Means for dyeing keratin-containing fibres

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, specifically to an agent for dyeing keratin-containing fibres, first of all, human hairs, containing at least one compound of formula (I) and/or its enamic form, with R meaning allylic group, hydroxyalkyl group with 2-6 carbon atoms, or if required, substituted benzyl group, X- meaning a physiologically acceptable anion, and at least one aldehyde.

EFFECT: invention allows producing dyeing with shine, improved washability and light resistance.

18 cl, 3 ex, 3 tbl

 

The present invention relates to a means for containing coloring keratin fibers, especially human hair, containing substituted in position 1 special derivatives of 1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine in combination with selected aldehydes as reactive carbonyl compounds, to the use of such combinations in the means for containing coloring keratin fibers, color restore, respectively, the nuance is already painted with the keratin fibers and to a method of dyeing containing keratin fibers, especially human hair.

For staining containing keratin fibers in the General case, use either the direct dyes or oxidation dyes, which are formed in the oxidation of a combination of one or more developing components with each other or with one or more actual pigment components. The actual pigment and showing components also referred to as initial products for oxidative dyes.

As showing components typically use primary aromatic amines with para - or ortho-position additional unsubstituted or substituted hydroxyl or amino group, derivatives diaminopyridine, heterocyclic hydrazones derived 4-aminopyrazole is a, as well as 2,4,5,6-tetraaminopyrimidine and its derivatives.

Special representatives of the exhibiting components are, for example, p-phenylenediamine, p-toluylenediamine, 2,4,5,6-tetraaminopyrimidine, p-aminophenol, N,N-bis(2-hydroxyethyl)-p-phenylenediamine, 2-(2,5-diaminophenyl)ethanol, 2-(2,5-diaminophenoxy)ethanol, 1-phenyl-3-carboxamido-4-aminopyrazole-5-Oh, 4-amino-3-METHYLPHENOL, 2-amino-methyl-4-aminophenol, 2-hydroxymethyl-4-aminophenol, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopirimidina and 2,5,6-triamino-4-hydroxypyrimidine.

As the actual pigment components, typically use derivatives of m-phenylenediamine, naftaly, resorcinol or its derivatives, pyrazolones and m-aminophenols and substituted derivatives of pyridine. Fit the actual pigment components are primarily α-naphthol, 1,5-dihydroxynaphthalene, 2,7-dihydroxynaphthalene and 1.7-dihydroxynaphthalene, 5-amino-2-METHYLPHENOL, m-aminophenol, resorcinol, simple onomatology ether of resorcinol, m-phenylenediamine, 2,4-diaminophenoxyethanol, 2-amino-4-(2-hydroxyethylamino)anisole (blue Lehmann), 1-phenyl-3-methylpyrazole-5-he, 2,4-dichloro-3-aminophenol, 1,3-bis(2,4-diaminophenoxy)propane, 2-chlororesorcinol, 4-chlororesorcinol, 2-chloro-6-methyl-3-aminophenol, 2-methylresorcinol, 5-methylresorcinol, 3-amino-6-methoxy-2-methylaminopropane and 3,5-diamino-2,6-dimethoxypyridine.

Information about the component is in commonly used dyes contained in the released Ch. Culnan, H. Maibach series "Dermatology", publisher Marcel Dekker Inc., New York, Basel, 1986, vol 7; Ch. Zviak, The Science of Hair Care, Chapter 7, pages 248-250 ("Direct dyes"), Chapter 8, pages 264-267 ("Oxidation dyes"), and published by the European Commission the list of "Europäische Inventar der Kosmetikrohstoffe", 1996, which may be granted in writing on the diskette by the Federal Association of German industrial and trading enterprises on medicinal substances and products for a balanced diet and hygiene, Mannheim.

Although oxidative dyes and allow you to get an intense color with high resistance, however, the manifestation of color in the General case occurs under the action of oxidizing agents such as hydrogen peroxide, which in some cases can cause damage to the fibers. Still, an important issue is of sufficient strength hair coloring in the red range, achieved by using oxidation dyes, especially as regards the possibility of providing very high resistance to washing and strength, wear. In addition, some of the initial products of oxidation dyes, respectively, some mixtures of such products, in some cases, can have a sensitizing effect on people with sensitive skin. Direct dyes are used in a gentle manner, but they are not who headed the remainder of the is that obtained with the use of color often have low resistance parameters.

In article Nvamp and others, Liebigs Ann. Chem., 1968, 124-136, describes the reactions of pyrimidine as methylene bases. However, the tool for dyeing hair containing derivatives of 1,2-dihydro-2-oxopyrimidine, or application described in this publication hemocyanine for dyeing containing keratin fibers in this publication are not available.

In the German patent application DE-A1-2047431 considered cationic methine dyes intended for dyeing anionic modified fibers, such as fibers of acid-modified polyesters or polymers of Acrylonitrile. To obtain such cationic marinovich dyes are used, in particular, 3,4-dihydro-3-methyl-4-methylthiazole-2-he and 1,3,6-trimethyl-4-methyleneimine-2-it, and optionally terephthalic aldehyde.

In the German patent application DE-A1-2165913 proposes a method of obtaining coloring agents, which involves the use of photosensitive dyes. The inventive photosensitive dyes belong to the class pyrimidinone, respectively dipyrimidine dyes.

In the German patent application DE-A1-10241076 for use as a means for coloring keratin ox is con offers derivatives of 1,2-dihydro-2-oxopyrimidine in combination with reactive carbonyl compounds. However, such tools need to be improved, the purpose of which is to enhance the resistance obtained with the use of colors, especially light fastness and resistance to washing.

From German patent application DE-A1-2165913 it is known that dyes based pyrimidone have sensitivity. Although in the German patent application DE-A1-10241076 and it was found that these dyes for dyeing hair well suited in terms of light fastness, however, it is this parameter that needs optimization. Thus, the present invention was based on the task to provide means for containing coloring keratin fibers, especially human hair, which intensity they were creating the painting, the overlap of the gray tones and indicators durability such as light resistance, abrasion resistance and resistance to washing and resistance to sweat and perming, primarily for resistance to washing and light fastness, qualitatively superior to the dyes according to the German patent application DE-A1-10241076. In addition, the dyes should not have a sensitizing effect, or it must be very small.

It has been unexpectedly found that the compounds of formula (I) in combination with the selected derivatives of aldehyde perfectly suitable for okresu the deposits containing keratin fibers, carried out in the presence of oxidizing agents. Created painting have excellent brilliance, intensity and variety of colour shades. Painting received and without oxidizing agents, are characterized primarily by increased resistance to washing, light fastness and a wide range of possible color shades from yellow to yellow-brown, orange, brown-orange, brown, red and reddish purple to bluish-purple, blue and black. However, the possibility of using the oxidizing agent in this case should not be excluded.

The first object of the present invention is a means for containing coloring keratin fibers, especially human hair, containing, as component a at least one compound of formula (I)

and/or its enaminone form

and

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,

X-means physiologically acceptable anion,

and as a component in at least one aldehyde selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxy-benzaldehyde,3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxy-benzaldehyde, 3,5-dibromo-4 hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methyl-benzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde.

Examples of the hydroxyalkyl group with 2-6 carbon atoms in the compounds of formula (I) are 2-hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl, 4-hydroxybutyl and 6-hydroxyhexyl. Preferred hydroxyalkyl groups with 2 to 6 carbon atoms in the compounds of formula (I) are 2-hydroxyethyl, 2-hydroxypropyl and 3-hydroxypropyl, particularly preferred 2-hydroxypropyl and 3-hydroxypropyl.

The remainder R in the compounds of formula (I) preferably means allyl, 3-hydroxypropyl, 2-hydroxypropyl, 2-hydroxyethylene or benzyl group.

The counterion X-in the compounds of formula (I) is preferably selected from the group comprising halide, bansilalpet, p-toluensulfonate, alkanesulfonyl with 1-4 carbon atoms, triftorbyenzola, perchlorate, 0.5 sulfate, hydrosulfate, tetrafluoroborate, hexaphosphate or tetrachlorozincate. The counterion X-particularly preferably denotes chloride, bromide or hydrosulfate.

Numbering forming compounds, atoms shown on p is the iMER following compounds of formula (II-1).

The compounds of formula (I) preferably chosen from the group comprising physiologically acceptable salts of 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxo-pyrimidine, 1,2-dihydro-1-(3-hydroxypropyl)-3,4,6-trimethyl-2-oxo-pyrimidine and 1-benzyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine and

enaminone form 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(3-hydroxypropyl)-3,4,6-trimethyl-2-oxopyrimidine and 1-benzyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine.

Present in the above salt counterion, preferably selected from the group comprising halide, bansilalpet, p-toluensulfonate, alkanesulfonyl with 1-4 carbon atoms, triftorbyenzola, perchlorate, 0.5 sulfate, vodoroslevyh, tetrafluoroborate, hexaphosphate and tetrachlorozincate, especially bromide, chloride, vodoroslevyh and p-toluensulfonate.

Especially preferred compounds of formula (I) is chosen from the group comprising compounds of the formulas (II-1)to(II-12), namely, bromides, chlorides or hydrosulfate 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(3-hydroxypropyl)-3,4,6-trimethyl-2-oxo-pyrimidine and 1-benzyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine and enamino the diversified forms of these compounds. The following structure is particularly preferred compounds of the formulas (II-1)to(II-12):

Under the CH-acidic compounds in General involve compounds that contain attached to an aliphatic carbon atom, the hydrogen atom, and dilatory electrons substituents contribute to the activation of the corresponding carbon-hydrogen bonds. Proposed in the invention the compounds of formula (I) and formula (II-1)to(II-12) are CH-acidic compounds.

CH-acidic compound is in equilibrium with the corresponding enaminones form. Targeted receiving enamines of the compounds of the above formulas is possible due to implemented using the base deprotonation of the carbon atom of active methyl groups at position 4 or 6. The following is an example of such deprotonation. Compounds of formula (Ia), (Ib), are examples proposed in the invention enaminone forms of derivatives of 1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine the

Under containing keratin fibers include wool, fur, feathers and especially human hair. However, the proposed invention coloring means, in principle, can be used for coloring natural fibers, such as fibers of cotton, jute, sisal, linen or silk, as well as modified natural fibers, such as fibers of regenerated cellulose, nitrocellulose, alkylaryl or hydroxyethylcellulose or acetate.

Derivatives of 1,2-dihydro-2-oxopyrimidine in General are known from the literature or are commercially available products. Proposed in the invention the compounds of formula (I) are novel substances, but they can be synthesized by the known methods described in D.Lioyd and others, J.Chem. Soc. Perkin Trans I, 1977, 16, 1862-1869; S.T.Oswald and others, J. Heterocycl. Chem., 1974, 11(3), 441-443; H.Baumann and others, Liebigs Ann. Chem., 1968, 717, 124-136 and V.A.Chuiguk, Ukr. Khim. Zh. (Russ. Ed), 1982, 48(11), 1220-1223.

According to the second option proposed in the invention coloring tools to expand the color palette may be preferable to add to the components already contained in such Crusades tool, then there is at least one compound of formula (I)used as component a and at least one other connected to the Yu, used as a component in at least one additional connection - component C. is Used as a component connection choose: a) CH-acidic compounds different from the compounds of formula (I), and/or (b) of reactive carbonyl compounds different from the compounds used as component C.

According to the invention reactive carbonyl compounds, used as an additional component, as reactive groups contain at least one carbonyl group, which interacts with CH-acidic compound of formula (I) with the formation of carbon-carbon linkages. In addition, according to the invention as component C can also be used compounds, reactive carbonyl group which is converted, respectively, is hidden, so that the carbon atom in the converted carbonyl group kept constant reactivity in relation to the CH-acidic compounds of formula (I). Derived from transformed in a similar way carbonyl group are preferably adducts, formed by joining the carbon atom convertible reactive carbonyl compounds

(a) amines and their derivatives (relevant and what products are imine or oximes),

b) alcohols (corresponding adducts are acetals or ketals),

c) water (corresponding adducts are hydrates) (in this case, the component is derived aldehyde ab).

CH-acidic compounds used as an additional component, preferably selected from the group comprising salts of 1,4-dimethylaniline, 1-ethyl-4-methylinosine, 1-ethyl-2-methylinosine, 1,2,3,3-tetramethyl-3H-indole, 2,3-dimethylbenzothiazole, 2,3-dimethyl-oil[1,2-d]thiazole, 3-ethyl-2-methylnaphtho[1,2-d]thiazole, 3-ethyl-2-methyl-benzoxazole, 1,2,3-trimethylhexane, 3-ethyl-2-methylbenzothiazole, 1,2-dihydro-1,3,4,6-tetramethyl-2-oxopyrimidine, 1,2-dihydro-1,3,4-tri-methyl-2-oxopyrimidine, 1,2-dihydro-4,6-dimethyl-1,3-dipropyl-2-oxo-pyrimidine, 1,2-dihydro-1,3,4,6-tetramethyl-2-dioxopyrimidine, 1,2-dihydro-1,3,4,5,6-pentamethyl-2-oxopyrimidine, 2,5-dimethyl-3-(2-propenyl)-1,3,4-thiadiazole, 3-ethyl-2,5-dimethyl-1,3,4-thiadiazole, 1,2-dimethyl-quinoline, 1,3 .3m-trimethyl-2-methyleneindoline (base Fisher), oxindole, 3-methyl-1-phenylpyrazole-5-she indan-1,2-dione, indan-1,3-dione, indan-1-it, 2-amino-4-imino-1,3-diazolidinylurea, benzoylacetonitrile, 3-dicyanomethylene-1-it, 2-(2-furanol)acetonitrile, 2-(2-thenoyl)acetonitrile, 2-(lanmeter)-benzimidazole, 2-(lanmeter)benzothiazole and 2-(2,5-dimethyl-3-furanol)acetonitrile formed with physiologically acceptable anions, before the e only p-toluensulfonate, methansulfonate, Bogorodchany, tetrafluoroborate and halides, such as chlorides, bromides and iodides.

Preferred additional reactive carbonyl compounds used as component C are selected from the group including benzaldehyde and its derivatives, naphthaldehyde and its derivatives, cinnamic aldehyde and its derivatives, 2,3,6,7-tetrahydro-1H,5H-benzo[ij]chinolin-9-carboxaldehyde, 2,3,6,7-tetrahydro-8-hydroxy-1H,5H-benzo[ij]chinolin-9-carboxaldehyde, N-ethylcarbazole-3-aldehyde, 2-formylmethylene-1,3 .3m-trimethylindolenine (aldehyde Fisher or rejonowy aldehyde), 2-incollege, 3-incollege, 1-methylindol-3-aldehyde, 2-methylindol-3-aldehyde, 2-(1',3',3'-trimethyl-2-indolinone)acetaldehyde, 1-methylpyrrole-2-aldehyde, 4-pyridinylmethyl, 2-pyridinylmethyl, 3-pyridinylmethyl, pyridoxal, antipyrine-4-aldehyde, furfural, 5-nitrofurfural, 2-thenoyltrifluoroacetone, chroman-3-aldehyde, 3-(5'-nitro-2'-furyl)acrolein, 3-(2'-furyl)acrolein, imidazole-2-aldehyde, 5-(4-dimethylaminophenyl)Penta-2,4-dienal, 5-(4-diethylaminophenyl)Penta-2,4-dienal, 5-(4-methoxyphenyl)Penta-2,4-dienal, 5-(3,4-acid)-2,4-dienal, 5-(2,4-acid)-2,4-dienal, 5-(4-piperidinophenyl)Penta-2,4-dienal, 5-(4-morpholinomethyl)Penta-2,4-dienal, 5-(4-pyrrolidinyl)Penta-2,4-dienal, 5-(4-dimethylamino-1-naphthyl)Penta-3,5-dienal, 9-methyl-3-carbase the aldehyde, 9-ethyl-3-carbazolyl, 3-acetylcarnosine, 3,6-diacetyl-9-ethylcarbazole, 3-acetyl-9-methylcarbazole, 1,4-dimethyl-3-carbazolyl, 1,4,9-trimethyl-3-carbazolyl, 6-nitropiperonyl, 2-nitropiperonyl, 5-nitrovanillin, 2,5-dinitrosalicylic aldehyde, 5-bromo-3-nitrosalicylic aldehyde, 3-nitro-4-formylbenzenesulfonic, bansilalpet, p-toluensulfonate, methanesulfonate, perchlorate, sulfate, chloride, bromide, iodide, tetrachlorozincate, methyl sulfate, triftorbyenzola or tetrafluoroborate 4-formyl-1-methylpyridine, 2-formyl-1-methylpyridine, 4-formulafeeding, 2-formyl-1-ethylpyridine, 4-formyl-1-benzylpyridine, 2-formyl-1-benzylpyridine, 4-formyl-1,2-dimethylpyridine, 4-formyl-1,3-dimethylpyridine, 4-formyl-1-methylinosine, 2-formyl-1-methylinosine, 5-formyl-1-methylinosine, 6-formyl-1-methylinosine, 7-formyl-1-methylinosine, 8-formyl-1-methylinosine, 5-formyl-1-ethylenamine, 6-formyl-1-ethylenamine, 7-formyl-1-ethylenamine, 8-formyl-1-ethylenamine, 5-formyl-1-benzylcyanide, 6-formyl-1-benzylcyanide, 7-formyl-1-benzylcyanide, 8-formyl-1-benzylcyanide, 5-formyl-1-allilkhinoliniem, 6-formyl-1-allilkhinoliniem, 7-formyl-1-and 8 allilkhinoliniem-formyl-1-allilkhinoliniem, isatin, 1-methylisatin, 1-ulilization, 1-hydroxymethylation, 5-chloroisatin, 5-methoxyisatin, 5-nitroisatin, 6-nitroisatin, 5-sulfonates, 5-carboxylicacid, genistin, 1-methyl-genistin, and that is any mixture of the above compounds.

Used as an additional component With reactive carbonyl compounds, which are derivatives of benzaldehyde, naphthaldehyde, respectively, cinnamic aldehyde, preferably chosen from the group comprising coniferious aldehyde, 2-methoxybenzaldehyde, 3-methoxybenzaldehyde, 4-methoxybenzaldehyde, 2-ethoxybenzaldehyde, 3-ethoxybenzaldehyde, 4-ethoxybenzaldehyde, 4-hydroxy-2,3-dimethoxybenzaldehyde, 4-hydroxy-2,5-dimethoxybenzaldehyde, 4-hydroxy-2,6-dimethoxybenzaldehyde, 4-hydroxy-2-methylbenzaldehyde, 4-hydroxy-2,3-dimethylbenzaldehyde, 4-hydroxy-2,5-dimethylbenzaldehyde, 4-hydroxy-2,6-dimethylbenzaldehyde, 3,5-diethoxy-4-hydroxybenzaldehyde, 2,6-diethoxy-4-hydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde, 2-ethoxy-4-hydroxybenzaldehyde, 3 ethoxy-4-hydroxybenzaldehyde, 4-ethoxy-2-hydroxybenzaldehyde, 4-ethoxy-3-hydroxybenzaldehyde, 2,3-dimethoxy-benzaldehyde, 2,4-dimethoxybenzaldehyde, 2,5-dimethoxybenzaldehyde, 2,6-dimethoxybenzaldehyde, 3,4-dimethoxybenzaldehyde, 3,5-dimethoxybenzaldehyde, 2,3,4-trimethoxybenzaldehyde, 2,3,5-trimethoxybenzaldehyde, 2,3,6-trimethoxybenzaldehyde, 2,4,6-trimethoxybenzaldehyde, 2,4,5-trimethoxybenzaldehyde, 2,5,6-trimethoxybenzaldehyde, 2-hydroxy-benzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxyben the aldehyde, 2,3-dihydroxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 2,4-dihydroxy-3-methylbenzaldehyde, 2,4-dihydroxy-5-methylbenzaldehyde, 2,4-dihydroxy-6-methylbenzaldehyde, 2,4-dihydroxy-3-methoxybenzaldehyde, 2,4-dihydroxy-5-methoxybenzaldehyde, 2,4-dihydroxy-6-methoxybenzaldehyde, 2.5-dihydroxybenzaldehyde, 2,6-dihydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, 3,4-dihydroxy-2-methylbenzaldehyde, 3,4-dihydroxy-5-methylbenzaldehyde, 3,4-dihydroxy-6-methylbenzaldehyde, 3,4-dihydroxy-2-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, 2,3,5-trihydroxybenzaldehyde, 2,3,6-trihydroxybenzaldehyde, 2,4,6-trihydroxybenzaldehyde, 2,4,5-trihydroxybenzaldehyde, 2,5,6-trihydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-diethylaminobenzaldehyde, 4-dimethylamino-2-hydroxybenzaldehyde, 4-pyrrolidineethanol, 4-morpholinomethyl, 2-morpholinomethyl, 4-piperidinemethanol, 3,5-dichloro-4-hydroxybenzaldehyde, 4-hydroxy-3,5-disadvantange, 3-chloro-4-hydroxybenzaldehyde, 5-chloro-3,4-dihydroxybenzaldehyde, 5-bromo-3,4-dihydroxybenzaldehyde, 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 4-hydroxy-3-iodine-5-methoxybenzaldehyde, 2-methoxy-1-naphthaldehyde, 4-methoxy-1-naphthaldehyde, 2-hydroxy-1-naphthaldehyde, 2,4-dihydroxy-1-naphthaldehyde, 4-hydroxy-3-methoxy-1-naphthaldehyde, 2-hydroxy-4-methoxy-1-naphthaldehyde, 3 guide is hydroxy-4-methoxy-1-naphthaldehyde, 2,4-dimethoxy-1-naphthaldehyde, 3,4-dimethoxy-1-naphthaldehyde, 4-dimethylamino-1-naphthaldehyde, 2-nitrobenzaldehyde, 3-nitrobenzaldehyde, 4-nitrobenzaldehyde, 4-methyl-3-nitrobenzaldehyde, 3-hydroxy-4-nitrobenzaldehyde, 5-hydroxy-2-nitrobenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde, 2-hydroxy-3-nitrobenzaldehyde, 2-fluoro-3-nitrobenzaldehyde, 3-methoxy-2-nitrobenzaldehyde, 4-chloro-3-nitrobenzaldehyde, 2-chloro-6-nitrobenzaldehyde, 5-chloro-2-nitrobenzaldehyde, 4-chloro-2-nitrobenzaldehyde, 2,4-dinitrobenzaldehyde, 2,6-dinitrobenzaldehyde, 2-hydroxy-3-methoxy-5-nitrobenzaldehyde, 4,5-dimethoxy-2-nitrobenzaldehyde, 6-nitropiperonyl, 2-nitropiperonyl, 5-nitrovanillin, 2,5-dinitrosalicylic aldehyde, 5-bromo-3-nitrosalicylic aldehyde, 4-nitro-1-naphthaldehyde, 2-nitromalonic aldehyde, 3-nitromalonic aldehyde, 4-aldehyde microcolony, 4-dimethylaminomethyl aldehyde, 2-dimethylaminobenzaldehyde, 2-chloro-4-dimethylaminobenzaldehyde, 4-dimethylamino-2-methylbenzaldehyde, 4-diethylaminomethyl aldehyde, 4-dibutylaminoethanol, 4-diphenylacetaldehyde, 4-(1-imidazolyl)benzaldehyde and piperonal. These substances are particularly preferred additional reactive carbonyl compounds used as component C.

From European patent application EP-A2-998 908, and Japanese application n the patent JP-A2-2002047153 specialists known products for hair coloring, which contain, in particular, as a direct dye, at least one connection to the rest of 1,2-dihydro-2-oxopyrimidine. Under the third option proposed in the invention coloring agent additionally contains as a direct dye, at least one product of the interaction derived 1,2-dihydro-2-oxopyrimidine formula (I) with component b (below called the reaction product RP). Such reaction products RP can be obtained, for example, by heating these reactants in the aqueous medium by reaction neutral to slightly alkaline, and the resulting reaction products RP fall out of solution as a precipitate solids or can be isolated by evaporation of the solution. In addition, similar to the RP can be obtained in accordance with the publication Nvamp and others in Liebigs Ann. Chem., 1968, 717, 124-136, or according to the German patent application DE-A1-2165913.

Appropriate variation of the molar ratio of the reagents (component and In the compounds of formula (I)used for the synthesis of the reaction product RP corresponds to the interval from 1:1 to about 2:1.

The content of the above compounds of formula (I), compounds used as component B, the compounds used as component C, and the reaction products RP, respectively, is from 0.03 to 65 mmol, primarily from 1 d is 40 mmol based on 100 g of the total coloring tools.

Proposed in the invention of painting means may additionally contain at least one component exhibiting and optionally at least one krasnobryzhyy component as initial products for the oxidation of the dye.

According to the invention as component exhibiting preferably possible to use a derivative of p-phenylenediamine or one of its physiologically compatible salts. Especially preferred are derivatives of p-phenylenediamine of the formula (E1):

in which

G1means a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, alkoxyalkyl residue with 1-4 carbon atoms, respectively, in the alkoxy and alkyl, 4'-AMINOPHENYL residue or an alkyl residue with 1 to 4 carbon atoms, substituted nitrogen-containing group or phenyl or 4'-aminoaniline balance,

G2means a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, alkoxyalkyl residue with 1-4 carbon atoms, respectively, in the alkoxy and alkyl, or substituted nitrogen-containing group, an alkyl residue with 1 to 4 atom is mi carbon

G3means a hydrogen atom, a halogen atom, such as chlorine, bromine, iodine or fluorine, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, hydroxyalkoxy residue with 1-4 carbon atoms, acetylaminofluorene residue with 1-4 carbon atoms, methylaminomethyl residue with 1-4 carbon atoms or carbamoylphenoxy residue with 1-4 carbon atoms,

G4means a hydrogen atom, halogen atom or alkyl residue with 1 to 4 carbon atoms,

or

G3and G4together may form a bridging α,ω-alkylenedioxy, such as Ethylenedioxy if they are in ortho-position relative to each other.

Examples of the above alkyl residues with 1 to 4 carbon atoms, is used as the substituents in the proposed invention the compounds of the formula (E1)are, for example, methyl, ethyl, propyl, isopropyl and butyl. Preferred alkyl residues are ethyl and methyl. According to the invention preferred closeline residues with 1-4 carbon atoms are, for example, methoxy or ethoxy. Examples of preferred hydroxyalkyl groups with 1-4 carbon atoms include hydroxymethyl, 2-hydroxyethyl, 3-hydroxypropyl or 4-hidroxi the Teal. Especially preferred is 2-hydroxyethyl. Especially preferred polyhydroxyalkane residue with 2 to 4 carbon atoms is 1,2-dihydroxyethylene group. According to the invention, examples of suitable halogen atoms are fluorine atoms, chlorine or bromine. Especially preferred are chlorine atoms. According to the invention other used in the description of the designations are derived from the above. Examples of nitrogen-containing groups in the formula (E1) are primarily amino group, monoalkylamines with 1-4 carbon atoms, dialkylamino with 1-4 carbon atoms in the alkyl, dialkylamino with 1-4 carbon atoms in the alkyl, monohydroxylation with 1-4 carbon atoms, imidazolin and ammonium.

Particularly preferred p-phenylenediamine formula (E1) is selected from the group comprising p-phenylenediamine, p-toluylenediamine, 2-chloro-p-phenylenediamine, 2,3-dimethyl-para-phenylenediamine, 2,6-dimethyl-p-phenylene-diamine, 2,6-diethyl-p-phenylenediamine, 2,5-dimethyl-p-phenylenediamine, N,N-dimethyl-p-phenylenediamine, N,N-diethyl-p-phenylenediamine, N,N-dipropyl-p-phenylenediamine, 4-amino-3-methyl-(N,N-diethyl)aniline, N,N-bis(β-hydroxyethyl)-p-phenylenediamine, 4-N,N-bis(β-hydroxyethyl)amino-2-methylaniline, 4-N,N-bis(β-hydroxyethyl)amino-2-Chloroaniline, 2-(β-hydroxyethyl)-p-phenylenediamine, 2-(α,β dihydroxyethyl)-p-phenylenediamine, 2-fluoro-p-FeNi is Indiamen, 2-isopropyl-p-phenylenediamine, N-(p-hydroxypropyl)-p-phenylenediamine, 2-hydroxymethyl-p-phenylenediamine, N,N-dimethyl-3-methyl-p-phenylenediamine, N,N-(ethyl,β-hydroxyethyl)-p-phenylenediamine, N-(β,γ-dihydroxypropyl)-p-phenylenediamine, N-(4'-AMINOPHENYL)-p-phenylenediamine, N-phenyl-p-phenylenediamine, 2-(β-hydroxyethyloxy)-p-phenylenediamine, 2-(β-acetamidoacrylate)-p-phenylenediamine, N-(β-methoxyethyl)-p-phenylenediamine, N-(4-amino-3-were)-N-[3-(1H-imidazol-1-yl)propyl]amine and 5.8-diaminobenzene-1,4-dioxane, and their physiologically acceptable salts.

According to the invention particularly preferred derivatives of p-phenylenediamine of the formula (E1) are p-phenylenediamine, p-toluylenediamine, 2-(β-hydroxyethyl)-p-phenylenediamine, 2-(α,β dihydroxyethyl)-p-phenylenediamine and N,N-bis-(β-hydroxyethyl)-p-phenylenediamine.

In addition, according to the invention as component exhibiting preferably possible to use compounds containing at least two aromatic nuclei substituted by amino and/or hydroxyl groups.

Dual manifesting components, which according to the invention can be used in coloring means, first and foremost are the compounds of formula (E2):

and their physiologically acceptable salt,

and

Z1and Z2independently from each other mean, hydroc the ilen or NH 2residue, which is optionally substituted alkyl residue with 1 to 4 carbon atoms, hydroxyalkyl residue with 1 to 4 carbon atoms and/or by a bridge Y, or, if necessary, is part forming a bridge ring system,

Y means the bridge formed alkalinous group with 1 to 14 carbon atoms, such as linear or branched Allenova chain or alkylene ring which may be interrupted or completed one or more nitrogenous groups and/or one or more heteroatoms such as oxygen atoms, sulfur or nitrogen, and in some cases substituted by one or more hydroxyl or CNS remains with 1-8 carbon atoms, or denotes a direct bond,

G5and G6independently from each other mean a hydrogen atom or a halogen, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, aminoalkyl residue with 1-4 carbon atoms or a direct bond to the bridge Y,

G7, G8, G9, G10G11and G12independently from each other mean a hydrogen atom, a direct bond to the bridge Y or alkyl residue with 1 to 4 carbon atoms,

provided that in the molecule of the compounds of formula (E2) contain only one bridge y

According to the invention contained in the compounds of formula (E2), the substituents similar to the substituents, above.

Preferred dual-core showing the components of the formula (E2) are primarily N,N'-bis-(β-hydroxyethyl)-N,N'-bis-(4'-AMINOPHENYL)-1,3-diaminopropan-2-ol, N,N'-bis(β-hydroxyethyl)-N,N'-bis-(4'-AMINOPHENYL)Ethylenediamine, N,N'-bis(4-AMINOPHENYL)tetramethylaniline, N,N'-bis(β-hydroxyethyl)-N,N'-bis(4'-AMINOPHENYL)tetramethylaniline, N,N'-bis(4-methylaminophenol)tetramethylaniline, N,N'-diethyl-N,N'-bis(4'-amino-3'-were)Ethylenediamine, bis(2-hydroxy-5-amino-phenyl)methane, N,N'-bis(4'-AMINOPHENYL)-1,4-disallowable, N,N'-bis(2-hydroxy-5-aminobenzyl)piperazine, N-(4'-AMINOPHENYL)-p-phenylenediamine, 1,10-bis-(2',5'-diaminophenyl)-1,4,7,10-tetraoxide and their physiologically acceptable salts.

Even more preferred dual-core showing the components of the formula (E2) are N,N'-bis(β-hydroxyethyl)-N,N'-bis(4'-AMINOPHENYL)-1,3-diaminopropan-2-ol, bis(2-hydroxy-5-AMINOPHENYL)methane, 1,3-bis(2,5-diaminophenoxy)propan-2-ol, N,N'-bis(4'-AMINOPHENYL)-1,4-disallowable and 1,10-bis-(2',5'-diaminophenyl)-1,4,7,10-tetraoxalate or one of the physiologically acceptable salts of these compounds.

In addition, according to the invention as component exhibiting preferably possible to use a derivative of p-aminophenol or one of its physiologically acceptable salts. Especially preferred are derivatives of p-aminophenol of the formula (E3):

in which

G13means a hydrogen atom, halogen, alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, alkoxyalkyl residue with 1-4 carbon atoms, respectively, in the alkoxy and alkyl, aminoalkyl residue with 1-4 carbon atoms in the alkyl, hydroxyethylamino residue with 1-4 carbon atoms in the alkyl, hydroxyalkoxy residue with 1-4 carbon atoms in the alkoxy, hydroxyethylaminomethyl residue with 1-4 carbon atoms in the alkyl or dialkylaminoalkyl residue with 1-4 carbon atoms in the alkyl and

G14means a hydrogen atom or a halogen, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, alkoxyalkyl residue with 1-4 carbon atoms, respectively, in the alkoxy and alkyl, aminoalkyl residue with 1-4 carbon atoms or cyanoaniline residue with 1-4 carbon atoms,

G15means hydrogen, an alkyl residue with 1 to 4 carbon atoms, monohydrocalcite residue with 1-4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, phenyl or benzyl residue, and

G16means a hydrogen atom or a halogen.

According to the invention contained in the compounds of formulas is (E3) the substituents similar to the substituents, above.

Preferred p-aminophenols of formula (E3) are primarily p-aminophenol, N-methyl-p-aminophenol, 4-amino-3-METHYLPHENOL, 4-amino-3-terfenol, 2-hydroxymethylamino-4-aminophenol, 4-amino-3-hydroxymethylene, 4-amino-2-(β-hydroxyethoxy)phenol, 4-amino-2-METHYLPHENOL, 4-amino-2-hydroxymethylene, 4-amino-2-hydroxymethylene, 4-amino-2-methoxypropanol, 4-amino-2-aminomethylphenol, 4-amino-2-(β-hydroxyethylaminomethyl)phenol, 4-amino-2-(α,β dihydroxyethyl)phenol, 4-amino-2-terfenol, 4-amino-2-chlorophenol, 4-amino-2,6-dichlorophenol, 4-amino-2-(diethylaminomethyl)phenol, and their physiologically acceptable salts.

Even more preferred compounds of the formula (E3) are p-aminophenol, 4-amino-3-METHYLPHENOL, 4-amino-2-aminomethylphenol, 4-amino-2-(α,β dihydroxyethyl)phenol and 4-amino-2-(diethylaminomethyl)-phenol.

Manifesting components can also be selected from the group comprising o-aminophenol and its derivatives, such as 2-amino-4-METHYLPHENOL, 2-amino-5-METHYLPHENOL or 2-amino-4-chlorophenol.

In addition, showing the components can be selected from heterocyclic showing components, such as derivatives of pyridine, pyrimidine, pyrazole, pyrazole-pyrimidine and their physiologically acceptable salts.

Preferred derivatives of pyridine are above all compounds described in atento UK GB 1026978 and GB 1153196, such as 2,5-diaminopyridine, 2-(4-methoxyphenyl)amino-3-aminopyridine, 2,3-diamino-6-methoxypyridine, 2-(β-methoxyethyl)amino-3-amino-6-methoxypyridine and 3,4-diaminopyridine.

Preferred pyrimidine derivatives are primarily compounds described in German patent DE 2359399, vykladem the description of the invention to Japanese application JP 02019576 A2 or international application WO 96/15765, such as 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2-dimethylamino-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopirimidina and 2,5,6-triaminopyrimidine.

Preferred derivatives of pyrazole are primarily compounds described in German patents DE 3 843 892 and DE 4 133 957, international applications WO 94/08969 and WO 94/08970, European patent EP-740931 and German patent DE 195 43 988, such as 4,5-diamino-1-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)pyrazole, 3,4-diaminophenol, 4,5-diamino-1-(4'-Chlorobenzyl)pyrazole, 4,5-diamino-1,3-dimethylpyrazole, 4,5-dimethyl-3-methyl-1-phenylpyrazole, 4,5-dimethyl-1-methyl-3-phenylpyrazole, 4-amino-1,3-dimethyl-5-hydrazinophenyl, 1-benzyl-4,5-diamino-3-methylpyrazole, 4,5-diamino-3-tert-butyl-1-methylpyrazole, 4,5-diamino-1-tert-butyl-3-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole, 4,5-diamino-1-ethyl-3-methylpyrazole, 4,5-diamino-1-ethyl-3-(4'-methoxyphenyl)pyrazole, 4,5-diamino-1-ethyl-3-hydroxymethylbilane is, 4,5-diamino-3-hydroxymethyl-1-methylpyrazole, 4,5-diamino-3-hydroxymethyl-1-isopropylpyrazole, 4,5-diamino-3-methyl-1-isopropylpyrazole, 4-amino-5-(β-amino-ethyl)amino-1,3-dimethylpyrazole, 3,4,5-diaminophenol, 1-methyl-3,4,5-diaminophenol, 3,5-diamino-1-methyl-4-methylaminophenol and 3,5-diamino-4-(β-hydroxyethyl)amino-1-methylpyrazole.

Preferred derivatives of pyrazole-pyrimidine are primarily derivatives of pyrazole[1,5-a]pyrimidine of the formula (E4):

and in the presence of tautomeric equilibrium corresponding tautomeric forms,

and

G17, G18, G19and G20independently from each other mean a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms, an aryl residue, a hydroxyalkyl residue with 1 to 4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, alkoxyalkyl residue with 1-4 carbon atoms, respectively, in the alkoxy and alkyl, aminoalkyl residue with 1-4 carbon atoms, which may optionally be protected acetylurea or sulfanilyl balance, acylaminoalkyl residue with 1-4 carbon atoms in the alkyl, dialkylaminoalkyl residue with 1-4 carbon atoms in the alkyl, and disciline residues optionally form a carbon cycle or a heterocycle with five or six members, hydroxyethylaminomethyl residue with 1-4 and what Ohm carbon in the alkyl or dihydroxyquinoline residue with 1-4 carbon atoms in the alkyl,

X independently of one another mean a hydrogen atom, an alkyl residue with 1 to 4 carbon atoms, an aryl residue, a hydroxyalkyl residue with 1 to 4 carbon atoms, polyhydroxyalkane residue with 2 to 4 carbon atoms, aminoalkyl residue with 1-4 carbon atoms, acylaminoalkyl residue with 1-4 carbon atoms in the alkyl, dialkylaminoalkyl residue with 1-4 carbon atoms in the alkyl, and disciline residues optionally form a carbon cycle or a heterocycle with five or six members, hydroxyethylaminomethyl residue with 1-4 carbon atoms in the alkyl or dihydroxyquinoline residue with 1-4 carbon atoms in the alkyl, amine residue, alkylamine residue with 1 to 4 atoms carbon or dihydroxyethylene residue with 1-4 carbon atoms in the alkyl, halogen atom, carboxyl group or sulfonylurea group,

i is 0, 1, 2 or 3,

p denotes 0 or 1,

q is 0 or 1, and

n means 0 or 1,

provided that

the sum p+q is not 0,

- if the sum of p+q is 2, n is 0, and the groups NG17G18and NG19G20are in position(2, 3), (5, 6), (6, 7), (3, 5) or (3,7),

- if the sum of p+q is equal to 1, n is 1, and the group NG17G18(or NG19G20and HE -- group are in the position(2, 3), (5, 6), (6, 7), (3, 5) or (3, 7).

According to the invention contained in the compounds f is rmula (E4) the substituents similar to the substituents, above.

If pyrazole[1,5-α]pyrimidine of the above formula (E4) contains a hydroxyl group in position 2, 5 or 7 of the ring system, there is a tautomeric equilibrium, which can be represented, for example, by the equation:

To the pyrazole[1,5-a]pyrimidines of the above formula (E4) primarily include the following compounds:

- pyrazole[1,5-a]pyrimidine-3,7-diamine,

- 2.5-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,

- pyrazole[1,5-a]pyrimidine-3,5-diamine,

- 2,7-dimethylpyrazolo[1,5-a]pyrimidine-3,5-diamine,

- 3-aminopyrazole[1,5-a]pyrimidine-7-ol,

- 3-aminopyrazole[1,5-a]pyrimidine-5-ol,

- 2-(3-aminopyrazole[1,5-a]pyrimidine-7-ylamino)ethanol

- 2-(7-aminopyrazole[1,5-a]pyrimidine-3-ylamino)ethanol

- 2-[(3-aminopyrazole[1,5-a]pyrimidine-7-yl)(2-hydroxyethyl)amino]ethanol,

- 2-[(7-aminopyrazole[1,5-a]pyrimidine-3-yl)(2-hydroxyethyl)amino]ethanol,

- 5,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,

- 2,6-dimethylpyrazolo[1,5-a]pyrimidine-3,7-diamine,

- 3-amino-7-dimethylamino-2,5-dimethylpyrazolo[1,5-a]pyrimidine,

and their physiologically acceptable salts and tautomeric forms (with the existence of tautomeric equilibrium).

Pyrazole[1,5-a]pyrimidines of the above formula (E4) can be obtained by known literature methods cyclization based on aminopyrazole or hydrazine.

In another paragraph edocfile variant proposed in the invention coloring products contain at least one krasnobryzhyy component.

As ceskobratrska component, typically use derivatives of m-phenylenediamine, naftaly, resorcinol and derivatives of resorcinol, pyrazolones and derivatives of m-aminophenol. Fit the actual pigment components are primarily 1-naphthol, 1,5-dihydroxynaphthalene, 2,7-dihydroxynaphthalene and 1.7-dihydroxynaphthalene, 5-amino-2-METHYLPHENOL, m-aminophenol, resorcinol, simple onomatology ether of resorcinol, m-phenylenediamine, 1-phenyl-3-methylpyrazole-5,2,4-dichloro-3-aminophenol, 1,3-bis(2',4'-diaminophenoxy)propane, 2-chlororesorcinol, 4-chlororesorcinol, 2-chloro-6-methyl-3-aminophenol, 2-amino-3-hydroxypyridine, 2-methylresorcinol, 5-methylresorcinol and 2-methyl-4-chloro-5-aminophenol.

According to the invention the preferred actual pigment components are the following connections:

m-aminophenol and its derivatives, such as 6-amino-2-METHYLPHENOL, N-cyclopentyl-3-aminophenol, 3-amino-2-chloro-6-methyl-phenol, 2-hydroxy-4-aminophenoxyethanol, 2,6-dimethyl-3-aminophenol, 3-triptorelin-2-chloro-6-METHYLPHENOL, 5-amino-4-chloro-2-methyl-phenol, 5-amino-4-methoxy-2-METHYLPHENOL, 5-(2'-hydroxyethyl)amino-2-METHYLPHENOL, 3-(diethylamino)phenol, N-cyclopentyl-3-aminophenol, 1,3-dihydroxy-5-(methylamino)benzene, 3-ethylamino-4-METHYLPHENOL and 2,4-dichloro-3-aminophenol;

o-aminophenol and its derivatives,

m-diaminobenzene and its derivatives, such as 2,4-diami ofanxiety, 1,3-bis-(2',4'-diaminophenoxy)propane, 1-methoxy-2-amino-4-(2'-hydroxyethylamino)benzene, 1,3-bis(2',4'-diaminophenyl)-propane, 2,6-bis(2'-hydroxyethylamino)-1-methylbenzol, 2-({3-[(2-hydroxy-ethyl)amino]-4-methoxy-5-were}amino)ethanol, 2-({3-[(2-hydroxy-ethyl)amino]-2-methoxy-5-were}amino)ethanol, 2-[3-morpholine-4-yl-phenyl)amino]ethanol, 3-amino-4-(2-methoxyethoxy)-5-methylphenylamine and 1-amino-3-bis(2'-hydroxyethyl)aminobenzene;

o-diaminobenzene and its derivatives such as 3,4-diaminobenzoic acid and 2,3-diamino-1-methylbenzol;

derivatives dihydroxybenzene and trihydroxybenzene, such as resorcinol, simple onomatology ether of resorcinol, 2-methylresorcinol, 5-methylresorcinol, 2.5-demetallization, 2-chlororesorcinol, 4-chlororesorcinol, pyragollole and 1,2,4-trihydroxybenzene;

derivatives of pyridine, for example, such as 2,6-dihydroxypyridine, 2-amino-3-hydroxypyridine, 2-amino-5-chloro-3-hydroxypyridine, 3-amino-2-methylamino-6-methoxypyridine, 2,6-dihydroxy-3,4-dimethylpyridine, 2,6-dihydroxy-4-methylpyridine, 2,6-diaminopyridine, 2,3-diamino-6-methoxypyridine and 3,5-diamino-2,6-dimethoxypyridine;

derivatives of naphthalene, such as 1-naphthol, 2-methyl-1-naphthol, 2-hydroxymethyl-1-naphthol, 2-hydroxyethyl-1-naphthol, 1,5-dihydroxynaphthalene, 1,6-dihydroxynaphthalene, 1,7-dihydroxynaphthalene, 1,8-dihydroxynaphthalene, 2,7-dihydroxynaphthalene and 2,3-digitoxin is lean;

derivatives of the research, such as 6-hydroxybenzomorpholine and 6-aminobenzonitrile;

derivatives finokalia, such as 6-methyl-1,2,3,4-Tetra-hydrogenation;

derivatives of pyrazole, such as 1-phenyl-3-methylpyrazole-5-he;

derivatives of indole, such as 4-hydroxyindole, 6-hydroxyindole and 7-hydroxyindole;

derivatives of pyrimidine, such as 4,6-diaminopirimidina, 4-amino-2,6-dihydroxypyrimidine, 2,4-diamino-6-hydroxypyrimidine, 2,4,6-trihydroxypyrimidine, 2-amino-4-methylpyrimidine, 2-amino-4-hydroxy-6-methylpyrimidine and 4,6-dihydroxy-2-methylpyrimidine, or

derivatives methylenedioxybenzene, such as 1-hydroxy-3,4-methylenedioxybenzene, 1-amino-3,4-methylenedioxybenzene and 1-(2'-hydroxy-ethyl)amino-3,4-methylenedioxybenzene,

as well as their physiologically compatible salts.

According to the invention particularly preferred actual pigment components are 1-naphthol, 1,5-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, 1,7-dihydroxynaphthalene, 3-aminophenol, 5-amino-2-METHYLPHENOL, 2-amino-3-hydroxypyridine, resorcinol, 4-chlororesorcinol, 2-chloro-6-methyl-3-aminophenol, 2-methylresorcinol, 5-methylresorcinol, 2.5-demetallization and 2,6-dihydroxy-3,4-dimethylpyridine.

In addition, in accordance with the fifth option in the proposed in the invention of painting media as a source the products for dyes, similar natural dyes, can be used preferably such indoles and indoline that contain at least one hydroxyl or amino group, preferably as a substituent six-membered rings. Such groups can be converted to other substituents, such as hydroxyl groups can be converted to ester groups or the group of ester or amino groups can be subjected to alkylation. According to the second preferred variant of the painting means contain at least one derivative of indole and/or indoline.

Especially suitable source products dyes for hair, similar to the natural dyes are derivatives of 5,6-dihydroxyindoline formula (IIIa):

in which, independently of each other

G21means hydrogen, alkyl group with 1-4 carbon atoms or hydroxyalkyl group with 1-4 carbon atoms,

G22means hydrogen or carboxyl group, which may be in salt form, containing a physiologically acceptable cation,

G23means hydrogen or alkyl group with 1-4 carbon atoms,

G24means hydrogen, alkyl group with 1-4 carbon atoms or a group-CO-G26in which

G26means an alkyl group with 1-4 atom is mi carbon and

G25similar G24,

as well as physiologically acceptable salts of the compounds of the formula (IIIa) with organic or inorganic acids.

Especially preferred derivatives indoline are 5,6-dihydroxyindoline, N-methyl-5,6-dihydroxyindoline, N-ethyl-5,6-dihydroxyindoline, N-propyl-5,6-dihydroxyindoline, N-butyl-5,6-dihydroxyindoline, 5,6-dihydroxyindoline-2-carboxylic acid and 6-hydroxyindole, 6-aminoindole and 4-aminoindole.

Even more preferred derivatives indoline are N-methyl-5,6-dihydroxyindoline, N-ethyl-5,6-dihydroxyindoline, N-propyl-5,6-dihydroxyindoline, N-butyl-5,6-dihydroxyindoline and primarily 5,6-dihydroxyindoline.

In addition, for use as primary products colouring agents for hair similar to natural dyes, perfectly suitable derivatives of 5,6-dihydroxyindoline formula (IIIb):

in which, independently of each other

G27means hydrogen, alkyl group with 1-4 carbon atoms or hydroxyalkyl group with 1-4 carbon atoms,

G28means hydrogen or carboxyl group, which may be in salt form, containing a physiologically acceptable cation,

G29means hydrogen or alkyl group with 1-4 carbon atoms,

G30means hydrogen,alkyl group with 1-4 carbon atoms or a group-CO-G 32in which

G32means an alkyl group with 1-4 carbon atoms, and

G31similar G30,

as well as physiologically acceptable salts of the compounds of formula (IIIb) with organic or inorganic acids.

Especially preferred derivatives of indole are 5,6-dihydroxyindole, N-methyl-5,6-dihydroxyindole, N-ethyl-5,6-dihydroxyindole, N-propyl-5,6-dihydroxyindole, N-butyl-5,6-dihydroxyindole, 5,6-dihydroxyindole-2-carboxylic acid, 6-hydroxyindole, 6-aminoindole and 4-aminoindole.

Even more preferred indole derivatives are N-methyl-5,6-dihydroxyindole, N-ethyl-5,6-dihydroxyindole, N-propyl-5,6-dihydroxyindole, N-butyl-5,6-dihydroxyindole and foremost 5,6-dihydroxyindole.

Derivatives indoline and indole can be used in the proposed invention coloring means in the form of free bases and in the form of corresponding physiologically acceptable salts with inorganic or organic acids, for example, hydrochloride, sulfates and hydrobromides. The contents of the derivatives indoline or indole in the coloring means is usually from 0.05 to 10 wt.%, preferably from 0.2 to 5 wt.%.

From the presence of oxidizing agents in the proposed in the invention of painting tools, such as the presence of hydrogen peroxide, can be waived, first of all, what if the painting means not contain the original products of oxidative dyes. If the proposed invention coloring products contain oxidizable air source products for oxidative dyes or derivatives of indole, respectively indoline, the rejection of the use of oxidizing agents is not accompanied by the appearance of any problems. However, in certain situations to obtain lighter shades in comparison with the color of the subject to paint containing keratin fibers may be necessary to add hydrogen peroxide or other oxidizing agents. The content of the oxidizing agent generally ranges from 0.01 to 6 wt.% in the terms used for the dyeing solution. The preferred oxidizing agent used for the dyeing of human hair, is hydrogen peroxide. You can also use a mixture of several oxidizing agents, such as combining hydrogen peroxide with peroxodisulfate metals or alkaline-earth metal or combination of sources of iodine ions, such as iodides of alkali metals, hydrogen peroxide or specified peroxodisulfate. According to the invention the oxidizing agent, respectively, a combination of oxidizing agents can be used in Crusades tool for hair in combination with oxidation catalysts. The oxidation catalysts of mo is ut to be for example, metal salts, chelate complexes of metals or metal oxides with the ability to easily transition from one oxidation state of the metal ion to another. Examples of such catalysts are salts, chelate complexes or oxides of iron, ruthenium, manganese and copper. Other possible oxidation catalysts are enzymes. Suitable enzymes include, for example, peroxidase, can significantly enhance the action of small quantities of hydrogen peroxide. In addition, according to the invention are suitable enzymes, which in the presence of oxygen directly oxidize the initial products of oxidation dyes, such as laccase, or form small amounts of hydrogen peroxide in situ and, therefore, biocatalytic activate the oxidation of the starting products for dyes. Particularly suitable catalysts for the oxidation of primary products for dyes are the so-called two-electron oxidoreductase in conjunction with the relevant specific substrates, for example

- pianosounds and, for example, D-glucose or galactose,

- glucose oxidase and D-glucose,

- glycerol oxidase and glycerol

- piruwatkinaza and benvinguda acid or its salt,

- alcoholecstasy and alcohol (methanol, ethanol),

- lactators data and lactic acid and its salt,

- tyrosinekinase and tyrosine,

- uricase and uric acid or its salt,

- cholinesterase and choline,

- amino acid oxidase and amino acids.

In accordance with the sixth option with the aim of modifying the color of the shades offered in the invention coloring tools along with contained therein according to the invention compounds additionally contain common direct dyes, such as nitrofurantoin, nitrolingual, azo dyes, anthraquinones or iodophenol. Preferred direct dyes are known compounds with the following international symbols, respectively trade names: NA Yellow 2, HC Yellow 4, HC Yellow 5, HC Yellow 6, HC Yellow 12, Acid Yellow 1, Acid Yellow 10, Acid Yellow 23, Acid Yellow 36, HC Orange 1, Disperse Orange 3, Acid Orange 7, HC Red 1, HC Red 3, HC Red 10, HC Red 11, HC Red 13, Acid Red 33, Acid Red 52, HC Red BN, Pigment Red 57:1, HC Blue 2, HC Blue 12, Disperse Blue 3, Acid Blue 7, Acid Green 50, HC Violet 1, Disperse Violet 1, Disperse Violet 4, Acid Violet 43, Disperse Black 9, Acid Black 1, and Acid Black 52, as well as 1,4-diamino-2-nitrobenzene, 2-amino-4-NITROPHENOL, 1,4-bis(β-hydroxyethyl)amino-2-nitrobenzene, 3-nitro-4-(β-hydroxyethyl)aminophenol, 2-(2'-hydroxyethyl)-amino-4,6-dinitrophenol, 1-(2'-hydroxyethyl)amino-4-methyl-2-nitrobenzene, 1-amino-4-(2'-hydroxyethyl)amino-5-chloro-2-nitrobenzene, 4-amino-3-NITROPHENOL, 1-(2'-areideal)amino-4-nitrobenzene, 4-amino-2-nitrodiphenylamine-2'-carboxylic acid, 6-nitro-1,2,3,4-tetr hydrogenation, 2-hydroxy-1,4-naphthoquinone, picramic acid and its salts, 2-amino-6-chloro-4-NITROPHENOL, 4-ethylamino-3-nitrobenzoic acid and 2-chloro-6-ethylamino-1-hydroxy-4-nitrobenzene.

In addition, the proposed invention in painting means preferably may contain cationic direct dyes. Such dyes preferably include the following:

(a) cationic triphenylmethane dyes such as Basic Blue 7, Basic Blue 26, Basic Violet 2 and Basic Violet 14,

(b) aromatic systems substituted by the group of Quaternary nitrogen, such as Basic Yellow 57, Basic Red 76, Basic Blue 99, Basic Brown 16 and Basic Brown 17, as well as

(C) direct dyes containing heterocycle with at least one Quaternary nitrogen atom, for example the dyes presented in paragraphs 6-11 of the claims of the European patent application EP-A2-998 908, which in this case should be considered an explicit reference.

Preferred cationic direct dyes of group (C) are especially the following connections:

Compounds of formula (DZ1), (DZ3) and (DZ5) are the camping even more preferred cationic direct dyes of group (C). Cationic direct dyes sold under the trade name Arianor®according to the invention are particularly preferred direct dyes.

Proposed in the invention of painting means according to the above variant preferably contain from 0.01 to 20 wt.% direct dyes in terms of the total coloring agent.

In addition, in the structure proposed in the invention of painting tools may also include natural colorants, such as dyes contained in the henna reddish-brown, henna neutral, henna black, chamomile flowers, sandal wood, black tea, buckthorn bark, sage, sandal wood tree (blue sandale), madder root, betel, sedre and root alkanna.

Not necessarily, if necessary, contained direct dyes were an appropriate uniform connection. On the contrary, in connection with the peculiarities of the technology of the individual dyes in the proposed in the invention of painting tools can be present minor amounts of other components, provided that they do not have a negative effect on the coloring, or from their use should be avoided because of other reasons, for example due to their inherent toxicity.

For more and more intense colors offer is the invention of painting means may additionally contain color enhancers. They are preferably chosen from the group comprising piperidine, piperidine-2-carboxylic acid, piperidine-3-carboxylic acid, piperidine-4-carboxylic acid, pyridine, 2-hydroxypyridine, 3 hydroxypyridine, 4-hydroxypyridine, imidazole, 1-Mei, arginine, histidine, pyrrolidine, Proline, pyrrolidone, pyrrolidone-2-carboxylic acid, pyrazole, 1,2,4-triazole, piperidine, corresponding derivatives and physiologically acceptable salts.

The contents of the specified color enhancers may be from 0.03 to 65 mmol, primarily from 1 to 40 mmol, respectively, based on 100 g of the total coloring tools.

Proposed in the invention coloring tools provide intense colors already at physiologically acceptable temperatures, which corresponds to the region below 45°C. In this regard, they are particularly suitable for dyeing human hair. For the purpose of dyeing human hair coloring tools are typically injected into the water-containing cosmetic bases. Suitable water-containing cosmetic bases are, for example, creams, emulsions, gels or containing surfactant solutions, such as shampoos, or other composition suitable for use in containing keratin fibers. Painting means if necessary, you can enter and bezvodninskii.

In addition, the proposed invention in painting means can include any commonly used in such compositions the active substances, additives and auxiliary funds. Painting means in many cases contain at least one surface-active substance (surfactant), and are suitable in principle are both anionic and zwitter-ionic, amphoteric, nonionic and cationic surfactants. However, in many cases, the preferred is the use of anionic, zwitter-ionic or nonionic surfactants.

Anionic surfactants suitable for use in the proposed in the invention compositions is any anionic surfactant that can be applied in the means of body care. Such surfactants are characterized by the presence ensures the solubility of the anionic group such as carboxylate, sulphate, sulphonate or phosphate group and a lipophilic alkyl group from about 10 to 22 carbon atoms. In addition, in the molecule such surfactants may be present in the group of glycol or polyglycol, ester groups, simple ester and amide groups, and hydroxyl groups. Examples of suitable anionic surfactants are the following compounds used in the form of corresponding salts of sodium, potassium and ammonium, and mono-, di - and trialkanolamines the two or three carbon atoms in alkanones group:

linear fatty acids with 10 to 22 carbon atoms (Soaps),

- alkoxycarbonyl acid of the formula R-O-(CH2-CH2O)x-CH2-COOH, in which R denotes a linear alkyl group with 10 to 22 carbon atoms, x is 0 or a number from 1 to 16,

- acylcarnitine with 10-18 carbon atoms in the acyl group,

- acylurea with 10-18 carbon atoms in the acyl group,

- utilizationin with 10-18 carbon atoms in the acyl group,

- complex monoalkyl and dialkyl ethers sulfonterol acid of 8-18 carbon atoms in the alkyl group and complex monoacylglycerol esters sulfonterol acid of 8-18 carbon atoms in the alkyl group containing from 1 to 6 oxyethyl groups,

- linear alkanesulfonyl with 12-18 carbon atoms,

linear α-reincorporate with 12-18 carbon atoms,

- methyl ester of α-sulfazine acid with 12-18 carbon atoms in sulfoxylate the rest,

the alkyl sulphates and alkylpolyglycoside formula R-O(CH2-CH2O)x-SO3H, in which R is preferably a linear alkyl group with 10 to 18 carbon atoms, x is 0 or a number from 1 to 12,

- mixtures of surface-active hydroxysulphate according to the German patent application DE-A-3725030,

- sulfated hydroxyacylglutathione and/or hydroxyethylaminophenol is according to the German patent application DE-A-3723354,

- sulfonates of unsaturated fatty acids with 12 to 24 carbon atoms and 1 to 6 double bonds according to the German patent application DE-A-3926344,

- esters of tartaric acid and citric acid with alcohols which are addition products of from 12 to 15 molecules of ethylene oxide and/or propylene oxide to aliphatic alcohols with 8-22 carbon atoms.

Preferred anionic surfactants are the alkyl sulphates, alkylpolyglycoside and alkoxycarbonyl acid having 10-18 carbon atoms in the alkyl group, containing up to 12 glycol groups in the molecule, and primarily salts of saturated and especially unsaturated carboxylic acids with 8-22 carbon atoms, such as oleic acid, stearic acid, ezoterikova acid and palmitic acid.

Under zwitter-ionic surfactants mean surface-active compounds, the molecule of which contains at least one Quaternary ammonium group and at least one group-soo(-)or-SO3(-). Especially suitable zwitter-ionic surfactants are the so-called betaines, such as glycine chelates of N-alkyl-N,N-dimethylammonio, such as glycinin of cocoalkylamine, glycine chelates of N-acylaminoacyl-N,N-dimethylammonio, such as glycinin of kokosalkilammonia, and 2-alkyl-3-carboxymethyl-3-hydroxymethylimidazole with 8-18 carbon atoms the alkyl or acyl group, and chocolatechipcookierecipe. Preferred zwitter-ionic surfactant is derived amide of fatty acid, known under the name "cocoamidopropyl betaine" (according to the nomenclature of the Association for perfume and cosmetic products and fragrances - CTFA).

Under amphoteric surfactants imply such surface-active compounds in the molecule which, along with the alkyl or acyl group with 8-18 carbon atoms contains at least one free amino group and at least one group-COOH or-SO3N and which are capable of forming internal salts. Examples of suitable amphoteric surfactants are N-allylglycine, N-alkylphosphonate acid, N-acylaminoalkyl acid, N-alkylaminocarbonyl acid, N-hydroxyethyl-N-alkylamidoamines, N-alkyltin, N-acylcarnitine, 2-alkylenediamine and alkylaminocarbonyl acid, respectively, with 8-18 carbon atoms in the alkyl group. Particularly preferred amphoteric surfactants are N-cocoalkylamine-propionate, N-chocolateeeeeeeeeeeeeee and azilsartan with 12-18 carbon atoms.

Non-ionic surfactants as the hydrophilic group include, for example, polyol as one group, group polyalkyleneglycol or a combination of polyol as one group with a group of polyalkyleneglycol. Such compounds and are, for example,

- addition products of 2 to 30 moles of ethylene oxide and/or 0 to 5 moles of propylene oxide to aliphatic alcohols with 8-22 carbon atoms, fatty acids with 12-22 carbon atoms and to alkyl phenols with 8 to 15 carbon atoms in the alkyl group,

- complex monetary and diesters of fatty acids with 12-22 carbon atoms and products joining from 1 to 30 moles of ethylene oxide to glycerin,

- alkylhalogenide and alkylpolyglycoside with 8-22 carbon atoms in the alkyl and their ethoxylated analogs,

- addition products of 5 to 60 moles of ethylene oxide to castor oil and otverzhdennom castor oil,

- addition products of ethylene oxide to esters of sorbitol and fatty acids,

- addition products of ethylene oxide to alkanolamide fatty acids.

Examples of cationic surfactants that can be used in the proposed in the invention of painting tools that are primarily of Quaternary ammonium compounds. Preferred surfactants are ammonium halides, such as chlorides of alkyltrimethylammonium, chlorides of dialkyldimethylammonium and chlorides of trialkylamine, for example chloride, cetyltrimethylammonium, chloride of stearylamine, chloride of distearyldimethylammonium, chloride of lauryldimethylamine, chloride of lauryldimethylamine or chloride of triethylmethylammonium. Other cation is AB, which can be used according to the invention are quaternion products of hydrolysis of proteins.

In addition, according to the invention is suitable cationic silicone oils such as commercially available products Q2-7224 (stable trimethylsilylamodimethicone, the company Dow Corning), emulsion Dow Corning 929 (contains modified with hydroxylamine silicone, also known as amodimethicone), SM-2059 (General Electric), SLM-55067 (Wacker), and Abil®-Quat 3270 and 3272 (dicerorhinus polydimethylsiloxane, Quaternium-80, firm Th. Goldschmidt).

Alkylamidoamines primarily amidoamine fatty acids, such commercially available stearamidopropyl with the trade name Tego Amid®S 18, along with the optimal conditioning effect are particularly high capacity for biological destruction.

Extremely high capacity for biological degradation have also Quaternary esters, so-called exterkate, such as sold under the trade name Stepantex®methosulfate of methylhydroxyethylcellulose.

An example of a Quaternary derivative of sugar, suitable for use as the cationic surfactant is the commercial product Glucquat®100, according to CTFA nomenclature called "lauryl mate the Gluceth-10 hydroxypropyl dimonium chloride".

Used as surfactant compounds with alkyl groups may be appropriate uniform surface-active substances. However, synthesis of these surfactants usually preferable to use natural raw materials of vegetable or animal origin, and therefore are formed of a mixture of substances with different length of alkyl residues, depending on the source of raw materials.

As the surfactant, which represent addition products of ethylene oxide and/or propylene oxide to aliphatic alcohols or derivatives of these products, you can use the products as "normal", and with a narrow distribution of homologues. Under products with a "normal" distribution of homologues mean mixtures of homologs which are obtained by interaction of aliphatic alcohol with alkalization carried out using alkali metals, hydroxides of alkali metals or alkali metal alcoholate as a catalyst. Unlike products with a "normal" distribution of homologues products with their narrow distribution of gain, using as catalysts, for example, hydrotalcite, salts of alkaline-earth metals with alkoxycarbonyl acids, oxides, hydroxide or alcoholate of alkaline-earth metals. It is preferable to use about what aktov with narrow distribution of homologues.

Examples of optionally used active substances, additives and supplements are

- non-ionic polymers, such as copolymers of vinylpyrrolidone with vinylacetate, polyvinylpyrrolidone, copolymers of vinylpyrrolidone with vinyl acetate and polysiloxane,

cationic polymers, such as quaternion ethers of cellulose, polysiloxanes with Quaternary groups, polymers chloride of dimethyldiallylammonium, copolymers of acrylamide with chloride of dimethyldiallylammonium, quaternion diethylsulfate copolymers dimethylaminoethylmethacrylate with vinyl pyrrolidone, copolymers of vinylpyrrolidone with methochloride imidazoline and Quaternary polyvinyl alcohol,

- zwitter-ionic and amphoteric polymers, such as copolymers of chloride of acrylonitrilebutadiene with acrylate and copolymers of octylacrylamide with methyl methacrylate, tert-butyl-aminoethylethanolamine and 2-hydroxypropylmethacrylate,

- anionic polymers such as polyacrylic acid, crosslinked polyacrylic acid, copolymers of vinyl acetate with crotonic acid, copolymers of vinylpyrrolidone with vinylacetate, copolymers of vinyl acetate with butylmalonate and isobutylacetate, copolymers metilfenidato ether with maleic anhydride and ternary copolymers of acrylic acid, e is elecrolyte and N-tert-butylacrylamide,

- thickeners, such as agar-agar, guar gum, alginates, xanthan gum, gum Arabic, gum of sterculia burning, carob flour-krupchatka, gum, flax meal, dextrans, cellulose derivatives such as methylcellulose, hydroxyethylcellulose and carboxymethylcellulose, fractions of starch and its derivatives, such as amylose, amylopectin and dextrins, clays such as bentonite or fully synthetic hydrocolloids such as polyvinyl alcohol,

- structuring agents, such as cellulose and maleic acid,

- a means of conditioning the hair, such as phospholipids, for example soya lecithin, egg lecithin and cephalin, and silicone oil,

the hydrolysates of proteins, primarily products of the hydrolysis of elastin, collagen, keratin, milk protein, soya protein and wheat protein products of condensation of fatty acids and quaternion hydrolysates of proteins,

aromatic oils, dimetridazole and cyclodextrins,

- substances that contribute to the dissolution, such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and diethylene glycol,

- active agents dandruff, such as pyrogenalum and lincomycin,

- additional substances for regulation of pH,

- active substances, such as panthenol, Pantothenic acid, allantoin, pyrrolidonecarboxylic acids and their salts, plant extracts and vitamins,

- cholesterol,

- light stabilizers,

- consistency regulators, such as esters of sugars, esters of polyhydric alcohols or simple alkalemia esters of polyhydric alcohols,

fats and waxes, such as spermaceti, beeswax, lignite wax, paraffins, aliphatic alcohols and esters of fatty acids,

- alkanolamide fatty acids,

- complexing agents such as ethylenediaminetetraacetic acid, nitrilotriacetic and phosphonic acid,

- substances that contribute to the swelling and penetration, such as glycerin, monotropy ether of propylene glycol, carbonates, bicarbonates, guanidine and urea, as well as primary, secondary and tertiary phosphates, imidazoles, tannins and pyrrole,

means to impart opacity, such as latex,

substances to impart a pearlescent luster, such as glycol monostearate and distearate ethylene glycol

- foaming agents, such as propanebutane mixture, nitrous oxide, dimethyl ether, carbon dioxide and air,

- antioxidants.

When preparing proposed in the invention means for coloring aqueous components of the framework used in common for this when edst concentrations; for example, the content of the emulsifier is from 0.5 to 30 wt.%, thickener from 0.1 to 25 wt.% in terms of the total tool for painting.

Favorable impact on the results of staining may have added to the means for coloring the ammonium salts or metal salts. Suitable metal salts are, for example, formate, carbonates, halides, sulfates, butyrate, valerate, caproate, acetates, lactates, glycolate, tartratami, citrate, gluconate, propionate, phosphates and phosphonates of alkali metals such as potassium, sodium or lithium, alkaline earth metals such as magnesium, calcium, strontium or barium, or aluminum, manganese, iron, cobalt, copper or zinc, and preferred are sodium acetate, lithium bromide, calcium bromide, calcium gluconate, zinc chloride, zinc sulfate, magnesium chloride, magnesium sulfate, ammonium carbonate, ammonium chloride and ammonium acetate. The preferred content of these salts is from 0.03 to 65 mmol, primarily from 1 to 40 mmol per 100 g of the total funds for painting.

PH ready-to-use tools for painting typically ranges from 2 to 11, preferably from 5 to 10.

The second object of the present invention is the use of at least one of the compounds of formula (I)

and/or its enaminones form, and

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,

X-means physiologically acceptable anion,

together with used as a component in at least one aldehyde selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy 1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxy-benzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde,

as the coloring component in the means for hair coloring.

In the preferred embodiment, as the coloring component in the means for coloring hair using those related to the first object of the present invention compounds of formula (I)indicated above as preferred and particularly preferred.

In addition, tools for hair coloring as the dye component can preferably be used at least one implement is operating the product RP of the compounds of formula (I) and the representative of the Century

The third object of the present invention is a method of containing coloring keratin fibers, especially human hair, according to which the coloring agent containing at least one compound of formula (I)

and/or its enaminone form

and

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,

X-means physiologically acceptable anion,

together with at least one used as a component in an aldehyde selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde, and common cosmetic ingredients applied to the containing keratin fibers, for a time, usually from about 15 to 30 minutes, left on the fibers, after which wash or washed ox is the Korean people's army shampoo. During the contacting coloring tools with fibers may be preferred application of heat, contributing to the coloring process. Heat can be provided from an external source, for example, together with sent by the fan warm air, and, above all when coloring hair on live subjects, due to their body temperature. In the latter case, on the painted area is usually put on a cap.

Thus the compounds of formula (I) and the compounds used as component B, above all, by the above preferred or particularly preferred representatives, is applied to the hair as dye components simultaneously or sequentially, that is, in multiple steps, and it does not matter which of the components is applied first. If necessary used ammonium salts or metal salts can be added as compounds of formula (I)and the compounds used as component C. the Period of time between application of the individual components can be up to 30 minutes. It is also possible pre-treatment of the fibers with a solution of a specified salt.

Before applying the proposed invention coloring tools proposed in the invention method may require pre-treatment subject to paint containing ker the tin fiber. Such pre-processing and application of the proposed invention coloring tools should not be performed directly after each other, and the corresponding operations must be separated by a time interval, the duration of which should not exceed two weeks. Suitable are several methods of pre-treatment of the fibers. Before applying the proposed invention coloring tools fiber is preferably subjected to

V1 discoloration or

V2 oxidative dyeing.

In accordance with the method of V1 contains keratin fibers treated with decolorizing agent. A similar tool in addition to an oxidizing agent, such as a conventional hydrogen peroxide, preferably contains at least one inorganic Persol, effective as of the amplifier oxidation and bleaching, for example, such as peroxodisulfate sodium, potassium or ammonium. Thanks to the implemented method V1 pre-treatment of fibres obtained proposed in the invention is a method of painting a distinctive brilliance and intensity.

In accordance with the method V2 coloring agent containing the above source products for oxidative dyes in the form of manifesting component and, if necessary, used ceskobratrska component, and when dealing with the above derivatives of indole, accordingly, indoline, applied on the fiber and after a certain time exerted on the hair impacts, if necessary with the addition of the above suitable oxidizing agents leave for containing keratin fibers for a time from 5 to 45 minutes. Then the hair is washed. The subsequent application of the proposed invention coloring tools available oxidative colourings can give the new color shade. Provided that the hue proposed in the invention coloring tools similar to the hue of the preceding oxidation dyeing, staining proposed in the invention method allows you to restore the existing oxidative coloring. Found that the Shine and the colour intensity when it is repaired or nuance proposed in the invention method exceed those achieved using only traditional direct dyes.

If the remedy for hair coloring along with compounds of formula (I) and the compounds used as component B, optionally contains as an oxidizing agent is hydrogen peroxide or a mixture of oxidizing agents including hydrogen peroxide, pH containing hydrogen peroxide hair colouring preferably the composition is scored from 7 to 11, particularly preferably from 8 to 10. The oxidizing agent can be mixed with a means for coloring the hair immediately before use and apply the mixture on the hair. In two-stage application of the compounds of formula (I) and a component In hair oxidizing agent should be applied at one of these stages, together with the respective dye component. Given this, it may be preferable packaging oxidizing agent in a common container with one of the dye components.

The compounds of formula (I) and the compounds used as component B, can be stored separately or together, in the form of a preparation from liquid to pasty (aqueous or anhydrous) or in the form of a dry powder. When the joint storage of components in the form of liquid preparation for the removal of their interaction, they must be in the most dehydrated state. Independent storage of reactive components are thoroughly mixed with each other until immediately before use. When stored in a dry state to the components before use usually add a certain amount of warm water (temperature between 30 and 80°C) and stirred to form a homogeneous mixture.

The fourth object of the present invention is the use of at least one compound f is rmula (I)

and/or its enaminones form,

and

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,

X-means physiologically acceptable anion,

together with at least one aldehyde used as a component, selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde,

for nuances of oxidative colouring containing keratin fibers, especially human hair. In such an application the moment the nuances (do it simultaneously with the oxidative dyeing or oxidation dyeing precedes the nuance) has no value.

The fifth object of the present invention is the use of at least one of the compounds of formula (I)

and/or enamines the second form,

and

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,

X-means physiologically acceptable anion,

together with at least one aldehyde used as a component, selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-methoxybenzaldehyde, 4-diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde,

to restore a painting containing keratin fibers, dyed with oxidative coloring agents.

Coloring containing keratin fibers, are known to be susceptible to environmental influences such as light, rubbing and washing, and therefore, can lose its Shine and intensity. In the worst case, when known conditions is offset from the hue. Upon customer's request color such subjected to aging of paints containing keratin fibers by restoring can change the ü thus, so it was again about the same as it was immediately after the initial staining. According to the invention for such color restoration should use a combination of at least one of the compounds of formula (I) at least one compound used as component C.

The sixth object of the present invention are the compounds of formula (I)

in which

R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group, and

X-means physiologically acceptable anion.

Preferred and particularly preferred substituents R and X-in the compounds of formula (I) such as described for the first object of the present invention.

Especially preferred are compounds of the formulas (II-1)to(II-12):

Examples

1.0 the Synthesis of derivatives of 1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine

Example of synthesis 1

1.1. Getting 1,4,6-trimethylpyridine-2(1H)-it

20,0 g (0,262 mol) of N-methylcarbamate and 29.4 g (0,291 mol) of acetylacetone were co-dissolved in 100 ml of absolute ethanol. Then were added to 97 g of concentrated sulfuric acid: this was accompanied by heating of the reaction mixture. Then the reaction mixture for one hour was stirred at room temperature. A short time later fell precipitate of hydrosulphate of the target product as a bright crystalline solid, which was isolated by filtration. Selected hydrosulphate salt was dissolved in a small amount of water and the resulting aqueous solution was neutralized 10%sodium hydroxide. Then the solution was shaken with chloroform and dried, the solvent over magnesium sulfate. After removal of the solvent in the rotary evaporator was obtained the desired product as pale pink crystals.

Melting point: 58-60°C (63°C by William J. Hale, J. Chem. Soc., 1914, 36, 104-115).

Output: 23,6 g (65.2 percent).

1H-NMR (400 MHz, DMSO-d6): δ [mn-1]=2,19 (s, 3H); 2,30 (s, 3H); to 3.38 (s, 3H); 6,24 (s, 1H).

1.1.2 Obtaining bromide, 1-allyl-1,2-dihydro-3, 4, 6-trimethyl-2-oxo-pyrimidine

A mixture of 8.0 g (0,058 mol) 1,4,6-trimethylpyridine-2(1H)-she and 14.0 g (0,116 mol) of allylbromide in acetonitrile for 16 hours was heated under reflux in an atmosphere of inert gas. After cooling, the reaction mixture fell precipitate as solids purple t the ETA, who sucked out on the filter. The product was subjected to purification by recrystallization from a mixture of chloroform diethyl ether.

Melting point: 187-191°C.

Yield: 11.7 g (77,8%).

1H-NMR (400 MHz, DMSO-d6): δ [mn-1]=2,63 (s, 3H); 2,69 (s, 3H); to 3.67 (s, 3H); 4.75 in (d, 2H); 5,72-5,80 (2×dd). 2H); 5,85-6,01 (m, 1 H); to 7.09 (s, 1H).

Example of synthesis 2

1.2.1 Synthesis is similar to the first stage 1.1.1 synthesis according to example 1.

1.2.2 Getting bromide 1,2-dihydro-1-(3-hydroxypropyl)-3,4,6-trimethyl-2-oxopyrimidine

A mixture of 10.0 g (0,072 mol) 1,4,6-trimethylpyridine-2(1H)-she and 20.6 g (0.144 mol) of 3-bromopropane in acetonitrile for 16 hours was heated under reflux in an atmosphere of inert gas. After cooling, the reaction mixture fell precipitate in the form of a light pink solid (educt), which was pumped out on the filter. The filtrate was mixed with chloroform, after which was added the same amount of diethyl ether. Received target product in the form of oil.

Output: 15,4 g (77,4%).

1H-NMR (400 MHz, DMSO-d6): δ [mn-1]=1,72 is 1.86 (m, 2H); 2,53 (s, 3H); 2,73 (s, 3H); 3,47 (t, 2H); the 3.65 (s, 3H); 4,18 (t, 2H); 7,11 (s, 1H).

Example of synthesis 3

3.1.1 Obtaining 4,6-dimethyl-1-(2-hydroxyethyl)pyrimidine-2(1H)she

To a mixture of 10.0 g (0,091 mol) of 2-(hydroxyethyl)urea and 36.9 g (0,365 mol) of acetylacetone in 140 ml of ethanol was added dropwise 13 g concentrated with what Laney acid. After addition the reaction mixture for 9 hours was heated at 70°C. after About 1.5 hours initially clear reaction solution was Motel and began the precipitation of the desired product. After cooling the reaction mixture from it by filtration was isolated solid, which was dissolved in water. The pH of the obtained aqueous solution was set in the range from 6 to 7 by adding dilute sodium hydroxide solution in a rotary evaporator under reduced pressure, water was removed and the residue was transferred to acetonitrile. The organic phase was separated from the remaining solids (NaCl) filtered and freed from solvent in a rotary evaporator. Received target product as a white powder.

Melting point: 138-140°C (139-141°C by V.S. Reznik and others, Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal), 2001, 35(12), 672-676).

Output: 10.7 g (69%).

1H-NMR (400 MHz, DMSO-d6): δ [mn-1]=of 2.21 (s, 3H); 2,43 (s, 3H); 3,62 (t, 2H); 6,36 (s, 1H).

3.1.2 Obtaining 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxopyrimidine-p-toluensulfonate

A mixture of 9.2 g (by 0.055 mol) of 4,6-dimethyl-1-(2-hydroxyethyl)pyrimidine-2(1H)-she and 13.1 g (0,068 mol) of a compound methyl ester p-toluene-sulfonic acids in 700 ml of acetonitrile for 12 hours was heated under reflux in an atmosphere of protective Gasol cooling to about 2/3 of the solvent was removed in a rotary evaporator, the residue was mixed with the same amount of diethyl ether and cooled to 0°C. the Cooling was accompanied by the separation of oil, which after some time crystallized. The crystalline product was isolated by filtration.

Melting point: 110-115°C.

Output: 17.1 g (88%).

1H-NMR (400 MHz, DMSO-d6): δ [mn-1]=and 2.26 (s, 3H); 2,62 (s, 3H); to 2.74 (s, 3H); to 3.67 (s, 3H); of 3.77 (t, 2H); 4,19 (t, 3H); 7.03 is (s, 1H); for 7.12 (d, 2H); 7,47 (d, 2H).

2.0 Preparation of coloring tools

The preparation of an aqueous gel component And Gel 1:

CH-acidic compound (component a)10 mmol
Natrosol HR 2502 g
Water (subjected to the full abating)to 100 g

First, under stirring in a small amount of water dissolved CH-acidic compound (component a), then add water up to 98, With stirring, add Natrosol and waiting for the necessary thickening.

The preparation of an aqueous gel component In the Gel 2:

Carbonyl compound (component b)10 mmol
Natrosol HR 2502 g
NaOH (50%aqueous solution)a few drops of
(if necessary)
Water (subjected to the full abating)to 100 g

Carbonyl compound (component b) is dissolved, respectively, suspended in a small amount of water. To improve the solubility if necessary, perform alkalization, adding a few drops of 50%sodium hydroxide solution. Then add water up to 98 g and carry out stirring until complete dissolution of carbonyl compounds (sometimes weak when heated to approximately 40°C). Then with stirring, add Natrosol and wait until the swelling.

3.0 Dyeing

To prepare egalitarian strands strands of human hair company Kerling (0.5 g, natural grey hair) tied in the middle and one half (upper part) was subjected to bleaching. The other half of the strands (bottom) double-bleached and subjected to two traditional perming, using designed for ordinary permanent commercial product Poly Lock. At the first stage of Curling hair for 30 minutes at room temperature was subjected to a reducing solution (containing 7.9 wt.% thioglycolic), washed with h the stand with water and then for 10 minutes at room temperature recorded oxidizing solution, containing 2.6 wt.% of hydrogen peroxide. After the oxidative treatment of hair newly washed and dried.

As described in paragraph 2.0 of the formulations prepared aqueous gels (gel 1 and gel 2), which contained the original products for dyes in accordance with table 1 combinations. Mixed both gel mass ratio of 1:1 and using ammonia, respectively, tartaric acid, set the pH of the mixture at level 9. The initial products for dyes combined, as shown in table 1.

Ready-to-use tool for coloring inflicted on egalitarian strands of hair (mass mixing ratio of gel to the hair in the dye bath was 2:1) and evenly distributed using the applicator. After carried out at 32°C With 30-minute exposure means for coloring the strands were washed with warm water and dried in a current of warm air (30 to 40°C). Thanks to the use proposed in the invention of initial products for dyes received intensive and possessed of the splendour of colouring. The obtained hue shown in table 1.

The compounds used as component (table 1):

A1 1,2-dihydro-1,3,4-trimethyl-2-oxopyrimidine (not in accordance with the invention),

A2 1,2-dihydro-1,3,4,6-tetramethyl-2-oxopyrimidine (in accordance with ISO what rutenium),

A3 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine (according to the invention),

A4 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxopyrimidine-p-toluensulfonate (according to the invention).

The compounds used as component (table 1):

B1 4-hydroxy-3-methoxybenzaldehyde (vanillin),

B2 3,5-dimethoxy-4-hydroxybenzaldehyde,

B3 4-hydroxy-1-naphthaldehyde,

B4 4-hydroxy-2-methoxybenzaldehyde,

B5 3,4,5-trihydroxybenzaldehyde,

B6 3,4-dihydroxy-5-methoxybenzaldehyde,

B7 2,4-dimethoxybenzaldehyde (not in accordance with the invention),

B8 4-hydroxybenzaldehyde (not in accordance with the invention).

td align="center"> A2
Table 1
Component a (gel 1)Component (gel 2)HueAccording to the invention
A1B1PurpleNo
A1V7YellowNo
A1B8Orange-redNo
B1PurpleNo
A2B2BlueNo
A2B4RedNo
A3B1Bright purpleYes
A3B2Intense blueYes
A3B3Intense blueYes
A3B4Bright redYes
A3B5Intense blueYes
A3B6Intense blueYes
A4B1Bright purple
A4B2Intense blueYes
A4B3Bright purpleYes
A4B4Bright redYes

4.0 Determination of resistance to washing

After made under paragraph 3.0 staining egalitarian strands of hair with a colorimeter of the type Spectralflash 450 firm Datacolor determined their colorimetric characteristics. Performed four dimensions for the top and four dimensions for the bottom strands. To simulate the washing process strands for 15 minutes was placed in full 1%solution Texapon-NSO-UP ultrasonic bath company Elma (type T 790/H, step 5). After drying again performed colorimetric measurement, as specified above.

Index dE used to assess the resistance of paint to wash, calculated on the basis of measured for the corresponding part strands of colorimetric parameters L, a, b by the equation:

dE=[(Li-L0)2+(ai-a0)2+(bi-b0)]1/2,

where L0and0and b0are respectively the average values of color the metric parameters from the results of four measurements, made before leaching, a L0and0and b0the corresponding mean values after washing.

Thus, the larger the value of dE, the lower the resistance of colouring hair to wash. Indicators of dE are shown in table 2. Coloring obtained using the proposed invention the combination of components a and b have a higher resistance to washing in comparison with the combinations according to the prior art.

The compounds used as component (table 2):

A1 1,2-dihydro-1,3,4-trimethyl-2-oxopyrimidine (not in accordance with the invention),

A2 1,2-dihydro-1,3,4,6-tetramethyl-2-oxopyrimidine (not in accordance with the invention),

A3 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine.

The compounds used as component (table 2):

B1 4-hydroxy-3-methoxybenzaldehyde (vanillin),

B2 3,5-dimethoxy-4-hydroxybenzaldehyde,

B3 4-hydroxy-1-naphthaldehyde,

B4 4-hydroxy-2-methoxybenzaldehyde.

Table 2
Component a (gel 1)Component (gel 2)dEAccording to the invention
Top the art strands The lower part of the strands
A1B19,334,3No
A2B13,54,0No
A2B24,84,1No
A2B47,92,0No
A3B11,81,7Yes
A3B21,62,5Yes
A3B33,75,6Yes
A3B41,11,7Yes

5.0 determination of the lightfastness

OCD is high in paragraph 3.0 strands of hair within 120 hours were irradiated with a xenon lamp according to DIN 54004 (color temperature 5500-6500 K, the wavelength ranges: UV-a range 300-400 nm, the visible range of 400-700 nm). After irradiation performed a visual assessment of the color of the strands when illuminated by the fluorescent lamp. The colour intensity was assessed on a scale from 1 to 6 points. Score 6 points meant a very high light fastness, 1 point - very low light fastness. The results of the evaluation of light fastness are shown in table 3. Obtained according to the invention of color had significantly higher light fastness as compared with the prior art.

Table 3
Component a (gel 1)Component (gel 2)The lightfastness, pointsAccording to the invention
A1V71-2No
A1B81-2No
A3B55-6Yes
A3B66Yes

The connection used is as component (table 3):

A1 1,2-dihydro-1,3,4-trimethyl-2-oxopyrimidine (not in accordance with the invention),

A3 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine.

The compounds used as component (table 3):

B5 3,4,5-trihydroxybenzaldehyde,

B6 3,4-dihydroxy-5-methoxybenzaldehyde,

B7 2,4-dimethoxybenzaldehyde (not in accordance with the invention),

B8 4-hydroxybenzaldehyde (not in accordance with the invention).

1. Means for containing coloring keratin fibers, especially human hair, containing, as component a at least one compound of formula (I)

and/or its enaminone form
moreover, R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group,
X-means physiologically acceptable anion,
and as a component in at least one aldehyde selected from the group comprising 4-hydroxy-3-methoxybenzaldehyde, 3,5-dimethoxy-4-hydroxybenzaldehyde, 4-hydroxy-1-naphthaldehyde, 4-hydroxy-2-methoxybenzaldehyde, 3,4-dihydroxy-5-methoxybenzaldehyde, 3,4,5-trihydroxybenzaldehyde, 3,5-dibromo-4-hydroxybenzaldehyde, 4-hydroxy-3-nitrobenzaldehyde, 3-bromo-4-hydroxybenzaldehyde, 4-hydroxy-3-methylbenzaldehyde, 3,5-dimethyl-4-hydroxybenzaldehyde, 5-bromo-4-hydroxy-3-IU is oxybenzaldehyde, 4 diethylamino-2-hydroxybenzaldehyde and 4-dimethylamino-2-methoxybenzaldehyde.

2. The tool according to claim 1, wherein R in the formula (I) denotes allyl, 3-hydroxypropyl, 2-hydroxypropyl, 2-hydroxyethylene or benzyl group.

3. The tool according to claim 1, wherein X-means halide, bansilalpet, p-toluensulfonate, alkanesulfonyl with 1-4 carbon atoms, triftorbyenzola, perchlorate, 0.5 sulfate, hydrosulfate, tetrafluoroborate, hexaphosphate or tetrachlorozincate.

4. The tool according to claim 1, characterized in that the compound of formula (I) is chosen from the group comprising physiologically acceptable salts of 1-allyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(2-hydroxyethyl)-3,4,6-trimethyl-2-oxopyrimidine, 1,2-dihydro-1-(3-hydroxypropyl)-3,4,6-trimethyl-2-oxopyrimidine and 1-benzyl-1,2-dihydro-3,4,6-trimethyl-2-oxopyrimidine and enaminone forms of these salts.

5. The tool according to claim 1, characterized in that it further comprises as a component With at least one compound selected a) CH-acidic compounds different from the compounds of formula (I) according to claim 1, and/or (b) of reactive carbonyl compounds, different from that used as a component in compounds according to claim 1.

6. The tool according to claim 5, characterized in that the CH-acidic compounds used as the component is enta, selected from the group formed with physiologically acceptable anion salt of 1,4-dimethylaniline, 1-ethyl-4-methylinosine, 1-ethyl-2-methyl-quinoline, 1,2,3,3-tetramethyl-3H-indole, 2,3-dimethylbenzothiazole, 2,3-demethylate[1,2-d]thiazole, 3-ethyl-2-methylnaphtho[1,2-a]thiazole, 3-ethyl-2-methylbenzoxazolium, 1,2,3-trimethylhexane, 3-ethyl-2-methylbenzothiazole, 1,2-dihydro-1,3,4,6-tetramethyl-2-oxopyrimidine, 1,2-dihydro-1,3,4-trimethyl-2-oxopyrimidine, 1,2-dihydro-4,6-dimethyl-1,3-dipropyl-2-oxopyrimidine, 1,2-dihydro-1,3,4,6-Tetra-methyl-2-dioxopyrimidine, 1,2-di-hydro-1,3,4,5,6-Penta-methyl-2-oxo-pyrimidine, 2,5-dimethyl-3-(2-propenyl)-1,3,4-thiadiazole, 3-ethyl-2,5-dimethyl-1,3,4-thiadiazole, 1,2-dimethylaniline, 1,3 .3m-trimethyl-2-methyleneindoline (the Foundation Fisher), oxindole, 3-methyl-1-phenyl-pyrazolin-5-she indan-1,2-dione, indan-1,3-dione, indan-1-it, 2-amino-4-imino-1,3-diazolidinylurea, benzoylacetonitrile, 3-dicyanomethylene-1-it, 2-(2-furanol)acetonitrile, 2-(2-thenoyl)acetonitrile, 2-(lanmeter)benzimidazole, 2-(cyan-methyl)benzothiazole and 2-(2,5-dimethyl-3-furanol)acetonitrile.

7. The tool according to claim 5, characterized in that the reactive carbonyl compounds used as component C, is chosen from the group comprising coniferious aldehyde, 2-methoxybenzaldehyde, 3-methoxybenzaldehyde, 4-methoxybenzaldehyde, 2-ethoxybenzaldehyde, 3-ethoxybenzene the ID, 4-ethoxybenzaldehyde, 4-hydroxy-2,3-dimethoxybenzaldehyde, 4-hydroxy-2,5-dimethoxybenzaldehyde, 4-hydroxy-2,6-dimethoxybenzaldehyde, 4-hydroxy-2-methylbenzaldehyde, 4-hydroxy-2,3-dimethylbenzaldehyde, 4-hydroxy-2,5-dimethylbenzaldehyde, 4-hydroxy-2,6-dimethylbenzaldehyde, 3,5-diethoxy-4-hydroxybenzaldehyde, 2,b-diethoxy-4-hydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 2-hydroxy-4-methoxybenzaldehyde, 2-ethoxy-4-hydroxybenzaldehyde, 3 ethoxy-4-hydroxybenzaldehyde, 4-ethoxy-2-hydroxybenzaldehyde, 4-ethoxy-3-hydroxybenzaldehyde, 2,3-dimethoxybenzaldehyde, 2,4-dimethoxybenzaldehyde, 2,5-dimethoxybenzaldehyde, 2,6-dimethoxybenzaldehyde, 3,4-dimethoxybenzaldehyde, 3,5-dimethoxybenzaldehyde, 2,3,4-trimethoxybenzaldehyde, 2,3,5-trimethoxybenzaldehyde, 2,3,6-trimethoxybenzaldehyde, 2,4,6-trimethoxybenzaldehyde, 2,4,5-trimethoxybenzaldehyde, 2,5,6-trimethoxybenzaldehyde, 2-hydroxybenzaldehyde, 3-hydroxybenzaldehyde, 4-hydroxybenzaldehyde, 2,3-dihydroxybenzaldehyde, 2,4-dihydroxybenzaldehyde, 2,4-dihydroxy-3-methylbenzaldehyde, 2,4-dihydroxy-5-methylbenzaldehyde, 2,4-dihydroxy-6-methylbenzaldehyde, 2,4-dihydroxy-3-methoxybenzaldehyde, 2,4-dihydroxy-5-methoxybenzaldehyde, 2,4-dihydroxy-6-methoxybenzaldehyde, 2.5-dihydroxybenzaldehyde, 2,6-dihydroxybenzaldehyde, 3,4-dihydroxybenzaldehyde, 3,4-dihydroxy-2-methylbenzyl egid, 3,4-dihydroxy-5-methylbenzaldehyde, 3,4-dihydroxy-6-methylbenzaldehyde, 3,4-dihydroxy-2-methoxybenzaldehyde, 3,5-dihydroxybenzaldehyde, 2,3,4-trihydroxybenzaldehyde, 2,3,5-trihydroxybenzaldehyde, 2,3,6-trihydroxybenzaldehyde, 2,4,6-trihydroxybenzaldehyde, 2,4,5-tri-hydroxybenzaldehyde, 2,5,6-trihydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-diethylaminobenzaldehyde, 4-dimethylamino-2-hydroxybenzaldehyde, 4-pyrrolidineethanol, 4-morpholino-benzaldehyde, 2-morpholinomethyl, 4-piperidinemethanol, 3,5-dichloro-4-hydroxybenzaldehyde, 4-hydroxy-3,5-disadvantange, 3-chloro-4-hydroxybenzaldehyde, 5-chloro-3,4-dihydroxybenzaldehyde, 5-bromo-3,4-dihydroxybenzaldehyde, 3-chloro-4-hydroxy-5-methoxybenzaldehyde, 4-hydroxy-3-iodine-5-methoxybenzaldehyde, 2-methoxy-1-naphthaldehyde, 4-methoxy-1-naphthaldehyde, 2-hydroxy-1-naphthaldehyde, 2,4-dihydroxy-1-naphthaldehyde, 4-hydroxy-3-methoxy-1-naphthaldehyde, 2-hydroxy-4-methoxy-1-naphthaldehyde, 3-hydroxy-4-methoxy-1-naphthaldehyde, 2,4-dimethoxy-1-naphthaldehyde, 3,4-dimethoxy-1-naphthaldehyde, 4-dimethylamino-1-naphthaldehyde, 2-nitrobenzaldehyde, 3-nitrobenzaldehyde, 4-nitrobenzaldehyde, 4-methyl-3-nitrobenzaldehyde, 3-hydroxy-4-nitrobenzaldehyde, 5-hydroxy-2-nitrobenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde, 2-hydroxy-3-nitrobenzaldehyde, 2-fluoro-3-nitrobenzaldehyde, 3-methoxy-2-nitrobenzamide the ID, 4-chloro-3-nitrobenzaldehyde, 2-chloro-6-nitrobenzaldehyde, 5-chloro-2-nitrobenzaldehyde, 4-chloro-2-nitrobenzaldehyde, 2,4-dinitrobenzaldehyde, 2,6-dinitrobenzaldehyde, 2-hydroxy-3-methoxy-5-nitrobenzaldehyde, 4,5-dimethoxy-2-nitrobenzaldehyde, 6-nitropiperonyl, 2-nitropiperonyl, 5-nitrovanillin, 2,5-dinitrosalicylic aldehyde, 5-bromo-3-nitrosalicylic aldehyde, 4-nitro-1-naphthaldehyde, 2-nitromalonic aldehyde, 3-nitromalonic aldehyde, 4-nitromalonic aldehyde, 4-dimethylaminomethyl aldehyde, 2-dimethylaminobenzaldehyde, 2-chloro-4-dimethylaminobenzaldehyde, 4-dimethylamino-2-methylbenzaldehyde, 4-diethylaminomethyl aldehyde, 4-dibutylaminoethanol, 4-diphenylacetaldehyde, 4-(1-imidazolyl)-benzaldehyde and piperonal.

8. The tool according to claim 5, characterized in that the content of compounds of formula (I), compounds used as component B, and compounds used as component C, respectively, is from 0.03 to 65 mmol, primarily from 1 to 40 mmol per 100 g of the total coloring tools.

9. The tool according to claim 1, characterized in that it further comprises a power color selected from the group comprising piperidine, piperidine-2-carboxylic acid, piperidine-3-carboxylic acid, piperidine-4-carboxylic acid, pyridine, 2-hydroxypyridine, 3 hydroxypyridine, 4-hydroxypyridine, imidazo is, 1-Mei, arginine, histidine, pyrrolidine, Proline, pyrrolidone, pyrrolidone-5-carboxylic acid, pyrazole, 1,2,4-triazole, piperidine and any mixtures of these compounds.

10. The tool according to claim 1, characterized in that it additionally contains an oxidizing agent, particularly hydrogen peroxide, in an amount of from 0.01 to 6 wt.% in terms of the applied solution.

11. The tool according to claim 1, characterized in that it additionally contains at least one component exhibiting and optionally at least one krasnobryzhyy component as the starting product for the oxidation of the dye.

12. The tool according to claim 1, characterized in that it additionally contains at least one direct dye in an amount of from 0.01 to 20 wt.% in terms of total coloring agent.

13. Tool according to one of claims 1 to 12, characterized in that it further comprises anionic, zwitterionic or nonionic surfactants.

14. Applying at least one of the compounds of formula (I) according to claim 1 in combination with at least one used as a component in a compound according to claim 1 as a coloring component of hair dye.

15. Method of dyeing containing keratin fibers, especially human hair, according to which the coloring agent in one of the paragraph is.1-13, as well as the usual cosmetic ingredients applied to the containing keratin fibers, for some time, usually about 15 to 30 min, left on the fibers, after which wash or washed fibers with shampoo.

16. The method according to item 15, wherein in accordance with the two-stage method before or after application of the compounds of formula (I) according to claim 1 containing keratin fibers cause component according to claim 1, the resulting mixture is left on the fibers for a time, usually from about 15 to 30 minutes, after which wash or washed fibers with shampoo.

17. The method according to item 15 or 16, characterized in that before applying the dye means according to one of claims 1 to 13 containing keratin fibers are pre preparation comprising the bleaching agent for bleaching or dyeing oxidative coloring agent.

18. The compounds of formula (I)

in which R is allyl group, a hydroxyalkyl group with 2-6 carbon atoms or optionally substituted benzyl group, and
X-means physiologically acceptable anion.



 

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< / BR>
where Ia 4-CL; 2-o-HOC6H6; R = 6-CH3< / BR>
IB 4-CL; 2-o-HOC6H4; R = 6-CF3< / BR>
IB 4-Cl; 2-o-HOC6H4; R = 6-C6H5< / BR>
Iك 4-Cl; 2-o-HOC6H4; R = 5-CN

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If 4-Cl; 2-o-HOC6H4; R = H

Z 4-Cl; 6-o-HOC6H4; R = H

AI 2-Cl; 4-o-HOC6H4; R = H

IC 2-Cl; 4-o-HOC6H4; R = 6-C6H5< / BR>
IIa R = H

IIb R = 4' -OC3H7< / BR>
IIb R = 5' -Br

G R = 5' -NO2< / BR>
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IIIa R = H is used as intermediate products in the synthesis of universal stabilizers for polyethylene, i.e

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents method of treating hair loss involving introduction to an indigent person of an amount of alkyl ester of nicotinic acid with alkyl group with direct chain or branched chain containing approximately 6 to 22 CH2 groups in sufficient to decrease or to terminate hair loss in said person.

EFFECT: invention provides stimulation of hair follicle with favourable therapeutic effect for hair growth disorder, such as female alopecia.

8 cl, 2 ex, 2 tbl, 2 dwg

FIELD: medicine.

SUBSTANCE: invention refers to dentistry, namely to an oral antiplaque composition, containing an orally acceptable carrier and an antibacterial effective amount of compound of formula (I). The tooth-paste or gel composition containing at least one moistening agent and at least one abrasive compound, and the oral antiplaque composition. Method of inhibiting bacterial growth in an animal's oral cavity by applying the antibacterial composition including the compound of formula (I) on the surface of the animal's oral cavity.

EFFECT: declared composition shows high antibacterial efficiency.

25 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly cosmetics. An antiperspirant composition contains emulsion "water-in-oil" containing a continuous oil phase and a dispersed aqueous phase. The oil phase contains: cyclomethicone(-s) with an ignition point 100°C or less, a silicone surface-active substance, a non-siliconised organic solubiliser of flavouring agents. The aqueous phase contains glycine-containing antiperspirant active salt or aluminium, or aluminium and zirconium provided that metal/Cl ratio in salt is within 0.9-1.3:1, glycine/Zr ratio is > 1.2, and peak-5/peak-3 ratio is > 1.0; and if aluminium salt is used, then the molar ratio of aluminium to chloride is within 0.5-2.5:1, and the molar ratio of glycine/A1 is within 0.05-0.26:1; the ratio calculated by formula: (area of peak-5)/(total area for peaks 2+3+4+5) makes at least 0.50. The composition represents a transparent emulsion and does not contain elastomers, borate cross-linking agents, saponification agents, gelling agents and auxiliary water-soluble surface-active substances.

EFFECT: invention provides effective antiperspirant action and does not leave white and sticky traces.

27 cl, 3 tbl, 25 ex

FIELD: medicine.

SUBSTANCE: external skin preparation contains as active components a ferrous compound and a compound chosen from 5-aminolevulin acid, salt of 5-aminolevulin acid, ester of 5-aminolevulin acids, ester of salt of 5-aminolevulin acids, N-acyl-5-aminolevulin acids, salts of N-acyl-5 aminolevulin acid and ester of N-acyl-5-aminolevulin acid. The ferrous compound is chosen from iron (II) citrate, sodium-iron citrate, ammonium-iron citrate, iron acetate, iron oxalate, iron (II) succinate, sodium-iron succinate and citrate, iron (II) pyrophosphate, iron (III) pyrophosphate, heme iron, iron dextrane, iron lactate, iron (II) gluconate, sodium-iron diethylene triaminepentaacetate, ammonium-iron diethylene triaminepentaacetate, ethylenediaminetetraacetate sodium-iron ethylene aminpentaacetate, ammonium-iron ethylene aminpentaacetate, iron triethylene tetraamine, sodium-iron dicarboxymehtyl glutamate and ammonium-iron dicarboxymehtyl glutamate.

EFFECT: improved skin look, prevention or reduction of roughness, dryness, wrinkles, flabbiness, and pigment spots, efficient for atopic dermatitis.

16 cl, 2 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

Protective cream // 2380088

FIELD: medicine.

SUBSTANCE: invention concerns cosmetology and represents a protective cream containing soap, a mineral vehicle, a preserving agent and water, differing that it contains potassium phytogenesis soap, kaolin or talc as said mineral vehicle and in addition, natural saturated and unsaturated higher fatty acids, cetyl or cetearyl alcohol, low-molecular organic acid and a biologically-active additive. The ingredients of the cream are taken in certain proportions.

EFFECT: invention provides reduction of negative effect of the cream on hand skin by reducing its pH to the level close to physiological pH of skin, and given cream can stimulate the regenerative function of skin and protect skin from other harmful non-chemical factors.

7 cl, 33 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a cosmetic composition for lips, containing at least one first polyester which can be produced by reaction of at least one polyol, containing 3 to 12 carbon atoms and 3 to 6 hydroxyl groups, at least one nonaromatic branched monocarboxyl acid chosen from the group, at least one aromatic monocarboxylic acid, chosen from the group and at least one polycarboxyl acid containing at least 2 carboxyl groups COOH, and/or cyclic anhydride of such polycarboxyl acid containing 3 to 18 carbon atoms; and at least one second polyester which can be produced by reaction of at least one polyol, containing 3 to 12 carbon atoms and 3 to 6 hydroxyl groups, at least one nonaromatic linear monocarboxyl acid chosen from the group, at least one aromatic monocarboxyl acid, chosen from the group and at least one polycarboxyl acid containing at least 2 carboxyl groups COOH, and/or cyclic anhydride of such polycarboxyl acid containing 3 to 18 carbon atoms. The first and second polyesters are in the composition in certain mass ratio.

EFFECT: invention provides stability and improved shine of deposited film.

10 cl, 9 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, more specifically to a soft aqueous composition for hair and skin cleaning that contains: i) medium-chain alkylethoxysulfosuccinate, ii) amphoteric surface-active substance, iii) long-chain alkylethoxysulfosuccinate, where long-chain alkylethoxysulfosuccinate component iii) is found in the composition in amount 0.1% to 6% of total medium-chain alkylethoxysulfosuccinate component i).

EFFECT: invention allows producing storage-stable soft cleaning compositions for hair and skin providing moistening and conditioning action.

9 cl, 6 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, more specifically to a soft aqueous composition for hair and skin cleaning that contains: i) medium-chain alkylethoxysulfosuccinate, ii) amphoteric surface-active substance, iii) long-chain alkylethoxysulfosuccinate, where long-chain alkylethoxysulfosuccinate component iii) is found in the composition in amount 0.1% to 6% of total medium-chain alkylethoxysulfosuccinate component i).

EFFECT: invention allows producing storage-stable soft cleaning compositions for hair and skin providing moistening and conditioning action.

9 cl, 6 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention concerns cosmetology and represents a cosmetic composition containing at least one silicone-polyamide copolymer, at least one volatile alcohol and, at least one thickener, where said copolymer contains at least one fragment (III) or (IV).

EFFECT: invention provides production of lubrication free or lubrication resistant compositions, as well as ensures improvement of keratinised tissue and provides improved by-touch characteristics in application and shows water resistance.

35 cl, 4 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents method of treating hair loss involving introduction to an indigent person of an amount of alkyl ester of nicotinic acid with alkyl group with direct chain or branched chain containing approximately 6 to 22 CH2 groups in sufficient to decrease or to terminate hair loss in said person.

EFFECT: invention provides stimulation of hair follicle with favourable therapeutic effect for hair growth disorder, such as female alopecia.

8 cl, 2 ex, 2 tbl, 2 dwg

FIELD: medicine.

SUBSTANCE: invention refers to dentistry, namely to an oral antiplaque composition, containing an orally acceptable carrier and an antibacterial effective amount of compound of formula (I). The tooth-paste or gel composition containing at least one moistening agent and at least one abrasive compound, and the oral antiplaque composition. Method of inhibiting bacterial growth in an animal's oral cavity by applying the antibacterial composition including the compound of formula (I) on the surface of the animal's oral cavity.

EFFECT: declared composition shows high antibacterial efficiency.

25 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly cosmetics. An antiperspirant composition contains emulsion "water-in-oil" containing a continuous oil phase and a dispersed aqueous phase. The oil phase contains: cyclomethicone(-s) with an ignition point 100°C or less, a silicone surface-active substance, a non-siliconised organic solubiliser of flavouring agents. The aqueous phase contains glycine-containing antiperspirant active salt or aluminium, or aluminium and zirconium provided that metal/Cl ratio in salt is within 0.9-1.3:1, glycine/Zr ratio is > 1.2, and peak-5/peak-3 ratio is > 1.0; and if aluminium salt is used, then the molar ratio of aluminium to chloride is within 0.5-2.5:1, and the molar ratio of glycine/A1 is within 0.05-0.26:1; the ratio calculated by formula: (area of peak-5)/(total area for peaks 2+3+4+5) makes at least 0.50. The composition represents a transparent emulsion and does not contain elastomers, borate cross-linking agents, saponification agents, gelling agents and auxiliary water-soluble surface-active substances.

EFFECT: invention provides effective antiperspirant action and does not leave white and sticky traces.

27 cl, 3 tbl, 25 ex

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