Method for short-term optimisation of thromboplastin formation activity in patients with arterial hypertension and impaired glucose tolerance

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to cardiology and endocrinology, and concerns optimisation of thromboplastin formation activity in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by the integrated treatment including graduated static and dynamic physical activity, daily swimming in a pool for at least 20 minutes, and introduction of metformin in dosage 500 mg 2 times a day and lisinopril in dosage 10 mg once a day in the morning for 1 month.

EFFECT: complex of specific medicines and physical activity combined with empirically prescribed length of treatment provides normalisation of thromboplastin formation that in turn reduces risk of thrombotic complications in the case patients.

1 ex

 

The invention relates to medicine, namely to cardiology and endocrinology.

The closest analogue of the proposed method to normalize thromboelastography in patients with arterial hypertension (AH) with impaired glucose tolerance (IGT) is a method of influence on thromboelastography in patients with metabolic syndrome through introduction of lovastatin within 1 month (Medvedev I.N. and other Correction of platelet aggregation hypertensive patients with metabolic syndrome using lovastatin // Russian journal of biomedical Medline.ru, 2003. - T4. - S-436).

The source could not even get close to normal levels thromboelastography in patients with metabolic syndrome.

The claimed method differs from the known fact that instead of lovastatin administered Metformin 500 mg 2 times a day, and lisinopril 10 mg 1 time a day, morning and appoint rationally dosed static and dynamic exercise and daily swimming in the pool at least 20 minutes a day.

In the literature there are recommendations for physical training and swimming for the correction of metabolism in the elements of the metabolic syndrome (Diamond, VA, Supportive AV, Shlyakhto E.V., Krasilnikova H. Metabolic cardiovascular syndrome. SPb.: Ed SPb. (MCM). 1999. - 208 S.).

In patients with IGT to reduce blood pressure often is prescribed lisinopril. For the correction of insulin resistance sick AG with IGT is assigned to Metformin. However, never before medical complex consisting of dosed physical activity, medications lisinopril and pioglitazone, have not been applied in patients with IGT to normalize increased their thromboelastography.

The aim of the invention is the normalization thromboelastography in patients with IGT.

The essence of the proposed method lies in the fact that for the normalization of thromboelastometry sick AG with IGT for 1 month assigned to dosed static and dynamic exercise, daily swimming in the pool at least 20 minutes a day, drugs Metformin at a dose of 500 mg 2 times a day morning and lisinopril 10 mg 1 time per day in the morning.

The method allows to normalize thromboelastography in patients with IGT within 1 month. Subject to the subsequent recommendations of the proposed method can be maintained at a normal level thromboelastometry that will significantly improve the quality of life of patients with arterial hypertension with IGT, to reduce their pathological burden, reduce the number of cases of temporary disability, to accelerate and improve the quality of inpatient treatment, the claim is ucit disability, and also to prolong the life and reduce mortality of patients with arterial hypertension with IGT from heart attack and stroke.

The inventive method is carried out as follows.

The formation of endogenous thromboplastin is determined by R. Biggs, Douglas A.S., Macparlane R.G. The formation of throm-boplastin in human blood.// J. Physiol. 1953. - vol.119, No. 1. - p.89-104.

The principle of the method. Activity and the formation of thromboplastin from the component plates, deproclamation plasma and serum analyzed blood thrombin time test plasma in one-minute intervals. During the incubation of this mixture with calcium within 3-6 min is formed of highly active thromboplastin.

To determine endogenous thromboplastin need the following ingredients:

1. suspension of platelets;

2. deproclamation plasma;

3. serum;

4. calcium chloride.

Reagents:

1. 0.1 m solution of sodium oxalate;

2. 1/40 m solution of calcium chloride;

3. 0.15 m suspension of barium sulfate;

4. saline solution.

In silikonizirovannaya tube containing 0.6 ml of 0.1 m solution of sodium oxalate, recruited from Vienna dry point of 5.4 ml of blood. Caution the contents of the tubes are mixed. At the same time in another test tube take 1-2 ml of blood, from which they get the serum.

Preparation of suspension of platelets: oxalate blood into the silicone tube, centrifuged within 5-7 is in at 1500 rpm The plasma is sucked off silicone pipette to another silikonizirovannaya or plastic tube. Plasma enriched with platelets, centrifuged for 30 min at 3000 rpm Platelets settle to the bottom of the tube. The plasma, which contains almost no platelets, sucked off into a separate test tube, and platelets add saline solution, gently mixed and centrifuged again for 30 min at 3000 rpm/min saline solution is sucked off and the procedure of washing platelets again. After twice washing of platelets to the precipitate add them saline solution, by volume equal to 1/3 the amount of oxalate plasma collected for centrifugation. The contents are well mixed, obtaining a working suspension of platelets.

Preparation of the solution deproclamation plasma: 0.5-1 ml of plasma containing platelets, which was collected after centrifugation for 30 minutes at 3000 rpm, deplorability suspension of barium sulfate, as described above. Deproclamation plasma diluted with saline solution in a ratio of 1:4.

Preparation of serum diluent: 1-2 ml of venous blood collected in a dry test tube, placed into a water bath at 37°C for 2 hours. Serum separated from the clot by centrifugation and diluted with physiological what astorm in the ratio of 1:8.

Method of test: the number of the agglutination test tubes (7-8) in a water bath at 37°C contribute to 0.1 ml of plasma containing platelets, which remained after centrifugation for 30 minutes at 3000 rpm (part of this plasma is taken to gepatrombin). Separately in an empty test tube, also on a water bath, pour 0.3 ml of a suspension of platelets, 0.3 ml of a solution deproclamation plasma of 0.3 ml serum 0.3 ml 1/40 m solution of calcium chloride and include a stopwatch. Every minute 0.1 ml of this mixture and 0.1 ml 1/40 m solution of calcium chloride at the same time make one of a series of tubes containing plasma without platelets, and include another stopwatch. Shaking the tube, mark the clotting time of plasma. Minutely study continue to until thrombin time, plasma will not be as short as possible. It prothrombin time characterizes the activity of thromboplastin, and the moment at which curled mixture is the time of the formation of thromboplastin. Normal thromboplastin is formed on the 2-4 minute, and its activity is equal to 12-14 seconds.

When you register accelerate education and/or enhancing the activity of thromboplastin sick AG with IGT is assigned to the proposed medical complex.

The first component of the proposed method is feasible regular physical exercise is. One of the possible variants of physical activity is the following scheme of training.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, fill them calm dihan is eat.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day sick AG with IGT recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of the lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with IGT.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back with the ula, to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the foot, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not. delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the chest, abdomen, waist the Itza. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is reserved centuries the px. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and the delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying n the Mat, emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left to bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on the aliyah. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Sick AG with IGT is patient with impaired cardiovascular systems. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why a higher visionstatement persons suffering from hypertension with IGT should be implemented by the distribution of physical activity in small doses throughout the day. This method of increasing physical activity in patients with hypertension with IGT should be considered as a method of fractional loads.

Depending on the conditions of real life AH patients with IGT can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip-16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room the structure - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration, depending on conditions (cleaning, home services, cleaning, gardening work, and others).

In addition to physical exertion sick AG with IGT on stable antihypertensive therapy lisinopril 10 mg 1 time per day in the morning should be prescribed Metformin 500 mg 2 times a day, and daily swimming in the pool at least 20 minutes a day. This complex normalizes thromboelastography within 1 month, what is the basis of the reduction of the General pathological family history and the key to improving the quality and extending the life of AH patients with IGT.

Example. Patient K., 54 years old, suffering from hypertension with IGT for 6 years, in the morning on an empty stomach was taken blood from the cubital vein and determined the formation and activity of thromboplastin, which amounted to 1.6 min and 10.0, respectively. The patient had been assigned to the system daily physical activity, daily swimming in the pool at least 20 minutes a day, Metformin 500 mg 2 times daily, lisinopril 10 mg 1 time per day in the morning. The patient was examined every week after starting treatment. Simultaneously with the inspection was carried out the determination of the activity and the time of formation of thromboplastin.

After 1 month Le is placed in the patient activity and the formation of thromboplastin is normalized, accounting for 13 and 2.6 min, respectively. The patient is asked to comply with these recommendations in future.

The use of the proposed method to normalize thromboelastometry in cardiology and endocrinology will help to avoid many complications in patients with IGT, they reduce the number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.

Method optimization activity thromboelastometry in a short time in hypertensive patients with impaired glucose tolerance, including the appointment of dosed static and dynamic physical loads, daily swimming in the pool at least 20 minutes a day, the introduction of drugs Metformin 500 mg 2 times a day and lisinopril 10 mg 1 time per day in the morning for 1 month.



 

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2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology, and relates normalisation of cardio-vascular system functional reactivity in case of arterial hypertension with metabolic syndrome. For this purpose evaluation of CVS functional reactivity state under psychoemotional load is performed by registration of systolic diastolic, mean dynamic pressure and heart beat rate (HBR). On the basis of said data functional reactivity index (FRI) is determined before and after the load by the formula: FRI=(APav.dyn.x HBR)100 (conv.unit). If FRI is higher than 20 conv.units complex treatment including individually composed hypocaloric diet, which is calculated by formula taking into account sex, age and body weight, reasonably dosed static and dynamic physical loads, as well as introduction of valsartan 80 mg 1 time in the morning and pioglitazone 30 mg 1 time in the morning during not less than 3 months.

EFFECT: said complex of medicinal and non-medicinal therapy in combination with empirically selected treatment duration ensure normalisation of CVS functional reactivity in said group of patients due to potentiation of therapeutic effect of certain components of medicinal complex.

2 ex

FIELD: medicine.

SUBSTANCE: invention concerns normalising functional reactivity of cardiovascular system (CVS) in arterial hypertension, dyslipidemia, impaired glucose tolerance and abdominal obesity. That is ensured by estimating the condition of functional reactivity of the CVS in psychoemotional load, with recording systolic, diastolic, average dynamic pressure (PBav.dyn.) and heart rate (HR). These data are used to evaluate a functional responsiveness index (FRI) before and after stress by formula: FRI=(BPav.dyn. x HR)/100 (standard units). The post-load value PFR increased more than by 20 standard units requires the complex therapy including individually prescribed hypocaloric diet calculated by formula considering sex and age, rationally graduated static and dynamic physical activity, and introduction of losartan in a dose of 50 mg once in the morning, and pioglitazone in a dose of 30 mg once in the morning at least within 4 months.

EFFECT: such complex drug-induced and drug-free therapy combined with empirically prescribed treatment length provides normalisation of functional reactance of the CVS in the given group of the patients due to potentiation of therapeutic effect of separate components of an individual care.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely cardiology, and concerns normalising functional reactivity of cardiovascular system (CVS) in arterial hypertension and impaired glucose tolerance. That is ensured by estimating the condition of functional reactivity of the CVS in psychoemotional load by recording systolic, diastolic, average dynamic pressure (BPav.dyn.) and heart rate (HR). These data are used to evaluate a functional responsiveness index (FRI) before and after stress by formula: FRI=(BPav.dyn. x HR)/100(standard units). The post-load value PFR increased more than by 20 standard units requires the complex therapy including graduated static and dynamic physical activity, and introduction of irbesartan in a dose 150 mg in the morning once a day and pioglitazone in a dose 30 mg in the morning once a day at least within 4 months.

EFFECT: complex of drug-induced therapy combined with physical activity and empirically prescribed treatment length provides normalisation of functional reactivityof the CVS in the given group of the patients due to potentiation of therapeutic effect of the used drugs.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns treatments of the conditions caused by pathological metabolism of glucose and lipids. That is ensured by administration of cystamine or its salt in effective doses.

EFFECT: invention provides normalisation of such factors as C-peptide, uric acid, microalbumin, adiponectin.

17 cl, 11 tbl, 6 ex, 10 dwg

FIELD: medicine.

SUBSTANCE: present invention presents a preparation to reduce insulin resistance. The preparation contains 3-O-v-D-glucopyranosyl-4-methylergost-7-ene-3-ole, or an extract made with using an organic solvent, or an extract made with using hot water, or a drained liquid of a plant of Liliaceae family, or fraction thereof which contains this compound as an active component.

EFFECT: production of the preparation which is suitable for inhibition of adipocytokine production, particularly adipocytokine which cause insulin resistance, and for prevention of pathological conditions caused by insulin resistance, or simplification of clinical course of said pathological conditions.

9 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology and endocrinology, and concerns normalisation of thromboplastin formation in patients suffering from arterial hypertension with impaired glucose tolerance. That is ensured by integrated treatment including graduated static and dynamic physical exercises, and also introduction of pioglitazone in a dose 30 mg once in the morning and a lisinopril in a dose 10 mg once a day in the morning during 1.5 months.

EFFECT: complex of specific medical agents and physical activity combined with empirically specified duration of treatment provides normalisation of thromboplastin formation that in turn reduces risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns correction of blood microvesicle level in arterial hypertension with impaired glucose tolerance. That is ensured by integrated treatment including graduated physical exercises, and introduction of Fosinopril in a dose 10 mg once in the morning and pioglitazone in a dose 30 mg once in the morning. Therapeutic course is at least 7 weeks.

EFFECT: complex of drug-free modalities and specific pharmacological preparations combined with empirically specified time of treatment provides maintained optimum microvesicle level that in turn allows considerably reducing risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology and concerns correction of blood microvesicle level in arterial hypertension (AH) and pancreatic diabetes type II (PD II). That is ensured by integrated therapy involving graduated physical exercises, as well as introduction of lisinopril in a dose 10 mg once in the morning, amlodipine in a dose 5 mg once in the morning and pioglitazone in a dose 30 mg once in the morning for therapeutic course at least 7 weeks.

EFFECT: complex of specific medical preparations and physical exercises combined with empirically specified duration of treatment provides effective correction of blood microvesicle level and, thereby, reduced risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and endocrinology, and concerns normalisation of thrombocyte sensitivity to aggregation inducing factors in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by the integrated treatment including graduated physical activity, including daily swimming in a pool for at least 20 minutes a day, and administration of lisinopril in dosage 10 mg once a day in the morning and metformin in dosage 500 mg once a day. The therapeutic course is at least 5 weeks.

EFFECT: complex of specific medical products and physical activity combined with empirically prescribed length of treatment provides complete normalisation of thrombocyte sensitivity to aggregation inducing factors that in turn reduces risk of thrombolytic complications in the given group of patients.

1 ex, 3 dwg, 2 tbl

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