Transparent antiperspirant low-viscosity gel composition based on emulsion water-in-oil


FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly cosmetics. An antiperspirant composition contains emulsion "water-in-oil" containing a continuous oil phase and a dispersed aqueous phase. The oil phase contains: cyclomethicone(-s) with an ignition point 100°C or less, a silicone surface-active substance, a non-siliconised organic solubiliser of flavouring agents. The aqueous phase contains glycine-containing antiperspirant active salt or aluminium, or aluminium and zirconium provided that metal/Cl ratio in salt is within 0.9-1.3:1, glycine/Zr ratio is > 1.2, and peak-5/peak-3 ratio is > 1.0; and if aluminium salt is used, then the molar ratio of aluminium to chloride is within 0.5-2.5:1, and the molar ratio of glycine/A1 is within 0.05-0.26:1; the ratio calculated by formula: (area of peak-5)/(total area for peaks 2+3+4+5) makes at least 0.50. The composition represents a transparent emulsion and does not contain elastomers, borate cross-linking agents, saponification agents, gelling agents and auxiliary water-soluble surface-active substances.

EFFECT: invention provides effective antiperspirant action and does not leave white and sticky traces.

27 cl, 3 tbl, 25 ex

 

The SCOPE of the INVENTION

The present invention is directed to a highly efficient gel composition, which is not containing elastomer emulsion water in oil with high viscosity (>to 150,000 centipoise at 21°C), which contains glycine complex antiperspirant active ingredient (preferably with low metal to chloride) along with an ionisable salt of monovalent or divalent metal, reduced the number of glycols in the active phase, as well as low levels of non-volatile ingredients in the oil phase. The gel obtained as transparent products that leave less white and sticky residue, and less irritating.

BACKGROUND of INVENTION

Antiperspirant products are well known in the field. Antiperspirants on the market come in the form of various dosage forms such as sticks, semi-solid substances, soft gels, roll-on deodorants, sprays and creams. Typically, these dosage forms contain a solution of the active ingredient in a suitable solvent, a suspension of the active ingredient in the substance, which is not a solvent, or a multiphase dispersion or emulsion, in which the solution of the active ingredient dispersed in some of the continuous phase or in which the solubilized active ingredient extending t is the continuous phase.

Among the above-mentioned dosage forms stick is an example of a solid shape, and a semi-solid form and soft gel are thickened form, which can be solid or non-solid (e.g., in some conditions, the gels can be fluid). The form of stick may differ from semi-solid form, or soft gel the fact that in the case of the stick composition of the product can save the form for extended periods of time outside of the package when the product is almost never loses shape (Pets some decrease in volume due to evaporation of the solvent). To obtain soft gel or stick, you can adjust the amount of gelling or thickening means.

Soft gels or semi-solid form can be appropriately placed in containers, which have the form of a stick, but the distribution of the through holes (for example, cracks or pores) on the upper surface of the container. Semi-solid products also known as a soft stick or tool to apply by rubbing, as in this document, commonly referred to as "semi-solid form. As a reference you can give US patent No. 5102656, Kasat, U.S. patent No. 5069897, Orr, and U.S. patent No. 4937069, Shin, each of which reveals such semi-solid form, including their physical characteristics, such as viscosity and verdestein each of these three U.S. patents are incorporated herein by reference in their entirety for the purpose of describing the characteristics of semi-solid forms suitable containers for such products.

Recently there has been increased activity in the development of transparent antiperspirant sticks and soft gels, especially with getting sticks and soft gels having high efficiency (for example, by introducing into the composition of sticks and soft gels high amounts of antiperspirant active component), improved cosmetic characteristics (including a reduced number of white traces, reduced balance and reduced stickiness) and reduced ability to skin irritation (for example, getting "soft" product).

In U.S. patent No. 4944938, Potini, discloses transparent, alcohol-free, quick-drying antiperspirant and deodorant gels that are stable both at room and at elevated temperatures, do not cause burning sensations and not leave any white residue on the skin. This gel does not contain gelling agents, waxes, clays or monohydroxy alcohols containing 2-8 carbon atoms. Upon receipt of these gels as binders use a trivalent alcohols containing 3-5 carbon atoms, which act as soljubilizatory and maintain the system in a stable and transparent. Gels may contain active aluminium salt; volatile water-insoluble emollient, such as isostearate; soluble is magsaysay means, such as cetyl ether; soljubilizatory, such as propylene glycol and glycerin; volatile siloxanes; and water.

Some cellulosic substances, such as hydroxypropylcellulose, among others, are compatible with salts of polyvalent metals and are used in the manufacture of transparent lotions. However, to ensure solubilization of the active ingredient, the data cellulosic substances must contain a high percentage of water or alcohol. If the resulting compositions contain alcohol, they, in addition to the high ability to irritate the skin, are sticky and inefficient; if the resulting compositions contain water, they are sticky and long drying time.

Recently appeared on the market transparent antiperspirant soft gels (which are distributed from containers having the form of sticks), consisting of viscous emulsions with a high content of dispersed phase. Data soft gels have some advantages compared with the above sticks, especially transparent sticks on the basis of acetals, namely, that less limited selection of ingredients of the composition (for example, you can use water), and often significantly reduces the stickiness. In connection with these emulsions can be noted U.S. patent No. 4673570, Soldati, and U.S. patent No. 4900542, Parrotta et al. In these two patents Is And reveals clear gel antiperspirant compositions does not contain waxes and traditional gel-forming means comprises a volatile silicone fluid, a silicone emulsifier, additional destabilizing emulsifier, water, non-volatile emollient, the binder, the active antiperspirant component and auxiliary tools, such as perfume, dyes, and other. As a silicone emulsifier used silicone fluid cyclomethicone-dimethiconol copolyol supplied by Dow Corning Corporation under the trade name composition DOW CORNING 3225C. In particular, in paragraph 1 of U.S. patent No. 4673570 stated "approximately 10-25% by weight of cyclomethicone-Dimethicone opalisrobot fluid (or 1.0 to 2.5% in relation to the active ingredients)". The contents of these two U.S. patents are included in this description by reference in their entirety with reference to the described characteristics of the inventions.

Also of note is the publication of PCT international application) No. WO 92/05767. In this patent document discloses a transparent gel cosmetic product whose viscosity is at least approximately 50,000 centipoise at 21°C, the refractive index is in the range 1,3975-1,4025 at 21°C, and optical transparency over 50 IT values (turbidity units) at 21°C, this product is an emulsion, sostojawij aqueous phase, containing the active ingredient and the oil phase. The refractive index (measured at 5893 angstroms) water and oil phases are identical to 0.0004. The oil phase comprises an emulsifier, which, if appropriate mixed with a component of the aqueous phase gives an emulsion water in oil, and the aqueous phase contains one or more different polar components, such as water, propylene glycol, sorbitol and ethanol. The aqueous phase contains desodorante and/or antiperspirant active ingredient. The contents of this publication PCT international application) No. 92/05767 included in this description by reference in its entirety.

In U.S. patent No. 6007799 belonging to the same owner, described transparent cosmetic gels, which are emulsions of water in oil and which contain at least one binder, silicone fluids and alkoxysilane, alkyl substituted silicone surfactant.

In U.S. patent No. 5587153 and 5863525 issued Gillette, also described gel products that (1) contain silicone oil in the oil phase and (2) are not governed by the content of propylene glycol.

In U.S. patent No. 5925338 issued Gillette described transparent gel that contain the specified number of different types of silicones.

In U.S. patent No. 6419910, owned by Unilever, described gel antiperspirant the I and deodorizing composition based transparent emulsion, which includes emulsion water in oil, practically free of glycols and alcohols with short and medium chain. This composition contains 25-35% oil phase containing at least one non-volatile ester or at least one non-volatile silicone, where at least one of the ingredients soluble in the oil phase has a refractive index in the range of approximately from 1.40 to 1.45. The active phase contains a water-soluble complex pikelny component that increases the refractive index of an aqueous solution.

In U.S. patent No. 6410002 and in the patent application U.S. 2002/10051138 A1, also owned by Unilever, is described almost not containing glycols gel antiperspirant and deodorant composition based transparent emulsion in which the aqueous phase is additionally delimited by the introduction in its composition, of at least one polymer ethyleneglycol and which essentially contains no glycols and alcohols with short and medium chain.

In U.S. patent No. 6042816 described compositions on the basis of antiperspirant salts with high efficiency, containing calcium and amino acid or gidrokshikislotu methods of obtaining such compositions on the basis of antiperspirant salts with high efficiency, stable aqueous solutions of such compositions on the basis of antiperspirant salts with high efficiency, as well as compositions for topical application containing such compositions on the basis of antiperspirant salts with an increased efficiency.

In U.S. patent No. 6468512 owned by Avon, described transparent antiperspirant/desodorante gel composition. The composition is an emulsion water in oil, which has a viscosity of from about 7000 centipoise up to 25,000 centipoise and transparency from about 30 (NTU) or less. This composition contains an antiperspirant active ingredient, water, silicone gelling agent and one or more silicone oils.

In U.S. patent No. 6485716 belonging to the same owner as the present invention described transparent, not containing elastomer gel composition, comprising: (a) 0.1 to 25 wt.% antiperspirant active component with low metal to chloride in the range of 0.9 to 1.3:1; (b) 9-23,95 wt.% one or more volatile silicones having a flash point of 100°C. or less; (c) 0.05-0.5 wt.% silicone surfactant, which has the products HLB value (HLB) less than or equal to 8; (d) 30-70 wt.% water; (e) 0-50 wt.% certain water-soluble organic solvent; and (f) 0-10 wt.% a cushioning means; where the composition is a liquid gel with a viscosity in the range 5-50000 CP and the ratio of oil phase quednau phase in the range from 10:90 to 24:76.

In U.S. patent No. 6500412 belonging to the same owner as the present invention described non-stick transparent emulsion water in oil, containing: (a) 65-90 wt.% the dispersed phase containing 5-35 wt.% antiperspirant salt (calculated on anhydrous substance) with a ratio of metal:chloride in the range of 0.9 to 1.4:1; 5-15 wt.% tripropyleneglycol; and 35-70 wt.% water; and (b) 10-35 wt.% continuous phase containing 1-40 wt.% volatile silicone, which is not an elastomer; 0.1 to 5 wt.% silicone Zapolyarnoe surfactants; and 0-20 wt.% non-volatile silicone, which is not an elastomer; where the composition does not contain (1) C1-5 saturated alcohols, (2) added propylene glycol, (3) elastomeric gel-forming means (4) soap gel-forming means (5) borate gelling funds, and (6) binders, where all quantities are given in % by weight relative to the total weight of the composition.

Although there are different cosmetic gel composition including a transparent antiperspirant and desodorante compositions, there is still a need for cosmetic gel composition (e.g., transparent antiperspirant and/or desodorante gel composition, which has high efficiency compared with other products, especially with other commercially available gel product is mi. Another purpose of this invention is the provision of products, which are compared with commercially available products have (a) reduced number of white residue, (b) reduced stickiness, (c) high-profile drying, (d) reduced ability to irritate the skin. The next objective of this invention is the provision gel antiperspirant/desodorante products that do not contain oil-soluble softening agents with high refractive index (>1,420) (which due to the low volatility lead to an increase in the drying time of the gel composition). This invention provides an oil phase with a relatively low refractive index compared with other transparent gels that allows for obtaining a transparent gel to reduce the level of water-soluble organic or silicone tools with the appropriate refractive index (such as the glycols and other monatomic or multipart alcohols, an ionisable inorganic salts of monovalent or divalent metals, sugars, esters, and amino acids)used for the adjustment of the refractive indices of water (dispersed) phase and oil (continuous) phase.

BRIEF description of the INVENTION

This invention provides a transparent (>50-250 IT values (units mutes and) when 21,0°C), high-performance gel composition, which is not containing elastomer emulsion water in oil with high viscosity (>150,000 centipoise). The composition of these gels is glycinamide antiperspirant active component with low metal to chloride in the dispersion (aqueous) phase with high water content (>30 wt.%), copolyol and fragrance solubilizer funds in the continuous phase. Continuous (oil) phase of the composition does not contain silicone softening agents with high refractive index (R.I. >1,4200). The gel compositions of this invention may contain increased amounts cosmetically active ingredient (which must be added to the number, comprising at least 14 wt.%). Data cosmetic gels dry quickly due to the combination of low levels of non-volatiles in the oil phase and low levels (3,85-10 wt.%) glycols, provided that the amount of propylene glycol does not exceed 7.5 wt.%. The overall level of silicone softening agents are also regulated and is <1 wt.%. In order to equalize the refractive indices of water and oil phases and thus to obtain a transparent gel, the composition of the aqueous phase is injected salts of monovalent or divalent metals as a means of altering the refractive index.

This izobreteny which offers transparent emulsion water in oil, comprising a continuous oil phase and a dispersed aqueous phase, where:

(I) an oil phase contains:

(a) 7,0-23,3 wt.% (in particular, 9-20 wt.%) one or more cyclomethicone, having a flashpoint of 100°C. or less;

(b) 0.6 to 0.9 wt.% in terms of active component (in particular, to 0.6-0.8%) silicone surfactants with products HLB value (HLB, hydrophilic-lipophilic balance)≤8;

(c) 0.1 to 3.0 wt.% desiliconizing organic solubilizer flavouring funds (in particular, 0.5 to 2%), consisting of compatible with silicone, linear or branched hydrocarbons with molecular weight less than 1000, alkyl substituted phenyl esters in which the carbon chain length of alkyl substituent is from C-1 to C-20, and ethoxylated and/or propoxycarbonyl simple esters with carbon chain length from C-1 to C-25 and ethoxycarbonyl and/or propoxycarbonyl from 1 to 10 (for example, a member of the group consisting of hydrogenated of polyisobutene (Polyiso 250), C12-15 alkylbenzoates (FINSOLV TN) and miristinovoi simple ether PPG-3 (preferably ministerului simple ether PPG-3), which may contribute to the solubilization of aromatic oils in another completely silicone oil phase and which does not have a negative impact on the feeling on the skin and drying characteristics of the composition. E. the Tethyan characteristics sensations on the skin, such as humidity, stickiness and the residue is determined by 10-ball professional scale as on the forearm and underarm by evaluating some antiperspirant gels described in this invention, along with a commercial gel. Significant differences in the characteristics of some of the compositions described in this document, and commercial gel have a confidence level of 95%.

(d) 0-1 wt.% (in particular, 0-0,25 wt.% or 0.1 to 1.0 wt.%) silicone softening agents with low refractive index (R.I.<1,4200 at 21°C) (by definition, with the exception of the compounds described in paragraphs (a) and (b) of this section)selected from the group consisting of (i) volatile linear polydiorganosiloxane with flashpoints <100°C (preferably Dimethicone low viscosity); (ii) non-volatile linear polydiorganosiloxane with flash point >100°C; and (iii) silanols (for example, dimethiconol, such as DC and DC 9023 1501 from Dow Corning), in which one or two of the alkyl groups of the above compounds (i) or (ii) replaced by a hydroxyl group; (it should be noted that it is possible to use combinations of these silicone softening agents with a low refractive index, however, the maximum level of silicone softening agents should be <1 wt.% (for example, one of the specific embodiments of the present invention is tositsa to compositions, do not contain volatile linear silicones (for example, volatile Dimethicone) and/or non-volatile silicones).

(e) 0-5 wt.% odorants or component, masking the smell; and

(II) aqueous phase contains:

(a) 14-30 wt.% in terms of anhydrous substance (in particular, 17-30 wt.% and, more preferably 17-25 wt.%) glycinamide antiperspirant active salt or aluminum or aluminum and zirconium, so that (i) if using salt of aluminum and zirconium, the ratio of metal/Cl in salt should be low, for example from 0.9 to 1.3:1 (more preferably from 0.9 to 1.05:1); the ratio of glycine/Zr must be >1.2, and the ratio of peak-5/peak-3 must be >1,0; (ii) if using an aluminium salt, the molar ratio of aluminum to chloride should be in the range of 0.5 to 2.5:1; the molar ratio of glycine/Al should be in the range of 0.05-0,26:1 (preferably in the range of 0.05 to 0.16:1); where getinstancedata antiperspirant active salt has a pH in the range of 2-4 (in aqueous solution at a concentration of 15%) and contains no other substances that bind halides, and the ratio is calculated according to the formula below, has a value comprising at least 0,50:

(The peak area 5)/(total area under the peaks 2+3+4+5)

(b) 30-70 wt.% water (in particular, 45-65% and more preferably 50-60%);

(c) 3,85-10 wt.% (in particular, 4-8 wt.%) water-soluble pikolinos is istemi, which contains at least 0.2% propylene glycol and other pikelny component selected from the group consisting of ethylene glycol; diethylene glycol; triethylene glycol; tetraethyleneglycol; propylene glycol; dipropyleneglycol; tripropyleneglycol; 1,3-propane diol; 2-methylpropanol; methylpropanol; 1,6-hexanediol; 1,3-butanediol; 1,4-butanediol; PEG-4 through PEG-600; PPG-9 through PPG-34; neopentyl glycol; trimethylpropyl; 2,2-dimethyl-1,3-propane diol; 2,2,4,4-tetramethyl-1,3-cyclobutanediyl; and mixtures thereof, where the amount of propylene glycol does not exceed 7.5% (preferably it does not exceed 5%). (More preferred examples pikolinos component include one or more members of the group consisting of propylene glycol, dipropyleneglycol, 2-methyl-1,3-propane diol, methylpropylamine, polyethylene glycol, low molecular weight (less than 600) and mixtures of these compounds);

(d) 0.2 to 4 wt.% an ionisable, water-soluble inorganic or organic salts of monovalent or divalent metals to increase the refractive index of the active phase and the optimization level of the glycol. These salts have the formula MaXbwhere a=1 or 2 and b=1 or 2; M is a member of the group consisting of Na+1Li+1, K+1, Mg+2Ca+2, Sr+2and Zn+2and X is a member of the group consisting of chloride, bromide, iodide citrate, gluconate, lactate, glycinate, glutamate, ascorbate, aspartate, nitrate, phosphate, hydrogen phosphate, dihydrophosphate, formate, malonate, maleate, succinate, carbonate, bicarbonate, sulfate, hydrosulfate. Preferred salts are NaCl and ZnCl2.

(e) 0-5 wt.% water-soluble carbon funds with high refractive index (R.I.>1,4200)selected from the group consisting of additional quantities of glycine (which is not part of the original salt), glycerin, trimethylglycine ("Betaine"), alanine, DigiCert-7, citrate triglyceride-7, glycolate, glycerate-7, lactate of glycereth-5, lauramidopropyl, lactate of glycereth-5, glycolate, glycerate-7 and benzoate of glycereth-20 (Ethox GB-2) (for example, 0.5 to 3 wt.% funds with high refractive index selected from the group consisting of citrate triglyceride-7, glycolate, glycerate-7, lactate of glycereth-5, lauramidopropyl, lactate of glycereth-5, glycolate, glycerate-7 and benzoate of glycereth-20; or, as another example, 0.5 to 3 wt.% funds with high refractive index selected from the group consisting of additional quantities of glycine (which is not part of the original salt), glycerin, trimethylglycine and alanine;

(f) 0-10 wt.% (in particular, 0-4%) alcohol containing 2-4 carbon atoms (for example, 1-5% ethanol);

where (i) all quantities given what s in percent by weight of the total composition, (ii) the composition is an emulsion with a viscosity of more than 150,000 centipoise (for example, in the interval 150000-600000 CP, more preferably 200000-350000 CP), (iii) the ratio of oil phase to aqueous phase in the composition is in the range from 10:90 to 24:76; and (iv) the composition does not contain elastomers, borate cross-linking means, ameliausa funds, gel-forming means, an auxiliary water-soluble surfactants with HLB value ≥ 9.

In accordance with the first aspect of the present invention described above can be achieved using the emulsion of high viscosity, which comprises (1) a water phase containing water (or water and a water-soluble organic solvent as described above); antiperspirant active ingredient containing metals aluminum and zirconium, with a low ratio of M:Cl (from 0.9 to 1.3:1); and at least one salt of a monovalent or divalent metal, a combination of propylene glycol and other glycol containing two hydroxyl groups, or a polymeric glycol, where the General level picolinic elements does not exceed 10 wt. percent; and (2) an oil phase containing a volatile organic or silicone substance; the composition also contains (3) suitable silicone surfactant, such as alkoxysilane, alkyl substituted siloxane surface is chestno-active agent in an amount of 0.6 to 0.9 wt.% (in terms of active) the right to obtain a gel with high viscosity (>150000 SDR), as described above; and (4) a suitable solubilizer flavouring means, such as ministerului simple ester, which contributes to the solubilization of aromatic oils in predominantly silicone oil phase.

The refractive indices of the active phase and an oil phase consisting of fragrances, surfactants, solubilization flavouring funds and silicones) are balanced by adding glycols, salts of monovalent and divalent metals and, optionally, monohydroxy alcohols so that the refractive indices of the active phase and oil phase differ by approximately 0,000-0,0040 units. The result is a transparent product with a value (NTU, values of turbidity units) in the range from 50 to 250 and R.I. in the interval from 1,4025 to 1,4150. Most preferably, the refractive index of the active phase was lower than the refractive index of the aromatic oil phase, as it allows you to minimize the level of glycols. Added to the compositions of aromatic oils typically have a refractive index in the range 1,4450-1,4850 and are used in amounts ranging from 0.50 to 2.0 wt.%. To get a quick-drying gel composition, optimize the amount of an ionisable inorganic salts of monovalent and d is wjvalente metals, antiperspirant salts, water and additional ingredients such as alcohol.

The refractive indices measured at a temperature of approximately 20-25°C with a Refractometer Bausch and Lomb Abbe 3L. The turbidity measurement, as described herein, is performed on the c turbidity meter direct reading Orbeco-hellige in Norwegian #965.

One embodiment of the present invention relates to the composition of the oil phase, which after adding the flavouring component (if the composition add odorant) is the refractive index in the range from about 1,4015 to 1,4150; in particular, from about 1,4025 to 1,4090.

One of the advantages of adding desiliconizing organic solubilizer flavouring funds is to improve the solubility of the aromatic funds in silicon (primarily in cyclomethicone) the oil phase of the gel emulsion. The limited solubility of some of the flavors in cyclomethicone and linear polydiorganosiloxane (if present) can easily be determined by the turbidity of the above silicone (silicone) after adding thereto approximately 10-30 wt.% flavouring funds. Specialists in this field it is known that adding a small amount, for example 5-10 wt.% (the number depends on the type of flavouring agents), a solubilizer ar is matitira funds described above (for example, miristinovoi ether PPG-3), to a mixture of silicone/natural-identical flavouring allows to obtain a clear solution.

The gel compositions of the present invention with high viscosity containing antiperspirant active component in a quantity sufficient to provide a deodorizing effect, and/or in sufficient quantity to reduce sweating in humans during application of the composition. As antiperspirant active ingredient included in the composition of the dispersed (also called "active"phase, you can use different compounds having antiperspirant activity and suitable for use in the present invention, provided that they dissolve in the active phase in a suitable concentration.

Antiperspirant active compounds may be included in compositions of the present invention in quantities of, for example, are in the range of 14-30 wt.% (calculated on the anhydrous solid), preferably 17-25% wt.% in relation to the total weight of the composition. You can also use a mixture of active compounds. The amount used depends on the composition. If the number is in the upper part of the interval, you can expect a good antiperspirant effect. As indicated above, the active compound is preferably introduced into the composition of the top songs the invention by mixing the active compounds with water and perhaps with a small amount of propylene glycol.

Antiperspirant active compounds may be included in compositions of the present invention in the above number. At lower levels of antiperspirant active connection is not completely reduces perspiration, but reduces unpleasant odor, for example, acting as an antimicrobial agent. In the amount of 15-25% by weight relative to the total weight of the composition (in terms of active ingredient) can be observed antiperspirant effect.

Very preferred antiperspirant active compounds exhibiting particularly low metal to chloride mentioned above, and described in U.S. patent No. 6375937 and in a patent application owned by the same owners as the present invention (case number IR 6997, serial number USA 10/314712 filed 12/9/02).

A specific type of interest salts is aluminazirconia tetrazol glycine, where aluminazirconia tetrachlorohydrex glycine is the ratio of metal to chloride in the range from 0.9 to 1.2:1 (especially in the range from 0.9 to 1.1:1, more preferably the range from 0.9 to 1.0:1); and the molar ratio of glycine:zirconium is more than 1.2:1, preferably about 1.4:1. This type of salt can be obtained using several methods described in U.S. patent No. 6375937, as initially the tsya above.

Another specific type of interest salt is aluminum chloride, buffered glycine, in which the ratio of metal to chloride is in the range of 0.9 to 1.2:1, preferably in the range of 0.9 to 1.1:1 and more preferably in the range of 0.9 to 1.0:1). Also of interest salts, which contain betaine, an additional amount of glycine or other amino acid, such as alanine, to increase the refractive index glocestershire active complex.

Examples of salts include salts obtained in the following way:

The way A: Aqueous solution of hydrochloride of aluminum (ACH) with a suitable concentration is mixed with an aqueous solution of circinelloides (ZrOCl2) a suitable concentration and powdered glycine. The mixture is stirred at room temperature, obtaining salt.

Method B: Receive a suitable commercially available salt aluminazirconia tetrachlorohydrex glycine and mix it with a sufficient quantity of an aqueous solution of aluminum chloride (AlCl3) and powdered glycine. The mixture is stirred at room temperature, obtaining salt. Salts suitable for use as the starting material in the method include different types of tetrazole, such as aluminazirconia tetrachlorohydrex glycine, propylene glycol complex aluminazirconia those who of rechargers glycine, dipropyleneglycol complex aluminazirconia of tetrachlorohydrex glycine, and mixtures of any of the above compounds. These salts can then be called experimental, or name may be present suffix "exp". Upon receipt of the compositions of this invention experimental salt preferably used in the form of 28-50% aqueous solution.

As cyclomethicone the present invention use one or more members selected from the group consisting of cyclic polydimethylsiloxanes, such as represented by formula III:

Formula III

where n is an integer having a value of 4-6, preferably 5-6. These compounds include the tetramer (D4), pentamer (D5) and hexamer (D6), and a mixture of two or three of them. For example, you can use such cyclomethicone fluid DC-245 and DC 345 from Dow Corning Corporation (Midland, Michigan). It should be noted that for the purposes of the present invention cyclomethicone not used as a silicone softening agents.

Suitable silicone surfactants include silicone polyglucoside (for example, octylimidazolium) and silicone copolyol with products HLB value (HLB, hydrophilic-lipophilic balance) ≤8. The products HLB value can be defined in different ways, the example described in the standard manuals, or you can find them in the data table, which lists those values. It is assumed that you can use any method of determining the products HLB.

Silicone copolyol (especially dimethiconol copolyol) can be used in an amount of 0.6 to 0.9, preferably 0.6 to 0.8 wt.% (in terms of active ingredient).

Typically, silicone copolyol used in the present invention include copolyol the following formulas I and II. The substances of formula I can be represented as follows:

(R10)3-SiO-[(R11)2-SiO]x-[Si(R12)(Rb-O-(C2H4O)p-(C3H6O)s-Rc)O]y-Si-(R13)3

The formula I

where R10, R11, R12and R13may be the same or different, and each may be selected from the group consisting of C1-C6of alkyl; Rbrefers to the radical-CmH2m-; Rc denotes a terminal radical, which may be a hydrogen, alkyl group containing from one to six carbon atoms, acyl group, such as ester group with a terminal alkyl group containing 1-4 carbon atoms, or aryl group such as phenyl; m has a value from two to eight; p and s have values such that when the weight axially novogo fragment -(C 2H4O)p-(C3H6O)s- is in the range from 200 to 5000; this fragment preferably contains from fifty to one hundred mole percent oxyethylene elements -(C2H4O)pand one to fifty mole percent oxypropylene elements -(C3H6O)s-; x has a value from 8 to 400; and y has a value from 2 to 40. Preferably each of R10, R11, R12and R13denotes a methyl group; Rcdenotes H; m is preferably three or four, respectively, Rbmost preferably represents the radical -(CH2)3-; p and s have values such that when the molecular weight oxyalkylene fragment -(C2H4O)p-(C3H6O)s- is in the range from 1000 to 3000. Most preferably, each of the p and s has a value in the range from about 18 to 28.

The second siloxane simple polyester (copolyol) has the formula II:

(R10)3-SiO-[(R11)2-SiO]x-[Si(R12)(Rb-O-(C2H4O)p-Rc)O]y-Si-(R13)3

Formula II

where p has a value from 6 to 16; x has a value from 6 to 100; y has a value from 1 to 20, and the other fragments have the same definition as in formula I.

It should be understood that h is on in both of the above formulas I and II, the siloxane-oxyalkylene copolymers of the present invention in alternative embodiments may take the form of polyethers with blocked ends, in which the linking group Rb, oxyalkylene fragments and end the radical Rcmore often occupy positions associated with the ends of the siloxane chain than an atom of silicon siloxane chain. For example, one or more of the substituents R10, R11, R12and R13attached to the two terminal silicon atoms at the end of the siloxane chain can be replaced by fragment-Rb-O-(C2H4O)p-(C3H6O)S-RCor fragment-Rb-O-(C2H4O)p-RC. In some cases it is desirable that the fragment-Rb-O-(C2H4O)p-(C3H6O)S-RCor fragment Rb-O-(C2H4O)p-RCwas in the siloxane chain, and also on one or both ends of the siloxane chain.

Specific examples of suitable dimethiconol of Aprilov available, either commercially or experimentally from a number of suppliers including Dow Corning Corporation, Midland, MI; General Electric Company, Waterford, NY; Witco Corp., Greenwitch, CT; and Goldschmidt Chemical Corporation, Hopewell, VA. Examples of specific products include DOW CORNING® S from Dow Corning, which is a 10% solution dimethiconol copolyol in cyclamate the region; DOW CORNING® 2-S, which is a 45-49% solution dimethiconol copolyol in cyclomethicone; SILWET L-7622 from Witco; ABIL EM97 from Goldschmidt, which is an 85% solution dimethiconol copolyol in cyclomethicone D5; and various dimeticone copolyol, either commercially available or known from the literature.

It should also be noted that it is possible to use different concentrations dimethiconol of Aprilov in cyclomethicone. Although commercial preparations often have a concentration of 10% in cyclomethicone, you can get different concentrations by removing cyclomethicone or add additional cyclomethicone. Of particular interest are drugs with a higher concentration, such as DOW CORNING® 2-S.

In one particular embodiment can be used 3-9 wt.% (preferably 5-8%) 10% silicone copolyol, such as dimethiconol copolyol, cyclomethicone mixture, where the amount of added mixture are chosen so that the level of silicone copolyol in cosmetic compositions was in the range of 0.6 to 0.9%, preferably 0.6 to 0.8%) (for example, a 6.5% 10% dimethiconol copolyol in cyclomethicone mix).

The choice of softening funds restricted funds with a relatively low refractive index (R.I.<1,4200)to reduce the refractive index of the oil phase and thus free the th its alignment with the refractive index dispersion of the active phase. Softeners are known in the field class of substances that soften skin. Softeners are the ingredients that help keep skin soft, smooth and plastic. It is also known that softeners reduce white deposits on the skin and/or improve the aesthetic characteristics. Examples of suitable softening agents that meet the requirement of low refractive index, limited to a silicon structures that do not contain phenolic groups.

Preferably linear silicones selected from the group consisting of polydiorganosiloxane represented by the formula

(1) (R10)3SiO(Si(R11)2O)xSi(R12)3where R10, R11and R12may be the same or different and independently selected from the group consisting of C1-C10the alkyl (preferably are polydimethylsiloxane (Dimethicone), especially Dimethicone low viscosity (viscosity of < 100 SDR) (group R and x values are chosen so that RI was within the specified limits);

(2) silanol and/or dimethiconol, in which one or two of alkyl (such as methyl) groups of the above formulae may be substituted by a hydroxyl group and which is represented by the formula

HO(R14)2SiO(Si(R15)2O)xSi(R16)2 OH and

R17(R14)2SiO(Si(R15)2O)xSi(R16)2HE

where R14, R15, R16and R17may be the same or different and independently selected from the group consisting of C1-C10the alkyl (preferable example is methyl) (group R and x values are chosen so that RI was within the specified limits).

Specific examples of suitable softening agents include, but are not limited to, members of the group consisting of Dimethicone having a viscosity in the range of 0.5 to 5.0 CST (for example, Dow Corning® DC 200), dimethiconol (Dow Corning® DC1501), cosmetic wax Dow Corning 2501 (dimethiconol copolyol), dimethiconol of behenate, C30-45alkylation, starextremely and sterilisation and silanol (DC 9023, also from Dow Corning).

Emollient with low refractive index or a mixture of softening agents can be included in the compositions of the present invention, for example, the number of 0-1 wt.% inclusive, preferably 0.5 to 1%.

The oil phase of the present invention preferably is a silicone oil phase, to obtain an emulsion of water in silicone oil. The total mass of the oil phase and siloxane surface-active products is preferably from about 10% to 24% of the total weight of the composition. The surface is IDT-active agent is an emulsifier, which, if appropriate mixed with the components of the aqueous phase and the components of the oil phase gives an emulsion water in oil. Preferably the oil phase is a mixture of liquids, but does not contain any significant amount of non-volatiles (i.e. contains less than 1.0 wt.% any substance that has a flashpoint above 100°C). In addition, all softeners based on non-volatile silicone, are described in this composition, have a refractive index lower than 1,420.

Determine the refractive index of the oil phase (containing the odorant) and, if necessary, adjust it so it was in the range from about 1,4015 to 1,4150; preferably from about 1,4025 to 1,4090 determine the refractive index of the aqueous phase and adjust it (if necessary)to differentiate it from the refractive index of the oil phase is less than 0,0050, preferably less than 0,0030 units. Then the aqueous phase is mixed with an oil phase (e.g., the aqueous phase is added slowly to the oil phase with vigorous stirring and with stirring, add other additives or other active ingredients. Alternatively, the flavoring can be added after addition of the active phase to the oil phase. In this case, the refractive indices of the oil phase (no flavor) and water f the PS should vary less than 0,0020. Then, the resulting emulsion is passed, for example, through a colloid mill or other emulsifier, high shear to obtain a viscous gel that can be transferred into a suitable applicator or container for use by the consumer. In accordance with the present invention it is desirable that the aqueous phase also contained a mixture of glycols consisting of propylene glycol and 2-methylpropanol and/or dipropyleneglycol, which gives the final product the previously described advantages.

A concrete example alkoxysilanes alkyl substituted siloxane surface active agents is preferably, without limitation, dimethiconol copolyol. Example alkoxysilanes siliconsamurai surfactants used in accordance with the present invention, is acidimetry copolyol described in U.S. patent No. 5162378, Guthauser. For example, alkoxysilane, alkyl substituted surface-active agent included in the composition in amounts of from 6.0% to 9.0% by weight relative to the total weight of the composition. Another example of a suitable surfactant is octylimidazolium (from Wacker-Belsil, Adrian, MI).

Specific cyclomethicone-Dimethicone Zapolyarnoe fluid, which can be used to obtain alkoxysilane si is consolereader surface-active products, is a mixture of cyclomethicone and dimethiconol copolyol called DC5225C from Dow Corning Corporation. It is replaced by a simple polyester silicone from cyclomethicone and dimethiconol copolyol (refractive index (RI) =1,3994 at approximately 20-25°C). DC 5225C, which is an emulsifying agent, is used to obtain stable emulsions of water in oil, where the silicone is a large part of the oil phase, and is a dispersion of a silicone surfactant (dimethiconol copolyol) (10 mass%) in cyclomethicone (Dow Corning 245) (90 mass%).

The liquid mixture of cyclomethicone and dimethiconol copolyol is present in the composition, for example, in the amount of approximately 7.0% to 23.3% by weight relative to the total weight of the composition.

In accordance with another aspect of the present invention the aqueous phase of a cosmetic gel composition additionally contains a small amount pikolinos system (3,85-10 wt.%, preferably 4-8%)containing propylene glycol and preferably, at least one other glycol or polyglycol, to increase the refractive index of the active phase so that it is different from a refractive index of perfumed oil phase is not more than 0,0000-0,0040 units (preferably 0,0010-0,0030 units). For example, as another propylene glycol can is about to use tripropyleneglycol. In accordance with this aspect of the present invention, the propylene glycol can be used in combination with glycols in limited quantities. The inclusion of glycols, especially Mr-diol (2-methyl-1,3-propane diol) and dipropyleneglycol, the gel composition also improves cosmetic properties, including reducing stickiness and reduced white residue and residue after application of the composition. Moreover, the compositions containing polypropylenglycol, especially tripropyleneglycol, have increased softness (i.e. reduced ability to irritate the skin) compared with commercially available products. Glycol or polyglycol selected from the group consisting of ethylene glycol, propylene glycol, 1,2-propane diol, 2-methylpropanol, diethylene glycol, triethylene glycol, tetraethyleneglycol, dipropyleneglycol, tripropyleneglycol, methylpropanol, 1,6-hexanediol, 1,3-butanediol, 1,4-butanediol, PEG-4 through PEG-600, PPG-9 through PPG-34, neopentyl glycol, trimethylpropane, 2,2-dimethyl-1,3-propane diol, 2,2,4,4-tetramethyl-1,3-cyclobutadiene and mixtures thereof. More preferable examples of glycols that can be used with propylene glycol, are one or more members of the group consisting of dipropyleneglycol, 2-methyl-1,3-propane diol, methylpropylamine, low molecular weight (less than 600) of propylene glycol and mixtures thereof, where n is piligrims not exceed 7.5%.

Transparent gel composition of this invention also contain at least one of an ionisable inorganic salt, which increases the refractive index of the active phase and allows to optimize the level of glycol. High levels of glycols and reduces stickiness, tend to increase the drying time. Data of an ionisable salts have the formula MaXbwhere a=1 or 2, b=1 or 2, M represents a member selected from the group consisting of Na+1Li+1, K+1, Mg+2Ca+2, Sr+2and Zn+2and X denotes a member selected from the group consisting of chloride, bromide, iodide, citrate, gluconate, lactate, glycinate, glutamate, ascorbate, aspartate, nitrate, phosphate, hydrogen phosphate, dihydrophosphate, formate, malonate, maleate, succinate, carbonate, bicarbonate, sulfate, hydrosulfate. It is preferable to use NaCl and ZnCl2. Specialists in this field it is clear that, although in some cases salt can be added directly to a portion of the mixture in the production process, it is preferable to add salt in the form of a mixture, or in the form of a solution in a carrier or solvent, preferably in water. Of course, can be obtained by different salt concentrations, for example in the range of 1-40%.

The present invention also includes methods of obtaining described here cosmetic gel is o compositions of high viscosity. In such methods, an aqueous phase containing water and antiperspirant active ingredient, get separate from the oil phase containing alkoxysilane, alkyl substituted siloxane surface active agent, an organic solubilizer flavouring funds, cyclomethicone and, optionally, the odorant. Then the two phases are combined and homogenized to obtain a desired viscosity.

In one embodiment, the active phase is an aqueous phase containing from 17 to 30 wt.% (in terms of anhydrous substance) glycinamide antiperspirant active component with a low ratio of metal:chloride, 4,05-14 wt.% water-soluble pikolinos system with an ionisable water-soluble salt of a monovalent or divalent metal. For example, free water included in the composition in an amount of 30-70 wt.% in relation to the total weight of the composition. The aqueous phase optionally may contain, for example, (along with the antiperspirant active ingredient, a water-soluble pikolinos system and an ionisable salt of divalent or monovalent metal) 1-5 wt.% water-soluble carbon funds with high refractive index (preferably an additional amount of glycine (which is not part of the original salt), glycerol, alanine, and/or Betaine (as noted above, trimethylglycine)).

To the position of the present invention can be obtained by periodic way, or continuous or semi-continuous way, these methods allow to obtain stable, high-performance songs which have great aesthetic characteristics.

Compositions of the present invention is used as a traditional cosmetic gel composition. For example, if the composition of the present invention is a composition transparent antiperspirant soft gel, packaged in distributing the container, the upper surface of which contains cracks or pores, the gel is extruded from the distributing container through cracks or pores and applied to the skin (for example, the underarm region of the body by rubbing soft gel, squeezing through the top surface of the container to the skin of the armpit.

The following aspect of the present invention distributes the container can be transparent or slightly colored in accordance with the aesthetic needs. In comparison with commercially available products of the composition has a low tack, dries quickly, creates a refreshing silky feeling and when dry leaves far fewer white marks or just not leave them. Moreover, the compositions of the present invention containing propylene glycol component, have increased softness (low R & d ability is translated to the skin irritation) compared with commercially available products, have improved cosmetic properties (including reduced stickiness) and after application leave less white traces. Gel emulsion of the present invention are stable, optically transparent, and cosmetically elegant and can be delivered from a suitable applicator container.

In the present description of antiperspirant active substances for use in the antiperspirant composition in an effective amount to reduce unpleasant body odor as a result of reduced sweating; however, these antiperspirant active substances can also have a deodorizing effect, for example, as antimicrobial agents. Desodorante active substances practically reduce sweating, but reduce unpleasant smells in another way, such as perfumes, masking unpleasant odor or reduce its intensity, as odor absorbents, as antimicrobial agents, as a means of chemically interacting with substances causing odor, etc.

The amount of the active ingredient varies depending on the specific active ingredient. The product contains antiperspirant active substances in quantities sufficient to neutralize unpleasant body odor using either deodorant or antiperspirant which CSOs tools when applied to the underarm area of the body. As a rule, the antiperspirant product is supposed to contain the active antiperspirant substance in quantities of, for example, from about 9% to 25% by weight relative to the total weight of the composition. However, in the present invention it was found that to obtain the desired transparency you need to use at least 14 wt.% antiperspirant salt. The active antiperspirant substance used in the compositions of the present invention, can be pre-dissolved in water or in another solvent (e.g. propylene glycol), and the resulting solution may not necessarily be tabularity. Preferably antiperspirant substances dissolved in a solvent.

If you use desodorante active substance, different from the antiperspirant active substances in low quantities, any desodorante active substance that can be dissolved in the oil phase, can be used in a quantity sufficient to achieve a deodorizing effect. For example, deodorant active substance can be 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan) and/or chloride benzene and/or octoxyglycerin (Sensiva® SC 50). If instead of antiperspirant active ingredient use deodorizing ingredient, get the deodorizing composition of the gel (rather than antiperspirant gel composition is Yu).

In the present description, where compositions are described as including or containing specific components or substances, the inventors suggest that the composition of the present invention also essentially comprise the described components or substances. Accordingly, in the present description, any of the described composition of the present invention may essentially consist of the described components or substances.

The target characteristic of the present invention is to provide a clear cosmetic gel composition (e.g., transparent deodorant or antiperspirant gel composition). It is implied that the term transparent (i.e. transparency) in accordance with the present invention comprises the usual dictionary definition; thus, a transparent, for example, cosmetic gel composition of the present invention makes it easy to see the objects behind it. On the contrary, translucent composition allows light to pass through it, but it causes scattering of light, resulting in impossible to see objects behind the translucent composition. The optical transparency of the compositions can be measured using turbidimetry, as described above, and it is desirable that it was in the range of from 50 to 250 IT in the case of measurement at room temperature (20-25°C).

Cu is IU, clear cosmetic gel composition of the present invention, which is in the form of microemulsion, in contrast to microemulsions, must not contain wax or gel-forming means, such as milwauee tools, cellulose substances or alginates. Further, the composition of the present invention does not require the presence of polydimethylsiloxane, although the composition of the present invention may contain this substance. Contain 3-7 wt.% propylene glycol in combination with either 2-methylpropanol or dipropyleneglycol.

Some specific embodiments include embodiments that contains one or more of the following components: 1-4 wt.% ethanol or propanol; 9-20 wt.% one or more cyclomethicone; 0.6 to 0.8 wt.% silicone surfactant; 0.5 to 2 wt.% a solubilizer aromatic funds; and 45-65 wt.% water.

Various substances included in the composition of the aqueous and oil phases, and their refractive indices (measured with a Refractometer Bausch and Lomb Abbe 3L) are given in the following specific composition:

6,0-9,0 wt.% dimethiconol copolyol/cyclomethicone (10%) (for example, Dow Corning 5225C);

7-23,3 wt.%, preferably 8-15 wt.% cyclomethicone (D4, D5, D6 or their mixtures);

0.1 to 3.0 wt.% miristinovoi ether PPG-3;

17-25 wt.% antiperspirant active component (for example, Al-Zr tet is achlorhydria glycine (for example, Z-522, 27.5 per cent, from Summit Research Labs, Huguenot, NY) and dichlorhydrate aluminum (such as Westchlor 100, 36,1%, to which was added glycine so that the molar ratio of gly/Al is in the range of 0.05-0,26:1), such as described in U.S. patent No. 6375937 and patent application owned by the same owners as this invention (case # IR 6997, serial number USA 10/314712 filed 12/9/02);

30-70 wt.% water;

from 0.2 to 4.0 wt.% an ionisable salt or combinations of an ionisable salts of the formula MaXbwhere a=1 or 2; b=1 or 2; M is a member of the group consisting of Na+1Li+1, K+1, Mg+2Ca+2, Sr+2and Zn+2and X is a member of the group consisting of chloride, bromide, iodide, citrate, gluconate, lactate, glycinate, glutamate, ascorbate, aspartate, nitrate, phosphate, hydrogen phosphate, dihydrophosphate, format, malonate, maleate, succinate, carbonate, bicarbonate, sulfate and hydrosulfate (preferred salts are ZnCl2and NaCl or combinations thereof);

4-8 wt.% pikolinos system, as described above in the definition of the invention;

0-1 wt.% softening agents with low refractive index (RI<1,4200), such as dimethiconol, Dimethicone, silanol combined with caffeine and combinations thereof;

0-1,0 wt.% sage oil (any type, for example, Clary or Dalmation);

0-5 wt.% odorants or component, masking odor;

0-10% water-soluble aglialoro organization is practical solvent, selected from the group consisting of alcohols containing a chain of 2-4 carbon atoms (e.g. ethanol);

0-5 wt.% water-soluble carbon compounds with a high refractive index, such as an additional glycine, which is not part of the original salt, trimethylglycine, alanine, glycerol, diglycerol-7, citrate triglyceride-7, the glycolate, glycerate-7, lactate of glycerate 5 lauramidopropyl, lactate of glycereth-5, the glycolate, glycerate-7 and benzoate of glycereth-20;

where the ratio of oil and water phases in the composition is in the range of 10:90-25:75, and the viscosity is in the range 150000-600000 CP.

EXAMPLES

The following examples are provided to illustrate the invention and should not be construed as limiting. In the examples in the other sections of the description of the present invention, the chemical symbols and terminology have customary and traditional values. In the examples and in other sections of this application, the values n, m, etc. in the formula, molecular weight and degree of ethoxyline or propoxycarbonyl are average values. Temperatures are given in degrees C, unless otherwise noted. The number of components is given in mass percent with respect to the described standard; unless another standard is defined as the total weight of the composition. Different names chemical is of komponentov include names, listed in the CTFA International Cosmetic Ingredient Dictionary (Cosmetics, Toiletry and Fragrance Association, Inc., 7thed. 1997). The refractive index ("RI") is determined at a temperature in the range 20-25°C.

EXAMPLES 1-25

For the examples in tables A-C, you can use the following method with the specified types and quantities of ingredients. The magnitude of the samples is approximately 500 grams. Silicone copolyol, cyclomethicone and odorant weighed and combined into beaker. The mixture was stirred at 400-600 rpm using an electric mixer Lightnin Mixer Model LI003. After the mixture becomes homogeneous in appearance to the oil phase with stirring active phase containing an antiperspirant active ingredient, an ionisable salt and other ingredients (propylene glycol and diol MP). The whole mixture is stirred for 15 minutes. The mixture is then homogenized for 2-4 minutes when set to 50-70 on Powerstat Variable Transformer (Superior Electric Co., Bristol, CT) using a homogenizer from Greerco Corp. (Hudson, NH).

to 12.0
Table a
Ingredients (wt.%)Example 1Example 2Example 3Example 4Example 5
Cyclomethiconeto 12.010,7011,5010,50
Dimethiconol copolyol/cyclomethicone
(DOW Corning 5225C,
10%)
6,006,006,506,506,50
Ministerului ether2,002,001,801,002,00
Perfume1,001,001,01,01,0
The active component A*69,7069,7070,0070,00,00
The active component A**0,000,000,000,0064,6
Diol Mr3,503,500,300,0 0,00
Dipropyleneglycol0,000,000,003,554,70
Water3,302,462,703,407,80
A solution of zinc chloride
(70,5 wt.%/wt.%)
2,842,602,752,60
NaCl granules2,000,000,000,000,00
Propylene glycol0,500,504,400,300,30
* The Al-Zr tetrachlorohydrex glycine (Z522, 27.5% in water, from Summit Research Labs), which is a type of salt that is described in the above methods A and B.
** The Al-Zr tetrachlorohydrex glycine (Z522, 29.3% water, from Summit Research Labs).

1. Antiperspirant composition comprising an emulsion water in oil, comprising a continuous oil phase and a dispersed aqueous phase, where
(I) an oil phase contains:
(a) 7,0-23,3 wt.% one or more cyclomethicone, having a flashpoint of 100°C. or less;
(b) 0.6 to 0.9 wt.% silicone surfactants with the value of the hydrophilic-lipophilic balance ≤8;
(c) 0.1 to 3.0 wt.% desiliconizing organic solubilizer flavouring funds; and
(II) aqueous phase contains:
(a) 14-30 wt.% in terms of anhydrous substance glycinamide antiperspirant active salt or aluminum or aluminum and zirconium, provided that (i) if using salt of aluminum and zirconium, the ratio of metal/CL in the salt is in the range of 0.9 to 1.3:1, the ratio of glycine/Zr>1.2, and the ratio of peak-5/peak-3>1,0; and (ii) if using an aluminium salt, the molar ratio of aluminum to chloride in the range of 0.5 to 2.5:1, and the molar ratio of glycine/Al is in the range of 0.05-0,26:1; where getinstancedata antiperspirant active salt has a pH in the range of 2-4 when measured in aqueous solution at a concentration of 15%, and contains no other substances that bind halides, and the ratio is calculated according to the formula below, is C is Uchenie, forming at least 0,50:
(The peak area 5)/(total area under the peaks 2+3+4+5)
(b) 30-70 wt.% water;
(c) from 0.3 to 10 wt.% water-soluble pikolinos system, which contains at least 0.2% propylene glycol and other pikelny component selected from the group consisting of propylene glycol, dipropyleneglycol, tripropyleneglycol, 2-methyl-1,3-propane diol, 1,3-propane diol, methylpropylamine, low molecular weight polyethylene glycol and mixtures of any of these compounds, in which the amount of propylene glycol does not exceed 7.5%;
(d) 0.2 to 4 wt.% an ionisable, water-soluble inorganic or organic salts of monovalent or divalent metals of the formula MandXbwhere a=1 or 2 and b=1 or 2; M is a member of the group consisting of
from PA+1Li+1To+1MD+2, CA+2, Sr+2and Zn+2, a X is a member of the group consisting of chloride, bromide, iodide, citrate, gluconate, lactate, glycinate, glutamate, ascorbate, aspartate, nitrate, phosphate, hydrogen phosphate, dihydrophosphate, formate, malonate, maleate, succinate, carbonate, bicarbonate, sulfate, hydrosulfate;
where the composition is a transparent emulsion;
the composition has a ratio of oil phase to aqueous phase in the composition in the range from 10:90 to 24:76;
where the composition has a viscosity of more than 150,000; and
the composition is not what keeps elastomers, borate cross-linking means, spilivaya funds, gel-forming means and auxiliary water-soluble surface-active substances with products HLB value≥9.

2. The composition according to claim 1, having a viscosity in the range 150000-600000 SDR.

3. The composition according to claim 2, having a viscosity in the range 200000-350000 SDR.

4. The composition according to claim 1, where the transparency of the specified product is in the range from 50 to 250 IT at 21°C.

5. The composition according to claim 1, where the refractive index of the specified product is in the range from 1,4025 to 1,4150.

6. The composition according to claim 1, where the molar ratio of aluminum to chloride in the antiperspirant salt is in the range of 0.05-0.26 of:1.

7. The composition according to claim 1, where the molar ratio of aluminum to chloride in the antiperspirant salt is in the range of 0.05 to 0.16:1.

8. The composition according to claim 1, containing 17-25 wt.% antiperspirant active component.

9. The composition according to claim 1, where an ionisable salt selected from the group consisting of NaCl and ZnCl2.

10. The composition according to claim 1 where the water-soluble picolina system contains another pikelny component, where the number of propylene glycol does not exceed 5%.

11. The composition according to claim 1, where the aqueous phase contains 1-5 wt.% of ethanol.

12. The composition according to claim 1, additionally containing 0.5-3 wt.% water-soluble carbon funds with high refractive index selected from the group consisting of C is a waste of triglyceride-7, glycolate of glycereth-7 and lactate of glycereth-5.

13. The composition according to claim 1, additionally containing 0.5-3 wt.% water-soluble carbon funds with high refractive index selected from the group consisting of additional quantities of glycine (which is not part of the original salt), glycerin, trimethylglycine and alanine.

14. The composition according to claim 1, where the silicone surfactant is a silicone copolyol selected from the group consisting of compounds of formulas I and II, where
(a) formula I has the following form:
(R10)3-SiO-[(R11)2-SiO]x-[Si(R12)(Rb-O-(C2H4O)p-(C3H6O)s-Rc)O]y-Si-(R13)3
the formula I
where R10, R11, R12and R13may be the same or different and each is selected from the group consisting of C1-C6 alkyl; Rbrefers to the radical-CmH2m-; Rcdenotes a terminal radical, which is a hydrogen, alkyl group containing from one to six carbon atoms, acyl group, which present an ester with a terminal alkyl group containing 1-4 carbon atoms, or phenyl group; m has a value from two to eight; p and s have values such that when the mass oxyalkylene fragment -(C2H4O) p-(C3H6O)s- is in the range from 200 to 5000; oxyalkylene fragment contains from fifty to one hundred mole percent oxyethylene elements -(C2H4O)pand one to fifty mole percent oxypropylene elements - (C3H6O)s-; x has a value from 8 to 400; and y has a value from 2 to 40;
(b) formula II has the following form:
(R10)3-SiO-[(R11)2-SiO]x-[Si(R12)(Rb-O-(C2H4O)p-Rc)O]y-Si-(R13)3
formula II
where p has a value from 6 to 16; x has a value from 6 to 100; y has a value from 1 to 20, and the other fragments have the same definition as in formula I; and
(c) alternative embodiments of formulas I and II, where the linking group Rb, oxyalkylene fragments and end the radical Rctake a position associated with the ends of the siloxane chain, and is not associated with the silicon atom in the siloxane chain.

15. The composition according to claim 1, where desiliconizing the solubilizer aromatic means selected from the group consisting of miristinovoi ether PPG-3, the hydrogenated polyisobutene and C12-15 alkylbenzoates.

16. The composition according to claim 1, additionally containing 0-1 wt.% silicone softening means with a refractive index <1,4200 at 21°C, selected from the group consisting of
(i) volatile LINEST is x polydiorganosiloxane with a flash point ≤100°C;
(ii) non-volatile linear polydiorganosiloxane with flash point >100°C; and
(iii) silanols, in which one or two of the alkyl groups of the above compounds (i) or (ii) replaced by a hydroxyl group.

17. The composition according to claim 1, containing 0.5-2 wt.% a solubilizer aromatic funds.

18. The composition according to claim 1, additionally containing an odorant or component, masking the smell.

19. Composition according to any one of claims 1 to 18, which does not contain waxes, cellulose polymers and alginates.

20. The composition according to claim 1, which includes:
(a) 17-23 wt.% oil phase, which contains:
(i) 10-20 wt.% one or more cyclomethicone;
(ii) of 0.6-0.8 wt.% silicone surfactants;
(iii) 0.5 to 2 wt.% a solubilizer aromatic funds; and (b) 77-83 wt.% the aqueous phase, which contains:
(i) 17-25 wt.% in terms of the anhydrous compound of antiperspirant active salt;
(ii) 4-8% wt.% water-soluble pikolinos system, which contains at least 0.2% propylene glycol and other pikelny component selected from the group consisting of dipropyleneglycol, tripropyleneglycol, 2-methyl-1,3-propane diol, 1,3-propane diol, methylpropylamine, low molecular weight polyethylene glycol;
(iv) 0.8 to 3 wt.% an ionisable, water-soluble inorganic or organic salts of monovalent or divalent metals.

21. the song according to claim 1, containing 3-7 wt.% propylene glycol in combination with either 2-methylpropanol or dipropyleneglycol.

22. The composition according to claim 1 or 20, optionally containing 1-4 wt.% ethanol or propanol.

23. The composition according to claim 1, containing 9-20 wt.% cyclomethicone.

24. The composition according to claim 1, containing 0.6 to 0.8 wt.% silicone surfactants.

25. The composition according to claim 1, containing 0.5-2 wt.% a solubilizer aromatic funds.

26. The composition according to claim 1, containing 45-65 wt.% water.

27. Composition according to any one of claims 1 to 18, 20 to 24 or 26, which contains no volatile linear silicones and/or non-volatile silicones.



 

Same patents:

FIELD: medicine.

SUBSTANCE: external skin preparation contains as active components a ferrous compound and a compound chosen from 5-aminolevulin acid, salt of 5-aminolevulin acid, ester of 5-aminolevulin acids, ester of salt of 5-aminolevulin acids, N-acyl-5-aminolevulin acids, salts of N-acyl-5 aminolevulin acid and ester of N-acyl-5-aminolevulin acid. The ferrous compound is chosen from iron (II) citrate, sodium-iron citrate, ammonium-iron citrate, iron acetate, iron oxalate, iron (II) succinate, sodium-iron succinate and citrate, iron (II) pyrophosphate, iron (III) pyrophosphate, heme iron, iron dextrane, iron lactate, iron (II) gluconate, sodium-iron diethylene triaminepentaacetate, ammonium-iron diethylene triaminepentaacetate, ethylenediaminetetraacetate sodium-iron ethylene aminpentaacetate, ammonium-iron ethylene aminpentaacetate, iron triethylene tetraamine, sodium-iron dicarboxymehtyl glutamate and ammonium-iron dicarboxymehtyl glutamate.

EFFECT: improved skin look, prevention or reduction of roughness, dryness, wrinkles, flabbiness, and pigment spots, efficient for atopic dermatitis.

16 cl, 2 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

Protective cream // 2380088

FIELD: medicine.

SUBSTANCE: invention concerns cosmetology and represents a protective cream containing soap, a mineral vehicle, a preserving agent and water, differing that it contains potassium phytogenesis soap, kaolin or talc as said mineral vehicle and in addition, natural saturated and unsaturated higher fatty acids, cetyl or cetearyl alcohol, low-molecular organic acid and a biologically-active additive. The ingredients of the cream are taken in certain proportions.

EFFECT: invention provides reduction of negative effect of the cream on hand skin by reducing its pH to the level close to physiological pH of skin, and given cream can stimulate the regenerative function of skin and protect skin from other harmful non-chemical factors.

7 cl, 33 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a cosmetic composition for lips, containing at least one first polyester which can be produced by reaction of at least one polyol, containing 3 to 12 carbon atoms and 3 to 6 hydroxyl groups, at least one nonaromatic branched monocarboxyl acid chosen from the group, at least one aromatic monocarboxylic acid, chosen from the group and at least one polycarboxyl acid containing at least 2 carboxyl groups COOH, and/or cyclic anhydride of such polycarboxyl acid containing 3 to 18 carbon atoms; and at least one second polyester which can be produced by reaction of at least one polyol, containing 3 to 12 carbon atoms and 3 to 6 hydroxyl groups, at least one nonaromatic linear monocarboxyl acid chosen from the group, at least one aromatic monocarboxyl acid, chosen from the group and at least one polycarboxyl acid containing at least 2 carboxyl groups COOH, and/or cyclic anhydride of such polycarboxyl acid containing 3 to 18 carbon atoms. The first and second polyesters are in the composition in certain mass ratio.

EFFECT: invention provides stability and improved shine of deposited film.

10 cl, 9 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, more specifically to a soft aqueous composition for hair and skin cleaning that contains: i) medium-chain alkylethoxysulfosuccinate, ii) amphoteric surface-active substance, iii) long-chain alkylethoxysulfosuccinate, where long-chain alkylethoxysulfosuccinate component iii) is found in the composition in amount 0.1% to 6% of total medium-chain alkylethoxysulfosuccinate component i).

EFFECT: invention allows producing storage-stable soft cleaning compositions for hair and skin providing moistening and conditioning action.

9 cl, 6 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, more specifically to a soft aqueous composition for hair and skin cleaning that contains: i) medium-chain alkylethoxysulfosuccinate, ii) amphoteric surface-active substance, iii) long-chain alkylethoxysulfosuccinate, where long-chain alkylethoxysulfosuccinate component iii) is found in the composition in amount 0.1% to 6% of total medium-chain alkylethoxysulfosuccinate component i).

EFFECT: invention allows producing storage-stable soft cleaning compositions for hair and skin providing moistening and conditioning action.

9 cl, 6 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention concerns cosmetology and represents a cosmetic composition containing at least one silicone-polyamide copolymer, at least one volatile alcohol and, at least one thickener, where said copolymer contains at least one fragment (III) or (IV).

EFFECT: invention provides production of lubrication free or lubrication resistant compositions, as well as ensures improvement of keratinised tissue and provides improved by-touch characteristics in application and shows water resistance.

35 cl, 4 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention concerns cosmetology and represents a cosmetic composition containing at least one silicone-polyamide copolymer, at least one volatile alcohol and, at least one thickener, where said copolymer contains at least one fragment (III) or (IV).

EFFECT: invention provides production of lubrication free or lubrication resistant compositions, as well as ensures improvement of keratinised tissue and provides improved by-touch characteristics in application and shows water resistance.

35 cl, 4 ex, 2 tbl

FIELD: medicine.

SUBSTANCE: invention concerns cosmetic industry, particularly to an oral care composition. The oral care composition containing propolis extract, a nonionic antibacterial substance representing halogenated diphenyl ester, an active compound for oral care chosen from: a cationic antibacterial substance, an adhesion preventing substance, a substance decomposing biological films or an antiinflammatory substance, and a fluorine ion source.

EFFECT: composition effectively prevents development of oral diseases.

24 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and concerns a surfactant composition containing at least one sorbitan ester and at least one sorbite ester where average of carbon atoms of sorbitan ester hydrofuge exceeds that of sorbite ester.

EFFECT: development of the composition to be applied for stabilisation of emulsions, especially personal hygiene or cosmetic products.

19 cl, 8 ex

FIELD: medicine.

SUBSTANCE: drug preparation for toxicosis relief in early pregnancy exhibiting immune corrective, diuretic action contains yellow bedstraw tincture produced under certain conditions.

EFFECT: drug preparation effectively relieves toxicosis in early pregnancy.

4 cl, 1 tbl

FIELD: technological processes.

SUBSTANCE: ground birch bark is extracted by diethyl ether with separation of betulenol. Then birch bark residue is extracted by water with hydraulic module of 1:15-20 at the temperature of 95-100°C for 1.5-2.0 hours. Produced solution of water soluble substances is concentrated down to 1/3 of initial volume, saturated with sodium chloride, and produced residue is separated by filtration, filtrate is thrice extracted by ethyl acetate and concentrated down to 1/12-1/15 of initial volume, dissolved with chloroform, and proanthocyanidins are extracted.

EFFECT: invention makes it possible to achieve the specified purpose.

1 ex

FIELD: medicine.

SUBSTANCE: external skin preparation contains as active components a ferrous compound and a compound chosen from 5-aminolevulin acid, salt of 5-aminolevulin acid, ester of 5-aminolevulin acids, ester of salt of 5-aminolevulin acids, N-acyl-5-aminolevulin acids, salts of N-acyl-5 aminolevulin acid and ester of N-acyl-5-aminolevulin acid. The ferrous compound is chosen from iron (II) citrate, sodium-iron citrate, ammonium-iron citrate, iron acetate, iron oxalate, iron (II) succinate, sodium-iron succinate and citrate, iron (II) pyrophosphate, iron (III) pyrophosphate, heme iron, iron dextrane, iron lactate, iron (II) gluconate, sodium-iron diethylene triaminepentaacetate, ammonium-iron diethylene triaminepentaacetate, ethylenediaminetetraacetate sodium-iron ethylene aminpentaacetate, ammonium-iron ethylene aminpentaacetate, iron triethylene tetraamine, sodium-iron dicarboxymehtyl glutamate and ammonium-iron dicarboxymehtyl glutamate.

EFFECT: improved skin look, prevention or reduction of roughness, dryness, wrinkles, flabbiness, and pigment spots, efficient for atopic dermatitis.

16 cl, 2 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: paste for oral cleansing contains: silicon dioxide, glycerine, PEG 400, xylite, disodium EDTA, papain, lysozyme, lactulose, sodium carboxymethyl cellulose, Carbomer, ribonuclease, Lydasa, sodium lauroyl sarcosinate, sodium lauroyl sulphate, cocamidopropyl betaine, reduced glutathione, camomile extract, parsley extract, grapeseed extract, glycospheres (liposomes), tetrapotassium pyrophosphate, tetrasodium pyrophosphate, disodium pyrophosphate, sodium saccharinate, citric acid, sodium citrate, spruce extract, sage extract, chondroitin sulphate, betaine, aminofluoride, sodium fluoride, sodium methyl paraben, sodium propyl paraben, the titanium dioxide, an aromatiser, polyvinylpyrrolidone, demineralised water in the certain ratio.

EFFECT: high-effective product prevents development of herpetic stomatitis, moistens oral cavity, restores damaged parodentium tissues, and reduces formation of dental deposit on the tooth surface.

9 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: drug preparation for toxicosis relief in early pregnancy exhibiting immune corrective, diuretic action contains yellow bedstraw tincture produced under certain conditions.

EFFECT: drug preparation effectively relieves toxicosis in early pregnancy.

4 cl, 1 tbl

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