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Mass spectrometre |
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IPC classes for russian patent Mass spectrometre (RU 2393579):
Time-of-flight mass spectrometre / 2381591
Proposed invention relates to mass spectrometry with orthogonal entry of ions and is widely used in organic and bioorganic chemistry, immunology, biotechnology and medicine when ionising analysed substances using an electron impact method, electrospray etc. The time-of-flight mass spectrometre consists of an electrospray type ion source, an orthogonal ion accelerator (pulser), which includes regions for accumulation and acceleration of ions, field-free drift space, two-stage mirror and detector. The accumulation region of the pulser is made in form of a monopole whose grounded electrode edge is combined with the grounded grid of the acceleration region. There is an ion exit slit in the grounded electrode edge of the monopole.
Mass-sensitive selective concentrator for ion mobility spectroscopy (ims) / 2379678
Invention relates to analytical instruments, particularly, to devices intended for preliminary concentration of analyzed sample and combined with analytical instrument that can be used to produce fast-operation analyzers of poisonous or explosive substance concentration in air. Proposed concentrator comprises analyzed sample fast-desorption absorbing element and acoustic transducer with its output signal depending upon mass of absorbed sample. Acoustic transducer represents a piezoelectric plate-sound conductor with two built-in interdigital electromechanical transducers (IDT), designed to excite and receive surface acoustic waves (SAW). While absorbing element represents a film made from molecular imprinting polymer applied onto said plate-sound receiver surface and consisting of two sections, i.e. small-area detecting section located on SAW propagation line, and larger-area concentrating section located outside acoustic line. Said concentrating section can comprise two additional sections to double as SAW-absorbing coatings. To this end, said additional sections are arranged on plate-sound receiver surface, on SAW propagation line outside the space between IDT.
Mass spectrometer for macromolecule analysis / 2332748
Mass spectrometer contains holder with analysed substance, ionisator and supplier of macromolecules to mass analyser, and detector. Mass analyser is connected to holder with analysed substance, and detector is based on matrix of micromechanical cantilevers providing determination of interaction time point and point where accelerated macromolecule contacts with petal surface of micromechanical cantilever, providing macromolecule pulse transfer to micromechanical cantilever petal, and following deviation of petal by the distance determined by weight and energy of macromolecule. Thus detector is implemented within consistently optically connected emitting sources, collimating optics, micromechanical cantilever matrix, projecting optics and photodetector, while micromechanical cantilever matrix thereof is designed as detector substrate where micromechanical cantilevers are mounted, thus micromechanical cantilever is designed as part of leg, arm, reflecting layer. Micromechanical cantilever matrix is multielement.
Method and device for identification of organic compounds / 2329563
Invention is related to the field of gas analysis, in particular of vapours of explosive, narcotic and poisoning substances. Method of organic compounds identification consists in measurement of volt-ampere characteristics with application of surface-ionisation source of ions, in which measurement of volt-ampere dependence is carried out in interval of voltages "thermal emitter of ions - electrode for ion current control" from U1 to U4, volt-ampere dependence section is separated from U2 to U3>U1, in which value of current of organic compounds ions quadratically depends on value of voltage "thermal emitter of ions - electrode for ion current control", at that U1 and U4 are selected based on conditions U4>U3, U1<U2, at that volt-ampere dependence is used for determination of value of organic compounds ions drift mobility and/or for determination of energy activation value of organic compounds molecules ionisation on thermal emitter surface, at that for determination of organic compounds ions drift mobility value section is used from U2 to U3 of volt-ampere characteristic, and for determination of energy activation value of organic compounds molecules ionisation section is used from U3 to U4 of volt-ampere characteristic. Device is suggested for identification of organic compounds, which contains two structurally identical surface-ionisation sources of organic compounds ions, at that inlet openings of channels of nozzles for intake of analysed air flows of the first and second sources of ions are combined into common channel of common nozzle for intake of analysed air flow.
Ion mobility spectrometer / 2328791
Ion mobility spectrometer contains the neoformation chamber with installed ion source, drift chamber with the ion collector and aperture mesh, ejecting electrode and the mesh gate which form the ejection area, holes for supplying the mixture of the analised substance with carrier gas, and drifting gas and for outputting the drift gas and the mixture of the analised substance with carrier gas. The chamber of ion-formation with the ion source is placed out of the ejection area and connected with it via adapter with the canal for ion transportation; at that, the ion-formation chamber has the potential of the mesh gate. The adaptor canal has the conical shape, at the ion-formation chamber, which becomes slit-like at the ejection area. The planes of the slit-like canal are parallel to the mesh gate. The length of the slit-like canal is selected so as to guide the ion and carrier gas flow along the ejecting electrode and the mesh gate. The length of the slit-like canal is more or equal to the canal's width, and the canal's width is equal to or less than the distance between the mesh gate and the ejecting electrode.
Mass selective device and analysis method for drift time of ions / 2327245
Invention pertains to the field of dynamic mass analysis of charged particles in alternating HF fields. The mass-selective method of separating ions is based on the use of an analyser, consisting of two flat parallel electrodes with linear-discrete and anti-phased HF potential distributions on the Y axis and a flat earthed electrode, and a limiting electrode with values y≥0. The discrete electrodes are made in the form of capacitor or inductive linear HF voltage dividers. Applied to the electrodes are two anti-phased HF voltages with constant amplitude Um and frequency, ω for which a linear alternating electrical field is formed in the analyser on the X and Y axis. Ions are put into the analyser through the opening in the flat earthed electrode with initial coordinates xn>0, уn=0 and initial velocities vu, inversely proportional to the masses, m of the analysed ions. Ions on the X and Y axes have almost harmonic oscillations with the same amplitude уm and period T, proportional to mass m. During the analysis period the x coordinate of the ions changes to the opposite x(tA)=-xn, while the y coordinate becomes equal to y(tA)=0. The sorted out ions in accordance of their mass m, successively pass into the analyser and reach the registration system.
Dust impact mass spectrometer / 2326465
Invention relates to the instrument engineering, automation means, and control systems, namely, to the space research area. The dust impact mass spectrometer contains a hemispheric target with one opening in the middle of its surface, which increases the probability of target impact with a micrometeorite at the same dimensions of the mass spectrometer. The accelerating gap is a limited by a hemispheric target and a hemispheric grid, located concentrically, which provides equal ion trajectory lengths, thus eliminating the measurement result dependence on the impact location and increases the measurement result reliability. The parabolic reflector focuses ions into a parallel beam directed exactly to the hemispheric target opening.
Transit-time method for metering charge and mass composition of plasma ions / 2314594
Proposed method involves immersion of drift tube into plasma followed by acceleration of ions by applying negative-polarity voltage pulse across drift tube, pulse length being shorter than its transit time within drift tube carrying analyzed plasma accelerated ions at highest Z/Mi ratio, where Z is degree of ion charge in plasma; Mi is ion mass; this is followed by separating ions with respect to their mass, charge, and energy as they are conveyed through equipotential space of drift tube, as well as measurement of ion current pulse at drift tube outlet; then second measurement similar to first one is made but for different length of negative-polarity voltage pulse supplied to drift tube; charge and mass composition of plasma ions is evaluated by subtracting results of measuring ion current pulses at outlet of drift tube obtained at different lengths of negative-polarity voltage pulses.
Transit-time mass spectrometer / 2295797
Proposed mass spectrometer that can be used for solving problems in organic chemistry, biochemistry, immunology, medicine, biotechnology, environment control, for evaluating composition and properties of materials in industry and scientific research has pulsed ion source, drift space with two flat braking-field wire-net capacitors and detector installed in tandem at its end is provided with second drift space formed by common electrodes of flat wire-net capacitors spaced along device axis; potential of second drift space is braking one with respect to first drift space.
Analyzer of energies of charged particles / 2294579
Analyzer of charged particles energy contains sample (emitting charged particles), external electrode and internal electrode with two circular slits and detecting system. Axial and radial gradients of energy analyzer field potential are synchronized along movement route of charged particles by setting appropriate configuration of equipotential surfaces of analyzer electrodes.
Ion spectrum measurement process and transit-time ion spectrometer / 2266587
Charge and mass composition is measured by accelerating ions in accelerating gap formed in vacuum chamber between input end of drift tube and plasma when negative-polarity voltage pulse of length shorter than transit time in drift tube of accelerated ions of plasma being analyzed is applied to drift tube at maximal Z/Mi ratio, where Z is ion charge in plasma; Mi is ion mass. Voltage pulse is supplied from negative-polarity accelerating-voltage pulse source whose high-voltage lead is electrically connected to drift tube and other lead, to vacuum-chamber ground. When in transit, accelerated ions are divided within drift tube into mass, charge, and energy clots and separated clots are recorded by detector.
Analyzer of energies of charged particles / 2294579
Analyzer of charged particles energy contains sample (emitting charged particles), external electrode and internal electrode with two circular slits and detecting system. Axial and radial gradients of energy analyzer field potential are synchronized along movement route of charged particles by setting appropriate configuration of equipotential surfaces of analyzer electrodes.
Transit-time mass spectrometer / 2295797
Proposed mass spectrometer that can be used for solving problems in organic chemistry, biochemistry, immunology, medicine, biotechnology, environment control, for evaluating composition and properties of materials in industry and scientific research has pulsed ion source, drift space with two flat braking-field wire-net capacitors and detector installed in tandem at its end is provided with second drift space formed by common electrodes of flat wire-net capacitors spaced along device axis; potential of second drift space is braking one with respect to first drift space.
Transit-time method for metering charge and mass composition of plasma ions / 2314594
Proposed method involves immersion of drift tube into plasma followed by acceleration of ions by applying negative-polarity voltage pulse across drift tube, pulse length being shorter than its transit time within drift tube carrying analyzed plasma accelerated ions at highest Z/Mi ratio, where Z is degree of ion charge in plasma; Mi is ion mass; this is followed by separating ions with respect to their mass, charge, and energy as they are conveyed through equipotential space of drift tube, as well as measurement of ion current pulse at drift tube outlet; then second measurement similar to first one is made but for different length of negative-polarity voltage pulse supplied to drift tube; charge and mass composition of plasma ions is evaluated by subtracting results of measuring ion current pulses at outlet of drift tube obtained at different lengths of negative-polarity voltage pulses.
Dust impact mass spectrometer / 2326465
Invention relates to the instrument engineering, automation means, and control systems, namely, to the space research area. The dust impact mass spectrometer contains a hemispheric target with one opening in the middle of its surface, which increases the probability of target impact with a micrometeorite at the same dimensions of the mass spectrometer. The accelerating gap is a limited by a hemispheric target and a hemispheric grid, located concentrically, which provides equal ion trajectory lengths, thus eliminating the measurement result dependence on the impact location and increases the measurement result reliability. The parabolic reflector focuses ions into a parallel beam directed exactly to the hemispheric target opening.
Mass selective device and analysis method for drift time of ions / 2327245
Invention pertains to the field of dynamic mass analysis of charged particles in alternating HF fields. The mass-selective method of separating ions is based on the use of an analyser, consisting of two flat parallel electrodes with linear-discrete and anti-phased HF potential distributions on the Y axis and a flat earthed electrode, and a limiting electrode with values y≥0. The discrete electrodes are made in the form of capacitor or inductive linear HF voltage dividers. Applied to the electrodes are two anti-phased HF voltages with constant amplitude Um and frequency, ω for which a linear alternating electrical field is formed in the analyser on the X and Y axis. Ions are put into the analyser through the opening in the flat earthed electrode with initial coordinates xn>0, уn=0 and initial velocities vu, inversely proportional to the masses, m of the analysed ions. Ions on the X and Y axes have almost harmonic oscillations with the same amplitude уm and period T, proportional to mass m. During the analysis period the x coordinate of the ions changes to the opposite x(tA)=-xn, while the y coordinate becomes equal to y(tA)=0. The sorted out ions in accordance of their mass m, successively pass into the analyser and reach the registration system.
Ion mobility spectrometer / 2328791
Ion mobility spectrometer contains the neoformation chamber with installed ion source, drift chamber with the ion collector and aperture mesh, ejecting electrode and the mesh gate which form the ejection area, holes for supplying the mixture of the analised substance with carrier gas, and drifting gas and for outputting the drift gas and the mixture of the analised substance with carrier gas. The chamber of ion-formation with the ion source is placed out of the ejection area and connected with it via adapter with the canal for ion transportation; at that, the ion-formation chamber has the potential of the mesh gate. The adaptor canal has the conical shape, at the ion-formation chamber, which becomes slit-like at the ejection area. The planes of the slit-like canal are parallel to the mesh gate. The length of the slit-like canal is selected so as to guide the ion and carrier gas flow along the ejecting electrode and the mesh gate. The length of the slit-like canal is more or equal to the canal's width, and the canal's width is equal to or less than the distance between the mesh gate and the ejecting electrode.
Method and device for identification of organic compounds / 2329563
Invention is related to the field of gas analysis, in particular of vapours of explosive, narcotic and poisoning substances. Method of organic compounds identification consists in measurement of volt-ampere characteristics with application of surface-ionisation source of ions, in which measurement of volt-ampere dependence is carried out in interval of voltages "thermal emitter of ions - electrode for ion current control" from U1 to U4, volt-ampere dependence section is separated from U2 to U3>U1, in which value of current of organic compounds ions quadratically depends on value of voltage "thermal emitter of ions - electrode for ion current control", at that U1 and U4 are selected based on conditions U4>U3, U1<U2, at that volt-ampere dependence is used for determination of value of organic compounds ions drift mobility and/or for determination of energy activation value of organic compounds molecules ionisation on thermal emitter surface, at that for determination of organic compounds ions drift mobility value section is used from U2 to U3 of volt-ampere characteristic, and for determination of energy activation value of organic compounds molecules ionisation section is used from U3 to U4 of volt-ampere characteristic. Device is suggested for identification of organic compounds, which contains two structurally identical surface-ionisation sources of organic compounds ions, at that inlet openings of channels of nozzles for intake of analysed air flows of the first and second sources of ions are combined into common channel of common nozzle for intake of analysed air flow.
Mass spectrometer for macromolecule analysis / 2332748
Mass spectrometer contains holder with analysed substance, ionisator and supplier of macromolecules to mass analyser, and detector. Mass analyser is connected to holder with analysed substance, and detector is based on matrix of micromechanical cantilevers providing determination of interaction time point and point where accelerated macromolecule contacts with petal surface of micromechanical cantilever, providing macromolecule pulse transfer to micromechanical cantilever petal, and following deviation of petal by the distance determined by weight and energy of macromolecule. Thus detector is implemented within consistently optically connected emitting sources, collimating optics, micromechanical cantilever matrix, projecting optics and photodetector, while micromechanical cantilever matrix thereof is designed as detector substrate where micromechanical cantilevers are mounted, thus micromechanical cantilever is designed as part of leg, arm, reflecting layer. Micromechanical cantilever matrix is multielement.
Mass-sensitive selective concentrator for ion mobility spectroscopy (ims) / 2379678
Invention relates to analytical instruments, particularly, to devices intended for preliminary concentration of analyzed sample and combined with analytical instrument that can be used to produce fast-operation analyzers of poisonous or explosive substance concentration in air. Proposed concentrator comprises analyzed sample fast-desorption absorbing element and acoustic transducer with its output signal depending upon mass of absorbed sample. Acoustic transducer represents a piezoelectric plate-sound conductor with two built-in interdigital electromechanical transducers (IDT), designed to excite and receive surface acoustic waves (SAW). While absorbing element represents a film made from molecular imprinting polymer applied onto said plate-sound receiver surface and consisting of two sections, i.e. small-area detecting section located on SAW propagation line, and larger-area concentrating section located outside acoustic line. Said concentrating section can comprise two additional sections to double as SAW-absorbing coatings. To this end, said additional sections are arranged on plate-sound receiver surface, on SAW propagation line outside the space between IDT.
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FIELD: physics. SUBSTANCE: proposed device comprises ion mobility spectrometre, ion-optical lenses, interface of differential pump-out, time-of-flight analyser and ion detector. Note here that ion mobility spectrometer comprises ion formation chamber, drift tube with aperture element, ion gate, drift zone, gas curtain zone of mass spectrometre, drift gas inlet and power supply. Ion source of mass spectrometre comprises axially symmetric casing with walls accommodating radially-directed sample intake and ionisation device with ionising agents. Point whereat said intake device axes intersect is located opposite the apex of aperture element representing a convex-face wall with hole to intake ion at its top. Time of flight analyser represents a cylindrical condenser accommodating assembly of orthogonal acceleration with ejector electrode and ion detector. EFFECT: higher sensitivity and reduced sizes. 4 cl, 3 dwg
The invention relates to a method of separating ions, to a method of separation mass spectrometry, namely the charged particle spectrometers, spectrometers, operating on the principle of measuring the time of flight of ions, in particular to the composition of the liquid and gas samples, and can be applied in medicine, pharmaceuticals, forensics, analysis of environmental objects. Known mass spectrometer containing an ion mobility spectrometer, the ion-optical lens, the interface of differential pumping, time-of-flight analyzer of the type of mass reflectron and the ion detector. U.S. patent No. 7095014, IPC B01D 59/44, 2006. Known time-of-flight mass spectrometer containing the ion source, the device fragmentation ions, mass reflectron, position-sensitive detector, coupled with time-of-flight mass spectrometer, a time controller, the data processing system. U.S. patent No. 7084395, IPC H01J 49/40, 2006. The prototype. And similar, and the prototype have a common disadvantage, because mass reflectron causes limitations in sensitivity due to low tokophobia and restrictions on duty cycle continuous ion flow. This invention eliminates these drawbacks. The technical result of the invention is to increase the sensitivity and decrease the size of the device. The technical result achieved is is the fact that in mass spectrometer containing an ion mobility spectrometer, the ion-optical lens, the interface of differential pumping, time-of-flight analyzer and ion detector, the ion mobility spectrometer includes a camera inobtrusive, drift tube with the aperture element, the ion gate, the drift region, the region of the gas curtain mass spectrometer, enter the drift gas, the power supply system, the ion source of the mass spectrometer includes a housing ionizer axially symmetric forms on the inside of the ionizer is installed radially directed input device and ionization of the sample analyte with ionizers, the point of intersection of the axes of the input device is positioned opposite the top of the aperture element made in the form of a wall of a convex shape with an opening for entry of ions at its peak and time-of-flight analyzer is made in the form of a cylindrical capacitor, in which the node is installed orthogonal acceleration eject electrode and the ion detector. In the linear inprovide installed the screen with the possibility of changing its potential. Input devices and ionization of the sample analyte contains ionizers in the form of electronicdevices, and/or ionizer by corona discharge, and/or photoinitiator, and/or a laser ionizer, and/or enter the spray of the liquid sample, and/or gases enter the x samples and/or substrates for desorption from the surface. The invention is illustrated in the drawings, 1-3. 1 schematically shows a device for analyzing gas samples, where 1 - electroepilation (in OFF position), 2 - ionizer based on corona discharge (in ON position), 2.1 - needle ionizer by corona discharge, 3 - photoionization (in ON position), 4 - input device of the gas sample (in ON position), 5 - spray liquid samples (in OFF position), 6 - ionizer housing, 7 - camera inobtrusive, 8 - wall convex form, 9 - hole at the top of the convexity of the wall, 10 - region desolvatation 11 - the ion inlet gate or hub, 12 - region drift, 13 - discharge ion gate, 14 - heater, 15 - channel pumping the drift gas and the sample, 16 - channel input of the cooled air to operate at a lower temperature or a rapid change in temperature mode, 17 - channel output of the cooled air, 18 - body mass spectrometer ion mobility, 19 - an analyte, 20 - gas region of the veil of the mass spectrometer, 20.1 - gas curtain of the mass spectrometer used as the drift gas 21 - the first step interface differential pumping mass spectrometer, 21.1 - hole of the first stage of the interface of differential pumping, 22 - second level interface of differential pumping, 22.1 - skimmer second stage of the interface differential the first pumping, 22.2 - hole of the second stage of the interface of differential pumping, 22.3 ion optics of the second stage of the interface of differential pumping of the mass spectrometer, 22.4 hole in the wall between the second stage of the interface of differential pumping and Luggage mass analyzer, 22.5 - wall between the second stage of the interface of differential pumping and Luggage mass analyzer, a 23 - site orthogonal acceleration, 24 - cylindrical capacitor (reverse axially symmetric mass analyzer), 24.1 - input window circulating axially symmetric mass analyzer, 24.2 inner lining circulating axially symmetric mass analyzer, 24.3 external facing working axially symmetric mass analyzer, 24.4 - Central trajectory of the ions, 24.5 - output window circulating axially symmetric mass analyzer, 25 line inproved, 25.1 - screen linear inproved, 26 - ion detector, a 27 - rotary vane pump, 28, 29 - turbomolecular pumps, 30 - high-voltage modules 31 - controller, 32 - controller inlet of the ion gate or drive ions, 33 - controller heater, 34 controller prom ion shutter 35 - generator TTL pulses, 36 - host controller orthogonal acceleration 37 - integrating recorder. Figure 2 is a schematic representation of a device for analyzing fluid is x samples where 1 - electroepilation (in ON position), 1.1 - input channel capillary feed samples, 1.2 - needle electronicdevices, 1.3 - channel gas spray, 1.4 - channel high voltage supply, 2 - ionizer based on corona discharge (in OFF position), 3 - photoionization (in ON position), 4 - input device of the gas sample (in ON position), 5 - spray liquid samples (in OFF position), 6 - ionizer housing, 7 - camera inobtrusive, 8 - wall convex form, 9 - the hole at the top of the convexity of the wall, 10 - region desolvatation, 11 - ion inlet gate or hub, 12 - region drift, 13 - discharge ion gate, 14 - heater, 15 - channel pumping the drift gas and the sample, 16 - channel input of the cooled air to operate at a lower temperature or a rapid change in temperature mode, 17 - channel output of the cooled air, 18 - body mass spectrometer ion mobility, 19 - an analyte, 20 - gas region of the veil of the mass spectrometer, 20.1 - gas curtain used as the drift gas, 21 - the first step interface differential pumping of the mass spectrometer, 21.1 - hole of the first stage of the interface of differential pumping, 22 - second level interface of differential pumping, 22.1 - skimmer second stage of the interface of differential pumping, 22.2 - hole of the second stage of the interface of differential pumping, 22.3 - IO is owned by the optics of the second stage of the interface of differential pumping of the mass spectrometer, 23 site orthogonal acceleration 23.1 - eject the electrode 24 is a cylindrical capacitor (reverse axially symmetric mass analyzer), 24.1 - internal lining of a cylindrical capacitor, 24.2 - external facing cylindrical capacitor 25 line inproved, 25.1 - screen linear inproved, 26 - ion detector, a 27 - rotary vane pump, 28, 29 - turbomolecular pumps, 30 - high-voltage modules 31 - controller, 32 - controller inlet of the ion gate or drive ions, 33 - controller heater, 34 controller prom ion shutter, 35 - generator TTL pulses, 36 - host controller orthogonal acceleration, 37 - integrating recorder. Figure 3 is a schematic representation of a device using desorption of the substrate applied with the ionization-stimulated matrix laser desorption (MALDI), laser desorption from porous silica surface (DIOS), stimulated elektrorazpredelenie desorption (DESI shown in the drawing), where 1 - electroepilation (in ON position), 1.1 - input channel capillary feed samples, 1.2 - needle electronicdevices, 1.3 - channel gas spray, 1.4 - channel high voltage supply, 2 - ionizer based on corona discharge (in OFF position), 6 - ionizer housing, 7 - camera inobtrusive, 8 - wall convex form, 9 - hole on Erskine convexity wall, 10 - region desolvatation, 11 - ion inlet gate or hub, 12 - region drift, 13 - discharge ion gate, 14 - heater, 15 - channel pumping the drift gas and the sample, 16 - channel input of the cooled air to operate at a lower temperature or a rapid change in temperature, 17 - channel output of the cooled air, 18 - body mass spectrometer ion mobility, 19 - an analyte, 20 - gas region of the veil of the mass spectrometer, 20.1 - gas curtain used as the drift gas 21 - the first stage of the differential interface pumping of the mass spectrometer, 21.1 - hole of the first stage of the interface of differential pumping, 22 - second level interface of differential pumping, 22.1 - skimmer second stage of the interface of differential pumping, 22.2 - hole of the second stage of the interface of differential pumping, 22.3 ion optics of the second stage of the interface of differential pumping of the mass spectrometer, 23 - orthogonal accelerator, 23.1 - eject the electrode site orthogonal acceleration, 24 - circulating axially symmetric mass analyzer (cylindrical capacitor), 24.1 - internal lining of a cylindrical capacitor, 24.2 - external facing cylindrical capacitor 25 line inproved, 25.1 - screen linear inproved, 27 - rotary vane pump, 28, 29 - turbomolecular n is Sosa, 30 - high-voltage modules 31 - controller, 32 - controller inlet of the ion gate or drive ions, 33 - controller heater, 34 controller prom ion shutter 35 - generator TTL pulses, 36 - host controller orthogonal acceleration, 37 - integrating the recording device 38 desorber, 38.1 - desorption substrate, 38.2 - channel high voltage supply. The device operates as follows. When working with ionizer based on corona discharge 2 or photoionization 3 electronicdigital 1 disabled (Figure 1). An analyte 19 in the gas phase is fed through the input gas sample 4. An analyte 19 in the liquid phase is injected through an orthogonal set spray liquid samples 5. In the camera inobtrusive 7 at atmospheric pressure corona discharge or by photoionization generate ions, which through the opening 9 at the top of the convex wall 8 serves in the area desolvatation 10. Ions pass through the ion inlet gate or hub 11 and enter the drift region 12 at atmospheric pressure. In the drift region 12 is constantly serves the drift gas (high purity nitrogen or dry cleaned the air with a flow rate of 0.5-2 l/min), which as a gas curtain prevents the ingress of neutral particles in a mass spectrometer. The drift tube contains the desolvatation 10 and blast drift 12, separated inlet shutter or hub phase 11. Region desolvatation 10 drift and 12 in the radial direction is limited by a set of cylindrical electrodes forming an electric field. Driving under the influence of the electric field at atmospheric pressure ions of the analyte 19 collide with molecules of the drift gas. In the field desolvatation 10 is draining and deleteresource ions. The inlet shutter or hub phase 11 generates localized in space group containing ions of the analyte 19. This group, moving under the influence of an electric field in the drift region in a counter drift gas is divided into a series of groups containing components with different degree of retention of the molecules drift gas. Each of these groups reaches the outlet of the ion gate 13 during drift associated with the mobility component forming this group, and are directed into the gas curtain 20, which is exempt from neutral particles and gazodinamichesky concentrated on the hole 21.1 first-stage interface differential pumping 21. Through the hole 21.1 ions of the analyte 19 enter the first stage of the interface of differential pumping 21, providing an intermediate pressure between the pressure of the second stage and the atmospheric pressure is receiving the drift tube, where are concentrated on the hole 22.2 second stage interface differential pumping 22 skimore second stage interface differential pumping 22.1. Through the hole 22.2 sample ions enter the second stage of the interface of differential pumping 22, providing an intermediate pressure between the pressure of the first stage of the interface of differential pumping 21 and an operating pressure of the mass spectrometer. In the second stage of the interface of differential pumping 22 mass spectrometer ions are focused by ion optics 22.3 second stage interface differential pumping of 22 in a plane-parallel beam and concentrate on the hole 22.4 in the wall between the second stage interface differential pumping 22 and Luggage mass analyzer 22.5. After passing through the hole 22.4, ions in the form of a plane-parallel beam in the direction of axis Y in node orthogonal acceleration 23 of a cylindrical capacitor 24 in parallel to the symmetry axis of the mass analyzer Z. Moving parallel to the axis of symmetry analyzer Z ions fill site orthogonal acceleration 23. To eject the electrode site orthogonal acceleration 23.1 the host controller orthogonal acceleration 37 serves eject pulse, causing the ions to move perpendicular to its initial movement in the direction of the entrance window 24.1 reverse axiallysymmetric mass analyzer 24 along the y axis. The pushing pulse at the time the application locks the beam of ions from the interface and forms a short packet of ions as maintaining component of the velocity vxin the direction of the axis X, and the acquiring component of the velocity vyin the direction of the y-axis Moving in the Y axis direction, the beam through the input window 24.1 gets in the reverse axial-symmetric mass analyzer 24. Under the action of centripetal forces due to the axially symmetric field formed by the plates 24.2 and 24.3, ions acquire acceleration directed towards the axis of symmetry analyzer Z, and move in a spiral, moving around the circumference near the Central trajectory 24.4 and linearly along the z axis, the Ions leave the axially symmetric mass analyzer 24 through the output window 24.5 and fall in line inproved 25 protected screen 25.1. The potential of the screen line inproved 25.1 can be changed relative to the potential of the average path that allows you to change the length of the linear area needed to compensate for aberrations time-of-flight. The efficiency of the ions of the analyte regulate host orthogonal acceleration 23. Ions leaving the linear inproved 25, detects secondary electron multiplier 26. The signal of the multiplier register integrating recording device 37. Integrating zapisywa the developing unit 37 generates a signal, managing controller 36 site orthogonal acceleration 23. When working with electroepilation 1 (figure 2) ionizer based on corona discharge 2, photoionization 3, the input device of the gas samples 4 and the spray liquid samples 5 off (switched to the OFF position). An analyte 19 in the liquid phase is fed through a channel 1.1. For spraying, use a carrier gas supplied through the channel 1.3. The dispersion produced in the electric field generated between the needle 1.2 and a wall 8 having a convex shape. Born ions through the opening 9 at the top of the convex wall 8 coming into the region desolvatation 10, pass through the ion inlet gate or hub 11 and enter the drift region 12. When working with desorber 38 (Fig 3) an analyte is applied to the substrate 38.1, and desorption and the ionization is carried out by laser installed in place of electronicdevices 1 (methods MALDI and DIOS), or elektrorazpredelenie solvent by electroepilation 1 (method DESI). The 39 solvent in the liquid phase is fed through a channel 1.1. For spraying, use a carrier gas supplied through the channel 1.3. The dispersion produced in the electric field generated between the needle 1.2, the substrate 38.1 and a wall 8 having a convex shape. Between the substrate and 38.1 wall 8 put-off potential. Born ions through the opening 9 at the top of the convex is th wall 8 coming into the region desolvatation 10, pass through the ion inlet gate or hub 11 and enter the drift region 12. Write analytical signal are continuously. The specified number of time-of-flight spectra folded in accordance with the selected compression algorithm information. Received a one-dimensional array of transform data in a two-dimensional array. The received signal is a two-dimensional intensity distribution on the drift time and time-of-flight. For a fixed value of the time span of this distribution is transformed into a one-dimensional distribution of the drift time (selective for the mass chromatogram of the sample). For fixed values of the drift time this distribution is transformed into a one-dimensional distribution of the time-of-flight (TOF mass spectrum of the sample components corresponding to the selected time drift). The chromatogram transform in the distribution of a given mobility. Time-of-flight spectra are transformed in the mass spectra. Components identify the value of a given mobility and the mass corresponding to the maximum peak, and the amplitude or peak area to determine their concentration in the original sample analyte 19. Because the typical recording time range of masses (tens of microseconds) is much shorter than the characteristic time of recording the spectrum agility. the (tens of milliseconds), during the output of one of the components of the ion mobility spectrometer device manages to record multiple mass spectra. For each group divided by the mobility of ions recorded mass spectrum. The identification component to produce 3-dimensional information (see mobility, mass, intensity). Increased sensitivity is achieved due to the high tokophobia by focusing on three parameters. Spiral trajectory allows you to post the site orthogonal acceleration 23 and the ion detector 26 in different planes, which increases the efficiency of the analyte 19. Reduction of overall dimensions is achieved by movement of ions in a spiral in the cylindrical analyzer. 1. Mass spectrometer containing an ion mobility spectrometer, the ion-optical lens, the interface of differential pumping, time-of-flight analyzer and ion detector, wherein the ion mobility spectrometer includes a camera inobtrusive, drift tube with the aperture element, the ion gate, the drift region, the region of the gas curtain mass spectrometer, enter the drift gas, the power supply system, the ion source of the mass spectrometer includes a housing ionizer axially symmetric forms on the inside of the ionizer is installed radially directed the device in the ode and ionization of the sample analyte with ionizers, the point of intersection of the axes of the input device is positioned opposite the top of the aperture element made in the form of a wall of a convex shape with an opening for entry of ions at its peak and time-of-flight analyzer is made in the form of a cylindrical capacitor, in which the node is installed orthogonal acceleration eject the electrode and the ion detector. 2. Mass spectrometer according to claim 1, characterized in that between the cylindrical capacitor and the ion detector has a linear inproved. 3. Mass spectrometer according to claim 1, characterized in that the linear inprovide installed the screen with the possibility of changing its potential. 4. Mass spectrometer according to claim 1, characterized in that the input device and ionization of the sample analyte contain ionizers in the form of electronicdevices and/or ionizer by corona discharge, and/or photoinitiator, and/or a laser ionizer, and/or enter the spray of the liquid sample, and/or the input of gas samples, and/or substrates for desorption from the surface.
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