Method of obtaining black walnut tincture
SUBSTANCE: extraction of young immature fruits with diametre not more than 3 mm is carried out. Fresh raw material is preliminarily grinded, covered with 60% alcohol with ratio 1:2 and extraction with addition of propylene glycol in amount 1% at temperature 50° during 5 hours is carried out, extract is poured out. Second stage of extraction is performed at room temperature during 15 hours with ratio raw material extractant 1:2. Raw material is squeezed, extracts are poured together, recovered material is filtered.
EFFECT: increasing yield of active substances.
1 tbl, 1 ex
The invention relates to medicine, namely to create herbal medicines used in the regulation of thyroid function and enhance immunity.
A known method of manufacturing a tincture of black walnut by combining the fruit of the black walnut with an aqueous solution of alcohol and soaking them in the interval of time at room temperature [Asthita devi dasi "Practical methods of healing from cancer." Abstract notes on the book by Dr. Klark "The Cure for all Cancer". Of OCK, 1997, Asthita, 1997, p.46].
In this way, the infusion is recommended within 2 days of the alcohol in an aqueous solution of 50%.
The disadvantage of this method is not a complete extraction of active substances.
Tincture of black walnut can be prepared from the dried raw material 4 Homeopathic Pharmacopoeia Schwabe in the ratio of 1:10 (Homeopathic medicines, guide and manufacturing, Wilmar Schwabe, edited by V.I. Fisherman, Moscow, 1967).
1. Dried nuts with allopatrically break into small particles hammer.
2. The tincture is made in the ratio of 1:10 by the method of percolation, this 1 kg of crushed dried nuts pour a 5-fold amount of extractant (5 l) 50% concentration of ethyl alcohol and allowed to stand for 24-48 hours, then drain ek is tragant fully and measure the volume of the extract. The raw material is extracted twice more with fresh extractant so that the combined extracts was 10 L. Each step infusion lasts 24-48 hours.
3. The combined extracts settle at a temperature of 10°C for two days and filtered.
It turns out tincture 1:10.
There is also known a method of preparation of the black walnut by combining the fruit of the black walnut with an aqueous solution of alcohol and soaking them in the interval of time at room temperature, characterized in that when combining them on 100 parts by weight of black walnut take from 100 to 1000 parts of a solution of alcohol containing alcohol in the solution is from 40 to 96 vol.%, and insisting spend from 3 to 21 days (RU patent No. 2135200).
This method is taken as a prototype.
The technical object of the present invention is to improve the quality tinctures by increasing the output of existing substances and reduce the time of processing.
This technical problem is solved by the proposed method.
The raw material is a young immature fruit diameter not exceeding 3 mm, collected in the period of their maturation. Procurement lead in dry weather, starting at noon. Fresh raw grind, fill 60% alcohol in the ratio of 1:2 and the extraction is carried out with the addition of propylene glycol in the amount of 1%, at 50° for 5 hours, the extract is drained./p>
The second stage of extraction at room temperature for 15 hours at a ratio of raw material:solvent 1:2. The raw material is squeezed, extracts pooled. The extract is filtered.
Specific example No. 1
100 g minced immature fruit of the black walnut pour 200 ml of 60% alcohol, add 1 ml of propylene glycol and infused for 5 hours at 50° for 5 hours, removing the drain and pour 200 ml of 60% alcohol and infused for 15 hours. The extract is filtered and unite.
The quantitative content of the active substances in the extract was determined by the tannins, and flavonoids.
Tannins were determined by the method of permanately. The amount of flavonoids was determined by spectrophotometry, differential method with aluminum chloride in acetic acid environment. Studies have shown an increase in the yield of tannins and amounts of flavonoids compared to the prototype.
The results are presented in table 1.
Carried out on outbred rats pharmacological tests showed the presence of the resulting tincture immunomodulatory actions, and actions to normalize thyroid function.
Thus, the proposed method for homeopathic tinctures allows to increase the output of existing substances and reduce the ü extraction time.
|Table No. 1|
|Quantitative content of the active substance|
|Found, %||Found, %|
|2 the proposed method||1,8||4,3|
A method of obtaining a tincture of the fruit of the black walnut by extraction immature fruit of the black walnut diameter not exceeding 3 mm ethanol extraction was carried out in two stages, the first stage is 60%alcohol in the presence of propylene glycol in the amount of 1% at a ratio of 1:2 and 50° for 5 h, the second stage is 60%alcohol at a ratio of 1:2 for 15 h, the extracts are combined and filtered.
SUBSTANCE: invention concerns compounds of general formula (I), where: A represents O, CH2, S, SO or SO2; X and Y are chosen from Br, Cl and -CN3; R1 is chosen from the group consisting of -(CH2)nCOOH, -NHC(=O)COOH, -NHCH2COOH, ;
Z represents H or -C=H; R2 is lower alkyl; R3 - H or lower alkyl; n means 1, 2 or 3; p means 1 or 2; or to their pharmaceutically acceptable salts or esters. Besides the invention covers a pharmaceutical composition based on said compounds expressing an agonist activity in relation to thyroid hormone receptor.
EFFECT: said compounds and pharmaceutical compositions containing thereof there can be effective for treatment of such diseases as obesity, hyperlipidemia, hypercholesterolemia and diabetes, and the other similar conditions and diseases, and can be used for treatment of the other diseases, such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and the other similar conditions and diseases.
25 cl, 1 tbl, 27 ex
SUBSTANCE: invention relates to a chemico-pharmaceutical industry, and concerns the solid pharmaceutical composition containing water-soluble salts of levothyroxine and-or liothyroninum as an active substance where water activity is set equal to less than 0.4 at measurement at a room temperature. The composition with 0.4 water activity or less possesses high stability at storage.
EFFECT: development of a composition which possesses high stability at storage.
18 cl, 4 ex
SUBSTANCE: invention relates to pediatrics and endocrinology and can be used for taking preventive measures aimed at treatment of thyroid gland diseases in children of early age born from mothers with opportunistic infections. Molecular-biological investigation of biological material is carried out by PCR method in order to indicate CMV and herpes infection. Immunoferment child's blood test is carried out with determination of IgM and IgG level. Also ultrasound examination of mother's and child's thyroid gland is performed, by results of diagnostics drug therapy is carried out in two stages. At first stage starting with twentieth week of pregnancy pregnant women are administered preventive therapy with iodine preparations: "iodomarin - 200" 200 mkg/day, "potassium iodide - 200" 200 mkg/day and vitamin-mineral complexes (VMC): "materna", "elevit", "folic acid". At second stage combined therapy is carried out in children with anti-viral medications famvir 0.25 in dose 10 mg/kg a day during 7-10 days, acyclovir 0.2 in dose 10 mg/kg a day during 10-14 days and viferon-1 in dose 150000 units 2 times a day during one month. Mothers in lactation period are administered therapy similar to preventive therapy.
EFFECT: ensuring increase of efficiency of thyroid gland treatment in children of early age.
SUBSTANCE: method concerns medicine, namely to endocrinology, and concerns treatments of a diffusive euthyroid struma. For this purpose the complex therapy including Iodidum of potassium is carried out - in a dose of 200 mkg/day, sodium selenate - in a dose - 150 mkg/day and Rekicene RD in a dose 10 g 3 times a day.
EFFECT: such complex of medicamental therapy provides effective pathogenetic treatment at the expense of a restore of deficiency of necessary trace substances in a combination to a selective sorption of salts of serious metals, arsenic and other potential goitrogens.
4 tbl, 1 ex
FIELD: medicine; endocrinology.
SUBSTANCE: lowered caloric content diet #5 is prescribed, in combination with fasting days 2 times a week with caloricity of 1000-1200 kilocalorie per day. Therapeutic physical training with individual exercise dosage is carried out daily in the first half the day for 30-40 minutes, within 21-24 days. The general manual massage is alternated by days with Charcot's douche, during the course of 8-10 procedures. A Charcot's douche effects the back thigh surface , buttocks, frontal abdominal wall - clockwise at pressure of 1.5-2 atmospheres, water temperature of 36°C, 0.5-1 minute per zone, total effect time is 4 minutes. The procedure is caried out in the second half of the day, in the course of 10-12 procedures. Electrosleep is carried out by oculo-cervical method at frequency of 10-20 Hz, current intensity up to 1-2 mA, exposure time is 30 minutes. Besides the procedure is carried out in the middle of the day, daily, in the course of 10-15 procedures. Group and individual appointments with the psychologist are carried out on the daily basis, during 45-60 minutes, within 21-24 days. Patients with combination of obesity and struma in addition are provided with iodide-bromine baths with iodine concentration of 10 mg/l, Bromum of 25 mg/l, water temperature is 37°C, procedure duration is 8-10 minutes, alternating by days with Charcot's douche, in the course of 8-10 procedures. The general massage is carried out at the same day with iodide-bromine baths, iodbalance intake is 100-200 mkg/per day, daily, after meal. In case of psychocorection additional activities are done for formation of motivation, loss of weight and long-term iodine drugs intake, reduction of anxiety, aggression and increase of self-appraisal.
EFFECT: body weight reduction, normalisation of arterial pressure, increase of exercise tolerance, correction of metabolic, hormonal and vegetative status parameters.
7 tbl, 2 ex
FIELD: chemistry, pharmacology.
SUBSTANCE: compound of formula [I]: is described, where the ring A represents halogen substituted benzene ring; the ring B represents benzene ring substituted with two lower, 1 to 4 carbon atoms, alcoxy-groups; the ring C represents benzene ring or five-member aromatic heterocyclic ring, that may be optionally substituted with substitute as follows: carboxyl group, C1-4-alkyl group, C2-7-alkanoiloxy-C1-6-alkyl group, phenyl-C1-4-alkyl group, phenyl group, optionally substituted with carboxyl group, or oxo-group; R1 represents C1-6-alkyl group, optionally substituted with hydroxyl group, that optionally substituted with C2-20-alkanoil or C1-7-alkyl group; X1a represents bound or C1-6-alkylen, optionally substituted with hydroxyl or oxo-group; X1b represents bound or C1-6-alkylen, optionally substituted with hydroxyl or oxo-group; X2 represents bound, -O- or -S- ; X3 represents bound or group, formed by one hydrogen atom elimination from either straight or branched chain C1-7-alkyl, or C2-6-alkenyl group, that optionally substituted with hydroxyl or oxo-group; and Y represents optionally etherified carboxyl group; or its salt. Benzoxazepin derivatives production method, medicine based on them, and their application are also described.
EFFECT: novel compounds have high lipids-decreasing effect and are helpful as hyperlipidemia prevention and treatment medicine.
20 cl, 168 ex
SUBSTANCE: invention concerns medicine, endocrinology. Perform insertion of an extract of dry roots of dropwort on 5 ml 3 times a day for 20 mines before meals. Course of treatment takes 20 days. Perform from 1 to 4 courses.
EFFECT: decrease of frequency and volume of operative measures.
2 cl, 5 ex
SUBSTANCE: method involves carrying out balneotherapy, foing physiotherapy exercises and intaking iodomarine and/or L-tiroksin. In first half of the day, physiotherapy exercises are performed, general artificial radon baths being performed in the second half of the day. Manual massages of a collar zone are perform in days free from baths. From November till March phonophoresis of Traumel S ointment on a thyroid gland projection is also performed with an intensity of 0.05 W/cm2, continuous regimen, duration of influence of 3-5 minutes on the right and at the left, general time of influence of 6-10 minutes, in a day with a magnetotherapy on a projection of palatine tonsils, size of a magnetic induction being 6-9 mT, for 5-6 minutes from each party, general time of 10-12 minutes, in a course of 8-10 procedures. At treatment during the period from April till October, patients are additionally prescribed a group galotherapy in the second half of the day, in a course of 10-15 procedures, and phototherapy of red range at a wavelength of 660-675 nanometers, densities of power of radiation of 1 mW/cm2 and an infra-red range at a wavelength of 840-950 nanometers, densities of power of radiation of 2.7 mW/cm2 to biologically active points: VC-20, VC-22, E-36 symmetrically on the right and the left, Gi-4 symmetrically on the right and the left. Time of influence for one point is 1.5-2 minutes, general time of influence being 9-12 minutes, daily, in 10-12 procedures, with duration of treatment making up 21-24 days.
EFFECT: decrease of exacerbations of chronic centres infection frequency; normalising action on the immunologic status during the most adverse periods of a year and maintenance of a condition of euthyroidism within all year.
3 tbl, 2 ex
SUBSTANCE: invention can be used for medical treatment of secondary hypothyroid state accompanied by low synthesis of thyrotrophic hormone by hypophysis and of iodine hormone by thyroid gland. Substance of invention implies application of peptide Lys-Glu-Asp-Gly as a medicine stimulating synthesis of thyrotrophic hormone by hypophysis and of thyroid hormone by thyroid gland.
EFFECT: high specific activity of introduced peptide and decrease of side effect risk.
4 tbl, 1 ex
FIELD: medicine, endocrinology, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to design of agent used in treatment of iodine-deficient diseases, in particular, hypothyroidism. Agent for treatment of hypothyroidism comprises the following medicinal plants: walnut green fruits, wormwood herb, warty birch buds, licorice roots and clove flower buds taken in the ratio = 30:2:10:2:2, respectively. Agent is prepared as tincture in 35% ethyl alcohol. Method for treatment of hypothyroidism involves prescription of abovementioned agent to a patient orally in the dose 7-30 drops, 3 times per a day, 15 min before eating with 50 ml of water for 5-35 days. In all cases treatment of patients with the proposed agent resulted to the stable therapeutic effect without adverse effects.
EFFECT: valuable medicinal properties of agent.
2 cl, 2 ex
SUBSTANCE: invention relates to field of medicine and concerns composition, which stimulates immune answer, containing nanoparticles, based on copolymer of methylvinyl ether of maleic anhydride. Mentioned nanoparticles can additionally contain allergen or antigen and/or immunostimulating agent, which can be inside of said nanoparticles and/or at least partially cover surface of mentioned nanoparticles and optionally crossing-linking agent. Composition, which stimulates immune response, can be applied as adjuvant in immunotherapy and vaccines.
EFFECT: increase of activity.
32 cl, 7 ex, 2 tbl, 13 dwg
SUBSTANCE: invention relates to field of medicine, in particular to pharmaceutics, and concerns pharmaceutical compositions, which contain as active substance therapeutically effective quantity of ladasten, and as target additives - starch, stearic acid and/or its salt or ludipress and stearic acid and/or its salt with definite ratio of said components. Composition is made in form of pills, contains optimal quantity of target additives, which allows to obtain easy swallowed pills. Pills meet all requirements of State Pharmacopoeia XI edition.
EFFECT: medication form easily releases active substance, which provides its high bioaccessibility.
13 cl, 1 tbl, 5 ex
SUBSTANCE: invention relates to virology, immunology and medicine. The composition contains antigen bound or fused with virus-like particle (VLP), completed with immunostimulating nucleic acid containing at least one unmathylated CpG-sequence and ligand of toll-like receptor (TLR). There are also disclosed vaccine composition and method for potentiating immune response in an animal.
EFFECT: invention can be used for inducing strong antibody and T-cell response and, particularly it is effective in treatment of allergy, tumours and virus chronic diseases, and also other chronic diseases.
25 cl, 12 dwg, 1 tbl, 11 ex
SUBSTANCE: invention refers to medical products and concerns an ellagic acid composition for immune system enhancement, differing that additionally is contains chitosan beta-1.3/1.6-glucans or oligosaccharides.
EFFECT: offered composition possesses enhanced immunostimulating effect.
SUBSTANCE: invention refers to pharmacology and can be used in veterinary science and medicine for chemotherapy. There is disclosed immunostimulating and antioxidant lithium composition containing lithium ascorbate and lithium aspartate in percentage ratio 50:50.
EFFECT: expansion of the list of low-toxicity immunomodulators applicable for manufacture of drugs.
1 dwg, 2 tbl
SUBSTANCE: invention concerns medicine, particularly therapy, and can be applied in chronic disease treatment. Method involves causative agent extraction or determination of antibodies to causative agents or extraction of genetic components from blood, body fluid or smear. Treatment is performed by vaccine drugs specific to one or several identified causative agents, additionally immunomodulators are administered.
EFFECT: activated repair processes, arrested development of disease state of organs and systems due to elimination of identified pathogen from organism and to immune correction.
3 cl, 8 ex
SUBSTANCE: invention concerns medicine, particularly granulocytopoiesis stimulants, radioprotectors and immune stimulants. Under cytostatics effect Cyclophilin A amplifies granulocyte precursor removal from marrowbone and stimulates granulocytopoiesis.
EFFECT: in case of sublethal radiation, cyclophilin A stimulates migration of marrowbone stem elements and participates in recovery of blood cells and immune system, and shows redioprotection properties.
4 dwg, 2 tbl
SUBSTANCE: medicinal agent contains alpha and/or beta and/or gamma human recombinant interferon, tocopherol acetate or other tocopherol derivatives, ascorbic acid and/or its salts, pantothenic acid or calcium pantothenate, or dexapanthenol, riboflavin or levocarnitine, and orotic acid and/or ornithine or its derivative - citrulline malate, or Glutoxim, antibacterial, antimycotic agents, additives: emulsifiers, stabilisers, preservatives, antioxidants and base. The formulation is suppositories in certain component ratio.
EFFECT: efficiency for severe infectious diseases and mixed infections.
9 cl, 18 ex
SUBSTANCE: invention concerns medicine, be more specific to oncology, and concerns the substances stimulating maturing of dendritic cells (DC). Application of fucoidan from Fucus evanescens or polysaccharide composition from Fucus evanescens consisting of fucoidan in amount of 60-80% and poly-mannuronic acid in amount of 20-40%, as an agent possessing ability to induce maturing of dendritic cells is offered. The declared fucoidan preparations have a standardised composition and, hence, possess direct biological effect. They keep the properties for long time (3 years).
EFFECT: increase of DC functional activity under the influence of the declared substances.
FIELD: medicine, veterinary science.
SUBSTANCE: invention concerns veterinary science, in particular, to ways of reception of immunomodulatory and antiseptic compounds for prevention and treatment of infectious diseases of animals. The way of reception of a complex immunotropic antiseptic preparation for prevention and treatment of infectious diseases of animals includes mixing of an amber acid, novocaine, Dorogov's antiseptic-stimulator of the second fraction and formalin in water at a following parity of components, wt %: amber acid 1; DAS №2 4; novocaine 0.25; formalin 0.4; the distilled water - the rest, and sterilisation using autoclave treatment which is performed in a 1 atm regimen. Within 20 minutes. The received compound possesses antiseptic, immunomodulatory and trophicostimulating activity at a parenteral way of introduction.
EFFECT: rising of efficiency of the received preparation at treatment and prevention of infectious diseases of animals.
SUBSTANCE: algae Gracilaria verrucoza are incubated in distilled water in order to transform unsaturated fatty acids under influence of present in alga enzymes into prostaglandins. Prostaglandins are transferred into distilled water. Extraction of prostaglandins from water solution by sorption with further eluting with water-organic solvents is carried out. Freshly collected alga is used, incubation is carried out during 1-3 hours with light illumination with intensity 100-300 mcE/m2s and temperature not higher than 4°C, before extraction of prostaglandins by sorption obtained water solution is acidified to pH 2.5-3.0, as sorbent non-polar modified silicagel with graft hydrocarbons with grain size to 100 mcm.
EFFECT: increase of product yield and process simplification.