Method of diagnosing hyper- and hypo- function of thyroid gland

FIELD: medicine.

SUBSTANCE: invention relates to medicine, endocrinology, pathophysiology and biology. For diagnostics of hyper- and hypo- function of thyroid gland physical method of examination is used. Glass plate, on which preliminarily in form of path applied is 1% water solution of asparaginic aminoacid (1% WSAA) in volume 0.03-0.05 ml, is placed on neck skin surface in zone of thyroid gland projection. Plate is kept on neck surface in zone of thyroid gland projection during 3-5 minutes. Preparation is dried in thermostat at T= +18-20°C during 2-3 minutes, after that is examined in polarised light with quartz compensator. If in preparation crystals - small plumose with separate rhombic inclusions- are present, hyperfunction of thyroid gland is registered. If only rhombic inclusions are present, hypofunction of thyroid gland is diagnosed.

EFFECT: method is simple in realisation, highly-informative, reduces examination time and financial costs.

10 dwg, 6 ex

 

The present invention relates to medicine, namely to endocrinology, pathophysiology, biology, and can be used to diagnose hyperthyroidism (thyrotoxicosis) and hypofunction (hypothyroidism) of thyroid gland.

The thyroid gland (thyroid) - an endocrine organ. Produced by it of thyroid hormones - thyroxine (T4) and triiodothyronine (T3) possess high biological activity, regulate all kinds of exchanges, the synthesis of DNA, RNA, cell membrane permeability, tissue respiration.

When overactive thyroid gland develops hyperthyroidism, characterized by persistent pathological increase in production of thyroid hormones. Excess hormones causes a disturbance in the functioning of most organs and body systems.

An underactive thyroid slows down the flow of metabolic processes, the accumulation in the tissues of mucopolysaccharides, electrolyte imbalance.

Among the methods of laboratory diagnosis of thyrotoxicosis (hyperthyroidism and hypothyroidism emphasis on hormonal study. This determines the levels of T3, T4 and thyroid stimulating hormone (TSH).

Key hormonal markers in the diagnosis are free thyroxine (SWT) and TSH. Concentration SWT is held in equilibrium by the mechanisms of regulation of the hypothalamic-pituitary-thyroid system and b the atmospheric possibilities of linking tyrosinaemia globulin, albumin and prealbumin. Therefore, the concentration SWT not depends on the content tyrosinaemia globulin. Change SVT is an objective criterion for evaluating the function of the thyroid gland.

Known immunodeficiency way to determine thyroid hormones. The method is based on the use of labeled antibodies. Due to its high specificity and sensitivity, provide monoclonal antibodies, can in-vitro to detect the presence of biological fluids of many substances (hormones, enzymes, tumor markers and so on). This category of methods include radioimmunoassay (RIA), enzyme-linked immunosorbent (ELISA) and immunofluorescence named because of the components and nature of the label. (Wood S.Y., Sokolovsky, Theory and practice radioimmunoassay. Guidance for staff laboratory services. "Globus", Vienna, 1981; Reznikov A.G. Methods for the determination of hormones "Naukova Dumka", Kiev, 1990.)

Similar radioimmunoassay method, the fundamental principle of which is the competitive interaction of molecules of the hormone and specific antibodies or other associated proteins.

In the basis of the method is the use as a label radioactive isotope (wood S.Y., Sokolovsky, Theory and practice radioimmunoassay. Guidance for staff laboratory services. "Globus", Vienna, 1981).

The main this is s how:

- preparation of samples,

- the use of radioactive isotope,

- the use of a gamma counter.

The disadvantages of the method:

- irradiation,

- the use of a gamma counter,

- the high cost of equipment.

The closest analogue - immunoassay method for determination of free thyroxine in serum, plasma of human blood (application instruction set of reagents for qualitative assay of free thyroxine in serum, plasma. Registration Committee the public health Ministry. R/C No. 2000/93 from 06.04.2000. Set{FT4 EIA COBAS CORE. ARTICLE ELISA COBAS CORE}" Cat. No. 2051915/20736015, S508062).

The essence of the immunoassay method lies in the fact that the protein hormone ligand mark is not radioactive isotope, enzyme, in particular peroxidase from horseradish.

Peroxidase activity and, therefore, the content of conjugated to her hormone is measured by a photometric method using hydrogen peroxide as a substrate.

The implementing method.

THE SEQUENCE OF STATEMENT ANALYSIS MANUAL METHOD ARTICLE ELISA COBAS CORE.

Bring all reagents to room temperature before use shake). Prepare tubes in duplicates (+1 for background samples).

I incubation

Contributed reagents: 20 ál calibrator (3), or 20 ál control sera (4), or 20 μl of patient sample and 250 ál analytical b is Fehr (5).

Add 1 ball. Carefully mix. Incubated for 30 minutes at 37°C with constant shaking. Washed in the washer Roche for a given program.

II incubation

Make 200 ál cold conjugate (2).

Incubated for 15 minutes in the refrigerator at 4-8°C without shaking. Washed in the washer for a given program. Prepare working substrate solution for 10 minutes before use rate of 1 volume of substrate solution TMB (8)+4 amount of substrate buffer H2O2(10).

Add 250 μl of working substrate solution. Carefully mix. Incubate 15 minutes at 37°C With constant shaking.

Add 2 ml of sulfuric acid (12). Carefully mix. Measure the absorbance at 450 nm against the OP, calculate the concentration ST4 using the ELA program on your computer.

The disadvantages of the method:

1. The specificity of the samples is not absolute. It is possible that the cross-reacting substance can falsify the results.

2. Immunodeficiency analysis is a complex study that require high skills and a thorough implementation of all procedures. Any small technical mistake due to the extremely high sensitivity of the tests and very low concentrations of detected substances leads to a distortion of the final result.

3. The high cost.

Tasks pre the proposed invention.

1. Ensuring rapid diagnosis function thyroid - Hyper-and hypofunction.

2. Raising awareness of diagnosis.

3. Reducing logistical costs.

For the development of the present invention used the opportunity of registration of bio-energy radiation of living objects (in this case the thyroid gland).

It is known that a living object in all directions radiate the modulated electromagnetic radiation. Appear complex information encoded multifrequency patterns of oscillations, individual information and energy codes (Electromagnetic field in the biosphere. T.1, 2. - M - 1984; Gulyaev YU.V., Year EE Physical fields of biological objects. In the book: Cybernetics of living. Biology and information - M - 1984 - P.39-60; Ananin SCI Bioenergy man - M - 1993).

Functioning cell is the source and carrier of complicated radiation, the cell structure may vary depending on the nature and frequency of the rhythm of radiation caused by the course of metabolic processes in the cell itself (Vpiznaju, Lpereira. Bioinformation function of natural electromagnetic fields. Novosibirsk, 1985).

The structure is a snapshot of the internal energy of interactions in a biological system (A.A. Malinovsky. Theory of structures and its place in the system approach. - M., 1970 - P.10-31).

When the excess or lack of thyroid hormones, first of all, affects the metabolism of amino acids, thyrotoxicosis at the beginning of the disease, their number increases (glutamic, aspartic, and others), hypothyroidism slows down protein synthesis and decreases the number of amino acids (L.V. Borodin Secretion of certain hormones and their influence on the amino acid composition of blood thyrotoxicosis and hypothyroidism. Auth. Kida. dis. M., 1982). The metabolism of amino acids is also reflected in the intensity of the progress energy metabolism in the thyroid gland, and hence on the structure of the body (hyperplasia, degeneration).

The technical novelty of the proposal is a physical method to study the function of the thyroid gland, characterized in that on the surface of the neck in the area of projection of the thyroid gland is placed a glass plate, on which the tracks are 1% aqueous solution of aspartic amino acids (1% VRAA) displacement of 0.03-0.05 ml, incubated the plate on the surface of the body for 3-5 minutes, the product is dried in a thermostat at T=+18-20°C for 2-3 minutes, then examined under polarized light with a quartz compensator and in the presence of drug crystals - small pinnate with separate rhombic inclusions diagnosed with hyperactive thyroid cancer, and if there is only a rhombic inclusions - the hypofunction of the thyroid gland.

The advantages of the proposed method. For iagnostic Hyper - and hypofunction of the thyroid gland applied 1% solution of aspartic amino acids, which registers the biological radiation gland.

Microscopic examination of the drug becomes possible to assess the functional status of thyroid - Hypo - or hyperfunction. The method provides high information content, the efficiency of diagnosis. Observed the native characteristics of bacterial physiology and fashion. Compared with the basic methods of diagnostics of thyroid function research time reduced by 75%and material costs by 80-85%.

The method is as follows:

1. Prepare a 1% aqueous solution of aspartic amino acids (1% URAA).

2. Calibrated pipette 1% VRAA applied on the glass plate in the form of a thin film soundtracks, the volume of liquid 0,03-0,05 ml

3. Glass plate coated with 1% VRAA placed on the study area of the skin in the area of the projection of the thyroid gland (lobe, isthmus), stand on the surface of the projection zones of the body for 3-5 minutes.

4. The product is dried in a thermostat at T=+18-20°C for 2-3 minutes.

5. The sample examined in polarized light with a quartz compensator.

6. In the presence of drug crystals - small pinnate with separate rhombic inclusions register hyperfunction of the thyroid gland, with only rhombic inclusions - hypofunction.

Here is the structure dried 1% aqueous solution of aspartic amino acids, 1, cu are present the large and small grains, presents mainly orthorhombic form.

Figure 2 shows a typical structure 1% VRAA obtained when placing a glass plate coated with 1% VRAA on the area of projection of the thyroid of a healthy person. Visible large feathery crystals with a single rhombic turning.

Conducted 217 clinical studies.

Examples.

Example 1, 3, 4. Investigated the function of the thyroid gland of the patient K. Diagnosis (DS): Diffuse toxic goiter, the average degree of gravity, first identified. History (IB) No. 4812. Figure 3, 4 shows the small feathery crystals with rhombic inclusions.

Technology. The glass plate is caused to 0.03 ml of 1% VRAA in the form of tracks. The plate was placed on the surface of the neck in the area of the projection of the thyroid gland and stand for 5 minutes. Then was dried in a thermostat at T=+18°C for 3 minutes and examined under polarized light with a quartz component (CC). There are small feathery crystals with separate rhombic inclusions. At the same time in the UK the patient will determine the content of the Holy T4, it was increased to 29 pmol/l (norm - 16,1±0.18 pmol/l). Diagnosis: hyperthyroidism (thyrotoxicosis) has confirmed.

Example 2, 5, 6. Researched thyroid patient U. DS: Mixed toxic goiter, first identified. IB No. 4951. Figure 5, 6 shown small feathery crystals with rhombic inclusions.

T is hnology. The glass plate is caused to 0.04 ml of 1% VRAA in track and placed on the surface of the neck in the area of projection of the thyroid gland. The plate has stood for 4 minutes, then dried at T=+19°C for 3 minutes and examined under polarized light with a quartz component. Visible small feathery crystals with separate rhombic inclusions. At the same time in the UK the patient will determine the content of the Holy T4, it was a high - 34.5 pmol/L. the Diagnosis of hyperthyroidism the thyroid gland was confirmed.

Example 3, Fig.7. Researched thyroid patient, DS: Diffuse toxic goiter, first identified. IB No. 695. Figure 7 shows the small feathery crystals with rhombic inclusions.

Technology. The glass plate caused 0.05 ml 1% VRAA in the form of tracks. The plate was placed on the surface of the neck in the area of the projection of the thyroid gland, has stood for 5 minutes, then dried at T=+20°C for 2 minutes and examined under polarized light with QC. Visible small feathery crystals with separate rhombic inclusions. At the same time in the UK the patient will determine the content of the Holy T4, it was a high - 43,0 pmol/L. the Diagnosis of hyperthyroidism the thyroid gland was confirmed.

Example 4, Fig. We investigated the function of the thyroid gland patient F. DS: Nodular goiter I, hypothyroidism revealed for the first time. IB No. 349. On Fig are only rhombic crystalline inclusions.

Technology. On stekljannoe the plate caused 0.05 ml 1% VRAA in the form of tracks. The plate was placed on the surface of the neck in the area of the projection of the thyroid gland, has stood for 5 minutes, the product was dried at T=+20°C for 3 minutes. Examined the sample under polarized light with QC. In the field of view there are only rhombic crystalline inclusions. At the same time in the UK the patient will determine the content of the Holy T4, it was reduced to 10.2 pmol/l, the rate is 16.1±0.18 pmol/L. Diagnosis of hypofunction of the thyroid gland was confirmed.

Example 5, figure 9. We investigated the function of the thyroid gland patient W. DS: Postoperative hypothyroidism, first identified. IB No. 7918. Figure 9 shows a rhombic crystalline inclusions.

Technology. The glass plate is caused to 0.04 ml of 1% VRAA in the form of tracks. The plate was placed in an area of projection of the thyroid gland, held for 4 minutes, then dried at T=+19°C. microscopic examination under polarized light with QC found only crystalline orthorhombic inclusion. Simultaneously in the UK the patient is determined to St. T4, which was reduced to 7.2 pmol/L. Diagnosis of hypofunction of the thyroid gland was confirmed.

Example 6, figure 10. We investigated the function of the thyroid gland patient J. DS: Autoimmune thyroiditis, hypothyroidism, first identified. IB No. 6152. Figure 10 shows a rhombic crystalline inclusions.

Technology. The glass plate is caused to 0.03 ml of 1% VRAA in the form of tracks, was placed in the area of the projection of the thyroid gland, held it for 3 minutes, the product was dried at T=+18°C and subjected to microscopy the AI in polarized light with QC. In the field of view there are only rhombic crystalline inclusions. Simultaneously in the UK the patient is determined to St. T4, which was reduced to 9.0 pmol/L. Diagnosis: thyroid hypofunction has confirmed.

Method for the diagnosis of Hyper - and hypofunction of the thyroid gland, including physical research method, characterized in that the surface of the skin in the area of projection of the thyroid gland is placed a glass plate, on which the tracks are 1%aqueous solution of aspartic amino acids (1% VRAA) displacement of 0.03-0.05 ml, incubated the plate on the surface of the neck in the area of projection of the thyroid gland during 3-5 min, the product is dried in a thermostat at T=18-20°C for 2-3 min, then examined under polarized light with a quartz compensator and in the presence of drug crystals - small pinnate with separate rhombic inclusions diagnosed with hyperthyroidism, if there is only a rhombic inclusions - the hypofunction of the thyroid gland.



 

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