Method of quick optimisation of thrombocyte sensitivity to aggregation inducing factors in patients with arterial hypertension and impaired glucose tolerance

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology and endocrinology, and concerns normalisation of thrombocyte sensitivity to aggregation inducing factors in the patients with arterial hypertension and impaired glucose tolerance. That is ensured by the integrated treatment including graduated physical activity, including daily swimming in a pool for at least 20 minutes a day, and administration of lisinopril in dosage 10 mg once a day in the morning and metformin in dosage 500 mg once a day. The therapeutic course is at least 5 weeks.

EFFECT: complex of specific medical products and physical activity combined with empirically prescribed length of treatment provides complete normalisation of thrombocyte sensitivity to aggregation inducing factors that in turn reduces risk of thrombolytic complications in the given group of patients.

1 ex, 3 dwg, 2 tbl

 

The invention relates to medicine, namely to Hematology and endocrinology.

Analogues of the proposed method of normalization of the increased sensitivity of platelets to aggregation inducers in patients with arterial hypertension (AH) with impaired glucose tolerance (IGT) does not exist.

In the literature there are recommendations for physical training and swimming for the correction of metabolism in the elements of the metabolic syndrome (Diamond, VA, Supportive AV, Shlyakhto E.V., Krasilnikova H. Metabolic cardiovascular syndrome. SPb.: Ed. SPb. (MCM). 1999. - 208 S.).

Metformin is used in patients with IGT and diabetes type 2 diabetes to reduce insulin resistance.

For the correction of high blood pressure in hypertension with IGT used lisinopril.

However, never before medical complex consisting of dosed physical activity, swimming, Metformin and lisinopril, have not been applied in patients with IGT to normalize available to them increased sensitivity of platelets to the combinations of inductors - diphosphate (ADP)+epinephrine, ADP+collagen, adrenaline+collagen, ADP+adrenaline+collagen, ADP+adrenaline+thrombin, can lead to the development of hyperaggregation and macrothrombocytopenia vessels, causing a deterioration in the trophic tissue, the risk of heart attacks and insult is in persons with hypertension and IGT.

The aim of the invention is the normalization of the increased sensitivity of platelets to aggregation inducers in patients with IGT.

The essence of the proposed method lies in the fact that after blood collection, its stabilization by sodium citrate 3.8 percent, the separation of blood into plasma and erythrocytes by centrifugation to obtain platelet-rich plasma (BTP) on slides conduct tests on platelet aggregation with multiple combinations of inductors. Visual assessment of platelet aggregation under these conditions allows a small volume of 0.02 ml) of plasma and a small amount of the inductors assess the sensitivity of platelets to aggregation inducers on the development of the aggregation process. With increasing their sensitivity to inducers registered on reducing the need for aggregation dose of the inducer in the application of double and triple combinations, possible to perform correction by assigning at least 5 weeks dosed physical activity, daily swimming in the pool at least 20 minutes a day and drugs Metformin 500 mg 2 times a day, and lisinopril 10 mg 1 time per day in the morning.

The inventive method is carried out as follows. After taking the patient 9 ml of blood in sodium citrate 3.8% in the ratio of 9:1, it is centrifuged for 5 min at 1000 rpm to obtain BTP. Part of the plasma are selected, the remaining centrifuged at 3000 rpm for 20 min, receiving platelet-poor plasma (Betp). BTP standardise the number of platelets by dilution of the original BTP autologous sample Betp (up to 200·109/l).

The standardized volume of plasma is withdrawn from the calculation of 0.02 ml of plasma for each inductor and investigated the combination of inductors. The remaining volume of plasma can be used for other hematological and biochemical investigations.

Selected standardized volume of plasma on a glass slide cause of 0.02 ml of plasma and different pipette solutions of two or three inductors (Fig 1 and 2) with a total volume equal to the volume of plasma. When using one inductor volume is 0.02 ml, when using two of 0.01 ml, three on 0,007 ml.

As agonists can be used ADP, collagen, thrombin, epinephrine in combination ADP+epinephrine, ADP+collagen, adrenaline+collagen, ADP+adrenaline+collagen, ADP+adrenaline+thrombin required dose which in this case were lower than for stand-alone usage, and for any triple combination of inductors is even lower. Dose inductors required for aggregation in patients with hypertension and IGT, and the article concludes that the minimum dose inductors have lower than standard (table 1 and 2)capable of inducing platelet aggregation in healthy people. Glass wand mix plasma with inducto the AMI and include a stopwatch. The mixture is stirred so that the liquid held a circle with a diameter of about 2 cm (figure 3). Shaking the glass in a circular motion in transmitted light illuminator on a black background is watched through a magnifying glass for the occurrence of aggregates. With the appearance of distinct units, the enlightenment of the solution and the adhesion of some units to the glass stopwatch off, fixing the time of platelet aggregation.

From the material presented, it follows that in comparison with the stimulation of one inductor in healthy people when using in patients with hypertension and IGT and especially two and three inductors require a much smaller concentration of agonists for the development aggregation that is probably due to the involvement of multiple mechanisms of activation. It should be noted that the study of the aggregation ability of blood platelets with two and three inductors to simulate events that occur in blood flow in the damaged area of the vessel and the initiation of the process of hemostasis. Thus, in patients with hypertension and IGT was found regularities expressed more than healthy people because of the increased sensitivity of platelets to aggregation inducers with a lower concentration of inductors required for the development of the aggregation of blood platelets.

Table 1
The standard dose of inductors, causing platelet aggregation when they are a stand-alone application.
InductorsADP, MAdrenaline, MCollagen, the main breeding suspensionThrombin, IU/ml
Dose0,5·10-45·10-61:20,125

Table 2
Minimum article concludes that concentrations of inducers aggregation in healthy individuals and patients with arterial hypertension with impaired glucose tolerance in dual and triple combination.
Combinations of inducers of platelet aggregation
Category surveyedADP, MAdrenaline, MCollagen, the main breeding suspensionThrombin, IU/ml
One agonista the with two agonistswith the same agonistwith two agonistswith the same agonistwith two agonistswith the same agonistwith two agony
hundred
Healthy people, n=2110-65·10-72,5·10-710-71:41:50,1000,090
Sick people, n=10710-75·10-85,0·10-85-10-81:71:80,0800,070

From tables 1 and 2 it follows that the minimum causing aggregation dose of inductors, with the combined use of them is significantly lower than in standard conditions when using effects on platelets of the same agonist. At simultaneous presence in BTP three inductors dose required for aggregation, even lower than in the case of two inducto the RC. Moreover, in hypertensive patients with impaired glucose tolerance, these values are even lower, which indicates they expressed the activation of platelets. Simultaneous use of multiple inductors brings our understanding of the required minimum concentration of inducers in real conditions at the initiation of hemostasis in blood vessels of a person.

To diagnose an increased sensitivity to inducers aggregation in patients with IGT possible with the development of platelet aggregation when using isolated inductors at doses below those specified in table 1, and in their double and triple combination listed below in table 2 for healthy people. In patients with IGT typical concentrations are given in table 2.

When the detection sensitivity of platelets to aggregation inducers sick AG with IGT are appointed for 5 weeks dosed physical load, daily swimming in the pool for at least 20 minutes a day and drugs Metformin 500 mg 2 times a day, and lisinopril 10 mg 1 time per day in the morning.

The inventive method is carried out as follows.

The first component of the proposed method is feasible regular physical exercise. A possible variation of physical activity is provided below.

In real life you can implement the three forms of physical activity: 1) morning gigienicheskie the gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in aired. the premise. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning gymnastics. should evoke a sense of vitality, increase activity, improve well-being and health.

When bad samochwal the AI, the development of shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day sick AG with IGT recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of the lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with IGT.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

pragnienie 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, feet apart is widely hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - inhale, tilt tulo is ische, and the hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and son-in-law in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When STP is assured - exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands pubescent. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

pragnienie 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and the delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, the ATEM to go. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the leg with a pen is carrying on her the gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load for 1-2 minutes

3. Fractional exercise during the day.

Sick AG with IGT is patient with disorders of the cardiovascular system. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why increasing the physical activity of persons suffering from hypertension with IGT should be implemented by the distribution of physical activity in small doses throughout the day. This method of increasing physical activity in patients with hypertension with IGT should be considered as a method fractional load the K.

Depending on the conditions of real life AH patients with IGT can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home maintenance,work on cleaning the territory, garden work and other).

The second component of the proposed method - daily swimming in the pool at least 20 minutes a day, the third purpose of Metformin 500 mg 2 times a day, the fourth component is lisinopril 10 mg 1 time per day in the morning

The method allows to normalize the sensitivity of platelets to aggregation inducers in patients with IGT during the 5 weeks of treatment, bringing it to the level characteristic of healthy persons subject to subsequent data to the patient recommendations it is possible to eliminate the increased sensitivity of platelets of individuals with hypertension and IGT to the inductors aggregation that will significantly reduce their risk of thrombotic complications, strokes and heart attacks.

Example. Patient A., 42 years old, with hypertension and impaired glucose tolerance, in the dispensary of hypertension in the clinic at the place of residence examined routinely.

The level of aggregation of platelets, the patient was evaluated with a combination of inductors: ADP+epinephrine, ADP+collagen, adrenaline+collagen, ADP+collagen+epinephrine, ADP+adrenaline+thrombin. Minimum article concludes that aggregate concentration in the case of two inductors accounted for ADF - 10-7M, collagen - 1:7 dilution of the primary suspension of collagen, adrenaline - 5,0·10-8M, thrombin - 0,080 IU/ml In case one is belt use three inductors their minimum concentration was lower. For ADP - 5,0·10-8M, for collagen - 1:8 dilution of the primary suspension, adrenaline - 5,0·10-8M, thrombin - 0,070 IU/ml

Development of platelet aggregation with minimal article concludes that doses of inductors indicates a violation (activation) aggregation of platelets.

The patient was assigned adequate hypotensive therapy lisinopril 10 mg 1 time a day, dosed physical load, daily swimming in the pool at least 20 minutes a day and Metformin 500 mg 2 times a day. This allowed after 5 weeks of treatment lead article concludes that the minimum dose of inductors, causing platelet activation to the level of healthy people. Minimum article concludes that aggregate concentration in the case of two inductors accounted for ADF - 10-6M, collagen - 1:4 dilution of the primary suspension of collagen, epinephrine is 2.5·10-7M, thrombin - 0,100 IU/ml In the case of the simultaneous use of three inductors their minimum concentration was lower. For ADP -5·10-7M, for collagen - 1:5 dilution of the primary suspension, adrenaline - 10-7M, thrombin - 0,090 IU/ml

Thus, activation of platelets in response only to the article concludes that doses of inductors typical of healthy humans suggest that the normal function of platelets in patients.

The patient was recom is dovana continue to comply with these recommendations.

A method for rapid optimization of the sensitivity of platelets to aggregation inducers in hypertensive patients with impaired glucose tolerance, including the assignment for at least 5 weeks dosed physical activity, daily swimming in the pool at least 20 minutes a day, the introduction of lisinopril 10 mg 1 time a day, morning and Metformin 500 mg 2 times a day.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to cardiology, and concerns normalising the functional responsiveness of cardiovascular system in elderly and senile patients suffering arterial hypertension and metabolic syndrom. That is ensured by estimating the condition of functional reactivity of the CVS in psychoemotional load by recording systolic, diastolic, average dynamic pressure (BPav.dyn.) and heart rate (HR). These data are used to evaluate a functional responsiveness index (FRI) before and after load by formula: FRI=(BPav.dyn. x HR)100 (standard units). The value PFR increased more than by 20 standard units requires the complex therapy including individually prescribed hypocaloric diet calculated by formula considering sex and age and body weight, graduated static and dynamic physical activity, and introduction of irbesartan in dosage 150 mg once in the morning, and pioglitazone in dosage 30 mg once in the morning at least for 3 months.

EFFECT: complex drug-induced and drug-free therapy combined with empirically prescribed treatment length provides normalisation of functional responsiveness of the CVS in the given group of patients due to potentiation of therapeutic effect of separate components of an individual care.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology, and relates normalisation of cardio-vascular system functional reactivity in case of arterial hypertension with metabolic syndrome. For this purpose evaluation of CVS functional reactivity state under psychoemotional load is performed by registration of systolic diastolic, mean dynamic pressure and heart beat rate (HBR). On the basis of said data functional reactivity index (FRI) is determined before and after the load by the formula: FRI=(APav.dyn.x HBR)100 (conv.unit). If FRI is higher than 20 conv.units complex treatment including individually composed hypocaloric diet, which is calculated by formula taking into account sex, age and body weight, reasonably dosed static and dynamic physical loads, as well as introduction of valsartan 80 mg 1 time in the morning and pioglitazone 30 mg 1 time in the morning during not less than 3 months.

EFFECT: said complex of medicinal and non-medicinal therapy in combination with empirically selected treatment duration ensure normalisation of CVS functional reactivity in said group of patients due to potentiation of therapeutic effect of certain components of medicinal complex.

2 ex

FIELD: medicine.

SUBSTANCE: invention concerns normalising functional reactivity of cardiovascular system (CVS) in arterial hypertension, dyslipidemia, impaired glucose tolerance and abdominal obesity. That is ensured by estimating the condition of functional reactivity of the CVS in psychoemotional load, with recording systolic, diastolic, average dynamic pressure (PBav.dyn.) and heart rate (HR). These data are used to evaluate a functional responsiveness index (FRI) before and after stress by formula: FRI=(BPav.dyn. x HR)/100 (standard units). The post-load value PFR increased more than by 20 standard units requires the complex therapy including individually prescribed hypocaloric diet calculated by formula considering sex and age, rationally graduated static and dynamic physical activity, and introduction of losartan in a dose of 50 mg once in the morning, and pioglitazone in a dose of 30 mg once in the morning at least within 4 months.

EFFECT: such complex drug-induced and drug-free therapy combined with empirically prescribed treatment length provides normalisation of functional reactance of the CVS in the given group of the patients due to potentiation of therapeutic effect of separate components of an individual care.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely cardiology, and concerns normalising functional reactivity of cardiovascular system (CVS) in arterial hypertension and impaired glucose tolerance. That is ensured by estimating the condition of functional reactivity of the CVS in psychoemotional load by recording systolic, diastolic, average dynamic pressure (BPav.dyn.) and heart rate (HR). These data are used to evaluate a functional responsiveness index (FRI) before and after stress by formula: FRI=(BPav.dyn. x HR)/100(standard units). The post-load value PFR increased more than by 20 standard units requires the complex therapy including graduated static and dynamic physical activity, and introduction of irbesartan in a dose 150 mg in the morning once a day and pioglitazone in a dose 30 mg in the morning once a day at least within 4 months.

EFFECT: complex of drug-induced therapy combined with physical activity and empirically prescribed treatment length provides normalisation of functional reactivityof the CVS in the given group of the patients due to potentiation of therapeutic effect of the used drugs.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns treatments of the conditions caused by pathological metabolism of glucose and lipids. That is ensured by administration of cystamine or its salt in effective doses.

EFFECT: invention provides normalisation of such factors as C-peptide, uric acid, microalbumin, adiponectin.

17 cl, 11 tbl, 6 ex, 10 dwg

FIELD: medicine.

SUBSTANCE: present invention presents a preparation to reduce insulin resistance. The preparation contains 3-O-v-D-glucopyranosyl-4-methylergost-7-ene-3-ole, or an extract made with using an organic solvent, or an extract made with using hot water, or a drained liquid of a plant of Liliaceae family, or fraction thereof which contains this compound as an active component.

EFFECT: production of the preparation which is suitable for inhibition of adipocytokine production, particularly adipocytokine which cause insulin resistance, and for prevention of pathological conditions caused by insulin resistance, or simplification of clinical course of said pathological conditions.

9 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to cardiology and endocrinology, and concerns normalisation of thromboplastin formation in patients suffering from arterial hypertension with impaired glucose tolerance. That is ensured by integrated treatment including graduated static and dynamic physical exercises, and also introduction of pioglitazone in a dose 30 mg once in the morning and a lisinopril in a dose 10 mg once a day in the morning during 1.5 months.

EFFECT: complex of specific medical agents and physical activity combined with empirically specified duration of treatment provides normalisation of thromboplastin formation that in turn reduces risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns correction of blood microvesicle level in arterial hypertension with impaired glucose tolerance. That is ensured by integrated treatment including graduated physical exercises, and introduction of Fosinopril in a dose 10 mg once in the morning and pioglitazone in a dose 30 mg once in the morning. Therapeutic course is at least 7 weeks.

EFFECT: complex of drug-free modalities and specific pharmacological preparations combined with empirically specified time of treatment provides maintained optimum microvesicle level that in turn allows considerably reducing risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology and concerns correction of blood microvesicle level in arterial hypertension (AH) and pancreatic diabetes type II (PD II). That is ensured by integrated therapy involving graduated physical exercises, as well as introduction of lisinopril in a dose 10 mg once in the morning, amlodipine in a dose 5 mg once in the morning and pioglitazone in a dose 30 mg once in the morning for therapeutic course at least 7 weeks.

EFFECT: complex of specific medical preparations and physical exercises combined with empirically specified duration of treatment provides effective correction of blood microvesicle level and, thereby, reduced risk of thrombotic complications in given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology and endocrinology, and concerns normalisation of thrombocyte sensitivity to aggregation inducers in patients suffering from arterial hypertension with impaired glucose tolerance. That is ensured by integrated therapy including graduated physical exercises, and introduction of lisinopril in a dose 10 mg once a day in the morning and pioglitazone in a dose 30 mg once a day in the morning. Therapeutic course lasts for at least 6 weeks. The method enables complete normalisation of thrombocyte sensitivity to aggregation inducers owing to potentiation of therapeutic effect of certain components of integrated therapy.

EFFECT: that in turn allows reducing risk of thrombotic complications in given group of patients.

1 ex, 3 dwg, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be used for motor function recovery in patients with wound dystrophy of spinal marrow. The method involves exercise therapy that is combined with administration of Phenotropil in single dosage 200 mg in the morning for 30 days.

EFFECT: method allows improving effectiveness in invalids to train motor functions of sitting, standing and walking due to reduced depression and anxiety, therefore higher tolerance to physical activity and pain while making therapeutic exercises.

4 ex

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