Composition for treating multiple sclerosis (versions)
SUBSTANCE: invention refers to psychoneurology, particularly to an agent for treating multiple sclerosis. A composition (solid or liquid dosage form) contains triiodide 1,3-diethylbenzimidazolium as an agent, low-molecular surgical polyvinylpyrrolidone, presented as a solubiliser, and an agent stabiliser, and in addition in the liquid dosage form - ethanol as a solvent.
EFFECT: composition under the invention exhibits high therapeutic effectiveness in treating multiple sclerosis, and is characterised by relieving undesirable by-effects.
2 cl, 4 ex
The invention relates to the field of Psychoneurology, in particular to the means for the treatment of multiple sclerosis.
Well-known medication for the treatment of multiple sclerosis: Betaferon recombinant human interferon beta-1b (Mashkovsky PPM Medicines. M: New Wave, 2003, s-325). Currently Betaferon - only drug, the effectiveness of which is shown in long-term (5 years), placebo-controlled study (totolan N.A. Betaferon in the treatment of multiple sclerosis: the standard of proof efficiency // Journal of neurology and psychiatry. No. 7, 2005, s-71).
The disadvantage of this drug is the relatively low efficiency of its use - reduce the frequency of exacerbations of the disease and its severity only 30%, the presence of such side effects as increased depressive symptoms (V.S. Sokolov, totolan N.A., V.M. Klimenko Emotional changes during treatment with Betaferon patients with multiple sclerosis // "Stress and behavior" VII Multidisciplinary conference of biological psychiatry, Novosibirsk, 2003), as well as very high cost of pharmacotherapy with the use of Betaferon.
Also recently in the treatment of multiple sclerosis is very successfully used the drug Copaxone - glatiramer acetate (Zavalishin I.A., Schwartz GY Copaxone in the treatment of multiple sclerosis is (collection of articles). M: Miklos, 2007, pp.5-8). However, the clear disadvantage is the high cost of pharmacotherapy with the use of Copaxone.
The closest to the essential features of the composition of the same purpose is the technical solution according to the patent No. 2007112501 "Benzimidazole derivatives, compositions containing them, their preparation and use", by which the connection specified in the patent formula, their pharmaceutically acceptable salt, diastereomers, enantiomers or mixtures thereof are used in the manufacture of medicinal products for the treatment of multiple sclerosis. However, the connection of the specified General formula are not derived from the cation benzimidazole, which eliminates the possibility of formation of pharmacologically highly complex compounds with imidazole ring of these compounds.
The invention, which defines its purpose is to create new drugs with pronounced pharmacological activity for the treatment of multiple sclerosis with high therapeutic efficacy, reducing unwanted side effects, lower cost of treatment.
The technical result that can be achieved with the implementation of the invention is to provide a composition with high pharmacological activity for the treatment of multiple sclerosis C is through the use of its complex connections active iodine and Detelinara derived cation benzimidazole, namely triiodide 1,3-diethylbenzamide as the active agent.
The technical result is also achieved in that the composition for the treatment of multiple sclerosis (solid or liquid form) contains high pharmacological activity triode 1,3-diethylbenzamide as active principle, a low-molecular polyvinylpyrrolidone medical, which solubilizer and stabilizer for the active agent, and optionally in liquid form - solvent (ethyl alcohol), in the following ratio, wt.%:
|The low-molecular polyvinylpyrrolidone|
|Ethyl alcohol, 95%||60,0-92,5|
for solid form.
|The low-molecular polyvinylpyrrolidone|
|medical||of 75.0 to 90.0|
Justification of the selected limits of the concentrations of the components of the composition is the following. When the concentration of the active principle - triiodide 1,3-diethylbenzamide below 1.5% wt.% reduced therapeutic activity of the composition. When the concentration of the 1,3-diethylbenzamide of triiodide above to 25.0 wt.% occurs the probability of irreversible loss of solubility of the active principle, which also leads to reduced therapeutic activity of the composition. The concentration of polyvinylpyrrolidone below 6.0 wt.% does not provide the necessary solubility of triiodide 1,3-diethylbenzamide. Concentration of the solvent (ethyl alcohol) and its ratio in the composition depends on the need in each case the consistency of the composition (solid dosage form, the solution). In the case of production of the composition in the form of solid dosage forms such as the need to use solvents is absent, but the presence of polyvinylpyrrolidone is necessary to ensure the solubility of the active agent in the gastrointestinal tract. The excess solvent concentrations above 92,5,0 wt.% leads to decrease in the content of the composition mass fraction of active start - triiodide 1,3-diethylbenzamide, and consequently, reduce therapeutic activity of the composition.
A method of obtaining a composition for the treatment of disseminated is lerosa can be realized with the implementation of the specified destination as follows. As an active principle obtained compositions used triode 1,3-diethylbenzamide (Pharmacopeia 42-0609-6576-05), which causes its qualitative and quantitative composition. In the manufacture of liquid composition with ethanol 95% (Pharmacopeia 42-3072-00) dissolve the white powder of low molecular weight polyvinylpyrrolidone medical (Pharmacopeia 42-03-84-2668-02), used as a solubilizer and stabilizer of the active principle, in 95%ethyl alcohol. Then the resulting solution dissolve finely ground crystals dark brown triiodide 1,3-diethylbenzamide.
In the manufacture of solid dosage forms of the compositions of finely divided crystals of triiodide 1,3-diethylbenzamide mechanically mixed with white powder polyvinylpyrrolidone medical low molecular weight. The resulting mixture produce solid dosage forms (tablets, capsules).
A method of obtaining a composition for the treatment of multiple sclerosis is safe for individuals involved in the process.
The possibility of carrying out the invention is confirmed by the following:
The low-molecular polyvinylpyrrolidone medical (Mm 12600 D) in an amount of 16.0 wt.% dissolved at 55±5°C in ethyl alcohol, taken inthe number 80,0 wt.%. The resulting solution dissolve the crystals of 1,3-diethylbenzamide of triiodide in the amount of 4.0 wt.%. Get composition (solution for oral administration) for the treatment of multiple sclerosis.
The low-molecular polyvinylpyrrolidone medical (Mm 12600 D) in an amount of 6.0 wt.% dissolved at 55±5°C in ethyl alcohol, taken in an amount 92,0 wt.%. The resulting solution dissolve the crystals of 1,3-diethylbenzamide of triiodide in the amount of 2.0 wt.%. Get composition (solution for oral administration) for multiple sclerosis.
The low-molecular polyvinylpyrrolidone medical (Mm 12600 D) in an amount of 75.0 wt.% mechanically mixed with finely ground crystals of 1,3-diethylbenzamide of triiodide in the amount of 25.0 wt.%. Metered dose resulting mixture is Packed in gelatin capsules. Get a solid dosage form is a capsule for oral administration for treatment of multiple sclerosis.
The low-molecular polyvinylpyrrolidone medical (Mm 12600 D) in an amount of 90.0 wt.% mechanically mixed with finely ground crystals of 1,3-diethylbenzamide of triiodide in the amount of 10.0 wt.%. Metered dose resulting mixture is subjected to extrusion. Get a solid dosage form tablets for oral administration for treatment of multiple sclerosis.
The wedge is ical confirmed the efficiency of use of the claimed composition for the treatment of patients with multiple sclerosis. Described in the examples options composition was applied surveyed patients twice a day orally in number, containing the dose corresponding to 40 mg of the active principle.
Patient B., born in 1979
The signs of the disease since September 2003: weakness in legs, loss of sight in his right eye.
Neurological status: Krupnorazmernyj horizontal nystagmus, high knee reflexes, bilateral symptom Babinski. Reflexes along the pyramidal type, instability in the Romberg position.
MRI from 20.11.2003, Conclusion: MRI signs of multiple foci of demyelination, the acute phase, atrophic changes of the cerebral cortex.
Since 2003 pharmacotherapy composition obtained in example 1. 1.5 months condition began to improve after 3 months showed a significant improvement.
MRI from 13.01.2005, Conclusion: MRI signs of demyelinating diseases of the brain.
MRI from 23.07.2006, Conclusion: MRI signs of multiple sclerosis with elements of atrophy of the cerebral cortex. Compared with MRI from 13.01. 2005 in a stable condition.
Patient K., born in 1981
The signs of the disease since September 2003: weakness, numbness in the right limbs, double vision when looking to the side.
Neurological status: Horizontal and vertical nystagmus, paresis VI and VII FMN, dynamic and static taxi is, tendon reflexes are high, the uncertainty in the Romberg position, bilateral symptom Babinski.
Were treated at the clinic at the Department of neurology, the Rostov state medical University with 17.02.06 on 27.02.06. Clinical diagnosis: multiple sclerosis, spinal form, acute stage, approaches pyramidal syndrome. Treatment: contrical, gemodez, piracetam, vitamins a, E, B6, solumedrol, carbamazepine.
At discharge: disabled.
MRI from 10.09.2004, Conclusion: MRI signs of demyelinating lesions of the brain.
MRI from 27.02.2006, Conclusion: MRI signs of demyelinating disease. Identified new stem and hemispheric lesions.
The composition obtained according to example 2 uses from March 2006 3 months marked reduction of symptoms was ready to get to work.
Patient K., born in 1971
The signs of the disease may 2002: dizziness and reduced vision. The recent escalation in the summer of 2005, when there was a numbness of the right hand, blurred vision.
Was hospitalized in the clinic of nervous diseases and neurosurgery Rostov state medical University in 28.11.2005, 08.12.2005, and in the neurological Department of the hospital No. 1, Rostov-on-don with 20.02.2007, 28.02.2007, and 26.12.2007, 10.01.2008 was diagnosed with multiple sclerosis, recurring-remitting course, the stage of exacerbation, pronounced MoH is eccolo-pyramidal syndrome, dysfunction of the pelvic organs, stenocardiceskie syndrome. Treatment: traditional, gets Copaxone since March 2006.
MRI from 24.11.2005, Conclusion: MRI signs of multiple sclerosis.
Started therapy composition obtained in example 3, against the backdrop of worsening during treatment with Copaxone since March 2008, After 2-3 months showed a significant improvement. Was ready to get to work. Aggravation against the background of pharmacotherapy composition is missing.
Patient S., born in 1957
Was on treatment in 2002, 2003 and 2005 in the neurological Department of the railway hospital and hospital № 6, Rostov-on-don diagnosed with multiple sclerosis, spinal shape, having a progressive course, tetraparesis in a stage of dynamic deterioration. Group II disability.
MRI from 14.05.2002 Conclusion: Signs of demyelinating lesions of the brain.
MRI from 13.05.2005, Conclusion: MRI signs of demyelinating disease. The number of lesions stable, progressive atrophic changes.
Therapy composition obtained in example 4, is held from 2005 For the observation time from the start of treatment composition stable neurological status, exacerbations are not checked.
Patient W., born in 1981
The signs of the disease since September 2005: severe headaches, sudden decreased vision in his right eye from 1.0 to 0.1.<> Neurological status: adynamic-cephalgic syndrome. GNI - emotionally labile, estensione, disturbing. FMN is reduced vision in the right. 2-sided nystagmus, in the Romberg shakiness, coordinatorsee sample performs insecure with intention and promahivayas.
Was treated in the neurological Department of the hospital No. 6, Rostov-on-don 13.07.2006, 04.08.2006, treatment: Parenteral pentoxifylline, Mexidol, Riboxin, Actovegin, piracetam, Mildronate. Interline - atarax, Berlition, FT. Neurological status at discharge does not differ from that in the receipt.
Brain MRI from 20.10.2005, Conclusion: MRI signs of multifocal lesions of the white matter of the brain.
Brain MRI from 28.03.2006, Conclusion: there has been regression of the lesion in the right leg of the brain and the appearance of the lesion in the shaft of the corpus callosum.
In September 2006 initiated pharmacotherapy composition obtained in example 1. After 3 months marked reduction of symptoms, recovered sight in his right eye.
MRI from 31.05.2007,: reduction of process compared to MRI from 28.03.2006,
MRI from 15.05.2008,: signs of multiple sclerosis, the reduction process.
Currently, no complaints, functional.
The composition of the claimed composition can be obtained technological way. The composition is stated with the tava can be used as a drug for the treatment of multiple sclerosis in medicine.
1. Composition for treating multiple sclerosis, comprising triode 1,3-diethylbenzamide as active principle, a low-molecular polyvinylpyrrolidone health as a solubilizer and stabilizer for the active agent, and the solvent ethyl alcohol 95% in the following ratio, wt.%:
|The low-molecular polyvinylpyrrolidone|
|Ethyl alcohol, 95%||60,0-92,5|
2. Composition for treating multiple sclerosis, comprising triode 1,3-diethylbenzamide as the active agent and a low molecular weight polyvinylpyrrolidone health as a solubilizer and stabilizer of the active principle in the following ratio, wt.%:
|The low-molecular polyvinylpyrrolidone|
|medical||of 75.0 to 90.0|
SUBSTANCE: present invention relates to novel substituted 2-alkylsulfanyl-3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines of general formula 1, their pharmaceutically acceptable salts and/or hydrates having serotonin 5-HT6 receptor antagonist properties. In general formula 1 , R1 and R3 independently denote optionally identical C1-C3 alkyl, and R2 is a -(CH2)nX group or R1 and R3 independently denote different substitutes selected from C1-C3 alkyl or a -(CH2)nX group, and R2 is a hydrogen atom or C1-C3 alkyl; R4 is C1-C3 alkyl; Ri 5 is a hydrogen atom, one or two identical or different halogen atoms, C1-C3 alkyl; equals 0, 1 or 2; n equals 0, 1, 2 or 3; X is a carboxyl CO2H, C1-C3 alkyloxycarbonyl, aminocarbonyl CONR6R7 or amino group NR6R7; except compounds in which R3 is a -(CH2)nX group, where X is an amino group NR6R7 and n equals 0; R6 and R7 are optionally identical and denote a hydrogen atom, optionally substituted C1-C5 alkyl or R6 and R7 together with the nitrogen atom with which they are bonded form an optionally substituted 6-member azaheterocyclyl containing 1-2 nitrogen atoms in the ring, where the substitute is selected from C1-C3 alkyl.
EFFECT: obtaining compounds which can be used in treating diseases of the central nervous system during prevention or treatment of cognitive disorders, neurodegenerative diseases, psychiatric disorders, have anxiolytic and nootropic effect and can be used to prevent and treat anxiety disorders and enhance mental capacity.
25 cl, 2 tbl, 12 ex
SUBSTANCE: present invention relates to novel substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines of general formula 1, their pharmaceutically acceptable salts and/or hydrates having serotonin 5-HT6 receptor antagonist properties. The compounds can be used in treating and preventing various diseases of the central nervous system, pathogenesis of which is associated with 5-HT6 receptors, particularly cognitive disorders, neurodegenerative diseases and psychiatric disorders. The compounds have anxiolytic and nootropic effect and can also be used for preventing and treating anxiety disorder and for enhancing metal capacity. In formula 1 , R1 is a hydrogen atom, C1-C3 alkyl, (C1-C3)alkyloxy(C1-C3)alkyl, hydroxy(C1-C3)alkyl, pyridyl; R2 is a hydrogen atom, halogen atom, C1-C3 alkyl, phenyloxy or pyridyloxy; R3 is a hydrogen atom, C1-C3 alkyl, C1-C3 alkyloxy, (C1-C3)alkyloxy(C1-C3)alkyl, hydroxy(C1-C3)alkyl, pyridyl; R4 is C1-C3 alkyl; R5 is a hydrogen atom, one or two halogen atoms, C1-C3 alkyl, C1-C3 alkyloxy or hydroxyl; X is a sulphur atom or thionyl group (SO).
EFFECT: obtaining compounds which can be used in treating and preventing various diseases of the central nervous system.
24 cl, 9 dwg, 4 tbl, 19 ex
SUBSTANCE: present invention relates to novel 2-alkylamino-3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines of general formula 1, their pharmaceutically acceptable salts and/or hydrates having serotonin 5-HT6 receptor antagonist properties. The compounds can be used to treat and prevent development of various diseases of the central nervous system, pathogenesis of which is associated with 5-HT6 receptors, particularly Alzheimer's disease, Parkinson's disease, Huntington disease, schizophrenia, other neurodegenerative diseases and cognitive disorders. In general formula 1 , R1 is a hydrogen atom, C1-C3alkyl, C1-C3alkyloxyC1-C3alkyl, hydroxyC1-C3alkyl, adamantyl, optionally substituted phenyl, 5-6-member heterocyclyl containing a nitrogen or oxygen heteroatom, possibly condensed with a benzene ring; R2 is a hydrogen atom, halogen atom, C1-C3alkyl, pyridyloxy; R3 is a hydrogen atom; C1-C3alkyl; optionally substituted amino group selected from amino, mono- or di(C1-C3alkyl)amino, di(C1-C3alkyl)aminoC2-C3alkylamino, N-[di(C1-C3alkyl)aminoC2-C3alkyl]-N-(C1-C3alkyl)-amino; C1-C3alkyloxy, C1-C3alkyloxyC1-C3alkyl, hydroxyC1-C3alkyl; 6-member azaheterocyclyl, possibly containing an extra nitrogen or oxygen atom, a -N(C1-C3alkyl) group; R4 is C1-C3alkyl; R5 is a hydrogen atom, one or two halogen atoms or C1-C3alkyl.
EFFECT: design of a method of obtaining compounds, a pharmaceutical composition and a medicinal agent for treating and preventing various diseases of the central nervous system.
25 cl, 12 dwg, 3 tbl, 20 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine and aims at treating the conditions associated with amnesia and impaired cognition. A medically indigent patient is prescribed with the effective amount of a composition containing a mixed extract prepared of Scutellaria plants with high concentration of free V-ring flavonoids, including Baicalin, and an extract of Acacia plants with high concentration of flavanes, including catechine and epicatechin.
EFFECT: methods ensure restoration and preservation of cognition and memory.
44 cl, 15 ex, 2 tbl, 17 dwg
SUBSTANCE: invention refers to novel compounds of the general formula (I) , where R1, R2 are independently H or C1-C6-alkyl; R3, R4 are independently H or C1-C6-alkyl; R5 is halogen, CN; n, m or o are 0, 1 or 2; and to pharmaceutically acceptable salts thereof.
EFFECT: compounds with monoaminooxidase B inhibition properties applicable in obtainment of pharmaceutical drugs with relevant effect.
14 cl, 3 dwg, 31 ex
SUBSTANCE: present invention relates to serotonin 5-HT6 receptor antagonists - new substituted 3-sulphonyl-6,7,8,9-tetrahydro-pyrazolo[1,5-a]pyrido[4,3-e]pyrimidines of formula and substituted 3-sulphonyl-5,6,7,8-tetrahydro-pyrazolo[1,5-a]pyrido[4,3-c1]pyrimidines of general formula 2, a medicinal base and pharmaceutical compositions containing the medicinal base in form of the said compounds, as well as to a method of treating and preventing development of different conditions and diseases of the central nervous system of humans and warm-blooded animals. In formulae and Ar is phenyl which is optionally substituted with halogen atoms, or a 6-member heteroaryl which contains a nitrogen atom in the ring; R1 is a hydrogen atom, C1-C3alkyl, hydroxy C1-C3alkyloxy group, C1-C3alkylsulphanyl group; R2 is a hydrogen atom or C1-C3alkyl, R3 is a hydrogen atom optionally substituted C1-C3alkyl or tert-butyloxycarbonyl.
EFFECT: obtaining compounds for preventing development of different conditions and diseases of the central nervous system of humans and warm-blooded animals.
16 cl, 3 tbl, 1 dwg, 10 ex
SUBSTANCE: invention relates to field of medicine and pharmaceutical industry and represents pharmaceutical combination for treatment of cerebral circulatory insufficiency and psychodependent form of erectile dysfunction, including choline alfoscetate in amount 50-600 mg per one intake and hopantenic acid or its pharmaceutically acceptable salt in amount 20-800 mg per one intake.
EFFECT: invention ensures reduction of frequency, duration and intensity of headache, dizziness, fatigability, irritability, improvement of memory for current events and sleep, as well as increase of erectile dysfunction (ED), reduction and fixation of stable positive motivation for quality erection and full orgasm in case of psychodependent form of ED; simultaneously, due to manifestation of synergic effect, which results from the use of claimed combination, it became possible to reduce day dose of hopantenic acid or its salt from 1,5 mg to 0,5 mg.
12 cl, 4 ex, 24 tbl, 4 dwg
SUBSTANCE: methods according to the invention consist in introducing an Aβ 16-23 fragment having an amino acid sequence KLVFFAED of 16-23 residues SEQ ID NO:1. Besides the invention concerns the Aβ 16-23 fragment and a pharmaceutical composition containing it.
EFFECT: feasible prevention and treatment of Alzheimer's disease ensured by inhibition of amyloid deposition in cerebrum.
72 cl, 2 dwg, 1 ex
SUBSTANCE: invention refers to medicine, namely to neurology, and can be used in treating the patients with multiple sclerosis. That is ensured by infusion of rituximab in a dose 1 g followed by introduction of mitoxantrone in a dose 20 mg and another infusion of rituximab in a dose 1 g 13-15 days later. A common preanaesthetic medication precedes infusion of rituximab.
EFFECT: method ensures fast therapeutic effect and prolonged remission in all forms of multiple sclerosis without a concomitant therapy, including chemotherapy.
1 ex, 11 dwg
SUBSTANCE: present invention relates to new compounds of formulae and , in which radicals and symbols assume values defined in the formula of invention, e.g. to 1H-indazoles, 1,2-benzisoxazoles and 1,2-benzisothiazoles. Said compounds are receptor ligands of the α-7 nAChR subtype. The invention also relates to a pharmaceutical composition containing the said compounds.
EFFECT: possibility of using the said compounds to make medicinal agents for treating diseases associated with impaired functioning of nicotinic acetylcholine receptors and their abnormal functioning, primarily in brain cells.
46 cl, 85 ex
SUBSTANCE: invention refers to a soft capsule containing a compound, causing irritation in oral cavity, particularly, (2R)-2-propyloctane acid or its salt. Said compounds are suitable as an agent to prevent, treat and/or delay of progression of symptoms of various neurodegenerative diseases. The capsule exhibits durability 150 to 400 H when crack-tested, decay time 3 to 10 minutes when disintegration tested.
EFFECT: soft capsule under the invention is chewing-resistant, it can be ingested safely without sensation of burning, hotness, pain in oral cavity; the capsule ensures long storage without solubility delay.
34 cl, 24 tbl, 8 ex
SUBSTANCE: invention concerns chemical-pharmaceutical industry, more specifically to a pharmaceutical composition expressing nootropic activity and cholinomimetic action. There is offered original pharmaceutical composition containing choline alphoscerate as an active ingredient in therapeutically effective amount and pharmaceutically acceptable carriers, differing that as pharmaceutically acceptable carriers it contains macrogol (polyethylene glycol 400) and povidone (Plasdone or collidone). There is also offered method for making thereof that enables making a high-yield end product. The pharmaceutical composition produced by the declared method exhibits minimum by-effects, improved bioavailability and prolonged storage stability.
EFFECT: invention can be used for treatment or prevention of CNS diseases and consequences of craniocereberal injuries.
11 cl, 1 tbl
SUBSTANCE: invention concerns medications, particularly self-emulsifying system of butylphthalide drug delivery, including 1% to 65% of butylphthalide, 10% to 65% of emulsifying agent, and filler. Emulsifying agent is a mix of polyoxyetylene castor oil and polyethyleneglycol-8-glycerin caprilate/caprate, where polyoxyethylene castor oil to polyethyleneglycol-8-glycerin caprilate/caprate ratio is 1:0.5 to 1:1.5. Invention also concerns medication containing claimed delivery system, and method of system obtainment.
EFFECT: faster achievement of maximum butylphthalide concentration, increased maximum concentration, improved butylphthalide stability.
9 cl, 1 dwg, 3 tbl, 18 ex
SUBSTANCE: invention refers to pharmaceutical set of cancerous disease treatment and prevention. The composition comprises cisdiammoniumdichlor-trans-dihydroxoplatinum (IV), in particular its salts, physically separated from the carrier selected from the group comprising tablet, capsule, coated pill, suppository, ointment, cream, solution for injection where the carrier is combined with cisdiammonium-dichlor-trans-dihydroxoplatinum (IV) immediately prior to use. The invention also refers to pharmaceutical composition obtained from the claimed set.
EFFECT: physical separation of active agent and carrier and their integration immediately before use enables to significantly increase antineoplastic activity of composition.
11 cl, 4 tbl
SUBSTANCE: invention is applied for treatment of purulent wounds and burns, pyoinflammatory dermatopathies, and for acceleration of healing and improvement of wound healing conditions. The composition possesses antibacterial and necrolytic action; it contains an active complex of bacteriolytic and proteolytic enzymes - Lisoamidase, and a base for soft formulation of the composition. The base contains a thermally stable perfluororganic compound emulsion with gas-transport properties and mixed hydrophilic substances specified as follows: proxanol-268, polyethylene oxides, propylene glycol, dimexide, hyaluronic acid or sodium hyaluronate, sorbite, glycerine, aerosil. Besides, the composition can contain at least one desired additive chosen from: anaesthetic (Chinoxycaine, Trimecaine, Pyromecaine, Lidocaine or mixed), a reparative process stimulator (methyluracil, acetamine, ethadene, calcium pantothenate, Solcoseryl or mixed) or mixed. The composition is made in the form of ointment or gel, rectal suppositories or capsules.
EFFECT: extended application, enhanced therapeutic activity and ease of use; lower consumption of the active substance; ensured anaesthetising effect; improved microcirculation in wound tissues, managed inflammatory processes, additional stimulation of reparative processes.
6 cl, 2 tbl, 19 ex
SUBSTANCE: invention concerns pharmaceutical technology and medicine and concerns a compound for capsules. The compound includes the β form of 2,4 dioxo-6-methyl-1,2,3,4-tetrahydropyrimidin as active substance. It also contains talc, calcium stearate and sucrose at a certain parity of components.
EFFECT: peroral intake of an agent; absence of irritating action on mucous coat of stomach.
SUBSTANCE: invention concerns pharmaceutical technology and medicine and concerns a compound for capsules. An antimicrobial and interferon inducing agent includes a γ-modification of aminobenzenesulphamide as active substance. It also contains talc, calcium stearate and sucrose at a certain parity of components.
EFFECT: invention provides maximum therapeutic concentration of the preparation in blood.
SUBSTANCE: medicinal preparation for diabetes treatment contains active pharmaceutical ingredients, obtained from root of rehmania (Radix Rehmanniae), root of astragalus (Radix Astragali), rhizomes of yam (Rhizoma Dioscoreae), root of kudzu hemp (Radix Puerariae Lobatae), root of snake gourd (Radix Trichosanthis), baculums with stigmas of corn (Stylus Zeae Maydis), fruits of schizandra (Fructus Schisandrae Sphenantherae) and Glibenclamidum (Glibenclamide), taken in a certain parity. Way of preparation of a medicinal preparation in the form of drop-pills. A way of preparation of a medicinal preparation in the form of pills. A way of preparation of a medicinal preparation in the form of capsules. A way of preparation of a medicinal preparation in the form of tablets. A way of preparation of a medicinal preparation in the form of granules. A way of preparation of a medicinal preparation in the form of soft capsules. A way of preparation of a medicinal preparation in the form of a powder.
EFFECT: efficiency for diabetes treatment.
14 cl, 3 tbl, 18 ex
SUBSTANCE: invention concerns a dispersion of crystals or granules of active substance in lipophilic filler where crystals or granules are covered for taste masking. The invention also concerns chewing or quickly dissolved soft gelatinous capsules filled with the specified dispersion, and also a way of manufacture of such forms. Use of considerable quantities of active substance which should be accepted at unitary introduction, and maintenance of satisfactory release of active substance in vivo is possible.
EFFECT: new dosed out forms are stable throughout all period of storage.
15 cl, 17 tbl, 5 ex
SUBSTANCE: present invention concerns area of medical products, in particular, to the capsule of a medicinal preparation made in the form of an elastic, soluble in a human body, monolithic body with a cavity for placing of a liquid medicinal preparation, having an inflow with a notch on an outer side, with the through aperture executed in it; the capsule is fixed on clothes. Such performance of the capsule excludes leak of a liquid medicinal preparation at an abruption from it, it is convenient for the patient as allows receiving a medicinal preparation in time.
EFFECT: exclusion of leak of a liquid medicinal preparation at an abruption from it, it is convenient for the patient as allows receiving a medicinal preparation in time.
1 dwg, 1 tbl, 5 ex
FIELD: food industry.
SUBSTANCE: invention refers to chemico-pharmaceutical industry and food industry, and relates preparation for human or animal using. It includes 0.1-10 wt % composition, containing polyphenol with at least 90 wt % of epigallocatechin gallate (EGCG), (counting on dry substance of composition containing polyphenol), and 30-80 wt % of isomaltulose for disguise of unwanted taste components, especially bitter substances in preparations, especially in preparations containing tea extract.
EFFECT: invention provides high disguise of bitter taste level of polyphenol composition.
34 cl, 1 ex, 9 tbl