Method for normalisation of thrombocyte sensitivity to aggregation inducers in patients suffering from arterial hypertension with impaired glucose tolerance

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology and endocrinology, and concerns normalisation of thrombocyte sensitivity to aggregation inducers in patients suffering from arterial hypertension with impaired glucose tolerance. That is ensured by integrated therapy including graduated physical exercises, and introduction of lisinopril in a dose 10 mg once a day in the morning and pioglitazone in a dose 30 mg once a day in the morning. Therapeutic course lasts for at least 6 weeks. The method enables complete normalisation of thrombocyte sensitivity to aggregation inducers owing to potentiation of therapeutic effect of certain components of integrated therapy.

EFFECT: that in turn allows reducing risk of thrombotic complications in given group of patients.

1 ex, 3 dwg, 2 tbl

 

The invention relates to medicine, namely to Hematology and endocrinology.

Analogues of the proposed method of normalization of the increased sensitivity of platelets to aggregation inducers in patients with arterial hypertension (AH) with impaired glucose tolerance (IGT) does not exist.

In the literature there are recommendations for the purpose of physical training for the correction of metabolism in the elements of the metabolic syndrome (Diamond, VA, Supportive AV, Shlyakhto E.V., Krasilnikova H. Metabolic cardiovascular syndrome. SPb.: Ed. SPb. (MCM). 1999. - 208 S.).

Pioglitazone is used in patients with IGT and diabetes type 2 diabetes to reduce insulin resistance (Demidov T.U. and other Application glitazones in patients with diabetes mellitus type 2 in combination with obesity. // The doctor, 2006, No. 10, website: http://www.lvrach.ru/doctore/2006/10/4534509).

For the correction of high blood pressure in hypertension with IGT used lisinopril.

However, never before medical complex consisting of dosed physical activity, pioglitazone and lisinopril, have not been applied in patients with IGT to normalize available to them increased sensitivity of platelets to the combinations of inductors - diphosphate (ADP) + epinephrine, ADP + collagen, adrenaline + collagen, ADP + adrenaline + collagen, ADP + adrenaline + thrombin, with osobni lead to the development of hyperaggregation and macrothrombocytopenia vessels, determining deterioration of the trophic tissue, the risk of heart attacks and strokes in persons with hypertension and IGT.

The aim of the invention is the normalization of the increased sensitivity of platelets to aggregation inducers in patients with IGT.

The essence of the proposed method lies in the fact that after blood collection, its stabilization by sodium citrate 3.8 percent, the separation of blood into plasma and erythrocytes by centrifugation to obtain platelet-rich plasma (BTP) on slides conduct tests on platelet aggregation with multiple combinations of inductors. Visual assessment of platelet aggregation under these conditions allows a small volume of 0.02 ml) of plasma and a small amount of the inductors assess the sensitivity of platelets to aggregation inducers on the development of the aggregation process. With increasing their sensitivity to inducers registered on reducing the need for aggregation dose of the inducer in the application of double and triple combinations, possible to perform correction by assigning at least 6 weeks dosed physical activity and drugs pioglitazone 30 mg 1 time a day, morning and lisinopril 10 mg 1 time per day in the morning.

The inventive method is carried out as follows. After taking the patient 9 ml of blood in sodium citrate 3.8% in the ratio of 9:1 her centrifuged for 5 min at 1000 rpm, for p the receipt of BTP. Part of the plasma is taken, and the remainder centrifuged at 3000 rpm for 20 min, receiving platelet-poor plasma (Betp). BTP standardise the number of platelets by dilution of the original BTP autologous sample Betp (up to 200·109/HP).

The standardized volume of plasma is withdrawn from the calculation of 0.02 ml of plasma for each inductor and investigated the combination of inductors. The remaining volume of plasma can be used for other hematological and biochemical investigations.

Selected standardized volume of plasma on a glass slide cause of 0.02 ml of plasma and different pipette solutions of two or three inductors (Fig 1 and 2) with a total volume equal to the volume of plasma. When using one inductor volume is 0.02 ml, when using two of 0.01 ml, three on 0,007 ml.

As agonists can be used ADP, collagen, thrombin, epinephrine in combination ADP + epinephrine, ADP + collagen, adrenaline + collagen, ADP + adrenaline + collagen, ADP + adrenaline + thrombin required dose which in this case were lower than for stand-alone usage, and for any triple combination of inductors is even lower. Dose inductors required for aggregation in patients with hypertension and IGT, and minimum vzaimootmenyaemye dose inductors have lower than standard (table 1 and 2), is able to cause the ü platelet aggregation in healthy people. Glass wand mix plasma with inductors and include a stopwatch. The mixture is stirred so that the liquid held a circle with a diameter of about 2 cm (figure 3). Shaking the glass in a circular motion in transmitted light illuminator on a black background is watched through a magnifying glass for the occurrence of aggregates. With the appearance of distinct units, the enlightenment of the solution and the adhesion of some units to the glass stopwatch off, fixing the time of platelet aggregation.

From the material presented, it follows that in comparison with the stimulation of one inductor in healthy people when using in patients with hypertension and IGT and especially two and three inductors require a much smaller concentration of agonists for the development aggregation that is probably due to the involvement of multiple mechanisms of activation. It should be noted that the study of the aggregation ability of blood platelets with two and three inductors to simulate events that occur in blood flow in the damaged area of the vessel and the initiation of the process of hemostasis. Thus, in patients with hypertension and IGT was found regularities expressed more than healthy people because of the increased sensitivity of platelets to aggregation inducers with a lower concentration of inductors required for the development of the aggregation of blood platelets.

Table 1
The standard dose of inductors, causing platelet aggregation when they are a stand-alone application.
InductorsADP, MAdrenaline, MCollagen, the main breeding suspensionThrombin, a unit/ml
Dose0,5·10-45·10-61:20,125

Table 2
Minimum article concludes that concentrations of inducers aggregation in healthy individuals and patients with arterial hypertension with impaired glucose tolerance in dual and triple combination.
Category surveyedCombinations of inducers of platelet aggregation
ADP, MAdrenaline, MCollagen, the main breeding suspensionThrombin, a unit/ml
with the same agonistWith two agonistswith the same agonistwith two agonistsonewith twowith the same agonistwith two
Healthy people, n=2110-65·10-72,5·10-710-71:41:50,1000,090
Sick people, n=10710-75·10-85,0·10-85·10-81:71:80,0800,070

From tables 1 and 2 it follows that the minimum causing aggregation dose of inductors, with the combined use of them is significantly lower than in standard conditions when using effects on platelets of the same agonist. At simultaneous presence in BTP three inductors, the dose required for aggregation, even lower than in the case of two inductors. And Bo is lnyh arterial hypertension with impaired glucose tolerance, these values are even lower, that says they expressed the activation of platelets. Simultaneous use of multiple inductors brings our understanding of the required minimum concentration of inducers in real conditions at the initiation of hemostasis in blood vessels of a person.

To diagnose an increased sensitivity to inducers aggregation in patients with IGT possible with the development of platelet aggregation when using isolated inductors at doses below those specified in table 1, and in their double and triple combination is listed below in table 2 for healthy people. In patients with IGT typical concentrations are given in table 2.

When the detection sensitivity of platelets to aggregation inducers sick AG with IGT are appointed for 6 weeks dosed physical load and drugs pioglitazone 30 mg 1 time a day, morning and lisinopril 10 mg 1 time per day in the morning.

The inventive method is carried out as follows.

The first component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics, after whom the duty to regulate to do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increased activity, improved health and performance.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG with IGT recommended treatment and preventive exercises. Depending on the initial fitness in which you can use at the start of a lightweight variant of physical activity, and later reinforced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with IGT.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve the Roux is in hand with turning the palms up - the breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands free. The walk free -1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen in./p>

Exercise 13. Standing, feet together, hands pubescent. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. A quiet walk with a uniform average depth of breathing. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor: (a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (C) self-massage of the abdomen small polukrugom movements clockwise - 1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. Retraction of the stomach is to be combined with the exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking quiet breathing average depth of 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large trowel napryazheniem, and delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving.

For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left, bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction pauperem the NGOs. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on the waist bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Sick AG with IGT is patient with disorders of the cardiovascular system. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why increasing the physical activity of persons suffering from hypertension with IGT should be implemented by the distribution of physical activity in small doses throughout the day. This method of increasing physical activity in patients with hypertension with IGT should be considered as a method of fractional loads.

Depending on the conditions of real life AH patients with IGT can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

The second component of the proposed method - the purpose of pioglitazone 30 mg 1 time per day in the morning. The third component is lisinopril 10 mg 1 time per day in the morning.

The method allows to normalize the sensitivity of platelets to aggregation inducers in patients with the TG within 6 weeks of treatment, bringing it to the level characteristic of healthy persons subject in the following these recommendations it is possible to eliminate the increased sensitivity of platelets in persons with hypertension and IGT to the inductors aggregation that will significantly reduce their risk of thrombotic complications, strokes and heart attacks.

Example. Patient S., 49 years old, with hypertension and impaired glucose tolerance, in the dispensary of hypertension in the clinic at the place of residence examined routinely.

Platelet aggregation was assessed in patients with combinations of inductors: ADP + epinephrine, ADP + collagen, adrenaline + collagen, ADP + collagen + epinephrine, ADP + adrenaline + thrombin. Minimum article concludes that aggregate concentration in the case of two inductors accounted for ADF - 10-7M, collagen - 1:7 dilution of the primary suspension of collagen, adrenaline - 5,0·10-8M, thrombin - 0,080 units/ml. In the case of the simultaneous use of three inductors their minimum concentration was lower. For ADP - 5,0·10-8M, for collagen - 1:8 dilution of the primary suspension, adrenaline - 5,0·10-8M, thrombin - 0,070 units/ml.

Development of platelet aggregation with minimal vzaimopodderzhivayuschimi doses of inductors indicates a violation (activation) aggregation of platelets.

The patient was assigned adequate hypotensive therapy lisinopril 10 mg 1 time a day, dosed physical load and pioglitazone 30 mg 1 time per day in the morning. This allowed after 1.5 months. treatment to cause minimal vzaimootmenyaemye dose inductors, causing platelet activation, to the level of healthy people. Minimum article concludes that aggregate concentration in the case of two inductors accounted for ADF - 10-6M, collagen - 1:4 dilution of the primary suspension of collagen, epinephrine is 2.5·10-7M, thrombin - 0,100 units/ml. In the case of the simultaneous use of three inductors their minimum concentration was lower. For ADF - 5·10-7M, for collagen - 1:5 dilution of the primary suspension, adrenaline - 10-7M, thrombin - 0,090 units/ml.

Thus, activation of platelets in response only to vzaimootmenyaemye dose inductors typical of healthy humans suggest that the normal function of platelets in patients.

The patient was recommended to continue to comply with these recommendations.

Way to normalize the sensitivity of platelets to aggregation inducers in hypertensive patients with impaired glucose tolerance, including the assignment for at least 6 weeks dosed physical activity, lisinopril 10 mg 1 time a day, morning and PIO is glitazone 30 mg 1 time per day in the morning.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns normalisation of antiplasmin alpha-2 level in arterial hypertension (AH) with impaired glucose tolerance. That is ensured by complex treatment involving graduated physical activities, and introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning within 1.5 months.

EFFECT: such complex of specific pharmacological preparations combined with drug-free modalities, as well as fitted duration of treatment provide reduced risk of thrombotic complications that is ensured by normalisation and correction of antiplasmin alpha-2 level, thereby fibrinolytic systems in the given group of patients.

3 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns normalising endotheliocytemia in arterial hypertension with impaired glucose tolerance. It is ensured by complex therapy that involves graduated physical activities, as well as introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning during 1.5 months.

EFFECT: invention provides effective correction of endotheliocytemia owing to potentiation of therapeutic effect of certain components of the complex therapy; than in turn allows reducing risk of thrombotic complications in the given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology, and covers hyperfibrinogenemia correction in arterial hypertension with impaired glucose tolerance. It is ensured by complex treatment that involves graduated physical activities, as well as introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning during 1.5 months.

EFFECT: invention provides effective correction of fibrinogen level that is ensured by potentiation of therapeutic effect of certain components of complex therapy; than in turn allows reducing risk of thrombotic complications in the given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely to haematology, cardiology and endocrinology, and covers normalising the level of inhibitor of plasminogen activator in arterial hypertension (AH) with impaired glucose tolerance. It is ensured by complex treatment that involves graduated physical activities, as well as introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril 10 mg once a day in the morning.

EFFECT: invention provides normalising the level of inhibitor of plasminogen activator that resulted from 1,5-month therapeutic course; than in turn allows reducing risk of thrombotic complications in the given group of patients.

1 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology, and covers correction of blood microvesicle level in arterial hypertension, dyslipidemia and impaired glucose tolerance. It is ensured by complex treatment that involves introduction of fozinopril in a dose 10 mg once a day in the morning, pioglitazone in a dose 30 mg once a day in the morning, simvastatin in a dose 40 mg in the evening in combination with graduated physical activities for therapeutic course at least 6 weeks.

EFFECT: invention provides complete normalisation of blood microvesicle level ensured by potentiation of therapeutic effect of certain components of the complex therapy; that in turn allows reducing risk of thrombotic in the given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to endocrinology, and can be used for treating type 2 diabetes that is ensured by introduction of effective amount of compound Cysteamine or its salts combined with metformin or insulin.

EFFECT: invention allows improving clinical effectiveness due to higher expression of glucose transporter and higher adiponectin level that increases insulin sensitivity.

7 tbl, 4 ex, 10 dwg

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology, and covers correction of thrombocyte intravascular activity in patients suffering from arterial hypertension with impaired glucose tolerance. It is ensured by integrated treatment including graduated static and dynamic loading, and introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning.

EFFECT: such complex of specific medical agents and physical activity provides short-term - within 1,5 months - normalisation of thrombocyte intravascular activity that in turn reduces risk of thrombotic complications in given group of patients.

1 ex

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