Method of obtaining black walnut tincture

FIELD: medicine.

SUBSTANCE: extraction of young immature fruits with diametre not more than 3 mm is carried out. Fresh raw material is preliminarily grinded, covered with 60% alcohol with ratio 1:2 and extraction with addition of propylene glycol in amount 1% at temperature 50° during 5 hours is carried out, extract is poured out. Second stage of extraction is performed at room temperature during 15 hours with ratio raw material extractant 1:2. Raw material is squeezed, extracts are poured together, recovered material is filtered.

EFFECT: increasing yield of active substances.

1 tbl, 1 ex

 

The invention relates to medicine, namely to create herbal medicines used in the regulation of thyroid function and enhance immunity.

A known method of manufacturing a tincture of black walnut by combining the fruit of the black walnut with an aqueous solution of alcohol and soaking them in the interval of time at room temperature [Asthita devi dasi "Practical methods of healing from cancer." Abstract notes on the book by Dr. Klark "The Cure for all Cancer". Of OCK, 1997, Asthita, 1997, p.46].

In this way, the infusion is recommended within 2 days of the alcohol in an aqueous solution of 50%.

The disadvantage of this method is not a complete extraction of active substances.

Tincture of black walnut can be prepared from the dried raw material 4 Homeopathic Pharmacopoeia Schwabe in the ratio of 1:10 (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by V.I. Fisherman, Moscow, 1967).

1. Dried nuts with allopatrically break into small particles hammer.

2. The tincture is made in the ratio of 1:10 by the method of percolation, this 1 kg of crushed dried nuts pour a 5-fold amount of extractant (5 l) 50% concentration of ethyl alcohol and allowed to stand for 24-48 hours, then drain ek is tragant fully and measure the volume of the extract. The raw material is extracted twice more with fresh extractant so that the combined extracts was 10 L. Each step infusion lasts 24-48 hours.

3. The combined extracts settle at a temperature of 10°C for two days and filtered.

It turns out tincture 1:10.

There is also known a method of preparation of the black walnut by combining the fruit of the black walnut with an aqueous solution of alcohol and soaking them in the interval of time at room temperature, characterized in that when combining them on 100 parts by weight of black walnut take from 100 to 1000 parts of a solution of alcohol containing alcohol in the solution is from 40 to 96 vol.%, and insisting spend from 3 to 21 days (RU patent No. 2135200).

This method is taken as a prototype.

The technical object of the present invention is to improve the quality tinctures by increasing the output of existing substances and reduce the time of processing.

This technical problem is solved by the proposed method.

The raw material is a young immature fruit diameter not exceeding 3 mm, collected in the period of their maturation. Procurement lead in dry weather, starting at noon. Fresh raw grind, fill 60% alcohol in the ratio of 1:2 and the extraction is carried out with the addition of propylene glycol in the amount of 1%, at 50° for 5 hours, the extract is drained./p>

The second stage of extraction at room temperature for 15 hours at a ratio of raw material:solvent 1:2. The raw material is squeezed, extracts pooled. The extract is filtered.

Specific example No. 1

100 g minced immature fruit of the black walnut pour 200 ml of 60% alcohol, add 1 ml of propylene glycol and infused for 5 hours at 50° for 5 hours, removing the drain and pour 200 ml of 60% alcohol and infused for 15 hours. The extract is filtered and unite.

The quantitative content of the active substances in the extract was determined by the tannins, and flavonoids.

Tannins were determined by the method of permanately. The amount of flavonoids was determined by spectrophotometry, differential method with aluminum chloride in acetic acid environment. Studies have shown an increase in the yield of tannins and amounts of flavonoids compared to the prototype.

The results are presented in table 1.

Carried out on outbred rats pharmacological tests showed the presence of the resulting tincture immunomodulatory actions, and actions to normalize thyroid function.

Thus, the proposed method for homeopathic tinctures allows to increase the output of existing substances and reduce the ü extraction time.

Table No. 1
Quantitative content of the active substance
No.TanninsFlavonoids
Found, %Found, %
1 prototype0,92,3
2 the proposed method1,84,3

A method of obtaining a tincture of the fruit of the black walnut by extraction immature fruit of the black walnut diameter not exceeding 3 mm ethanol extraction was carried out in two stages, the first stage is 60%alcohol in the presence of propylene glycol in the amount of 1% at a ratio of 1:2 and 50° for 5 h, the second stage is 60%alcohol at a ratio of 1:2 for 15 h, the extracts are combined and filtered.



 

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