Method for preparing common valerian alcoholate

FIELD: medicine.

SUBSTANCE: invention refers to chemical-pharmaceutical and medical industry. Common valerian roots and rhizomes are extracted in 70% ethyl alcohol with following filtration of the extract from herbal raw material. Extraction is aided with ultrasonic waves of frequency 30 kHz and intensity 365-370 Wt/cm2 during 18-20 minutes at temperature 25-27°C at the relation of herbal raw material to 70% ethyl alcohol as 1:10.

EFFECT: invention allows improving yield and reducing preparation time of the product.

2 cl, 1 dwg, 1 tbl, 1 ex

 

The invention relates to chemical-pharmaceutical and medical industry, in particular to methods of obtaining funds for the prevention and treatment of nervous diseases.

The use of herbal remedies for the prevention and treatment of various diseases has a high degree of safety with sufficient efficiency, the possibility of a more prolonged usage, which is important for the correction of patients with chronic diseases. Drugs from medicinal plants are recommended not only for patients but also healthy people for prevention of various diseases, improve the body resistance and correction of violations, on the verge of health and disease. Proper selection of medicinal plants in accordance with the individual characteristics of the patient and the specifics of the disease can significantly improve the patient's condition.

In modern medical practice Valerian tincture is prescribed for diseases involving the nervous agitation, insomnia, migraine headaches, hysteria. Especially widely used Valerian in milder forms of neurasthenia, pre - and menopausal disorders, vegetarisch, the neuroses of the cardiovascular system, as well as for prevention and treatment of early stages of angina, hypertension is a disease, in some diseases of the liver and biliary tract, diseases, accompanied by cramps of the stomach and intestines with impaired secretion. Tincture of Valerian reduces the excitability of the Central nervous system and calming effect is slowly but steadily. Patients relieves tension, irritability, and improved sleep.

Despite the considerable range of herbal remedies that have sedative effects, tincture of Valerian, due to its popularity remains the most widely used among them means. The effect of the drug depends on the content of essential oil, much of which is an ester of borneol and isovalerianic acid. The drug facilitates the onset of natural sleep and deepens it. Valeric acid contained in the product, has a weak spasmolytic action. The drug is virtually feelings of fatigue, does not affect mental and physical performance.

Closest to the claimed invention is a method for Valerian drug by extraction of raw materials in 70% ethyl alcohol and subsequent filtration of the extract from the plant material. The extraction was performed at room temperature 20÷22°C for three days. The extraction was taken as the ratio of raw material: the former is Regent 1:10 (by weight). As raw materials use the roots and rhizomes of Valerian. (The state Pharmacopoeia of the USSR).

The disadvantage of this method lies in the fact that to receive infusions need quite a long maceration of raw materials in the extractant is ethanol, which should be performed within 3 days, and incomplete extraction of valuable components.

The objective of the invention is to intensify the process of extraction and reducing costs.

The technical result of this method is the increase in the yield and quality of the target product, as well as the reduction of the process time of receipt of the tincture Valerian.

The task and the specified technical result is achieved by the fact that in the method of obtaining Valerian drug, including extraction of roots and rhizomes of Valerian in 70% ethyl alcohol, filtering the extract from the plant material according to the invention the extraction is performed under the influence of ultrasonic waves with a frequency of 30 kHz and an intensity of 365÷370 watts/cm2the extraction process should be performed within 18÷20 minutes. Ultrasonic treatment is carried out at a temperature of 25÷27°C, while the ratio of vegetable raw materials and 70% ethanol 1:10.

The use of ultrasound with a frequency of 30 kHz can significantly reduce the time required for the teachings of tincture Valerian, and also to increase the yield of valuable components, providing its action. When using ULTRASOUND with a frequency below 30 kHz output of biologically active substances is reduced, the use of ultrasound with a frequency above 30 kHz impractical due to excessive power consumption. Use as a solvent of ethanol is associated with its food and pharmaceutical application.

The use of ultrasound with intensity 365÷370 watts/cm2ensures the achievement of the technical result - improving product yield and reducing the time of its receipt. When using lower intensities of ultrasound exposure time is increased to achieve a technical result, and the increased intensity leads to destruction allocated pectin.

The time of ultrasonic treatment is 18÷20 min and is optimal for maximum output valerianic acid. Reducing the time to achieve the desired output, and the increase in the duration of ultrasonic treatment leads to the destruction of biologically active substances. The invention eliminates a long maceration of plant raw materials and to reduce the time of receipt of Valerian tincture. The implementation of this method allows to reduce time of processing of raw materials, because in this implementation of the method is the need to pre-soak.

Conducting the process at a temperature of 25÷27°C allows to achieve the project objectives, in addition, at a given temperature does not occur inactivation of valerianic acid, which allows you to get a quality product.

The ratio of vegetable raw materials and 70% ethanol 1:10 is the most appropriate because it provides the most complete extraction of valerianic acid from vegetable raw materials.

Determining the authenticity of the extracts obtained by conventional infusion and using ultrasonic extraction was performed according to the Pharmacopoeia. This made the determination of the content of valerianic acid and the dry residue.

The invention is illustrated in the drawing, which depicts the dependence of the content of valerianic acid from the timing and intensity of ultrasonic influence.

The inventive method of obtaining tincture Valerian was carried out as follows. Ultrasonic generator configured according to the intensity, the hanging plant materials were placed in a chemical glass and filled with ethyl alcohol (70%), after which the nozzle of the generator was loaded into a glass and raw materials were subjected to ultrasound. After ultrasonic extraction the plant material was separated by filtration.

Optimal conditions of the experiment were determined based on the content Valerie is a new acid in solution. Too powerful ULTRASONIC or too long exposure time destroy valeric acid, as evidenced by the reduction of its content in the obtained extracts.

Example 1.

Took the hanging roots with rhizomes of Valerian 5 g were placed in a chemical beaker was filled with ethanol (70%) 50 g (1:10). Ultrasonic treatment of the extracts was performed using an instrument IKASONIC U 50 control (30 kHz). The nozzle of the generator of ULTRASONIC waves was immersed in the chemical glass. Ultrasonic effect on the solid plant material was carried out with an intensity 368 watts/cm2within 20 minutes.

After processing is completed, the solution was filtered through a layer of gauze.

Then there was the determination valerianic acid and the dry residue. The temperature of extraction 25°C.

The content of valerianic acid 0,39%.

Example 2.

The experiment was carried out analogously to example 1 except that the ultrasonic treatment was carried out with an intensity of 350 W/cm2within 20 minutes.

The content of valerianic acid of 0.15%.

Therefore, the decrease of intensity of ultrasonic treatment leads to a decrease in the content of valerianic acid.

Example 3.

The experiment was carried out analogously to example 1 except that the ultrasonic treatment was carried out with an intensity of 380 watts/cm2within 20 minutes.

The contents of the shaft is Lanovoy acid 0,11%.

Therefore, increasing the intensity of ultrasonic treatment leads to reduction of the yield of pectin.

Based on these examples we can draw the following conclusions: the optimal conditions of ultrasonic influence is the intensity of 365÷370 watts/cm2and the processing time is 18÷20 minutes.

The table presents the comparison of traditional method and declare under optimal conditions.

Comparing the effectiveness of traditional soaking and ULTRASONIC extraction in obtaining a medical tincture Valerian
IndicatorsTraditional macerationULTRASONIC extraction (under optimal conditions)GFK*
Time extract
3 days20 minutes
The content of valerianic acid, %0,230,39not less than 0,2%
The dry residue, %3,33,5at least 3%
∗)GFK - State Pharmacopoeia

This method will speed up the process of tincture Valerian and reduce the cost of its receipt, to improve the yield and quality of the target product, which is determined by the content of valerianic acid.

This invention is in the stage of laboratory research.

1. The method of obtaining Valerian drug, including extraction of roots and rhizomes of Valerian in 70%ethyl alcohol, filtering the extract from the plant material, characterized in that the extraction is carried out at an additional influence of ultrasonic waves with a frequency of 30 kHz and intensity 365-370 W/cm2the extraction process is carried out in air for 18-20 minutes at a temperature of 25-27°C.

2. The method according to claim 1, characterized in that the ratio of vegetable raw materials and 70%ethanol 1:10.



 

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