Set for dysbacteriosis treatment and treatment method
SUBSTANCE: invention relates medicine area, in particular, gastroenterology, and concerns treatment of GI tract dysbacteriosis. A set containing agents, possessing antagonist action on a GI tract pathogenic microflora and agents for restoration of a normal GI tract microflora (eubiotics and bacteritic preparations), and also independent GI tract electrostimulators are used for this purpose. The method of GI tract dysbacteriosis treatment combines a diet, the specified agents, and also electrostimulator insertion before and-or in the course of treatment.
EFFECT: optimum conditions for effect of eubiotics and bacteritic preparations at the expense of preliminary normalisation of GE tract motor and evacuation functions.
The invention relates to medicine, in particular to means and methods for treating pathologies of the intestine, and is primarily concerned with the treatment of a dysbacteriosis of the gastrointestinal tract.
One of the most common diseases of the gastrointestinal tract is the disruption of the bacterial microflora of the intestine and its rebirth, which in Russian medicine is a common name dysbacteriosis.
Widely used methods of treatment of a dysbacteriosis, based on the reception of preparations containing saturated bacterial component, available in various pharmaceutical forms, biologically active supplements (Bas) and some food products, such as bifidumbakterin, Narine, bifidokefir and many others [1-2].
Currently, the most common preparations of a group of "probiotics" - coordinators of life flora which is capable of metabolic activity.
It seems that this is the most physiological way of correction of dysbacteriosis, because probiotics have a positive impact on the functioning of the microflora of the host contribute to better adapt it to the environment. Probiotics are used as antimicrobial, antioxidant and enzymatic active agent in acute and protracted infections, bacteriological is conditionally pathogenic microbes.
Part of probiotics are spore-forming bacteria, bifidobacteria and lactobacilli, enterococci, yeast, acidophilus bacteria.
However, the activity of probiotics may occur only under certain conditions: preliminary suppression of pathogenic bacteria and fungi, normalization of metabolism of epithelial cells, the acidification of the environment, strengthen local immunological resistance of the cell.
To create such favorable conditions are safe, natural medicines, consisting of biologically active natural substances, vitamins, amino acids, antioxidants and trace elements.
Also known is a method of treatment of a dysbacteriosis effect on pathogenic microbial flora of the normal products of metabolism of microorganisms. These drugs include hilak Forte. He created 50 years ago to the present time is used for the treatment of patients with pathology of the intestine. Hilak Forte is a sterile concentrate products of the normal metabolism of the intestinal microflora: lactic acid, lactose, amino acids and fatty acids. These substances help to restore intestinal biological environment, essential to the existence of the normal microflora, and inhibit the growth of pathogenic bacteria.
It is also known that the dysbacteriosis of practice in the český always have a place motility disorders of the gastrointestinal tract, failures in the operation of peristaltic function. Observed how slow the passage of food in the intestine and, as a consequence, frequent, regular constipation, and acceleration of the rhythm of the contractions, which leads to the accelerated release of undigested food. As in the first and in the second case, seeding and engraftment of colonies of bacteria in the intestine is difficult. When slowing down the passage of food bacteria are largely eliminated acidic environment in the stomach and for the most part do not reach the intestine, their concentration is not sufficient to restore the bacterial component of the intestinal microflora. With the accelerating rhythm of the contractions of the muscles of the intestine, often causing diarrhoea, passing in bowel bacteria colonies do not have time to settle and multiply in the intestine due to too high speed movement of food through the intestines.
In either case it is reasonable and / or in the course of treatment to restore the normal, the natural rhythm of the contractions of the muscles of the intestines to clean the intestines from the settled toxins in it, figuratively speaking, to revive and to normalize the activity of the intestine".
Closest to the claimed is a set of drugs and the method of complex drug therapy, including diet and exercise antagonisticheskoe impact on the pathogenic flora of the gastrointestinal tract, the restoration of normal micro is Laura's stomach and maintain it by taking enzyme preparations, adsorbents, the enveloping means, eubiotics and bacterial preparations. As eubiotics use Interix and bactisubtil, as well as bacterial - bificol and hilak-Forte. Treatment: Interix 1 capsule 4 times a day after meals for 5-7 days, then baktisubtil 2 capsules 3 times daily between meals for 2 weeks, then bificol 5 doses 3 times a day for 40 minutes before meals for 2-3 weeks in the future impose this drug for 5 doses 2 times a day morning and evening for 40 minutes before meals and at lunch, add hilak 40 drops before meals for 4 weeks. Upon completion of the course of treatment to control feces analysis on disbacteriosis. The method includes taking medications, exercising antagonistic effects on pathogens, then restoring and maintaining the normal flora .
A common shortcoming of these methods is the desire to treat goiter without predvaritelnii normalization of motor-evacuation function of the gastrointestinal tract.
The basis of the invention is to increase the effectiveness of treatment of a dysbacteriosis of the gastrointestinal tract in the simplified method, reduction of time for its implementation and the reduction of complications.
The problem is solved by the introduction of a set of drugs for the treatment of a dysbacteriosis of the gastrointestinal tract Autonomous electrostatic damage to the module the battery of the gastrointestinal tract and its reception before and/or during adjuvant therapy, including diet and acceptance of products, engaged in antagonistic effects on pathogenic microflora of the gastrointestinal tract, restoration of normal microflora of the digestive tract and its further maintenance .
The Autonomous electrostimulator of gastrointestinal tract and enter the body orally, that is, by ingestion, is designed for electrical stimulation of the smooth muscles of the intestine pulses, imposing the intestines natural rhythm of peristaltic contractions. Using the so-called "muscle memory" structure to normalize bowel peristaltic function is sufficient relatively short-term stimulation of the muscles of the intestine. Standard time Autonomous electrical stimulator of gastrointestinal tract is 15-60 hours. This time is enough to impose the muscles of the intestine, the rhythm of the contractions in which the muscle worked in state of a healthy gut. Stimulated mode contractions of the intestine is a long time and ensures the normal functioning of all departments of the gastrointestinal tract.
At the same time Autonomous electrostimulator effectively cleans the intestines, removing of wastes and pathogens.
After some time (2-5 days) after exposure is and the Autonomous electrostimulator naturally from the body it is recommended to start taking drugs, contains the necessary bacteria in concentrations sufficient for their active healing in the intestine, and vitamins to address any identified mineral metabolism disorders.
If the efficiency of restoration of microflora and normalization of mineral metabolism is insufficient, repeat administration of the Autonomous electrostimulator, again prosimulium muscles of the intestine.
Important advantages of the method and its implementation are simplicity and accessibility, the security application of the Autonomous electrostimulator of gastrointestinal tract, its relatively low cost, high efficiency. This allows the use of the method and its implementation in wide clinical practice in the structures involved in the prevention, treatment and rehabilitation of patients.
Sources of information
1. I.N. Blokhina. and Dorofeyuk VG Dysbiosis, L., 1979;
2. The patent of Russian Federation №2150951 "Method of treatment of pseudoallergy", publ. 20.06.2000,
3. The Autonomous electrostimulator of gastrointestinal tract. Technical conditions. THE 9444-017-07543077-2004.
1. Kit for treatment of a dysbacteriosis of the gastrointestinal tract (GIT), containing the means of carrying out an antagonistic effect on pathogenic microflora of the gastrointestinal tract, restoration of normal microflora of the digestive tract and maintain it notable is that it additionally introduced Autonomous electrical stimulator of gastrointestinal tract.
2. The method of treatment of a dysbacteriosis of the gastrointestinal tract (GIT) by the use of adjuvant therapy, including diet and receiving funds, engaged in antagonistic effects on pathogenic microflora of the gastrointestinal tract (GIT), restoration of normal microflora of the digestive tract and its maintenance, characterized in that before and/or during the treatment of the bowel clean and restore his motor-evacuation function (peristalsis) by drinking the Autonomous electrostimulator of gastrointestinal tract.
SUBSTANCE: invention relates to novel compounds of general formula (I), their optically active stereoisomers, as well as to pharmaceutically acceptable salts possessing properties of ORL1 and µ-opiate receptors. In general formula , R1 represents H, alkyl(1-6C), m represents-(CH2)m-, in which m equals 0 or 1, R2 represents halogen, CF3, alkyl(1-6C), phenyl, cyano, cyanoalkyl(1-3C), hydroxy, (1-3C)alkoxy, OCF3, acyl(2-7C), trifluoroacetyl, (1-3C)alkylsulfonyl or trifluoromethylsulfonyl, and n represents integer number 0-4 on condition that when n equals 2, 3 or 4, R2 substituents can be similar or different, A represents saturated ring, 0 and p represents -(CH2)o and -(CH2)p, and o and p independently correspond to 0, 1 or 2, R3, R4, R5 and R6 independently represent hydrogen, alkyl(1-3C), or (R4 and R6) together can form alkylene bridge, containing 1-3 carbon atoms on condition that when o equals 2, R3 represents hydrogen, and when p equals 2, R5 represents hydrogen, R7 represents H, halogen, alkyl(1-6C). Invention also relates to pharmaceutical composition, intermediate compounds for obtaining formula (1) compounds.
EFFECT: compounds can be used for preparing medication for treating disorders and diseases such as alimentary behaviour disturbances, arterial hypertension.
8 cl, 3 dwg, 1 tbl, 45 ex
SUBSTANCE: invention concerns experimental medicine and can be used in veterinary science. The Ultrasorb preparation is fed to the animals that are on a vivarium standard diet, within 14 days, based on 3 g/day, admixed with forage. The way prevents development of intestinal dysbacteriosis at animals.
EFFECT: prevention of intestinal dysbacteriosis at animals.
3 ex, 2 tbl
SUBSTANCE: 24 hours prior to the examination, children aged 3 to 8 year old takes in 100 ml lactulose (Duphalac) with water of room temperature in amount 1-1.5 liters within 4-6 hours. The second dose lactulose (Duphalac) 100 ml follows with water of room temperature in amount 1-1.5 liters. To prevent overaerogenesis and to reduce discomfort, Espumisan (Simethicone) is prescribed in dosage 15 ml 3 times a day. For children aged 8 to 18 years old, there is prescribed 200 ml lactulose (Duphalac) with water of room temperature in amount 1.5-2.0 litres within 4-6 hours followed with the second dose of lactulose (Duphalac) 200 ml with water of room temperature in amount 1-1.5 litres. Additionally Espumisan (Simethicone) is introduced in dosage 15 ml 3 times a day or 3-6 capsules 3 times a day.
EFFECT: effective cleansing of gastrointestinal tract in children of different age, thus ensuring good visualisation of large intestine mucosa and decreasing drug load on organism of younger children, preserving normal microflora of large intestine and preventing overaerogenesis.
SUBSTANCE: there is prescribed gluten-free diet with eliminating cereals and additional order of protein: meat 100.0 g, cottage cheese 100.0 g, or sour cream 100.0 g daily. Creon is dosed 10000 ME at mealtime within 2 weeks. It is combined with physiotherapy exercises (PTE) within 20-30 minutes. During afternoon, every second day circular douche is applied at pressure 1.5-2 atmospheres, water temperature 36-35°C for 3-4 minutes within therapeutic course 10-12 procedures. On another days, radon baths are taken at water temperature 36°C, dosed 0.75 kBq/l for 8-10 minutes within therapeutic course 8-10 procedures. Electrophoresis is applied daily with 50% Dimexide solution (±) for small intestine projection by transverse technique, current density 0.05 mA/cm2 within 12-15 minutes within therapeutic course 10-12. The BAPs VC-20, VC-22, E-36, Gi-4 are exposed to red and infrared light daily within 1.5-2 minutes per each point within therapeutic course 10-12 procedures.
EFFECT: reduced specific immunologic markers of autoimmune intestine inflammations and cytokine generation level, normalised immune response of an organism, normalised hormonal and exchange processes.
2 ex, 2 tbl
SUBSTANCE: invention relates to experimental medicine and concerns pyelonephritis prevention in experiment. During 10 days preparation "Ultrasorb" is introduced to experimental animals with food in terms of 3 g/day. Then pyelonephritis is modelled by rectal infection with uropathogenic strain of lactose-negative E.Coli at the background of cold stress.
EFFECT: absence or reliable reduction of kidney tissue inflammation in animals which obtained "Ultrasorb".
SUBSTANCE: invention relates to medicine, namely to pediatrics and gastroenterology and can be used for treating intestine disbacteriosis in children less than 1 year old. For this purpose bifidumbacterin forte is introduced. First 2-3 days preparation is introduced by 25-30 doses per day in 4 takings. During next 3-4 weeks bifidumbacterin forte is introduced by 5 doses 2 times a day.
EFFECT: method allows increasing efficiency of treatment of disbacteriosis in children less than 1 year old due to application of definite scheme of preparation introduction first in optimally high dose mode, then in supporting doses.
SUBSTANCE: invention relates to medicine, in particular to gastroenterology, and applies to treatment of chronic duodenal obstruction. For this purpose erithromicin is introduced on account of 3.0 mg/kg of body weight 3 times a day. Additionally Alfadol-Ca is introduced in case of initial normocalcemia in dose 1 capsule 1 time a day. In case of initial hypocalcemia Alfadol-Ca dose is 1 capsule 2 times a day. Course of treatment is 3 months.
EFFECT: method ensures elimination of symptoms of chronic duodenal obstruction in patients with functional form of chronic duodenal obstruction in combination with syndrome of disturbed absorption and normalisation of calcium balance in organism.
2 dwg, 1 tbl, 2 ex
FIELD: medicine; gastroenterology.
SUBSTANCE: antibacterial therapy is presented with selective decontamination using antiklebsiellic bacteriophage within 10 days. After that prebiotic therapy including Hylak Forte, enzymatic agent and Linex in therapeutic dosage is combined with probiotic introduction. For dysbacteriosis of I stage Bifiform is introduced in dose 1 capsule 2 times a day, for dysbacteriosis of II and III stages dose is 2 capsules 2 times a day, combined with Lactobacterinum 5 doses once a day. Thus medicinal plant tincture is introduced including silverweed rootstock, salvia leaves, milfoil herb, St. John's wort herb, elecampane rootstock with roots, tickseed herb, mint leaves, fennel fruits and buckthorn bark at component ratio respectively 2:2:2:2:2:2:2:2:1 dosed 1\3 of glass 3 times a day, 30 min before meal, within 4 weeks.
EFFECT: method has no contraindications and provides fast normalisation of gastrointestinal tract microflora.
1 tbl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns medicine. A soft drink on the basis of herbs consists of the concentrated vegetative extract obtained from an admixture of herbs, chosen of Sida sps., Boerhaavia diffusa, Vitis vinifera, Tinospora cordifolia and Withania somnifera, along with green palm sugar, the agent causing a fermentation, and carbonised water, in which proportion Sida sps.: Boerhaavia diffusa: Vitis vinifera: Tinospora cordifolia: Withania somnifera in a powdery admixture makes (15-20 : (5-10 : (15-20 : (5-10 : (5-10); Proportion of wt/wt: green palm sugar: the concentrated vegetative extract makes from 1 : 3 to 1 : 4; wt/wt, a proportion of carbonised water: the admixture of the concentrated vegetative extract, green palm sugar and the agent causing a fermentation, makes from 1 : 3 to 1 : 5. Perform: (a) obtaining of parts of Sida sps., Boerhaavia diffusa, Vitis vinifera, Tinospora cordifolia and Withania somnifera; (b) crushing of parts of plants and their mixing with obtaining of a powdery admixture; (c) water addition to a powdery admixture from a stage (b) for obtaining of a water extract; (d) concentration of a water extract from the stage (c); (e) filtration of the concentrated extract from the stage (d); (f) admixture of green palm sugar to the filtered extract from the stage (e); (g) addition of Sacromyces strain and the agent causing fermentation, to the admixture from the stage (f); (h) fermentation of the admixture from the stage (g) during the period of time from 3 till 6 days; (i) filtration of the fermented admixture from the stage (h); (j) concentration of the fermented filtrate from the stage (i) with obtaining of the basic solution and (k) mixing of the basic solution (j) with the carbonised water in wt/wt proportion from 1 : 3 to 1 : 5 with obtaining of a soft drink on the basis of herbs.
EFFECT: creation of a soft drink on the basis of herbs.
11 cl, 5 tbl, 8 ex
FIELD: medicine; pharmacology.
SUBSTANCE: invention concerns production of herbal tea for prevention and complex treatment of intestinal disbacteriosis. The herbal tea includes cinquefoil rootstocks, salvia leaves, milfoil grass, St. John's wort grass, elecampane rootstock and roots, sticktight grass, mint leaves, fennel fruit and buckthorn bark in the ratio of 2:2:2:2:2:2:2:2:1 respectively.
EFFECT: extended medicine range for prevention and complex treatment of intestinal disbacteriosis by sanitation of opportunistic intestinal microflora.
SUBSTANCE: invention concerns medicine and is intended for treatment of patients with traumatic disease of spinal cord. The procedures including influence on muscles, participating in movement of lower limbs by an impulsive bipolar electric signal with amplitude varying within 20-100 mA, with the maximum duration 200-250 microseconds, 65 Hz frequency of following of impulses are spent daily. Movement of lower legs is simultaneously provided within 15-40 minutes by carrying out of passive-active trainings on a rehabilitational training apparatus - a bicycle. Procedure time is enlarged with each subsequent procedure for 5 minutes, leading up on 6th procedure to 40 minutes, and then the subsequent procedures take 40 minutes, by a course from 15 to 20 procedures.
EFFECT: increase of an animal force, volume of muscular mass of the lower legs, improvement of condition of superficial and deep sensitivity, intensifying of the control of function ofpelvic organs against the initial expressed disturbances.
SUBSTANCE: invention refers to medicine and covers therapy of patients suffering from pancreatic diabetes combined with central nervous system damage. The therapy involves intravenous infusion of Mexidol 5% 5.0 ml. In 30-35 minutes, the patient is exposed to transcerebral sinusoidal current of frequency 5000 Hz, modulated low-frequency oscillation with using fronto-occipital technique. The half-period duration is 1:1.5 in variable mode, III operation mode, modulation depth 75%, frequency 30 Hz. Current strength within 0.8 to 2.0 mA is dosed to sensation of easy, painless vibration. Duration of procedures is 15 minutes in therapeutic course 8-10 daily procedures.
EFFECT: method allows reducing frequency and intensity of headaches, degree of manifestation of depression and anxiety, improving state of health, memory, attention, cerebral circulation and putting the patient in good spirit, normalising sleep and blood lipids.
SUBSTANCE: invention concerns medicine and is intended for treatment of hypotonic-type functional constipations. Method involves application of electric current with neuron-like impulses generated by "Миоритм-040" aggregate to mesocolon projection points on skin. Three therapeutic channels of "Миоритм-040" aggregate are utilised. Electrodes are set in 6 procedure fields and connected to three aggregate channels. Electrostimulation duration is 10 minutes. Magnetic pulse field of 50 Hz frequency and 37.5 mTl flux density at work surface is applied before electric impulse current, by continuous movement of electromagnetic inductor over front peritoneal wall along mesocolon projection for 10 minutes. Medication treatment involving cholagogic drugs and probiotics and dietary therapy focused on probiotic food are performed.
EFFECT: improved blood circulation in mesocolon, reduced perineural edema, enhanced excitability and conduction of neuron fiber, reduced electric load on patient and duration of electrode application and fixation.
3 ex, 1 dwg
FIELD: medicine; arrhythmology.
SUBSTANCE: re-programming of implanted in patient's body double-chamber electric cardiostimulator to mode of atrial stimulation AAI is performed. At the same time under control of surface electrocardiogram, frequency-increasing atrial electric stimulation is carried out starting from frequency which is 10 pulses a minute higher than spontaneous sinus rhythm and increasing frequency of electrostimulation with 10-pulses-a-minute step until tachycardia-dependent second degree artrioventricular block is reached, initially and after that at each step of electrostimulation measurement of St-QRS interval is carried out, to measured St-QRS value 20-30 ms are added and it is considered optimal value of atrioventricular delay for each frequency stage and said values for each frequency are programmed into electrocardiostimulator as atrioventricular delay.
EFFECT: increase of efficiency of frequency-adaptive atrioventricular delay in patients with preserved atrioventricular conduction.
1 tbl, 2 dwg
SUBSTANCE: on the basis of diagnostic signs zone for electrostimulation influence is selected on skin. Electrodes connected to section with larger number of turns of good quality coil are applied to said zone. Section with smaller number of coil turns is connected between poles of constant voltage source through close electronic key. Starting level of energy of electrostimulating influence is set by supplying to electronic key inlet of opening pulses with minimal duration which does not cause pain sensations. Value of parametre, characterising frequency of electric fluctuations, influencing electric signal, from database which contains values of parametres of electrostinulating signals with comfortable perception characterising frequency of electric fluctuations and corresponding to them values of durations of opening pulses supplied to electronic key inlet, are measured. Duration of opening pulse, for which according to database value of parametre, characterising frequency of electric fluctuations of electrostinulating signal, corresponds to measured parametre of influencing electrostinulating signal, is determined. If duration of opening signal from database is longer than duration of opening pulse of influencing electrostinulating signal, duration of opening pulses of influencing electrostinulating signal is increased on discretisation unit. If duration is shorter, it is reduced on discretisation unit. If duration is equal, it is left without change.
EFFECT: objectification of energy of electrostinulating influence and elimination of appearance of pain sensations in patients during SCANNER-therapy.
5 cl, 5 dwg
FIELD: medicine; veterinary.
SUBSTANCE: method includes carrying out premedication by intramuscular injections of sedative medication with myorelaxation activity before surgery. After surgery dynamic electroneurostimulation by apparatus "ДЭНАС-ЗооДЭНС" is realised by pulse influence, duration of first impulse being 20-60 mcs, and amplitude of second impulse voltage being 50-150 V. Apparatus electrodes are placed on mucous membrane of sublingual area of cats. Dynamic electroneurostimulation is realised once during 5-10 minutes.
EFFECT: reduction of time necessary to recover from narcosis.
SUBSTANCE: 4 main femoral muscles are influenced by sinusoidal modulating variable currents during 10 min. Influence is carried out bipolarly with frequency 80 Hz with ratio "impulse-pause" 4-6 s with modulation depth at first two procedures 75-100%, at following 100-150%.
EFFECT: reduction of intensity of pain syndrome in knee joint and morning constraint, increase of movement amount in knee joints.
3 ex, 1 tbl
SUBSTANCE: invention relates to medicine, namely to arithmology, cardiology and cardiosurgery and is intended for invasive treatment of WPW syndrome connected with functioning of additional conducting tracts. Electrode is brought to heart by means of through-vein or thoracotomic access, after which mapping of fibrous atrioventricular rings is performed during atrial, ventricular electrostimulation and during orthodromic tachycardia, intervals St-V, St-A, V-A being measured. Having detected merging of atrial and ventricular potentials, further registration of said intervals is carried out not to the beginning but to the peak or ending of second potential of interval and detecting point with minimal value of intervals, it is considered zone where additional conducting tract is located.
EFFECT: method allows to increase accuracy of additional conducting ways mapping, reduce duration of both mapping stage and radio-frequency ablation stage.
1 ex, 1 dwg
SUBSTANCE: pluripolar electrode is pulled to a coronary sine using endovscular access and bipolar electrogrammes are registered. Thus during an atrial electrical stimulation potential of a left ventricle V is analysed, during a ventricular electrical stimulation or orthodromic tachycardia potential of the left auricle A is analysed, two interfacing electrogrammes are defined, where there was a change of polarity of the specified potentials from "+" to "-", or on the contrary and a site between the poles from where the given electrogrammes are registered. Consider as the location of an additional spending way where make radio-frequency ablation.
EFFECT: increase of mapping accuracy of left-sided additional pathways at patients with the WPW syndrome.
1 ex, 2 dwg
FIELD: medicine; otorhinolaryngology.
SUBSTANCE: transcranial electrical stimulation is ensured with direct and pulse current exposure through electrodes. Herewith current intensity is 1.5-2.0 mA. Exposure time is 30-40 minutes. Course of treatment includes 10-15 procedures.
EFFECT: tone correction of superior esophageal sphincter muscle, lower gastric secretion, larynx neogenesis.
1 tbl, 2 ex
SUBSTANCE: invention refers to bacterial strains Bifidobacterium adolescentis DSM 16594, DSM 16595, Bifidobacterium breve DSM 16596 and Bifidobacterium pseudocatenulatum DSM 16597 and DSM 16598, deposited in German Collection of Microorganisms and Cell Cultures producing folic acid. The probiotic composition contains at least one of strains been listed. There is provided application of bacterial strain chosen from the group including strain Bifidobacterium adolescentis DSM 16594, DSM 16595, Bifidobacterium breve DSM 16596 and Bifidobacterium pseudocatenulatum DSM 16597 and DSM 16598 to prepare the pharmaceutical composition used for treatment or prevention of disorders requiring introduction of folic acid.
EFFECT: that ensures high content of folic acid in large intestines regardless condition of the healthy patient.
19 cl, 1 tbl