Dihydrate of iron (ii) hydroascorbate riboflavinate for improving growth and development of chickens

FIELD: agriculture.

SUBSTANCE: invention relates to a novel compound - dihydrate of iron (II) hydroascorbate riboflavinate

(II) Fe(C6H7O6)(C17H19O6N4)2H2O which is used as an additive.

EFFECT: improved development and growth of chickens.

1 cl, 1 ex, 1 tbl


The invention relates to new chemical compounds used to improve the growth and development of chickens.

This compound can be applied in poultry, in particular, as feeding a growing chickens.

In the practice of feeding birds use various additives to improve its growth and development. Of particular importance among these compounds are vitamins, particularly Riboflavin and ascorbic acid.

It is known that Riboflavin (vitamin b2included redox enzymes, which affect the metabolism of proteins, fats, nucleic acids and some vitamins - Pantothenic, folic and orotovoy acids, choline and pyrodoxine, it also provides the normal function of sexual glands and the nervous system [1].

Vitamin C participates in redox processes, in the transformations of nucleic acids in the synthesis of steroid hormones in the adrenal cortex, in education reference proteins (collagen) and proteins of the connective tissue, promotes the formation and accumulation of glycogen in the liver, stimulates the secretion of gastric glands, activates a number of enzymes that affect the metabolism of sulfur [2, 3].

Also known additives for poultry, representing complex compounds of iron and copper with Riboflavin and alpha-amino acids [4] and gamma-aminobutyric acid [5]. For example, note the imposition of the most effective of these compounds of iron complex with Riboflavin and gamma-aminobutyric acid in the feeding of young birds allows you to increase the gain in live weight of chickens by 11.6%.

Has not previously been described compound of iron with ascorbic acid and Riboflavin, suitable as additives in the diet when feeding birds.

The invention is directed to the synthesis of compounds of the dihydrate of hydrobromination iron (II)to extend the range of dietary supplements designed to improve the development and growth of chickens.

The invention is a dihydrate hydrobromination - laminat iron (II), has the following formula: Fe(C6H7O6)(C17H19O6N4)·2H2O and is intended to improve the growth and development of chickens.

Named the invention dehydrate hydrobromination iron (II) was prepared as follows.

0.5 liter of 0.2 n sodium hydroxide solution is dissolved 18,81 g Riboflavin and 8,80 g of ascorbic acid. In the resulting solution contribute to 13.9 g semimodule of ferrous sulfate (FeSO4·7H2O) and the formed slurry is maintained at a temperature of 70-80°C under mechanical stirring for 5-6 hours before moving yellow suspension in light brown. The finished product is filtered, washed with water until a negative reaction to sulfate ions and dried in a drying Cabinet at a temperature of 100-110°C.

The compound is obtained as an amorphous light brown powder, in which the course is 89%.

Connection odourless, non-hygroscopic, stable during storage, solubility 0,362 g in 100 g of water, little soluble in ethanol and insoluble in organic solvents (benzene, chloroform, and others). In neutral and slightly alkaline aqueous solution of the compound barely breaks down into simple components.

When analyzing the connection is found, wt.%: Fe - 8,66, 43,12, N - Br4.61, 34,96, N - 8,65, C17H19O6N4- 58,52,6H7About6- 27,09, N2On - 5,73.

Calculated, wt.%: Fe - 8,72 - 42,99, N - 4,67, 34,89, N - 8,72, C17H19O6N4- 58,41,6H7About6- 27,25, N2On - 5,62.

The calculated molar mass of compound 642, temperature dehydration 135°C. at 220°C, the compound decomposes without melting.

The IR spectrum of Riboflavin are intense bands with frequencies 1740 and 1648 cm-1characteristic frequencies of its carbonyl group νSt(C(4)=O) and νas(C(4)=O), and the absorption band of medium intensity νas(N(5)O-n) frequency 3214 cm-1. In the IR spectrum of compound has no absorption bands with frequencies 3214, 1740 and 1648 cm-1that proves coordinatie Riboflavin with iron ions(P) in deprotonated enol form, with the formation of chelate cycle due to the heteroatom of nitrogen (N(5)and neighboring enol ( (4)) oxygen atom. In the spectrum of Riboflavin also has absorption lines related to the condensed cycles (ν(C=C)=1620, ν(C=N)=1580, ν(Carene.-N=1247, σ(=C-H)arene=882 cm-1), which are observed with a small offset in the IR spectrum of compound (1605, 1578, 1255 and 873 cm-1respectively.

The IR spectrum of ascorbic acid have absorption bands related to the stretching vibrations of C=O groups ((νco=1730), deformation vibrations of the Oh-group at C(2)-atom (δ(he)=1320 cm-1and when With(3)-atom ascorbic acid (δ(he)=1220 cm-1). In the IR spectrum of compound strip deformation vibrations of the Oh-group at C(2)-atom shift in the high frequency region (1330 cm-1), which indicates the coordination of the oxygen atom of this group with a metal ion, and there is no band, related to the deformation vibrations of the Oh-group at C(3)-atom ascorbic acid (δ(he)=1220 cm-1), due to the ionization of this group and formation of Fe-O.

The individuality of the obtained compounds was confirmed by TLC with chromatographytandem in the system ISO-butyl alcohol - formic acid - water (5:1:1). Compound forms on the chromatogram individual spot, the value of Rf=0,15 which differs from RfRiboflavin, ascorbic acid and the compounds with iron (II), with Rfin the interval 0,22-0,57.

The data of chemical analysis, IR spectroscopy and TLC allow to ascribe to the compound of the following structural formula:

Action dihydrate of hydrobromination iron(II) was studied in chickens pullets of laying hens of the cross "Hisexs brown" at the age of 30 days within 1 month on four groups of chickens 100 animals each, formed on the principle of analogues (table).

GroupCf. live weight at the beginning, gThe average live weight at the end, gThe average increase in live weight, gThe average increase in live weight, %
Experienced 1319692373109,1
Experienced 2314705391114,3
Experienced 3316702386of 112.8

The first group was the control, i.e. as a feed received only the basic diet In the diet of the second, third and fourth groups instead Riboflavin, part of the feed, respectively, were injected additive complex compounds at the rate of 5, 10 and 15 mg per 1 kg of feed. The safety population in the control and experimental groups during the test was 100%.

Adding complex compounds of iron, Riboflavin and ascorbic acid in the basic diet instead of Riboflavin has a positive effect on the growth and development of Chicks and leads to an increase in their body weight 9.1-14.3 per cent compared with a control group that did not receive this connection.

Thus, studies have shown that a new connection dehydrate hydrobromination iron (II) is an effective additive that increases the gain of chickens to 14.3%, while the complex compound of iron, Riboflavin and gamma-aminobutyric acid increases the gain in live weight of chickens only 11.6%.

Sources of information

1. Jortner B.S., Cherry J. Peripheral neuropathy of dietary riboflavin defi ciency in chickens //Journal of neuropathology and Experimental neurology - 1987. - V.46. - N 5. - P.544-555.

2. Davis, M., Austin, J., Patridge D. The Vitamin Is. Chemistry and biochemistry. - M.: Mir, 1999. - 176 S.

3. Brake J. Pardue, S.L. Role of ascorbic acid in poultry nutrition // Proc. of 10th Europ. Poultry conf. - Ierusalem, 1998. - P.63-67.

4. Hooks Century, Kryvtsov Century Gamma-aminobutyric acid in the diet of Chicks /Poultry. - 1990. No. 2. - P.21-22.

5. Friedman AT New biologically active compounds and prospects for their use, " Izv. An Kirg. SSR, Chemical engineering science. - 1988. No. 4. - P.21-27.

6. Kebets A.P., Kebets NM Trihydrate gamma aminoethylethanolamine iron (II)intended for the improvement and growth of Chicks. Patent for invention No. 2246848 EN, IPC7AC 1/00, 1/16. Publ. 27.02.2005. Bull. No. 6.

Dehydrate hydrobromination iron (II) formula Fe(C6H7O6)(C17H19O6N4)2H2O designed to improve growth and development of Chicks.


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4 ex, 1 tbl

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2 tbl

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