Method of restoring reducing with age cell growth of tissues (tissue rejuvenation)

FIELD: medicine.

SUBSTANCE: invention relates to experimental medicine and deals with restoration of reducing with age potential of cell growth of tissues in old laboratory animals. For this purpose medication "Transfer-factor" is introduced to laboratory animals in dose corresponding to 1 capsule a day per 50 kg of weight.

EFFECT: method ensures activation of T-lymphocyte function and restoration of potential of cell growth of salivary gland tissues in said group of animals.

 

The invention relates to the fields of biology and medicine.

Analogs of the invention has: all currently used tools anti-aging" can't pay the most important, Central to the process of aging is a decline with age pack of tissues by the division and growth of cells (a sharp decline with the age of the potential of cell growth).

Offered to restore declining with age, the capacity of the cellular tissue growth (rejuvenation of tissues) to use immunotropic drug "transfer Factor"derived from cow colostrum and restoring a number of indicators of immunity, reduced as a result of various reasons; a drug used in foreign practice for medicinal purposes in various diseases with immune deficiency are not directly associated with the aging process.

The way to restore declining with age, the capacity of the cellular tissue growth (rejuvenation of tissues) is that for the treatment of age-related changes in tissues used the drug "transfer factor" in a dose of 1-3 capsules per weight of 60-80 kg (doses correspond to the standard recommendations for use of the drug in chronic diseases of different nature).

Example 1. EFFECTS OF TRANSFER FACTOR IN AGED MICE.

Mice Balb/c, females (6 test old and 6 experienced, as well as 12 young control), in TRUSTe 12 months, introduced TF dissolved in physiological solution, 1 time a day for 1 week. at a dose similar to that used in humans (1 capsule per 50 kg of body weight).

As a test potential of cell growth used hyperplastic reaction of the tissue of the salivary glands on isoproterenol, known as "the phenomenon of Selye (increase in weight after 24 hours).

Investigated also the weight of thymus and spleen, the amount of mononuclear cells from the spleen in the density gradient ficoll 1,09 (lymphocytes + And-cells) and density 1,065 (activated cells of the spleen with lower density)and the number of A-cells in the spleen (adhering to the surface of a plastic Petri dish).

It was shown that if young mice introduction of isoproterenol causes an increase in the mass of the salivary glands 1.5-1.65 times, in old animals is observed in all cases, the mass reduction of the salivary glands on the introduction of isoproterenol (6-26%) from the mean in the control group of animals).

Introduction TF restored the capacity of cell growth in aged mice all animals on isoproterenol an increase in the mass of the salivary glands in a 1.46-1.56 times.

At the same time dramatically (several times) increased the number of activated spleen cells, as well as decreased reaction thymus (weight) on the stress on the introduction of adrenomimetic - Sopater is Nola. Observed number of positive changes And cells.

Thus, TF stabilized and activated the function of T-lymphocytes old animals and restored cell growth potential of tissue that is the most promising of the known effects in Anti-Ageing Medicine" (new industry - "Medicine anti-aging"), and also creates the possibility of activating cell growth in various pathological processes in order to healing tissues - bone (fractures), wound healing (including operating), lung tissue (pneumonia) and other

The way to restore declining with age, the capacity of cell growth in tissues of the salivary glands in the experiment, characterized in that laboratory animals injected the drug "transfer factor" in a dose corresponding to 1 capsule per day per 50 kg of body weight.



 

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