Method for preparing common valerian alcoholate
SUBSTANCE: invention refers to chemical-pharmaceutical and medical industry. Common valerian roots and rhizomes are extracted in 70% ethyl alcohol with following filtration of the extract from herbal raw material. Extraction is aided with ultrasonic waves of frequency 30 kHz and intensity 365-370 Wt/cm2 during 18-20 minutes at temperature 25-27°C at the relation of herbal raw material to 70% ethyl alcohol as 1:10.
EFFECT: invention allows improving yield and reducing preparation time of the product.
2 cl, 1 dwg, 1 tbl, 1 ex
The invention relates to chemical-pharmaceutical and medical industry, in particular to methods of obtaining funds for the prevention and treatment of nervous diseases.
The use of herbal remedies for the prevention and treatment of various diseases has a high degree of safety with sufficient efficiency, the possibility of a more prolonged usage, which is important for the correction of patients with chronic diseases. Drugs from medicinal plants are recommended not only for patients but also healthy people for prevention of various diseases, improve the body resistance and correction of violations, on the verge of health and disease. Proper selection of medicinal plants in accordance with the individual characteristics of the patient and the specifics of the disease can significantly improve the patient's condition.
In modern medical practice Valerian tincture is prescribed for diseases involving the nervous agitation, insomnia, migraine headaches, hysteria. Especially widely used Valerian in milder forms of neurasthenia, pre - and menopausal disorders, vegetarisch, the neuroses of the cardiovascular system, as well as for prevention and treatment of early stages of angina, hypertension is a disease, in some diseases of the liver and biliary tract, diseases, accompanied by cramps of the stomach and intestines with impaired secretion. Tincture of Valerian reduces the excitability of the Central nervous system and calming effect is slowly but steadily. Patients relieves tension, irritability, and improved sleep.
Despite the considerable range of herbal remedies that have sedative effects, tincture of Valerian, due to its popularity remains the most widely used among them means. The effect of the drug depends on the content of essential oil, much of which is an ester of borneol and isovalerianic acid. The drug facilitates the onset of natural sleep and deepens it. Valeric acid contained in the product, has a weak spasmolytic action. The drug is virtually feelings of fatigue, does not affect mental and physical performance.
Closest to the claimed invention is a method for Valerian drug by extraction of raw materials in 70% ethyl alcohol and subsequent filtration of the extract from the plant material. The extraction was performed at room temperature 20÷22°C for three days. The extraction was taken as the ratio of raw material: the former is Regent 1:10 (by weight). As raw materials use the roots and rhizomes of Valerian. (The state Pharmacopoeia of the USSR).
The disadvantage of this method lies in the fact that to receive infusions need quite a long maceration of raw materials in the extractant is ethanol, which should be performed within 3 days, and incomplete extraction of valuable components.
The objective of the invention is to intensify the process of extraction and reducing costs.
The technical result of this method is the increase in the yield and quality of the target product, as well as the reduction of the process time of receipt of the tincture Valerian.
The task and the specified technical result is achieved by the fact that in the method of obtaining Valerian drug, including extraction of roots and rhizomes of Valerian in 70% ethyl alcohol, filtering the extract from the plant material according to the invention the extraction is performed under the influence of ultrasonic waves with a frequency of 30 kHz and an intensity of 365÷370 watts/cm2the extraction process should be performed within 18÷20 minutes. Ultrasonic treatment is carried out at a temperature of 25÷27°C, while the ratio of vegetable raw materials and 70% ethanol 1:10.
The use of ultrasound with a frequency of 30 kHz can significantly reduce the time required for the teachings of tincture Valerian, and also to increase the yield of valuable components, providing its action. When using ULTRASOUND with a frequency below 30 kHz output of biologically active substances is reduced, the use of ultrasound with a frequency above 30 kHz impractical due to excessive power consumption. Use as a solvent of ethanol is associated with its food and pharmaceutical application.
The use of ultrasound with intensity 365÷370 watts/cm2ensures the achievement of the technical result - improving product yield and reducing the time of its receipt. When using lower intensities of ultrasound exposure time is increased to achieve a technical result, and the increased intensity leads to destruction allocated pectin.
The time of ultrasonic treatment is 18÷20 min and is optimal for maximum output valerianic acid. Reducing the time to achieve the desired output, and the increase in the duration of ultrasonic treatment leads to the destruction of biologically active substances. The invention eliminates a long maceration of plant raw materials and to reduce the time of receipt of Valerian tincture. The implementation of this method allows to reduce time of processing of raw materials, because in this implementation of the method is the need to pre-soak.
Conducting the process at a temperature of 25÷27°C allows to achieve the project objectives, in addition, at a given temperature does not occur inactivation of valerianic acid, which allows you to get a quality product.
The ratio of vegetable raw materials and 70% ethanol 1:10 is the most appropriate because it provides the most complete extraction of valerianic acid from vegetable raw materials.
Determining the authenticity of the extracts obtained by conventional infusion and using ultrasonic extraction was performed according to the Pharmacopoeia. This made the determination of the content of valerianic acid and the dry residue.
The invention is illustrated in the drawing, which depicts the dependence of the content of valerianic acid from the timing and intensity of ultrasonic influence.
The inventive method of obtaining tincture Valerian was carried out as follows. Ultrasonic generator configured according to the intensity, the hanging plant materials were placed in a chemical glass and filled with ethyl alcohol (70%), after which the nozzle of the generator was loaded into a glass and raw materials were subjected to ultrasound. After ultrasonic extraction the plant material was separated by filtration.
Optimal conditions of the experiment were determined based on the content Valerie is a new acid in solution. Too powerful ULTRASONIC or too long exposure time destroy valeric acid, as evidenced by the reduction of its content in the obtained extracts.
Took the hanging roots with rhizomes of Valerian 5 g were placed in a chemical beaker was filled with ethanol (70%) 50 g (1:10). Ultrasonic treatment of the extracts was performed using an instrument IKASONIC U 50 control (30 kHz). The nozzle of the generator of ULTRASONIC waves was immersed in the chemical glass. Ultrasonic effect on the solid plant material was carried out with an intensity 368 watts/cm2within 20 minutes.
After processing is completed, the solution was filtered through a layer of gauze.
Then there was the determination valerianic acid and the dry residue. The temperature of extraction 25°C.
The content of valerianic acid 0,39%.
The experiment was carried out analogously to example 1 except that the ultrasonic treatment was carried out with an intensity of 350 W/cm2within 20 minutes.
The content of valerianic acid of 0.15%.
Therefore, the decrease of intensity of ultrasonic treatment leads to a decrease in the content of valerianic acid.
The experiment was carried out analogously to example 1 except that the ultrasonic treatment was carried out with an intensity of 380 watts/cm2within 20 minutes.
The contents of the shaft is Lanovoy acid 0,11%.
Therefore, increasing the intensity of ultrasonic treatment leads to reduction of the yield of pectin.
Based on these examples we can draw the following conclusions: the optimal conditions of ultrasonic influence is the intensity of 365÷370 watts/cm2and the processing time is 18÷20 minutes.
The table presents the comparison of traditional method and declare under optimal conditions.
|Comparing the effectiveness of traditional soaking and ULTRASONIC extraction in obtaining a medical tincture Valerian|
|Indicators||Traditional maceration||ULTRASONIC extraction (under optimal conditions)||GFK*|
|3 days||20 minutes|
|The content of valerianic acid, %||0,23||0,39||not less than 0,2%|
|The dry residue, %||3,3||3,5||at least 3%|
|∗)GFK - State Pharmacopoeia|
This method will speed up the process of tincture Valerian and reduce the cost of its receipt, to improve the yield and quality of the target product, which is determined by the content of valerianic acid.
This invention is in the stage of laboratory research.
1. The method of obtaining Valerian drug, including extraction of roots and rhizomes of Valerian in 70%ethyl alcohol, filtering the extract from the plant material, characterized in that the extraction is carried out at an additional influence of ultrasonic waves with a frequency of 30 kHz and intensity 365-370 W/cm2the extraction process is carried out in air for 18-20 minutes at a temperature of 25-27°C.
2. The method according to claim 1, characterized in that the ratio of vegetable raw materials and 70%ethanol 1:10.
SUBSTANCE: air-dry crushed wood greens of fir is extracted twice with tret-butylmethyl ester. Extract is separated from needles and treated with 2% NaOH solution with further separation of organic and water layers. Water-alkali layer is acidified and formed organic phase representing sum of triterpene acids is separated. Organic layer is concentrated by extragent distillation, treates with hot water and volatile agents of fir oil are hydrodistilled at under pressure 0.1-0.3 atm and temperature not higher than 50°C. Vat residue is hydrolysed by boiling with water-alcohol alkali and neutral hydrolysate components are separated by solvent distillation at lowered pressure and temperature not higher than 80°C with further double extraction with methyl-tret-butyl ester, 2-3-time washing of obtained layer with water to neutral reaction and evaporation. Water-alcohol solution is acidified with 5-10% solution of hydrochloric acid to pH 2 and extracted with tret-butylmethyl ester. Extract is washed with water to neutral pH and ester is distilled under pressure 0.1-0.3 atm and temperature not higher than 80°C obtaining the product.
EFFECT: invention allows to realise said purpose.
7 ex, 6 tbl
SUBSTANCE: raw material is grinded that is followed with vacuum ultrasonic extraction with 80% ethyl alcohol at 18-20°C.
EFFECT: invention allows simplifying the process and improving product purity.
SUBSTANCE: invention relates to household chemistry, medicine, cosmetic-fragrance industry. Material is extracted using aqueous propyleneglycol extracting agent in a rotor-pulse apparatus without presoaking in continuous circulation mode with ratio of plant material to extraction agent ranging from 1:10 to 1:20 and rotor speed of 3600 to 4400 rpm for 5 to 15 minutes at 25 to 55°C with subsequent filtering off the solid plant part. 1,2-propyleneglycol with water content ranging from 0.1 to 95 wt % is used.
EFFECT: invention allows for cutting on extraction time and obtaining extract with high content of flavonoids (by 20 to 40%) and high resistance to microbiological pollution.
2 cl, 3 tbl, 20 ex
SUBSTANCE: invention relates to the chemical and pharmaceutical industry. Schizandra seeds are extracted using 70-90% ethyl alcohol first at room temperature and then while heating at temperature between 65-70°C.
EFFECT: invention increases output of active substances.
2 ex, 1 tbl, 1 dwg
FIELD: wood working industry.
SUBSTANCE: invention relates to wood chemical industry. Waste wood of aspen is chopped till particle size is less than 1 mm, is dried on air till moisture content is not more than 18%, raw material is watered at a temperature of 18-25°C with the following ratio of the raw material: extractant = 1:1.5-2.5, within 10-24 hours, further mechanical pressing of extractant and concentrating it in a vacuum at a temperature of not higher than 40°C till content of total solids is from 3.5 to 100%.
EFFECT: invention allows fulfilling the specified purpose.
10 ex, 3 tbl
SUBSTANCE: method for making cream-gel of celandine extract includes selection of fresh blooming and fruit ripening plants, then milled to vegetation debris, put into an opaque container with glass walls and kept under certain conditions. During this period, fogging-off plants are irrigated once or twice with a standard end extract from previous collections. Then the whole debris is filled in with boiled water and further fermented (liquid phase) to eliminate smell. Liquid is separated from vegetation debris, spilled in an ajar glass, kept under certain conditions, at first filtered through the usual filter, and then through the ultrafilter membrane, added to a liquid crystal cream-gel base.
EFFECT: cream-gel of celandine extract with effective therapeutic action.
2 cl, 1 ex
FIELD: food industry.
SUBSTANCE: invention relates to technology of manufacturing coffee substitute. Method provides for extraction of allspice by liquid nitrogen with corresponding miscella separation, preparation of girasol, its cutting, drying in microwave field during at least one hour till residual humidity not less than 20% at microwave filed power providing temperature inside the bits up to 80-90°C, frying, impregnation of separated miscella providing pressure boost, depressurisation till atmosphere pressure with girasol freezing and its cryomilling in medium of exuded nitrogen.
EFFECT: method provides for production of coffee drink according to nonwaste technology.
FIELD: food products.
SUBSTANCE: method provides for extraction of red tea by liquid nitrogen with corresponding miscella separation, preparation of girasol, its cutting, drying in microwave field during at least one hour till residual humidity not less than 20% at microwave filed power providing temperature inside the bits 80-90°C, frying, impregnation of separated miscella providing pressure boost, depressurisation till atmosphere pressure with girasol freezing and its cryomilling in medium of exuded nitrogen.
EFFECT: production of coffee drink according to nonwaste technology.
FIELD: food products.
SUBSTANCE: method provides for extraction of jeera by liquid nitrogen with corresponding miscella separation, preparation of girasol, its cutting, drying in microwave field during at least one hour till residual humidity 20% at microwave filed power providing temperature inside the bits 80-90°C, frying, impregnation of separated miscella providing pressure boost, depressurisation till atmosphere pressure with girasol freezing and its cryomilling in medium of exuded nitrogen.
EFFECT: production of coffee drink according to nonwaste technology.
FIELD: food products.
SUBSTANCE: method provides for extraction of cardamom by liquid nitrogen with corresponding miscella separation, preparation of girasol, its cutting, drying in microwave field during at least one hour till residual humidity 20% at microwave filed power providing temperature inside the bits 80-90°C, frying, impregnation of separated miscella providing pressure boost, depressurisation till atmosphere pressure with girasol freezing and its cryomilling in medium of exuded nitrogen.
EFFECT: production of coffee drink according to nonwaste technology.
SUBSTANCE: invention refers to medical products and concerns applications of a film for internal application containing triprolidine or its salt, or hydrate, as an active component of the remedy for awakening vigorous after sleeping. There is also disclosed method for treatment or prevention of sluggishness or somnolence in awakening after sleeping, the method that makes it possible for an individual to wake up vigorous after sleeping and the method ensuring falling asleep of an individual.
EFFECT: invention aims at development of the agent that makes it possible for an individual to wake up vigorous after sleeping.
19 cl, 5 tbl, 2 ex
SUBSTANCE: invention refers to chemical-pharmaceutical industry and medicine, namely to an oral gindarine tranquiliser. There is offered composition for capsule containing as an active substance, gindarine in the form of gindarine hydrochloride, and an adjuvant chemically inert to the active substance and physiologically acceptable or number of adjuvants enabling prolonged release of gindarine hydrochloride. The composition represents granules, or mixed powders, or mixed granules and powder, or liquid, or soft form. As adjuvants, the composition contains an excipient, alone or combined with a disintegrant, or an antifriction substance, or a binding substance, or mixture thereof. The composition representing the liquid form - suspension, or the soft form - gel, as adjuvant contains a liquid base, alone or mixed with a thickener or a preservative, or mixture thereof.
EFFECT: according to the invention the composition is characterised by prolonged release of gindarine from oral dosage capsular form.
10 cl, 18 ex
SUBSTANCE: invention refers to medicine and pharmacology and presents a pharmaceutical composition based on alpha-lipoic acid as an aqueous solution for injections, for treatment and/or prevention of a disease chosen from group including alcoholic and/or diabetic polyneuropathy, coronary atherosclerosis, hyperlipidemia, hyperlipoproteinemia, mild and moderate viral hepatitis type A, hepatic cirrhosis, heavy metal salts poisoning, intoxications of various aetiologies, differing that it contains ethylenediamine, propylene glycol, solubiliser presented with plasdone, water for injection or 0.9% NaCI solution for injection in a certain relation components in the composition.
EFFECT: invention provides improved stability and absence of sediment in the solution, as well as extended range of products.
5 cl, 1 ex, 1 tbl
SUBSTANCE: invention refers to medicine, namely to neurology, and can be used in treatment of the patients with diskogenic radiculopathy of lumbosacral spine. That is ensured by intravenous drop infusion of the mixed medicinal preparations containing 2.4% aminophylline 5-10 ml, dexamethasone 8-16 mg per 100 ml of 0.9% sodium chloride brine at rate 30-35 drops per minute during 4-5 days. Upon termination of the infusion, lasix 20-40 mg is added to the mixture. Then 30 minutes after introduction of the mixture, manual therapy follows as postisometric relaxation of posterior muscles of thigh. Starting from the 2-3 day of introduction of the mixture, postisometric relaxation is combined with mobilisation and manipulations within lumbosacral spine.
EFFECT: method allows improving clinical effectiveness in such patients owing to integrated effect on various links of pathogenesis.
2 tbl, 2 ex
SUBSTANCE: invention concerns new biologically active compound peptide possessing protective action against Alzheimer's disease of formula Glu-Trp-Asp-Leu-Val-Gly-Ile-Pro-Gly-Lys-Arg-Ser-Glu-Arg-Phe-Tyr-Glu-Cys-Cys-Lys-Glu.
EFFECT: can be used to produce a preparation for immunoprophylaxis of Alzheimer's diseases.
1 tbl, 2 ex
SUBSTANCE: invention relates to new compounds with formula I: , where D is O; E is CH2 or O; n equals 1 or 2, and R1 is chosen from hydrogen, halogen or substituted or unsubstituted 5- or 6-member aromatic or heteroaromatic ring with 0, 1 or 2 nitrogen atoms, 0 or 1 oxygen atom, or is chosen from substituted or unsubstituted 8-, 9- or 10-member condensed heteroaromatic ring system with 0 or 1 nitrogen atom, 0 or 1 oxygen atom, where the said aromatic or heteroaromatic rings or ring systems, when they are substituted, have substitutes which are chosen from -C1-C6alkyl, -C3-C6cycloalkyl, -C1-C6alkoxy, halogen, -CF3, -S(O)mR2, where m equals 0, 1 or 2, -NR2R3, -NR2C(O)R3 or -C(O)NR2R3; R2 and R3 are in each case independently chosen from hydrogen, -C1-C4alkyl, -C3-C6cycloalkyl, aryl; or its stereoisomers, enantiomers or pharmaceutically acceptable salts; under the condition that the given compound is not 2-(1-aza-bicyclo[2.2.2]oct-3-yl)-2,3-dihydroisoindol-1-one. The invention also relates to compounds with formulae II or III, to a pharmaceutical composition, as well as to use of compounds in paragraph 1.
EFFECT: obtaining new biologically active compounds with activity towards alpha 7 nicotinic acetylcholine receptors (α7 nAChRs).
8 cl, 72 ex, 1 tbl
SUBSTANCE: present invention relates to a tetrazole compound with general formula I , where X3 and X4 are independently N and C, where one of X3 and X4 is certainly C; P is phenyl; m equals 1 or 2, where if m equals 1, R1 is bonded to P through a carbon atom on ring P in the meta-position of ring P relative the point at which P is bonded to X3, and if m equals 2, R1 is bonded to P through a carbon atom on ring P in positions 2 and 5 of ring P; R1 is halogen, C1-6alkyl, OC1-6alkyl or cyano group; X1 is C2-3alkyl, C2-3alkenyl, NR3, O, S, CR3R4, SO, SO2; X2 is a bond, CR3R4, O, S, NR3, SO, SO2; R3 and R4 are independently chosen from a group which consists of hydrogen, hydroxy, C1-6alkyl; Q is triazolyl, piperazinyl, or triazole or imidazole ring, condensed with a 6- or 7-member heterocyclic ring with one or two N atoms as heteroatoms; R is C1-6alkyl, C3-6cycloalkyl, pyridinyl, which can be substituted with a nitro, cyano, halogen or OC1-4alkyl group; phenyl, which can be substituted with a halogen, C1-4alkyl, OC1-4alkyl group; (CO)OC1-4alkyl; pyrimidinyl, which can be substituted with a OC1-4alkyl group; p equals 0, 1 or 2, or pharmaceutically acceptable salt or hydrate thereof.
EFFECT: invention also relates to method of inhibiting activity of mGluR5 receptors.
11 cl, 44 ex
SUBSTANCE: present invention relates to new compounds of formula I: , where m ranges from 0 to 3, n ranges from 1 to 3, p is 0, Ar is phenyl, possibly substituted with C1-C6-alkyl, cycloalkyl, hydroxyalkyl, halogen, hydroxyl or cyano group, X is -O-,R1 and R2 each is independently hydrogen, C1-6alkyl or C1-6alkoxy-C1-6alkyl or hydroxy-C1-6alkyl, or one of R1 and R2 is hydrogen or C1-6 alkyl, and the other is C1-6alkylcarbonyl, C3-C8 cycloalkyl, aryl-C1-6alkyl or hydroxyl, or R1 and R2 together with the nitrogen atom to which they are bonded can form a three- to seven-member ring, which can possibly contain an additional N heteroatom, or R1 and R2 together with the nitrogen atom to which they are bonded can form a guanidyl group, amidinyl group, carbamyl group or urea group, each R3 is independently C1-6alkyl, R4 and R5 each is independently hydrogen or C1-6alkyl; or their pharmaceutically acceptable salts, as well as pharmaceutical compositions containing these compounds.
EFFECT: invention can selectively modulate 5-HT receptors, including 5-HT6 and 5-HT2A receptors.
17 cl, 1 tbl, 6 ex
SUBSTANCE: described are new derivatives of 1,2,4-triazole with general formula or , their pharmaceutically acceptable salts, where R1 is H, C1-6alkyl, CONH2 or COOH; R2 is H; R3 is H, halogen or O-C1-4 perfluoroalkyl; R4 is H or halogen; one of the radicals R5, R6, R7 is H; the other is H or halogen, and the third is O-C1-6 alkyl, halogen, O-C0-4alkyl C1-4perfluoroalkyl, O-C2-6alkenyl, phenyl, possibly substituted with 1 to 3 substitutes, chosen from halogen, CN, CF3, pyrazole, -ORa, where Ra is CF3, NRaRb, where Ra and Rb are C1-4alkyl, a group with formula C(O)-ORa, where Ra is C1-4alkyl, or a group with formula - O-C1-4alkylphenyl, where phenyl can be substituted with 1 to 3 halogens; a pharmaceutical composition containing said compounds.
EFFECT: use of new compounds for treating and preventing chronic and neuropathic pain.
39 cl, 72 ex
SUBSTANCE: formula compound is described, where X is oxygen; R1 is a linear or branched C1-C8-alkyl chain, substituted with phenyl, optionally substituted with halogen atoms; R2, R3 independently represent hydrogen, C1-C3-alkyl chain, halogen, methoxy; R4, R5, R6, R7 independently represent hydrogen, as well as a method of obtaining formula (I) compound, and a pharmaceutical composition.
EFFECT: use of the compound to make a medicinal agent which is effective as a modulator of the sodium and/or calcium channel and, consequently, suitable for preventing, relieving and treating a wide range of pathologies which include neurological, psychiatric, cardiovascular, phlogistic, eye, urological, metabolic and intestinal diseases, where the above mentioned mechanisms are described as playing a pathological role.
6 cl, 11 ex
SUBSTANCE: invention refers to pharmacy. A vegetable material that is an elevated part of Panzerina lanata 50%; prairieweed sprouts 25%; cowberry roots 25%, is extracted with 50-60% ethyl alcohol at 55-65 C at the ratio of raw material to extractant 1:(14-16). Said process is performed three times. Extraction time in the 1st and 2nd phase contacts is 60 min, in the 3rd phase contact is 30 min.
EFFECT: invention allows improving product activity.
12 tbl, 3 ex