Sterilising system

FIELD: medicine.

SUBSTANCE: invention refers to sterilisation of various products. A sterilising system comprises a sterilisation chamber, connected with vacuum pump and evaporator with the evaporator accommodating a body, first path of a body to chamber outlet, second path of the body to chamber outlet and sterilisation controller. The first path of a body to chamber outlet is limited by a diffusion restraint and contains a first valve, and the second path of a body to chamber outlet contains a second valve used to connect the body to the sterilisation chamber for fluid motion without a diffusion barrier. The controller is programmed to perform the following process stages: connection of the evaporator and the sterilisation chamber via fluid through the diffusion restraint only, evaporation of a sterilising solution in the evaporator, closure of the first valve and decompression in the sterilisation chamber when evaporation is essentially completed.

EFFECT: invention allows reducing time for sterilisation cycle.

3 cl, 22 dwg, 2 tbl, 1 ex

 

The invention relates to the sterilization of products and, more specifically, to the sterilization of products, which includes the step of evaporation of the liquid chemical sterilizer.

Known implementation of sterilization of evaporated through a chemical sterilizer, such as hydrogen peroxide, peracetic acid and glutaraldehyde. In U.S. patent No. 6365102 included here by reference, describes a system of sterilization by hydrogen peroxide gas plasma containing a vacuum chamber, a source of steam, hydrogen peroxide and a source of high frequency to generate plasma. Such systems are sold under the name STERRAD from Advanced Sterilization Products division of Ethicon, Inc., Irvine, Calif.

According to U.S. patent No. 6325972 found that when the water has a higher vapor pressure than sterilizing component of the solution, such as hydrogen peroxide solution, by controlling the temperature and pressure at which the evaporation of the solution, it is preferable that the water could be removed from solution to increase the concentration of the sanitizer solution. If during the execution of this process, water is extracted from the system, the system remains sterilizer with high concentration. A higher concentration of the sterilizer during the stage in which the sterilizer is in the form of p the global phase is in contact with the sterilized products leads to increased efficiency of the sterilization process.

According to the published application number US 2003/0235511, was also identified efficiencies through the preferred condensation sterilizer to enhance the process of concentration.

The present invention provides an additional improvement of the system and method of sterilization according to US 2003/0235511 by increasing the speed at which it can be completed sterilization, especially sterilization of those products which have a cavity.

The method of sterilization of the product according to the present invention includes the steps are: set the message for fluid evaporator from the sterilization chamber through the diffusion constriction, while the sterilization chamber is at a lower pressure than the evaporator; evaporate the solution sterilizer, which contains the sterilizer and the solvent in the evaporator; after essentially complete evaporation of the sterilizer, compare the pressure in the sterilization chamber with a predetermined pressure and, if it exceeds the specified pressure, isolate the sterilization chamber from evaporation and reduce the pressure in the sterilization chamber to a pressure below a predetermined pressure; and then set the message for fluid evaporator with sterilization chamber and carry out the diffusion of the COI is represented sterilizer in the sterilization chamber and in contact with the product.

Preferably, the ratio of the sterilizer to the solvent in the evaporator increases by prevailing pumping the vapor phase of the solvent from the evaporator through the diffusion constriction and release at least part of the solvent from the sterilization chamber.

According to one aspect of the invention, after essentially complete evaporation of the sterilizer pressure in the sterilization chamber is compared with the second predetermined pressure and if the pressure in the sterilization chamber above, carry out a stop and notify the user. Preferably, the user optionally provides an indication to the effect that in the sterilization chamber with the product was filed, the excess water.

Preferably, the sterilizer is a peroxide, and the solvent is water.

In addition, preferably, when establishing message by fluid from the sterilization chamber to open the valve between the evaporator and the sterilization chamber.

Preferably, when establishing a message on fluid evaporator from the sterilization chamber through the diffusion gap between the evaporator and the sterilization chamber have the aperture.

Preferably, when the insulation of the evaporator from the sterilization chamber in the diaphragm miss clean the needle.

Water vapor mo is et to be evacuated from the sterilization chamber at low pressure in this chamber.

After evaporation of the sterilizer predominant amount of (and preferably all) amount sterilizer condense and then re-evaporated before the establishment of messages fluid evaporator with a sterilization chamber, in consequence of which will be provided for the removal of additional solvent.

According to another aspect of the invention, the method of sterilization of the product contains the stages, which provide the solution of the sterilizer, which contains the sterilizer and the solvent evaporated solution sterilizer in the evaporator; set the message for fluid evaporator from the sterilization chamber through the diffusion constriction, while the sterilization chamber is at a lower pressure than the evaporator; increase the ratio of the sterilizer to the solvent in the evaporator by the dominant pumping the vapor phase of the solvent from the evaporator through the diffusion constriction and release at least a portion of the solvent from the sterilization chamber with subsequent isolation of the evaporator from the sterilization chamber and reducing the pressure in the sterilization chamber to the set pressure is chosen so as to increase the diffusion of the evaporated sterilizer limited to diffusion zones of the product; and then set in an open message on fluid Ipari the El with the sterilization chamber and carry out the diffusion of the evaporated sterilizer in the sterilization chamber and into contact with the product.

The sterilization system according to the present invention contains the sterilization chamber, a vacuum pump connected to the sterilization chamber, and an evaporator connected to the sterilization chamber. The evaporator includes a housing, a first output path from the housing into the chamber, while the first way is limited by diffusion constriction, and the first valve in this path; a second output path from the housing into the chamber and a second valve in the second way, whereby the housing is communicated with the sterilization chamber for movement of the fluid without creating obstacles to the diffusion constriction. A controller to control the sterilization process, is programmed to provide the following process steps: messages fluid evaporator with a sterilization chamber only through the diffusion constriction; evaporation of a solution of the sterilizer in the evaporator; closing the first valve and reducing the pressure in the sterilization chamber when the evaporation is essentially completed.

Preferably, the diffusion constriction contained a plate made in her diaphragm. Preferably, the diameter of the aperture was between 1 mm and 3 mm

Figure 1 presents a block diagram of a sterilization system according to the present invention.

Figure 2 presents the block diagram of the evaporator and diffusion PU and sterilization system according to figure 1.

Figure 3 presents a block diagram of an alternative implementation of the sterilization system according to the present invention.

On figa presents a block diagram of an alternative implementation of the sterilization system according to the present invention.

On FIGU presents a view in section along line 3B-3B with figa.

4 shows a block diagram of an alternative implementation of the sterilization system according to the present invention.

Figure 5 presents a block diagram of an alternative implementation of the sterilization system according to the present invention.

Figure 6 presents a view in cross section on line 6-6 with 5.

Figure 7 presents a block diagram of an alternative implementation of the sterilization system according to the present invention.

On Fig presents a view in cross section on line 8-8 with Fig.7.

Figure 9 presents a block diagram of a sterilization system according to the present invention.

Figure 10 presents a view with a cutout of the output of the condenser/evaporator for use in a system according to Fig.9.

Figure 11 presents a view with a cutout input condenser/evaporator for use in a system according to Fig.9.

On Fig presents a perspective view of an alternative input condenser/evaporator for use in a system according to Fig.9.

The piano is g presents a perspective view with exploded parts of the condenser/evaporator according Fig.

On Fig presents a view in cross section along the line 14-14 with Fig.

On figa presents a view in cross section closeup of the valve block shown in Fig.

On Fig presents a perspective view with exploded parts of thermoelectric heating unit with pump and probes used in the condenser/evaporator according Fig.

On Fig presents an alternative sterilization system according to the present invention.

On Fig presents an alternative sterilization system according to the present invention.

On Fig presents an alternative sterilization system according to the present invention.

On Fig presents an alternative sterilization system according to the present invention.

On Fig presents a perspective view of an alternative input condenser/evaporator for use in a system according to Fig.9.

On Fig presents a manifold used in the input condenser/evaporator according Fig.

On Fig presents a view with a cutout valve block according pig, which is used in the input condenser/evaporator according Fig.

Figure 1 in the form of a flowchart presents the sterilization system 10 containing the sterilization chamber 12, an evaporator 14 and a vacuum pump 16. Vacuum pump capable of creating in the chamber vacuum, being the m preferably up to 0.5 Torr. Between the vacuum pump 16 and the chamber 12 is preferably a throttle valve 18 and, as a variant, the plate 20 with the diaphragm. Preferably, the throttle valve 18 also had good insulating ability. The pressure gauge 22, preferably located near the throttle valve 18 shows the vacuum in the chamber 12. The exhaust valve 23, which is used antimicrobial HEPA filter, provides a passage into the chamber 12 clean, sterile air. The evaporator 14 is connected to the chamber 12 through the elongated diffusion path 24. As shown in figure 2, the diffusion path 24 includes items 26 temperature control, designed to control the temperature in the diffusion path 24.

In this industry known evaporators suitable for evaporation of liquid sterilizer, such as a hydrogen peroxide solution. In U.S. patent No. 6106772 and in the application for U.S. patent No. 09/728973, filed December 10, 2000, which are incorporated here by reference, describes the vaporizers which are suitable for use in this patent application. In its simplest form, the evaporator may contain a small camera, which inject a liquid solution of hydrogen peroxide. Low pressure in the evaporator is provided by a vacuum in the chamber, causes the evaporation of the hydrogen peroxide solution.

Preferred is entrusted, to the evaporator 14 includes heating elements 28, which control the evaporator temperature to optimize the evaporation process. Preferably, where the evaporator 14 is connected with the diffusion path 24, in place of the section was provided with some form of insulation 30, so that the high temperature of the evaporator 14 had no harmful effect on the temperature of the diffusion path 24. The evaporator 14 and the diffusion path 24 preferably are made of aluminum; thermal insulation 30 may be in the form of compounds of polyvinyl chloride, connecting with each other these two elements.

In addition, it is preferable to include in the camera 12, the heater 32, preferably near the bottom of the camera 12, for re-evaporation of the condensed hydrogen peroxide inside the chamber 12.

The camera 12 preferably includes a mechanism (not shown) to create inside the plasma. Such a mechanism may include a source of radio-frequency or low-frequency energy, as described in U.S. patent No. 4643867 or in published patent application U.S. No. 2002/0068012, which are incorporated here by reference.

In the present invention, useful results are obtained by maintaining a certain amount of condensation of hydrogen peroxide, which evaporates from the solution in the evaporator 14, diffusion the m path 24. After evaporation of the greater part of the hydrogen peroxide solution elements 26 temperature control to increase the temperature of the diffusion path for re-evaporation of the condensed hydrogen peroxide. Water has a higher vapor pressure than the hydrogen peroxide, so the hydrogen peroxide vapor will condense more easily than water. Thus, the material which condenses on the diffusion path will have a higher concentration of hydrogen peroxide than the initial concentration of hydrogen peroxide solution in the evaporator 14.

The elements 26 of temperature control in their simplest form can be a heater, acting through electrical resistance. In this case, the low temperature environment of the diffusion path 24 provides a low temperature for condensation of the hydrogen peroxide, and control elements 26 further heat diffusion path 24 for re-evaporation now with a higher concentration of hydrogen peroxide of the diffusion path 24. As the temperature decreases, the vapor pressure of hydrogen peroxide falls, lower initial temperature on the diffusion path 24 provides a lower pressure in the chamber 12 without further prevent condensation of hydrogen peroxide on the diffusion path. Lower pressure what s in the chamber promotes the efficiency of the system, moreover, the elements 26 of temperature control may further comprise a cooling component for lowering the temperature of the diffusion path is lower than the temperature of the external environment. Acceptable cooling components include thermoelectric coolers or typical mechanical cooling system. In this case, the diffusion path 24 will first be cooled, preferably to about 10C., and then, some time after the start of the evaporation, or even after it is completed, the diffusion path 24 is preferably heated to 50C. or 110C.

If the diffusion path 24 is oriented vertically, as shown in figure 2, it has the potential to cause evaporation of the sterilizer for condensation in the cooler zones between the elements 26 of temperature control, and subsequent re-evaporation of the sterilizer when he passes the elements 26.

The next example shows useful results to control the heating of the diffusion path.

EXAMPLE 1

Tests were carried out on the efficiency through the location of the tray (3,51020), wrapped in CSR wrap and containing characteristic of the medical device and the subjects of the cavity, a 20-liter aluminum chamber (4,41222). In the center of each of the subjects of the cavities was placed odnogolosy stainless steel wire, monk is new, at least 1106disputes Basillus stearothermophilus. Were investigated the results in the case of temperature control of the diffusion path and without temperature control for cavity made of Teflon (polytetrafluoroethylene)having an inner diameter of about 1 mm and a length of 700 mm, and the cavity of stainless steel having an inner diameter of about 1 mm and a length of about 500 mm cavity with both ends were open. Each of samples was subjected to a sterilization cycle in a 20-liter vacuum chamber, which was maintained at 40C. and 3 Torr for 5 minutes. In the evaporator, which was kept at 60C, was injected under atmospheric pressure of 1.44 ml of 59% hydrogen peroxide solution in water. Then was the 5-minute countdown, and the pressure in the chamber was lowered to 3 Torr, which took less than one minute. In one case, the diffusion path 24 had an initial temperature of about 30C for the first minute, when it was pumped from the chamber to 3 Torr, after which it was heated to 50C for separation of condensed peroxide of the diffusion path in the camera for the rest of the cycle and continued pressure of about 3 Torr. In another case, during a cycle remained the temperature of the diffusion path of about 50C. Due to the preservation temperature diffusion path equal to 50C, diffusion path was withheld lisinoprilo the amount of peroxide, either she did not resist it. Sterilization efficiency was measured by incubating samples in the environment for growth at 55C and check the growth of the test organism. Table 1 presents the results of these test.

TABLE 1
Type cavityThe internal diameter and lengthThe path of diffusion at 50C throughout the processThe path of diffusion at 30C for one minute followed by an increase up to 50C
Teflon17002/20/3
Stainless steel15001/20/3

When the temperature of the diffusion path was kept high throughout the process, all of the samples in the test cavity Teflon were positive for bacterial growth, indicating poor outcome sterilization, one of the two samples in the test cavity stainless steel has also been positive. If the same conditions, but with the initially lower temperature is Ooty diffusion, which has been heated after one minute after the start of diffusion, none of the tested samples were not positive. Condensation peroxide on diffusion path during the initial stage of evaporation and subsequent re-evaporation of condensed peroxide of the diffusion path in the chamber significantly increases the efficiency.

Additional efficiency can be achieved by alternating cold and warm zones on the diffusion path 24, as generally represented in figure 2. The elements 26 of temperature control, in a simple form the heating elements are separated from each other. Also preferably, in this case, path 24 diffusion was vertical. When the hydrogen peroxide solution is evaporated and passes through the path 24 of diffusion, we can assume that he can turn to condense and re-vaporize as it passes over the heated and unheated sections 24 diffusion. Alternatively, the diffusion path can contain alternating heating and cooling elements.

The heater 32 in the chamber 12 acts like a heat path 24 diffusion. By controlling the temperature of the heater 32 can provide the initial condensation of hydrogen peroxide on the heater 32 and the subsequent re-evaporation in the chamber 12 to the concentration of peroxide.

The preferred cycle can represent the way the nd modification cycle, described in U.S. patent No. 6365102 included here by reference thereto. A number of pre-supplementation plasma energy with ventilation between them ensures the drying of moisture in the chamber 12. Then in the chamber 12 to create a vacuum and inject the hydrogen peroxide solution into the evaporator 14. Alternatively, the injection of peroxide can also be performed at atmospheric pressure. Some part of the evaporating solution condenses on the cold path 24 diffusion. After the passage of time, sufficient to ensure that all hydrogen peroxide solution or most of it has evaporated from the evaporator 14, the path 24 of the heat diffusion through elements 26 temperature control, and re-evaporation of the condensed hydrogen peroxide solution. About this time the throttle valve 18 is closed and switch off the pump 16 to seal the chamber 12. Thus, a significant part of the water fraction of the hydrogen peroxide solution is removed from the chamber 12 by the vacuum pump 16, and the remaining hydrogen peroxide solution, which re-evaporates from the path 24 of diffusion, or from the heater 32 in the chamber 12, if it is installed, will have a higher concentration of hydrogen peroxide than the original solution. Preferably, the control system is based on a computer (not shown) managed the process functions for the ease of you is filling up and the possibility of their repetition.

The thus created pairs of hydrogen peroxide comes in contact with the product 34 or articles 34 in the chamber 12, and carries out their sterilization. If these products 34 have a limited zone of diffusion, for example, a long and narrow cavity, it may be preferable subsequent ventilation of the chamber 12 and the better move vapor hydrogen peroxide clean and sterile air in the chamber to restricted diffusion zones. After that, the camera 12 is again exposed to vacuum and re-perform additional injection of hydrogen peroxide, preferably with consistent heating for diffusion path. Over a period of time sufficient for the sterilization of articles 34, preferably six-registration reduce infection by organisms such as Bacillus stearothermophilus, inside the chamber 12 has been provided with the illumination of the plasma, whereby was reinforced sterilization, and was provided with a breakdown of hydrogen peroxide into water and oxygen.

The plate 20 with the diaphragm may increase the effect of the concentration of hydrogen peroxide during its evaporation. As described in U.S. patent No. 5851485 included here by reference thereto, controlled or slow the pump down of the chamber 12 will initially result in removal from solution more water than hydrogen peroxide, since water has a b is more high vapor pressure, leaving the hydrogen peroxide with a higher concentration.

Management of pumping can be difficult, because the vacuum pumps typically do not provide a good enough back the throttle, and the throttle valves in the event of such applications are difficult to manage and it is expensive. By mounting the plate 20 with the aperture in the path of flow to the pump 16, the number of the atmosphere produced by the pump 16 from the chamber 12 will be limited, and by selecting the appropriate size of the aperture 36 in the plate 20 this number can be controlled to an extent that will effectively provided the concentration of hydrogen peroxide in the chamber 12.

If we turn to figure 3, there is shown therein a system 10A for the most part similar to the system 10 according to figure 1 and 2, while to the specified reference positions of such elements attached to the letter a, and this system also includes a plate 20A with the diaphragm. However, to ensure rapid evacuation of the chamber 12A with the preservation of useful results driven pumping provided by the plate 20A with the diaphragm, the system includes two ways of passing from the pump 16 to the chamber 12A. The first path 40 includes a throttle valve 42, and a second path 44 includes a throttle valve 46 and the plate 20A with the diaphragm. During the initial pumping opens first the th of the throttle valve 42, providing a loose coupling of pump 16A camera 12A. When the pressure in the chamber 12A approaches the vapor pressure of water, the first throttle valve 42 is closed, thereby forcing the pump 16A to perform a pumping through the plate 20A with the diaphragm and thus to empty the chamber 12A with less controlled rate that is more favorable to the prevailing remove water from a solution of hydrogen peroxide and from the chamber 12A.

If we turn to figa and 3B, it shows a system 110 that is similar to the system shown in figure 1. In this case, instead of using two paths, as in the system 10A according to figure 3, there is a valve 112, which includes a housing 114, the seat 116 and the valve element 118, for example, the rotary drive tube or something like that. In the valve element is made aperture 120. Thus, when the valve 112 is open, the pumping can occur quickly, and when the valve 112 is closed it will be slower. Such a valve may also be applied between the evaporator 14 and the chamber 12 to control the predominant evaporation and removal of water from a germicidal solution.

Now refer to figure 4, which, in addition to the use of high concentration of sterilizing steam to achieve efficiency and economy sterilization, also relates to the introduction of steam into contact with the sterilized product. Usually n is skoe pressure (0.5 to 10.0 Torr) in the chamber 12 facilitates the rapid diffusion of steam sterilizer in all areas.

4 shows a system 60 sterilization containing chamber 62 having an evaporator 64, the vacuum pump 66 and connected to the vent exit 68. Preferably, the elongated path 70 of diffusion with temperature control, which was previously described, connected to the evaporator 64 with the chamber 62. The pump 66 is installed throttle valve 72 and a pressure gauge 74.

Articles 76 to be sterilized are placed in trays or containers 78. When preparing products 76 for sterilization typically use two types of packages. In the case of one product 76 is placed in a tray with a large number of completed holes in it, after which the tray wrap material, such as CSR is a wrapper which passes sterilizing gases and blocks infecting microorganisms. A tray is described in U.S. patent No. 6379631 included here by reference thereto. Alternative packaging contains a sealed container with a few holes, preferably on its top and bottom surfaces, each of the holes is covered with a semi-permeable membrane, which is permeable sterilizing gases and blocks the penetration of contaminating microorganisms. Such container is described in U.S. patent No. 4704254 included here by reference thereto. The first type of package is usually called a tray, and the second container. However, the term is h "container", which is here used, refers to any container, packaging or shell, suitable for placement sterilized products in the environment, chemical vapors.

The pump 66 is connected to the chamber 62 through the exhaust manifold 80. The collector 80 includes one or more shelves 82, which serve for the installation and retention of one or more containers 78, and with passing of the fluid medium is connected to the pump 66 through the throttle valve 72. The hole or preferably a large number of holes 84 on the upper surfaces of the shelves 82 provide the possibility of pumping by the pump 66 of the atmosphere inside the chamber 62 through the holes 84, the collector 80 and out through the pump 66.

Containers 78 preferably have holes 86 on the lower surface 88 and additional holes 90, at least one other surface. If the containers 78 are located on the shelves 82, pumping the atmosphere produced by the pump 66, occurs partially through the holes 90 in the container 78 through the container from contact with the article or articles 76, and then through the holes 86 out into the reservoir 80 through made holes 84. When produced in this way, the atmosphere contains a sterilizing gas, will be reinforced its penetration into the containers 78 and entering into contact with the products 76.

STERI sousie gases are served in this way for the previously described cycle, when evaporating a solution of sanitizer and just before the second inlet hydrogen peroxide. This cycle can additionally provide pumping out after some period of diffusion. After submitting vapor sterilizer pressure in the chamber 62 increases slightly because of the presence of additional gas, usually about 0.5 Torr to 10 Torr. Elevated pressure effective at higher loads and temperatures in the chamber.

If we refer to figure 5 and 6, it is shown an alternative construction in which the reference positions of those elements that are similar to structural elements according to figure 4, added the letter b), in which the collector 80 of the construction according to figure 4 is replaced by a simple channel 92. The channel 92 is covered with a support 94 for a container 78, while bearing 94 has a large number of through holes 96 so that the camera 62b is in the status of the message, providing the movement of the fluid from the pump 66b through the container 78, the support 94 and the channel 92. Bearing 94 may be removable.

If you refer to Fig.7 and 8 (in which the reference positions of those elements that are similar to structural elements according to figure 4-6, added the letter C), it is shown bearing 100, located on the surface 102 in the chamber C, through which penetrates the channel s. Bearing 100 surrounds the channel s. Thus, most of atmosf the market or whole atmosphere, pumped by pump s passes through the container 78 in the space 104 formed between the container 78, the support 100 and the surface 102, and then to the pump is through the channel C.

Figure 9 shows an alternative system in which a similar system with 1 part evaporated germicidal solution may be condensed and the solvent, usually water, which is not condensed as quickly removed from the atmosphere for further concentration of the bactericide. After that, bactericide re-evaporated to obtain a more concentrated vapor bactericide for a more effective sterilization. The system contains the sterilization chamber 200, containing in itself the load 202 in the form of products to be sterilized. The source 204 of the solution of liquid bactericide provides feed solution through the valve 206 to the first evaporator/condenser 208, where it evaporates and then will be submitted to the camera 200. May be provided with a valve 210 to isolate the evaporator/condenser 208 from the camera 200. The camera 200 is also provided with valve output 212.

The vacuum pump 214 is used to lower the pressure in the chamber, as described with reference to the preceding embodiments of the design. Between the pump 214 and the camera 200 has a second evaporator/condenser 216 for condensing vaporized solution. Preferably, CL the lords 218 and 220 insulated second evaporator/condenser 216 from the pump 214 and the camera 200, respectively.

As shown in figure 10, a simple version of the second evaporator/condenser 216 preferably includes walls 222, forming a closed space 224, with supply 226, connected to the camera 200, and the outlet 228 connected to the pump 214. Many blades 230 creates a tortuous path 232 flow through the evaporator/condenser 216. The temperature of the walls 222 and potentially blades 230 can be controlled to enhance condensation and re-evaporation of the solution.

Similar design with a supply can also be applied in the first evaporator/condenser 208. Figure 11 shows a simple variant of the first embodiment of the condenser/evaporator 208. It includes a housing 240 having a supply 242, connected to a source of a solution of 204 (figure 11 are not shown), and the drain 244 connected to the camera 200 (figure 11 are not shown). Many blades 246 provides a tortuous path of flow through the first evaporator/condenser 208. The temperature of the housing 240 and potentially blades 246 can be controlled to enhance condensation and re-evaporation of the solution.

When a simple loop solution liquid bactericide, for example, consisting of hydrogen peroxide and water fed to the first evaporator/condenser 208, where it is vaporized and then passes into the chamber 200, which is at low pressure, this all happens as described will apply is Ino to the previous variants of implementation of the design. During evaporation, and some time after that, the pump 214 continues to pump out the atmosphere from the chamber 200. When the control of the temperature and pressure this allows the prevailing water evaporates over hydrogen peroxide, water vapor is removed from the system through the pump 214 to the concentration of hydrogen peroxide solution during the phase evaporation. In addition, hydrogen peroxide having a lower vapor pressure, will tend to more rapid condensation than water vapor in the first evaporator/condenser 208. When the pump 214 continues to pump out the atmosphere from the camera 200, the evaporated hydrogen peroxide solution flows out of the chamber and passes to the second evaporator/condenser 216, where part of it will be condensed. Due to the prevailing condensation of hydrogen peroxide to water a large part of the water vapor will pass through the capacitor 216 neskondensirovannyh and will be allocated via a pump 214, thus providing further concentration of the hydrogen peroxide solution. At some point the pump is switched off and the valve 218 is closed. After this is a re-evaporation of the condensed hydrogen peroxide inside of the evaporator/condenser 216 preferably by heating of the capacitor 216. The hydrogen peroxide will have a higher concentration is the Oia for a more effective sterilization load 202.

On Fig-15 presents a better condenser/evaporator 250. In General, it contains the intake manifold 252, which is connected to the source solution 204 sterilizer and provides initial evaporation, section 254 condensation/re-evaporation, the output manifold 256 and the control valve 258 through which the evaporator/condenser 250 is connected to the camera 200. The resistive heater 260 is fixed to the intake manifold 252 and to the exhaust manifold 256 to provide heating to facilitate the initial evaporation inside the intake manifold 252 and to prevent condensation in the exhaust manifold 256. Preferably, the inlet manifold 252 and exhaust manifold 256 were made of aluminum. In addition, between the inlet manifold 252 and section 254 of the evaporator/re-evaporator mounted insulator 262.

Section 254 of the evaporator/re-evaporator includes a housing 264, preferably made of aluminum, outdoor with the first side 266 and the second side 268. The first thermoelectric device 270 and the second thermoelectric device 272 are fixed respectively to the first side 266 and the second side 268. Thermoelectric devices 270 and 272 are preferably through the use of electrothermal Peltier effect, although they can be replaced thermoelectric devices on the natives classes. With some increase in complexity can also be used more conventional heat pumps, for example, systems based on freon or ammonia.

First whip the node 274 containing plate 276 and many pins 278, radiating along the normal, fixed to the first thermoelectric device 270, so that the pins 278 are held in the housing 264. The second pin node 280 similarly attached to the second thermoelectric device 272, so that its pins 278, addressed to the first pin node 274, pass into the housing 264. Whip nodes 274 and 280 are preferably made of aluminum.

Preferably, the pins 278 were almost to the opposite plate 276, not touching her. In addition, the pins 278 two pin nodes 274 and 280, in General, are parallel to each other with gaps between them, designed to work together with volume inside section 254 of the evaporator/re-evaporator to create a preferred flow rate of evaporated sterilizer through them to ensure efficient condensation on the pins 278. Preferably, the flow velocity was in the range of from 0.1 m/s to 5 m/s (0.03 to 0.15 m/s), and more preferably, the flow rate was 0.24 m/s (0,073 m/s).

In a small capacitor with the length of the path pair about 3 inches (76.2 mm) retention time will be availab who manage 1 second, with the preferred speed of the order of 0.24 ft/s (0,073 m/s). This retention time is sufficient for interaction evaporated sterilizer with the cooler surfaces of the condenser for condensation. For typical injection volume of about 2 ml sterilizer surface area 254 condensation/re-evaporation is approximately 90 square inches (0,058 m2for mass transfer with the aim of condensation. High temperature at low pressure in the primary evaporator (intake manifold 252) ensures the conservation of water and hydrogen peroxide in the vapor phase for the filing of a section 254 condensation/re. the evaporation. For example, the evaporator temperature of about 70C. or more under a pressure of about 125 Torr or below ensures that 59% of the weight of hydrogen peroxide solution and water will be in the vapor phase.

When steam enters the plot 254 condensation/re-evaporation, which has a lower temperature, the hydrogen peroxide condensed on the cooler surface, forming a concentrated solution. The temperature and pressure therein determine the concentration of the condensed solution. For example, at 50C and 13 Torr at site 254 condensation/re-evaporation, the concentration of the condensed hydrogen peroxide will be, by weight, 94%. At 30C and 3.8 Torr, the concentration of condensed re the IRS hydrogen will also be, by weight, 94%. When the pressure on the section 254 condensation/re-evaporation is reduced, the temperature must also decrease to maintain the same concentration of the solution.

Aperture 308 creates an advantage in obtaining a more concentrated solution by restricting flow from section 254 condensation/re-evaporation to provide a more controlled evaporation. Pressure changes at site 254 condensation/re-evaporation in the evaporator due to pressure fluctuations of the vacuum pump will be damped diaphragm 308 to prevent water vapour from drops, bearing hydrogen peroxide, from section 254 condensation/re-evaporation. Another advantage of restricting the flow through aperture 308 is to provide a low pressure (less than 1 Torr) in the sterilization chamber 200 to increase the diffusion coefficient in the cavity, while maintaining a higher pressure in the evaporator/condenser 250 for operation in higher temperature at site 254 condensation/re-evaporation. Without the aperture 308 of the pressure in the sterilization chamber 200 and the evaporator/condenser 250 should be jointly reduced to the same low value, and the capacitor must operate at a very low temperature to preserve the equilibrium solution. Than the others like the temperature of the condenser, the harder it is to manage, you can create ice or a capacitor, which requires more expensive design for protecting electrical equipment.

The o-ring 282 compacting plate 276 in thermoelectric devices 270 and 272 relative to the housing 264. Hole 284 passing through the housing 264, coincides with a hole 286 passing through the insulator 262, for the location of the camera 288 defined by the housing 264, so that it was reported to movement of fluid from the inlet manifold 252. The outlet channel 290 in the housing 264 is connected with the upper part of the chamber 288 and the second hole 292 passing through the insulator 262, which, in turn, coincides with the exhaust manifold 256 for camera message 288 with the exhaust manifold 256 for movement of fluid. Ensuring the safety thermostat 294 at the top of the housing 264 is connected by wires to the outer part of the control system to stop the heating of the evaporator/condenser 250 above a predetermined temperature. Temperature sensors 295 and 297 record temperature respectively in the inlet manifold 252 and section 254 of condensation/re-evaporation. The pressure sensor 296 is connected to the exhaust manifold 256. To each of thermoelectric devices 270 and 272 attach the heatsinks 298, having a housing part for the fan.

Issue the collector is connected to the valve manifold 300, which provides three possible ways to flow between the exhaust manifold 256 evaporator/condenser 250 and outlet 302 of the valve manifold 300. The exhaust valve 302 manifold communicates with the main camera 200. The main route 304 flow control through the valve 306, which can be opened to provide flow through the main channel 304 to the outlet valve 302 manifold, or closed to block such flow. The second path passes through the aperture 308 in the plate 310, which provides the restriction of the flow to increase the ability of the dominant pumping of water vapour from the evaporator/condenser 250. The third potential path passes through the rupture disk 312, which is designed to rupture in the event of a catastrophic overpressure inside the chamber 288, for example, in the unlikely event when oxidized sterilizer, such as hydrogen peroxide, lights up inside her. Aperture 308 may be moved in a certain position inside shut-off valve 306 similar to that described with reference to the valve element 118 with Figo and 3B.

When working initially producing pumping from the main chamber to a low pressure sufficient to initiate evaporation, for example, amounting to 0.4 Torr, and close the valve 306, providing a message evaporator/conten atora 250 camera 200 for movement of fluid only through the aperture 308. Intake manifold 252 is heated by the heater 260, and a certain number of solution sterilizer, for example, consisting of 59% hydrogen peroxide and water injected into the intake manifold 252, where it evaporates and diffuses to the housing 264 through holes 286 and 284. At this time, thermoelectric devices 270 and 272 are selected energy pins 278 and dissipate it through the heatsinks 298, thereby providing the possibility of re-condensation of the evaporated sterilizer on the pins 278.

The temperature of the intake manifold 252 can be controlled to slow the evaporation of the sterilizer, thus providing more rapid evaporation of water, the flow through the evaporator 250 and escaping through the aperture 308 in order to concentrate the remaining sterilizer. Section 254 of the condenser/re-evaporation is effectively concentrates the sterilizer, so to expedite the process can be done fast evaporation in the intake manifold, providing the high degree of concentration.

There is a tendency to a higher concentration of condensate on the pins 278 in the sterilizer. After some time, when the initial load solution sterilizer evaporated and part of it condensed on the pins 278, thermoelectric devices 270 and 272 connected to the application of heat to the pins 278 and re-evaporation CTE is ilitator. At this time, the heatsinks 298 still retain heat that is allocated during the execution of the previous stage, and this heat can be used in thermoelectric devices 270 and 272 for extremely efficient heating of the pins 278 and re-evaporation of the sterilizer. This incremental return effectively increases the energy of the device and allows a smaller and more compact capacitor 250 evaporation to provide the desired heating and cooling. After the sterilizer evaporated, the valve 306 is opened to perform effective diffusion vapor sterilizer in the main camera 200.

If you have applied the second evaporator/condenser 216, the design is preferably copied from the design of the evaporator/condenser 250, but without performing the intake manifold 252. In such a system after the initial diffusion in the main camera 200 pins inside of the second capacitor 216 will be chilled, and the pump 214 is enabled for the preferred removal of water vapor from condensing sterilizer. After a certain period of time, when the sterilizer is condensed, the pins will be heated to re-evaporation of the sterilizer, and the pump 214 is turned off. This re-evaporated sterilizer will have a slightly higher concentration and then re-diffuse into the chamber 200 for dalnas the th enhance the sterilization process.

There are other possible layout of the system. On Fig shows an alternative implementation of the design, which can improve the effectiveness of stabilization and concentration of the germicidal solution. In this system the camera 314 containing the load 316 has a first condenser/evaporator 318 connected to the source 320 a bactericidal solution, and the second condenser/evaporator 322. The first condenser/evaporator 318 isolated from the source 320 through the valve 323 and from chamber 314 through valve 324. He is also connected with the suction pump 325 and isolated from it by the valve 326. The second condenser/evaporator 322 is isolated from chamber 314 through the valve 327 and is connected to the pump 325, while it is isolated from it by valve 328. Also provided ventilation exit 329.

On Fig presents a similar system 330, which will be used for the condenser/evaporator 322 (having a construction similar to the construction of the condenser/evaporator 250 additional drain)connected to the sterilization chamber 334, designed to receive the load 336 in the form of instruments to be sterilized. Vacuum pump 338 is connected to the chamber 334 through the valve 340 and the condenser/evaporator 322 through the valve 342. Valves 340 and 342 may be replaced by the three-way valve. Source bactericidal solution 344 is outinen with condenser/evaporator 322, and the camera 334 has a ventilating aperture 346. During the initial evaporation and concentration of the bactericide from the source 344 valve 342 is closed. After the diffusion of steam into the chamber 334 valve 340 may be closed, and the pump 338 is used for pumping vapor from the chamber through the condenser/evaporator 322 in its mode of condensation for further concentration of the bactericide. Then concentrated biocide re-evaporates and is diffusion back into the chamber 334.

The second condenser/evaporator 216, shown in figure 9, can be used for maximum use of bactericide, when the sterilization process proceeds with two full cycles of pumping, injection, diffusion and release. Before the release during the first cycle, the pump 214 operates in conjunction with the condenser/evaporator 216 for condensation of bactericide. During the release process valves 220 and 218 are closed. During the subsequent pumping of the condenser/evaporator remain chilled to keep the bactericide from excessive evaporation and exit from the system.

The system according pig and 17 provides the ability to hold even more bactericide between cycles when executing a process with two cycles. Before the release in the first cycle involves condensation of the bactericide in the condenser/evaporator 322. However, during the last who tried pumping it can be isolated from the pump through the valve 342, thereby minimizing the tendency of the injection pump 338 saved the bactericide from the system during pumping.

In each of the systems of this type, the stage of condensation and concentration of evaporated bactericide, and subsequent re-evaporation, if necessary, may be repeated for additional concentration of the bactericide.

On Fig presents the system 350, arranged in an alternative way. In this system 350 condenser/evaporator 352 is connected through the valve 354 with the sterilization chamber 356 intended for location in her boot 358 and having a ventilating aperture 360. Vacuum pump 362 is connected to the condenser/evaporator 352 through the valve 364, but does not have a separate connection with the chamber 356. Source 366 bactericide is connected to the condenser/evaporator, 352.

On Fig presents the system 370, arranged as shown in Fig, and containing the condenser/evaporator 372, which is connected through the valve 374 with the sterilization chamber 376 intended for location in her boot 378 and having a ventilating aperture 380. Vacuum pump 382 is connected to the condenser/evaporator 372 through the valve 384, but does not have a separate connection with the chamber 376. Instead of supplying bactericide through the condenser/evaporator 372 source 386 bactericide solution is installed inside the chamber 376. The source of the IR can just imagine a tank, containing a certain quantity of a solution of liquid bactericide. Preferably, it was closed semi-permeable membrane or filter, so that the liquid bactericide could not be accidentally splashed out of him, but that when evaporation bactericidal at low pressure in the chamber created by the pair was able to pass through the membrane into the chamber. In both systems the condenser/evaporator 352 or 372 provides the concentration of the biocide through the condensation and re-evaporation vapor bactericide as described above.

On Fig presents another variant of implementation of the design input of the condenser/evaporator 400. It is mostly similar to that shown in Fig. However, as mainly shown in Fig and 22, it differs valve 402 aperture control. Valve unit 404 comprises an output control valve 406, the rupture disk 408 and the valve 402 aperture control.

On Fig shown separately valve block 404, it is shown that three of the collecting channel, which connects the valve unit 404 based condenser/evaporator 400: great collector channel 410 pressure relief, which leads to razryvnaya disk 408, a smaller upper manifold channel 412, which leads to the output control valve 406, and a lower side of the collector channel 414, which leads to the aperture 416 and to the valve 402 is driven by the I aperture.

On Fig presented in the best way valve 402 aperture control. Valve seat 418 on the valve block 404 surrounds the aperture 416. The valve element 420 on the valve 402 may pass to the saddle 418 for sealing with respect to it and block the movement of fluid through the aperture 416. Cleaning finger 422 enters the aperture 416, when the valve 402 is closed for cleaning aperture 416 and save it in a pure state without extraneous matter. The annular guide 424 connected to the valve element 420, slides inside the hole 426 in the valve block 404 for the appropriate matching of purification of the finger 422 aperture 416. This view also shows the valve seat 428 for the exhaust control valve 406 and the outlet channel 430 manifold, which leads to the sterilisation chamber (Fig-22 not shown).

The implementation of the sterilization cycle is almost the same as described above with reference to Fig-15. However, after the initial evaporation of the sterilizer in the intake manifold 252 (see Fig) valve 402 iris is closed, thus isolating the condenser/evaporator 400 from the sterilization chamber (Fig-22 not shown). This condition is the easiest to control by controlling the pressure inside the evaporator/condenser 400 assuming that when reaching particularly the th pressure essentially the entire sterilizer will be evaporated. Then the pressure in the sterilization chamber is reduced preferably about 0.5 Torr. This opens the exhaust control valve 406, and the pins 278 (see Fig) is heated to evaporate the condensed sterilizer and its passage through the exhaust control valve 406 and the outlet channel 430 to the sterilization chamber.

As installed, reducing the pressure in the sterilization chamber before serving mass sterilizer total cycle time can be reduced. The closing of the valve 402 aperture control and reducing the pressure in the sterilization chamber takes additional time. However, a lower pressure provides more favorable conditions for the diffusion of the sterilizer in a limited zone of diffusion, for example, the cavity of the instruments to be sterilized. It is established that the time saved through improved efficiency of diffusion, may be greater than the time interval required for lowering the pressure in the sterilization chamber. The speed of the sterilization cycle is an important factor for users sterilizer.

Water vapor in the sterilization chamber may influence the time required to reduce the pressure inside. This water vapor usually appears on the load in the form of instruments that have not been drained nadl the relevant way. If removal of water vapor requires excessive time, this may be an indication for the user that he was more vigilant regarding drying load during further cycles. Can be download from steam, in which case the execution of the removal or effective drainage can be quite long. In this case, the cycle must be canceled, and the user should be informed why this happened.

Table 2 presents the control values for the three different cycles - instant or very quick cycle in the absence of cavities, short cycle in the presence of such cavities, which are complex medium, and long cycle for sterilization devices with more complex, long and narrow cavities. During the initial evacuation to remove air from the sterilization chamber and the evaporator/condenser 400 exhaust control valve 406 is left open. When the pressure reaches the value P1, the exhaust control valve 406 is closed, while the valve 402 iris remains open, thus begins the evaporation and concentration of the sterilizer. Upon reaching values P2 inside the evaporator/condenser 400 check pressure PC within the chamber. If it is higher than the value presented in Table 2, klapa the 402 iris close and continue pumping until until it reaches the value of PC, then open the output control valve 406 to transfer sterilizer in the sterilization chamber. Otherwise, the output control valve 406 is opened immediately. If the pressure in the chamber exceeds the pressure PC of cancellation at the time when the pressure in the evaporator/condenser reaches a value P2, it is assumed that the sterilization chamber contains a lot of water and the cycle is canceled.

Table 2
Examples of reference values of temperature and pressure
InstantShortLong
Load statusSurface1 mm150 mm, stainless steel; 1 mm350 mm, plastic1 mm500 mm, stainless steel; 1 mm1000 mm, plastic
The evaporator temperature70C70C70C
The temperature of the condenser58C52C43C
P1, the pressure of the evaporator/condenser to remove air140 Torr140 Torr140 Torr
P2, the pressure of the evaporator/condenser for concentrating sterilizer22 Torr16 Torr10 Torr
RS, the pressure in the chamber to select transfer, then create a vacuum or cancelof 1.5 Torrof 0.6 Torrof 0.3 Torr
RS-cancellation, the pressure in the chamber to cancel cycle8 Torr6 Torr4 Torr
The temperature of the condenser for transferring concentrated sterilizer68C68C68C

The invention is described with references to preferred options for its implementation. Obviously, after reading and understanding the preceding detailed description, it will be possible to perform additional options and changes. It is assumed that the invention be construed as including all such variations and changes in the article is fine, in which they are included in the scope of the attached claims and their equivalents.

1. The sterilization system that contains
the sterilization chamber;
a vacuum pump connected to the sterilization chamber;
the evaporator is connected to the sterilization chamber, the evaporator contains
case;
the first output path from the housing into the chamber, and the first output path is limited by diffusion constriction, and the first valve in the first path output;
a second output path from the housing into the chamber and a second valve in the second way, whereby the housing is communicated with the sterilization chamber for movement of the fluid without creating obstacles to the diffusion constriction;
a controller to control the sterilization process, the controller programmed to provide the following stage of the process:
message in a fluid environment of the evaporator with the sterilization chamber only through the diffusion constriction;
evaporation of the solution sterilizer in the evaporator;
closing the first valve and reducing the pressure inside the sterilization chamber, when the evaporation is essentially completed.

2. The sterilization system according to claim 1, in which the diffusion constriction includes a plate with an aperture in it.

3. The sterilization system according to claim 2, in which the diameter of the aperture is between 1 mm and 3 mm



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention refers to sterilisation equipment and can be used in small clinics and laboratories. A sterilisation package (1) contains a sterilisation unit (2) and treatment tool (3) managing the sterilisation process performed in said sterilisation unit (2). The unit (2) and tool (3) are mechanically partitioned from each other, however interlocked by input-output unit (4) and/or environment exchange device (5). In addition the sterilisation package comprises an outer case (7). Said sterilisation unit is equipped with supplied by a door (8) when open being in-between a sterilisation chamber (6) wall and the outer case (7), therefore the door (8) surfaces are user-unavailable.

EFFECT: invention enables to design said sterilisation package easy to manufacture and handle.

11 cl, 3 dwg

FIELD: construction.

SUBSTANCE: bactericide unit is designed for water disinfection on underwater manned vehicles. The bactericide unit comprises a U-shaped housing separated into compartments and containing a filtering element, UV lamp, connecting manifold, partition with angular through holes and individual control panel connected via electric cable to the UV lamp, and the UV lamp and filtering element are located in the side compartments of the U-shaped housing. The connecting manifold is made of two pipes joined at an angle 30° to 120°, and a dead pocket fitted with an absorbing insert is connected to one of the pipes in axial alignment with the UV lamp. Inside the connecting manifold, a partition with through holes is located, with the holes made in the form of noncircular channels with light-reflective surfaces. The control panel is equipped with a power supply unit, symbol display annunciator, electronic starting and control unit for UV lamp lighting, and a microcontroller-based control board, which provides galvanic power isolation, input and output signals.

EFFECT: improved water treatment quality and equipment reliability together with serviceability and reduced equipment dimensions and weight.

2 cl, 6 dwg

FIELD: medical engineering.

SUBSTANCE: installation has functional units having maintenance means. It has the laboratory unit proper and storage unit. The proper laboratory unit is divided into two compartments. Frontal compartment serves as auxiliary compartment and the back one serves as assistant aseptic compartment. The proper laboratory unit as a whole comprises functional equipment and maintenance means. An auxiliary compartment of the proper laboratory unit has treated water collector, injection water collector, plant for producing injection water from natural spring water under field conditions, drying box, compressor system, bactericide irradiator, vapor-type sterilizer, arranged along its perimeter. The plant for producing injection water from natural spring water under field conditions comprises precleaning filter, feeding pump, coarse filter, ultrafiltration means, high pressure pump, reverse-osmosis filter, specific electric resistance measurement means, carbon filter, cation-exchange filter, anion-exchange filter, the second specific electric resistance measurement means and cartridge filter for sterilizing by filtering. The reverse-osmosis filter is additionally attached to discharge line. The anion-exchange filter has additional outlet to the treated water collector. The cartridge filter for sterilizing by filtering has additional outlet to the injection water collector. The installation has treated water recirculation option. Complex for producing infusion solutions is mounted in assistant aseptic proper laboratory unit in polymer containers. It comprises system for preparing solution and its sterilizing filtration, aseptic dosing system for filling sterile polymer containers provided with filling needles, and power support unit, unit for controlling infusion solutions quality. The complex for producing infusion solutions in polymer containers has reactor, peristaltic pump, solution filter holder having membrane, connection tube set, dosing and filling device having sphincter valve, air filter holder and micro-box, power supply source, compressor unit. Means for maintaining both units have electrical equipment, illumination, heating and forced ventilation, water supply, internal and external communication systems. Water which quality is not to be higher than that of natural springs is useable in production process raw material.

EFFECT: simplified design.

20 cl, 2 dwg

FIELD: pharmaceutical industry, in particular, equipment used in pharmacies, medical field enterprises, may be part of complex technical medicinal service means.

SUBSTANCE: complex has basic members and units such as reactor, peristaltic pump, filter holder with membrane for solution, connection pipes (set), dosing-pouring device with pinching valve, air filter holder, power unit, compressor unit, compressed gas balloon (for creating excessive pressure in reactor in case of lack of electric energy), compressed air balloon (for supplying air into aseptic dosed pouring unit in case of lack of electric energy).

EFFECT: light-weight construction of complex allowing infusion solutions to be produced and doses of ready solution to be poured into polymeric containers under aseptic conditions.

5 cl, 3 dwg

The invention relates to the field of pharmacy and can be used in medical institutions, pharmacies, pharmaceutical laboratories, and other areas associated with the use of sterile solutions of drugs (RLS)

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to a syringe, particularly to a syringe designed as pre-filled and thereafter steam-sterilised in an autoclave, and also to a kit containing a package and said syringe in presented package. The syringe comprises a body, a rod, an internal chamber and carrier. The body has a cylindrical lateral wall and an open upper downstream end with an internal ring collar nearby, and lower downstream end closed with a transverse apertured wall. The rod forms a plunger arranged on the same end with a piston that forms a seal and has at least two sealing rings that fix the borders of at least one annular chamber. The rod is introduced inside of the body while travelling there along. The internal chamber is designed to be filled at least partially. The borders of the chamber borders are limited by the piston and a crosswall of the body. Carrier is formed in the body of the syringe and ensures communication of the annular chamber, or the piston chambers with area outside of the body, or with the internal chamber of the body as the piston is inside of the body and adjoins the ring collar. The kit comprises actually microorganism-impermeable at least partially steam permeable package and said syringe. And said syringe is enclosed in said package, and its internal chamber is filled with contents at least partially.

EFFECT: invention allows for damp heat sterilisation of areas between rings of the syringe piston and as a result considerably reduces amount of heat required for sterilisation.

8 cl, 7 dwg

FIELD: medicine, surgery.

SUBSTANCE: invention can be applied to septic wounds, cavities, and fistulas sanitation. The means comprise aqueous antiseptic solution, including 2.7-3.3% hydrogen peroxide, 0.9-10.0% sodium chloride, and carbon dioxide giving positive pressure 0.2 atm at +8°C.

EFFECT: invention provides safe and effective sanitation conditions, facilitates biological masses elimination, renders expressed geyser-like, dehydrating and antiseptic action.

1 ex

FIELD: technological processes.

SUBSTANCE: device is intended for sterilisation of packages with gaseous sterilising agent during whole process of sterilisation. At that mentioned device contains heating zone, sterilisation zone and zone of ventilation. At that device additionally contains detector of environment temperature for determination of environment temperature outside the device. Device also contains meter of concentration for measurement of sterilising agent concentration in the zone of sterilisation. Besides, device contains the first control unit for regulation of sterilising agent amount, which is supplied to zone of sterilisation. At that control unit supplies sterilising agent on the basis of measurements, which are obtained from the environment temperature detector and from concentration meter. Declared invention is also related to the method of packages sterilisation.

EFFECT: group of inventions provides more reliable method of sterilisation; improved control of gas flows in different zones and between them and improved control of packages heating.

54 cl, 2 dwg

FIELD: food engineering, in particular, equipment for sterilization of beverage containers by exposing said containers to flow of air and hydrogen peroxide vapor mixture.

SUBSTANCE: sterilization apparatus has H2O2 evaporator comprising air-washed evaporation chamber equipped with heated walls which are sprayed by means of nozzle device with hydrogen peroxide. Nozzle device comprises only one air nozzle designed for tangential blowing of narrow air flow into chamber and only one nozzle for hydrogen peroxide designed for generation of continuous liquid flow having diameter of about a number of decimals of millimeter. Nozzle for hydrogen peroxide is positioned within body for generation of liquid flow in direction transverse to air flow course and in spaced relation thereto.

EFFECT: increased efficiency by avoiding loading of apparatus channels.

3 cl, 2 dwg

FIELD: medical engineering.

SUBSTANCE: device has casing 1, door 2, power frame 11 of the door, locking bracket 3 and mechanism for blocking the locking bracket 5 doors mounted on opposite axles of forcing frame axles rotatable about vertical chamber axis, and mechanism for locking and fixing the door 4 mounted on in the central locking bracket part. Destructor set is mounted on casing back wall and inlet and outlet nipples. The mechanism for blocking and locking door 4 is designed as three-cam handle fastened in case-shaped bushing conjugated with lead screw. Hemispheric lead screw end is placed into matching hemispheric recess of door-fastening member. The mechanism 5 for blocking locking bracket 3 is designed as rotating threaded upright mounted on forcing frame axle.

EFFECT: high reliability in sealing sterilization chamber; prolonged service life; high operation reliability and safety level.

5 cl, 7 dwg

FIELD: sterilization and transportation of small-size light-weight objects such as bottle plugs, possibly in food making, biotechnology, pharmaceutical industry branch.

SUBSTANCE: method for sterilizing small-size objects by means of ozone-air mixture for further neutralizing ozone by its natural dissociation in air in the same closed gas circuits having unit for cleaning and drying air, compressor, ozone-air mixture generator and sterilizing chamber. Objects are transported from sterilization chamber along other closed gas circuit that also includes discharging cyclone and sterilized-air compressor. Continuous process is realized due to using two or more sterilizing chambers taking part in operation of said gas circuits in automatic mode according to cyclic diagram of process parameters.

EFFECT: possibility for performing continuous process of sterilizing and transporting objects with use of ozone and compressed air in extensive rational technological cycle while eliminating influence of ozone upon air on working zone.

4 cl, 3 dwg

FIELD: disinfection and sterilization of medical designation objects such as complex-shape tools for surgery, stomatology, tubular members and articles such as endoscopes, laparoscopes, catheters and so on objects including thermolabile articles.

SUBSTANCE: apparatus for disinfecting and sterilizing includes chamber whose inner surface reflects UV -irradiation; pulse UV-lamps arranged inside chamber in quartz tubes by rows (at least two lamps in each row); latticed trays for treated objects; electric power source connected through high-voltage conductors with pulse UV-lamps; automatic control unit made with possibility for setting repetition frequency of high-voltage pulses of power source; device for spraying antiseptic matter. Said device is communicated through pipelines with antiseptic matter sprayers mounted on inner surface of chamber in such a way that aerosol provided by them in chamber may perform vortex motions. Sterilized ozonated air created by cooling of pulse lamps is fed inside working chamber. Biologically active aerosol-gas mixture generated at sterilization process is pumped through inner cavities of treated object.

EFFECT: shortened time period for sterilizing and disinfecting, possibility for treating complex-shape objects with deep cavities and tubular objects.

4 cl, 1 dwg

FIELD: medicine.

SUBSTANCE: method involves taking things under disinfection into chamber, sealing the chamber, filling it with ozone and making ozone-air mixture circulate. The chamber is degassed after having finished disinfection and the things are unloaded. The chamber is filled and things are kept in the chamber with normal climatic environment factors being supported in the chamber. When filling the chamber with ozone, air rarefaction is created in the chamber and supported until ozone concentration in the chamber reaches 2g/m3. Then, ozone-air mixture circulation is supported and the things under disinfection are hold under ozone action within 2-6 h when the chamber is loaded with 40 to 120 kg per 10 m3, respectively.

EFFECT: enhanced effectiveness of disinfection.

27 cl, 9 dwg, 2 tbl

FIELD: sterilization facilities.

SUBSTANCE: inflammable gaseous compositions contain 1.7-11 wt % ethylene oxide and 98.3-89 wt % flame suppressor including pentaflouroethane, and heptafluoropropane. Such compositions are suited to perform gas sterilization of heating and humidity sensitive materials and can be used with low-pressure bottles.

EFFECT: increased efficiency and handling safety.

12 cl, 6 ex

The invention relates to a method of sterilization with gaseous hydrogen peroxide medical products, such as injectable kit, filled with medicine and enclosed in the packing container

FIELD: sterilization facilities.

SUBSTANCE: inflammable gaseous compositions contain 1.7-11 wt % ethylene oxide and 98.3-89 wt % flame suppressor including pentaflouroethane, and heptafluoropropane. Such compositions are suited to perform gas sterilization of heating and humidity sensitive materials and can be used with low-pressure bottles.

EFFECT: increased efficiency and handling safety.

12 cl, 6 ex

FIELD: medicine.

SUBSTANCE: method involves taking things under disinfection into chamber, sealing the chamber, filling it with ozone and making ozone-air mixture circulate. The chamber is degassed after having finished disinfection and the things are unloaded. The chamber is filled and things are kept in the chamber with normal climatic environment factors being supported in the chamber. When filling the chamber with ozone, air rarefaction is created in the chamber and supported until ozone concentration in the chamber reaches 2g/m3. Then, ozone-air mixture circulation is supported and the things under disinfection are hold under ozone action within 2-6 h when the chamber is loaded with 40 to 120 kg per 10 m3, respectively.

EFFECT: enhanced effectiveness of disinfection.

27 cl, 9 dwg, 2 tbl

FIELD: disinfection and sterilization of medical designation objects such as complex-shape tools for surgery, stomatology, tubular members and articles such as endoscopes, laparoscopes, catheters and so on objects including thermolabile articles.

SUBSTANCE: apparatus for disinfecting and sterilizing includes chamber whose inner surface reflects UV -irradiation; pulse UV-lamps arranged inside chamber in quartz tubes by rows (at least two lamps in each row); latticed trays for treated objects; electric power source connected through high-voltage conductors with pulse UV-lamps; automatic control unit made with possibility for setting repetition frequency of high-voltage pulses of power source; device for spraying antiseptic matter. Said device is communicated through pipelines with antiseptic matter sprayers mounted on inner surface of chamber in such a way that aerosol provided by them in chamber may perform vortex motions. Sterilized ozonated air created by cooling of pulse lamps is fed inside working chamber. Biologically active aerosol-gas mixture generated at sterilization process is pumped through inner cavities of treated object.

EFFECT: shortened time period for sterilizing and disinfecting, possibility for treating complex-shape objects with deep cavities and tubular objects.

4 cl, 1 dwg

FIELD: sterilization and transportation of small-size light-weight objects such as bottle plugs, possibly in food making, biotechnology, pharmaceutical industry branch.

SUBSTANCE: method for sterilizing small-size objects by means of ozone-air mixture for further neutralizing ozone by its natural dissociation in air in the same closed gas circuits having unit for cleaning and drying air, compressor, ozone-air mixture generator and sterilizing chamber. Objects are transported from sterilization chamber along other closed gas circuit that also includes discharging cyclone and sterilized-air compressor. Continuous process is realized due to using two or more sterilizing chambers taking part in operation of said gas circuits in automatic mode according to cyclic diagram of process parameters.

EFFECT: possibility for performing continuous process of sterilizing and transporting objects with use of ozone and compressed air in extensive rational technological cycle while eliminating influence of ozone upon air on working zone.

4 cl, 3 dwg

FIELD: medical engineering.

SUBSTANCE: device has casing 1, door 2, power frame 11 of the door, locking bracket 3 and mechanism for blocking the locking bracket 5 doors mounted on opposite axles of forcing frame axles rotatable about vertical chamber axis, and mechanism for locking and fixing the door 4 mounted on in the central locking bracket part. Destructor set is mounted on casing back wall and inlet and outlet nipples. The mechanism for blocking and locking door 4 is designed as three-cam handle fastened in case-shaped bushing conjugated with lead screw. Hemispheric lead screw end is placed into matching hemispheric recess of door-fastening member. The mechanism 5 for blocking locking bracket 3 is designed as rotating threaded upright mounted on forcing frame axle.

EFFECT: high reliability in sealing sterilization chamber; prolonged service life; high operation reliability and safety level.

5 cl, 7 dwg

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