Method for thrombocyte normalisation of adenosine diphosphate and adenosine triphosphate in patients with arterial hypertension and impaired glucose tolerance

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, and covers thrombocyte normalisation of ADP and ATP secretion in patients with arterial hypertension and impaired glucose tolerance. It is ensured by integrated treatment including graduated physical exercise, introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning.

EFFECT: such complex of specific pharmacological preparations and drug-free modalities provide complete thrombocyte normalisation of ADP and ATP secretion within 1,5 months that in turn allows normalising thrombocyte function in this group of patients.

1 ex

 

The invention relates to medicine, namely to Hematology.

Analogues of the proposed method to normalize the secretion of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) from platelets in patients with arterial hypertension (AH) with impaired glucose tolerance (IGT) does not exist.

In the literature there are recommendations for the purpose of physical training for the correction of metabolism in the elements of the metabolic syndrome (Diamond, VA, Supportive AV, Shlyakhto E.V., Krasilnikova H. Metabolic cardiovascular syndrome. SPb.: Ed. SPb. (MCM). 1999. - 208 S.).

For the correction of insulin resistance in hypertension with IGT can be used pioglitazone.

As antihypertensives in patients with IGT applied lisinopril. However, never before medical complex, consisting of physical exertion, pioglitazone and lisinopril was not used to normalize the secretion of ATP and ADP from platelets.

The aim of the invention is to devise a method to normalize the secretion of ADP and ATP from platelets in patients with IGT.

The essence of the proposed method lies in the fact that in order to normalize the secretion of ADP and ATP from platelets in patients with IGT is assigned a complex of the dosed physical activity and drugs lisinopril and pioglitazone.

The method is to follow the way. To determine the content in platelets of ATP and ADP and the size of their secretion under the influence of collagen used method of thin-layer chromatography on plates Silufol, allowing to evaluate the ultrastructural characteristics of intact platelets and character micromalting interaction at the main stages of development of the hemostatic process (Ermolaeva T.A., Golovin OG, Ponomarenko V. M. et al. // The laboratory. business, 1993. No. 6. - p.45-53) followed by spectrophotometry soluble eluates at a wavelength of 257 nm. The method is a direct biochemical method for assessing the effectiveness of the process of secretion of platelets by the difference in the content of ATP and ADP in platelets before and after secretion, expressed in % of the initial content in the cells.

1. At the bottom of the chromatographic banks pour the solvent for 2-3 hours before placing them in the plates and quickly and tightly closed glass jar brushed surface down. The composition of the solvent: 1:4 dioxane, isopropanol, 25% ammonia, distilled water in the ratio 4:2:1:4 (1 liter - 44 ml of solvent, 1.5 l - 66 ml).

2. Bred uterine suspension of collagen Michaelis buffer to a certain functional of the concentration giving 50%drop in optical density in the study of collagen platelet aggregation in the group of healthy persons.

3. Prepare plate Silof the l size: length - 13.5 mm, width - 7.5 see

4. For studies take blood from the cubital vein of the person to 22.0 ml, stabilize the sodium citrate in the ratio of 4:1. Get the plasma rich in platelets (centrifuged 10 min at 1000 rpm). Such plasma to platelets 250-300×109a quart.

2 silikonizirovannaya centrifuge tube add 5 ml of platelet plasma sample, the material for level measurement Denisovich nucleotides prior to secretion (first tube) and after secretion (II tube). The 1st of them (control) type of 0.55 ml of solution pH 7.4 and 0.3 ml of 1% ethylene-diamine-tetraoxane acid (EDTA), rn,4. The 2nd tube (experience), placed in a water bath at 37°C, add 0,55 ml suspension of collagen and produce rapid mixing with a glass rod for 10 minutes the Reaction platelet secretion is stopped by the addition of 0.3 ml of 1% EDTA, pH 7.4.

Further manipulation of the material in the 1st and 2nd vitro spend the same.

- Receive precipitate platelets by centrifugation at 4000 rpm × 20 min.

- Spend 2-fold laundering precipitate from plasma proteins buffer Phillips.

The deproteinization is carried out by precipitation of platelets to 0.04 ml of 6% perchloric acid and stirring with a glass rod for 10 minutes in the tub with ice.

- Centrifuged at 4000 rpm × 10 minutes at 0°C.

- Setting nadeshiko n is sicom dispenser 0.02 ml appendrows microtube, immersed in an ice bath.

- Neutralization of material in ice (about 0.01 ml) is added 2 M K2CO3when mixing glass capillary for 8 minutes under the control of the filter paper to a pH of 7-8.

- Deposition of the precipitate formed in appendrows tubes, closed the lid, when Ob/min × 30 seconds.

- Trying to enter adosados in the noses of dispensers, which are placed in a horizontal position in the racks.

- Material of the control and experimental systems put on the starting line 2 plates, spaced 2 cm from one side.

- Dried by a stream of cold air and put vertically in a jar for chromatography so that the plates do not touch each other.

When the solvent front at 0.5 cm will not reach the upper edge of the plate, gently wash, dried by a stream of cold air and looking at chromoscope under ultraviolet light. If traced 2 or 3 black spots, parallel to the starting line, i.e. it took a good separation Denisovich nucleides, spot ATP (1st from the start) and ADP (2nd from start) easily lead round a pencil and scratch out their putting into centrifuge tubes. Scrapings pour 3 ml of 0.1 m Hcl at night, during which the extraction of acid-soluble Denisovich nucleides.

After 24 hours the material centrifugated is 20 minutes at 1500 rpm acid-soluble eluate containing aderinoye nucleotide, transferred to clean tubes and spectrophotometrically vs. control (0.1 M HCl) at 257 nm.

Normal value content of ATP and ADP to secretion in platelets are 5.3-5.9 mmol/1011Tr. and 3.5 to 3.8 mmol/1011Tr. accordingly, the normal secretion of ATP and ADP from platelets is 33-36% and 39-46%, respectively.

When establishing enhance the secretion of ADP and ATP from platelets in patients with IGT is assigned a method of correction for 1.5 months.

The method is performed in the following way.

The first component of the proposed method is feasible regular physical exercise.

In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging); 2) health care gymnastics; 3) fractional exercise during the day.

1. Morning hygienic gymnastics (charging).

Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.

The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercise issue is Lauda with gradually increasing excursion of breath, tensile, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).

In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.

When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.

After gymnastics, you must go to the rubbing or take a shower.

Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.

If you feel unwell, develop shortness of breath or pain in the heart and behind the sternum should be temporarily suspend classes and consult a doctor.

During the day, sick AG with IGT recommended treatment and preventive exercises. Depending on the initial fitness may use first lightweight option, physical activity, and subsequently enhanced option.

2. Complexes of preventive and curative gymnastics for persons suffering from hypertension with IGT.

2.1. The lightweight version of preventive and curative gymnastics.

Exercise 1. Standing. A quiet walk with a gradual acceleration and what amelanism 1-2 minutes During exercise the gradual deepening of the breath.

Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.

Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.

Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.

Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead leg. 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.

Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.

Exercise 7. Standing, hands is free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.

Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.

Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.

Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.

Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.

Exercise 12. Standing, feet together, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.

Exercise 13. Standing, feet together, hands down. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.

Exercise 14. Standing. The walk is quiet with a uniform water is the use of average depth. 1-2 minutes

Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.

Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.

Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; g) to go into a standing position, and son-in-law in the supine position; d) self-massage of the abdomen small polukrugom movements clockwise-1-2 minutes Rest 2 min; (e) the quiet breath; g) exercise in the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.

Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.

Exercise 19. Sitting on a chair, legs apart, hands the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.

Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes

When the source sufficient trained or arising in the course of the practice of tolerance to physical loads, you can use the following set of exercises.

2.2. Enhanced preventive and curative gymnastics.

Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes

Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.

Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.

Exercise 4. Standing, feet shoulder-width apart, hands pubescent. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.

Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 to 10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.

Exercise 6. The quiet walk 1-2 minutes

Exercise 7. Led is on the edge of the chair, hands on waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.

Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.

Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath by 4-6 times.

Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes

Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. Standing, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage, and the delay in the stress state within 2-3 C.

Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes

Exercise 13. C is I on the edge of the chair, straight legs divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.

Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes

Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.

Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.

Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.

Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.

Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation of the pelvis to the left to bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.

Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times./p>

Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.

Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes

Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.

Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.

Exercise 25. Standing, feet apart at shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.

Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.

Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath, with flattening and pulling stink the belly - exhalation. Breathing deep.

Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes

3. Fractional exercise during the day.

Sick AG with IGT is patient with impaired cardiovascular systems. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why increasing the physical activity of persons suffering from hypertension with IGT should be implemented by the distribution of physical activity in small doses throughout the day. This method of increasing physical activity in patients with hypertension with IGT should be considered as a method of fractional loads.

Depending on the conditions of real life AH patients with IGT can recommend various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.

Option 1.

Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.

Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.

Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.

Option 2.

Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.

Uprajnenie is 2. Standing - circular head movements to the right and left - 3-8 times in each direction.

Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.

Exercise 4. Sitting - transition into the standing - 10-12 times.

Option 3.

Exercise 1. The quiet walk - 1 min

Exercise 2. Walking fast - 1 minute

Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.

Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room - 2-5 minutes

Option 4.

Walk the pedestrian varying length.

Option 5.

Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).

In addition to the individually selected physical exercises sick AG with IGT are prescribed drugs pioglitazone 30 mg 1 time a day, morning and lisinopril 10 mg 1 time per day in the morning. The method is able to normalize lipid peroxidation and platelet hemostasis. This is the basis of inhibition of atherosclerosis, effective prevention of vascular complications, improve quality and extend the life of AH patients with IGT.

The method allows to normalize the secretion of ATP and ADP in patients with IGT, which largely improves their is gregario for 1.5 months bringing it to the level characteristic of healthy people. Subject in the following these recommendations, the possibility of increased secretion of ATP and ADP from platelets in patients with IGT is excluded.

The implementation of this method to normalize the secretion of ADP and ATP in platelets in patients with IGT will allow you to solve a number of pressing socio-economic problems. Timely and adequate use of effective in each case the treatment method of thrombocytopathy in patients with IGT will allow for timely korrigirovat thrombophilia, be reduced in these patients, the period of temporary disability, prevent strokes and heart attacks by reducing the number of outputs on disability and reducing mortality among this contingent of patients.

Example. Patient M (54 years old)suffering from hypertension with IGT during the 6 years examined routinely. The patient was taken and examined the blood with the assessment of the storage pool of ATP 5.4 mmol/1011Tr. and ADP - 3.7 mmol/1011Tr. and with the secretion of 40.0% to 57.0%, respectively. The results indicated normal levels in the platelet ADP and ATP and increased secretion by platelets of the patient.

The patient is assigned a complex of dosed physical activity, pioglitazone 30 mg 1 time per day in the morning and lisinopril 10 mn 1 time per day in the morning. This is the allowed 1.5 months to normalize the secretion of platelet - ATP to 34.0% and ADP to 41,0%.

Compliance in the future, these recommendations would eliminate the increased secretion of ADP and ATP in platelets of the patient.

Method normalize the secretion of ADP and ATP in platelets in patients with arterial hypertension with impaired glucose tolerance, including dosed physical load, introduction of pioglitazone 30 mg 1 time per day in the morning and lisinopril 10 mg 1 time per day in the morning.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely to haematology, cardiology and endocrinology, and covers normalising the level of inhibitor of plasminogen activator in arterial hypertension (AH) with impaired glucose tolerance. It is ensured by complex treatment that involves graduated physical activities, as well as introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril 10 mg once a day in the morning.

EFFECT: invention provides normalising the level of inhibitor of plasminogen activator that resulted from 1,5-month therapeutic course; than in turn allows reducing risk of thrombotic complications in the given group of patients.

1 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely haematology, cardiology and endocrinology, and covers correction of blood microvesicle level in arterial hypertension, dyslipidemia and impaired glucose tolerance. It is ensured by complex treatment that involves introduction of fozinopril in a dose 10 mg once a day in the morning, pioglitazone in a dose 30 mg once a day in the morning, simvastatin in a dose 40 mg in the evening in combination with graduated physical activities for therapeutic course at least 6 weeks.

EFFECT: invention provides complete normalisation of blood microvesicle level ensured by potentiation of therapeutic effect of certain components of the complex therapy; that in turn allows reducing risk of thrombotic in the given group of patients.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to endocrinology, and can be used for treating type 2 diabetes that is ensured by introduction of effective amount of compound Cysteamine or its salts combined with metformin or insulin.

EFFECT: invention allows improving clinical effectiveness due to higher expression of glucose transporter and higher adiponectin level that increases insulin sensitivity.

7 tbl, 4 ex, 10 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, more specifically to endocrinology, cardiology and rheumatology and correction of metabolic syndrome in patients with deforming ostheoarthrosis. For this purpose in addition to traditional therapy with non-steroidal anti-inflammatory drugs and antihypertensive therapy agents, arthrofoon is sublingually administered 1 tablet four times a day, together with siofor in a dose of 500 mg 2 times a day for 12 months.

EFFECT: effective correction of metabolic and articular disorders due to synergetic effect of arthrofoon and siofor, taken in the given doses and regimes.

7 tbl

FIELD: chemistry; medicine.

SUBSTANCE: invention can be used in production of preparations for treatment of pre-diabetic states, type 2 diabetes and glucose tolerance disturbances. Novel peptides, demonstrating properties of selective receptor VPAC2 agonists, in particular ability to stimulate insulin synthesis and its release from β-cells of pancreas by glucose-depending method, as well as following reduction of glucose level in plasma.

EFFECT: increased efficiency of action and stability in comparison with natural peptides, possibility of their successful application in treatment of diseases.

14 cl, 18 dwg, 1 tbl, 10 ex

FIELD: chemistry.

SUBSTANCE: invention concerns novel compounds of the formula (I): , where R1 is -COOH or -(CH2)n-R14; R2 is or , where X is -CH or -N; each of R3, R4, R5 and R6 is selected out of group including -H, -(lower) alkyl, -N(CH3)2, -O-(lower) alkene, -(lower) alcoxy, or where R5 and R6 are substitutes in adjoining carbon atoms in ring, R5 and R6 optionally form 5- or 6-member saturated carbocyclic ring together with adjoining carbon atoms, R14 is unsaturated 5-member substituted or non-substituted heterocyclic ring including 1 to 4 heteroatoms selected out of N, O and S, n is 0 or 1, or their pharmaceutically acceptable salts or complex ethers. Invention also concerns pharmaceutical composition.

EFFECT: obtaining new bioactive compounds and pharmaceutical composition based on them, with inhibition effect on glutamine fructose-6-phosphate amidotransferase (GFAT).

16 cl, 16 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental surgery and concerns prevention of post-resection hyperglycaemia after pancreatectomy in experiment. For this purpose 96 hours before pancreatectomy suspension containing twenty-four-hour culture of pancreatic island cells of newborn piglets in concentration 2×106 in 1 ml of medium is introduced into iliac region once.

EFFECT: method ensures complete insulin-independence of experimental animal after pancreatectomy due to selection of optimal number of introduced cells as well as time and place of their introduction.

1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, cardiology and endocrinology, and concerns normalising endotheliocytemia in arterial hypertension with impaired glucose tolerance. It is ensured by complex therapy that involves graduated physical activities, as well as introduction of pioglitazone in a dose 30 mg once a day in the morning and lisinopril in a dose 10 mg once a day in the morning during 1.5 months.

EFFECT: invention provides effective correction of endotheliocytemia owing to potentiation of therapeutic effect of certain components of the complex therapy; than in turn allows reducing risk of thrombotic complications in the given group of patients.

1 ex

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