Softening agent for thick and viscous pus

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to pharmacy, surgery and phthisiology and can be applied for lavage of pleural cavity in pleural empyema. There is offered softening agent for thick and viscous pus. The offered agent is an aqueous antiseptic solution containing 2.7-3.3% of hydrogen peroxide and 5.0-10.0% of hydrocarbonate sodium.

EFFECT: invention provides reduced cost at higher speed, effectiveness and safety of softening the thick and viscous pus due to shorter range of specific weight and alkalinity herewith ensuring optimal alkaline hydrolysis of pus and physical destruction of purulent mass by means of intratissual divergent multiple aerogenesis.

 

The invention relates to medicine, in particular to the pharmacy, surgery and tuberculosis, and can be used for irrigation of the pleural cavity with tubercular empyema.

Known piperazinone and hyperosmotic antiseptic containing 30.3% of hydrogen peroxide, 0.9 to 10.0% of sodium chloride, carbon dioxide to create excess pressure of 0.2 ATM at +8C, with the additional introduction of 2,4-24% of aminophylline (Urakova N.A., Urakov A.L., Chereshnev V.A. et al. Hyperrational, giperbolichnosti, hyperosmolarity, HyperTerminal, hypersalinity and high surface activity of the solution as factors increasing its flushing activity. // Chemical physics and mesoscopy. - 2007. - V.9, No. 3. - S-262).

Specified antiseptic agent has a high cost, low speed, efficiency and security liquefy thick and sticky purulent masses inside the pleural cavity. The fact that the presence in solution of sodium chloride in the range 0.9-10.0% of aminophylline in the range of 2.4-24% does not guarantee the drowning solution in purulent masses due to the instability weight solution in comparison with purulent masses, as purulent masses have the largest specific weight in the range of 1,020-1,040 g/cm3. In this regard, solutions with a content of 0.9 to 1.5% sodium chloride and 2.4% of aminophylline have a specific gravity below 1,040 g/is m 3the density less than the density of thick purulent masses, and solutions with a total content of sodium chloride and aminophylline more than 4% have a specific gravity above 1,040 g/cm3the density higher than the density of thick purulent masses. Therefore, the medium containing sodium chloride in the range from 0.9 to 10% and aminophylline in the range of 2.4-24%, can be both easier and harder pus.

Instability values of specific weight means reduces the predictability of the direction of movement in it purulent masses under the influence of gravitational forces, after interaction means with pus, which reduces the speed and efficiency of liquefaction thick and sticky pus.

In addition, the presence in the vehicle up to 10% of sodium chloride decreases due to excessive "salinity" thinning action of aminophylline, and the additional introduction in this overly salty tool up to 24% of aminophylline provides means even more pronounced excessive hyperosmotic activity, condensing pus due to dehydration and can cause excessive dehydration of living tissues, their nonspecific damage for 2-3 minutes interaction due to excessive dehydration and necrosis. Moreover, nonspecific dehydration and hypersaline damage cells may acquire irreversible after 5-6 minutes of continuous interaction with the specified R is the target.

Excessively high concentration in the sodium chloride and aminophylline increases the cost of funds and increases it up to excessive values hyperosmotic activity that reduces the security of its introduction into the patient due to dehydratation cell damage in living tissues.

In addition, hyperresonant means provides a rapid ascent up the money by violent gassing that removes up only some parts thick and sticky pus only when the tool is inserted from below, i.e. is brought under the weight of pus. Moreover, the application leads to the fact that a significant portion of the injected solution immediately moves upward due to the expansion and facilitation tools and sticky and thick pus may remain at the bottom, and the tool does not provide its rapid dilution, because initially causes thickening of pus due to its dehydration. Therefore, when the introduction of the solution into a closed cavity filled with a thick sticky pus, the solution is not able to throw out all the pus. In conditionally closed purulent cavity solution moves some purulent masses up. The solution provides the release up not so sticky and thick pus, but to himself. After the cessation of intensive application of this solution remaining in the purulent cavity, contains thick and sticky pus, the solution ensures high speed and efficiency of its liquefaction due to the persistent separation of environments and thickening of pus due to its dehydration. In these conditions, quick and full interaction amounts of pus and mortar between them becomes impossible, because impossible is the rapid dilution of pus and complete mixing of the liquid pus with a solution. Therefore, the physico-chemical interaction between the pus and the solution occurs only on the boundary separating their environments, which reduces the speed and efficiency of liquefaction thick and sticky purulent masses. An excessively high hyperosmotic activity means prevents diffusion means inside purulent conglomerate, because this prevents an intensive process of dehydration, i.e. the process of thickening bunch of pus.

Moreover, the tool due to the content of 2,4-24% of aminophylline does not have a stable value and the optimal range of alkalinity, as aminophylline has no buffer properties. In particular, solutions with a content of 2.4% of aminophylline have an alkalinity in the range of pH of 9.0, and solutions 24% of aminophylline have an alkalinity in the range of pH to 12.0. Therefore, the tool due to the high concentration of aminophylline has excessively high alkalinity and can cause alkaline denaturation, inflammation and burns living tissues, is he purulent mass. The probability of a cauterizing action increases with the duration of contact means with tissues. Therefore, the tool does not provide a secure saponification and liquefaction of thick and sticky pus, requiring intra-pleural cavity with tubercular empyema increasing the duration of continuous interaction with the tool.

However, the selection of molecular oxygen and the formation of gas bubbles in the solution, not having a stable high specific gravity and a stable optimum alkalinity, does not provide high speed and efficiency of the dissolution and destruction of thick and sticky pus. In particular, because of the excessively high alkalinity agent containing aminophylline, the tool can cause alkaline hydrolysis and destruction of living tissues when extending the period of continuous interaction with them more than 2-3 minutes.

In addition, medium, containing carbon dioxide to create excess pressure of 0.2 ATM at +8C, requires a special device for the storage and safe introduction into the closed cavity, which increases the cost of funds. Additional introduction of 2,4-24% of aminophylline also further enhances its value.

The purpose of the invention is reducing the cost while increasing the speed, efficiency and security liquefy thick and sticky pus through serenidipity specific gravity and alkalinity.

This objective is achieved in that the means for thinning thick and sticky pus containing 30.3% of hydrogen peroxide, soluble sodium salt and water as the sodium salt contains sodium bicarbonate in the following ratio, wt.%:

The peroxide2,7-3,3
Sodium bicarbonate5,0-10,0
Water for injectionRest

The introduction of the alkaline and relatively heavy solution (solution having indicators of alkalinity in the range of pH 8.0-8.5 and given weight in the range 1,045-kgs 1,090 g/cm3) hydrogen peroxide at a concentration of 30,3% ensures high speed and efficiency of liquefaction thick and sticky pus due misusage, destructive, flotation and suspension actions on pus. Optimal alkaline properties provide chemical saponification purulent mass on the border of the separation media and diffusive penetration of the solution into a festering mass without damaging living tissues surrounding purulent mass in the cavity of the body. The presence of a peroxide provides interstitial release of molecular oxygen, the formation of gas bubbles Velde thin pus, the destruction of the "monolithic" structure purulent mass, the adhesion of bubbles with thin and crushed particles of pus, separation of these particles from the main mass of pus, moving them up (ascent) and stirring the solution with viscous and crushed particles of pus.

The use of sodium bicarbonate in a concentration higher than 5,0% provides reliable increase in the normalized relative weight means higher 1,045 g/cm3while ensuring its alkalinity with pH in the range of 8.0 to 8.5, which is necessary for reliable and efficient separation of particles thick and sticky pus from the main mass of pus or other surface tissues by increasing the force pushing pus from a solution without excessive alkalization and without damaging alkaline hydrolysis of living tissues. The use of sodium bicarbonate in a concentration of up to 10.0% is explained, on the one hand, the real limit to the possible increase of its concentration by creating a saturated solution of hydrogen peroxide solution at room temperature, and on the other hand, the lack of local toxicity of saturated solution of sodium bicarbonate due to limitations of the measure of alkalinity within pH 8.5 due to buffer properties of sodium bicarbonate.

Introduction to the solution of 30.3% of hydrogen peroxide soluble salts of sodium hydrocarb the Nata at a concentration of 5.0-10.0% reduces the cost of funds, ensures optimal values of specific gravity greater than the density of thick and sticky pus, and stabilizes the performance of alkalinity in the safe and effective range of pH values.

The solution is designed to liquefy thick and sticky pus, may be infused from above in the closed cavity filled with thick purulent masses, and left it for 5-10 minutes for the rapid thinning of pus due to its saponification on the border of environments by means of an optimum alkalinity while drowning solution of pus under the force of gravity. The penetration of the solution down and deep into the bottom of purulent mass is, on the one hand, due to gravity, since the specific weight of the solution of higher specific gravity of pus, and on the other hand, due to the process of effective physico-chemical liquefaction and hydrodynamic destruction of pus on the border of separation of environments occurring in the layer purulent mass located under the solution, inside and above the solution by saponification of pus alkaline agent and at the expense of vnutrennego (interstitial) "boiling" of the solution by diffusion of a solution containing hydrogen peroxide, purulent mass. In addition, the process of diffusion of the solution into a festering mass optimized occurring by the formation of molecular oxygen from a solution containing PE ekici hydrogen. Due to the adhesion of particles pus emerging gas bubbles lift them up when afloat in a solution having a higher density than pus. Due to continuous gassing and flotation is provided by the dispersion of viscous purulent environment and the suspending solution. Moreover, the intensity of the process gas of molecular oxygen from the hydrogen peroxide is determined by the activity of catalase, which contains significant amount of it in purulent masses. Therefore, the gas occurs in the layer of interfacial interaction between the two environments: solution and pus. Molecular oxygen under these conditions rationally is used to destroy the thick purulent conglomerates, because the tool provides due to the high specific weight and measure alkalinity and lower interstitial "boiling". In addition, oxygen is efficiently used for flotation softened particles of pus, dispersing and suspending media.

Therefore, this tool is low cost, creates optimal conditions for safe fast and efficient liquefaction of thick and sticky pus, so it increases the effectiveness of local treatment of purulent-inflammatory processes, reduces the likelihood of developing septic complications, reduces the frequency of surgical interventions, the mind is nishaat duration and cost of treatment.

Us model conditions was reproduced in the liquefaction process purulent masses proposed by the tool. Models served 6 transparent plastic bags with a volume of 20 ml with the top and bottom drainage holes each. In each of the packages was introduced in 5 ml of serous-purulent content taken from the pleural cavity of the patient with tuberculous empyema. Using tripods packages were suspended vertically with oppositely placed drainage holes and inserted them in the drainage pipes on the laboratory bench at room temperature. Then in every capacity from above through the upper drainage was introduced in 5 ml of solution.

In the first package was introduced a solution containing 3% hydrogen peroxide and 0.05% antifibrin, the second package was introduced a solution containing 3% hydrogen peroxide, 0.9% sodium chloride and carbon dioxide to create excess pressure of 0.2 ATM at +8C, in the third package was introduced a solution containing 3% hydrogen peroxide, 10% sodium chloride and carbon dioxide to create excess pressure of 0.2 ATM at +8C, in the fourth package was introduced a solution containing 3% hydrogen peroxide, 10% sodium chloride, 2,4% of aminophylline and carbon dioxide to create excess pressure of 0.2 ATM at +8C, in the fifth package was introduced a solution containing 3% hydrogen peroxide and 5% sodium bicarbonate, the pole is the first package was introduced solution, containing 3% hydrogen peroxide and saturated (10%) of sodium bicarbonate. After that, through the transparent walls of the packages were watching their content. While the following is established.

In the first batch immediately after introduction of the solution it appeared small (diameter less than 1 mm) gas bubbles rising up to the surface of the package content, where the bubbles burst and disappeared. When this gas formation occurred over a layer of pus, and the process of surfacing bubbles up accompanied by slight stirring serous-purulent content, with the most "dense" part of the pus has not changed its location at the bottom of the package. Thick and sticky pus and lay almost unchanged at the bottom of the package during 60 minutes of observation. The subsequent pouring of the solution from the package did not lead to deletion of thick and sticky pus.

In the second batch immediately after introducing the solution, there was intense gas, in which a significant portion of pus rose up, but then emerged conglomerates pus settled to the bottom. The subsequent process of gassing has occurred over the mass of thick and sticky pus, not razzhizhaya it. After 60 minutes of observation purulent mass continued to be at the bottom of the package is not liquefied. The subsequent pouring of the solution from the package did not lead to deletion of HUS the CSOs and sticky pus.

In the third batch immediately after introducing the solution, there was intense flatulence, in which almost the entire mass of pus has risen up and is a solid mass above the solution. The separation of the environments and the top position of purulent masses remained virtually unchanged for 60 minutes of observation. The subsequent pouring of the solution from the package did not lead to deletion of thick and sticky pus.

In the fourth batch immediately after introducing the solution, there was intense flatulence, in which almost the entire mass of pus has risen up and is a solid mass above the solution. The separation of the environments and the top position of purulent masses remained unchanged for 15 minutes. Almost immediately began changing patterns of pus as the part of him which remained stuck at the bottom of the package, and one that has been surfaced on the solution. It was shown slight destruction of the peripheral layers of pus in the process of interstitial "boiling" and gassing. Formed in the surface layers of the festering mass of the gas bubbles tore off pieces of pus, stirring the solution, depriving him of transparency and increasing turbidity. After 25 minutes, "monolith" thick pus was completely destroyed, there was a complete liquefaction of the entire volume of the mA thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.

The fifth package immediately after introduction of the solution began liquefaction cancer and the emergence of small conglomerates up. By the end of the first minute after injection of the solution occurred ascent of almost all of the mass of pus up and continued dilution of pus as that part of it that remained at the bottom, and the one that surfaced over the solution. The solution was Motel literally "eyes" of the mass of the crushed particles destructible and soluble pus. Purulent mass was destroyed due to what is happening in her intensive process of "boiling point", i.e. the interstitial gas. Formed in the festering mass of the gas bubbles tore off pieces of purulent masses and pulled them up, stirring the solution, depriving him of transparency and increasing turbidity. After 10 minutes, the "monolith" thick pus was completely destroyed, there was a complete liquefaction of the total volume of thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.

In the sixth package immediately after introduction of the solution began liquefaction cancer. With almost all of purulent mass surfaced from the bottom of the package in the upper layers of a solution within a few seconds after introduction of the solution. Intensive RA is the liquefaction of pus occurred in all parts of pus, including those that remained stuck to the bottom, and those that came up. The solution was Motel literally "eyes" from appearing in the mist of soluble and destructible pus. Purulent mass was destroyed due to taking place in the interstitial intensive process of "boiling point", i.e. the interstitial gas. Formed in purulent tissue gas bubbles tore off pieces of purulent masses and moved them up, stirring the solution and turning it from clear to turbid. After 10 minutes all the "solid" part of thick pus was completely destroyed, there was a complete liquefaction of the total volume of thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.

Means for thinning thick and sticky pus containing 30.3% of hydrogen peroxide, soluble salt of sodium and water, characterized in that as the sodium salt contains sodium bicarbonate in the following ratio, wt.%:

The peroxide2,7-3,3
Sodium bicarbonate5,0-10,0
Water for injectionRest



 

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3 ex, 4 cl

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to cardiosurgery and can be used in operations on heart. Invention proposes a cardioplegic solution for intraoperation protection of myocardium containing the following components, ml: 5% KCl solution, 11-14; 5% NaHCO3 solution, 4-6; 25% MgSO4 solution, 1-2; 15% mannitol solution, 12-15; 40% glucose solution, 0.5-2; 10% calcium gluconate solution, 1-2, and 0.9% NaCl solution up to 100 ml Prepared solution is mixed with autoblood in the ratio 1:4. The claimed invention allows decreasing dose of inotropic support in post-operation period and to reduce possibility of negative results after operation on heart.

EFFECT: valuable medicinal properties of solution.

1 tbl

FIELD: medicine, pharmaceutical.

SUBSTANCE: invention relates to solid composition for treatment of reflux esophagitis, gastritis, or ulcers, method for production thereof and uses in therapy. Claimed composition contains alginate, bicarbonate and/or carbonate, and poly(C1-C5-alkylene glycol) hawing molecular mass of at least 6000 in amount of 1-50 %.

EFFECT: composition of decreased foam-forming properties and improved organoleptic characteristics.

12 cl, 18 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in therapy of breast cancer with bone metastasis. Substance of the invention consists in puncture with a needle between III and IV lumbar vertebras in subarachnoid spinal marrow space. Cerebrospinal fluid in amount 2 ml is poured in a sterile bottle and added with Epitalamine 10 mg. The bottle is incubated in a thermostat at temperature 37C within 20 minutes. Then the prepared mixed liquor and Epitalamine are introduced back into subarachnoid space that is combined with introduction of hydrocortisone 125 mg. The therapeutic course includes 4 lumbal punctures with introduction of preparations once a week.

EFFECT: application of the invention provides regress of bone metastases, reduced toxic collateral reactions of hormonotherapy, immune correction ensured by combined endoliquor introduction of said agents.

2 ex

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