Synergistic fungicidal combinations of biologically active substances and application thereof for undesired plant pathogenic fungi control

FIELD: medicine.

SUBSTANCE: there are described synergistic fungicidal combinations of biologically active substances which contain one carboxamide of general formula (I) , (group 1) where A, R1, R2 and R3 have values presented in the patent claim, and a biologically active substance chosen from compound groups specified in the patent claim (2) - (17) have. There is described application of said agent for undesired plant pathogenic fungi control.

EFFECT: extended range of the agents for undesired plant pathogenic fungi control.

8 cl, 13 tbl, 12 ex

 

This invention relates to the field of combating fungi, and more particularly to a new synergistic fungicidal combinations of biologically active substances, which consist, on the one hand, from the known carboxamido and, on the other hand, other known fungicidal biologically active substances, and to their use for controlling undesirable plant pathogenic fungi.

It is known that certain carboxamide possess fungicidal properties. For example, the known N-(3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-yl)-3-(deformity)-1-methyl-1H-pyrazole-4-carboxamide from DE-A 10215292, 3-(trifluoromethyl)-N-{3'-fluoro-4'-[(E)-(methoxyimino)methyl]-1,1'-biphenyl-2-yl}-1-methyl-1H-pyrazole-4-carboxamid from WO 02/08197, and N-(3',4'-dichloro-1,1'-biphenyl-2-yl)-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide from WO 00/14701. The effectiveness of these substances is good, but at small expenditure amounts in some cases insufficient. Further, it is known that numerous triazolone derivatives, aniline derivatives, dicarboximide and other heterocycles can be used for combating fungi (see EP-A 0040345, DE-A 2201063, DE-A 2324010, Pesticide Manual, 9th edition (1991), p. 249 and 827, EP-A 0382375 and EP-A 0515901). The effectiveness of these compounds at low expenditure amounts are not always sufficient. Further, it is known that 1-(3,5-dimethyl-isoxazol-4-sulfonyl)-2-chloro-6,6-debtor-[1,3]-dioxolo-[4,5f]-benzimida the ol has fungicidal properties (see WO 97/06171). Finally, it is known that substituted kalaidjieva possess fungicidal properties (see DE-A1-19646407, ER-IN-712396).

The objective of the invention is to expand the range of high-level tools to combat unwanted phytopathogenic fungi.

The problem is solved, we offer a synergistic fungicidal combinations of biologically active substances that contain carboxamid General formula (I) (group - 1)

where

R1means hydrogen or fluorine,

R2means halogen,

R3means hydrogen or halogen,

And means one of the following radicals A1-A2:

R4means (C1-C3)-alkyl,

R5means (C1-C3-haloalkyl 2 fluorine atoms,

R6means hydrogen,

R7means (C1-C3)-alkyl,

R8means (C1-C3-haloalkyl 2 fluorine atoms,

and the biologically active substance selected from the following groups of compounds:

group (2) strobilurins General formula (II)

where

And1means one of the groups

And2mean NH or O,

And3N or SN,

L denotes one of the groups

moreover, the chemical bond is indicated by an asterisk (*)attached to the phenyl ring,

R9means phenyl, phenoxy group or pyridinyl, which is not substituted or substituted once or twice, identically or differently chlorine, cyano-group, stands or trifluoromethyl, or denotes 1-(4-chlorophenyl)-pyrazole-3-yl,

R10means hydrogen or fluorine;

group (3) triazoles of General formula (III)

where

Q denotes hydrogen or SH,

m denotes 0 or 1,

R11means hydrogen, fluorine, chlorine or phenyl,

R12means hydrogen or chlorine,

And4means of a simple chemical bond, -CH2-, -(CH2)2- or-O-,

And5means,

R13means hydrogen or a hydroxy group,

R14mean 1-chlorocyclopropane, (C1-C4)-alkyl or (C1-C6-hydroxyalkyl,

R13and R14in addition, together denote-O-CH2-CH(R15)-O - or-O-CH(2-chlorophenyl)-,

R15means (C1-C4)-alkyl;

group (4) sulfenamide formula (IV)

where R16means methyl;

group (5) valinamide, the choice is emich from

(5-1) iprovalicarb,

(5-3) benthiavalicarb;

group (6) carboxamido General formula (V)

where

X is 2-chloro-3-pyridinyl, 1-methylpyrazole-4-yl, which is substituted in 3-position by trifluoromethyl, 1-methylcyclohexyl or 3,4-dichloroisothiazol-5-yl,

Y means of a simple chemical bond, or theoffender,

Z stands for a group

or (C1-C6)-alkyl,

And6means SN,

R17means hydrogen, chlorine, phenyl, substituted once by chlorine, or cyano,

R18means hydrogen or chlorine,

R19means hydrogen or a hydroxy group,

group (7) dithiocarbamato. choose from a range, including

(7-1) MANCOZEB,

(7-2) propineb,

(7-3) zineb,

group (8) acylalanines the General formula (VI)

where

* means a carbon atom in R - or S-configuration, preferably in the S-configuration,

R20means benzyl or methoxymethyl;

group (9) of aniline-pyrimidines of General formula (VII)

where

R21means methyl or cyclopropyl;

group (10) benzimidazole of the formula (VIII)

where

R22and R23each signify hydrogen,

R24means hydrogen,

R25means methoxycarbonylamino-group;

the group (11) carbamates of General formula (IX)

where

R26means n - or ISO-propyl,

R27means di((C1-C2)-alkyl)amino-(C2-C4)-alkyl,

including salts of these compounds;

group (12) of dicarboximide representing iprodion;

group (13) imidazole, representing triazoxide;

group (14) phosphonate, representing fosetyl-Al:

group (15) fungicides selected from compounds

(15-1) CHLOROTHALONIL,

(15-2) spiroxamine,

(15-3) fenamidone,

group (16) the derivative of urea, representing pencycuron;

group (17) triazolopyrimidines representing

(17-1) 5-chloro-N-[(1S)-2,2,2-Cryptor-1-methylethyl]-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine,

(17-2) 5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-tryptophanyl)[1,2,4]triazolo[1,5-a]pyrimidine-7-amine.

Preferred carboxamide formula (I), where

R1means hydrogen or fluorine,

R2means chlorine or bromine,

R3means hydrogen or chlorine,

And means A1 or A2:

R4means methyl,

R5means deformity,

R6means hydrogen,

R7means methyl,

R8means deformity.

Formula (I) embraces the following preferred compounds of group (1):

(1-1) N-(3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-yl)-3-(deformity)-1-methyl-1H-pee the azole-4-carboxamide (known from WO 03/070705),

(1-2) N-(4'-chloro-3'-fluoro-1,1'-biphenyl-2-yl)-2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide (known from WO 03/066609),

(1-3) N-(4'-chloro-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (known from WO 03/066610),

(1-4) N-(4'-bromo-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (known from WO 03/066610),

(1-5) N-(4'-chloro-3'-fluoro-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (known from WO 03/066610).

Preferred combinations of biologically active substances according to the invention, which, together with (1-1) N-(3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-yl)-3-(deformity)-1-methyl-1H-pyrazole-4-carboxamide (group 1), contain biologically active substance which is selected from groups(2)-(17).

Preferred combinations of biologically active substances, which, together with (1-4) - N-(4'-bromo-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (group 1), contain biologically active substance which is selected from groups (2) and (3).

Formula (II) embraces the following preferred biologically active substances of group (2):

(2-1) AZOXYSTROBIN (known from EP-A 0382375) formula

(2-2) fluoxastrobin (known from DE-A 19602095) formula

(2-3) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoro-4-pyrimidinyl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamine (swesty from DE-A 19646407, EP-0712396) formula

(2-4) Trifloxystrobin (known from EP-A 0460575) formula

(2-5) kresoxim-methyl (known from EP-A 0253213) formula

(2-6) picoxystrobin (known from EP-A 0278595) formula

(2-7) pyraclostrobin (known from DE-A 4423612) formula

Formula (III) includes the following preferred biologically active substances of group (3):

(3-1) itaconate (known from DE-A 2551560) formula

(3-2) propiconazole (known from DE-A 2551560) formula

(3-3) hexaconazole (known from DE-A 3042303) formula

(3-4) epoxiconazol (known from EP-A 0196038) formula

(3-5) prothioconazole (known from WO 96/16048) formula

(3-6) tebuconazole (known from EP-A 0040345) formula

(3-7) bitertanol (known from DE-A 2324010) formula

(3-8) triadimenol (known from DE-A 2324010) formula

Sulfenamid formula (IV) are known from DE-A 1193498. His name: tolylfluanid.

Iprovalicarb group 5 (5-1) known from DE-A 4026966. It has the formula

Benthiavalicarb group 5 (5-2) is known from WO 96/04252. It has the formula

Formula (V) includes the following preferred biologically active substances of group (6):

(6-1) boscalid (known from DE-A 19531813) formula

(6-2) (3-p-tolyl-thiophene-2-yl)amide 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (known from EP-A 0737682) formula

(6-3) fenhexamid (known from EP-A 0339418) formula

(6-4) 3,4-dichloro-N-(2-cyanophenyl)isothiazol-5-carboxamide (known from WO 99/24413) formula

(6-5) pentopia (known from EP-A 0737682) formula

(6-6) N-[2-(1,3-dimethylbutyl)phenyl]-1-methyl-4-(trifluoromethyl)-1H-pyrrol-3-carboxamide (known from WO 02/38542) formula

MANCOZEB group 7 (7-1) known from DE-A 1234704. His name according to IUPAC: manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt,

Propineb group 7 (7-2) is known from GB 935981, has the formula

and zineb group 7 (7-3) known from DE-A 1081446, has the formula

Formula (VI) covers the following biologically active substances from the group of (8):

(8-1) benalaxyl (known from DE-A 2903612) formula

(8-2) metalaxyl (known from DE-A 2515091) formula

(8-3) metalaxyl-M (known from WO 96/01559) formula

(8-4) benalaxyl-M formula

Formula (VII) covers the following biologically active substances of group (9):

(9-1) cyprodinil (known from EP-A 0310550) formula

(9-2) Pyrimethanil (known from DD 151404) formula

Formula (VIII) comprises the following biologically active substance from group (10): carbendazim (known from US 3010968) formula

Formula (IX) covers the following biologically active substances of group (11): (11-1) propamocarb (known from US 3513241) formula

(11-2) propamocarb hydrochloride (known from US 3513241) formula

(11-3) propamocarb-fosetyl formula

Iprodion group (12) is known from DE-A 2149923). It has the formula

Triazoxide group (13) is known from DE-A 2802488 and has the formula

Fosetyl-Al group (14) known from DE-A 2456627 and has the formula

CHLOROTHALONIL (15-1) is known from US 3290353. It has the formula

/p>

Spiroxamine (15-2) is known from DE-A 3735555. It has the formula

Fenamidone (15-3) is known from EP-A 0629616. It has the formula

Pencycuron (group 16) is known from DE-A 2732257. It has the formula

5-chloro-N-[(1S)-2,2,2-Cryptor-1-methylethyl]-6-(2,4,6-tryptophanyl)[1,2,4]triazolo[1,5-a]-pyrimidine-7-amine (17-1) formula

known from US 5986135, and

5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]-pyrimidine-7-amine (17-2) formula

known from WO 02/38565.

The combination of biologically active substances according to the invention contain, along with one biologically active substance of the formula (I)at least one biologically active substance of the compounds included in group (2)-(17). Moreover, they can contain other fungicide existing primitively components.

If the biologically active substance combinations of biologically active substances according to the invention are present in certain weight ratios, the synergistic effect can be seen most clearly. However, the weight ratio of biologically active compounds in the combinations of biologically active substances can vary in a relatively wide area. In General, the combination soglasovannom invention contain biologically active substance of the formula (I) and biologically active substances from one of the groups (2)-(17) in the ratios which in the example shown in table 1.

Ratio when mixing are based on weight ratios. It should be understood as the ratio of the biologically active substance of the formula (I): primitively component.

Table 1
The weight ratio when mixing
Primitively componentThe preferred weight ratioParticularly preferred weight ratio
Group (2): strobilurin50:1 to 1:5010:1 to 1:20
Group (3): triazole without (3-5)50:1 to 1:5020:1 to 1:20
(3-5): prothioconazole50:1 to 1:5010:1 to 1:20
Group (4): sulfenamid1:1 to 1:1501:1 to 1:100
Group (5): valinamide50:1 to 1:5010:1 to 1:20
Group (6): carboxamide 50:1 to 1:5020:1 to 1:20
Group (7): dithiocarbamate1:1 to 1:1501:1 to 1:100
Group (8): acylalanines10:1 to 1:1505:1 to 1:100
Group (9): aniline-pyrimidines5:1 to 1:501:1 to 1:20
Group (10): benzimidazole10:1 to 1:505:1 to 1:20
Group (11): carbamates1:1 to 1:1501:1 to 1:100
Group (12): iprodion5:1 to 1:501:1 to 1:20
Group (13): imidazole50:1 to 1:5010:1 to 1:20
Group (14): phosphonate10:1 to 1:1501:1 to 1:100
(15-1): CHLOROTHALONIL1:1 to 1:1501:1 to 1:100

Table 1: continuation
The weight ratio when mixing
Primitively componentThe preferred weight ratioParticularly preferred weight ratio
(15-2): spiroxamine50:1 to 1:5010:1 to 1:20
(15-3): fenamidone50:1 to 1:5010:1 to 1:20
Group (16): pencycuron50:1 to 1:5010:1 to 1:20
Group (17): triazolopyrimidine50:1 to 1:5010:1 to 1:20

The weight ratio when mixing in each case should be selected such that it's a mixture with synergistic effect. The weight ratio when mixing one of the compounds of formula (I) to one compound taken from the group (2)-(17), can vary between different compounds of the same group.

The combination of biologically active substances according to the invention have very good fungicidal properties and can be used for combating phytopathogenic fungi, such as Plasmodiophoromycetes, Oomycetes, Chytridiomycota, Zygomycetes, Ascomycetes, Basidiomycetes, Deuteromycetes is so

The combination of biologically active substances according to the invention are particularly well suited for combating Erysiphe graminis, Pyrenophora teres and Leptosphaeria nodorum.

As an example, but in any case not limiting, you can call some pathogens of fungal diseases which come under the above broader concepts:

Pythium species such as, for example, Pythium ultimum; Phytophthora species, such as, for example, Phytophthora infestans; Pseudoperonospora species, such as, for example, Pseudoperonospora humuli or Pseudoperonospora cubensis; Plasmopara species, such as, for example, Plasmopara viticola; Bremia species, such as, for example, Bremia lactucae; Peronospora.-species, such as, for example, Peronospora. pisi or P.brassicae; Erysiphe species, such as, for example, Erysiphe graminis; Sphaerotheca species, such as, for example, Sphaerotheca fuliginea; Podosphaera species, such as, for example, Podosphaera leucotricha; Venturia species, such as, for example, Venturia inaequalis; Pyrenophora species, such as, for example, Pyrenophora teres or P.graminea (conidia form: Cereals, SYN: Helminthosporium); Cochliobolus species, such as, for example, Cochliobolus sativus (conidia form: Cereals, SYN: Helminthosporium); Uromyces species, such as, for example, Uromyces appendiculatus; Puccinia species, such as, for example, Puccinia recondita; Sclerotinia species, such as, for example, Sclerotinia sclerotiorum; Tilletia species, such as, for example, Tilletia caries; Ustilago species, such as, for example, Ustilago nuda or Ustilago avenae; Pellicularia species, such as, for example, Pellicularia sasakii; Pyricularia species, such as, for example, Pyricularia oryzae; Fusarium-the IDA, such as, for example, Fusarium culmorum; Botrytis species, such as, for example, Botrytis cinerea; Septoria species, such as, for example, Septoria nodorum; Leptosphaeria species, such as, for example, Leptosphaeria nodorum; Cercospora species, such as, for example, Cercospora canescens; Alternaria species, such as, for example, Alternaria brassicae; Pseudocercosporella species, such as, for example, Pseudocercosporella herpotrichoides, Rhizoctonia species such as, for example, Rhizoctonia solani.

Good tolerance of plants combinations of biologically active substances in concentrations required for combating plant diseases, allows the processing of all parts of plants (aboveground parts of plants and roots), seeds and seedlings, and soil. The combination of biologically active substances according to the invention can be used for drawing on the sheets, and also for seed.

The combination of biologically active substances according to the invention is also suitable for increasing the size of the harvest. In addition, they have minimal toxicity and are well tolerated by plants.

According to this invention can be processed to whole plants or parts of plants. Under the plants understand all plants and plant populations such as desired and undesired wild or cultivated plants (including naturally occurring crop plants). Cultivated plants can be plants which tion, who received traditional methods of cultivation and optimization or biotechnology or genetic engineering, or a combination of these methods, including the transgenic plants and including the plant varieties protected or not protected legally right for the protection of varieties. Under parts of plants should understand aboveground and below-ground parts and organs of plants, such as shoot (shoot), leaf, flower and root, and includes, for example, leaves, needles, stems, flowers, fruits and seeds and also roots, tubers and rhizomes. The plant parts also include marketable product yield and vegetative and generative breeding material, for example cuttings, tubers, rhizomes, cuttings and seeds.

Processing according to this invention of plants or parts of plants of biologically active substances takes place directly or by action on their environment, habitat or storage premises customary treatment methods, for example by dipping, spraying, steam treatment, the formation of fog, dispersion, and deposition, and in the case of breeding material, in particular seeds, by forming them single-layer and multi-layer shells.

As mentioned above, according to the invention it is possible to treat all plants and plant parts. In one preferred variation izopet the process of plant species and plant varieties, and parts thereof, which are found in the wild or obtained from a conventional biological breeding methods, such as crossing or fusion of protoplasts. In another preferred embodiment of the invention is treated transgenic plants and plant varieties which are obtained by the methods of genetic engineering, if necessary in combination with commonly used methods (genetically modified organisms), and parts thereof. The term "plants", respectively, "parts of plants" explained above.

More preferably treated according to this invention is commercially available or commonly used varieties of plants.

Depending on plant species, respectively, varieties of plants, their location and growth conditions (soils, climate, vegetation period, diet), with the process according to the invention may also be observed suradditions ("synergistic") effects. So, for example, can reduce the expenditure of the amounts and/or expansion of the spectrum, and/or increasing the effectiveness of substances and agents used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or salt content in the water or soil, increase productivity flowering and easier harvesting, accelerated maturation, increase the size of the harvest, improved quality and/or higher nutritional value of the product yield, high stability during storage and/or machinability harvest products that actually exceed the expected effects.

It is preferable to be processed according to this invention transgenic (obtained using genetic engineering technology) plants, respectively, the varieties of plants are all plants obtained by genetic engineering modifications of the genetic material that gave these plants is particularly advantageous useful properties ("Traits"). Examples of such properties are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or salt content in water and soil, increased productivity flowering and easier harvesting, accelerated maturation, the increase in yield, improved quality and/or higher nutritional value of the product yield, high stability during storage and/or machinability harvest products. Other and especially prominent examples of such properties are the increased defense of the plants against animal and microbial pests, such as insects, mites, phytopathogenic fungi, bacteria and/or viruses, and also increased tolerance of the plants in relation to certain herbicide biologically act the main substances. As an example, transgenic plants mentioned are the important crop plants, such as cereals (wheat, rice), maize, soybeans, potatoes, cotton, rape and also fruit plants (with such fruits as apples, pears, citrus fruits and grapes), with corn, soybeans, potatoes, cotton and oilseed rape is more preferable. As properties ("Traits") particularly emphasizes increased protection of plants from insects with the help of toxins formed in the plants, especially those that are produced in plants by the genetic material from Bacillus Thuringiensis (for example, through the genes CryIA(a), CryIA(b)CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c Cry2Ab, Cry3Bb and CryIF and also combinations thereof (hereinafter "Bt plants"). As properties ("Traits") especially stresses also increased tolerance of the plants in relation to certain herbicide biologically active substances, for example, imidazolinones, sulfonylureas, glyphosate or phosphinotricin (for example the "PAT"gene). Genes that give the corresponding desired properties ("Traits") in transgenic plants can occur in combination with each other. As examples of "Bt plants" should be called varieties of corn, cotton, soybeans and potatoes, which are sold under the trade names YIELD GARD® (for example maize, cotton, soybeans), KnockOut® (for example maize), StarLink® (for example, ukurasa), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf® (potato). As an example, are tolerant to the herbicides plant should be called varieties of corn, cotton and soybeans, which are sold under the trade names Roundup Ready® (tolerance to glyphosate, for example maize, cotton, soya bean), Liberty Link® (tolerance to phosphinotricin, for example, rape), IMI® (tolerance to imidazolinones) and STS® (tolerance to sulfonylureas, for example, corn). As herbicide-resistant plants (usually grown on tolerance to herbicides) should also mention varieties which are sold under the name Clearfield® (for example maize). Needless to say, these statements are valid for varieties that will be developed in the future, respectively, will appear in the future on the market of plant varieties with these or new ones developed in the future as properties ("Traits").

The combination of biologically active substances according to the invention, depending on their physical and/or chemical properties can be converted to conventional preparations such as solutions, emulsions, suspensions, powders, means to spray, foams, pastes, soluble powders, granules, aerosols, suspension-emulsion concentrates, impregnated with biologically active substances of natural and synthetic substances, as well as in polymer microcapsules ve is the EU ETS and coating materials for seed, and drugs in ultra-small volumes for the formation of cold and warm mist.

These drugs get in a known manner, for example, mixing of biologically active substances, respectively, combinations of biologically active substances with extenders, that is liquid solvents, liquefied gases under pressure and/or solid carriers, optionally with the use of surface-active agents, that is emulsifying means and/or dispersing funds, and/or foaming agents.

In the case of using water as a filler may also be used organic solvents as auxiliary to dissolve substances. As liquid solvents are meant essentially the following: aromatics, such as xylene, toluene or alkylnaphthalenes, chlorinated aromatic or chlorinated aliphatic hydrocarbons, such as chlorobenzene, chlorethylene and methylene chloride, saturated hydrocarbons such as cyclohexane or paraffins, for example, fractions of oils and mineral and vegetable oils, alcohols, such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents, such as dimethylformamide and dimethyls epoxid, as well as water.

Under liquefied gaseous extenders or carriers understand such liquids at normal temperature and normal pressure are gaseous, for example, carrier gases, aerosols, such as butane, propane, nitrogen and carbon dioxide.

As solid carriers are: for example ammonium salts and grinding of natural rocks, such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and the grinding of synthetic stones, such as highly dispersed silicic acid, alumina and silicates. As solid carriers for granules are meant, for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiola, dolomite, and also synthetic granules of grinding of inorganic and organic substances, and also granules of organic material such as sawdust, shell kolkovich nuts, corn cobs and stalks of tobacco. As emulsifiers and foaming means are suitable: for example nonionic and anionic emulsifiers, such as esters of polyoxyethylene fatty acid esters of polyoxyethylene fatty alcohol, for example, alkylarylsulphonates ether, alkyl sulphonates, alkyl sulphates, arylsulfonate, and hydrolysates of egg protein. In the when asked dispersing means mean: for example, lignin-sulfite liquors and methylcellulose.

The drugs can be used adhesive means, such as carboxymethylcellulose, natural and synthetic powdered, granular or latex form polymers, such as gum Arabic, polyvinyl alcohol, polyvinyl acetate, and also natural phospholipids, such as Catalina and lecithins, and synthetic phospholipids. Other additives can be natural or vegetable oil.

Can be used colorants such as inorganic pigments, for example iron oxide, titanium oxide, ferrocen blue, and organic dyestuffs, such as alizarin, azo and metallophthalocyanine dyes, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The content of biologically active substance in ready-to-use forms, prepared from commercially available preparations can vary within wide limits. The concentration of biologically active substances in ready to use forms for combating animal pests, such as insects and acarida can be from 0.0000001 to 95 weight. percent of biologically active substances, preferably from 0.0001 to 1 weight. percent. The application is usually carried out by a method suited to the type of drug, ready for use./p>

Drugs to combat unwanted phytopathogenic fungi contain, as a rule, from 0.1 to 95 weight. percent of biologically active substances, preferably from 0.5 to 90 weight. percent.

The combination of biologically active substances according to the invention can be used as themselves, in the form of their preparations and prepared from them are ready to use forms, such as ready-to-use solutions, emulsifiable concentrates, emulsions, suspensions, powders for spraying, soluble powders, spray and granules. Application carried out in the usual way, for example, by pouring (wetting), drip irrigation, spraying, spraying, splashing, spraying, coating, foaming, coating, smearing, dry etching, wet etching, wet etching, the etching in the sludge, scum formation, etc.

The combination of biologically active substances according to the invention can be in the form of drugs, commercially available, and are ready to use forms, prepared from these drugs in combination with other biologically active substances such as insecticides, attractants, sterilant, bactericides, acaricides, nematicides, fungicides, substances that regulate the growth of plants, or herbicides.

When you use the attachment combinations of biologically active substances according to the invention supplies the number depending on the method of application can vary widely. When processing parts of plants expenditure number of combinations of biologically active substances are, as a rule, from 0.1 to 10,000 g/ha, preferably from 10 to 1000 g/ha In the processing of seed material expenditure number of combinations of biologically active substances are generally from 0.001 to 50 g per kilogram of seed, preferably from 0.01 to 10 g per kilogram of seed. Soil supplies the number of combinations of biologically active substances are, as a rule, from 0.1 to 10,000 g/ha, preferably from 1 to 5000 g/ha

The combination of biologically active substances can be used as themselves, in the form of concentrates, or conventional preparations such as powders, granulates, solutions, suspensions, emulsions or pastes.

These kinds of drugs can be obtained by known methods, for example by mixing the biologically active substances with at least one solvent, respectively, diluent, emulsifier, dispersant and/or binder agent or fixing agent, water repellent, if necessary, a drying agent or stabilizer in ultra-small volumes and, if necessary, with dyes and pigments, as well as other auxiliary processing agents.

The good fungicidal activity of combinations of biologically the active substances according to the invention seen from the examples, below. While individual biologically active substances detect weak fungicidal activity, the combinations are active, which exceeds the simple summation of the activities.

A synergistic effect is present in fungicides is always the case, if the fungicidal activity of the combination of biologically active substances more than the sum of the efficiencies of individual biologically active substances.

Expected fungicidal activity for a given combination of two biologically active substances according to Colby (S.R.Colby "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds, 1967, 15, 20-22) is calculated as follows:

if

X is the efficacy when applying the biologically active substance And a consumable amount of m g/ha,

Y means the efficiency in the use of biologically active substances In a consumable amount of n g/ha and

E. means efficiency in the use of biologically active substances a and b with a consumable quantities m and n g/ha,

.

The effectiveness is determined in percentage. Efficiency of 0% corresponds to the control efficiency, while the efficiency of 100% means that does not damage plants.

If the actual fungicidal activity was higher than estimated, the combination of vergadain is in its action, i.e. there is a synergistic effect. In this case, the actually observed efficiency should be higher than the expected value of efficiency (E), calculated by the formula given above. The invention is illustrated by the following examples which are combinations containing carboxamide (1-1) or (1-4) formula

and a biologically active substance selected from the group(2)-(17).

Example

Test on Pyrenophora teres (barley)/curative

Solvent:50 weight. parts N,N-dimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain the appropriate ready-to-use preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for curative activity, young plants inoculant suspension of conidia of Pyrenophora teres. Plants left in an incubation cabin for 48 hours at a temperature of 20°C and a relative humidity of 100%. In conclusion the group of plants are sprayed with a given expenditure amount of biologically active substances.

Plants are placed in a greenhouse at a temperature of about 20°C and a relative humidity of about 80%.

After 12 days after inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table a:
Test on Pyrenophora teres (barley)/curative
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)2543
(2-2) Fluoxastrobin250
(3-6) Tebuconazole2529
(1-1)+(2-2) Fluoxastrobin (1:1)25+257143
(1-1)+(3-6) Tebuconazole (1:1)25+257160
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

The example In

Test on Erysiphe (barley)/protective

Solvent:50 weight. parts N,N-dimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants are sprayed with the specified expenditure to what iCustom the preparation of biologically active substances. After drying of the residue from spraying plants inoculant disputes Erysiphe graminis f.sp.hordei.

Plants are placed in a greenhouse at a temperature of about 20°C and a relative humidity of about 80%, in order to create favorable conditions for the development of powdery mildew pustules.

Later, 6 days after inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table:
Test on Erysiphe (barley)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)12,50
(2-4) Trifloxystrobin12,578
(3-5) Prothioconazole12,567
(1-1)+(2-4) Trifloxystrobin (1:1)12,5+12,59478
(1-1)+(3-5) Prothioconazole (1:1)12,5+12,58967
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

The example

Test on Puccinia (wheat)/curative

Solvent:50 weight. parts N,N-dimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the number the AMI of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants inoculant suspension of conidia of Puccinia recondita. Plants left for 48 hours in an incubation cabin at about 20°C and a relative humidity of 100%.

In conclusion, the plant is treated with the specified feed amount of the preparation of biologically active substances.

Plants are placed in a greenhouse at a temperature of about 20°C and a relative humidity of about 80%, in order to create favorable conditions for the development of rust pustules.

After 8 days after inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table:
Test on Puccinia (wheat)/curative
Biologically active substancesExpenditure number of biologically active compounds in g/ha Efficiency in percent
OBN.*Races.**
(1-1)62,522
(15-2) Spiroxamine62,50
(6-5) Pentopia62,544
(6-4) Carboxamid above formula62,50
(2-6) Picoxystrobin62,578
(1-1)+(15-2) Spiroxamine (1:1)62,5+62,510022
(1-1)+(6-5) Pentopia (1:1)62,5+62,56757
(1-1)+(6-4) Carboxamide (1:1)62,5+62,54422

Table:
Test on Puccinia (wheat)/curative
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
(1-1)+(2-6) Picoxystrobin (1:1)62,5+62,58983
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example D

Test Gibberella zeae (barley)/curative

Solvent:50 weight. parts N,N-dimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

For testing shortly after the activity, young plants inoculant suspension of conidia of Gibberella zeae. Plants left for 24 hours in an incubation cabin at a temperature of 22°C and a relative humidity of 100%. In conclusion, the plants are sprayed with ready-to-use preparation of biologically active substances specified consumable quantities. After drying of the residue from spraying, the plants are placed in a greenhouse under incubation hoods, pervious to light, at a temperature of about 22°C and a relative humidity of about 100%.

Later, 6 days after inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table D:
Test Gibberella zeae (barley)/curative
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN. *Races.**
(1-1)62,540
(2-7) Pyraclostrobin62,580
(3-4) Epoxiconazol62,50
(1-1)+(2-7) Pyraclostrobin (1:1)62,5+62,59088
(1-1)+(3-4) Epoxiconazol (1:1)62,5+62,56040
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example F

Test on Sphaerotheca fuliginea (cucumbers)/protective

Solvent:24.5 weight. parts of acetone,
24.5 weight. partsdimethylacetamide.
Emulsifier:1 weight. part alquilar polyglycolic ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants are sprayed with the specified feed amount of the preparation of biologically active substances. After drying of the residue from spraying plants inoculant aqueous spore suspension Sphaerotheca fuliginea.

Plants are placed in a greenhouse at a temperature of about 23°C and a relative humidity of about 70%.

After 7 days of inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table E:
Test on Sphaerotheca fuliginea (cucumbers)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)430
236
116
0,50
(1-4)20
10
0,50
(2-1) AZOXYSTROBIN0,520
(2-2) Fluoxastrobin10

Table E:
Test on Sphaerotheca fuliginea (cucumbers)/protective
(2-4) Trifloxystrobin210
(2-7) Pyraclostrobin20
(3-5) Prothioconazole143
(3-6) Tebuconazole110
(3-7) Bitertanol10
(4-1) tolylfluanid200
(6-3) Fenhexamid200
(6-5) Pentopia40
(7-1) MANCOZEB20
(7-2) Propineb2011
(9-2) Pyrimethanil200
(12) Iprodion200
(15-1) CHLOROTHALONIL200
(15-2) Spiroxamine200
(17-1) Triazolopyrimidine above formula211
(17-2) Triazolopyrimidine above formula122

Table E:
Test on Sphaerotheca fuliginea (cucumbers)/protective
Biologically active substancesThe expenditure to which icesta of biologically active compounds in g/ha Efficiency in percent
(1-1)+(2-1) AZOXYSTROBIN (1:1)0,5+0,58720
(1-4)+(2-1) AZOXYSTROBIN (1:1)0,5+0,56320
(1-1)+(2-2) Fluoxastrobin (1:1)1+19516
(1-4)+(2-2) Fluoxastrobin (1:1)1+1920
(1-1)+(2-4) Trifloxystrobin (1:1)2+25742
(1-4)+(2-4) Trifloxystrobin (1:1)2+29310
(1-1)+(2-7) Pyraclostrobin (1:1)2+25336
(1-1)+(3-5) Prothioconazole (1:1)1+17052
(1-1)+(3-6) Tebuconazole (1:1)11 9024
(1-1)+(3-7) Bitertanol (1:1)1+15016
(1-1)+(4-1) tolylfluanid (1:10)2+209836
(1-1)+(6-3) Fenhexamid (1:10)2+208536
(1-1)+(6-5) Pentopia (1:1)4+48230
(1-1)+(7-1) MANCOZEB (1:10)2+209336
(1-1)+(7-2) Propineb (1:10)2+206543
(1-1)+(9-2) Pyrimethanil (1:10)2+209636
(1-1)+(12) Iprodion (1:10)2+207436
(1-1)+(15-1) CHLOROTHALONIL (1:10)2+2091 36

Table E:
Test on Sphaerotheca fuliginea (cucumbers)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)+(15-2) Spiroxamine (1:10)2+2010036
(1-1)+(17-1) (1:1)2+26743
(1-1)+(17-2) (1:1)1+19434
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example F

Test on Alternaria solani (tomatoes)/protective

Solvent:24.5 weight. parts of acetone,
24.5 weight. partsdimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants are sprayed with the specified feed amount of the preparation of biologically active substances. After drying of the residue from spraying plants inoculant with an aqueous suspension of spores Alternaria solani.

Plants are placed after this incubation cabin at about 20°C and a relative humidity of about 100%.

Later, 3 days after inoculation are evaluated. 0% means an efficacy which corresponds to the effectiveness of the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, that is, sinergicheskoe.

Table F:
Test on Alternaria solani (tomatoes)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)161
0,542
(1-4)163
0,528
(2-3)0,522
(3-2) Propiconazol0,53
(5-2) Benthiavalicarb1 5
(8-3) Metalaxyl-M0,57
(8-4) Benalaxyl-M0,514
(1-4)+(2-3) (1:1)0,5+0,56744
(1-4)+(3-2) Propiconazole (1:1)0,5+0,55630
(1-1)+(5-2) Benthiavalicarb (1:1)1+17763

Table F:
Test on Alternaria solani (tomatoes)/protective
(1-1)+(8-3) Metalaxyl-M (1:1)0,5+0,56246
(1-1)+(8-4) Benalaxyl-M (1:1)0,5+0,56750
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example G

Test on Phytophthora infestans (tomato)/protective

Solvent:24.5 weight. parts of acetone,
24.5 weight. partsdimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants are sprayed with the specified feed amount of the preparation of biologically active substances. After drying of the residue from spraying plants inoculant water Aspasia spores of Phytophthora infestans. Plants are placed after this incubation cabin at about 20°C and a relative humidity of about 100%. Later, 3 days after inoculation are evaluated. 0% means an efficacy which corresponds effective the STI control, while the efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table G:
Test on Phytophthora infestans (tomato)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)100
50
10
0,50
(4-1) tolylfluanid100
(5-1) Iprovalicarb1064
561
(5-2) Benthiavalicarb0,556
(15-3) Fenamidone0,541
(1-1)+(4-1) tolylfluanid (1:10)1+10510
(1-1)+(5-1) Iprovalicarb (1:1)10+108864
5+57761
(1-1)+(5-2) Benthiavalicarb (1:1)0,5+0,57356
(1-1)+(15-3) Fenamidone (1:1)0,5+0,55141
OBN.*= detected effectiveness.
**= efficiency calculated by the Colby formula.

Example N

Test on Botrytis cinerea (beans)/protective

Solvent:24.5 weight. parts of acetone,
24,5 viscachadimethylacetamide.
Emulsifier:1 weight. part alkylarylsulphonates ether.

To obtain a suitable ready-made preparation of biologically active substances mix 1 weight. part of the biologically active substance or combination of biologically active substances with the above amounts of solvent and emulsifier and dilute the concentrate with water to the desired concentration.

To test for protective activity, young plants are sprayed with the specified feed amount of the preparation of biologically active substances. After drying residue after spraying on each piece put two small pieces of agar, which has acquired Botrytis cinerea. Inoculated plants are placed in a darkened chamber at a temperature of about 20°C and a relative humidity of about 100%.

Later, 2 days after inoculation there is an estimation of the size of the spots lesions on the leaves. 0% means an efficacy which according to the reecting the effectiveness of the control, while the efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table N:
Test on Botrytis cinerea (beans)/protective
Biologically active substancesExpenditure number of biologically active compounds in g/haEfficiency in percent
OBN.*Races.**
(1-1)554
(9-2) Pyrimethanil54
(12) Iprodion513
(1-1)+(9-2) Pyrimethanil (1:1)5+592 56
(1-1)+(12) Iprodion (1:1)5+510060
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example I

Test on Alternaria mali (in vitro)/microtiter plates

Microtest is carried out with the plates for micrometrology with potato-dextrose nutrient medium as a liquid environment for testing. The use of biologically active substances is carried out in the form of technical A.I. (active ingredient)dissolved in acetone.

For inoculation using a suspension of spores Alternaria mali. After 5 days of incubation in the dark with constant shaking (10 Hz) on a spectrophotometer to determine the light transmission of each filled cavitation cavity plates for micrometrology.

0% means an efficacy which corresponds to growth of fungi in the case of the control, whereas an efficacy of 100% means that there is no growth of fungi.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more calculated, that is, sin is rychecky effect.

Table I
Test on Alternaria mali (in vitro)/microtiter plate
Biologically active substancesExpenditure number of biologically active substances in MLNDSEfficiency in percent
OBN.*Races.**
(1-1)0,0351
0,00325
(10-1) Carbendazim0,0315
(15-3) Fenamidone0,0032
(16) Pencycuron0,00311
(1-1)+(10-1) Carbendazim (1:1)0,03+0,037959
(1-1)+(15-3) Fenamidone (1:1)0,003+0,0033527
(1-1)+(16) Pencycuron (1:1)0,003+0,0036733
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example J

Test on Rhizoctonia solani in vitro/microtiter plates

Microtest is carried out with the plates for micrometrology with potato-dextrose nutrient medium as a liquid environment for testing. The use of biologically active substances is carried out in the form of technical A.I., dissolved in acetone.

For inoculation using suspension Michel Rhizoctonia solani. After 5 days of incubation in the dark with constant shaking (10 Hz) on a spectrophotometer to determine the light transmission of each filled cavitation cavity plates for micrometrology.

0% means an efficacy which corresponds to growth of fungi in the case of the control, whereas an efficacy of 100% means that there is no growth of fungi.

From the table below clearly follows that the observed efficiency of the combination of biologists who Eski active substances according to the invention more calculated, i.e. there is a synergistic effect.

Table J
Test on Rhizoctonia solani in vitro/microtiter plate
Biologically active substancesExpenditure number of biologically active substances in millions of sharesEfficiency in percent
OBN.*Races.**
(1-1)0,380
0,140
(14) Fosetyl-Al0,324
(11-1) Propamocarb0,125
(1-1)+(14) Fosetyl-Al (1:1)0,3+0,39885
(1-1)+(11-1) Propamocarb (1:1)0,1+0,188 55
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example K

Test on Septoria tritici (in vitro)/microtiter plates

Microtest is carried out with the plates for micrometrology with potato-dextrose nutrient medium (PDB) as a liquid environment for testing. The use of biologically active substances is carried out in the form of technical A.I. (active ingredient)dissolved in acetone.

For inoculation using a spore suspension Septoria tritici. After 7 days of incubation in the dark with constant shaking (10 Hz) on a spectrophotometer to determine the light transmission of each filled cavitation cavity plates for micrometrology.

0% means an efficacy which corresponds to growth of fungi in the case of the control, whereas an efficacy of 100% means that there is no growth of fungi.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more checking, i.e. there is a synergistic effect.

Table K
Test on Septoria tritici-Test (in vitro)/microtiter plate
Biologically active substancesExpenditure number of biologically active substances in MLNDSEfficiency in percent
OBN.*Races.**
(1-1)0,0115
(13) Triazoxide0,0129
(1-1)+(13) Triazoxide (1:1)0,01+0,016940
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

Example L

Test on Sphaerotheca fuliginea (gherkins)/protective

For the preparation of suitable ready-made preparation of biologically active substance the test substance homogenized in a mixture of acetone/Polysorbate type twin/water. The suspension is diluted with water to the desired concentration.

Plants gherkins (Vert petit de Paris) sow the starter Cup on a 50/50 peat substrate soil - pozzolanic earth and grow at temperatures around 20°C/23°C. At the growth stage 2 leaf plants are sprayed with a ready to use preparation of biologically active substances included spending amounts.

For testing protective aktivnosti plants after 24 hours inoculant aqueous spore suspension Sphaerotheca fuliginea (100000 spores/ml). The plants leaves at a temperature of 20°C/25°C and a relative humidity of 60/70%.

After 21 days after inoculation are evaluated. 0% means an efficacy which corresponds to the control, whereas an efficacy of 100% means that no evidence of any destruction.

From the table below clearly follows that the observed efficiency of the combination of biologically active substances according to the invention more checking, i.e. there is a synergistic effect.

Table L
Test on Sphaerotheca fuliginea (gherkins)/protective
Biologically active substancesExpenditure number of biologically active substances in MLNDSEfficiency in percent
About the. *Races.**
(1-1)860
(6-1) Boscalid850
(1-1)+(6-1) Boscalid (1:1)8+89880
OBN.*= detected effectiveness.
Races.**= efficiency calculated by the Colby formula.

1. Synergistic fungicidal combinations of biologically active substances that contain one carboxamid General formula (I) (group 1)
,
where R1is hydrogen or fluorine,
R2- halogen,
R3is hydrogen or halogen,
And one of the following radicals A1-A2:

where R4- (C1-C3)-alkyl,
R5- (C1-C3-haloalkyl 2 fluorine atoms,
R6is hydrogen,
R7- (C1-C3)-alkyl,
R8- (C1-C3-haloalkyl 2 fluorine atoms,
and the biologically active substance selected from the following groups of compounds:
group (2) Li is Yurinov General formula (II)

where a1- one of the groups

And2Is NH or O,
And3- N or CH,
L - one of the groups

moreover, the chemical bond is indicated by an asterisk (*)attached to the phenyl ring,
R9means phenyl, fenoxaprop or pyridinyl which can be substituted once or twice different residues from the group comprising chlorine, cyano, methyl or trifluoromethyl, or denotes 1-(4-chlorophenyl)-pyrazole-3-Il,
R10is hydrogen or fluorine;
group (3) triazoles of General formula (III)

where Q is hydrogen or SH,
m = 0 or 1,
R11is hydrogen, fluorine, chlorine or phenyl,
R12is hydrogen or chlorine,
And4a simple chemical bond, -CH2-, -(CH2)2or-O-,
And5means,
R13is hydrogen, hydroxy,
R14- 1-chlorocyclopropane, (C1-C4)-alkyl, (C1-C6-hydroxyalkyl,
R13and R14in addition, together denote-O-CH2-CH(R15)-O - or-O-CH(2-chlorophenyl)-,
R15- (C1-C4)-alkyl;
group (4) sulfenamide General formula (IV)

the de R 16is methyl;
group (5) valinamide selected from compounds
(5-1) iprovalicarb,
(5-2) benthiavalicarb;
group (6) carboxamido General formula (V)

where X is 2-chloro-3-pyridinyl, 1-methylpyrazole-4-yl, which is substituted in 3-position by trifluoromethyl, 1-methyl-cyclohexyl or 3,4-dichloroisothiazol-5-Il,
Y is a simple chemical bond or theoffender,
Z - group

or (C1-C6)-alkyl,
And6CH,
R17is hydrogen, chlorine, phenyl, substituted once by chlorine, or cyano,
R18is hydrogen or chlorine,
R19is hydrogen or a hydroxy-group,
group (7) dithiocarbamates selected from a range that includes the connection
(7-1) MANCOZEB,
(7-2) propineb,
(7-3) zineb
group (8) acylalanines General formula (VI)

where * means a carbon atom in R - or S-configuration, preferably in the S-configuration,
R20- benzyl or methoxymethyl;
group (9) of aniline-pyrimidines of General formula (VII)

where R21is methyl, cyclopropyl;
group (10) benzimidazole of General formula (VIII)

where R22and R23each means hydrogen,
R24is hydrogen,
R25- methoxycarbonylamino;
group (11) carbamates of General formula (IX)

where R26 - n - or ISO-propyl,
R27di-((C1-C2)-alkyl)amino-(C2-C4)-alkyl,
including salts of these compounds;
group (12) of dicarboximide representing iprodion;
group (13) imidazole, representing triazoxide;
group (14) phosphonate, representing fosetyl-A1;
group (15) fungicides selected from compounds
(15-1) CHLOROTHALONIL,
(15-2) spiroxamine,
(15-3) fenamidone;
group (16) the derivative of urea, representing pencycuron;
group (17) triazolopyrimidines representing
(17-1) 5-chloro-N-[(1S)-2,2,2-Cryptor-1-methylethyl]-6(2,4,6-tryptophanyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine,
(17-2) 5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-tryptophanyl)[1,2,4]triazolo[1,5-a]pyrimidine-7-amine.

2. The combination of biologically active substances according to claim 1, which contain carboxamid General formula (I) according to claim 1 (group 1),
where R1is hydrogen or fluorine,
R2is chlorine or bromine,
R3is hydrogen or chlorine,
A - A1 or A2,
R4is methyl,
R5- deformity,
R6is hydrogen,
R7is methyl,
R8- deformity.

3. The combination of biologically active substances according to claim 1, in which the biologically active substances of group (2)-(17) selected from the following series of compounds:
(2-1) AZOXYSTROBIN,
(2-2) fluoxastrobin,
(2-3) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoro-4-pyrimidinyl]oxy}Hairdryer is l)-2-(methoxyimino)-N-methylethanamine,
(2-4) Trifloxystrobin,
(2-5) kresoxim-methyl,
(2-6) picoxystrobin,
(2-7) pyraclostrobin,
(3-2) propiconazol,
(3-4) epoxiconazol,
(3-5) prothioconazole,
(3-6) tebuconazole,
(3-7) bitertanol,
(4-1) tolylfluanid,
(5-1) iprovalicarb,
(6-1) boscalid,
(6-3) fenhexamid,
(6-4) 3,4-dichloro-N-(2-cyanophenyl)isothiazol-5-carboxamid,
(6-5) pentopia,
(7-1) MANCOZEB,
(7-2) propineb,
(8-3) metalaxyl-M,
(8-4) benalaxyl-M,
(9-2) Pyrimethanil,
(10-1) carbendazim,
(11-1) propamocarb,
(11-2) propamocarb hydrochloride
(12) iprodion,
(13) triazoxide,
(14) fosetyl-A1
(15-1) CHLOROTHALONIL,
(15-2) spiroxamine,
(16) pencycuron,
(17-1) 5-chloro-N-[(1S)-2,2,2-Cryptor-1-methylethyl]-6-(2,4,6-tryptophanyl)[1,2,4]triazolo[1,5-a]-pyrimidine-7-amine,
(17-2) 5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-tryptophanyl)[1,2,4]triazolo[1,5-a]pyrimidine-7-amine.

4. The combination of biologically active substances according to claim 1, which contain carboxamide (1-1) N-(3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-yl)-3-(deformity)-1-methyl-1H-pyrazole-4-carboxamide (group 1) and a biologically active substance which is selected from groups (2)-(17) according to claim 1.

5. The combination of biologically active substances according to claim 1, which contain carboxamide (1-1) N-(3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-yl)-3-(deformity)-1-methyl-1H-pyrazole-4-carboxamide (group 1) and a biologically active substance which is selected from groups (2)-(17) according to claim 3.

6. The combination of bio is logicheskie active substances according to claim 1, which contain carboxamide (1-4) N-(4'-bromo-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (group 1) and a biologically active substance which is selected from groups (2) and (3) according to claim 1.

7. The combination of biologically active substances according to claim 1, which contain carboxamide (1-4) N-(4'-bromo-1,1'-biphenyl-2-yl)-4-(deformity)-2-methyl-1,3-thiazole-5-carboxamide (group 1) and a biologically active substance which is selected from groups (2) and (3) according to claim 3.

8. The use of combinations of biologically active substances according to claim 1 for combating unwanted phytopathogenic fungi.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to a combined product containing compounds of formula (I): where: R1 and R2 represent CF3; R3 and R4 represent fluoro; R5 and R6 represent hydrogen; R7 presents Cl, X represents CR8, where R8 represents Cl; and R9 represents NH2; or its veterinary acceptable salt, and b) doramectin. The invention also relates to an antiparasitic veterinary composition based on the said combined product.

EFFECT: obtaining a combined product which can be used in veterinary for treating parasitic infections in mammals.

4 cl, 1 dwg, 1 tbl, 37 ex

FIELD: agriculture.

SUBSTANCE: method is described for treatment of wide range of agricultural plants, including spraying of vegetating plants in phase of 5-7 leaf or bushing out or stem elongation by solution of polyhexamethylene guanidine hydrochloride with common formula: which corresponds to molecular mass from 5 to 9 thousand conventional units, with concentration of reactant 0.000001-0.03% and consumption of process solution in dose of 50-250 l per 1 ha, also on herbicide background.

EFFECT: method makes it possible to stimulate growth and development of agricultural plants, and results in improved crop capacity and quality of plant produce.

3 ex, 5 tbl

FIELD: agriculture.

SUBSTANCE: composition to be used as oil for spraying as emulsion in water for control of crop pests and diseases contains from 90 to 98 wt % of paraffin oil processed with hydrogen, the rest is polyglycol ether of oleyl/cetyl alcohol (C16-C18), containing from 3.5 to 6.5 etoxygroups per carbon chain as non-ionic emulsifier and at least one more non-ionic emulsifier selected from sorbitan monooleate, polyoxyethylenesorbitan monooleate and polyoxyethylenemonostearate.

EFFECT: improved stability and efficiency of composition.

3 cl, 19 ex, 2 tbl

FIELD: agriculture.

SUBSTANCE: composition to be used as oil for spraying as emulsion in water for control of crop pests and diseases contains from 90 to 98 wt % of paraffin oil processed with hydrogen, the rest is polyglycol ether of oleyl/cetyl alcohol (C16-C18), containing from 3.5 to 6.5 etoxygroups per carbon chain as non-ionic emulsifier and at least one more non-ionic emulsifier selected from sorbitan monooleate, polyoxyethylenesorbitan monooleate and polyoxyethylenemonostearate.

EFFECT: improved stability and efficiency of composition.

3 cl, 19 ex, 2 tbl

FIELD: agriculture.

SUBSTANCE: here is disclosed growth stimulating agent containing as active ingredient hexa-hydro-1,2,4-triazonine-3 of formula

EFFECT: increased productivity of agricultural crops.

3 tbl, 5 ex

Antibacterial agent // 2379890

FIELD: agriculture.

SUBSTANCE: invention refers to agriculture, particularly to veterinary medicine and can be implemented for disinfection of objects of veterinary inspectorate. Antibacterial agent contains iodine, nitrate of potassium, N-chlorsuccinimide, and starch at following ratio of components, wt %: iodine - 28-36; nitrate of potassium - 36-42; N-chlorsuccinimide - 8-12, starch - the rest. The agent is efficient for preventive sanitation of air and premises and also facilitates affecting all kinds of bacteria, fungi, and virus, including mycobacteria.

EFFECT: invention increases biocide activity and reduces rates of application ensuring pyrotechnic safety.

9 ex

Novel insecticides // 2379301

FIELD: chemistry.

SUBSTANCE: compounds with formula I are described, where each of E and Z is oxygen; A is C1-C6alkylene or a 3-member monocyclic ring system, which can be monosubstituted; Y is C1-C6alkylene; p equals 0; q equals 0 or 1; B represents a 3- or 4-member ring system which is completely or partially saturated and can contain a heteroatom selected from oxygen, possibly substituted; each R1 independently represents halogen, nitro group, C1-C6alkyl; or each R1 independently represents an amino group; n equals 1, 2; each of R2 and R3 represents hydrogen; D represents a group and agronomically acceptable salts of said compounds. Also described is a method of producing formula I compounds, intermediate compounds, a pesticide composition containing a formula I compound, as well as an insect control method and a method of protecting plant propagation material.

EFFECT: novel anthranylamide derivatives have good insecticidal activity.

16 cl, 8 tbl, 19 ex

FIELD: chemistry.

SUBSTANCE: invention relates to [2-(azol-1-yl)alkylbenzimidazol-1-yl]alkanoic acids and their esters of general formula I, where Z and Y represent a nitrogen atom or a CH-group, or are simultaneously a C-CH=CH-CH=CH-C chain, together consisting of an annelated ring, n and m are equal or different and assume integer values from 1 to 3, R is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms, except [2-(1H-benzimidazol-1-ylmethyl)-1H-benzimidazol-1-yl]acetic acid. The said compounds with general formula I are obtained through alkylation of 2-(azol-1-ylalkyl)benzimidazoles II with esters of ω-halogenalkanoic acids alkylacrylates and γ-butyrolacton in polar aprotonic and protonic solvents in the presence of carbonates of alkali metals, as well as when using interphase transfer catalysts. The invention also relates to a growth-regulating composition based on compounds of general formula I.

EFFECT: use of the derivative in the growth-regulating composition allows for achieving a growth retardant effect.

6 cl, 7 tbl, 9 ex

FIELD: agriculture.

SUBSTANCE: aerosol drift in process of pesticide spraying is reduced by a) addition of 0.1-10 vol. % of monosaccharide or mixture of monosaccharides into pesticide solution for spraying and b) spraying of produced mixture from sprayer with flat spray or from forward-flow sprayer without deflector.

EFFECT: increased average size of produced drops and reduced percentage of drops formation with size below 150 mcm.

13 cl, 1 ex, 1 tbl

FIELD: agriculture.

SUBSTANCE: aerosol drift in process of pesticide spraying is reduced by a) addition of 0.1-10 vol. % of monosaccharide or mixture of monosaccharides into pesticide solution for spraying and b) spraying of produced mixture from sprayer with flat spray or from forward-flow sprayer without deflector.

EFFECT: increased average size of produced drops and reduced percentage of drops formation with size below 150 mcm.

13 cl, 1 ex, 1 tbl

FIELD: chemistry.

SUBSTANCE: description is given of a fungicide composition containing a) a pyridylethylenebenzamide derivative with general formula (I), where p equals 2, q equals 1, each substitute X is independently chosen and is a halogen, halogenalkyl, containing 1-5 carbon atoms, Y is a halogenalkyl, containing 1-5 carbon atoms, and b) a compound, capable of inhibiting spore germination or growth of micellium through effect on different metabolic routes, which is iprodione, captan, folpet, 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2pyridinyl]}benzamide, benalaxyl, chlorothalonil, fludioxonil, mankozeb, metalaxyl-M, propamocarb, propineb, tolylfluanid, fosetyl-A1, with mass ratio (a)/(b) between 0.04 and 9. A method is also described for preventive or remedial control of phytopathogenic fungi in crops.

EFFECT: composition provides synergetic effect.

9 cl, 1 tbl, 1 ex

FIELD: organic chemistry, fungicides.

SUBSTANCE: invention describes a composition used for control over diseases in plants caused by plant fungal pathogens and comprising: (a) compounds of the formula (I): wherein A means pyridinyl ring substituted with at least one substitute chosen from halogen atom and (C1-C6)-halogenalkyl; B means phenyl ring possibly substituted with halogen atom; W represents C=L wherein L means oxygen atom (O); R1, R2 and R3 mean hydrogen atom (H), and (b) at least one compound chosen from group consisting of (b1) alkylene-bis-(dithiocarbamate) fungicides, (b2) compounds effecting on bc1-complex of electron transfer site in fungal mitochondrial respiratory system, (b3) cimoxanil, and (b9) fosetil-aluminum in the mass ratio of component (b) to component (a) from 100:1 to 1:100. Also, invention describes a method for control over plant diseases.

EFFECT: improved and valuable properties of compounds and compositions.

13 cl, 18 tbl, 11 ex

Herbicide agent // 2303872

FIELD: organic chemistry, herbicides.

SUBSTANCE: invention describes a herbicide agent comprising a combination of active components consisting of (a) substituted thene-3-ylsulfonylaminocarbonyl triazolinone of the general formula (I) wherein R1 means alkyl with 1-6 carbon atoms; R2 means alkyl with 1-6 carbon atoms; R3 means alkyl, alkoxy-, alkylthio-group with 1-6 carbon atoms, cycloalkyl with 3-6 carbon atoms; R4 means alkyl with 1-6 carbon atoms, cycloalkyl with 3-6 carbon atoms, or its salt, and (b) compound chosen from group of herbicides given in the description and taken in the synergetic ratio. The proposed agent shows synergetic effect.

EFFECT: valuable property of herbicide agent.

6 cl, 107 tbl, 1 ex

FIELD: agriculture.

SUBSTANCE: invention relates to composition containing pirimetanyl and phosetyl-Al in weight ratio of 0.05-10 and method for healing and prophylaxis controlling of plant phytopathogenic organisms using the same. Application of phosetyl-Al to prolong pirimetanyl action also is described.

EFFECT: decreased treatment process number which is necessary to control disease progress.

8 cl, 1 ex

FIELD: organic chemistry, agriculture.

SUBSTANCE: invention relates to incecticidal/acaricidal agent of synergetic action having general formula I wherein W, Y and Z are independently hydrogen or C1-C4-alkyl; A and B together with carbon atom to which they are bonded form C3-C6-cycloalkyl monosubstituted with C1-C4-alkoxyl; G is carbon or -COOR, wherein R is C1-C4-flkyl and compound selected from group containing chloropyriphos, oxydimenton methyl, acephat, methiocarb, thiocarb, pyrimicarb in synergic ratio.

EFFECT: agent of high efficiency to control pests and mites.

2 cl, 8 tbl, 7 ex

The invention relates to the production of pesticides

The invention relates to a new compound exhibiting fungicidal activity

FIELD: agriculture.

SUBSTANCE: proposed synergetic effect herbicide compound contains efficient amounts of components (A) and (B), with (A) standing for a single or multiple herbicide substance(s) with general formula as well as salts thereof and (B) standing for a single or multiple herbicide substance(s) that are used for selective control of monocotyledonous and/or dicotyledonous weeds with monocotyledonous cultivated plants and belong to the compounds group including: (B1) flucarbazon, (B2) BAY MKH 6561 (procarbazon), (B3) florasulam, (B4) halosulphuron, (B5) tritosulphuron, (B6) pikolinafen, (B7) cinidon-ethyl, (B8) mezotrion, (B9) metosulam, (B10) cloryralid, (B11) flufenacet, (B12) flumetsulam, (B13) flupoxam, (B14) prosulphocarb, (B15) flutramon, (B16) aclonifen, (B17) hexazinon, (B18) asulam, (B19) diuron, (B20) amertin, (B21) izoxaflutol, (B22) amicarbazon, (B23) trifloxisulphuron; excluded are the herbicide compounds whose (A) component is one or several herbicide substances belonging to the (I) general formula group as well as salts thereof where R1 is (C1-C8)-alkyl, (C3-C4)-alkenyl or (C3-C4)-alkinyl, R2 is CH2NHSO2CH3, R3 is metoxi and Z is CH, and (B) component is one or several herbicide substances belonging to the compounds group including (B9), (B13), (B14) and (B15).

EFFECT: quantitative minimisation of specific agents application.

7 cl, 8 tbl, 4 ex

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