H a bond NH S NH Q3a OH

46 N O Q1b NH H a bond NH S a bond Q3a OH

47 N O Q1b NH H a bond NH O NH Q3a OH

48 N O Q1b NH H a bond NH O a bond Q3a OH

49 CH NMe Q1a NH Me bond NH S NH Q3a OH

50 CH NMe Q1a NH Me bond NH S a bond Q3a OH

51 CH NMe Q1a NH Me bond NH O NH Q3a OH

52 CH NMe Q1a NH Me bond NH O a bond Q3a OH

53 CH NMe Q1a NH H a bond NH S NH Q3a OH

54 CH NMe Q1a NH H a bond NH S a bond Q3a OH

55 CH NMe Q1a NH H a bond NH O NH Q3a OH

56 CH NMe Q1a NH H a bond NH O a bond Q3a OH

57 CH NMe Q1b NH Me bond NH S NH Q3a OH

58 CH NMe Q1b NH Me bond NH S a bond Q3a OH

59 CH NMe Q1b NH Me bond NH O NH Q3a OH

60 CH NMe Q1b NH Me bond NH O a bond Q3a OH

61 CH NMe Q1b NH H a bond NH S NH Q3a OH

62 CH NMe Q1b NH H a bond NH S a bond Q3a OH

63 CH NMe Q1b NH H a bond NH O NH Q3a OH

64 CH NMe Q1b NH H a bond NH O a bond Q3a OH

65 CH S Q1a NH Me bond NH S NH Q3a OH

66 CH S Q1a NH Me bond NH S a bond Q3a OH

67 CH S Q1a NH Me bond NH O NH Q3a OH

68 CH S Q1a NH Me bond NH O a bond Q3a OH

70 CH S Q1a NH H a bond NH S a bond Q3a OH

71 CH S Q1a NH H a bond NH O NH Q3a OH

72 CH S Q1a NH H a bond NH O a bond Q3a OH

73 CH S Q1b NH Me bond NH S NH Q3a OH

74 CH S Q1b NH Me bond NH S a bond Q3a OH

75 CH S Q1b NH Me bond NH O NH Q3a OH

76 CH S Q1b NH Me bond NH O a bond Q3a OH

77 CH S Q1b NH H a bond NH S NH Q3a OH

78 CH S Q1b NH H a bond NH S a bond Q3a OH

79 CH S Q1b NH H a bond NH O NH Q3a OH

80 CH S Q1b NH H a bond NH O a bond Q3a OH

81 CH O Q1a NH Me bond NH S NH Q3a OH

82 CH O Q1a NH Me bond NH S a bond Q3a OH

83 CH O Q1a NH Me bond NH O NH Q3a OH

84 CH O Q1a NH Me bond NH O a bond Q3a OH

85 CH O Q1a NH H a bond NH S NH Q3a OH

86 CH O Q1a NH H a bond NH S a bond Q3a OH

87 CH O Q1a NH H a bond NH O NH Q3a OH

88 CH O Q1a NH H a bond NH O a bond Q3a OH

89 CH O Q1b NH Me bond NH S NH Q3a OH

90 CH O Q1b NH Me bond NH S a bond Q3a OH

91 CH O Q1b NH Me bond NH O NH Q3a OH

92 CH O Q1b NH Me bond NH O a bond Q3a OH

93 CH O Q1b NH H a bond NH S NH Q3a OH

94 CH O Q1b NH H a bond NH S a bond Q3a OH

95 CH O Q1b NH H a bond NH O NH Q3a OH

96 CH O Q1b NH H a bond NH O a bond Q3a OH

97 CMe NMe Q1a NH Me bond NH S NH Q3a OH

98 CMe NMe Q1a NH Me bond NH S a bond Q3a OH

99 CMe NMe Q1a NH Me bond NH O NH Q3a OH

100 CMe NMe Q1a NH Me bond NH O a bond Q3a OH

101 CMe NMe Q1a NH H a bond NH S NH Q3a OH

102 CMe NMe Q1a NH H a bond NH S a bond Q3a OH

103 CMe NMe Q1a NH H a bond NH O NH Q3a OH

104 CMe NMe Q1a NH H a bond NH O a bond Q3a OH

105 CMe NMe Q1b NH Me bond NH S NH Q3a OH

106 CMe NMe Q1b NH Me bond NH S a bond Q3a OH

107 CMe NMe Q1b NH Me bond NH O NH Q3a OH

108 CMe NMe Q1b NH Me bond NH O a bond Q3a OH

109 CMe NMe Q1b NH H a bond NH S NH Q3a OH

110 CMe NMe Q1b NH H a bond NH S a bond Q3a OH

111 CMe NMe Q1b NH H a bond NH O NH Q3a OH

112 CMe Me Q1b NH H a bond NH O a bond Q3a OH

113 CMe S Q1a NH Me bond NH S NH Q3a OH

114 CMe S Q1a NH Me bond NH S a bond Q3a OH

115 CMe S Q1a NH Me bond NH O NH Q3a OH

116 CMe S Q1a NH Me bond NH O a bond Q3a OH

117 CMe S Q1a NH H a bond NH S NH Q3a OH

118 CMe S Q1a NH H a bond NH S a bond Q3a OH

119 CMe S Q1a NH H a bond NH O NH Q3a OH

120 CMe S Q1a NH H a bond NH O a bond Q3a OH

121 CMe S Q1b NH Me bond NH S NH Q3a OH

122 CMe S Q1b NH Me bond NH S a bond Q3a OH

123 CMe S Q1b NH Me bond NH O NH Q3a OH

124 CMe S Q1b NH Me bond NH O a bond Q3a OH

125 CMe S Q1b NH H a bond NH S NH Q3a OH

126 CMe S Q1b NH H a bond NH S a bond Q3a OH

127 CMe S Q1b NH H a bond NH O NH Q3a OH

128 CMe S Q1b NH H a bond NH O a bond Q3a OH

129 CMe O Q1a NH Me bond NH S NH Q3a OH

130 CMe O Q1a NH Me bond NH S a bond Q3a OH

131 CMe O Q1a NH Me bond NH O NH Q3a OH

132 CMe O Q1a NH Me bond NH O a bond Q3a OH

133 CMe O Q1a NH H a bond NH S NH Q3a OH

134 CMe O Q1a NH H a bond NH S a bond Q3a OH

135 CMe O Q1a NH H a bond NH O NH Q3a OH

136 CMe O Q1a NH H a bond NH O a bond Q3a OH

137 CMe O Q1b NH Me bond NH S NH Q3a OH

138 CMe O Q1b NH Me bond NH S a bond Q3a OH

139 CMe O Q1b NH Me bond NH O NH Q3a OH

140 CMe O Q1b NH Me bond NH O a bond Q3a OH

141 CMe O Q1b NH H a bond NH S NH Q3a OH

142 CMe O Q1b NH H a bond NH S a bond Q3a OH

143 CMe O Q1b NH H a bond NH O NH Q3a OH

144 CMe O Q1b NH H a bond NH O a bond Q3a OH

145 N NMe Q1a O Me bond NH S NH Q3a OH

146 N NMe Q1a O Me bond NH S a bond Q3a OH

147 N NMe Q1a O Me bond NH O NH Q3a OH

148 N NMe Q1a O Me bond NH O a bond Q3a OH

149 N NMe Q1a O H a bond NH S NH Q3a OH

150 N NMe Q1a O H a bond NH S a bond Q3a OH

151 N NMe Q1a O H a bond NH O NH Q3a OH

152 N NMe Q1a O H a bond NH O a bond Q3a OH

153 N NMe Q1b O Me bond NH S NH Q3a OH

154 N NMe Q1b O Me bond NH S a bond Q3a H

155 N NMe Q1b O Me bond NH O NH Q3a OH

156 N NMe Q1b O Me bond NH O a bond Q3a OH

157 N NMe Q1b O H a bond NH S NH Q3a OH

158 N NMe Q1b O H a bond NH S a bond Q3a OH

159 N NMe Q1b O H a bond NH O NH Q3a OH

160 N NMe Q1b O H a bond NH O a bond Q3a OH

161 N S Q1a O Me bond NH S NH Q3a OH

162 N S Q1a O Me bond NH S a bond Q3a OH

163 N S Q1a O Me bond NH O NH Q3a OH

164 N S Q1a O Me bond NH O a bond Q3a OH

165 N S Q1a O H a bond NH S NH Q3a OH

166 N S Q1a O H a bond NH S a bond Q3a OH

167 N S Q1a O H a bond NH O NH Q3a OH

168 N S Q1a O H a bond NH O a bond Q3a OH

169 N S Q1b O Me bond NH S NH Q3a OH

170 N S Q1b O Me bond NH S a bond Q3a OH

171 N S Q1b O Me bond NH O NH Q3a OH

172 N S Q1b O Me bond NH O a bond Q3a OH

173 N S Q1b O H a bond NH S NH Q3a OH

174 N S Q1b O H a bond NH S a bond Q3a OH

175 N S Q1b O H a bond NH O NH Q3a OH

176 N S Q1b O H a bond NH O a bond Q3a OH

177 N O Q1a O Me bond NH S NH Q3a OH

178 N O Q1a O Me bond NH S a bond Q3a OH

179 N O Q1a O Me bond NH O NH Q3a OH

180 N O Q1a O Me bond NH O a bond Q3a OH

181 N O Q1a O H a bond NH S NH Q3a OH

182 N O Q1a O H a bond NH S a bond Q3a OH

183 N O Q1a O H a bond NH O NH Q3a OH

184 N O Q1a O H a bond NH O a bond Q3a OH

185 N O Q1b O Me bond NH S NH Q3a OH

186 N O Q1b O Me bond NH S a bond Q3a OH

187 O N O Q1b Me bond NH O NH Q3a OH

188 N O Q1b O Me bond NH O a bond Q3a OH

189 N O Q1b O H a bond NH S NH Q3a OH

190 N O Q1b O H a bond NH S a bond Q3a OH

191 N O Q1b O H a bond NH O NH Q3a OH

192 N O Q1b O H a bond NH O a bond Q3a OH

193 CH NMe Q1a O Me bond NH S NH Q3a OH

194 CH NMe Q1a O Me bond NH S a bond Q3a OH

195 CH NMe Q1a O Me bond NH O NH Q3a OH

196 CH NMe Q1a O Me bond NH O a bond Q3a OH

197 CH NMe Q1a O H a bond NH S NH Q3a OH

198 CH NMe Q1a O H tie the NH S a bond Q3a OH

199 CH NMe Q1a O H a bond NH O NH Q3a OH

200 CH NMe Q1a O H a bond NH O a bond Q3a OH

201 CH NMe Q1b O Me bond NH S NH Q3a OH

202 CH NMe Q1b O Me bond NH S a bond Q3a OH

203 CH NMe Q1b O Me bond NH O NH Q3a OH

204 CH NMe Q1b O Me bond NH O a bond Q3a OH

205 CH NMe Q1b O H a bond NH S NH Q3a OH

206 CH NMe Q1b O H a bond NH S a bond Q3a OH

207 CH NMe Q1b O H a bond NH O NH Q3a OH

208 CH NMe Q1b O H a bond NH O a bond Q3a OH

209 CH S O Q1a Me bond NH S NH Q3a OH

210 CH S O Q1a Me bond NH S a bond Q3a OH

211 CH S O Q1a Me bond NH O NH Q3a OH

212 CH S O Q1a Me bond NH O a bond Q3a OH

213 CH S Q1a O H a bond NH S NH Q3a OH

214 CH S Q1a O H a bond NH S a bond Q3a OH

215 CH S Q1a O H a bond NH O NH Q3a OH

216 CH S Q1a O H a bond NH O a bond Q3a OH

217 CH S O Q1b Me bond NH S NH Q3a OH

218 CH S O Q1b Me bond NH S a bond Q3a OH

219 CH S O Q1b Me bond NH O NH Q3a OH

220 CH S O Q1b Me bond NH O a bond Q3a OH

221 CH S Q1b O H a bond NH S NH Q3a OH

222 CH S Q1b O H a bond NH S a bond Q3a OH

223 CH S Q1b O H a bond NH O NH Q3a OH

224 CH S Q1b O H a bond NH O a bond Q3a OH

225 CH O O Q1a Me bond NH S NH Q3a OH

226 CH O O Q1a Me bond NH S a bond Q3a OH

227 CH O O Q1a Me bond NH O NH Q3a OH

228 CH O O Q1a Me bond NH O a bond Q3a OH

229 CH O Q1a O H a bond NH S NH Q3a OH

230 CH O Q1a O H a bond NH S a bond Q3a OH

231 CH O Q1a O H a bond NH O NH Q3a OH

232 CH O Q1a O H a bond NH O a bond Q3a OH

233 CH O O Q1b Me bond NH S NH Q3a OH

234 CH O O Q1b Me bond NH S a bond Q3a OH

235 CH O O Q1b Me bond NH O NH Q3a OH

236 CH O O Q1b Me bond NH O a bond Q3a OH

237 CH O Q1b O H a bond NH S NH Q3a OH

238 CH O Q1b O H a bond NH S a bond Q3a OH

239 CH O Q1b O H a bond NH O NH Q3a OH

240 CH O Q1b O H a bond NH O a bond Q3a OH

241 CMe NMe Q1a O Me bond NH S NH Q3a O

242 CMe NMe Q1a O Me bond NH S a bond Q3a OH

243 CMe NMe Q1a O Me bond NH O NH Q3a OH

244 CMe NMe Q1a O Me bond NH O a bond Q3a OH

245 CMe NMe Q1a O H a bond NH S NH Q3a OH

246 CMe NMe Q1a O H a bond NH S a bond Q3a OH

247 CMe NMe Q1a O H a bond NH O NH Q3a OH

248 CMe NMe Q1a O H a bond NH O a bond Q3a OH

249 CMe NMe Q1b O Me bond NH S NH Q3a OH

250 CMe NMe Q1b O Me bond NH S a bond Q3a OH

251 CMe NMe Q1b O Me bond NH O NH Q3a OH

252 CMe NMe Q1b O Me bond NH O a bond Q3a OH

253 CMe NMe Q1b O H a bond NH S NH Q3a OH

254 CMe NMe Q1b O H a bond NH S a bond Q3a OH

255 CMe NMe Q1b O H a bond NH O NH Q3a OH

256 CMe NMe Q1b O H a bond NH O a bond Q3a OH

257 CMe S O Q1a Me bond NH S NH Q3a OH

258 CMe S O Q1a Me bond NH S a bond Q3a OH

259 CMe S O Q1a Me bond NH O NH Q3a OH

260 CMe S O Q1a Me bond NH O a bond Q3a OH

261 CMe S Q1a O H a bond NH S NH Q3a OH

262 CMe S Q1a O H a bond NH S a bond Q3a OH

263 CMe S Q1a O H a bond NH O NH Q3a OH

264 CMe S Q1a O H a bond NH O a bond Q3a OH

265 CMe S O Q1b Me bond NH S NH Q3a OH

266 CMe S O Q1b Me bond NH S a bond Q3a OH

267 CMe S O Q1b Me bond NH O NH Q3a OH

268 CMe S O Q1b Me bond NH O a bond Q3a OH

269 CMe S Q1b O H a bond NH S NH Q3a OH

270 CMe S Q1b O H a bond NH S a bond Q3a OH

271 CMe S Q1b O H a bond NH O NH Q3a OH

272 CMe S Q1b O H a bond NH O a bond Q3a OH

273 CMe O O Q1a Me bond NH S NH Q3a OH

274 CMe O O Q1a Me bond NH S a bond Q3a OH

275 CMe O O Q1a Me bond NH O NH Q3a OH

276 CMe O O Q1a Me bond NH O a bond Q3a OH

277 CMe O Q1a O H a bond NH S NH Q3a OH

278 CMe O Q1a O H a bond NH S a bond Q3a OH

279 CMe O Q1a O H a bond NH O NH Q3a OH

280 CMe O Q1a O H a bond NH O a bond Q3a OH

281 CMe O O Q1b Me bond NH S NH Q3a OH

282 CMe O O Q1b Me bond NH S a bond Q3a OH

283 CMe O O Q1b Me bond NH O NH Q3a OH/p>

284 CMe O O Q1b Me bond NH O a bond Q3a OH

285 CMe O Q1b O H a bond NH S NH Q3a OH

286 CMe O Q1b O H a bond NH S a bond Q3a OH

287 CMe O Q1b O H a bond NH O NH Q3a OH

288 CMe O Q1b O H a bond NH O a bond Q3a OH

289 N NMe Q1a CH2 Me bond NH S NH Q3a OH

290 N NMe Q1a CH2 Me bond NH S a bond Q3a OH

291 N NMe Q1a CH2 Me bond NH O NH Q3a OH

292 N NMe Q1a CH2 Me bond NH O a bond Q3a OH

293 N NMe Q1a CH2 H a bond NH S NH Q3a OH

294 N NMe Q1a CH2 H a bond NH S a bond Q3a OH

295 N NMe Q1a CH2 H a bond NH O NH Q3a OH

296 N NMe Q1a CH2 H a bond NH O a bond Q3a OH

297 N NMe Q1b CH2 Me bond NH S NH Q3a OH

298 N NMe Q1b CH2 Me bond NH S a bond Q3a OH

299 N NMe Q1b CH2 Me bond NH O NH Q3a OH

300 N NMe Q1b CH2 Me bond NH O a bond Q3a OH

301 N NMe Q1b CH2 H a bond NH S NH Q3a OH

302 N NMe Q1b CH2 H a bond NH S a bond Q3a OH

303 N NMe Q1b CH2 H a bond NH O NH Q3a OH

304 N NMe Q1b CH2 H a bond NH O a bond Q3a OH

305 N S Q1a CH2 Me bond NH S NH Q3a OH

306 N S Q1a CH2 Me bond NH S a bond Q3a OH

307 N S Q1a CH2 Me bond NH O NH Q3a OH

308 N S Q1a CH2 Me bond NH O a bond Q3a OH

309 N S Q1a CH2 H a bond NH S NH Q3a OH

310 N S Q1a CH2 H a bond NH S a bond Q3a OH

311 N S Q1a CH2 H a bond NH O NH Q3a OH

312 N S Q1a CH2 H a bond NH O a bond Q3a OH

313 N S Q1b CH2 Me bond NH S NH Q3a OH

314 N S Q1b CH2 Me bond NH S a bond Q3a OH

315 N S Q1b CH2 Me bond NH O NH Q3a OH

316 N S Q1b CH2 Me bond NH O a bond Q3a OH

317 N S Q1b CH2 H a bond NH S NH Q3a OH

318 N S Q1b CH2 H a bond NH S a bond Q3a OH

319 N S Q1b CH2 H a bond NH O NH Q3a OH

320 N S Q1b CH2 H a bond NH O a bond Q3a OH

321 N O Q1a CH2 Me bond NH S NH Q3a OH

322 N O Q1a CH2 Me bond NH S a bond Q3a OH

323 N O Q1a CH2 Me bond NH O NH Q3a OH

324 N O Q1a CH2 Me bond NH O a bond Q3a OH

325 N O Q1a CH2 H a bond NH S NH Q3a OH/p>

326 N O Q1a CH2 H a bond NH S a bond Q3a OH

327 N O Q1a CH2 H a bond NH O NH Q3a OH

328 N O Q1a CH2 H a bond NH O a bond Q3a OH

329 N O Q1b CH2 Me bond NH S NH Q3a OH

330 N O Q1b CH2 Me bond NH S a bond Q3a OH

331 N O Q1b CH2 Me bond NH O NH Q3a OH

332 N O Q1b CH2 Me bond NH O a bond Q3a OH

333 N O Q1b CH2 H a bond NH S NH Q3a OH

334 N O Q1b CH2 H a bond NH S a bond Q3a OH

335 N O Q1b CH2 H a bond NH O NH Q3a OH

336 N O Q1b CH2 H a bond NH O a bond Q3a OH

337 CH NMe Q1a CH2 Me bond NH S NH Q3a OH

338 CH NMe Q1a CH2 Me bond NH S a bond Q3a OH

339 CH NMe Q1a CH2 Me bond NH O NH Q3 OH

340 CH NMe Q1a CH2 Me bond NH O a bond Q3a OH

341 CH NMe Q1a CH2 H a bond NH S NH Q3a OH

342 CH NMe Q1a CH2 H a bond NH S a bond Q3a OH

343 CH NMe Q1a CH2 H a bond NH O NH Q3a OH

344 CH NMe Q1a CH2 H a bond NH O a bond 3a OH

345 CH NMe Q1b CH2 Me bond NH S NH Q3a OH

346 CH NMe Q1b CH2 Me bond NH S a bond Q3a OH

347 CH NMe Q1b CH2 Me bond NH O NH Q3a OH

348 CH NMe Q1b CH2 Me bond NH O a bond Q3a OH

349 CH NMe Q1b CH2 H a bond NH S NH Q3a OH

350 CH NMe Q1b CH2 H a bond NH S a bond Q3a OH

351 CH NMe Q1b CH2 H a bond NH O NH Q3a OH

352 CH NMe Q1b CH2 H a bond NH O a bond Q3a OH

353 CH S Q1a CH2 Me bond NH S NH Q3a OH

354 CH S Q1a CH2 Me bond NH S a bond Q3a OH

355 CH S Q1a CH2 Me bond NH O NH Q3a OH

356 CH S Q1a CH2 Me bond NH O a bond Q3a OH

357 CH S Q1a CH2 H a bond NH S NH Q3a OH

358 CH S Q1a CH2 H a bond NH S a bond Q3a OH

359 CH S Q1a CH2 H a bond NH O NH Q3a OH

360 CH S Q1a CH2 H a bond NH O a bond Q3a OH

361 CH S Q1b CH2 Me bond NH S NH Q3a OH

362 CH S Q1b CH2 Me bond NH S a bond Q3a OH

363 CH S Q1b CH2 Me bond NH O NH Q3a OH

364 CH S Q1b CH2 Me bond NH O a bond Q3a OH

365 CH S Q1b CH2 H a bond NH S NH Q3a OH

366 CH S Q1b CH2 H a bond NH S a bond Q3a OH

367 CH S Q1b CH2H bond NH O NH Q3a OH

368 CH S Q1b CH2 H a bond NH O a bond Q3a OH

369 CH O Q1a CH2 Me bond NH S NH Q3a OH

370 CH O Q1a CH2 Me bond NH S a bond Q3a OH

371 CH O Q1a CH2 Me bond NH O NH Q3a OH

372 CH O Q1a CH2 Me bond NH O a bond Q3a OH

373 CH O Q1a CH2 H a bond NH S NH Q3a OH

374 CH O Q1a CH2 H a bond NH S a bond Q3a OH

375 CH O Q1a CH2 H a bond NH O NH Q3a OH

376 CH O Q1a CH2 H a bond NH O a bond Q3a OH

377 CH O Q1b CH2 Me bond NH S NH Q3a OH

378 CH O Q1b CH2 Me bond NH S a bond Q3a OH

379 CH O Q1b CH2 Me bond NH O NH Q3a OH

380 CH O Q1b CH2 Me bond NH O a bond Q3a OH

381 CH O Q1b CH2 H a bond NH S NH Q3a OH

382 CH O Q1b CH2 H a bond NH S a bond Q3a OH

383 CH O Q1b CH2 H a bond NH O NH Q3a OH

384 CH O Q1b CH2 H a bond NH O a bond Q3a OH

385 CMe NMe Q1a CH2 Me bond NH S NH Q3a OH

386 CMe NMe Q1a CH2 Me bond NH S a bond Q3a OH

387 CMe NMe Q1a CH2 Me bond NH O NH Q3a OH

388 CMe NMe Q1a CH2 Me bond NH O a bond Q3a OH

389 CMe NMe Q1a CH2 H a bond NH S NH Q3a OH

390 CMe NMe Q1a CH2 H a bond NH S a bond Q3a OH

391 CMe NMe Q1a CH2 H a bond NH O NH Q3a OH

392 CMe NMe Q1a CH2 H a bond NH O a bond Q3a OH

393 CMe NMe Q1b CH2 Me bond NH S NH Q3a OH

394 CMe NMe Q1b CH2 Me bond NH S a bond Q3a OH

395 CMe NMe Q1b CH2 Me bond NH O NH Q3a OH

396 CMe NMe Q1b CH2 Me bond NH O a bond Q3a OH

397 CMe NMe Q1b CH2 H a bond NH S NH Q3a OH

398 CMe NMe Q1b CH2 H a bond NH S a bond Q3a OH

399 CMe NMe Q1b CH2 H a bond NH O NH Q3a OH

400 CMe NMe Q1b CH2 H a bond NH O a bond Q3a OH

401 CMe S Q1a CH2 Me bond NH S NH Q3a OH

402 CMe S Q1a CH2 Me bond NH S a bond Q3a OH

403 CMe S Q1a CH2 Me bond NH O NH Q3a OH

404 CMe S Q1a CH2 Me bond NH O a bond Q3a OH

405 CMe S Q1a CH2 H a bond NH S NH Q3a OH

406 CMe S Q1a CH2 H a bond NH S a bond Q3a OH

407 CMe S Q1a CH2 H a bond NH O NH Q3a OH

408 CMe S Q1a CH2 H a bond NH O St the z Q3a OH

409 CMe S Q1b CH2 Me bond NH S NH Q3a OH

410 CMe S Q1b CH2 Me bond NH S a bond Q3a OH

411 CMe S Q1b CH2 Me bond NH O NH Q3a OH

412 CMe S Q1b CH2 Me bond NH O a bond Q3a OH

413 CMe S Q1b CH2 H a bond NH S NH Q3a OH

414 CMe S Q1b CH2 H a bond NH S a bond Q3a OH

415 CMe S Q1b CH2 H a bond NH O NH Q3a OH

416 CMe S Q1b CH2 H a bond NH O a bond Q3a OH

417 CMe O Q1a CH2 Me bond NH S NH Q3a OH

418 CMe O Q1a CH2 Me bond NH S a bond Q3a OH

419 CMe O Q1a CH2 Me bond NH O NH Q3a OH

420 CMe O Q1a CH2 Me bond NH O a bond Q3a OH

421 CMe O Q1a CH2 H a bond NH S NH Q3a OH

422 CMe O Q1a CH2 H a bond NH S a bond Q3a OH

423 CMe O Q1a CH2 H a bond NH O NH Q3a OH

424 CMe O Q1a CH2 H a bond NH O a bond Q3a OH

425 CMe O Q1b CH2 Me bond NH S NH Q3a OH

426 CMe O Q1b CH2 Me bond NH S a bond Q3a OH

427 CMe O Q1b CH2 Me bond NH O NH Q3a OH

428 CMe O Q1b CH2 Me bond NH O a bond Q3a OH

429 CMe O Q1b CH2 H a bond NH S NH Q3a OH

430 CMe O Q1b CH2 H a bond NH S a bond Q3a OH

431 CMe O Q1b CH2 H a bond NH O NH Q3a OH

432 CMe O Q1b CH2 H a bond NH O a bond Q3a OH

433 N NMe Q1a a bond Me bond NH S CH2 Q3a OH

434 N NMe Q1a a bond Me bond NH O CH2 Q3a OH

435 N NMe Q1a a bond H a bond NH S CH2 Q3a OH

436 N NMe Q1a a bond H a bond NH O CH2 Q3a OH

437 N NMe Q1b a bond Me bond NH S CH2 Q3a OH

438 N NMe Q1b a bond Me bond NH O CH2 Q3a OH

439 N NMe Q1b a bond H a bond NH S CH2 Q3a OH

440 N NMe Q1b a bond H a bond NH O CH2 Q3a OH

441 N S Q1a a bond Me bond NH S CH2 Q3a OH

442 N S Q1a a bond Me bond NH O CH2 Q3a OH

443 N S Q1a a bond H a bond NH S CH2 Q3a OH

444 N S Q1a a bond H a bond NH O CH2 Q3a OH

445 N S Q1b a bond Me bond NH S CH2 Q3a OH

446 N S Q1b a bond Me bond NH O CH2 Q3a OH

447 N S Q1b a bond H a bond NH S CH2 Q3a OH

448 N S Q1b a bond H a bond NH O CH2 Q3a OH

449 N OQ1a link Me bond NH S CH2 Q3a OH

450 N O Q1a a bond Me bond NH O CH2 Q3a OH

451 N O Q1a a bond H a bond NH S CH2 Q3a OH

452 N O Q1a a bond H a bond NH O CH2 Q3a OH

453 N O Q1b a bond Me bond NH S CH2 Q3a OH

454 N O Q1b a bond Me bond NH O CH2 Q3a OH

455 N O Q1b a bond H a bond NH S CH2 Q3a OH

456 N O Q1b a bond H a bond NH O CH2 Q3a OH

457 CH NMe Q1a a bond Me bond NH S CH2 Q3a OH

458 CH NMe Q1a a bond Me bond NH O CH2 Q3a OH

459 CH NMe Q1a a bond H a bond NH S CH2 Q3a OH

460 CH NMe Q1a a bond H a bond NH O CH2 Q3a OH

461 CH NMe Q1b a bond Me bond NH S CH2 Q3a OH

462 CH NMe Q1b a bond Me bond NH O CH2 Q3a OH

463 CH NMe Q1b a bond H a bond NH S CH2 Q3a OH

464 CH NMe Q1b a bond H a bond NH O CH2 Q3a OH

465 CH S Q1a a bond Me bond NH S CH2 Q3a OH

466 CH S Q1a a bond Me bond NH O CH2 Q3a OH

467 CH S Q1a a bond H a bond NH S CH2 Q3a OH

468 CH S Q1a a bond H a bond NH O CH2 Q3a OH

469 CH S Q1b a bond Me bond NH S CH2 Q3a OH

470 CH S Q1b a bond Me bond NH O CH2 Q3a OH

471 CH S Q1b a bond H a bond NH S CH2 Q3a OH

472 CH S Q1b a bond H a bond NH O CH2 Q3a OH

473 CH O Q1a a bond Me bond NH S CH2 Q3a OH

474 CH O Q1a a bond Me bond NH O CH2 Q3a OH

475 CH O Q1a a bond H a bond NH S CH2 Q3a OH

476 CH O Q1a a bond H a bond NH O CH2 Q3a OH

477 CH O Q1b a bond Me bond NH S CH2 Q3a OH

478 CH O Q1b a bond Me bond NH O CH2 Q3a OH

479 CH O Q1b a bond H a bond NH S CH2 Q3a OH

480 CH O Q1b a bond H a bond NH O CH2 Q3a OH

481 CMe NMe Q1a a bond Me bond NH S CH2 Q3a OH

482 CMe NMe Q1a a bond Me bond NH O CH2 Q3a OH

483 CMe NMe Q1a a bond H a bond NH S CH2 Q3a OH

484 CMe NMe Q1a a bond H a bond NH O CH2 Q3a OH

485 CMe NMe Q1b a bond Me bond NH S CH2 Q3a OH

486 CMe NMe Q1b a bond Me bond NH O CH2 Q3a OH

487 CMe NMe Q1b a bond H a bond NH S CH2 Q3a OH

488 CMe NMe Q1b a bond Swazi NH O CH2 Q3a OH

489 CMe S Q1a a bond Me bond NH S CH2 Q3a OH

490 CMe S Q1a a bond Me bond NH O CH2 Q3a OH

491 CMe S Q1a a bond H a bond NH S CH2 Q3a OH

492 CMe S Q1a a bond H a bond NH O CH2 Q3a OH

493 CMe S Q1b a bond Me bond NH S CH2 Q3a OH

494 CMe S Q1b a bond Me bond NH O CH2 Q3a OH

495 CMe S Q1b a bond H a bond NH S CH2 Q3a OH

496 CMe S Q1b a bond H a bond NH O CH2 Q3a OH

497 CMe O Q1a a bond Me bond NH S CH2 Q3a OH

498 CMe O Q1a a bond Me bond NH O CH2 Q3a OH

499 CMe O Q1a a bond H a bond NH S CH2 Q3a OH

500 CMe O Q1a a bond H a bond NH O CH2 Q3a OH

501 CMe O Q1b a bond Me bond NH S CH2 Q3a OH

502 CMe O Q1b a bond Me bond NH O CH2 Q3a OH

503 CMe O Q1b a bond H a bond NH S CH2 Q3a OH

504 CMe O Q1b a bond H a bond NH O CH2 Q3a OH

505 N NMe Q1a a bond Me the link CH2 S bond Q3a OH

506 N NMe Q1a a bond Me the link CH2 S NH Q3a OH

507 N NMe Q1a a bond Me the link CH2 O bond Q3a OH

508 N NMe Q1a a bond Me the link CH2 O NH Q3a OH

509 N NMe Q1a a bond H a bond CH2 S bond Q3a OH

510 N NMe Q1a a bond H a bond CH2 S NH Q3a OH

511 N NMe Q1a a bond H a bond CH2 O bond Q3a OH

512 N NMe Q1a a bond H a bond CH2 O NH Q3a OH

513 N NMe Q1b a bond Me the link CH2 S bond Q3a OH

514 N NMe Q1b a bond Me the link CH2 S NH Q3a OH

515 N NMe Q1b a bond Me the link CH2 O bond Q3a OH

516 N NMe Q1b a bond Me the link CH2 O NH Q3a OH

517 N NMe Q1b a bond H a bond CH2 S bond Q3a OH

518 N NMe Q1b a bond H a bond CH2 S NH Q3a OH

519 N NMe Q1b a bond H a bond CH2 O bond Q3a OH

520 N NMe Q1b a bond H a bond CH2 O NH Q3a OH

521 N S Q1a a bond Me the link CH2 S bond Q3a OH

522 N S Q1a a bond Me the link CH2 S NH Q3a OH

523 N S Q1a a bond Me the link CH2 O bond Q3a OH

524 N S Q1a a bond Me the link CH2 O NH Q3a OH

525 N S Q1a a bond H a bond CH2 S bond Q3a OH

526N S Q1a a bond H a bond CH2 S NH Q3a OH

527 N S Q1a a bond H a bond CH2 O bond Q3a OH

528 N S Q1a a bond H a bond CH2 O NH Q3a OH

529 N S Q1b a bond Me the link CH2 S bond Q3a OH

530 N S Q1b a bond Me the link CH2 S NH Q3a OH

531 N S Q1b a bond Me the link CH2 O bond Q3a OH

532 N S Q1b a bond Me the link CH2 O NH Q3a OH

533 N S Q1b a bond H a bond CH2 S bond Q3a OH

534 N S Q1b a bond H a bond CH2 S NH Q3a OH

535 N S Q1b a bond H a bond CH2 O bond Q3a OH

536 N S Q1b a bond H a bond CH2 O NH Q3a OH

537 N O Q1a a bond Me the link CH2 S bond Q3a OH

538 N O Q1a a bond Me the link CH2 S NH Q3a OH

539 N O Q1a a bond Me the link CH2 O bond Q3a OH

540 N O Q1a a bond Me the link CH2 O NH Q3a OH

541 N O Q1a a bond H a bond CH2 S bond Q3a OH

542 N O Q1a a bond H a bond CH2 S NH Q3a OH

543 N O Q1a a bond H a bond CH2 O bond Q3a OH

544 N O Q1a a bond H a bond CH2 O NH Q3a OH

545 N O Q1b a bond Me the link CH2 S bond Q3a OH

546 N O Q1b a bond Me the link CH2 S NH Q3a OH

547 N O Q1b a bond Me the link CH2 O bond Q3a OH

548 N O Q1b a bond Me the link CH2 O NH Q3a OH

549 N O Q1b a bond H a bond CH2 S bond Q3a OH

550 N O Q1b a bond H a bond CH2 S NH Q3a OH

551 N O Q1b a bond H a bond CH2 O bond Q3a OH

552 N O Q1b a bond H a bond CH2 O NH Q3a OH

553 CH NMe Q1a a bond Me the link CH2 S bond Q3a OH

554 CH NMe Q1a a bond Me the link CH2 S NH Q3a OH

555 CH NMe Q1a a bond Me the link CH2 O bond Q3a OH

556 CH NMe Q1a a bond Me the link CH2 O NH Q3a OH

557 CH NMe Q1a a bond H a bond CH2 S bond Q3a OH

558 CH NMe Q1a a bond H a bond CH2 S NH Q3a OH

559 CH NMe Q1a a bond H a bond CH2 O bond Q3a OH

560 CH NMe Q1a a bond H a bond CH2 O NH Q3a OH

561 CH NMe Q1b a bond Me the link CH2 S bond Q3a OH

562 CH NMe Q1b a bond Me the link CH2 S NH Q3a OH

563 CH NMe Q1b a bond Me the link CH2O bond Q3a OH

564 CH NMe Q1b a bond Me the link CH2 O NH Q3a OH

565 CH NMe Q1b a bond H a bond CH2 S bond Q3a OH

566 CH NMe Q1b a bond H a bond CH2 S NH Q3a OH

567 CH NMe Q1b a bond H a bond CH2 O bond Q3a OH

568 CH NMe Q1b a bond H a bond CH2 O NH Q3a OH

569 CH S Q1a a bond Me the link CH2 S bond Q3a OH

570 CH S Q1a a bond Me the link CH2 S NH Q3a OH

571 CH S Q1a a bond Me the link CH2 O bond Q3a OH

572 CH S Q1a a bond Me the link CH2 O NH Q3a OH

573 CH S Q1a a bond H a bond CH2 S bond Q3a OH

574 CH S Q1a a bond H a bond CH2 S NH Q3a OH

575 CH S Q1a a bond H a bond CH2 O bond Q3a OH

576 CH S Q1a a bond H a bond CH2 O NH Q3a OH

577 CH S Q1b a bond Me the link CH2 S bond Q3a OH

578 CH S Q1b a bond Me the link CH2 S NH Q3a OH

579 CH S Q1b a bond Me the link CH2 O bond Q3a OH

580 CH S Q1b a bond Me the link CH2 O NH Q3a OH

581 CH S Q1b a bond H a bond CH2 S bond Q3a OH

582 CH S Q1b a bond H a bond CH2 S NH Q3a OH

583 CH S Q1b a bond H a bond CH2 O bond Q3a OH

584 CH S Q1b a bond H a bond CH2 O NH Q3a OH

585 CH O Q1a a bond Me the link CH2 S bond Q3a OH

586 CH O Q1a a bond Me the link CH2 S NH Q3a OH

587 CH O Q1a a bond Me the link CH2 O bond Q3a OH

588 CH O Q1a a bond Me the link CH2 O NH Q3a OH

589 CH O Q1a a bond H a bond CH2 S bond Q3a OH

590 CH O Q1a a bond H a bond CH2 S NH Q3a OH

591 CH O Q1a a bond H a bond CH2 O bond Q3a OH

592 CH O Q1a a bond H a bond CH2 O NH Q3a OH

593 CH O Q1b a bond Me the link CH2 S bond Q3a OH

594 CH O Q1b a bond Me the link CH2 S NH Q3a OH

595 CH O Q1b a bond Me the link CH2 O bond Q3a OH

596 CH O Q1b a bond Me the link CH2 O NH Q3a OH

597 CH O Q1b a bond H a bond CH2 S bond Q3a OH

598 CH O Q1b a bond H a bond CH2 S NH Q3a OH

599 CH O Q1b a bond H a bond CH2 O bond Q3a OH

600 CH O Q1b a bond H with the IDE CH2 O NH Q3a OH

601 CMe NMe Q1a a bond Me the link CH2 S bond Q3a OH

602 CMe NMe Q1a a bond Me the link CH2 S NH Q3a OH

603 CMe NMe Q1a a bond Me the link CH2 O bond Q3a OH

604 CMe NMe Q1a a bond Me the link CH2 O NH Q3a OH

605 CMe NMe Q1a a bond H a bond CH2 S bond Q3a OH

606 CMe NMe Q1a a bond H a bond CH2 S NH Q3a OH

607 CMe NMe Q1a a bond H a bond CH2 O bond Q3a OH

608 CMe NMe Q1a a bond H a bond CH2 O NH Q3a OH

609 CMe NMe Q1b a bond Me the link CH2 S bond Q3a OH

610 CMe NMe Q1b a bond Me the link CH2 S NH Q3a OH

611 CMe NMe Q1b a bond Me the link CH2 O bond Q3a OH

612 CMe NMe Q1b a bond Me the link CH2 O NH Q3a OH

613 CMe NMe Q1b a bond H a bond CH2 S bond Q3a OH

614 CMe NMe Q1b a bond H a bond CH2 S NH Q3a OH

615 CMe NMe Q1b a bond H a bond CH2 O bond Q3a OH

616 CMe NMe Q1b a bond H a bond CH2 O NH Q3a OH

617 CMe S Q1a a bond Me the link CH2 S bond Q3a OH

618 CMe S Q1a a bond Me the link CH2 S NH Q3a OH

619 CMe S Q1a a bond Me the link CH2 O bond Q3a OH

620 CMe S Q1a a bond Me the link CH2 O NH Q3a OH

621 CMe S Q1a a bond H a bond CH2 S bond Q3a OH

622 CMe S Q1a a bond H a bond CH2 S NH Q3a OH

623 CMe S Q1a a bond H a bond CH2 O bond Q3a OH

624 CMe S Q1a a bond H a bond CH2 O NH Q3a OH

625 CMe S Q1b a bond Me the link CH2 S bond Q3a OH

626 CMe S Q1b a bond Me the link CH2 S NH Q3a OH

627 CMe S Q1b a bond Me the link CH2 O bond Q3a OH

628 CMe S Q1b a bond Me the link CH2 O NH Q3a OH

629 CMe S Q1b a bond H a bond CH2 S bond Q3a OH

630 CMe S Q1b a bond H a bond CH2 S NH Q3a OH

631 CMe S Q1b a bond H a bond CH2 O bond Q3a OH

632 CMe S Q1b a bond H a bond CH2 O NH Q3a OH

633 CMe O Q1a a bond Me the link CH2 S bond Q3a OH

634 CMe O Q1a a bond Me the link CH2 S NH Q3a OH

635 CMe O Q1a a bond Me the link CH2 O bond Q3a OH

636 CMe O Q1a a bond Me with the IDE CH2 O NH Q3a OH

637 CMe O Q1a a bond H a bond CH2 S bond Q3a OH

638 CMe O Q1a a bond H a bond CH2 S NH Q3a OH

639 CMe O Q1a a bond H a bond CH2 O bond Q3a OH

640 CMe O Q1a a bond H a bond CH2 O NH Q3a OH

641 CMe O Q1b a bond Me the link CH2 S bond Q3a OH

642 CMe O Q1b a bond Me the link CH2 S NH Q3a OH

643 CMe O Q1b a bond Me the link CH2 O bond Q3a OH

644 CMe O Q1b a bond Me the link CH2 O NH Q3a OH

645 CMe O Q1b a bond H a bond CH2 S bond Q3a OH

646 CMe O Q1b a bond H a bond CH2 S NH Q3a OH

647 CMe O Q1b a bond H a bond CH2 O bond Q3a OH

648 CMe O Q1b a bond H a bond CH2 O NH Q3a OH

649 CMe NH Q1a NH Me bond NH S NH Q3a OH

650 CMe NH Q1a NH Me bond NH S a bond Q3a OH

651 CMe NH Q1a NH Me bond NH O NH Q3a OH

652 CMe NH Q1a NH Me bond NH O a bond Q3a OH

653 CMe NH Q1a NH H a bond NH S NH Q3a OH

654 CMe NH Q1a NH H a bond NH S a bond Q3a OH

655 CMe NH Q1a NH H a bond NH O NH Q3a OH

656 CMe NH Q1a NH H a bond NH O a bond Q3a OH

657 CMe NH Q1b NH Me bond NH S NH Q3a OH

658 CMe NH Q1b NH Me bond NH S a bond Q3a OH

659 CMe NH Q1b NH Me bond NH O NH Q3a OH

660 CMe NH Q1b NH Me bond NH O a bond Q3a OH

661 CMe NH Q1b NH H a bond NH S NH Q3a OH

662 CMe NH Q1b NH H a bond NH S a bond Q3a OH

663 CMe NH Q1b NH H a bond NH O NH Q3a OH

664 CMe NH Q1b NH H a bond NH O a bond Q3a OH

665 CMe NH O Q1a Me bond NH S NH Q3a OH

666 CMe NH O Q1a Me bond NH S a bond Q3a OH

667 CMe NH O Q1a Me bond NH O NH Q3a OH

668 CMe NH O Q1a Me bond NH O a bond Q3a OH

669 CMe NH Q1a O H a bond NH S NH Q3a OH

670 CMe NH Q1a O H a bond NH S a bond Q3a OH

671 CMe NH Q1a O H a bond NH O NH Q3a OH

672 CMe NH Q1a O H a bond NH O a bond Q3a OH

673 CMe NH O Q1b Me bond NH S NH Q3a OH

674 CMe NH O Q1b Me bond NH S a bond Q3a OH

675 CMe NH O Q1b Me bond NH O NH Q3a OH

676 CMe NH O Q1b Me the link NHO bond Q3a OH

677 CMe NH Q1b O H a bond NH S NH Q3a OH

678 CMe NH Q1b O H a bond NH S a bond Q3a OH

679 CMe NH Q1b O H a bond NH O NH Q3a OH

680 CMe NH Q1b O H a bond NH O a bond Q3a OH

681 CMe NH Q1a CH2 Me bond NH S NH Q3a OH

682 CMe NH Q1a CH2 Me bond NH S a bond Q3a OH

683 CMe NH Q1a CH2 Me bond NH O NH Q3a OH

684 CMe NH Q1a CH2 Me bond NH O a bond Q3a OH

685 CMe NH Q1a CH2 H a bond NH S NH Q3a OH

686 CMe NH Q1a CH2 H a bond NH S a bond Q3a OH

687 CMe NH Q1a CH2 H a bond NH O NH Q3a OH

688 CMe NH Q1a CH2 H a bond NH O a bond Q3a OH

689 CMe NH Q1b CH2 Me bond NH S NH Q3a OH

690 CMe NH Q1b CH2 Me bond NH S a bond Q3a OH

691 CMe NH Q1b CH2 Me bond NH O NH Q3a OH

692 CMe NH Q1b CH2 Me bond NH O a bond Q3a OH

693 CMe NH Q1b CH2 H a bond NH S NH Q3a OH

694 CMe NH Q1b CH2 H a bond NH S a bond Q3a OH

695 CMe NH Q1b CH2 H a bond NH O NH Q3a OH

696 CMe NH Q1b CH2 H a bond NH O a bond Q3a OH

697 CMe NH Q1a a bond Me bond NH S CH2 Q3a OH

698 CMe NH Q1a a bond Me bond NH O CH2 Q3a OH

699 CMe NH Q1a a bond H a bond NH S CH2 Q3a OH

700 CMe NH Q1a a bond H a bond NH O CH2 Q3a OH

701 CMe NH Q1b a bond Me bond NH S CH2 Q3a OH

702 CMe NH Q1b a bond Me bond NH O CH2 Q3a OH

703 CMe NH Q1b a bond H a bond NH S CH2 Q3a OH

704 CMe NH Q1b a bond H a bond NH O CH2 Q3a OH

705 CMe NH Q1a link Me link CH2 S bond Q3a OH

706 CMe NH Q1a link Me link CH2 S NH Q3a OH

707 CMe NH Q1a link Me link CH2 O bond Q3a OH

708 CMe NH Q1a link Me link CH2 O NH Q3a OH

709 CMe NH Q1a a bond H a bond CH2 S bond Q3a OH

710 CMe NH Q1a a bond H a bond CH2 S NH Q3a OH

711 CMe NH Q1a a bond H a bond CH2 O bond Q3a OH

712 CMe NH Q1a a bond H a bond CH2 O NH Q3a OH

713 CMe NH Q1b link Me link CH2 S bond Q3a OH

714 CMe NH Q1b link Me link CH2 S NH Q3a OH

715 CMe NH Q1b a bond Me with the IDE CH2 O bond Q3a OH

716 CMe NH Q1b link Me link CH2 O NH Q3a OH

717 CMe NH Q1b a bond H a bond CH2 S bond Q3a OH

718 CMe NH Q1b a bond H a bond CH2 S NH Q3a OH

719 CMe NH Q1b a bond H a bond CH2 O bond Q3a OH

720 CMe NH Q1b a bond H a bond CH2 O NH Q3a OH

--------------------------------------------------

73. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 2 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b and Q3a in table 2 indicate the following placeholders).

74. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

75. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds is of deposits or their solvate (provided in the case of item 75) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

76. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

77. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

78. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and Tj in table 1 mean the following placeholders).

79. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

80. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case of item 80) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

81. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

82. Compounds in which the A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

83. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

84. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

85. Compounds in which A, B, R1L1, R2L2L3, Y, L4, 3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

86. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

87. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

88. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in tables is 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

89. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

90. Compounds in which A, B, R1L1, R2L2L3, Y, L4, R3and X are any of the above in table 1 combinations; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate (provided that in the case p) Q1a, Q1b, Q1c, Q1i, Q1j, T3a, T3b, T3c, T3d, T3e, Q3e, T3f, T3g, T3h, T3i and T3j in table 1 mean the following placeholders).

91. Compounds represented by any of PP)-90), in which X is transformed into NH2; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

92. Compounds represented by any of the C PP)-90), in which X is transformed into SH; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

93. Compounds represented by any of PP)-90), in which X is transformed into OAc; the tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

94. Activators of receptor thrombopoetin represented by any one of items 1)-93).

95. Preventive, therapeutic and improving agents against diseases for which treatment is effective activation of the receptor thrombopoetin that as the active component contains activators of receptor thrombopoetin presented in p) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of these activators or their solvate.

96. Agents that increase the number of platelets containing as an active ingredient activators of receptor thrombopoetin presented in p) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of these activators or their solvate.

97. Drugs, containing as an active ingredient the compound represented by any one of items 1)-93) or the formula (1), tautomers, prodrugs or pharmaceutically acceptable salts of these compounds or their solvate.

In the present invention is connected to the I present invention, represented by formula (1)may be in the form of the tautomers or geometrical isomers, which are industriously or ekzoticheskoy isomerization, mixtures of the tautomers or geometrical isomers or their mixtures. If the compounds of the present invention have an asymmetric center, which either is or is not the result of isomerization, the compounds of the present invention can be in the form of dissolved optical isomers or as mixtures containing a certain ratio of these isomers.

For example, furan compounds, thiophene compounds and pyrrole compounds of the present invention may be present in the form of (4-hydroxy-2(5H)-furanone) analogues of tetronic acid, (4-hydroxy-2(5H)-thiophene) analogues thiotetronic acid and (4-hydroxy-3-pyrrolin-2-one) analogues terminoloy acid, as shown in the diagrams (2), (3) and (4), mixtures thereof or mixtures of their isomers.

Compounds of the present invention represented by the formula (1)or their pharmaceutically acceptable salts can be in arbitrary crystalline form or in any form of hydrates, depending on the conditions of reception. In the scope of the present invention includes crystals, hydrates and mixtures thereof. They can be in the form of a solvate with an organic solvent, such as is ceton, ethanol and tetrahydrofuran, and the scope of the present invention includes any of these forms.

Compounds of the present invention represented by the formula (1)can be converted into a pharmaceutically acceptable salt or, if necessary, can be selected from the salts obtained. Pharmaceutically acceptable salts of the present invention may constitute, for example, alkali metal salts (such as lithium, sodium and potassium), alkaline earth metals (such as magnesium and calcium), ammonium, organic bases and amino acids. They can be a salt of inorganic acid (such as hydrochloric acid, Hydrobromic acid, phosphoric acid and sulfuric acid) and organic acids (such as acetic acid, citric acid, maleic acid, fumaric acid, benzolsulfonat acid and p-toluensulfonate acid).

Compounds that function as prodrugs, are derivatives of the present invention, which has a chemically or metabolically degradable group, which give the pharmacologically active compounds of the present invention when the solvolysis or under physiological conditions in vivo. Methods for isolating or obtaining the appropriate prodrugs are disclosed, for example, in the Design of Prodrug (Elsevier, Amsterdam 1985). In the present invention, if the connection is hydroc the ilen group, acrosiphonia obtained by reaction of the compounds with suitable acylhomoserine or suitable acid anhydrides, it can represent, for example, prodrugs. Allocryptopine, particularly preferred as prodrugs include-OCOC2H5, -OCO(t-Bu), -OCOC15H31, -OCO(m-CO2Na-Ph), -OCOCH2CH2CO2Na, -OCOCH(NH2)CH3,-OCOCH2N(CH3)2etc. If the connection of the present invention has an amino group, an amide derivative obtained by the reaction of compounds having the amino group, with suitable halides or suitable mixed halides, can represent, for example, prodrugs. Amides, particularly preferred as prodrugs include-NHCO(CH2)20OCH3, -NHCOCH(NH2)CH3etc. If the compounds of the present invention have a carboxyl group, esters of carboxylic acids with aliphatic alcohols or esters of carboxylic acids obtained by reaction with a free alcoholic hydroxyl group, 1,2 - or 1,3-diglycerides can be, for example, prodrugs. Particularly preferred prodrugs represent methyl ester and complex ethyl esters.

Preventive, therapeutic and improving agents against C the problems treatment which is effective activation of the receptor thrombopoetin, or agents that increase the number of platelets, which contain as the active component activators of receptor thrombopoetin of the present invention, tautomers, prodrugs or pharmaceutically acceptable salts, activators or their solvate, usually you can enter as using drugs for oral administration such as tablets, capsules, powders, granules, pills and syrup, and with the help of medicines for rectal use, medical preparations for percutaneous application or injection. The agents of the present invention can be administered as a single therapeutic agent or as mixtures with other therapeutic agents. Although they can be entered in the form in which they are, they are usually administered in the form of pharmaceutical compositions. These pharmaceutical preparations can be obtained by adding the usual ways pharmacologically and pharmaceutically acceptable additives. Namely, pharmaceutical preparations for oral administration are the usual fillers, slip agents, binders, disintegrators, wetting agents, plasticizers and agents to cover. Liquid preparations for oral administration may be in the form of water or oil is x suspensions, solutions, emulsions, syrups or elixirs, or may be supplied as dry syrups which before use it should be mixed with water or other suitable solvents. Such liquid preparations may contain conventional additives such as suspendresume agents, fragrances, solvents and emulsifiers. In the case of rectal application of the drug can be administered in the form of candles. For candles as a basis you can use a suitable substance, such as cocoa butter beans, lauric oil, macrogol, gelatin-glycerin base, witepsol, sodium stearate and mixtures thereof and, if necessary, candles may contain an emulsifier, suspendisse agent, preservative, etc. In the case of injection to obtain a water dosage forms or dosage forms which before use is necessary to dissolve, you can use such pharmaceutical components, such as distilled water for injection, saline solution, 5%glucose, propylene glycol or other solvents or solubilizing agents, regulators pH, isotherwise agents and stabilizers.

The dose of the agents of the present invention for administration to man is usually from about 0.1 to 1000 mg/person/day in the case of medicinal products for oral or rectal, and from about 0.05 mg d is 500 mg/person/day in the case of injection, adult, although it depends on the age and condition of the patient. The above ranges are only examples, and the dose should be determined depending on the condition of the patient.

The present invention is used when it is expected that the use of compounds which have affinity to the receptor thrombopoetin and act as agonists of the receptor thrombopoetin, improve pathological condition. For example, there can be mentioned, hematological abnormalities, followed by abnormal platelet counts. In particular, it is effective for therapy or prevention of diseases of humans and mammals caused by an abnormal megakaryopoiesis, especially one that is accompanied by thrombocytopenia. Examples of such diseases include thrombocytopenia resulting from chemotherapy or radiotherapy for cancer, thrombocytopenia, resulting in antiviral therapy, as well as cases of diseases such as hepatitis C, thrombocytopenia caused by bone marrow transplantation, surgery, serious infections, or gastrointestinal bleeding, but such diseases are not limited to the above. The agents of the present invention are also designed to treat typical of thrombocytopenia, such as aplastic anemia, idiopathic thrombocytopenic purpura, myelodysplastic Sindh is om, liver disease, HIV infection, and lack of thrombopoetin. The present invention can be used as matters of peripheral stem cell inducer of cell differentiation megakaryoblastic and megakaryocytic leukemia or agent increasing the number of platelets for platelet donors. In addition, potential applications include therapeutic angiogenesis, based on differentiation and proliferation of vascular endothelial cells and endothelial progenitor cells, prevention and therapy of arteriosclerosis, myocardial infarction, unstable angina, occlusive peripheral arteries, without restrictions.

Compounds represented by formula (1), obtained by the process represented by the scheme (5) and illustrated below.

The reaction of the compound (I)- NH2the compound (II) in a solvent, if necessary in the presence of a catalyst, by heating and stirring gives the desired compound or its predecessor. Predecessor, if necessary, can be hydrolyzed, deprived of the protective group, restored or oxidized to the desired connection. Compounds of the present invention can usually be cleaned by column chromatography, thin-layer chromatography are you ecoeffectiveness liquid chromatography (HPLC) or high performance liquid chromatography - mass spectrometry (HPLC/MS) and, if necessary, they can be obtained with high purity by recrystallization or washing with solvents.

In relation to the synthesis of intermediate compounds (I) can be referenced to describe the synthesis of the following heterocyclic compounds:

1) pyrazole (scheme (6))

J. Chem. Soc. Perkin. TransI, p.81 (1985)

2) Isothiazol (scheme (7))

Liebigs. Annalen. der. Chemie., 10, 1534-1546 (1979)

3) Isoxazol (scheme 8))

Synthesis, 10, 664-665 (1975)

4) Thiophene (scheme (9))

JP-A-48-026755

5) Furan (scheme (10))

J. Org. Chem., 21, 1492-1509 (1956) and EP1253146

6) Pyrrole (scheme (11))

J. Heterocyclic Chem., 30, 1253 (1993) and Tetrahedron, 50(26), 7849-56 (1994)

7) Tetronic acid (4-hydroxy-2(5H)-furanone) analogue (scheme (12))

Synthesis, 7, 564-566 (1988) and Yakugaku Zasshi, 96(4), 536-543 (1976)

8) Terminowa acid (4-hydroxy-3-pyrrolin-2-one) analogue (scheme (13))

Synthesis, 2, 190-192 (1987) and Agric. Biol. Chem., 43(8), 1641-1646 (1979)

In respect of synthesis-NH2compounds (II), for example, when L3= NH, you can refer to:

1) L4= bond, Y = O

Synthetic Commun., 28(7), 1223-1231 (1998), J. Chem. Soc., 1225 (1948) and J. Chem. Soc., 2831 (1952)

2) L4= NH, Y = O

J. Am. Chem. Soc., 46, 2813 (1924) and J. Chem. Soc., 2654 (1952)

3) L4= NH, Y = S

Can. J. Chem., 35, 834 (1957)

4) L4= CH2Y = O

J. Org. Chem., 30, 2487 (1965)

5) L4= O, Y = O

Bull. Soc. Chim. Belg., 68, 409 (1959)

Compounds represented by f is rmulas (1), in which L3represents NR19L4represents NH and Y represents O or S, produced by the process represented in the diagram (14) and illustrated below.

Compounds represented by formula (1)in which L3represents NR19L4represents a bond, and Y represents O or S, produced by the process represented in the diagram (15) and is illustrated below.

The reaction of the compound (I) with NH2the compound (IV) in a solvent, if necessary in the presence of a condensing agent or catalyst, by heating and stirring gives compound (III) as the desired product.

EXAMPLES

Below is described the present invention with reference to reference examples, synthesis examples synthesis examples of the analysis and examples of the manufacture of dosage forms. However, it should be noted that the present invention is not restricted to these specific examples.

1H-NMR analysis was performed at 300 MHz and13C-NMR analysis was performed at 75 MHz. LC/MS was measured under the following conditions.

Condition 1 for LC/MS

Column: Waters SunFire C18 (3.5 µm, a 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 30/70)

Condition 2 for LC/MS

Olonka: Waters SunFire C18 (3.5 µm, a 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 60/40)

Condition 3 for LC/MS

Column: Waters SunFire C18 (3.5 µm, a 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 85/15)

Condition 4 for LC/MS

Column: Waters Xterra MSC18 (5 μm, a 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 30/70)

Condition 5 LC/MS

Column: Waters Xterra MSC18 (5 μm, a 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 60/40)

Condition 6 for LC/MS

Column: Waters Xterra MSC18 (5 μm, a 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (10/90 → 85/15)

Condition 7 for LC/MS

Column: Waters Xterra MSC18 (5 μm, a 4.6×50 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (20/80 → 100/0)

Condition 8 for LC/MS

Column: Waters Xterra MSC18 (3.5 µm and 2.1×20 mm)

Eluent: acetonitrile/0.2% aqueous solution of formic acid (20/80 → 90/10)

Conditions 9 for LC/MS

Column: Waters SunFire C18 (3.5 µm, a 4.6×30 mm)

Eluent: acetonitrile/0.1% aqueous formic acid (20/80 → 100/0)

REFERENCE EXAMPLE 1 SYNTHESIS

[2-(pyrrolidin-1-yl)ethyl]-amide 5-(geringerer)thiophene-2-carboxylic acid

Methyl 5-[2-(pyrrolidin-1-yl)ethylcarbamate]-thiophene-2-carboxylate (56 mg, 0.2 mm) in ethanol (2.0 ml) was heated under reflux with hydrazine monohydrate (0.10 ml) for 10 hours and left kladitis is to room temperature, lost in the precipitate solid was collected by filtration, washed with water and dried, obtaining 21 mg of the desired product (yield 38%).

Structure: solid white color

LC/MS (ESI+) m/z 297 [M+1]+

LC/MS (ESI-) m/z 295 [M-1]-

REFERENCE EXAMPLE 2 SYNTHESIS

(Tetrahydrofuran-2-ylmethyl)amide 5-(geringerer)thiophene-2-carboxylic acid

The synthesis was performed in the same manner as in reference example 1 synthesis using methyl 5-[(tetrahydrofuran-2-ylmethyl)carbarnoyl]thiophene-2-carboxylate, receiving 17 mg of the desired product (yield 32%).

Structure: solid white color

LC/MS (ESI+) m/z 270 [M+1]+

LC/MS (ESI-) m/z 268 [M-1]-

REFERENCE EXAMPLE 3 SYNTHESIS

[2-(morpholine-4-yl)ethyl]amide 5-(geringerer)thiophene-2-carboxylic acid

The synthesis was performed in the same manner as in reference example 1 synthesis using methyl 5-[2-(morpholine-4-yl)ethylcarbamate]thiophene-2-carboxylate, receiving 30 mg of the desired product (yield 50%).

Structure: solid white color

LC/MS (ESI+) m/z 299 [M+1]+

LC/MS (ESI-) m/z 297 [M-1]-

REFERENCE EXAMPLE 4 SYNTHESIS

2,5-di(geringerer)thiophene

The synthesis was performed in the same manner as in reference example 1 synthesis using dimethyl thiophene-2, 5-in primary forms, receiving 28 mg of the desired product./p>

Structure: solid pale green color

1H-NMR (DMSO-d6) δ: 4,51 (4H, s), to 7.64 (2H, s), 9,88 (2H, users).

LC/MS (ESI-) m/z 199 [M-1]-

REFERENCE EXAMPLE 5 SYNTHESIS

N-[1-(5-hydrazinecarboxamide-2-carbonyl)pyrrolidin-3-yl]ndimethylacetamide

The synthesis was performed in the same manner as in reference example 1 synthesis using methyl 5-[3-(acetylamino)pyrrolidin-1-carbonyl]thiophene-2-carboxylate, receiving 37 mg of the desired product (yield 62%).

Structure: solid white color

LC/MS (ESI+) m/z 297 [M+1]+

LC/MS (ESI-) m/z 295 [M-1]-

REFERENCE EXAMPLE 6 SYNTHESIS

2-(N',N'-dimethylhydrazinium)-5-(geringerer)thiophene

Methyl 5-(N,N-dimethylhydrazinium)thiophene-2-carboxylate (46 mg, 0.2 mm) in ethanol (2.0 ml) was heated under reflux with hydrazine monohydrate (0.10 ml) for 10 hours and left to cool to room temperature. After adding 3 ml of water the reaction solution was extracted with 10 ml ethyl acetate and the extract was dried over magnesium sulfate, filtered and concentrated, gaining 23 mg of the desired product (yield 50%).

Structure: colorless oil

LC/MS (ESI+) m/z 229 [M+1]+

LC/MS (ESI-) m/z 227 [M-1]-

REFERENCE EXAMPLE 7 SYNTHESIS

tert-Butyl 3-{[5-(geringerer)thiophene-2-carbonyl]amino}propionate

The synthesis was performed in such disposala, as in referential example 1 synthesis using methyl 5-[2-tert-butoxycarbonyl)ethylcarbamate]thiophene-2-carboxylate, receiving 37 mg of the desired product (yield 62%).

Structure: solid white color

LC/MS (ESI+) m/z 314 [M+1]+

LC/MS (ESI-) m/z 312 [M-1]-

REFERENCE EXAMPLE 8 SYNTHESIS

tert-Butyl {[5-(geringerer)thiophene-2-carbonyl]amino}acetate

Methyl 5-(tert-butoxycarbonylmethylene)thiophene-2-carboxylate (63 mg, 0.21 mm) in ethanol (3.0 ml) was heated under reflux with hydrazine monohydrate (0,13 ml) for 8 hours and left to cool to room temperature. The reaction mixture was concentrated under reduced pressure and added water. Precipitated precipitated solid substance was collected by filtration, washed with water and dried, receiving 44 mg of the desired product (71%yield).

Structure: solid white color

LC/MS (ESI+) m/z 300 [M+1]+

LC/MS (ESI-) m/z 298 [M-1]-

REFERENCE EXAMPLE 9 SYNTHESIS

Piperidine-1-alamid 5-(geringerer)thiophene-2-carboxylic acid

Methyl 5-(piperidine-1-ylcarbonyl)thiophene-2-carboxylate (232 mg, 0.87 mm) in ethanol (6.0 ml) was heated under reflux with hydrazine monohydrate (0,40 ml) for 3 hours and left to cool to room temperature, and precipitated precipitated solid substance was collected by filtration, prom is Wali water and dried, getting 129 mg of the desired product (yield 56%).

Structure: solid white color

LC/MS (ESI+) m/z 269 [M+1]+

LC/MS (ESI-) m/z 267 [M-1]-

REFERENCE EXAMPLE 10 SYNTHESIS

(4-methylpiperazin-1-yl)amide 5-(geringerer)thiophene-2-carboxylic acid

Methyl 5-(4-methylpiperazin-1-ylcarbonyl)thiophene-2-carboxylate (218 mg, 0.77 mm) in ethanol (6.0 ml) was heated under reflux with hydrazine monohydrate (0,40 ml) for 6 hours and left to cool to room temperature, the solvent is evaporated at 40ºC. To the obtained oil was added 5 ml of diethyl ether and precipitated precipitated solid substance was collected by filtration, washed with water and dried, getting 142 mg of the desired product (yield 65%).

Structure: solid pale yellow color

LC/MS (ESI+) m/z 284 [M+1]+

LC/MS (ESI-) m/z 282 [M-1]-

REFERENCE EXAMPLE 11 SYNTHESIS

Morpholine-4-alamid 5-(geringerer)thiophene-2-carboxylic acid

Methyl 5-(morpholine-4-ylcarbonyl)thiophene-2-carboxylate (237 mg, 0.87 mm) in ethanol (6.0 ml) was heated under reflux with hydrazine monohydrate (0,40 ml) for 6 hours and left to cool to room temperature, the solvent is evaporated at 40°C. To the obtained oil was added 5 ml of diethyl ether and precipitated precipitated solid substance was collected by filtration, washed with water the th and dried, receiving 160 mg of the desired product (yield 68%).

Structure: solid pale yellow color

LC/MS (ESI+) m/z 271 [M+1]+

LC/MS (ESI-) m/z 269 [M-1]-

REFERENCE EXAMPLE 12 SYNTHESIS

5-[4-(pyrrolidin-1-yl)piperidine-1-carbonyl]thiophene-2-carbohydrazide

Methyl 5-[4-(pyrrolidin-1-yl)piperidine-1-carbonyl]thiophene-2-carboxylate (242 mg, 0.75 mm) in ethanol (7.0 ml) was heated under reflux with hydrazine monohydrate (0,38 ml) for 12 hours and left to cool to room temperature, the solvent is evaporated at 40°C. To the obtained oil was added 5 ml of diethyl ether, and precipitated precipitated solid substance was collected by filtration, washed with water and dried, obtaining 193 mg of the desired product (yield 80%).

Structure: solid pale yellow color

LC/MS (ESI+) m/z 323 [M+1]+

REFERENCE EXAMPLE 13 SYNTHESIS

2-(3,4-dichlorophenyl)-4-(1-hidradenitis)thiophene-3-ol

2-(3,4-dichlorophenyl)-3-hydroxy-4-(methylcarbamyl)thiophene (50 mg, 0.17 mm) (obtained by the method disclosed in WO2004/108683) in isopropanol was stirred with hydrazine monohydrate (95 μl, 0.19 mm) at 90ºC for 1 hour, then left to cool to room temperature and was stirred at 0ºC. Precipitated precipitated solid substance was collected by filtration and dried, obtaining 36 mg of the desired product (yield 69%).

Structure: solid white is the

LC/MS (ESI+) m/z 301 [M+1]+

LC/MS (ESI-) m/z 299 [M-1]-

REFERENCE EXAMPLE 14 SYNTHESIS

3-(1-hidradenitis)-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-ol

1-[4-hydroxy-1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazole-3-yl]alanon (2,72 g to 9.57 mm) (obtained by the method disclosed in WO2004/108683) was dissolved in 1,4-dioxane (82 ml) and was added dropwise hydrazine monohydrate (0,512 ml, 10,53 mm) at 50ºC. The reaction solution was stirred at the same temperature for 3 hours and then left to cool, and added ethyl acetate. The organic layer was three times washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and filtered. The filtrate was dried by evaporation of the solvent, getting 2,90 g of the desired product (yield 102%).

Structure: solid yellow

LC/MS (ESI+) m/z 299 [M+1]+

LC/MS (ESI-) m/z 297 [M-1]-

REFERENCE EXAMPLE 15 SYNTHESIS

Potassium 3-[4-(geringerer)phenyl]-3-hydroxypropionate

15-a) Methyl 4-(2-tert-butoxycarbonyl-1-hydroxyethyl)benzoate

Diisopropylamine (with 0.55 ml, 3.9 mm) was dissolved in dry tetrahydrofuran (10 ml)at 0ºC was added dropwise to 2.66 M n-utility in hexane (1.4 ml, 3.6 mm). The reaction solution was stirred at 0ºC for 10 minutes and was cooled to-78ºC, and then was added dropwise tert-butyl acetate (0,58 ml, 4.3 mm), was stirred at -78 the C for 30 minutes. Methyl 4-formylbenzoate (0,70 g, 4.3 mm) in tetrahydrofuran (6 ml) was added dropwise at-78ºC for more than 5 minutes and the reaction solution was stirred at-78ºC for 10 minutes at 0ºC for 1 h, then acetic acid (of 0.43 ml, 7.5 mm) brought the pH up to 7 and again heated up to room temperature over 12 hours. The solution was concentrated by evaporation of the tetrahydrofuran under reduced pressure, and added ethyl acetate and water. The organic layer was separated and dried to dryness under reduced pressure, obtaining of 1.17 g of the desired crude product. The desired crude product was purified by chromatography on a column of silica gel (Merck silica gel 60, 22 g, n-hexane-ethyl acetate 4:1)to give 0.84 g of the desired product (yield 84%).

Structure: colourless solid

1H-NMR (CDCl3) δ: of 1.45 (9H, s), 2,65 (1H, DD, J=16.5 and a 7.0 Hz), to 2.66 (1H, DD, J=16.5 and 5.5 Hz), 3,66 (1H, d, J=3.5 Hz), 3,91 (3H, s), 5,09-5,17 (1H, m), 7,45 (1H, d, J=8.5 Hz), 8,02 (1H, d, J=8,5 Hz).

15-b) Methyl 4-(2-carboxy-1-hydroxyethyl)benzoate

Methyl 4-(2-tert-butoxycarbonyl-1-hydroxyethyl)benzoate (140 mg, 0.50 mm) was dissolved in triperoxonane acid (2.0 ml)and the resulting solution was left to stand at room temperature for 3 hours and concentrated under reduced pressure to obtain a dry residue, getting 113 mg of the desired product (stoichiometric yield).

Structure: colourless solid

1 H-NMR (DMSO-d6) δ: 2,50 (1H, DD, J=15.5 and 8.5 Hz: overlapped with DMSO), to 2.57 (1H, DD, J=15.5 and 5.0 Hz), 3,82 (3H, s)5,00 (1H, DD, J=8.5 and 5.0 Hz), 5,4-5,8 (1H, users), to 7.50 (1H, d, J=8.0 Hz), to $ 7.91 (1H, d, J=8.0 Hz).

15-c) Potassium 3-[4-(geringerer)phenyl]-3-hydroxypropionate

Methyl 4-(2-carboxy-1-hydroxyethyl)benzoate (110 mg, 0,49 mm) was dissolved in methanol (2.0 ml). Was added 0.1 M potassium hydroxide in methanol (4.9 ml, 0,49 mm) and then at room temperature was added hydrazine monohydrate (of 0.24 ml, 4.9 mm). The resulting solution was left to stand at 45ºC for 1 hour at 60ºC for 2.5 hours, but the flow of the original substance was small. The solution was concentrated under reduced pressure by evaporation of methanol and left to stand in water at 80ºC for 1 hour to complete the reaction. The reaction solution was concentrated to obtain a dry residue, getting the desired crude product.

Structure: colourless solid

1H-NMR (DMSO-d6) δ: 1,93 (1H, DD, J=15,0 and 9.5 Hz), 2,19 (1H, DD, J=15,0 and 3.5 Hz), 4,3-4,6 (2H, users), 4,69 (1H, DD, J=9.5 and 3.5 Hz), 7,35 (1H, d, J=8.0 Hz), 7,71 (1H, d, J=8.0 Hz), 9,67 (1H, users).

REFERENCE EXAMPLES 16-22 SYNTHESIS

The synthesis was performed in the same manner as in reference example 1 synthesis, except that the reference example 18 synthesis was performed in the same manner as in reference example 15, the outputs and the structure of the resulting compounds, the LC/MS conditions used on the I analysis, and the observed peaks and latencies are shown in table 3.

Table 3
No. of sample synthesisOutput (%)StructureConditions LC/MSThe observed peak ESI+The observed peak ESI-Time
delay (min)
16100solid white color83133110,47
1789solid white color
18100solid pale yellow color
1977the amorphous substance of pale yellow color 13002980,48
2050solid white color
2184solid white color22782760,28
2267the amorphous substance of pale yellow color8272 (M-isobutene+1)1,30

REFERENCE EXAMPLES 23-26 SYNTHESIS

The synthesis was performed by the method disclosed in WO2004/108683, output and structure of the obtained compounds, the conditions of LC/MS used for their analysis and the observed peaks and latencies are shown in table 4.

Table 4
No. of sample synthesisStructureConditions LC/MS The observed peak ESI+The observed peak ESI-Delay time (min)
23solid yellow2247245to 4.52
24solid yellow93033013,34
25solid light brown2297/299295/2974,54
26solid pale green color2253/255251/2534,49

REFERENCE EXAMPLE 27 SYNTHESIS

3-(1-Hidradenitis)-1-methyl-5-(3,4-dichlorophenyl)-1H-pyrazole-4-ol

The synthesis was performed in the same manner as in reference example 14 synthesis using 1-[4-hydroxy-1-methyl-5-(3,4-dichlorophenyl)-1H-pyrazole-3-yl]alanon (obtained by the method disclosed in WO 2004/108683)to give 326 mg of the desired product (yield 100%).

Structure: solid is e substance of pale yellow color

1H-NMR (CDCl3) δ: of 2.23 (3H, s), of 3.84 (3H, s), of 5.24 (2H, s), 7,35 (1H, DD, J=8.5 and 2.0 Hz), 7,53 (1H, d, J=8.5 Hz), to 7.61 (1H, d, J=2.0 Hz), 9,01 (1H, users).

REFERENCE EXAMPLE 28 SYNTHESIS

5-[2-(4-Oxo-1,4-dihydropyridines-1-yl)acetyl]thiophene-2-carboxylic acid

1) Synthesis of methyl 5-(2-bromoacetyl)thiophenecarboxylate

1.08 g (5,86 mm) of methyl 5-acetylthiocholine was dissolved in 40 ml of tetrahydrofuran, and the resulting solution was cooled to 0°C and stirred with 2,31 g (6.15 mm) of phenyltrimethylammonium tribromide at room temperature for 24 hours. For completion of the reaction was added to 50 ml of water and the reaction solution was twice extracted with 50 ml ethyl acetate. The organic layer was dried over magnesium sulfate, and then magnesium sulfate was removed by filtration, and the solvent is evaporated, getting 2.20 g of light brown solid. It was recrystallize from a mixture of hexane and 40 ml - 7 ml chloroform, receiving 990 mg of methyl 5-(2-bromoacetyl)thiophenecarboxylate (yield 64%).

Structure: solid light brown

LC/MS (ESI+) m/z 263, 265 [M+1]+

The delay time and 2.79 min (condition 6)

2) Methyl 5-[2-(4-Oxo-1,4-dihydropyridines-1-yl)acetyl]thiophene-2-carboxylate

263 mg of methyl 5-(2-bromoacetyl)thiophenecarboxylate (1.00 mm)obtained in step 1), 100 mg of 4-hydroxypyridine (1,05 mm) and 151 mg of potassium carbonate (1.0 mm) was stirred in 5 ml of methyl ethyl ketone at room temperature during 3 days. After adding 10 ml of water the organic solvent is evaporated and added 20 ml of water. The precipitate was collected by filtration and dried, obtaining 189 mg of methyl 5-[2-(4-oxopyridine-1(4H)-yl)acetyl]thiophene-2-carboxylate (yield 68%).

Structure: solid pale purple

LC/MS (ESI+) m/z 278 [M+1]+

LC/MS (ESI-) m/z 276 [M-1]-

The delay time of 1.53 min (condition 6)

1H-NMR (CDCl3) δ: of 2.08 (3H, s), 5,12 (2H, s), 6,44 (2H, d, J=7,0 Hz), 7,20 (2H, d, J=7,0 Hz), 7,76 (2H, d, J=2.0 Hz), to 7.84 (2H, d, J=2.0 Hz).

13C-NMR (DMSO-d6) δ: 52,9 60,8 117,1 133,6 134,2 139,1 141,9 144,8, 161,2, 176, 187,3.

3) 5-[2-(4-Oxo-1,4-dihydropyridines-1-yl)acetyl]thiophene-2-carboxylic acid

189 mg of Methyl 5-[2-(4-Oxo-1,4-dihydropyridines-1-yl) acetyl]thiophene-2-carboxylate (0.68 mm)obtained in step 2, was dissolved in 15 ml of methanol and mixed with 2.7 ml (4 EQ.) 1M aqueous sodium hydroxide solution at room temperature over night. The reaction solution was cooled to 0°C and neutralized with 2.7 ml of 1M hydrochloric acid, the organic solvent evaporated. Precipitated precipitated solid substance was collected by filtration, washed with 2 ml of water and dried, obtaining 129 mg 5-[2-(4-Oxo-1,4-dihydropyridines-1-yl)acetyl]thiophene-2-carboxylic acid (yield 72%).

Structure: solid red

LC/MS (ESI+) m/z 264 [M+1]+

LC/MS (ESI-) m/z 262 [M-1]-

The delay time of 0.47 min (usl is of 6)

1H-NMR (DMSO-d6) δ: 5,62 (2H, s), of 6.20 (2H, d, J=7,0 Hz), the 7.65 (2H, d, J=7,0 Hz), 7,87 (2H, d, J=2.0 Hz), of 8.06 (2H, d, J=2.0 Hz).

Structures of the compounds obtained in reference examples 16-28 synthesis shown below.

EXAMPLE 1 SYNTHESIS

[2-(Pyrrolidin-1-yl)ethyl]amide 5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carboxylic acid

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (22 mg, 0.075 mm) in dimethyl sulfoxide (2.0 ml) was heated with [2-(pyrrolidin-1-yl)ethyl]amidon 5-(geringerer)thiophene-2-carboxylic acid (21 mg, 0.075 mm)obtained in reference example 1 synthesis at 100°C for 24 hours. Evaporation of the solvent followed by recrystallization from a mixture of chloroform (1 ml) - diethyl ether (2 ml) gave 12 mg of the desired product (yield 29%).

Structure: solid orange color

LC/MS (ESI+) m/z 551, 553 [M+1]+

LC/MS (ESI-) m/z 549, 551 [M-1]-

EXAMPLE 2 SYNTHESIS

(Tetrahydrofuran-2-ylmethyl)amide 5- (2-{1-[5(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carboxylic acid

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (22 mg, 0.075 mm) in isopropanol (2.0 ml) was heated with (tetrahydrofuran-2-ylmethyl)amidon 5-(geringerer)thiophene-2-carboxylic acid (20 mg, 0.075 mm)obtained in reference example 2 synthesis, and 3 mg of the monohydrate of p-toluenesulfonic acid at 105°C for 17 hours and left to cool to room temperature. Precipitated precipitated solid substance was collected by filtration, washed with 1 ml isopropanol and 1 ml of chloroform and dried, obtaining 26 mg of the desired product (yield 72%).

Structure: solid light brown

1H-NMR (DMSO-d6) δ: 1,50-1,70 (1H, m), 1.70 to a 2.00 (4H, m), 3,50-4,10 (3H, m), 7,60-7,80 (2H, m), 7,86 (1H, d, J=4 Hz), 8,00 (1H, d, J=4 Hz), with 8.05 (1H, users), to 8.12 (1H, s), 8,80 (1H, t, J=6 Hz), and 11.4 (1H, s).

LC/MS (ESI+) m/z 538, 540 [M+1]+

LC/MS (ESI-) m/z 536, 538 [M-1]-

EXAMPLE 3 SYNTHESIS

[2-(Morpholine-4-yl)ethyl]amide 5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carboxylic acid

The synthesis was performed in the same manner as in example 1 synthesis using [2-(morpholine-4-yl)ethyl]amide 5-(geringerer)thiophene-2-carboxylic acid obtained in reference example 3 synthesis, receiving 12 mg of the desired product (yield 21%).

Structure: solid white color

1H-NMR (DMSO-d6) δ: 3,5-4,0 (4H, m), and 7.6 to 7.75 (MN, m), 7,80 (1H, d, J=4 Hz), of 7.9 to 8.1 (2H, m), of 8.09 (1H, d, J=2 Hz), 1,4 (1H, C).

LC/MS (ESI+) m/z 567, 569 [M+1]+

LC/MS (ESI-) m/z 565, 567 [M-1]-

EXAMPLE 4 SYNTHESIS

5-(2-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbohydrazide

The synthesis was performed in the same manner as in example 2 synthesis using 2,5-di(geringerer)thiophene obtained in reference example 4 synthesis, receiving 43 mg of the desired product (yield 90%).

Structure: solid pale yellow color

1H-NMR (DMSO-d6) δ: 7,60 to 7.75 (2H, m), to 7.77 (1H, d), of 8.00 (1H, d), with 8.05 (1H, users), 8,13 (1H, s).

LC/MS (ESI+) m/z 469, 471 [M+1]+

LC/MS (ESI-) m/z 467, 469 [M-1]-

EXAMPLE 5 SYNTHESIS

N-{1-[5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl}pyrrolidin-3-yl]ndimethylacetamide

The synthesis was performed in the same manner as in example 2 synthesis using N-[1-(5-hydrazinecarboxamide-2-carbonyl)pyrrolidin-3-yl]acetamide", she obtained in reference example 5 synthesis, receiving 53 mg of the desired product (yield 93%).

Structure: solid pale yellow color

1H-NMR (DMSO-d6) δ: is 1.81 (3H, AC), 2,0-2,3 (1H, m), 3,5-4,2 (4H, m), 4,30 (1H, users), 7,5-7,8 (3H, m), of 7.9 to 8.1 (2H, m)to 8.12 (1H, s), 8,19 (1H, t, J=6 Hz), and 11.5 (1H, s).

LC/MS (ESI+) m/z 565, 567 [M+1]+

LC/MS (ESI-) m/z 563, 565 [M-1]-

EXAMPLE 6 SYNTHESIS

(N',N'-Dimethylhydrazide 5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethyl) - Rev. den}geringerer)thiophene-2-carboxylic acid

The synthesis was performed in the same manner as in example 2 synthesis using 2-(N',N'-dimethylhydrazinium)-5-(geringerer)thiophene obtained in reference example 6 synthesis, receiving 14 mg of the desired product (yield 28%).

Structure: solid pale yellow color

(DMSO-d6) δ: 2,60 (3H, s), 2,62 (3H, s), and 7.6 to 7.75 (2H, m), 7,8-8,2 (4H, m).

LC/MS (ESI+) m/z 497, 499 [M+1]+

LC/MS (ESI-) m/z 495, 497 [M-1]-

EXAMPLE 7 SYNTHESIS

3-{[5-(2-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino}propionic acid

7-a) tert-Butyl 3-{[5-(2-(1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer}thiophene-2-carbonyl] amino}propionate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (24 mg, 0,083 mm) in isopropanol (2.0 ml) was heated with tert-butyl 3-{[5-(geringerer)thiophene-2-carbonyl]amino}propionate (18 mg, 0,057 mm)obtained in reference example 7 synthesis, and 6 mg of the monohydrate of p-toluenesulfonic acid at 100°C for 8 hours and left to cool to room temperature. In the reaction mixture was added water, and the precipitated precipitated solid substance was collected by filtration, washed with water, methanol and chloroform and dried, obtaining 28 mg of the desired product (yield 85%).

Structure: solid pale yellow color

LC/MS (ESI-) m/z 580, 582 [M-1]-

7-b) 3-{[5-(2-{1-[5-(3,4-Dichl henyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino)propionic acid

The synthesis was performed in the same manner as in example 8 synthesis using tert-butyl 3-{[5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino}propionate, receiving 14 mg of the desired product (yield 55%).

Structure: solid pale yellow color

1H-NMR (DMSO-d6) δ: 2,40-2,60 (5H, m, overlapped with DMSO), of 3.45 (2H, DD, J=12,3, 6,7 Hz), 7,66 (1H, d, J=8.6 Hz), of 7.70 (1H, DD, J=8,6, 2.0 Hz), 7,80 (1H, d, J=4.0 Hz), 8,00 (1H, d, J=4.0 Hz), with 8.05 (1H, users), to 8.12 (1H, s), 8,80 (1H, t, J=5.4 Hz), 11,44 (1H, s).

LC/MS (ESI+) m/z 526, 528 [M+1]+

LC/MS (ESI-) m/z 524, 526 [M-1]-

EXAMPLE 8 SYNTHESIS

{[5-(2-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino}acetic acid

8-a) tert-Butyl {[5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl] amino}acetate

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (49 mg, 0.17 mm) in isopropanol (2.0 ml) was heated with tert-butyl {[5-(geringerer)thiophene-2-carbonyl]amino}acetate (44 mg, 0.15 mm)obtained in reference example 8 synthesis, and 3 mg of the monohydrate of p-toluenesulfonic acid at 100°C for 8 hours and left to cool to room temperature. In the reaction mixture was added water, and the precipitated precipitated solid substance was collected by filtration, washed with water, methanol and chloroform and dried, receiving 69 mg is Elenovo product (yield 83%).

Structure: solid pale yellow color

LC/MS (ESI-) m/z 566, 568 [M-1]-

8-b), {[5-(2-{1-[5-(3,4-Dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino}acetic acid

tert-Butyl {[5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carbonyl]amino}acetate (69 mg, 0.12 mmol) in CH2Cl2(4.0 ml) was stirred with triperoxonane acid (0,14 ml) at room temperature for 4 days. The reaction mixture was concentrated under reduced pressure and added chloroform. Precipitated precipitated solid substance was collected by filtration, washed with chloroform and dried, receiving 35 mg of the desired product (yield 56%).

Structure: solid pale yellow color

1H-NMR (DMSO-d6) δ: 2,48 (3H, s, overlapped with DMSO), to 3.92 (2H, userd, J=5.8 Hz), the 7.65 (1H, d, J=8.5 Hz), 7,68 (1H, userd, J=8.5 Hz), 7,86 (1H, d, J=3.8 Hz), 8,03 (1H, d, J=3.8 Hz), with 8.05 (1H, users), 8,13 (1H, s), 9,11 (1H, t, J=5.8 Hz), of $ 11.48 (1H, s).

LC/MS (ESI+) m/z 512, 514 [M+1]+

LC/MS (ESI-) m/z 510, 512 [M-1]-

EXAMPLE 9 SYNTHESIS

Piperidine-1-alamid 5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carboxylic acid

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (29 mg, 0.1 mm) in dimethyl sulfoxide (4.0 ml) was heated with piperidine-1-Alameda 5-(geringerer)thiophene-2-carboxylic acid (2 mg, 0.1 mm)obtained in reference example 9 synthesis at 100°C for 20 hours and left to cool to room temperature. Was added 2 ml of water, and precipitated precipitated solid substance was collected by filtration, washed with 1 ml of chloroform and dried, receiving 47 mg of the desired product (yield 87%).

Structure: solid yellow

LC/MS (ESI+) m/z 537, 539 [M+1]+

LC/MS (ESI-) m/z 535, 537 [M-1]-

EXAMPLE 10 SYNTHESIS

(4-Methylpiperazin-1-yl)amide 5-(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophene-3-yl]ethylidene}geringerer)thiophene-2-carboxylic acid

2-(3,4-Dichlorophenyl)-3-hydroxy-4-methylcarbonate (29 mg, 0.1 mm) in dimethyl sulfoxide (4.0 ml) was heated with (4-methylpiperazin-1-yl)amidon 5-(geringerer)thiophene-2-carboxylic acid (28 g, 0.1 mm)obtained in reference example 10 synthesis at 100°C for 20 hours and left to cool to room temperature. Was added 2 ml of water, and precipitated precipitated solid substance was collected by filtration, washed with 1 ml of chloroform and dried, receiving 50 mg of the desired product (yield 93%).

Structure: solid pale orange color