Deposition of antimicrobial agent on elastomeric product

FIELD: chemistry.

SUBSTANCE: elastometic products have low microbial affinity. The product has a substrate body partially moulded from natural or synthetic polymer latex having an antimicrobial composition from antimicrobial substance, tightly joined to the first surface of the said substrate, forming a uniform non-volatile antimicrobial coating on at least a region of the said first surface. When testing the product there is no loss of antimicrobial molecules from the said first surface in dry leaching testing conditions, in wet leaching conditions or both tests on the inhibition zone. The elastomeric product is characterised by fall in relative concentration of microbes on the said first surface by a value of at least log10 1 within a period of about 6 minutes.

EFFECT: increased duration of the protective effect and restricted transfer of microbes from the surface of the product to surrounding surfaces.

26 cl, 1 dwg, 8 tbl

 

The scope of the invention

The present invention relates to elastomeric products which are not leachable antimicrobial agent is deposited on their surface and stably associated with them.

The level of technology

Many elastomeric products traditionally made from natural and synthetic polymeric materials such as polyisoprene, nitrile rubber, vinyl (PVC), polychloroprene or polyurethane materials, partly due to its excellent elasticity, processability and physical properties after crosslinking of these materials. Elastomeric products can be adapted for various kinds of applications, such as clinical, laboratory or medical purpose, or in manufacturing and other industrial uses. The ability of the elastomeric product to deform and recover essentially its original shape when released after being stretched to many times its original length, is an advantage. In addition to having high elasticity, natural rubber and synthetic mesh also provide good strength and good barrier properties that are attractive and important features. Good barrier properties, thanks to which products can be made impervious not the only for aqueous solutions, but also for many solvents and oils, can provide effective protection of the user's body from the environment, successfully protecting both parties from mutual contamination.

Because the requirements of a good barrier control increase and spread to many areas of everyday life, the use of products made from elastomeric materials, similar to growing and expanding. For example, in the field of medical and surgical products, including surgical, test or work gloves, spill prevention, condoms, catheters, balloons, pipe or other device, and the like, which can be used in biological, chemical, or pharmaceutical research and laboratory, clinical or diagnostic appointments, maintaining good barrier protection was important. The basic principles put forward by the Centers for disease control (CDC), encourages the use of universal precautions in all cases, work with biological or chemical samples for testing or in contact with patients and make products latex work gloves or test standard practice, as they directly contribute to the reduction of pollution.

However, the elastomeric articles, such as gloves, condotelware microbial problems, controlling them can be difficult. To control microbial contamination elastomeric surfaces in the past, the traditional practice was required to use a disinfecting means and/or disinfectants, such as ammonia, chlorine or alcohol. These methods tend to work for short periods of time and often do not have long-term protective effect to prevent the transfer of germs on the surface or to stop it.

Gloves have been designed to limit the transfer of germs from the surface of the gloves of the surrounding surface. This usually happens when using the so-called leachable antimicrobial compositions on the surface of the gloves. In this approach, the concentration of the antimicrobial compositions on the surface of the gloves is gradually reduced as the bacteria absorb antimicrobial compounds that continue to kill them. Further, when the concentration of leached, the effectiveness of the antimicrobial agent on the glove is reduced. In addition, in recent years, concern about the biological stability and the development of so-called resistant to antibiotics, strains of bacteria have forced people in the community medicine and health to abandon the use of gloves with leachable antimicrobial to the positions.

As an alternative, researchers are turning to methods of application of non-leachable antimicrobial compositions on the surfaces of gloves and other elastomeric products. The production of elastomer products, which are not leachable antimicrobial agents on their surfaces, in General is not particularly successful. Requires an understanding of surface chemistry and various other parameters, and the force or the task of developing a process that can stably associate an antimicrobial agent to the surface of elastomer products, are not easy or trivial. Therefore, there is a great need to develop a system or method that can detect not leachable antimicrobial elastomeric composition on the substrate while maintaining a consistent and effective antimicrobial action.

Summary of invention

Due to the existing need in elastomeric products that are consistently associated with non-leachable antimicrobial coatings, the present invention is due in part to a method for producing an elastomeric product having an antimicrobial coating on at least the area of the outer surface. This method includes providing the substrate or element made from either natural or with staticheskogo polymer latex, moreover, this substrate is different in that it has first and second surfaces, obtaining or providing antimicrobial solution containing protivovspenivayushchie agent, which is heated to a temperature of from about 40.5°C or 43°C (105°F or 110°F) to about 80°C (180°F), preferably from about 48°C or 50 to 75°C. or, more preferably, about 55-72°C; supply device coating spray, with at least spray nozzle, or baths of the antimicrobial solution; applying the heated antimicrobial solution is either a) through the spray nozzle at a pressure air supply of about 30-50 pounds per square inch (206,84 kPa - 344,74 kPa) and a flow of fluid from about 1.25 to 5.5 pounds per square inch (8,62 kPa - 37,92 kPa) on the first surface of the substrate during processing of the substrate in a heated rotating the camera, or by b) immersion in a hot tub, where it is stirred or crumple. In each repetition, or spraying, or coating in the bath elastomer product process for the efficient amount of time to essentially bind antimicrobial coating with the substrate. An effective amount of time, as shown here, refers to a sufficient interval that will create long-lasting and not leached attaching or linking antimicrobial molecules with the surface is hnestly elastomeric products. This duration may be in the range from several minutes (e.g., 5-30 minutes) to about 1-2 hours, depending on the specific conditions.

The present invention, in another object, and also relates to an elastomeric product or a product manufactured by the described method. Elastomeric product contains a first surface having stably associated, not leachable antimicrobial coating on at least a part of the first surface. This antimicrobial coating does not feel leaching or loss of antimicrobial molecules covered with the first surface when it is exposed to a test mode, comprising the first option or the second option, or both tests the zone of inhibition. That is, the elastomeric product does not produce zones of inhibition when it is subjected to the first and second variants of the test zone of inhibition.

In the first embodiment, indicated here as a test of dry leaching Protocol established by the American Association of textile chemists and colorists (AATS), a known concentration of microorganisms on the surface of agar plates showed no inhibition of growth or existence, when a portion of the substrate treated with an antimicrobial substance, is placed on the agar plate and incubated. No areas in which euromania indicates no antimicrobial agent is not leached or becomes associated with the surface of the processed substrate. The second option, specified as the wet test leaching or dynamic shake flask Protocol established by the American society for testing and materials (ASTM), the supernatant solution, in which a portion of the substrate treated with an antimicrobial substance was incubated, put on the agar plate with a known number of microbes on the surface of the plate and agar plate shows no zone of inhibition; therefore, showing that the antimicrobial agent associated with the processed substrate, by being attached to the substrate, and it is not leached in the supernatant solution.

Elastomeric products covered non-volatile antimicrobial layer, can demonstrate the level of biocidal efficiency, which reduces the concentration of microbes on the first surface by an amount at least log101, when they are subjected to the test Protocol contact transfer.

Additional characteristics and advantages of the present protective elastomeric products and related manufacturing methods are disclosed in the following detailed description. It is clear that as predshestvuyuschee content, and the subsequent detailed description and examples are simply a variant of the invention and are intended to provide a brief overview for the understanding of the invention as it is claimed.

Brief description of drawings

The drawing shows an elastomeric article, namely a glove 10, which can be obtained according to the present invention having the surface 12 of the substrate with stably associated, non-volatile antimicrobial coating 14.

Detailed description of the invention

Section I - definitions

In this description and appended claims forms singular indefinite and definite articles include many references unless the context clearly dictates otherwise. If not stated otherwise, all technical and scientific terms used herein have the same meaning as they usually know or usually are experts in this field, which is the addressee of the invention.

As is used herein, "antimicrobial" refers to the connection property, product, composition, or product, which enables him to prevent or reduce the growth, expansion, extension, or other activity of the microbe or culture of a microbe.

As used here, "antimicrobial polymer layer" refers to a coating, film or processing of generated IP is by the use of the antimicrobial composition or agent, as defined and described herein.

As used here, "elastic or elastomeric refers to the capability of the material to be stretchable in at least 10% (i.e., the material may be stretched to at least 110% of the original size), and is able to shrink and return to close to them or the original size.

As is used herein, "microbe" or "microorganism" refers to any organism or combination of organisms, likely capable of causing infection or pathogenesis, such as bacteria, viruses, simplest, yeast, fungus or mold.

As used here, not "leach" or "non-volatile" refers to the capability of the material to be essentially attached to the surface of the substrate, which is applied to the material, and to give the material a small probability or complete lack of ability to spontaneous moving, splitting, slicing or to be removed or separated from the surface. Not leachable antimicrobial coating may be further defined in relation to a particular contact record based on agar and testing with dynamic shake flask as defined in the test report AATS-147 or the test report ASTM E-2149-01, in which the substrate with an antimicrobial coating does not form a zone of inhibition, indicating that the while what antimicrobial agent is not separated from the substrate to inhibit the activity or growth of microbes. "Substantial coverage" refers to the non-volatile coating, which is a coating that is essentially attached to the surface of the elastomeric product.

Section II - description

The present invention in General relates to elastomeric substrates or products that can reduce the microbial affinity and transmission. These products can be in the form of gloves or for work, laboratory tests, or medical and surgical applications, or catheters, balloons, condoms, or mats or sheets. These elastomeric products can be used to direct them, for example, hospital-acquired or acquired in hospital infections, which occur in thousands of patients each year. Although using aseptic methods can reduce the cases of these infections, there remains a significant risk. In recent years, the need to improve the quality of patient care has received increased attention, particularly control infections. Disposable elastomeric articles, such as gloves that reduce the possibility of migration between inanimate objects and the patient or the healthcare worker and the patient, i.e., the transfer contact can greatly with iGATE the probability of infection of the patient acquired in hospital infection. This reduction of the possibilities of contamination can reduce the use of antibiotics, thus, reducing the rate at which microbes are becoming resistant to antimicrobial agents. Additional benefits from reduced speeds infection may include reducing the duration of patients ' stay in hospital, reduced health costs associated with the acquired hospital infections, and reduce the risk of infection to health care workers. Essentially, provided that at the present time on the market, there is no medical gloves with fixed or not leachable antimicrobial coating, there is a need for a disposable elastomeric gloves and other products, which have a mechanism of reducing the microbial affinity and transmission. There is also a need in the method of manufacturing such a product and method for determining the effectiveness of this product.

These elastomeric products have consistently associated antimicrobial coating that provides antimicrobial characteristics both during use and after disposal. Elastomeric product contains an elastomeric substrate having a first surface, and anti-microbial composition associated with the specified first surface, forming a noun or fixed against microblue coating, at least part of the first surface so that, when the antimicrobial coating is subjected to either a) the first option involving test dry leaching or based on agar plates Protocol EATS 147, or b) the second option, including test wet leaching or dynamic shake flask Protocol (ASTM E-2149-01, or C) both versions of the test zone of inhibition, antimicrobial coating produces no zones of inhibition. The substrate may be further put to the test contact of the transfer of relatively short duration, such as less than about 6 minutes, which demonstrates the efficiency of the biocide, which produces a decrease in the concentration of bacteria which can be transferred to the specified first surface, by an amount at least log101. Preferably, substantive antimicrobial coatings can reduce the concentration of microbes on the first surface by an amount at least log103 or log104 or more.

In another object, the present invention describes a method of irreversible deposition of antimicrobial compounds on the external surface of the elastomeric product or substrate. Different types of antimicrobial compounds or polymers can be used according to the invention, since PR is tuomikoski agent capable of binding or complexation with the surface of the elastomeric substrate. The antimicrobial coating may be a combination of various biocides, each of which can be aimed at specific species of microbes. These biocides that are substantive antimicrobial coating may be selected from at least one of the following: Quaternary ammonium compound, policestations amine, halogen containing halogenoalkane, the compound of bromine, chlorine dioxide, chlorhexidine, thiazole, thiocyanate, isothiazolin, cyanobutane, dithiocarbamate, thioketone, triclosan, alkylsulfonyl, alkyl-amino-alkyl-glycine, biguanides, salt dialkyldimethylammonium, cetrimide, hydrogen peroxide, 1-alkyl-1,5-diazapentane or cetylpyridinium. Of these samples, preferably, an antimicrobial agent is a cationic polymer, such as polyhexamethyleneguanidine (PGMB), chlorhexidine, alkyl-amino-alkyl-glycine, 1-alkyl-1,5-diazapentane, salt dialkyldimethylammonium, cetrimide.

The substrate may be selected from a variety of elastomeric materials. For example, the substrate may be natural rubber and/or synthetic polymeric grids/grids, such as nitrile rubber, vinyl copolymer materials styrene-ethylene-butylene-styrene (SEBS) or styrene-butadiene-styrene (SBS).

The method or processing technology to ensure substantive or non-volatile p is otivational the surface of the elastomeric substrate comprises binding of antimicrobial agents with the substrate, having a polar surface, or a reactive surface. Antimicrobial coatings are produced and applied to the elastomeric substrate on at least the first surface in accordance with the heat-activated treatment. This processing can be carried out either by using the technologies of spraying it or immersing the formed product in the tank for immersion with antimicrobial solution.

In the processing method by sputtering is preferably used an air supply system of the aerosol during the chlorination process or after him. The air pressure feed spray is about 40 pounds per square inch, and the velocity of the flow of the solution is about 2-4,75, or 5 pounds per square inch, preferably about 3-4 pounds per square inch. Turning the camera can be a drum, such as in a washing machine, and it is heated to a temperature of from about 60°C (~140°F) up to about 82,2°C (~180°F), preferably, from about 64°C (~147°F or 71°C (~160°F) up to about 75°C. In the bath solution can be heated to a temperature of from about 40.5°C (105°F) or to 43.3°C (110°F) to about 75°With (~167°F), preferably from about 46°C (~115°F) to 63°C (~145°F) or as 65.5°C (150°F), more preferably, about 48-55°C (~120-133°F). When the actual temperature conditions change according to specific parameters, specialists PON the IDT, the effective periods of time, during which apply antimicrobial treatment will also change accordingly. As suggested here, the effective periods of time can be as short as 8 or 9 minutes, but preferably, they comprise at least about 12 minutes, more preferably, about 15 to 20 or 30 minutes. You can use over long periods of time about 40, 45, or 60 minutes. It seems that the longer the period of time during which products are in contact with the antimicrobial solution in terms of heat, the greater the durability and stability of the antimicrobial coating remaining on the surface of the treated product. Antimicrobial coatings can be characterized by the degree to which the antimicrobial coating is connected and can be first or second, or both the test zone of inhibition described here, where the first option involves testing Protocol dry leaching, and the second option involves testing Protocol wet leaching.

Although not to be bound by any particular theory, I believe that either the heating antimicrobial solution, or the application of heat treatment, or a combination of both can support more effective linking of the specified antimicrobial Agay is the one with the specified substrate. Application of antimicrobial agents in hot conditions (e.g., ≥ around 100°F (~37.8°C)assist, in part, the orientation of antimicrobial molecules on the surface of the elastomeric substrate and to create a more effective matching of antimicrobial agents with each other and/or to the coated surface, making it difficult to leach. Whereas previously a large number of antimicrobial compounds was necessary to correctly and completely covered with the outer surface of the gloves, I believe that the more rapid orientation of the molecules allows the floor with a smaller number of antimicrobial compounds for coating an elastomeric substrate to achieve the same results, if only the simultaneous sudden increase in efficiency is not destroyed after the completion of processing the application when heated. Therefore, these savings amount of antimicrobial material actually allows you to achieve more savings coatings for the same amount of material. For example, the concentration of antimicrobial agent added to the surface of the elastomeric substrate could be reduced even below about 0.005 g to the glove. In the smallest ways spraying requires a temperature higher than that used in the methods of immersion in the bath to maintain the temperature of the antimicrobial solution is in the air. However, the degree of advantage or effective improvements noun attachment antimicrobial coating to the surface of the substrate, as it seems, is aligned with a further increase in temperature. Therefore, the preferred temperature range lies from about 105°F (40,5°C) to about 185°F (85°C), depending on the use of a particular method of application.

Another beneficial object of gloves or other products of the present invention is that the elastomeric substrates and products subjected to this treatment can have long-lasting antimicrobial properties. Antimicrobial coating formed on the surface of the gloves is not leached in the presence of water substances, strong acids and bases and organic solvents. Because antimicrobial agents are associated with surface gloves, antimicrobial effect, as it seems, chemically longer, therefore, is to provide an antimicrobial effect of longer duration.

In addition, the sustainable nature of the antimicrobial coating can minimize the transfer of germs and the development of resistant to antibiotics, strains of bacteria. Traditional agents leach from the surface of the product, such as a glove, and should be spent on microbes to be EF is subjective. When using such conventional agents, germ poisoned and is eliminated only if the dose is lethal. If the dose is sublethal, microbes can adapt and become resistant to this agent. As a result, hospitals are reluctant to enter such agents in a sterile environment. Moreover, because these antimicrobial agents have been used up in the process, the effectiveness of antimicrobial treatment decreases during use. Antimicrobial compounds or polymers used in the present invention are not spent on microbes. Rather, these antimicrobial agents break the membrane of the microbes that are present on the surface of the gloves.

The presence of antimicrobial coverage and even distribution on the surface of the coated product can be verified or determined using the indicator dye, such as tetrabromfluorestsein (eosin yellowish),

When this dye is applied to the surface with antibacterial treatment, the surface becomes reddish in color only in the presence of a positively charged antimicrobial coating, such as polyhexamethyleneguanidine (PGMB). This dye is negatively charged, therefore, it will bind to the cationic antimicrobial molecules on the surface the surface.

Gloves or other products that the consumer can put on his or her body, antimicrobial agents, preferably, remain in the first or exterior surface away from the skin bearing, which has contact with the second or inner surface products. Preferably, the glove may have a textured surface. The key benefit of using the textured surface is relatively textured surface is that the textured surface has fewer points of contact by touching a contaminated object that allows a smaller number of organisms captured by the surface of the glove, thus, reducing the likelihood of contact transfer of microorganisms from the surface of the object on the glove.

A.

The elastomeric article such as a glove, processed according to the present invention, may be first formed using multiple processes, which may include the stage of immersion, spraying, bating, drying and crosslinking. To illustrate, here is an example of the immersion process for forming gloves, although you may be used and other processes for forming various products with different shapes and characteristics. For example, a condom can be formed essentially in the same way, although some condition which I process may differ from those that used to form the glove. Although there is described and shown a periodic process, it should be clear that paliperidone and continuous processes can also be used in the present invention.

The glove 10, as in the drawing, may be formed on a hand mold, called "shaper". This shaper can be made from any suitable material, such as glass, metal, porcelain, or the like. The surface of the shaper can be textured or smooth, and forms at least a portion of the surface of the glove, which will be produced. The glove comprises an outer surface and an inner surface. The inner surface is a surface usually in contact with the user.

The driver passed through a preheated oven, to evaporate all the water present. The driver then can be immersed in the bath, usually containing a coagulant, the source powder, a surfactant and water. The coagulant may contain calcium ions (from, e.g., calcium nitrate), which provide the ability to precipitate the latex polymer on the shaper. Powder may be powder of calcium carbonate, which helps to separate the finished glove from the former. Surfactant about who has superior wetting, to avoid the formation of a meniscus and trapping air between form and coated latex, particularly in the area of the cuff. However, it may be used any suitable coagulating composition, including those described in U.S. patent number 4310928 Joung, fully included here by reference. Residual heat vaporizes the water in the coagulating mixture, leaving, for example, calcium nitrate, powder of calcium carbonate and surfactant on the surface of the shaper. Although there is described the process of coagulation, it should be clear that other processes may be used to form products of the present invention, which do not require coagulant. For example, in some embodiments, the execution of the invention can be used in the process is solvent-based.

Covered shaper then immersed in a bath of the polymer, which, in General, is a natural rubber latex or a synthetic polymer latex. The polymer present in the bath, includes an elastomeric material that forms the body of the gloves. In some embodiments, execution of elastomeric material or the elastomer comprises natural rubber, which may be provided as a compounded natural rubber latex. Thus, the bath may contain, for example, compounded by the nature of the capacity rubber latex, stabilizers, antioxidants, activators knitting, organic accelerators, vulcanizers, and the like. In other versions of the invention the elastomeric material may be a nitrile-butadiene rubber, and in particular carboxypropanoyl nitrile-butadiene rubber. In other versions of the invention the elastomeric material may be a block copolymer of styrene - ethylene - butylene - styrene block copolymer, styrene - isoprene - styrene block copolymer, styrene - butadiene - styrene block copolymer, styrene - isoprene block copolymer styrene - butadiene synthetic rubber from isoprene and chloroprene, polyvinyl chloride, silicone rubber, polyurethane or a combination thereof.

The stabilizers may include surface-active substances such as phosphates. Antioxidants can be phenolic, for example 2,2'-Methylenebis(4-methyl-6-tert-butylphenol). Activator stitching may be zinc oxide. Organic accelerating additive may be dithiocarbamates. The vulcanizer may be sulfur or sulfur-containing compound. To avoid the formation of crumbs, stabilizer, antioxidant, activator, accelerator additive and vulcanizer can first be dispersed in water using a ball mill and then combined with the latex polymer.

In the process of dipping the coagulant on the formation of the body causes the portion of the elastomer to become locally unstable and coagulate on the surface of the shaper. Elastomer cholesterol, capturing particles present in the coagulating composition on the surface of the coagulating the elastomer. The shaper is then removed from the bath and coagulated layer allow to fully coalesce, thus forming a glove. The shaper is immersed in one or more baths sufficient number of times to achieve the desired thickness of the glove. In some versions of the invention, the glove may have a thickness of from about 0.004 inches (is 0.102 mm) to about a 0.012 inch (0,305 mm).

The driver then can be immersed in the tank leaching, which circulates hot water to remove water soluble components, such as residual nitrates of calcium and proteins contained in natural rubber latex, and excess chemicals are processed from the latex of a synthetic polymer. This leaching process can, in General, continue for about 12 minutes at a water temperature of about 120°F. the Glove is then dried on the shaper for solidification and stabilization of gloves. It should be clear that a variety of conditions, processes and materials used to form the glove. Other layers may be formed by incorporating additional processes dive. Such layers can be used to include additional characteristic features in lane is ATCU.

The glove is then sent to the workplace curing, where the elastomer vulcanizer, usually in an oven. Place curing first evaporates all the remaining water in the floor on the driver and then continues the process to a higher temperature vulcanization. Drying can occur at a temperature of from about 85°to about 95°C., and the curing can proceed at temperatures from about 110°to about 120°C. for Example, the glove may be vulcanized in the same oven at a temperature of 115°C for about 20 minutes. Alternatively, the furnace may be divided into four different zones, and the driver passes through a zone of elevated temperatures. For example, a furnace may have four zones, with the first two zones are drying, and the latter two zones are intended primarily for vulcanization. Each of the zones may have a slightly higher temperature, for example, the first area may be a temperature of about 80°C., the second zone is from about 95°C, the third zone with about 105°C and the end zone with a temperature of about 115°C. the residence time of the shaper within each zone may be about ten minutes. Accelerating additive and vulcanizer contained in the latex coating on the shaper, used for the crosslinking of the elastomer. Vulcanizer forms the sulfur bridges between different segments of the elastomer, and accelerating additive used the Ute, to stimulate rapid formation of sulfur bridge.

After curing, the driver may be moved to the working place of removal, where the glove is removed from the shaper. Workplace withdrawal may include automatic or manual removal of the glove from the former. For example, in one embodiment, the glove is removed manually and turn when it is removed from the shaper. When the inversion gloves, so that the outer side of the glove on the former becomes the inner surface of the glove. It should be clear that any method of removing gloves with shaper can be used, including the removal process directly by air, which does not lead to the inversion of the glove.

The cured glove or many hardened gloves can then be subjected to various processes of post-processing, including the use of one or more data processors, at least one surface of the glove. For example, the glove may be galogenirovannami to reduce the stickiness of the inner surface. Halogenoalkane (e.g., chlorination) may be performed in any suitable way, including: (1) direct injection box gaseous chlorine in an aqueous mixture, (2) mixing bleach high density and aluminium chloride in water, (3) the electrolysis of a solution of sole is for the production of chlorinated water, and (4) acid bleaching. Examples of such methods are described in U.S. patent No. 3411982 Kavalir; U.S. patent No. 3740262 Agostinelli; U.S. patent No. 3992221 Homsy and others; US patent No. 4597108 Momose and U.S. patent No. 4851266 Momose, U.S. patent No. 5792531 Littleton and others, each of which is incorporated here fully by reference. In one embodiment, for example, chlorine gas Inuktitut in the flow of water and then served in charator (closed vessel)containing the glove. The chlorine concentration can be changed to control the degree of chlorination. The chlorine concentration can usually be at least about 100 parts per million (million share). In some versions of the invention, the chlorine concentration may be from about 200 parts per million to about 3500 parts per million In other versions of the invention, the chlorine concentration can be from about 300 parts per million to about 600 parts per million In the following versions of the invention, the chlorine concentration may be about 400 parts per million Duration stage chlorination can also be controlled to vary the degree of chlorination, and it can vary, for example, from about 1 to about 10 minutes. In some versions of the invention the duration of the chlorination may be about 4 minutes.

Still inside charator chlorinated glove or gloves can then be washed with water the Oh water at a temperature of about room temperature. This flush can be repeated if necessary. Gloves then you can crush it, and to divert excess water. At this point of the manufacturing process can be repeated washing and spend antimicrobial processing application according to the present invention in terms of heat.

The lubricating composition can then be added to XLERATOR followed by the process of collapse that lasts for about five minutes. The lubricant forms a layer on at least the area of the inner surface to further improve the donning gloves. In one embodiment, this lubricant may contain a component silicone or silicone-based. As used here, the term "silicone" usually refers to a broad family of synthetic polymers that have a recurring chain with links of silicon and oxygen, including polydimethylsiloxane and polysiloxane having a functional group with an associated hydrogen selected from the group consisting of amine groups, carboxyl, hydroxyl, ether, polyether, aldehyde, ketone, amide, complex, ester, and thiol, but not limited to. In some embodiments, execution of the invention, polydimethylsiloxane and/or modified polysiloxane can be used as a silicone component in accordance the present invention. For example, some suitable modified polysiloxane, which can be used in the present invention include polysiloxane modified with phenyl, polysiloxane modified with vinyl, polysiloxane modified with stands, polysiloxane modified with fluorine, polysiloxane modified with alkyl, polysiloxane, modified alkoxide, polysiloxane modified with amine, and combinations thereof, but are not limited to. Examples of available industrial silicones that may be used in the present invention include DC 365, available from Dow Corning Corporation (Midland, Michigan), and SM 2140, available from GE Silicones (Waterford, NY). However, it should be clear that any silicone, which provides a lubricating effect, can be used to enhance the performance of donning gloves. The solution of the lubricant is then drained from chlarotera, and it can be, if desired, reused. It should be clear that the lubricating composition may be applied at a later stage in the process of formation and may be applied using any method, such as dipping, spraying, immersion, printing, crushing or the like.

After various processes described above, the glove can be turned (if necessary)to set the NR is šnē surface of elastomeric products, for example gloves. Any treatment or combination of treatments can then be applied to the outer surface of the glove. Can be processed separate gloves, or many gloves can be processed simultaneously. Similarly, any treatment or combination of treatments can be applied to the inner surface of the gloves. Can be used with any suitable processing, including, for example, dipping, spraying, immersion, printing, crushing or the like.

Covered with a glove then you can put in thrashing device or other drying device and dried for from about 10 to about 60 minutes (e.g., 40 minutes) at a temperature of from about 20°to about 80°C. (for example, 40°C.). The glove can then be turned to expose the external surface, which can then be dried for from about 20 to about 100 minutes (for example, 60 minutes) at a temperature of from about 20°to about 80°C. (for example, 40°C.). Alternatively, at this stage of the production process it is possible to carry out the application of antimicrobial treatment according to the present invention.

Thus, antimicrobial treatment may be included in the current production process.

To apply antimicrobial composition on gloves, lots of gloves may be placed in a closed vessel where gloves are immersed is in an aqueous solution of the antimicrobial composition. In some versions of the invention, the antimicrobial composition may be added to the water so that as a result of processing the glove comprises from about 0.05 wt.% up to about 10 wt.% solid particles. In other versions of the invention, the antimicrobial composition may be added to the water so that as a result of processing the glove includes from about 0.5 wt.% to about 7 wt.% solid particles. In other versions of the invention, the antimicrobial composition may be added to the water so that as a result of processing the glove includes from about 2 wt.% to about 6 wt.% solid particles. In yet another embodiment, the antimicrobial composition may be added to the water so that as a result of processing the glove comprises about 3 wt.% solid particles. Gloves can be shaken, if desirable. The duration of the dive can be controlled to vary the degree of processing, and it may lie in the range of, for example, from about 1 to about 10 minutes. For example, the gloves may be immersed for a period of approximately 6 minutes. Gloves can be steeped many times as necessary to achieve the desired level of treatment. For example, the glove may be subjected to 2 cycles of immersion.

Gloves can then be washed, as necessary, to remove any excess proteomika the percent composition. Gloves can be washed in tap water and/or deionized water, as it is desirable. After gloves sufficiently washed, excess water is extracted from the tank, and gloves can be transferred to the thrashing device or other drying device. Gloves can be dried for from about 10 to about 60 minutes at a temperature of from about 20°to about 80°C. for Example, the outer surface of the glove may be dried for about 40 minutes at a temperature of about 65°C. the Gloves can then be turned to expose the inner surface, which can then be dried for from about 10 to about 60 minutes (e.g., 40 minutes) at a temperature of from about 20°to about 80°C.

For example, the inner surface of the glove may be dried for about 40 minutes at a temperature of about 40°C.

Antimicrobial polymer can be formed on the gloves in any amount suitable for this application. The amount of polymer formed on the glove can be adjusted to obtain the desired reduction of the microbial affinity, stability to their growth and resistance to contact the transfer, and such required amount may vary depending on the microbes that are likely to meet, and uses for which the product may be used. In some var is the ants perform the composition may be applied on the glove so that the resulting antimicrobial polymer is present in amount from about 0.05 wt.% up to about 10 wt.% the finished gloves. In other versions of the invention obtained antimicrobial polymer may be present in amount from about 1 wt.% to about 7 wt.% the finished gloves. In further embodiments, the execution of the received antimicrobial polymer may be present in amount from about 2 wt.% up to about 5 wt.% the finished gloves.

The production of elastomer, having a durable, non-volatile antimicrobial coating on the substrate, is unusual in that it is often difficult to create an antimicrobial layer, which stably associated with the surface, and demonstrates a satisfactory level of effective antibacterial functionality. Antimicrobial activity of the biocide depends greatly on several factors. The most important of them is the exposure time, concentration, temperature, pH and the presence of ions and organic matter. In addition to this complexity, the efficiency associated with the surface of bactericides directly affects the ability of these molecules to be bioavailable. This requires orientation of active molecules on the surface of the material so that it could directly interact with the cell.

In part, the present invention is built on research is the training, which was described in the application U.S. No. 2004/0151919, the contents of which are incorporated here by reference. In this application we describe the use and immobilization Milanovich Quaternary ammonium compounds or organosilane composition in a suitable solvent that is effective when the outer binding glove. In particular, they discussed the use of various combinations of 3-(trimethoxysilyl)propyltrimethylammonium in methanol in the production line Microbeshield®, industrial available from Aegis Environments, Midland, Michigan. For example, the product description AEM 5700 represents a 43%solution of 3-(trimethoxysilyl)propyltrimethylammonium in methanol (with small percentage contents of other inactive substances), and AEM 5772 represents a 72%solution of 3-(trimethoxysilyl)propyltrimethylammonium in methanol (with small percentage contents of other inactive substances).

In other studies, the lack of effectiveness of AEM 5700 as surface-active antimicrobial drug on medical gloves or gloves for patient care indicates the likely absence of orientation of its molecules on the surface of the gloves, giving a poor performance, as determined by appropriate evaluation methods. One way to overcome this is about the limit consists in modifying the surface of the gloves before adding a biocide. An alternative way is to use another active substance which is less restrictive for its application. This purpose was proposed alternative surface biocide, polyhexamethyleneguanidine. It is shown that this active substance is retained on the surfaces, provides a short time disinfection, and reportedly has a broad spectrum of effectiveness. The results of our experimental tests are summarized in section III - empirical information.

Biguanidine group is very alkaline group, which remains in cationic (protonated) form to a pH of about 10, and interacts strongly and very quickly with anionic substances. Polyhexamethyleneguanidine (PGMB) has strongly basic groups of biguanide associated with hexamethylenamine the spacers, to provide a polymer with an average degree of polymerization of 12. The mechanism of action of PGMB on bacteria and fungi is the destruction of the external cell membranes through 1) the substitution of divalent cations, which provide structural integrity, and 2) binding to phospholipid membranes. These actions will provide the disorganization of the membrane and the subsequent termination of the entire metabolic process, which relies on the membrane structure, such as energy production, the strength of the movement of protons, as well as transfers. PGM is particularly effective against Pseudomonas. There are a significant number of microbiological evidence that the destruction of the cell membrane is a deadly phenomenon. As soon as the outer membrane is open, molecules PGMB can reach the cytoplasmic membrane, where they bind with negatively charged phospholipids.

There are a significant number of microbiological and chemical evidence that the destruction of the cytoplasmic membrane is a deadly phenomenon. It can be simulated in the laboratory production of small single layer of phospholipid vesicles (50-100 nm in diameter)that load dye. Adding PGMB in the range of physiological concentrations causes rapid destruction of the vesicles (observed by monitoring the release of the dye) and the time constant of the reaction corresponds to a high rate disinfection.

The study of artificial multilayer vesicles composed of various lipids, showed that PGMB is associated strongly with anionic or non-ionic membranes. Very strong affinity PGMB with negatively charged molecules means that it can interact with some conventional anionic (but not cationic or non-ionic) surfactants used in opaque compositions. However, it is compatible with polyvinyl alcohol, C is hostitelmi based on cellulose and products based on starch and works well in emulsion systems of polyvinyl acetate and a copolymer of ethylene and vinyl acetate. It also works well in the emulsion based on silicone and cationic electrophoretic. Simple compatibility tests quickly show whether PGMB compatible with this composition, and stable systems can often be designed with granular anionic components.

Molecule PGMB can contact the glove through the complex interplay of charge, associated with areas of gloves, which have a negative charge. Once bacteria reach close proximity to the molecule PGMB, PGMB is moved to the most negatively charged bacterial cell. Otherwise, hydrophobic region of biguanide can interact with hydrophobic regions of the gloves, providing a charged regions of molecules PGMB availability for interaction with bacteria and penetration through the membrane. The true mechanism is probably a mixture of both types of interaction. Although the specific mechanism holding the glove is not fully understood at the present time, our most recent data on leaching suggest that in fact it is held on the glove and not leached, as determined by the testing methods ASTM described in the empirical section below.

Section III - empirical

Gloves or deposited heated solution or immersed in the heated bath, containing protivovspenivayushchie agent, Quaternary ammonium compound, and cetylpyridinium. Alternative antimicrobial agent was also tested polyhexamethyleneguanidine (PGMB). The solution was heated in jet burner or in a heated canister before entering into the sprayer when the collapse in the pressurized air dryer. This method allows you to process only the outer side of the glove more efficiently and with less of a solution and still provide desirable antimicrobial effectiveness, better adhesion of the antimicrobial agents, reducing leaching agent from the surface, and eliminating potential skin irritation of the user due to the constant contact between the biocide and skin health worker. Covered when diving gloves remain closed so that any antimicrobial coating that was on the way to the inside of the gloves, remaining open around the cuff, not subjected to further the inner surface of the gloves. Was investigated the external surface of the glove. Used textured shapers, and not textured to estimate the surface area in contact with the microorganisms.

A.

To assess whether the applied antimicrobial coating on elastomeric materials school is the super stable and is not leached from the surface of the substrate, use two tests. First, in accordance with the test Protocol of the American Association of textile chemists and colorists 147 in the test on dry leaching was given a sample of the glove material, treated against microbes, and put it on the agar plate, inseminated known number of populations of organisms on the surface of the plate. The plate is incubated for about 18-24 hours at a temperature of about 35°C or 37°C±2°C. and Then evaluated this agar plate. Any leaching of the antimicrobial agent from the glove material would lead to a growth of microbes in the area of incubation. Presented in table 1A results for several samples tested were not found any zones of inhibition, it indicates that the antimicrobial agent is not leached from any of the samples gloves.

Secondly, in the test zone of inhibition when wet leaching Protocol testing American society for testing and materials (ASTM) E 2149-01, including dynamic shake flask, we have put a few samples of gloves with antimicrobial coating of 0.3 Molina solution of phosphate (KH2PO4) in buffer with pH ~6.8 cm. Sample gloves were left for 24 hours in the solution and then was extracted with distilled solution. Conditions of extraction were included about 30 minutes of p is at room temperature (~23°C) with 50 ml of buffer into the Erlenmeyer flask, 250 ml The flask was shaken on a hand shaker for 1 hour ±5 minutes. About 100 microliters (ál) distilled solution was added into a hole 8 mm in inseminated agar plate and allowed to dry. After about 24 hours at 35°C±2°C agar plate was examined for signs of inhibiting the activity or growth of microbes. The absence of zones of inhibition, as shown in table 1B, it implies the absence of leaching antimicrobial agent from the surface of the gloves in the pooled solution or its effect on the microorganisms on agar plate. The data presented in tables 1A and 1B represent the results when the antimicrobial coating is applied in a washing machine.

In order to further develop test protocols for the zone of inhibition and testing contact transfer, the desired inoculum can then be placed aseptically on the first surface. You can use any number of the preferred inoculum, and in some versions of the invention the amount of about 1 ml is applied to the first surface. In addition, the inoculum can be applied on the first surface in any desired area. In some examples, the inoculum can be applied to the area size of about 7 inches (178 mm) 7 inches (178 mm). The first surface may be made of any material which, can be sterilizovanny. In some embodiments, the first surface can be made of stainless steel, glass, porcelain, ceramics, artificial or natural leather such as pigskin, or the like.

The inoculum can then be allowed to remain on the first surface within a relatively short period of time, for example about 2 or 3 minutes before the estimated product that is a substrate for migration brought into contact with the first surface. The substrate for transfer can be any type of product. Specific applicability may be, in some cases, for testing or surgical gloves. The substrate for transfer, for example, the glove must be handled aseptically. Where the substrate for transfer is a glove, the glove can be placed on the left and right hands of the experimenter. One glove can then be brought into contact with infected first surface, provided that the contact is resilient and straightforward to minimize the error. Feel the glove can then be immediately removed with the use of the other hand and placed into the flask containing the desired amount of sterile buffered water (prepared previously)to be extracted transferred germs. In some cases, the glove can is to be placed into the flask, containing about 100 ml of sterile buffered water, and tested for a set amount of time. Otherwise, the glove may be placed into a flask containing an appropriate amount of Letheen Agar Base (available from Alpha Biosciences, Inc. Baltimore, Maryland)to neutralize antimicrobial treatment for later evaluation. The flask containing the glove can then be placed on a reciprocating movement of the shaker and processed at a speed of from about 190 cycles per minute to about 200 cycles per minute. The flask can shake during any desired time and in some cases to shake for about 2 minutes.

The glove can then be removed from the flask, and the solution is diluted, as desired. The desired amount of solution can then be placed on at least one agar plate for sample. In some cases, about 0.1 ml of the solution can be placed on each plate for the sample. The solution on the plates for samples may then be incubated for the desired amount of time to allow the microbes to multiply. In some cases this solution may be incubated for at least about 48 hours. Incubation can occur at any appropriate temperature to allow microbial growth, and in some sluchajnoe to occur at a temperature from about 33°to about 37°C. In some cases, the incubation can occur at a temperature of about 35°C.

After the incubation is completed, present the microbial count and the results are reported as colony forming unit (CFU)/ml, the Percentage recovery of microorganisms can then be calculated by dividing the extracted microbes in CFU/ml by the number present in the inoculum (CFU/ml), and multiplying the value by 100.

Another object is to evaluate the effectiveness of how quickly applied antimicrobial agents to disinfect, was used in direct contact test, rapid bactericidal action, developed by Kimberly-Clark Corporation. This test better simulates the working of the situation in reality, in which microbes are transferred from the substrate to the glove through direct contacts small duration. Also this test allows us to assess quickly whether eliminates contact with the surface of the glove microbes in one position, while the testing Protocol-based solution ASTM E 2149-01 tends to provide many opportunities for contact and disinfection, which are less realistic in practice.

The inoculum was applied from a known amount of microbes on the surface of the gloves with antimicrobial treatment. After about 3-6 minutes estimated the number of microbes, which remained on the poverhnosti treated gloves. Any sample with a logarithmic (log10) decrease of about 0.8 or more is effective and demonstrates a satisfactory level of performance. As in the case of the test contact of the transfer, held by current ASTM protocols, the decrease in the concentration of microbes on the order of about log101 is effective. It is desirable that the concentration of microbes can be lowered to a value of about log103, or, more preferably, about log104 or more. Table 2 shows the relative effectiveness of disinfection after contact with the coated glove. The concentration of organisms on the surface is given in the initial zero point of time and at points 3, 5 and 30 minutes. As you can see, the resulting decrease in the percentage of the number of organisms at the beginning of time and after 3, 5 and 30 minutes is essential. Significantly, within the first few minutes of contact with the antimicrobial substance, destroyed virtually all (96-99% or more) of the microorganisms present.

B.

To test the antimicrobial efficacy polyhexamethyleneguanidine, such as that commercially available under the trademark Cosmosil®CQ from Arch Chemicals, Inc., Norwalk, Connecticut, nitrile gloves were processed for testing Protocol (ASTM 04-123409-106 Rapid Germicidal Kill Time" ("Fast bacteric is DNA disinfection"). Briefly, 50 μl of seasoned overnight culture of Staphylococcus aureus (ATCC #27660, 5×108CFU/ml) were applied to the glove material. After full contact time of about 6 minutes fabric gloves were placed in a neutralizing buffer. Surviving organisms were extracted and diluted broth Letheen. Aliquots flat spread on agar plates Tryptic Soy. Plates were incubated for 48 hours at 35°C. After incubation, the surviving organisms were counted and recorded colony-forming units (CFU). Expected reduction (log10) surviving organisms from the test material against control fabric:

Log10KOE/K. arr. - Log10CFU/use callback = reduction Log10.

It was found that the evaluated samples microtexturing nitrile gloves treatment polyhexamethyleneguanidine gives the decrease of the logarithm Stafilococcus aureus more than four when his machine drawing 0.03 g on the glove. The results are shown in table 3.

Table 3
NT#KC#Antimicrobial treatmentLog leaveResult
16745 Microsofty nitrile, control (RCR nitrile)3,72control
16846Hot spraying PGMBand(0.03 g/perch.) with Q2-5211+89-55,881,32
16948Hot spraying PGMBand(0.03 g/perch.) 89-7<2,38>4,7
16139Control PFE (report tests 9/15/2004) 87-1of 7.23control

PFE - containing powder glove.

Processing nitrile gloves by polyhexamethyleneguanidine demonstrates the reduction of organisms in more than one unit in logarithm manual sputtering without heating and the reduction of more than 5 log when the engine sputtering under the conditions of heating. Control nitrile material showed antimicrobial efficacy of three and four in the logarithm. These results are compared with a decrease in the deposited organisms (estimated from latex control material in table 4).

p> The inoculate: 8,08.

Zone of inhibition test was completed to evaluate the adhesion of the antimicrobial agent. The results are shown below in tables 6 and 7.

The present invention has been described in General and in more detail by means of examples. Words used are words of description and not of limitation. Specialists in this field understand that the invention is not limited to the specific disclosed variants of execution, but that modifications and changes may be made without departing from the scope of the invention as defined by the following claims or their equivalents, including other equivalent components, now known or developed that can be used in the scope of the present invention. Therefore, as long as the changes do not deviate from the scope of the invention, these changes must be considered as included here, and the attached claims should not be limited by the description of the preferred options.

of 1.6×105CFU/ml
Table 1B
"Wet leaching" ASTM E2149-01 Protocol
Sample # DescriptionThe inoculum levelThe zone of inhibitionThe test bodyThe size of the sample
1-1Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
1-22Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC "#27660)100 µl
1-33Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
2-1Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
2-2Nitrile substrateof 1.6×105CFU/mlno/td> S. aureus (ATCC #27660)100 µl
2-3Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
3-1Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
3-2Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
3-3Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
4-1Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
4-2Nitrile substratenoS. aureus (ATCC #27660)100 µl
4-3Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
5-1Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
5-2Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
5-3Nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl
Positively. control - 0.5% of ampela (by volume)of 1.6×105CFU/ml5 mmS. aureus (ATCC #27660)100 µl
Negative control - nitrile substrateof 1.6×105CFU/mlnoS. aureus (ATCC #27660)100 µl

of 1.2×103
Table 2
Bactericidal Express-analysis of the contact-transfer
The counting of microorganisms (CFU/ml)% reduction
Sample #The reference point3 minutes time5 minutes time30 minutes time0 h3 min5 min30 min
#1 Nitrile substrateof 3.8×103of 1.5×102n/a-96,8%99,9%99,99%-
#2 Nitrile substrate10n/a-99%99,99%--
#3 Nitrile substrateof 4.6×10340n/a-96,2%of 99.97%99,99%-
#4 Nitrile substrateof 3.6×103of 5.1×102n/a-97%99,6%99,99%-
#5 Nitrile substrateof 4.7×10370n/a-96,1%99,9%99,99%-
#6 Control - nitrile gloveof 1.2×105of 1.4×105of 1.3×105 of 1.4×105-b/sb/sb/s

1. Elastomeric product having reduced microbial affinity and transmission containing the body of the substrate, partially formed from natural or synthetic polymer latex having antimicrobial composition of antimicrobial agents stably associated with the first specified surface of the substrate, forming a homogeneous, non-volatile antimicrobial coating on at least the specified area of the first surface, the test of which there is no loss of antimicrobial molecules with the specified first surface in challenge mode on dry leaching, wet leaching or both tests on the zone of inhibition, and the specified elastomeric product is characterized by a decrease in the relative concentration of microbes at the said first surface by the amount at least log101 over a period of about 6 minutes

2. The elastomeric article according to claim 1, in which the aforementioned decrease in the relative concentration of microbes at the said first surface is equal to at least log103 for a period of at least about 15 minutes

3. The elastomeric article according to claim 1, in which the aforementioned decrease in the relative concentration Mick is mandatory on this first surface is the value of log 104.

4. The elastomeric article according to claim 1, which when applied indicator dye tetrabromfluorestsein (eosin yellowish) on the surface of the substrate of the specified products, processed antimicrobial substance, the surface of the substrate coated with an antimicrobial substance, becomes reddish.

5. The elastomeric article according to claim 1, in which the specified antimicrobial substance is at least one of the following substances: Quaternary ammonium compound, policestations amine, a halogen, a polymer containing halogen, the compound of bromine, chlorine dioxide, chlorhexidine, thiazole, thiocyanate, isothiazolin, cyanobutane, dithiocarbamate, thioketone, triclosan, alkylsulfonyl, alkyl-amino-alkyl-glycine, polyhexamethyleneguanidine, salt dialkyldimethylammonium, cetrimide, hydrogen peroxide, 1-alkyl-1,5-diazapentane or cetylpyridinium.

6. The elastomeric article according to claim 5, in which the elastomeric product contains from about 0.05 to about 10 wt.% antimicrobial polymer.

7. The elastomeric article according to claim 6, in which the elastomeric product contains from about 2 to about 5 wt.% antimicrobial polymer.

8. The elastomeric article according to claim 1, wherein said elastomeric substrate is selected from natural rubber latex, synthetic polymer latex, copolymer material is print materials styrene-ethylene-butylene-styrene (SEBS) or styrene-butadiene-styrene (SBS).

9. The elastomeric article according to claim 1, in which the given product is a glove or a condom.

10. The elastomeric article according to claim 1, in which the given product is a glove for medical or surgical use.

11. The method of manufacture is not leachable antimicrobial coating on the surface of the elastomeric substrate product including the selection of the elastomeric substrate having at least a first surface, the choice of antimicrobial solution containing an antimicrobial substance and protivovspenivayushchie agent and heated to a temperature of at least about 40.5°C~105°F), application of a specified antimicrobial agents in the application device by either spraying the spray nozzle antimicrobial solution, or immersing in a tub for mixing the specified antimicrobial solution to an effective amount of time to bind the specified antimicrobial coatings with specified substrate and receiving antimicrobial coating, when tested which there is no loss of antimicrobial molecules with the specified first surface in challenge mode on dry leaching, wet leaching or both tests on the zone of inhibition, and the specified elastomeric product is characterized by a decrease relative to the concentrations of microbes on the specified first surface by an amount at least log101 over a period of about 6 minutes

12. The method according to claim 11, wherein said antimicrobial solution is heated to a temperature of from about 43°C (~110°F) to about and 82.2°C (~180°F).

13. The method according to claim 11, wherein said antimicrobial solution containing protivovspenivayushchie agent, heated to a temperature from about 50°to about 70°C.

14. The method according to claim 11, in which in case of using this spray nozzles above solution is sprayed at a delivery pressure of about 30-50 psi (206,84 kPa - 344,74 kPa) and flow rate of the solution from about 1.25 to 5.5 psi (8,62 kPa - 37,92 kPa) specified on the first surface of the substrate, while the specified substrate is treated in a heated chamber of the device.

15. The method according to 14, in which the specified air pressure is about 40 psi and the flow rate of the solution is about 2-4,75 lbs/square inch.

16. The method according to 14, in which the specified camera heated to a temperature from about 60°C (~140°F) up to about 82,2°C (~180°F).

17. The method according to 14, in which is specified the heated chamber is a rotary drum.

18. The method according to claim 11, in which when using the specified tubs specified antimicrobial solution this solution is heated to a temperature of from about 40.5°C (105°F) to 75°C (~167°F).

19. The method according to claim 11, in which the specified e is atomarnoi product is subjected to a specified stage of applying for an effective amount of time, at least about 12 minutes

20. The method according to claim 11, in which the conduct or specified heating specified antimicrobial solution, or the specified application with heat treatment, or a combination of both, which stimulates more efficient binding of the specified antimicrobial agents with specified substrate.

21. The method according to claim 11, in which the specified antimicrobial substance is at least one of the following substances:
Quaternary ammonium compound, policestations amine, a halogen, a polymer containing halogen, the compound of bromine, chlorine dioxide, chlorhexidine, thiazole, thiocyanate, isothiazolin, cyanobutane, dithiocarbamate, thioketone, triclosan, alkylsulfonyl, alkyl-amino-alkyl-glycine, polyhexamethyleneguanidine, salt dialkyldimethylammonium, cetrimide, hydrogen peroxide, 1-alkyl-1,5-diazapentane or cetylpyridinium.

22. The method according to item 21, in which the elastomeric product contains from about 0.05 to about 10 wt.% antimicrobial polymer.

23. The method according to item 22, in which the elastomeric product contains from about 2 to about 5 wt.% antimicrobial polymer.

24. The method according to claim 11, wherein said elastomeric substrate is selected from natural rubber latex, synthetic polymer latex, copolymer materials styrene-ethylene-butylene-styrene (SEBS) or stiro the-butadiene-styrene (SBS).

25. The method according to claim 11, where the specified product is a glove or a condom.

26. The method according to claim 11, where the specified product is a glove for medical or surgical use.



 

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Hygienic glove // 2266075

FIELD: hygienic articles for medical industry, in particular, for medicinal and therapeutic purposes, used in hospitals, medical stations, and also for personal hygiene at home, in transport, and under tour and trip conditions.

SUBSTANCE: hygienic glove has fingers, palm and back parts, and cuff. Bags are fixed to palm and back parts, one of said bags being filled with shampoo or medicinal ointment and other bag being filled with washing or disinfecting solution. Also, each of said bags is equipped with pipe having threadable plug. Pipes are fixed on thumb or middle finger. Brush is made from rubber, sponge or porolon having thickness not in the excess of 5 mm and is fastened to pipes. Hygienic glove is provided with hygroscopic insert made in the form of glove. Pipes are positioned under brush. Hygroscopic insert may be made from cotton fabric. Hygienic glove may be provided with tapes, one of said tapes being fastened on glove cuff and other tape being fixed to insert.

EFFECT: increased efficiency and wider operational capabilities.

3 cl, 1 dwg

FIELD: medicine; gynecology.

SUBSTANCE: method includes abdominovaginal exposure from 5-7th day of menstrual period. Exposure is carried out with variable pulsating magnetic field generated by apparatus "Polus-2" at maximum intensity, frequency 50 Hz in intermittent duty. Duration of procedure is 20 minutes. Exposure is carried out daily, 3 times a day with interval between procedures not less than 2 hours. Method is noninvasive, improves implantation potential of endometrium due to blood circulation improvement in uterus arteries, and provides multilayer structure in endometrium.

EFFECT: higher incidence of pregnancy in patients with previous failures in extracorporal fertilisation.

3 ex

FIELD: articles of personal use.

SUBSTANCE: rubber glove with hand protective covering relates to surgical gloves and can be applied in medicine. Glove contains part of cuff and internal part. Glove contains dry covering from emulsified hand protective mixture. Mixture contains at least one water-soluble hygroscopic substance - humidifier, at least one water-soluble lubricant, at least one water-soluble SAS and at least one water non-soluble occlusive humidifier, which is evenly and completely dispersed in mixture. Mixture, which is applied on skin in process of glove putting on, is activated by moisture, produced by skin. Said glove is obtained by following method. Preliminarily heated form is submerged in water coagulant. After that form is submerged in water dispersion of rubber for formation of gel-like rubber layer and in water dispersive system for formation of smooth polymer covering. Rotation in dryer of glove with hand protective mixture of said composition with following drying.

EFFECT: increase of hand protection degree and simplification of glove putting on dry or wet hands and one glove on another.

31 cl, 19 tbl, 17 ex

FIELD: chemistry.

SUBSTANCE: elastometic products have low microbial affinity. The product has a substrate body partially moulded from natural or synthetic polymer latex having an antimicrobial composition from antimicrobial substance, tightly joined to the first surface of the said substrate, forming a uniform non-volatile antimicrobial coating on at least a region of the said first surface. When testing the product there is no loss of antimicrobial molecules from the said first surface in dry leaching testing conditions, in wet leaching conditions or both tests on the inhibition zone. The elastomeric product is characterised by fall in relative concentration of microbes on the said first surface by a value of at least log10 1 within a period of about 6 minutes.

EFFECT: increased duration of the protective effect and restricted transfer of microbes from the surface of the product to surrounding surfaces.

26 cl, 1 dwg, 8 tbl

FIELD: chemistry.

SUBSTANCE: invention describes polymeric latex made through radical emulsion polymerisation, containing polymer particles which contain structural units obtained from at least one conjugated diene component, where the said polymer particles contain at least one hard phase segment having glass transition point (Tg) of at least 50°C and at least one soft phase segment having glass transition point (Tg) not higher than 10°C, where total number of hard phase segments constitutes 2-40 wt %, and total number of soft phase segments constitutes 60-98 wt % relative total weight of the polymer particles, where Tg is measured using a differential scanning calorimetry (DSC) method in accordance with ASTM D3418-03, and the said polymeric latex is resistant to electrolytes, defined as critical coagulation concentration less than 30 mmol/l CaCl2 (defined for overall content of solid particles of latex 0.1 at pH 10). Described also is a method of producing the said latex. The invention describes a composite polymeric latex composition suitable for dip moulding articles, which contains the said polymeric latex; described also is a film made from said polymeric latex and a method of making said film, as well as a latex article containing said film.

EFFECT: polymeric latex which may be contained in the composite latex composition which has prolonged stability and possibility of use for conventional dip moulding processes for making latex articles where there is no need for cross-linking the composition either with radiation or with a cross-linking agent.

22 cl, 2 dwg, 3 tbl, 6 ex

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