Purulent wound repair technique
SUBSTANCE: treatment of the patients with purulent wounds is ensured by bathing of a purulent wound that is being in alterative and exudative inflammation phase, with physiologic saline. It is followed with registering fluorescence of the purulent wound within its depth, centre and infiltrate. Thereafter a factor K1=Iav/If is calculated, where Iav is an average fluorescence index of the wound within depth, centre and infiltrate, If is a standard fluorescing reference of a comparison object which is the fluorescence of earlap. Then the wound is sponged with a probiotic in amount 5.0-50.0 ml and more considering the wound extent. It is drained and loosely filled with a probiotic-saturated tampon. Thereafter an aseptic dressing is applied, and conventional integrated therapy is administered. Probiotic re-management of the wound is carried out once a day and more often, with multiple bathing of the purulent wound and fluorescence registration. Provided K1>>K2, where K2 is the fluorescence measured again in combination with the integrated therapy, the same is continued. Otherwise, the integrated therapy is corrected by changing an antibacterial preparation and/or prescribing the other antibacterial preparations and/or additional oral introduction of probiotic Euflorin L and B dosed 1 tablespoon 1-3 times a day. The therapy is prolonged until granulations are observed in the wound, and until K1>>Kn is provided, where Kn is a value verging towards fluorescence powers specific for intact tissues or varies no more than by 5-20%.
EFFECT: higher effectiveness of purulent wounds repair combined with integrated therapy without local application of antibacterial preparations owing to local introduction of probiotics in this case acting as antagonists to pyogenous flora of the wound.
The invention relates to medicine, in particular to the treatment of diseases and microbial processes of nature with the study of probiotic preparations.
The spectrum of clinical syndromes and pathological conditions, the pathogenesis of which is believed to be associated with changes in the composition and functions of the microflora inhabiting the skin and mucous membranes, in the present wide and has a tendency to increase (abscesses, phlegmon, diarrhea, constipation, colitis, gastritis, duodenitis, peptic ulcer ischemia, Hypo - and hypercholesterolemia, rheumatoid arthritis, various lesions of the connective tissue, malignant neoplasm of colon and breast cancer, menstrual irregularities, tooth decay, kidney stones, dermatitis, various allergic reactions, various liver damage, endo - and superinfection different localization and others).
Bacterial infections are the most frequent diseases in humans and animals throughout their lives. In recent years, the possibility of treatment of purulent-inflammatory diseases have increased significantly due to the emergence of a large number of new effective antimicrobial agents. However, the results of treatment of these diseases often remain unsatisfactory - slow flow, relapse, superinfection and, sometimes, death. The latter is most often noted is carried out with the complications of purulent-inflammatory diseases, such as sepsis, meningitis, mediastinic etc. it is Considered that only the observance of the conditions for the selection of effective drugs and protocols for the rapid diagnosis of purulent surgical infection and its treatment on the basis of rational use of antimicrobial drugs will reduce the frequency of purulent-inflammatory diseases and, thus, will lead to the reduction of treatment time (the biggest item of expenditure on medical care), and will reduce morbidity and mortality (Guidance on infection control in the hospital. TRANS. from English. Ed. Roncella, Tbrewer, J.-Pbutler. - Smolensk: IACMAC, 2003).
The combination of these provisions is compounded by the complications associated with nosocomial infection and translocation of microbes of the gastrointestinal tract in the focus of inflammation, especially against the uncontrolled intake of broad-spectrum antibiotics, which even more complicates the diagnosis of etiologic organisms, an adequate choice of therapeutic drug and thereby exacerbates the disease, complicates its treatment, and increases recovery time.
It is known that in modern clinical practice for local treatment of patients with purulent-inflammatory diseases are mainly used antibiotics and the following Antisept the ical preparations: furatsilin, Miramistin, chlorhexidine, dioxidine, himopsina, each of which has an antibacterial effect. In the work of S. Titova. "Development of a rapid method of selecting effective antiseptics for treatment of purulent wounds of the maxillofacial region", M., 2003, a comparative evaluation of drugs and found that at present the most effective products are the Miramistin and dioxidine. However, the author indicates that the individual choice of antiseptic should be based on objective evaluation using laser fluorescent diagnostics, because with this method it was shown that certain patients were effective furatsilin and himopsina, and some are not effective chlorhexidine and dioxidine. All this suggests that without an adequate method of control at the point of care the selection of antimicrobials for treatment of purulent wounds treatment may not be effective. In addition, it is known that antibiotics and antiseptics contribute to the development of allergic reactions, inhibit local and General, specific and nonspecific immunity, which complicates the treatment and exacerbates the disease. These same factors contribute to the emergence of drug resistant forms of bacteria, which leads to the need to change drug treatment and lengthens the time is ecene patient. This problem is a significant lack of technology, which we took as a prototype.
This allows us to put forward a position on the necessity of finding more effective treatments that do not have these disadvantages. Some of these promising drugs are probiotics, representing a comprehensive bio of live bifidobacteria and lactobacilli (eubiotics) and products of their metabolism (postbioptic).
These products are amino acids (aspartic, glutamic, folic acid, glycine, serine, Proline, histidine, tyrosine, tryptophan, valine, phenylalanine, isoleucine, lysine, alanine); low molecular weight proteins (peptides); organic acids (lactic, formic, acetic, propionic, Polenova); antibiotics of natural origin, including thermostable (acidophilus, lactocidine, Lactalis); vitamins C, D, B; enzymes, in particular lysozyme.
The complex, consisting of two active principles, inhibits the growth of putrefactive and pathogenic organisms, addresses the lack of normal microflora contributes to the destruction of toxic products of metabolism that are carcinogenic action of nitrite, lowers cholesterol and oxalates, contributes to the breakdown of lactose.
Liquid eubiotics enhance local immunity Sanir the bathrooms of their mucous membranes by increasing their lysozyme activity and secretion of IgA, and this, in turn, leads to expulsion from the cells of the mucous membranes of intracellular parasites, such as Mycoplasma, chlamydia, Listeria, not to mention the positive effect of liquid eubiotics on banal flora festering wounds.
The task to be solved by the invention is the development of medical technologies for wide multi-purpose and integrated use of liquid eubiotics that can provide high efficiency of treatment of purulent wounds without antibiotics and noticeable improvement organismic environment in conditions of deep ecological crisis.
However, these applications of probiotics require appropriate quality control and the frequency of application and evaluation of clinical effect in General.
For these purposes, the problem is solved by the fact that for assessing the quality probiotic preparation before its clinical application and to assess the clinical effect of the use of probiotics for the treatment of purulent surgical infection suggested to use the method of rapid diagnosis at the point of care is a method of laser fluorescent diagnostics. Technically for the treatment of purulent surgical infection method, as the object of the invention is as follows.
1. Opening purulent with subsequent local and systemic cured the patient eat with a group delay of CLO.
2. Lavage purulent wounds with saline solution in the amount of not less than 5.0 to 50.0 ml with the purpose of removal of necrotic masses from the wound and create a better contact of the pathogen with subsequent introduction into the wound of the probiotic.
3. Registration fluorescence festering wounds in the field of depth (Iك), mid (IC) and infiltration (AI), thus registering a maximum average power of a fluorescence: SR=Iك+IC+AI/3, normalized with K1 on similar indicators standard fluorescing object comparison (F), where K1=SR/F. As a comparison object using the fluorescence of the ear lobe after wiping it with 70%alcohol and drying in the open air.
4. Measure the power of a fluorescence probiotic and if she is not less than 140-150 relative units and/or corresponds to the capacity of fluorescence standardized according to GOST sample, proceed to washing purulent wounds.
5. Then the wound is washed with a probiotic, such as eufloria L, in the amount of not less than 5.0-50.0 ml depending on the volume of the wound, drain it and loosely fill the ball with a probiotic with the subsequent imposition of aseptic dressings and spend the conventional complex therapy of the disease.
6. Re-treatment of the wound probiotic carried out in the same volume, 1-2 times a day (as needed 2 or more), while treatments 2 and 3 repeat and by the tea if K1 K2, where K2 is the normalized indicator after repeated measurements, on the background of a comprehensive treatment, indicates a positive treatment outcome, and Vice versa, while in the latter case, correction of the treatment by changing antibiotic and/or additions of antimicrobial treatment of other antimicrobials (1-3 preparation) are not antagonists broad-spectrum and/or appoint additional intake of probiotic, such as eufloria L and per os 1 tablespoons 1-3 times a day.
7. Treatment in alterative-exudative phase of inflammation to spend until the wound appears granulation, with K1 KP, where KP is the value To approaching the capacity values of the fluorescence of intact tissue (int), i.e. KP=hit or differs from it by no more than 5-20%.
Such methodological and methodical approach allows to reduce the duration of treatment for patients with different degrees of severity, for example, purulent-inflammatory diseases in 2-5 days depending on the severity and extent of the pathological process.
Thus, the proposed medical technology meets the requirements of modern medical Metrology, as increases the effectiveness of the treatment, such as purulent surgical infection, reduces the period of rehabilitation of patients and contributes to a more rapid organ-specifies the WMD regeneration of tissues.
Clinical testing applications eufloria for the treatment of patients with purulent-inflammatory diseases of maxillofacial area
30-35% of all surgical pathology associated with purulent infection, and up to 7% of them can be fatal. According to Professor V. Roginsky (1998), over the last 5 years in Moscow the number of children with inflammatory processes in tissues of the maxillofacial area, which required hospitalization, increased more than 10 times. In addition to significant changes in the qualitative structure of hospitalized patients in maxillofacial hospitals occurred in recent years a considerable qualitative changes in the clinical course of acute purulent odontogenic inflammatory diseases of maxillofacial area: and often begin very rapidly, aggressive, and then proceed with the dramatic worsening of the General condition of patients and the spread of inflammation from one anatomical region to another.
To date, the most effective way of treatment of patients with inflammatory diseases of CLO is complex, which combines both surgical and conservative treatment, surgical treatment method lies in the opening of inflammation and the provision of adequate drainage him, and conservative - in conducting R the national antibiotic therapy in combination with detoxification drugs. 65% of patients have to spend 2-3 or more operations to apply the powerful complex of therapeutic measures, often reanimation character. Based on the above data, the problem of treatment and prevention of complications of inflammatory diseases of maxillofacial area is urgent and requires special consideration.
Research work on the evaluation of the use of probiotic preparations for the treatment of patients with purulent surgical infection (cellulitis, abscesses, carbuncles, furuncles) is "Scientific-production center of medical and industrial biotechnology "Spectrolux" (SPC Spectrolux) at the surgical Department of hospital dentistry MMA. Sechenov.
At the moment cured 129 patients with inflammatory diseases of CLO, mainly with phlegmon, carbuncles and furuncles, main group is 61 persons, a comparison group of 68 people. The main group match patients in treatment who used the above probiotic preparations group of eufloria. In the comparison group patients were treated in accordance with the existing rules for the treatment of inflammatory diseases of CLO. All patients after opening the inflammation climbed the biomaterial (wound) and, for example, who was little more than bacteriological analysis. The results are presented in tables 1 and 2.
The results of bacteriological studies of wound content of the patients before use of probiotic preparations
|The selected microorganisms||The biomaterial|
|Wound, COE/ml before and after|
|Staphylococcus aureus||101-108/growth no|
|Prevotella melaninogenica||107/growth no|
|Peptostreptococcus saccharalyticus||106/growth no|
|Streptococcus viridans group||101-107/growth no|
|Streptococcus sp.||105/growth no|
|Fusobactenum necriphorum||106-103/growth no|
|Propionibacterium granulosum||101-106/growth no|
|Actynomyces sp||103/growth no|
|Corynebacterium sp||103/growth no|
|Neisseria sp||104/growth no|
In some cases wound in the material growth of microorganisms was observed (52% of patients). On the first day after surgery, the wound surface was studied using the method LFD in the research process was measured symmetric intact region, the area of infiltration, the center of the wound periphery and the deepest part of the wound. This has resulted in the following pattern, indicating a decrease of fluorescence intensity of the pathological focus in the process of local treatment of purulent wounds with eufloria.
In addition to post-operative wound on the first day also investigated the substrate digestive tract using culture method and the method LTD. According to the results of bacteriological studies in patients with inflammatory diseases of CLO to ensure the state of the microflora of the gastrointestinal tract ranges from normalise to dysbiosis 2-3 degrees. According to the results obtained using LFD, indicators substrate gastrointestinal fluctuate at the beginning of treatment from 88.159 Ed. to 14.843 Ed. (Measures=60±3 Rel. units). After treatment, the maximum value corresponds Measures=83.49 Ed. (normal is 80-120 Rel. units), studies on personal leaves of patients occurred in the comparison group and the main group. The received data is redstavleny in the table below:
Comparative characteristics of patients with inflammatory diseases of CLO in the two groups.
|Bed-days in hospital||Cellulitis||Boils, carbuncles|
|MES (comparison group)||14||14|
|Clinical observation (main group)||12.6||8.7|
|N1=41 (the number of observed boils, carbuncles),|
N2=20 (the number of observed phlegmon),
N3=68 (comparison group: phlegmon 45, boils - 13).
|The formation of granulation||Cellulitis||Boils, carbuncles|
|The comparison group||11||11|
|The main group||8.3||4.2|
|N1=41, N2=20, N3=68.|
|Time sickness||Cellulitis||Boils, carbuncles|
|The comparison group||8||8|
|The main group||4.8||2.7|
|N1=41, N2=20, N3=68.|
|Time epithelialization||Cellulitis||Boils, carbuncles|
|The comparison group||13||13|
|N1=41, N2=20, N3=68.|
|Mild infiltration (day)||Cellulitis||Boils, carbuncles|
|The comparison group||12||12|
|The main group||9.8||4.4|
Thus, clinically, bacteriologically and method LFD shown high efficacy of probiotics (Autorin L and C) in the complex treatment of patients with purulent-inflammatory diseases of maxillofacial area. This is determined by a decreasing term sickness 3.5-5.3 days, mild edema of the inflammatory infiltrate at 2.2-7.6 days more rapid formation of granulation 2.7-7.8 days that, in General, determined the reduction in bed-days by 1.4-5.3 days.
The method of treatment of purulent wounds, including comprehensive treatment through the introduction of antibacterial agents and washing of the wound cavity with subsequent monitoring observation of the wound, characterized in that alterative-exudative phase of inflammation spend washing purulent wounds with saline solution, then record the fluorescence of purulent wounds in depth, mid and infiltration and calculate the index K1=SR/F where SR - average fluorescence wounds in depth, mid and infiltration, F - indicator standard fluorescense of the comparison object, which is used as a measure of the fluorescence of the ear lobe; then the wound is washed probiotic in the amount of not less than 5,0-50,0 ml depending on the volume of the wound, drain it and loosely fill the ball with a probiotic with the subsequent imposition of aseptic dressings and conduct generally accepted comprehensive treatment, re-treatment of the wound probiotic spend 1 or more times per day, while washing purulent wounds and registration fluorescence repeat, and if K1>>K2, where K2 is the rate of fluorescence after repeated measurements on the background of complex treatment, then continue the same treatment in another Kucharova correction of complex treatment by changing antibiotic and/or additions other antibacterial drugs and/or appoint additional oral administration of the probiotic of eufloria L and In 1 tablespoon 1-3 times a day; treatment until the wound granulation, as well as to compliance with conditions, when K1>>Kn, where Kn is the value of approaching the capacity values of the fluorescence of intact tissue or differs from it by no more than 5-20%.
SUBSTANCE: invention concerns medicine. The device implanted into a human body or an animal is described, containing the bioblasted polymer including units of ethylene carbonate of the formula (A): -(-C(O)-CH2-CH2-O-)- (A), in number of 70-100 molar % which possesses internal viscosity 0.4-4.0 dl/g at determination in chloroform at 20°C in concentration of 1 g/dl and 5-50°C vitrification temperature, blasted at the expense of superficial erosion which is supervised on the mechanism of non-hydrolytic scission.
EFFECT: restoration of normal blood flow and keeping an artery opened after installation of a balloon catheter.
13 cl, 1 dwg, 2 ex
SUBSTANCE: invention concerns medicine, namely, to abdominal surgery, and can be used for prevention of formation of postoperative adhesions of serous cavities. For this purpose deserosed and-or the inflamed sites of organs and a cavity wall are covered with an admixture of sterile gel "Lintexum-Mesogel" and derinate during an operative measure on organs of serous cavities. Derinate volume makes from 1% to 25% from all volume of the admixture. The way allows preventing development of adherent process in abdominal cavity in the postoperative period without additional administration of other medicinal preparations during this period at the expense of local prolonged immunopotentiation provision and consolidation prevention of deserosed surfaces.
EFFECT: prevention of development of adherent process in abdominal cavity in the postoperative period without additional administration of other medicinal preparations during this period at the expense of local prolonged immunopotentiation provision and consolidation prevention of deserosed surfaces.
2 tbl, 1 ex
SUBSTANCE: invention refers to medicine, namely to surgery, and can be used in healing of wound surfaces ensured as follows. Before the wound surfaces are closed with skin transplant, it is covered with a special film made of mixed beet high-purity pectin and Tamerite taken in ratio 5:1.
EFFECT: method allows for considerable reduction of wound healing time due to combination of antiseptic and sorptive properties of pectin and immunomodulatory property of Tamerite taken in optimal ratio.
11 dwg, 1 tbl, 1 ex
SUBSTANCE: invention refers to medicine and veterinary science, and can be used particularly for disconnection of the affected pulmonary region from ventilation with using programmed cell loss phenomenon (apoptosis). The device for chemicals delivery to bronchial tubes and other hollow organs of biological objects comprises two reservoirs inserted one inside the other. The reservoirs have apertures in their walls that are combined in relative relocation of the reservoirs to ensure escape of the interior reservoir content beyond the external reservoir within therapeutic action on the organ.
EFFECT: ease of fabrication.
SUBSTANCE: invention refers to medicine, namely to urgent surgery, and can be used in treatment of closed pancreas injuries ensured by examination performed in admission to hospital. If there are two signed detected, including increase of glucose in blood 10 mmol/l and higher in combination with hyperamylasemia 300 standard units and more; pancreas expansion with lower parenchyma echogenicity diagnosed by ultrasound; pancreas haemorrhage; observed effusion in omental bursa at amylase activity 2 times exceeding that of blood, certain mixture is perfused into retroperitoneal parapancreatic fat. The mixture contains 0.25% Novocaine solution 250 ml, Trasylol 150 units, 0.1% Dimedrol solution 1.0 ml, heparin 5000 units, 2.0% Papaverine solution 2.0 ml and Cephepime 1.0 g. Perfusion is to lower amylase content is blood to 200 standard units. Besides omental bursa is sanitised with 5% ε-aminocapronic acid solution.
EFFECT: method improves clinical effectiveness for the patients suffering from closed pancreas injuries and prevents heavy complications including traumatic omentobursitis, peritonitis, parapancreatitis and retroperitoneal phlegmons without direct organ surgery.
SUBSTANCE: invention relates to medicine and veterinary and can be used for destruction of biological tissues affected by pathological process. For this purpose by means of hollow metal needle concentrated solution of sodium acetate with temperature of boiling 110-120°C is introduced into biological tissue. Then biological tissue is heated with high-frequency current at temperature of current-conducting needle surface 1-2°C lower than solution boiling temperature. 3-5 ml of solution are introduced at rate 0.3-0.5 ml/min before heating and 0.1-0.2 ml/min in process of heating.
EFFECT: method allows to increase efficiency of heat transmission into biological tissue, reduce traumaticity and labour-intensiveness of biological tissue thermocoagulation procedure due to increase of coagulation volume during one session, suggested mode of introduction rate excludes possibility of leakage of introduced solution.
SUBSTANCE: invention relates to medicine, namely to otolaryngology, and can be used for treating adhesive otitis. For this purpose operational intrusion on middle ear is performed. At final stage of operation 0.2-0.5 ml of 4% gel of carboxymethylcellulose sodium salt (Na-CMC) is introduced.
EFFECT: improvement of morphological and functional result of operative intrusion due to turning on mechanism of scar formation process slowing down.
2 cl, 3 ex, 1 dwg
SUBSTANCE: invention concerns medicine, namely to cardiosurgery and can be used as measures on prevention of suppurative and septic complications at cardiac surgery operative measures spent in the conditions of an artificial circulation. For this purpose an antibiotic is entered within the first days after operation. The next days a probiotic is entered. As a probiotic, Sporobacterin preparation in liquid suspension is administered perorally in a dose of 2-5 ml, 2-3 times a day within 7-12 days.
EFFECT: method allows to provide as much as possible effective protection against implications of a surgical infection at the given category of patients at the expense of restoration of anti-infectious resistance to a wide spectrum of contagiums owing to application of the big probiotic doses, and also considerably to lower a medicinal load as a result of unitary introduction of an antibiotic.
3 tbl, 4 ex
FIELD: medicine; surgery.
SUBSTANCE: treatment of temporal paresis of recurrent laryngeal nerve caused by extensive thyroid gland operations is ensured with insertion of a catheter under parietal layer of 4th cervical fascia within recurrent laryngeal nerve arborisation at the end of operative intervention. Then the following medical preparations are injected through this catheter: 0.05% proserin solution 1 ml, dexamethasone solution 1 ml (4 mg) and 1% dibazole solution 2 ml. Injection is continued in postoperative period as well once a day within 3-5 days. At the end of injection course catheter is removed.
EFFECT: higher efficiency of treatment of temporal paresis of recurrent laryngeal nerve, ensured by highest concentration of medical preparations within required region, thus affecting various pathogenesis components of the given pathology.
FIELD: medicine; intensive care.
SUBSTANCE: for enteral tube feeding in gastroduodenal hemorrhage operations cases, microsonde is introduced to patient. Before nutrients administration, 1.5 to 2.0 liters of solution containing 1 dose of "Fortrans" preparation to 1 liter boiled water is introduced; infusion rate being 40 to 60 drops during 6 to 8 hours.
EFFECT: reduced early recovery period of motor-evacuation function, increased nutritive maintenance efficiency, postoperative complications and lethality prevention due to early clearing of bowels from hemolysed blood.
2 ex, 2 dwg
SUBSTANCE: Fomitopsis officinalis Tyv-2006 All Russian Collection of Industrial Microorganisms F-961 basidiomycete strain characterised with high activity to malignant cells can also be used for making antineoplastic drugs.
EFFECT: extended range of agents with anticancer activity.
2 tbl, 2 ex
SUBSTANCE: method is ensured as follows. During 30 days, a patient takes orally probiotic Sporobacterin dosed 1 ml twice a day. Said therapeutic course is repeated every six months.
EFFECT: method provides increase in number of T-helpers according to the trend of immunoregulating coefficient CD4/CD8 of HIV-positive patients.
FIELD: veterinary medicine.
SUBSTANCE: dry bacterial compound contains, at least for 10% on a weight basis of total compound, the dry bacterial concentrate having bacteria concentration of at least 1×108 CFU/g and water activity of less than 0.5, and stabiliser having water activity of less than 0.5 at water content of 10%. There also provided is packed bacterial compound, batched compound and stabilisation method of dry bacterial compound by mixing thereof with stabiliser having water activity of less than 0.5 at water content of 10%; at that, total bacterial compound has water activity of less than 0.5. Treatment method of the mammal requiring treatment involves introduction of batched compound according to the present invention.
EFFECT: improved stability of the product, and higher number of bacteria per the product dose.
26 cl, 1 dwg, 1 tbl, 14 ex
SUBSTANCE: invention concerns medicine, particularly phthisiatry, and can be applied in pulmonary tuberculosis treatment. Method involves peroral administration of oxymethyluracil (OMU) in amount of 0.5 g twice per day for 10 days in addition to traditional antibacterial therapy and bacrisporin probiotic.
EFFECT: OMU application together with bactisporin allows for accelerated elimination of mycobacteria and inflammation reduction in foci, amplified immunomodulating effect of bactisporin due to oxymethyluracil effect on functional metabolic activity of blood phagocytes.
3 tbl, 2 ex
FIELD: food products, pharmacology.
SUBSTANCE: food or pharmacological composition with anti-inflammatory properties contains one or several lactobacillus plantarum strains chosen from the group consisting of Lactobacillus plantarum strain DSM 15312 - tannase producer, Lactobacillus plantarum strain DSM 15316 - tannase producer and tannins. Above mentioned Lactobacillus plantarum strains are used combined with tannins to obtain medicine for preventive or medical treatment of cardiovascular diseases, diabetes, inflammatory bowel diseases, irritable bowel syndrome, gastrointestinal infections, malignant swelling, Alzheimer disease or diseases of autoimmune origin as well as for preservation of food products and for manufacturing of food product.
EFFECT: improved tannase activity and improved agility for adnation of cells of large bowel mucous membrane when composition is used.
9 cl, 1 dwg, 4 tbl
FIELD: medicine; gynecology.
SUBSTANCE: for treatment of chronic inflammatory diseases of small pelvis organs at the background of complex therapy, including antibacterial therapy, which is carried out systematically or locally, biovestin-lacto is introduced in dose 3-6 ml perorally 2 times a day for 6-8 weeks.
EFFECT: reduction of recurrences of chronic inflammatory diseases of small pelvis organs during six months after treatment.
2 cl, 5 tbl, 1 dwg
FIELD: food products.
SUBSTANCE: method of biological active additive production includes three-staged processing of yeast cells water suspension with exogenous ferments to obtain target product in the form of fermentolisate. During the first and the second stage the initial and secondary zymogene compositions are used. The initial zymogene composition contains for 1 g of dried yeast 0.05-5.0 activity of proteinase and 10.0-50.0 activity units of mix of endo-beta-gluconase and exo-beta-gluconase. The secondary zymogene composition contains 50.0-300.0 activity units of mix of endo-beta-gluconase and exo-beta-gluconase, 5.0-20.0 activity units of mannanase and 0.01-0.5 activity units of chitinase. The processing of yeast cells suspension of the initial zymogene composition is performed at 54-56°C during 1 hour 45 min. - 2 hours 15 min. The processing of the secondary zymogene composition obtained after the first stage is performed at 45-48°C during 3 hour 45 min. - 4 hours 15 min. During the third stage processing of the obtained mass is performed with ferments of the secondary zymogene composition at temperature of 35-38°C during 6-12 hours. The product output equals 92%, the concentration of amine nitrogen is 6.3%.
EFFECT: obtaining of target product with high output and high aminoacid content.
8 cl, 3 ex
SUBSTANCE: invention refers to medicine, particularly to therapy and can be used for undifferentiated connective displasy (UCD) correction. Method involves introduction of the medicinal agent intended for normalising gut organisms and containing bifidus bacteria in therapeutic doses 20-30 min before meals within 3-4 weeks.
EFFECT: when prescribed, the medicinal agent containing bifidus bacteria allows for direct connective metabolism control thus lowering and improving activity of the antioxidant systems.
6 ex, 1 tbl
FIELD: food products.
SUBSTANCE: method includes sterilisation of skimmed milk with dry materials content of 16%, cooling to the temperature of souring, introduction of maticular starter Lactobacillus acidophilus strain 317/402 and 0.1%, dry starter Lactobacillus acidophilus strain 317/402 and cultivation. The obtained starter is cooled down, held, frozen at the temperature of -45°C during 23 hours and capsulated. Then it is vacuum dried during 22 hours to the humidity of 2.9 wt %. Lactis acid bacellus of living cells content in the finished starter before and after capsulation equals (3.5-4.0)·1010KOE/g.
EFFECT: increase of starter solubility and activity with improved taste and increased storage life.
4 tbl, 1 ex
SUBSTANCE: invention concerns medicine, in particular, gastroenterology, and concerns treatments of a peptic ulcer of a stomach and a duodenum, associated with Helicobacter pylori. For this purpose introduction of antihelicobacter antibiotics and a Linex medication is performed. Upon termination of the course of treatment with antihelicobacter antibiotics it is continued to administer Linex medication on 2 capsules 3 times a day within 3 days.
EFFECT: method allows warning development of implications of the dysbacteriosis caused by reception of antihelicobacter antibiotics, and also provides cupping of dyspeptic implications within 3 days after cancellation of antibiotics at any duration of the course.
FIELD: medicine; nephrology.
SUBSTANCE: evaluation of IgA, IgM, IgG levels is combined with calculation of y1 and y2 values by linear discriminator (LD) equation of general formula: where C is a constant, xi represents informative signs, namely x1 is IgA level, x2 is IgM level, x3 is IgG level, ai represents factors for specified signs. Two y values are calculated with factors a related to each y value; and C constant by formulas: y1=-6.958+0.298x1+1.935x2+0.272x3; y2=-5.668+0.688x1+1.559x2+0.175x3. Provided y2 exceeds y1, a patient is referred to the group without chronic renal insufficiency. In case y1 exceeds y2, a patient is considered to be related to the group of patients suffering from chronic renal insufficiency.
EFFECT: improved performance of diagnostics that further ensures effective realisation of set of actions aiming at prevention of the given pathology.