Lipase-containing composition and bleaching catalyst

FIELD: chemistry.

SUBSTANCE: present invention relates to a composition which contains lipase, and a bleaching catalyst which can accept an oxygen atom from a peroxy acid and transfer the oxygen atom to an oxidisable substrate.

EFFECT: less bad smell which arises when using lipase enzymes in detergents.

13 cl, 4 tbl, 3 ex

 

The technical field

The present invention relates to compositions containing a lipase and a catalyst for the bleaching. More specifically, the present invention relates to compositions containing a lipase and a bleaching catalyst, able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate. The compositions of the present invention are typically suitable for use in detergent compositions for washing and have a good cleaning efficiency and low profile unpleasant smell, especially when the problematic contaminants residues in dairy products.

Prior art

Creating a feeling of shabbiness of contamination, such as contamination from the body and other hydrophobic contamination, including contamination of dairy products, with very great difficulty removed from the fabric during washing. The emergence in the 1980-ies lipase enzymes suitable for use in detergents (e.g., Lipolase and Lipolase Ultra, from the company Novo Nordisk is now Novozymes), creates for developers new opportunities to improve removal of fat. Lipase enzymes catalyze the hydrolysis of triglycerides, which constitute the major component of many widespread grease, such as the secretion of sebaceous glands, animal fats (e.g. lard, melted fat, oil is) and vegetable oils (e.g., olive oil, sunflower oil, peanut oil). However, these enzymes are of limited effectiveness in the first cycle of washing (being effective mainly at the stage of extraction of the washing process) and cause the appearance after washing unpleasant smell. Not wishing to be bound by theory, we can note that the unpleasant smell caused by fatty acids, hydrolysis of fats, and is particularly noticeable when the contamination of dairy products such as milk, cream, butter and yogurt; dairy fats contain triglycerides, functionalityand short-chain (e.g., With4) fatty acyl chains that after lipolysis release malodorous volatile fatty acids. General overview of the use of lipase in solid detergents for washing the following link: Enzymes in Detergency, ed. J.H. van Her et al., Vol.69, Marcel Dekker Surfactant Series, Marcel Dekker, New York, 1997, pp 93-132 (ISBN 0-8247-9995-X).

The last time was adjusted industrial production of so-called lipases first wash cycle, such as Lipoprime™ and Lipex™ (Novozymes), which have efficiency at the initial cycle of washing. The enzyme Lipex™ is described in more detail in WO 00/60063 and US 6939702 B1 (Novozymes). The composition of detergents for washing containing enzyme Lipex™, described in more detail in IP.com. publication IP 6443D (Novozymes). However, for the best use of lipase technology is stetsa the need to improve both the profile of fragrances for residual contamination of dairy products, and the effectiveness of cleaning difficult stains.

Manufacturers of detergents also tried to include the bleach catalysts, especially oxaziridine or oxaziridine-forming catalysts whitening, in their detergents to ensure a good efficiency of bleaching. EP 0728181, EP 0728182, EP 0728183, EP 0775192, US 4678792, US 5045223, US 5047163, US 5360568, US 5360569, US 5370826, US 5442066, US 5478357, US 5482515, US 5550256, US 5653910, US 5710116, US 5760222, US 5785886, US 5952282, US 6042744, WO 95/13351, WO 95/13353, WO 97/10323, WO 98/16614, WO 00/42151, WO 00/42156, WO 01/16110, WO 01/16263, WO 01/16273, WO 01/16274, WO 01/16275, WO 01/16276, WO 01/16277 belong to detergent compositions containing oxazolidinone and/or oxaziridine-forming catalysts whitening.

A need remains in the detergent compositions for washing, which have good public profile, clean, good efficiency bleach in cold water, good efficiency of cleaning grease and reduced profile unpleasant odor when the residual fat contamination, especially contamination of dairy products.

The inventors have discovered that the use of lipase in combination with a bleaching catalyst, able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate, improves cleaning efficiency of the detergent composition, at the same time supports bonigen the th profile unpleasant odor when the residual fatty impurities, especially the contamination of dairy products.

In another variant embodiment of the present invention the inventors have discovered that improved profile compatibility with a rubber hose for pumping water when diacyl - and/or tetrachlorosilane materials are used in combination with a lipase.

In a particularly preferred variant of the embodiment of the present invention the inventors have discovered that the use of lipase in combination with (i) a catalyst for the bleaching able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate, and (ii) diacyl - and/or tetrachlorosilane materials significantly improves cleaning efficiency of the composition, reduces the profile of the unpleasant odor of the composition and improves the profile of the compatibility of the composition with a rubber hose for pumping water.

The invention

In the first variant embodiment of the present invention provides a composition comprising: (i) the lipase and (ii) a bleaching catalyst, able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate.

In the second variant embodiment of the present invention provides a composition comprising: (i) the lipase and (ii) diacyl - and/or tetrachlorosilane materials.

A detailed description of the invention

the song

The composition includes: (i) the lipase and (ii) a bleaching catalyst, able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate. Lipase and bleaching catalyst described in more detail below.

The composition may be suitable for use as a detergent composition for washing, the composition of the additive to the washing composition means for washing dishes or compositions for cleaning hard surfaces. The composition typically is a detergent composition. The composition may be a composition for treatment of tissue. Preferably the composition is a detergent composition for washing.

The composition may be in any form such as liquid or solid, although preferably the composition is in solid form. A typical composition is dispersed form, such as sinter, powder obtained by spray drying the extrudate, flakes, needles, ribbon products, granules or any combination thereof. The composition may be in the form of condensed dispersed material, such as the form of tablets or tiles. The composition may be in any other uniform dosage form, such as the shape of the bag, where the composition is typically at least partially, preferably by sushestvovaniju, surrounded by a water-soluble film such as polyvinyl alcohol. Preferably the composition is in the form of a free flowing dispersion of the material; in the form of free flowing dispersed material is typically meant that the composition is in the form of separate discrete particles. The composition may be manufactured by any suitable method, including agglomeration, spray drying, extrusion, mixing, mixing in the dry state, application of a liquid spray, compaction rollers, spheronization, tableting or any combination of them.

The composition typically has a bulk density of from 450 to 1000 g/l, preferably detergent compositions with low bulk density have a bulk density of from 550 to 650 g/l, and preferably detergent compositions of high bulk density have a bulk density from 750 to 900 g/l Composition may also have a bulk density of from 650 to 750 g/l In the washing process, the composition typically is put into contact with water for the formation of a washing solution having a pH of from above 7 to below 13, preferably from above 7 to above 10.5. This is the optimal pH value to ensure a good cleaning while providing a good profile of fabric care.

Preferably the composition includes: (i) from 0% to less than 10%, preferably up to 7% or 4%, or 1%, or 1.5%, by weight of the composition, those who ratetraditionally and/or oxybenzenesulfonate bleaching activators. Most preferably, the composition essentially contains no tetraacetylethylenediamine and/or oxybenzenesulfonate bleaching activators. "Essentially does not contain" typically means "does not specifically included". Maintaining minimum levels of these types of bleaching activators keeps good safety profile compositions for coloring.

Preferably in contact with water the composition forms a wash solution having a pH of from 7 to 10.5. Compositions having such a profile of reserve alkalinity and pH profile, have a good profile stability of lipase.

Preferably the composition comprises from 0%, or 1%, or 2%, or 3%, or 4%, or from 5% to 30%, or 20%, or 10%, by weight of the composition, the source of the carbonate anion. The above source levels carbonate anion provide for the composition good overall cleaning performance and good efficiency of bleaching.

Preferably the composition includes an inhibitor of migration of the dye. Suitable inhibitors transfer dye selected from the group consisting of polyvinylpyrrolidone, preferably having a mass-average molecular weight of from 40000 to 80000 Yes, preferably from 50000 to 70000 Yes; polyvinylimidazole, preferably having a mass-average molecular weight of from 10,000 to 40,000 Da, preferably from 15,000 to 25,000 Da; polyvinyle the one-N-oxide polymer, preferably having a mass-average molecular weight of 30,000 to 70,000 Da, preferably from 40000 to 60000 Yes; copolymer of vinylpyrrolidone and of vinylimidazole, preferably having a mass-average molecular weight of 30,000 to 70,000 Da, preferably from 40000 to 60000 Yes; and combinations thereof. Compositions containing an inhibitor of migration of the dye, are additionally superior safety profile for dye.

The composition may include from 0% to less than 5%, preferably up to 4%, or 3%, or 2%, or even up to 1%, by weight of the composition, of zeolite a main component. Although the composition may include zeolite a main component at 5% wt. or more preferably the composition comprises less than 5 wt.%. zeolite a main component. For compositions may be preferred essentially not contain zeolite main component. "Essentially not containing zeolite main component" typically means that the composition does not contain specifically included zeolite main component. This is especially preferred in cases where the composition is a solid detergent composition for washing and for the composition, it is desirable to have a very high solubility to minimize the amount of water-insoluble residues (which, for example, can be deposited on the surface of the LC is neither), and when it is desirable to obtain a transparent wash solution. Suitable zeolite main components include zeolite A, zeolite X, zeolite p, zeolite MAP.

The composition may include from 0% to less than 10%, or less than 5%, preferably up to 4%, or 3%, or 2%, or even up to 1%, by weight of the composition, of phosphate of the main component. Although the composition may include phosphate main component at 10% wt. or more preferably the composition comprises less than 10 wt.%. phosphate base component. The composition may even be preferred essentially not contain phosphate of the main component. "Essentially not containing phosphate main component" typically means that the composition does not contain a specially added phosphate main component. It is particularly preferred if the composition is desirable to have a very good profile of environmental safety. Suitable phosphate basic components include sodium tripolyphosphate.

The composition may include from 0% to less than 5%, or preferably up to 4%, or 3%, or even up to 2%, or 1%, by weight of the composition, of silicate salt. Although the composition may include a silicate salt at 5% wt. or more preferably the composition comprises less than 5 wt.%. silicate salt. The composition may even be preferred essentially n which contain silicate salt. "Essentially not containing silicate salt" typically means that the composition does not contain a specially added silicate salt. This is especially preferred in cases where the composition is a solid detergent composition for washing and it is desirable to ensure that the composition had a very good profile dispersive ability of the pigment and solubility, and to ensure that the composition was made clear cleaning solution when dissolved in water. Silicate salts include water-insoluble silicate salts. Silicate salts also include amorphous silicate salts and crystalline layered silicate salt (for example, SKS-6). Silicate salts include sodium silicate.

The composition typically includes an auxiliary ingredients. These auxiliary ingredients include detergent surfactants, such as anionic detergent surfactants, nonionic detergent surfactants, cationic detergent surfactants, zwitterionic detergent surfactants, amphoteric detergent surfactants; the preferred anionic detergent surfactants are alkoxysilane anionic detergent surfactants, such as linear or branched, substituted or unsubstituted C12-18-al is illconceived sulfates, with medium alkoxysilane from 1 to 30, preferably from 1 to 10, preferably a linear or branched, substituted or unsubstituted C12-18-alkylalkoxysilane sulphate having an average degree of amoxilonline from 1 to 10, most preferably unsubstituted linear C12-18-alkylalkoxysilane sulphate having an average degree of amoxilonline from 3 to 7, in other preferred anionic detergent surfactants are the alkyl sulphates, alkyl sulphonates, alkylphosphate, alkylphosphonate, alkylcarboxylic or any mixture of those preferred include alkyl sulphates linear or branched, substituted or unsubstituted C10-18the alkyl sulphates, other preferred anionic detergent surface-active agent is C10-13line Las; preferred nonionic detergent surfactants are C8-18-alkylalkoxysilane alcohols having an average degree of alkoxysilane from 1 to 20, preferably from 3 to 10, most preferred are C12-18-alkylalkoxysilane alcohols having an average degree of alkoxysilane from 3 to 10; preferred cationic detergent surfactants are mono - C6-18-alkylaminocarbonyl-Quaternary the Quaternary ammonium chlorides, more preferred is mono-C8-10-alkylaminocarbonyl-Quaternary ammonium chloride, mono-C10-12-alkylaminocarbonyl-Quaternary ammonium chloride and mono-C10-alkylaminocarbonyl-Quaternary ammonium chloride; a source of peroxide oxygen, such as percarbonate salt and/or perborate salt, preferably percarbonate sodium and a source of peroxide oxygen is preferably at least partially has a coating, preferably completely covered with opaque ingredient, such as a carbonate salt, a sulfate salt, a silicate salt, borosilicate, or mixtures, including their mixed salts; bleaching activators, such as tetraacetylethylenediamine, oxybenzenesulfonate bleaching activators, such as nonanoyloxybenzenesulfonate, caprolactamate bleaching activators, kidnie bleaching activators, such as N-nonanoyl-N-methylacetamide; enzymes, such as amylase, arabinose, xylanase, galactans, glucanase, carbohydrase, cellulase, laccase, oxidase, peroxidase, protease, glucanase, spectacles and mannanase, especially preferred are proteases; panagsama system, such as panagsama supplements based on silicones; fluorescent whitening agents; fotoatelier; salt-fillers such the AK sulfate salt, preferably the sodium sulfate; agents softening tissue, such as clay, silicone and/or Quaternary ammonium compounds, especially preferred is montmorillonite clay, optionally, in combination with silicone; flocculants such as polyethylene oxide; inhibitors of migration of the dye, such as polyvinylpyrrolidone, poly-4-vinylpyridine-N-oxide and/or a copolymer of vinylpyrrolidone and vinylimidazole; components, ensuring the integrity of the tissue, such as hydrophobically modified cellulose and oligomers produced by the condensation of imidazole and epichlorohydrin; dispersants pollution and auxiliary means to prevent re-deposition of contaminants, such as alkoxysilane polyamine and ethoxylated ethyleneimine polymers; components, preventing re-deposition of contaminants, such as carboxymethyl cellulose and polyesters; perfumes; sulfamic acid or its salt; citric acid or its salts, carbonate salts, especially preferred is sodium carbonate; and dyes such as orange dye, blue dye, green dye, purple dye, pink dye, or any mixture.

The second variant of the embodiment of the present invention relates to compositions containing: (i) a lipase, for example, the lipase of the first wash cycle; and (ii) allproxy.

Lipase

The composition comprises a lipase. The inclusion of lipase in the composition improves the washing efficiency. In addition, the combination of a lipase with a bleaching catalyst significantly reduces the profile of the unpleasant odor of the composition.

Typical lipase has a number 3.1.1 Classification of enzymes (EC), especially 3.1.1.3, as defined by the EU classification, IUPAC-IUBMB.

Preferably the composition includes lipase in the amount of at least 0.5 mg, preferably at least 0.7 mg, or at least 1.0 mg, or at least 1.5 mg, or at least 2.0 mg, or even at least 3.0 mg, or at least 5.0 mg, or even at least 10 mg of active lipase, 100 g of the composition. Lipase may include a calcium-binding site. Lipase may also exhibit improved stability and/or activity, especially activity in the presence of high levels of free calcium cations that may be present in the washing solution. This is especially preferred in cases when the composition contains low levels of zeolite main component and a phosphate base component.

Typical lipase EC 3.1.1.3 include described in WO 00/60063, WO 99/42566, WO 97/04078, WO 97/04079, US 5869438 and US 6939702 B1. Preferred lipases are produced by Absidia reflexa. Absidia corymbefera, Rhizmucor miehei, Rhizopus delemar, Aspergillus niger, Aspergillus tubigensis, Fusarium oxysporum, Fusarium heterosporum, Aspergillus oryzea, Penicilium camembertii Aspergillus foetidus, Aspergillus niger, Thermomyces lanoginosus (synonym: Humicola lanuginosa) and Landerina penisapora, especially Thermomyces lanoginosus. Are preferred lipase supplied by the company Novozymes under the trade names Lipolase®, Lipolase Ultra®, Lipoprime® and Lipex® (registered trademarks of Novozymes), and LIPASE P "AMANO®" available from Areario Pharmaceutical Co. Ltd., Nagoya, Japan, AMANO-CES®, commercially available from Toa Jozo Co., Tagata, Japan; and further lipase Chromobacter viscosum from US Biochemical Corp., USA. and Diosynth Co., Netherlands, and other lipases, such as Pseudomonas gladioli. Other suitable lipases described in WO 02062973, WO 2004/101759, WO 2004/101760 and WO 2004/101763.

Preferably, the lipase is a polypeptide having an amino acid sequence that: (a) has at least 90% identity with the wild-type lipase isolated from a strain of Humicola lanuginosa DSM 4109; (b) in comparison with the indicated wild-type lipase comprises a substitution of an electrically neutral or negatively charged amino acids on the surface of the three-dimensional structure, located at a distance of not more than 15 of E1 or Q249, positively charged amino acid; and/or (C) includes extension peptide at the C-end; and/or (d) includes extension peptide at the N-the end; and/or (e) meets the following limitations: (i) comprises a negatively charged amino acid in position e the indicated wild-type lipase; and (ii) comprises a negatively charged amino acid in the region corresponding to position the base 90-101 the indicated wild-type lipase; and (iii) include neutral or negatively charged amino acid at the position corresponding to N94 of the indicated wild-type lipase and/or has a negative or neutral total electric charge in the region corresponding to positions 90-101 of the indicated wild-type lipase. The peptide sequence of the wild-type lipase below (sequence ID NO:2).

In one embodiment, the embodiment is suitable lipases include lipases first cycle"described in WO 00/60063 and U.S. patent 6939702 B1, preferably a variant of SEQ ID NO:2, preferably a variant of SEQ ID NO:2 having at least 90% homology with SEQ ID NO:2, containing a substitution of an electrically neutral or negatively charged amino acid at R or at any of positions 3, 224, 229, 231 and 233, and the most preferable variant contains a mutation T231R and N233R, and this most preferred option is sold under the brand name Lipex®.

Other suitable lipases are cutinase and esterase.

A typical composition comprises a lipase in an amount of from 10 to 20000 LU/g, or from 100 to 10,000 LU/g, or even from 500 LU/g or 750 LU/g and up to 3000 LU/g, or up to 1500 LU/g, or up to 1250 LU/year

The catalyst whitening

The catalyst whitening able to accept the oxygen atom from peroxyacids and/or a salt thereof and transfer the oxygen atom oxidizable substrate. Suitable catalysts chill the cation include, without limitation: iminium cations and palimony; iminium zwitterions; modified amines; modified aminoxide; N-sulfonylamide; N-postonline; N-acylamine; thiadiazolidine; performin; cyclic keesara and mixtures thereof.

Suitable iminium cations and palimony include without limitation N-methyl-3,4-dihydroisoquinoline tetrafluoroborate, prepared as described in Tetrahedron (1992), 49(2), 423-38 (see, for example, compound 4, str); N-methyl-3,4-dihydroisoquinoline p-toluensulfonate, prepared as described in U.S. patent 5360569 (see, for example, column 11, Example 1); and N-octyl-3,4-dihydroisoquinoline p-toluensulfonate, prepared as described in U.S. patent 5360568 (see, for example, column 10, Example 3).

Suitable iminium zwitterions include, without limitation, N-(3-sulfopropyl)-3,4-dihydroisoquinoline, inner salt, prepared as described in U.S. patent 5576282 (see, for example, column 31, Example II); N-[2-(sulfoxy)dodecyl]-3,4-dihydroisoquinoline, inner salt, prepared as described in U.S. patent 5817614 (see, for example, column 32, Example V); 2-[3-[(2-ethylhexyl)oxy]-2-(sulfoxy)propyl]-3,4-dihydroisoquinoline, inner salt, prepared as described in WO 05/047264 (see, for example, page 18, Example 8) and 2-[3-[(2-butyloctyl)oxy]-2-(sulfoxy)propyl]-3,4-dihydroisoquinoline, inner salt.

Suitable katal the congestion of oxygen transfer type modified amines include, without limitation, 1,2,3,4-tetrahydro-2-methyl-1-ethynodiol, which can be manufactured in accordance with the procedures described in Tetrahedron Letters (1987), 28(48), 6061-6064. Suitable catalysts for the oxygen transfer type modified aminoxide include, without limitation, 1-hydroxy-N-hydroxy-N-[2-(sulfoxy)decyl]-1,2,3,4-tetrahydroisoquinoline sodium.

Suitable N-sulfonylamino catalysts for oxygen transfer include, without limitation, 3-methyl-1,2-benzisothiazole-1,1-dioxide, prepared according to the procedure described in Journal of Organic Chemistry (1990), 55(4), 1254-61.

Suitable N-Vospominanie catalysts for oxygen transfer include, without limitation, amide [R-(E)]-N-[(2-chloro-5-nitrophenyl)methylene]-P-phenyl-P-(2,4,6-trimetilfenil)phosphinic acid, which can be manufactured in accordance with the procedures described in Journal of Chemical Society, Chemical Communications (1994), (22), 2569-70.

Suitable N-elliminate catalysts for oxygen transfer include, without limitation, [N(E)]-N-(phenylmethylene)ndimethylacetamide, which can be manufactured in accordance with the procedures described in the Polish Journal of Chemistry (2003), 77(5), 577-590.

Suitable thiadiazolidine catalysts for oxygen transfer include, without limitation, 3-methyl-4-phenyl-1,2,5-thiadiazole-1,1-dioxide, which can be manufactured in accordance with the procedures described in U.S. patent 5753599 (column 9, Example 2).

Suitable performanoe catalysts for oxygen transfer include, without limitation, (Z)-2,2,3,3,4,4,4-heptathlon-N-(nonattorney)butanamide fluoride, which can be manufactured in accordance with the procedures described in Tetrahedron Letters (1994), 35(34), 6329-30.

Suitable catalysts for the oxygen transfer type cyclic keosajanom include, without limitation, 1,2:4,5-di-O-isopropylidene-D-Erythro-2,3-hexadiene-2,6-pyranose made in accordance with U.S. patent 6649085 (column 12, Example 1).

Preferably the catalyst whitening includes iminium and/or carbonyl functional group, and typically are capable of forming oxaziridine and/or dioxiranes functional group when akceptowania atom of oxygen, especially when akceptowania oxygen atom from the peroxy acid and/or its salts. Preferably the catalyst whitening includes oxaziridine functional group and/or capable of forming oxaziridine functional group when akceptowania atom of oxygen, especially when akceptowania oxygen atom from peroxyacids and/or its salts. Preferably the catalyst whitening includes cyclic iminium functional group, preferably in the cyclic fragment has a ring size from five to eight atoms (including the nitrogen atom), preferably six atoms, Preferably a bleaching catalyst includes reliminary functional group, preferably bicyclic reliminary functional group, preferably 3,4-dihydroisoquinoline functional group. Typically Eminova functional group is a Quaternary kinoway functional group and typically are capable of forming Quaternary oxaziridine functional group when akceptowania atom of oxygen, especially when akceptowania oxygen atom from peroxyacids and/or its salts. Preferably the bleaching catalyst has a chemical structure corresponding to the following chemical formula

in which n and m independently have values from 0 to 4, preferably n and m are both equal to 0; each R1independently selected from substituted or unsubstituted radical selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl fused aryl, heterocyclic ring-condensed heterocyclic ring, nitro, halogen, cyano, sulfonato, alkoxy, keto, carboxylic, carbalkoxy radicals, and any two vicinal R1the substituents may be combined with the formation of a condensed aryl condensed carbocyclic or condensed heterocyclic ring; each R2independently selected from substituted or unsubstituted p is dikala, independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkaryl, aryl, aralkyl, alkylenes, heterocyclic ring, CNS, arylcarboxylic groups, carboxialkilnuyu groups and amide groups; any R2can be connected with any other R2with the formation of a common ring; any genialny R2can be combined with the formation of carbonyl; and any two of R2can be combined with the formation of the substituted or unsubstituted condensed unsaturated fragment; R3represents C1-C20substituted or unsubstituted alkyl; R4denotes hydrogen or a fragment of Qt-A, where Q denotes a branched or unbranched alkylene, t=0 or 1, and a denotes an anionic group selected from the group consisting of OSO3-, SO3-, CO2-, CCA2-, ORO32-, ORO3H-and ORO2-; R5denotes hydrogen or fragment-CR11R12-Y-Gb-Yc-[(CR9R10)y-O]k-R8where each Y is independently selected from the group consisting of O, S, N-H or N-R8; and each R8independently selected from the group consisting of alkyl, aryl and heteroaryl, and these fragments are substituted or unsubstituted, and, regardless of the fact, whether they are substituted or unsubstituted, these fragments contain less than 21 carbons; each G is independently selected from the group consisting of CO, SO2SO, RHO and RHO2; R9and R10independently selected from the group consisting of N and C1-C4of alkyl; R11and R12independently selected from the group consisting of H and alkyl, or taken together can be connected with the formation of a carbonyl; b=0 or 1; C can = 0 or 1, but must be = 0 if b=0; y denotes an integer from 1 to 6; k denotes an integer from 0 to 20; R6denotes H or alkyl, aryl or heteroaryl fragment; moreover, these fragments are substituted or unsubstituted; and X, if present, is a suitable counterion to balance the charge, preferably X is present when R4denotes hydrogen, and a suitable X include, without limitation, chloride, bromide, sulfate, methosulfate, sulfonate, p-toluensulfonate, Porterfield and phosphate.

In one variant embodiment of the present invention the bleaching catalyst has a structure corresponding to General formula below:

where R is a branched alkyl group containing from three to 24 carbon atoms (including branched carbon atoms) or a linear alkyl group containing from one is about 24 carbon atoms; preferably R13denotes a branched alkyl group containing from eight to 18 carbon atoms, or a linear alkyl group containing from eight to eighteen carbon atoms; preferably R13selected from the group consisting of 2-propylheptyl, 2-butyloctyl, 2-pentylene, 2-hexyldecyl, n-dodecyl, n-tetradecyl, n-hexadecyl, n-octadecyl, isononyl, Isodecyl, isotridecyl and isopentenyl; preferably R13selected from the group consisting of 2-butyloctyl, 2-pentylene, 2-hexyldecyl, isotridecyl and isopentenyl.

Oxybenzenesulfonate and/or oxybenzone activators whitening

The composition preferably includes (i) oxybenzenesulfonate bleaching activators and/or oxybenzone bleaching activators, and (ii) the source of peroxide oxygen. Typically the bleach activator based oksibenzoynoy acid is in salt form. Preferred oxybenzenesulfonate bleaching activators include bleach activators having the General formula:

R-(C=O)-L

where R denotes an alkyl group, optionally branched, containing in cases, when the bleach activator is hydrophobic, from 6 to 14 carbon atoms or from 8 to 12 carbon atoms, and L denotes outgoing group. Examples of suitable waste groups ablauts the benzoic acid and its derivatives, especially its salts. Another particularly preferred waste group is oxybenzenesulfonate. Suitable bleach activators include dodecanesulfonate, technologiessalon, salt technologiesin acid, 3,5,5-trimethylcyclohexylisocyanate, nonanoyloxybenzenesulfonate and nonanoyloxybenzenesulfonate (NOBS). Suitable bleach activators are also disclosed in WO 98/17767. The inclusion of these activators whitening composition is particularly preferable in those cases where the composition contains low levels of zeolite main component and a phosphate base component. The inventors have found that the combination of these activators whitening with peroxide source of oxygen and a catalyst for the bleaching, as described in more detail above, and lipase, particularly in the detergent composition with a low content of basic washing component (such as a detergent composition, including low levels of zeolite main component main component and phosphate), improves the overall washing efficiency, improves compatibility profile with a rubber hose for pumping water and reduces the profile of the unpleasant odor of the composition.

Deciphered

In another variant embodiment, the composition includes: (i) a lipase; and (ii) diacyl - and/or tet is allproxy materials. The inventors have found that these compositions are wonderful compatibility with a rubber hose. It is known that diazepamonline and tetraterpenoids destroy the rubber, such as rubber hoses for pumping water, automatic washing machines, and for numerous washing cycles it can lead to failure of the rubber hose for pumping water. The inventors have found that combining diarilpirimido and/or tetraterpenoids with lipase solves this problem of incompatibility with a rubber hose for pumping water.

Diarylpyrimidine bleaching materials preferably selected from diarilpirimido General formula:

R1-C(O)-OO-(O)C-R2

where R1stands With6-C12-alkyl, preferably6-C12is an alkyl group containing a linear chain with at least 5 carbon atoms, and optionally containing one or more substituents (for example, -N+(CH3)3, -COOH or-CN) and/or one or more plug-in fragments (for example, -CONH-or-CH=CH-), is placed between adjacent carbon atoms of alkyl radical, and R2denotes an aliphatic group, compatible with peroxide fragment, so that R1and R2together contain in General from 8 to 30 carbon atoms. In one preferred aspects the e R 1and R2represent a linear unsubstituted With6-C12is an alkyl chain. Most preferably, R1and R2are identical. Diazepamonline, in which R1and R2both indicate With6-C12-alkyl groups are especially preferred. Preferably at least one, most preferably only one of the R groups (R1and R2does not contain side chains or side ring group in alpha-position or preferably either in the alpha or beta position, or most preferably none of the alpha, or beta, or gamma positions. In another preferred variant of embodiment of the DAP can be asymmetric, so that preferably the hydrolysis of the acyl group R1happened quickly with the formation of percolate, but the hydrolysis of the acyl group R2proceeded slowly.

Tetrachloromethane bleaching materials preferably selected from tetraterpenoids General formula:

R3-C(O)-OO-C(O)-(CH2)n-C(O)-OO-C(O)-R3

where R3represents C1-C9preferably3-C7is an alkyl group, and n denotes an integer from 2 to 12, preferably from 4 to 10, inclusive.

Preferably diacyl - and/or tetrachlorosilane bleaching materials are present in quantities DOS is enough to provide at least 0.5 million -1preferably at least 10 million-1and more preferably at least 50 million-1, the weight of the washing solution. In a preferred variant embodiment of bleaching materials are present in a quantity sufficient to provide from about 0.5 to about 300 million-1preferably from about 30 to about 150 million-1on the weight of the washing solution.

Pre-prepared peroxyacids

Pre-prepared peroxyacids or salts typically are peroxocarbonate acid or its salt or peroxosulfates acid or its salt.

Pre-prepared peroxyacids or salts preferably are, peroxocarbonate acid or its salt, typically having a chemical structure corresponding to the following chemical formula:

in which R14selected from alkyl, Uralkaliy, cycloalkyl, aryl or heterocyclic group; R14can be linear or branched, substituted or unsubstituted; and Y represents any suitable counterion, providing electroneutrality, preferably Y is selected from hydrogen, sodium or potassium. Preferably R14is a linear or branched, substituted or unsubstituted With6-9-Alki the om. Preferably peroxynitrate or its salt selected from peroxyoctanoic acid, peroxidative acid, peroxyoctanoic acid, proxynodename acid, peroxidative acid, any salt or any combinations thereof. Preferably peroxynitrate or her salt has a melting point in the range from 30 to 60°C.

Pre-prepared peroxynitrate or its salt can also be peroxosulphates acid or its salt, typically having a chemical structure corresponding to the following chemical formula:

in which R15selected from alkyl, Uralkaliy, cycloalkyl, aryl or heterocyclic group; R15can be linear or branched, substituted or unsubstituted; and Z represents any suitable counterion, providing electroneutrality, preferably Z is selected from hydrogen, sodium or potassium. Preferably R15represents a linear or branched, substituted or unsubstituted With6-9-alkyl.

EXAMPLES

Example 1: Synthesis of complex mono-[2-(3,4-dihydroisoquinoline-2-yl)-1-(2-ethylhexyloxymethyl)ethyl] ether sulfuric acid, inner salt

Synthesis of 2-Ethylhexylglycerin simple ester: In a flame-dried round bottom flask of 500 ml equipped with a dropping funnel, Zap allenou with epichlorohydrin (15.62 wide g to 0.17 mol), is added 2-ethylhexanol (16.5 g, to 0.127 mol) and tin chloride(4) (0.20 g, 0.001 mol). The reaction is kept under argon atmosphere and heated to 90°C in oil bath. The epichlorohydrin is added dropwise into the stirred solution over 60 minutes, followed by stirring at 90°C for 18 hours. The reaction was equipped with a nozzle for vacuum distillation and 1-chloro-3-(2-ethylhexyloxy)propan-2-ol is distilled at a pressure of 0.2 mm Hg 1-Chloro-3-(2-ethylhexyloxy)propan-2-ol (4,46 g, at 0.020 mol) is dissolved in tetrahydrofuran (50 ml) and stirred at room temperature under argon atmosphere. To the stirred solution was added tert-piperonyl potassium (2,52 g of 0.022 mol) and the suspension is stirred at room temperature for 18 hours. The reaction is then evaporated to a dry residue, the residue is dissolved in hexano and washed with water (100 ml). The hexane phase is separated, dried Na2SO4, filtered and evaporated to a dry residue, give crude 2-Ethylhexylglycerin ether, which can be further purified by vacuum distillation.

The synthesis of complex mono-[2-(3,4-dihydroisoquinoline-2-yl)-1-(2-ethylhexyloxy-methyl)ethyl] ether sulfuric acid, inner salt: In a flame-dried three-neck round bottom flask of 250 ml, equipped with a fridge, an inlet opening for flow of dry argon, a magnetic rod for stirring, a thermometer is m and the heating bath, add 3,4-dihydroisoquinoline (0.40 mol; obtained as described in example 1 of US 5576282), 2-Ethylhexylglycerin ether (0.38 mol, obtained as described above), a complex of SO3-DMF (0.38 mol) and acetonitrile (500 ml). The reaction is heated to 80°C and stirred at this temperature for 72 hours. The reaction is cooled to room temperature, evaporated to a dry residue and the residue is recrystallized from ethyl acetate and/or ethanol, obtaining the desired product. The solvent is acetonitrile can be replaced by other solvents, including, without limitation, 1,2-dichloroethane.

Example 2: Synthesis of complex mono-[2-(3,4-dihydroisoquinoline-2-yl)-1-(2-butylacetoacetate)ethyl] ether sulfuric acid, inner salt

The desired product is obtained in accordance with Example 1, but replacing 2-butyloctyl 2-hexylester.

Example 3: Composition of detergents for washing

The following compositions of detergents for washing - a, b, C and D are suitable for use in the present invention. Typically these compositions are dosed in water at a concentration of from 80 to 120 g/l in the washing process.

Table 1
IngredientAndIn D
The bleaching catalyst, prepared in accordance with example 1 or 20.1% wt.of 0.05% wt.0,03% wt.of 0.05% wt.
Lipase (9 mg/g of the active substance)of 0.15% wt.0,2 wt.%0,3% wt.0,2 wt.%
Linear C12-13-alkylbenzene-sulfonate sodium (LAS)9,0% wt.8% wt.of 7.5% wt.7.0% wt.
Tallowalkyl (TAS)1.0% wt.1.0% wt.
Alkylalkoxysilane C14-15-alcohol with an average degree of amoxilonline 7 (E)2.5% wt.
Sulfate alkylalkoxysilane-s14-15-alcohol with an average degree of amoxilonline 3 (AE3S)4% wt.3,0% wt.2.5% wt.
Mono-C12-14-alkylphenoxy-acidimeter Quaternary ammonium chloride1.5% wt.1.0% wt.
Zeolite 4A15% wt.12,5% wt.
Citric acid3,0% wt.2.0% wt.3,0% wt.3,0% wt.
Percarbonate sodium20% wt.15% wt.17,5% wt.14% wt.
TAED (tetraacetylethylenediamine)2.5% wt.3% wt.2,3% wt.1,6% wt.
NOBS (nonanoyloxybenzenesulfonate)0,0%1.0% wt. 0,0% wt.1.5% wt.
Sodium carbonate20% wt.25% wt.20% wt.25% wt.
Polymeric carboxylate2.0% wt.1.5% wt.3,0% wt.2.5% wt.
The compound having the following General structure: bis((C2H5O)(C2H4O)n)(CH3)-N+-CxH2x-N+-(CH3)-bis((C2H5O)-(C2H4CO)n), where n = from 20 to 30, and x = from 3 to 8, or sulfonated or from sulphonated variants1.0% wt.0,5% wt.0,75% wt.1.0% wt.
Carboxymethylcellulose1.5% wt.1.0% wt.
Other enzymes1.0% wt.0,5% wt.0,75% wt.0,5% wt.
Ethylenediaminetetra acid0,5% wt.0.1%wt.0,2 wt.%of 0.25% wt.
Magnesium sulfate0,75% wt.0,5% wt.1.0% wt.0,5% wt.
Hydroxyethane(methylene-phosphonic acid)0,5% wt.of 0.25% wt.0,2 wt.%0.4% wt.
Fluorescent whitening agent0,2 wt.%0.1% wt.of 0.15% wt.of 0.25% wt.
Silicone defoaming agent0.1% wt.of 0.05% wt.0.1% wt.0.1%wt.
Soap0,5% wt.of 0.25% wt.0,0% wt.0,3% wt.
Fotoatelier 0.01% by wt.0,0001% max.0,0005% max.0,0015% wt.
Flavor1.0% wt.0,5% wt.0,75% wt.0,5% wt.
The sodium sulfate13% wt.15% wt.30% wt.30% wt.
Water and otherup to 100% wt.up to 100% wt.up to 100% wt.up to 100% wt.

The following compositions of detergents for washing - E, F, G and H are suitable for use in the present invention. Typically these compositions are dosed in water at a concentration of from 80 to 120 g/l in the washing process.

Table 2
IngredientEFGN
The bleaching catalyst, prepared in accordance with example 1 or 2 0.01% by wt.of 0.05% wt.
Deciphered2% wt.1% wt.0,5% wt.1% wt.
Lipase (9 mg/g of active enzyme)0,5% wt.0,3% wt.0,2 wt.%0.1% wt.
Linear C12-13-alkylbenzene-sulfonate sodium (LAS)8,0% wt.5,0% wt.of 7.5% wt.7.0% wt.
Sulfate14-15-alkylalkoxysilane alcohol with an average degree of amoxilonline 3 (AE3S)5,0% wt.2.5% wt.a 3.5% wt.6,0% wt.
Citric acid3,0% wt.2.0% wt.5,0% wt.2.5% wt.
Sodium carbonate20% wt.25% wt.22,5% wt. 25% wt.
Polymeric carboxylate2.0% wt.a 3.5% wt.a 3.5% wt.2.5% wt.
The compound having the following General structure: bis((C2H5O)(C2H4O)n)(CH3)-N+-CxH2x-N+-(CH3)-bis((C2H5O)-(C2H4CO)n), where n = from 20 to 30, and x = from 3 to 8 or sulfonated or from sulphonated variants1.0% wt.0,5% wt.0,75% wt.1.0% wt.
Percarbonate sodium0% wt.15% wt.17,5% wt.14% wt.
TAED (tetraacetylethylenediamine)0% wt.3% wt.2,3% wt.1,6% wt.
Carboxymethylcellulose0,5% wt.1.0% wt.1.5% wt.1.0% wt.
Other enzymes1.0% wt 0,5% wt.0,2 wt.%0,5% wt.
Ethylenediaminetetra acidof 0.05% wt.0.1% wt.0,2 wt.%of 0.15% wt.
Magnesium sulfate0,35% wt.0.1% wt.1.0% wt.of 0.25% wt.
Hydroxyethane(methylene-phosphonic acid)0.1% wt.of 0.25% wt.0,2 wt.%0,5% wt.
Fluorescent whitening agent0,2 wt.%0.1% wt.of 0.15% wt.of 0.25% wt.
Silicone defoaming agent0.1% wt.of 0.05% wt.0.1% wt.0,2 wt.%
Soap0,5% wt.of 0.25% wt.1.0% wt.0,5% wt.
Fotoatelier0.01% by wt.0,0001% max.0,0005% max.0,0015% wt.
Flavor1.0% wt.0,5% wt.0,75% wt.0,5% wt.
The sodium sulfate45% wt.30% wt.20% wt.22% wt.
Water and otherup to 100% wt.up to 100% wt.up to 100% wt.up to 100% wt.

The following detergent compositions for Laundry - I, J, K and L are suitable for use in the present invention. Typically these compositions are dosed in water at a concentration of from 20 to 60 g/l in the washing process.

Table 3
IngredientIJToL
The bleaching catalyst, prepared in accordance with example 1 or 2 of 0.15% wt.0,10% wt.0.1% wt.of 0.15% wt.
Deciphered1% wt.0,5% wt.
Lipase0,5% wt.0,3% wt.0.1% wt.0,2 wt.%
Linear C12-13-alkylbenzene-sulfonate sodium (LAS)15% wt.17,5% wt.20% wt.10,0% wt.
Sulfate14-15-alkylalkoxysilane alcohol with an average degree of amoxilonline 3 (AE3S)7.0% wt.of 7.5% wt.5,0% wt.5,0% wt.
Citric acid7.0% wt.5,0% wt.of 7.5% wt.3,0% wt.
Percarbonate sodium20% wt.15% wt.0% wt. 14% wt.
TAED (tetraacetylethylenediamine)2.5% wt.3% wt.0% wt.1,6% wt.
NOBS (nonanoyloxybenzenesulfonate)0,0% wt.2.0% wt.0,0% wt.0% wt.
Sodium carbonate22,5% wt.25% wt.20% wt.10% wt.
Polymeric carboxylate7.0% wt.of 7.5% wt.5,0% wt.3,0% wt.
The compound having the following General structure: bis((C2H5O)(C2H4O)n)(CH3)-N+-CxH2x-N+-(CH3)-bis((C2H5O)-(C2H4CO)n), where n = from 20 to 30, and x = from 3 to 8 or sulfonated or from sulphonated variants2.5% wt.1.5% wt.3,0% wt.1.0% wt.
Carboxymethylcellulose 2.5% wt.3,0% wt.1.5% wt.1.0% wt.
Other enzymes2.5% wt.1.5% wt.3,0% wt.0,75% wt.
Ethylenediaminetetra acidof 0.25% wt.0.1% wt.0,5% wt.of 0.15% wt.
Hydroxyethane(methylene-phosphonic acid)0,5% wt.0,75% wt.of 0.25% wt.0,2 wt.%
Fluorescent whitening agent0,5% wt.0,75% wt.of 0.25% wt.of 0.15% wt.
Silicone defoaming agentof 0.05% wt.0,10% wt.0,02% wt.0,02% wt.
Fotoatelier0,025% wt.0,050% wt.0,02% wt.0,0015% wt.
Water filling (including sodium sulfate) and otherup to 100% wt.up to 100% wt.up to 100% wt.up to 100% wt.

Bleaching detergent compositions in the form of granular detergents for washing is represented by the following formulas. Any of the following compositions are used for washing fabrics at a concentration of 600-10000 million-1in the water, with a typical median conditions 2500 million-1, 25°C and the ratio of water:fabric 25:1. The typical pH of approximately 10, but can be adjusted by changing the ratio of acid and Na-salt of Las.

Table 4
MNOPQR
Line Las202220152020
With12-Dimethylhydroxylamine-ammonium chloride 0,710,00,60,00,7
AE3S0,90,00,90,00,00,9
AE0,00,50,0131
Sodium tripolyphosphate233023171223
Zeolite And0,00,00,00,0100,0
1.6 has been released Silicate777777
Sodium carbonate15 1415181515
Polyacrylate MW 450010,0111,51
Carboxymethylcellulose111111
Savinase 32,89 mg/g0,10,070,10,10,10,1
Natalase 8,65 mg/g0,10,10,10,00,10,1
Lipase 18 mg/g0,030,070,30,10,070,1
Tinopal AMS (company Ciba)0,06 0,00,060,180,060,06
Tinopal CBS-X (Ciba)0,10,060,10,00,10,1
Diethylenetriaminepenta-acetic acid0,60,30,60,250,60,6
MgSO41110,511
Percarbonate sodium0,05,20,10,00,00,0
Fotoatelier0,00300,00150,00150,00200,00450,0010
Perborate on the rija monohydrate 4,40,03,852,090,783,63
NOBS1,90,01,660,00,330,75
TAED0,581,20,510,00,0150,28
Organic catalyst**0,01850,01850,016200,01110,0074
Deciphered***0,51
Sulfate/MoistureUp to 100%Up to 100%Up to 100%Up to 100%Up to 100%Up to 10%
*The lipase is preferably Lipex®.
**Organic catalyst, prepared in accordance with Examples 1 or 2, or mixtures thereof.
***Diarilpirimido preferably is denominated.

The sequence I.D No. 2

All documents cited in the detailed description of the invention, in its relevant parts are included in the present invention as a reference; a reference to any document should not be construed as an admission that it is prior art with respect to the present invention. To the extent that any meaning or definition of a term in this document contradicts any meaning or definition of the same term in a document incorporated by reference, priority should be a value or definition given to this term in this document.

Although there have been illustrated and described specific ways embodiment of the present invention, qualified specialists will be obvious that various other changes and modifications can be made without disturbing the nature and volume and the gain. Therefore, it is implied that the attached claims cover all such changes and modifications are included in the scope of the present invention.

1. Composition containing:
(a) a lipase; and
(b) a bleaching catalyst, able to accept the oxygen atom from peroxyacids and transfer the oxygen atom oxidizable substrate, with the above-mentioned catalyst whitening includes iminium functional group and
this lipase is a polypeptide having an amino acid sequence that:
(a) has at least 90% identity with the wild-type lipase isolated from a strain of Humicola lanuginosa DSM 4109;
(b) compared with the indicated wild-type lipase comprises a substitution of an electrically neutral or negatively charged amino acids on the surface of the three-dimensional structure at a distance of not more than 15Å from E1 or Q249 on positively charged amino acid; and/or
(c) includes extension peptide at the C-end; and/or
(d) includes extension peptide at the N-end; and/or
(e) meets the following limitations:
(i) comprises a negatively charged amino acid in position e the indicated wild-type lipase;
(ii) comprises a negatively charged amino acid in the region corresponding to positions 90-101 of the indicated wild-type lipase; and
(iii) include neutral or negatively dawn the military amino acid in position, corresponding to N94 of the indicated wild-type lipase and/or has a negative or neutral total electric charge in the region corresponding to positions 90-101 of the indicated wild-type lipase.

2. The composition according to claim 1, characterized in that the catalyst whitening includes oxaziridine and/or dioxiranes functional group and/or capable of forming oxaziridine and/or dioxiranes functional group when akceptowania oxygen atom.

3. The composition according to claim 1, characterized in that the bleaching catalyst has a chemical structure corresponding to the chemical formula:

in which n and m independently have values from 0 to 4; each R1independently selected from substituted or unsubstituted radical selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, condensed aryl, heterocyclic ring group, a condensed heterocyclic ring group, nitro, halogen, cyano, sulfonato, alkoxy, keto, carboxylic and carbalkoxy radicals, and any two vicinal Deputy R1can be combined with the formation of condensed aryl condensed carbocyclic or condensed heterocyclic ring; each R2independently selected from substituted or unsubstituted RA is hiccuping, independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkaryl, aryl, aralkyl, alkylenes, heterocyclic ring group, alkoxy, arylcarboxylic groups, carboxialkilnuyu groups and amide groups; any R2can be connected with any other R2with the formation of a common ring; any genialny R2can be combined with the formation of carbonyl; and where any two R2can be combined with the formation of the substituted or unsubstituted condensed unsaturated fragment; R3represents C1-C20substituted or unsubstituted alkyl; R4denotes hydrogen or a fragment of Qt-A, where Q denotes a branched or unbranched alkylene, t=0 or 1, and a denotes an anionic group selected from the group consisting of OSO3-, SO2-, CO2-, OCO2-, ORO32-, ORO3N-and ORO2-; R5denotes hydrogen or fragment-CR11R12-Y-Gb-Yc-[(CR9R10)y-O]k-R8where each Y is independently selected from the group consisting of O, S, N-H or N-R8; and each R8independently selected from the group consisting of alkyl, aryl and heteroaryl, where these fragments are substituted or unsubstituted, and not avisio from whether they are substituted or unsubstituted, these fragments contain less than 21 carbons; each G is independently selected from the group consisting of CO, SO2SO, RHO and RHO2-, R9and R10independently selected from the group consisting of hydrogen and C1-C4-alkyl; R11and R12independently selected from the group consisting of hydrogen and alkyl, or, taken together, can be connected with the formation of a carbonyl; b=0 or 1; C can = 0 or 1, but must be = 0 if b = 0; y denotes an integer from 1 to 6; k denotes an integer from 0 to 20; R6denotes H or alkyl, aryl or heteroaryl fragment; where these fragments are substituted or unsubstituted; and X, if present, indicates suitable for balancing the charge of the counterion.

4. The composition according to claim 1, characterized in that the bleaching catalyst has a chemical structure corresponding to the chemical formula:

where R13denotes a branched alkyl group containing from 3 to 24 carbons or linear alkyl group containing from 1 to 24 carbon atoms.

5. The composition according to claim 1, characterized in that the bleaching catalyst has a chemical structure corresponding to the chemical formula:

where R13selected from g is PI, consisting of 2-butyloctyl, 2-pentylene, 2-hexyldecyl, isotridecyl and isopentenyl.

6. The composition according to claim 1, wherein the lipase is a variant of Humicola lanuginos lipase mutations T231R and N233R.

7. The composition according to claim 1, characterized in that it contains less than 5% by weight of the composition of the source of peroxide oxygen.

8. The composition according to claim 1, characterized in that it contains from 5 to 10% by weight of the composition, the source of the carbonate anion.

9. The composition according to claim 1, characterized in that it contains an inhibitor of migration of the dye.

10. The composition according to claim 1, characterized in that it contains:
(a) less than 5% by weight of the zeolite composition of the main component;
(b) optionally, less than 5% by weight of the phosphate composition of the main component; and
(c) optionally, less than 5% by weight of the composition, of silicate salt.

11. The composition according to claim 1, characterized in that it contains diacyl - and/or tetrachlorosilane materials.

12. The composition according to claim 1, characterized in that it contains oxybenzenesulfonate the bleach activator and a source of peroxide oxygen.

13. The composition according to claim 1, characterized in that it contains pre-prepared peroxynitrate.



 

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18 cl, 4 dwg, 14 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention pertains to compositions of granulated synthetic detergents, meant for manual and machine washing (in any type of machine) and soaking all types of textiles, including coloured and other household needs. The detergent contains the following components in the given % mass: anionic surface active agent sodium alkylbenzenesulfonate 9-12; non-ionic surfactant 2-5; sodium tripolyphosphate 15-30; dispergator 0.3-1.2; carboxymethyl cellulose 0.3-0.7; sodium silicate 3-6; modified polyalkylene glycol 0.2-0.6; enzyme 0.3-0.8; sodium carbonate 6-12; photo-bleaching agent 0.003-0.020; optical brightener 0.05-0.20; fragrance component 0.1-0.3; sodium sulphate and water up to 100. The non-ionic surfactant preferably contains oxyethylated monoalkylphenols based on propylene trimers or oxyethylated fatty alcohols. The dispergator used is sodium polyacrylate or sodium salt of a copolymer of maleic or acrylic acid or a sodium salt of a copolymer of acrylic, methacrylic and maleic acid. Alternatives of the synthetic detergent are also described.

EFFECT: increased effectiveness of the detergent, bleaching effect after washing, wider assortment of high quality granulated synthetic detergents.

7 cl, 1 tbl

FIELD: chemistry.

SUBSTANCE: invention is meant for soaking, washing and bleaching all types of textile articles, except articles from natural silk and wool, in any kind of machine, and also hand wash. Substance contains in % mass: an anionic surfactant 7-15, nonionic surfactant oxyethylated fatty alcohol 2-5, sodium tripolyphosphate 15-25, sodium ethylene-diaminotetraacetate (versene) 0.3-1, polycarboxylate, containing monomers of acrylic acid 0.2-0.6, carboxymethyl cellulose (CMC) (in terms of 100% of the share of the main substance) 0.4-0.6, sodium silicate (in terms of SiO2) - 2-5, sodium perborate or sodium percarbonate (in terms of activated oxygen) 1.5-4, tetraacetylethylenediamine (TAED) 0.5-3, enzymes 0.4-1, caustic ash 5-15, mixture of sodium carbonate and amorphous sodium silicate 2-5, optical brightener 0.05-0.4, perfume 0.1-0.3, sodium sulphate and water till 100.

EFFECT: increase in the effectiveness of the detergent with a whitening effect, removal of all kinds of dirt while adding extra softness without an irritating effect on the skin during hand washing, reducing the temperature regimes of washing, reduction in the harmful effect to the metallic part of the washing machine.

9 cl, 2 tbl

FIELD: chemistry.

SUBSTANCE: detergent contains the components as follows, wt %: anionic surface active agent (SAG) - alkylbenzol sodium sulphonate 10-16; nonionic SAG - oxyethylated fatty alcohols or oxyethylated alkylphenol 2-5; sodium tripolyphosphate 15-25; organophosphonate compound - sodium salt 1-hydroxyethylidene of phosphonic acid or sodium diethylentriaminopentaxys-(methylene phosphonate) 0.2-0.6; polycarboxylate 0.5-1.5; carboxymethyl cellulose 0.3-0.6; modified polyalkylene glycol 0.2-0.6; optical bleaching agent 0.05-0.3; soda ash 3-6; liquid glass 3.5-6.0; enzyme 0.4-0.7; defoaming agent 0.05-1.5; aromatiser 0.15-0.3; sodium sulphate and water to 100.

EFFECT: higher efficiency of bleaching detergent, all type decontamination with additional softening of fabric and without irritation of hand skin during manual washing, lower temperature modes of washing, reduced damage effect on metal parts of washing machines.

10 cl, 2 tbl, 5 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to compositions which contain certain versions of lipase and a toned agent for fabric, and includes use of such compositions for cleaning and/or treating surface areas or fabric.

EFFECT: improved deposition of temporary colourant, reduced activity of the enzyme which leads to bad smell, and improved perception of cleanness.

17 cl, 3 tbl, 16 ex

FIELD: chemistry.

SUBSTANCE: compositions contain certain versions of lipase and a photo-bleaching agent based on xanthene dye, a photoinitiator and their mixtures.

EFFECT: more efficient cleaning, leading to minimal undesirable bad smells.

11 cl, 3 tbl, 16 ex

FIELD: chemistry.

SUBSTANCE: detergent composition contains a polymer combined with a surfactant or an inorganic detergent component and auxiliary ingredients. The fat purification efficiency index of the detergent composition is at least equal to 10. The polymer is a random grafted copolymer which has a hydrophilic skeleton and hydrophobic side chains, obtained by grafting (a) polyethylene oxide; (b) vinyl ester of acetic and/or propionic acid; and/or C1-4alkyl ester of acrylic or methacrylic acid; and (c) modifying monomers. The detergent compositions preferably additionally contain lipase enzyme.

EFFECT: improved removal of fat contaminants and stains with reduced amounts of conventional surfactants or inorganic detergent components.

22 cl, 6 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to a composition which contains lipase, and a bleaching catalyst which can accept an oxygen atom from a peroxy acid and transfer the oxygen atom to an oxidisable substrate.

EFFECT: less bad smell which arises when using lipase enzymes in detergents.

13 cl, 4 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: cleaning compositions contain organic catalysts having improved enzyme compatibility and having the following formulae: where each R1 independently denotes a branched alkyl group selected from a group comprising 2-butyloctyl, 2-pentylnonyl, 2-hexyldecyl, isodecyl, isotridecyl and isopentadecyl, or a linear alkyl group containing 11-18 carbon atoms. The composition also contains one or more auxiliary ingredients.

EFFECT: cleaning compositions with efficient bleaching at low water temperature.

15 cl, 16 ex

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