Method for blood microvesicle correction in arterial hypertension and pancreatic diabetes type ii

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology and concerns correction of blood microvesicle level in arterial hypertension (AH) and pancreatic diabetes type II (PD II). That is ensured by integrated therapy involving graduated physical exercises, as well as introduction of lisinopril in a dose 10 mg once in the morning, amlodipine in a dose 5 mg once in the morning and pioglitazone in a dose 30 mg once in the morning for therapeutic course at least 7 weeks.

EFFECT: complex of specific medical preparations and physical exercises combined with empirically specified duration of treatment provides effective correction of blood microvesicle level and, thereby, reduced risk of thrombotic complications in given group of patients.

1 ex

 

The invention relates to medicine, namely to Hematology, cardiology and endocrinology.

Analogues of the proposed method of correction of the level of microvesicles in the blood with arterial hypertension (AH) and diabetes mellitus type II (DM type II) does not exist.

It is known that an important feature of the cytoplasmic membrane is asymmetric phospholipid and protein composition of the two leaflets of the bilayer, which occurs under the action of intracellular enzymes, differences in the ionic composition of the cytoplasm and the extracellular fluid. The asymmetry of the bilayer determines thrombogenicity and hemocoagulation properties of blood cells and endothelium of blood vessels and, in addition, participates in the creation of the gradient of curvature of the folds, morsiani, outsoruce areas of the membrane in the form of microvesicles.

Formed by exocytosis, necrosis and apoptosis fragments of cell membranes are able to withdraw and form bubbles with a diameter of from 0.05 to 3.0 μm. The size of the microvesicles depends on the nature of the agent acting on the target cell. Microvesicles are platelet and nitrobacteria origin. They are formed on the cell surface, lusiwasi with the cytoplasmic membrane. Therefore, they contain various membrane glycoproteins, proteins of the cytoskeleton, fibers, chains of myosin, etc.

Microvesicles not only presented Aut catalytic surface for internal tenaz" (supramolecular complex, consisting of factor IXa, factor VIIIa, and phospholipids) and prothrombinase complex, but also able to influence the proteolytic inactivation of factors Va and VIIIa by activated protein C in combination with protein S. Therefore reducing the level of microvesicles in the blood leads to reduction of hemocoagulation potential estramboticos blood plasma.

When hypertension and diabetes type II increased blood level of microvesicles, causing the increase of coagulation opportunities plasma. However, approaches to reduce the level of microvesicles in the blood in hypertension and diabetes type II remain very poorly developed. In patients with hypertension and type II DM to reduce blood pressure are applied ACE inhibitors and calcium antagonists (B.C. Zadionchenko and other Arterial hypertension in the metabolic syndrome: pathogenesis, therapy basics". Consilium medicum 2004, Vol.6, No. 9, http://www.voed.ru/art.gip.metab.sindr.htm). For the correction of diabetes type II can be used pioglitazone and physical activity.

However, never before medical complex consisting of dosed physical activity, lisinopril, amlodipine, and pioglitazone, have not been applied in patients with hypertension and type II DM to reduce the level of microvesicles.

The aim of the invention is the lowering of the level of microvesicles in the blood of patients with hypertension and diabetes type II.

The essence of the proposed method lies in the fact that the corre is the level of microvesicles in the blood of patients with hypertension and type II DM for at least 7 weeks assigned lisinopril 10 mg 1 every morning, amlodipine 5 mg 1 every morning and pioglitazone 30 mg 1 every morning on the background of the dosed physical load.

The method allows to adjust the level of microvesicles in the blood of patients with hypertension and type II DM for at least 7 weeks, putting it on a level close to that of healthy people. Subject to the subsequent recommendations of the proposed method it is possible to maintain the level of microvesicles at the optimal level, which will significantly reduce the risk of thrombotic complications, reduce the number of cases of temporary disability, to expedite patient treatment and improve the quality, reduce disability, and also to prolong the life and reduce mortality of patients with hypertension and type II DM from heart attack and stroke.

The inventive method is carried out as follows.

Establishing the level of blood microvesicles carry out activity 5-nucleotidase in serum (Ldzierba, Dimswart, Ihantola and other Cellular microvesicles in the dynamics of experimental endotoxinemia. // Bulletin of experimental biology and medicine: monthly international scientific-theoretical journal / RAMS. - 2006. Tom. 142, No. 11. - S-520). OK its level representing 63.8±2,5 ncat. When the level of microvesicles in the blood of patients with hypertension and type II DM should prescribe lisinopril 10 mg 1 every morning, amlodipine 5 mg 1 every morning is pioglitazone 30 mg 1 every morning on the background of the dosed physical activity. One possible example of the latter is given below.

Physical activity in the real conditions of life are carried out in three forms: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics should go is to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, patients are recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of lightweight option exercise, then the enhanced version.

2. Complexes of preventive and curative gymnastics.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touching the rights of the second hand of the left sock. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original floor is laid. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands down. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on p. the Lu; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (e) self-massage of the abdomen small polukrugom movements clockwise-1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing with arms lowered the. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt societat the exhale, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage and delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight but the AMI - "scissors". 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Dihan is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

The patient with hypertension and type II DM is sick with a number of related disorders, primarily the cardiovascular system. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why increasing the physical activity of persons suffering from the G and type II DM, should be done by the distribution of physical activity in small doses throughout the day.

This method of increasing physical activity in patients with hypertension and type II DM should be considered as a method of fractional loads.

Depending on the conditions of real life in patients with hypertension and type II DM can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or moving placed on the Yu - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

Example. Patient G., 51, AG 2 degree, 2 stage (blood pressure 165/100 mm Hg) and type II DM (fasting glucose of 6.8 mmol/l) during examination revealed an increased level of microvesicles in blood plasma 224,1 ncat. The patient was prescribed lisinopril 10 mg 1 every morning, amlodipine 5 mg 1 every morning and pioglitazone 30 mg 1 every morning on the background of the dosed physical activity. The patient was regularly looked after the start of treatment. Simultaneously with the inspection was carried out to determine the level of blood microvesicles.

After 7 weeks of treatment, the patient's blood pressure stabilized at 125/80 mm Hg, fasting glucose amounted to 5.4 mmol/l at normal levels, blood microvesicles comprising 61,2 ncat.

The patient is asked to comply with these recommendations in future.

The use of the proposed method of correction of the level of microvesicles blood Hematology, cardiology and endocrinology will help to avoid many of the vascular complications in patients with hypertension and type II DM, reduce their number of cases of temporary nerudas is osobnosti, to reduce the duration of hospitalization, reduce morbidity and mortality.

The correction method of the level of microvesicles in the blood in hypertension and diabetes mellitus type II by applying lisinopril 10 mg 1 every morning, amlodipine 5 mg 1 every morning, pioglitazone 30 mg 1 every morning and dosed physical activity for at least 7 weeks.



 

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1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to 5-methoxy-2-(((4-methoxy-3-methyl-2-pyridinyl)methyl)sulfinyl)-6-methyl-3H-imidazo[4,5-b]pyridine or to its salt, as well as a pharmaceutical composition which inhibits secretion of gastric acid based on the said compound. Description is given of production of the new compound and a pharmaceutical composition based on the new compound, which can be used in medicine for treating such diseases as gastric ulcer, duodenal ulcer, stomal ulcer, gastroesophageal reflux, Zollinger-Ellison syndrome, symptomatic gastroesophageal reflux, endoscopy negative gastroesophageal reflux, gastroesophageal regurgitation, pharyngolaryngeal paresthesia, Barrett's esophagus, Non-steroidal anti-inflammatory drug (NSAID) induced ulcer, gastritis, gastric hemorrhage, gastrointestinal hemorrhage, peptic ulcer, bleeding ulcer, stress ulcer, gastric hyperchlorhydria, dyspepsia, gastroparesis, senile ulcer, intractable ulcer, heartburn, bruxism, stomach ache, heavy stomach or erosive gastritis.

EFFECT: increased effectiveness of composition and disease treatment.

7 cl, 6 tbl, 29 ex

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