Production method of hepatoprotective agent from aspen wood

FIELD: wood working industry.

SUBSTANCE: invention relates to wood chemical industry. Waste wood of aspen is chopped till particle size is less than 1 mm, is dried on air till moisture content is not more than 18%, raw material is watered at a temperature of 18-25°C with the following ratio of the raw material: extractant = 1:1.5-2.5, within 10-24 hours, further mechanical pressing of extractant and concentrating it in a vacuum at a temperature of not higher than 40°C till content of total solids is from 3.5 to 100%.

EFFECT: invention allows fulfilling the specified purpose.

10 ex, 3 tbl

 

The invention relates to chemical industry and the receipt of waste wood aspen funds have hepatoprotective activity, which may find application in chemical, pharmaceutical and food industry.

As hepatoprotectors widely used herbal preparations flavonoid structures in which the active agent is Silimarin, isolated from extracts, milk Thistle fruit. Based on these compounds has developed a number of medicinal drugs "silymarin", "zelibor", "silibinin", "Kars", etc. All these products of foreign manufacture, it is obvious that the relevance and necessity of the search for and study of new natural sources of raw materials.

A method of obtaining funds have hepatoprotective activity, which is dried and ground to a particle size of 1-3 mm raw rhizomes and roots meadowsweet castelpetroso extracted with hot distilled water (90-95°C) at a ratio of raw material:solvent 1:10-15 for 30 min, the extract obtained is separated by filtration, evaporated to 1/3-1/5 of the volume, and cleaning is performed by cooling one stripped off concentrate, deposition from him the target product by adding three volumes of 96%ethanol, by settling, filtering the precipitate, washing sequentially 96%namatakula and ether, followed by separation of the extract (EN 2259208, IPC AC 35/78, publ. 27.08.2005).

The disadvantages of this method include thermal processing of vegetable raw materials, and the selection of the desired product ethyl alcohol. Furthermore, the method requires large power consumption for heating of the extractant and evaporation.

A method of obtaining medicines that have choleretic effect by 5-fold repercolation aspen bark 70%ethanol at room temperature with maceration for 8 hours, followed by removal of the solvent under vacuum at 50°C and bring to a dry extract in a vacuum drying Cabinet at 40°C (EN 2126687, IPC AC 35/78, publ. 27.02.1999).

In a known method is used as raw material the bark of aspen, while the main part of the biomass of aspen wood remains neutiliziruemoy. The disadvantages of the method include the use of alcohol.

A method of obtaining funds with anti opisthorchosis action, from the bark of aspen, which is crushed to a size less than 1 mm raw material is extracted with water at 70°C mixing ratio of raw materials:water of from 1:8 to 1:10, infused over 4-6 hours, drained, defend extract within 2-4 h, concentrated in vacuo at 30-50°C to 60 wt.%, then the rest of the crust is additionally extracted with 45% ethyl alcohol in a ratio of components 1:1 in ECENA 4-6 h, press, combine the water and alcoholic extracts, followed by evaporation and drying in vacuum (EN 2162701, IPC AC 35/78, OR 1/16; 1/18; 33/10, publ. 10.02.2001).

In a known way anti opisthorchosis means separated from aspen bark, and stem part of aspen wood remains in the dump. The disadvantages of the method include extraction with hot water (70°C), which degrades the quality of biologically active substances, since the temperature of 60°C and above destroys vitamins and enzymes. In addition, the disadvantages include the high consumption of electricity.

The closest technology to obtain the claimed invention is a method of obtaining a feed additive for young pigs, which is pressed in a screw feeder shredded aspen wood with obtaining cell SAP (EN 2084177, publ. 20.07.1997)

In this way to obtain a feed additive, which is a cell juice, use a stem portion of aspen wood. However, the disadvantages of this method include low yield of the target product, as well as the seasonality of raw materials.

The technical result of the invention:

1. Expanding Arsenal of ways to get funds from vegetable raw materials with pronounced hepatoprotective activity.

2. The utilization of aspen wood.

Technical results of the t of the invention is achieved by in the method of obtaining hepatoprotective funds from aspen wood, including the grinding of raw materials and its mechanical centrifuge, according to the invention is used as raw material waste aspen wood, which is crushed to a particle size less than 1 mm, then the previously air-dried to a moisture content of not more than 18%, soaked in water at a temperature of 18-25°C. when the ratio of raw material:solvent =1:1.5 to 2.5 with 10 to 24 hours, followed by extraction of the extract and concentrated it in vacuum at a temperature not exceeding 40°C. until the solids content of the product from 3.5 to 100%.

Unlike the prototype in the present method the raw material is a waste of aspen wood (wood chips, twigs, sawdust), and both fresh and stale, which allows to solve the problem of disposal of low and substandard aspen wood. Unlike the prototype, where the wood just mechanically squeezed to obtain the cell SAP, in the invention it is extracted with water. To improve the efficiency of extraction of wood waste aspen additionally crushed to particle size of less than 1 mm, then air-dried to a moisture content of not more than 18%, which allows to preserve the biologically active substances in the native form. Next, the prepared raw material is soaked in water at room temperature from 10 to 24 hours when the ratio of raw material:solvent=1:1.5 to 2.5.

Water fills parenchymal cells, most of which are blank, forming reservoirs between which are designated with nutrients. Next, timber press in the screw feeder, and since water is incompressible, it is with high speed goes, pushing nutrients from the interstitial space and cells broken through the membrane. The pressed liquid contains substances not only in the phloem and cortex, which is the product of photosynthesis, but also those substances which go on the trunk to power the stem portion and provided with more trace elements.

The chemical composition of the squeezed liquid: water - 96,5%; protein - 0,1%; ash - 0,15%; NFE (nitrogen-free extractives) - 2.17%, and sugar - 1,92%; vitamin E - 35,83 mg/l; vitamin C - 32.1 mg/l; CA - 200 mg/l; P -30,0 mg/l; K - 324,0 mg/l; Na - 24,0 mg/l; Mg - 30,8 mg/l; Fe - 11.4 mg/l; Mn - 0.9 mg/l; si 0.1 mg/l; Zn - 0.45 mg/L.

In addition, the pressed liquid contains oleic, linoleic, linolenic, arachidonic acid; vitamins a, To; phosphatidylcholine, phosphatidylethanolamine, galactosialidosis, sterols and their esters, i.e. represents a complex of biologically active substances.

Unlike the prototype wrung liquid concentrate under vacuum at 40°C until the dry matter content of from 3.5 to 100%. Concentrate of biologically active substances (BAS) with the contents dry in the substance of 3.5% - this solution greenish color with a bitter-sour taste and a pleasant characteristic odor, ready-to-eat product. Powdered concentrate of biologically active substances has a reddish-brown color and a bitter taste, easily stored and transported. Possible staging options.

The proposed method is confirmed by specific examples.

Example 1. Waste aspen wood (twigs, wood chips, sawdust) is crushed to a particle size less than 1 mm and dried in air to air dry (moisture - 18%). Then the raw material is soaked in water at the ratio of the volume of timber to the volume of water equal to 1:1 at room temperature for 20 hours. The resulting mass with a humidity of about 65-70% of the press in the screw feeder. Liquid concentrate under vacuum at 40°C until the solids content of the product 3.5%. The yield of liquid concentrate BAS was 15% by weight of dry raw material.

Example 2. The proposed method was implemented analogously to example 1, but the ratio of raw material to the volume of water was equal to 1.5. The yield of the target product is 18%. The results are presented in table 1.

Table 1
The effect of preparation conditions of the biologically active substance concentrate on its output
the
№№ p/pThe volumetric ratio of raw materials:waterThe duration of extraction, hThe yield of the target product, wt.% to ASDThe solids content in the concentrate of biologically active substances, wt.%
1.1,02015,03,5
2.1,52018,03,5
3.2,02018,53,5
4.2,52018,53,5
5.3,020of 17.03,5
6.2,01016,03,5
7.2,012 18,53,5
8.2,02019,03,5
9.2,02419,03,5
102,0200,65100
*and absolutely dry wood

Example 3. The proposed method was implemented analogously to example 1, but the ratio of raw material to the volume of water was equal to 2.0. The yield of the target product to 18.5% (see table 1).

Example 4. The proposed method was implemented analogously to example 1, but the ratio of raw material to the volume of water was equal to 2.5. The yield of the target product to 18.5%.

Example 5. The proposed method was implemented analogously to example 1, but the ratio of raw material to the volume of water was equal to 3.0. The yield of the target product is 17%.

Examples 1-5 can confirm that the optimum ratio of water volume to the volume of aspen wood is 1.5 to 2.5. With a smaller amount of water decreases the output hepatoprotective tools (example 1). With a larger amount of water the amount of recovered product is not significantly changed (example 5), but you want to vaporize a greater amount of ballast water that is not economically profitable.

Example 6. The proposed method was implemented analogously to example 3, but the duration of the extraction of waste wood of aspen water was 10 hours. The yield of the target product is 16%. The results are presented in table 1.

Example 7. The proposed method is implemented analogously to example 3, but the duration of the extraction of waste wood of aspen water was 12 hours. The yield of the target product was 18.5%.

Example 8. The proposed method is implemented analogously to example 3, but the duration of the extraction of waste wood of aspen water was 20 hours. The yield of the target product is 19%.

Example 9. The proposed method was implemented analogously to example 3, but the duration of the extraction of waste wood of aspen water was 24 hours. The yield of the target product is 19%.

Example 10. The proposed method was implemented analogously to example 3, but after pressing the resulting biologically active substance concentrate was dried to a powder. The yield of dry hepatoprotective tools - 0,65% of absolutely dry wood (ASD)

Examples 6-9 illustrate the fact that the optimum duration of extraction water aspen wood is 10-24 hours, because shorter processing snige the Xia yield of the target product, and the long duration of treatment does not give a positive effect, but increases the duration of the process that is economically feasible.

Study of biological activity of the concentrate BAS.

Experimental investigation of hepatoprotective activity of concentrate BAS held on 25 white laboratory mice weighing 41-42, Was formed 5 groups of mice (control and 4 experimental) on the principle of analogues. Feeding the animals ad libitum with free access to water. Cases case no. When conducting a postmortem examination of the internal organs is not observed pathological changes (see table 2).

Animals of control group received the basic diet, and the animals of the experimental groups received in addition to the basic ration from 0.5 to 2.0 ml/bird per day of concentrate BAS (containing 3.5% of dry matter). Parenchymatous organs (liver, kidneys) were investigated as a whole, nadeeka connective tissue capsule body. After weighing electronic scales liver and kidneys were placed in formalin for fixation. The histochemistry of fats and lipids was performed according to the method of Identification of neutral fats Sudan III (Eliseev V.G. and other Basics of histology and histological techniques. - M.: Medicine. 1967).

Table 2
Weight of internal organs is s mice
GroupThe number of animals, goalDose BAS ml/bird per dayMass, g
liverthe left kidneyright kidney
Control5-2,4±0,050,273±0,014to 0.263±0,00
I experienced50,52,199±0,00880,303±0,0020,324±0,002
II experimental51,02,098±0,00350,230±0,010,243±0,0028
III experimental51,52,643±0,050,302±0,0170,294±0,0015
IV experimental52,02,665±0,0060,299±0.005 0,323±0,0088

In table 2 data show that mice treated with liquid concentrate of biologically active substances in quantities of 1 ml/bird per day, had a smaller weight of the liver and kidneys, indicating that the increase hepatotropic potential of the organism.

The histological examination of liver tissues noted that concentrate BAS exhibits hypocholesterolemic action, and hypotriglyceridemic effect in holding back the excessive accumulation of fat in the liver, which in turn prevents fatty degeneration of the liver. Therefore, the obtained concentrate of biologically active substances, has a hepatoprotective effect, protecting the liver from the harmful effects, and increases the metabolic activity of the primary filter in the body (see table 3).

Table 3
Histological examination of liver tissues of mice
GroupStudies on the liver
ControlAbundant accumulation of fat-like substances that are released during painting Sudan III. In addition, there are a variety of destructive effects, such as swelling of the nuclear structure of the ur, pikes kernel m vacuolization of the cytoplasm of hepatocytes. The number of binucleate cells is about 25% of the total number of hepatocytes.
I experiencedThe accumulation of fat-like substances, the prevalence of degenerative processes that occur on the background of metabolic disorders. A large number of young cells, liver restores its functions.
II experimentalHepatocytes do not have pronounced destructive changes, the relative amount of fat-like substances within physiological norms. When painting on the nucleic acid produces a large number of multinuclear cells in the synthetic stage, i.e. updating the cell contents of the gland.
III, IV, experimentalThe liver has no striking pathological changes, and processes similar 2 the experimental group.

Thus, the obtained from aspen wood, the biologically active substance concentrate is a natural hepatoprotective agent. The inventive method thereof is simple, convenient, economical, does not require large power consumption. Mild extraction conditions allow to obtain the maximum number of biologically active substances in the native form is high hepatoprotective activity.

The method of obtaining hepatoprotective funds from aspen wood, including the grinding of raw materials and its mechanical pressing, characterized in that is used as raw material waste aspen wood, which is crushed to a particle size less than 1 mm, then the previously air-dried to a moisture content of not more than 18%, soaked in water at a temperature of 18-25°C. when the ratio of raw material:solvent =1:1.5 to 2.5 for 10-24 h followed by extraction of the extract and concentrating it in vacuo at a temperature not exceeding 40°C. until a dry matter content of from 3.5 to 100%.



 

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