Softening agent for thick and viscous pus
SUBSTANCE: invention refers to medicine, particularly to pharmacy, surgery and phthisiology and can be applied for lavage of pleural cavity in pleural empyema. There is offered softening agent for thick and viscous pus. The offered agent is an aqueous antiseptic solution containing 2.7-3.3% of hydrogen peroxide and 5.0-10.0% of hydrocarbonate sodium.
EFFECT: invention provides reduced cost at higher speed, effectiveness and safety of softening the thick and viscous pus due to shorter range of specific weight and alkalinity herewith ensuring optimal alkaline hydrolysis of pus and physical destruction of purulent mass by means of intratissual divergent multiple aerogenesis.
The invention relates to medicine, in particular to the pharmacy, surgery and tuberculosis, and can be used for irrigation of the pleural cavity with tubercular empyema.
Known piperazinone and hyperosmotic antiseptic containing 3±0.3% of hydrogen peroxide, 0.9 to 10.0% of sodium chloride, carbon dioxide to create excess pressure of 0.2 ATM at +8°C, with the additional introduction of 2,4-24% of aminophylline (Urakova N.A., Urakov A.L., Chereshnev V.A. et al. Hyperrational, giperbolichnosti, hyperosmolarity, HyperTerminal, hypersalinity and high surface activity of the solution as factors increasing its flushing activity. // Chemical physics and mesoscopy. - 2007. - V.9, No. 3. - S-262).
Specified antiseptic agent has a high cost, low speed, efficiency and security liquefy thick and sticky purulent masses inside the pleural cavity. The fact that the presence in solution of sodium chloride in the range 0.9-10.0% of aminophylline in the range of 2.4-24% does not guarantee the drowning solution in purulent masses due to the instability weight solution in comparison with purulent masses, as purulent masses have the largest specific weight in the range of 1,020-1,040 g/cm3. In this regard, solutions with a content of 0.9 to 1.5% sodium chloride and 2.4% of aminophylline have a specific gravity below 1,040 g/is m 3the density less than the density of thick purulent masses, and solutions with a total content of sodium chloride and aminophylline more than 4% have a specific gravity above 1,040 g/cm3the density higher than the density of thick purulent masses. Therefore, the medium containing sodium chloride in the range from 0.9 to 10% and aminophylline in the range of 2.4-24%, can be both easier and harder pus.
Instability values of specific weight means reduces the predictability of the direction of movement in it purulent masses under the influence of gravitational forces, after interaction means with pus, which reduces the speed and efficiency of liquefaction thick and sticky pus.
In addition, the presence in the vehicle up to 10% of sodium chloride decreases due to excessive "salinity" thinning action of aminophylline, and the additional introduction in this overly salty tool up to 24% of aminophylline provides means even more pronounced excessive hyperosmotic activity, condensing pus due to dehydration and can cause excessive dehydration of living tissues, their nonspecific damage for 2-3 minutes interaction due to excessive dehydration and necrosis. Moreover, nonspecific dehydration and hypersaline damage cells may acquire irreversible after 5-6 minutes of continuous interaction with the specified R is the target.
Excessively high concentration in the sodium chloride and aminophylline increases the cost of funds and increases it up to excessive values hyperosmotic activity that reduces the security of its introduction into the patient due to dehydratation cell damage in living tissues.
In addition, hyperresonant means provides a rapid ascent up the money by violent gassing that removes up only some parts thick and sticky pus only when the tool is inserted from below, i.e. is brought under the weight of pus. Moreover, the application leads to the fact that a significant portion of the injected solution immediately moves upward due to the expansion and facilitation tools and sticky and thick pus may remain at the bottom, and the tool does not provide its rapid dilution, because initially causes thickening of pus due to its dehydration. Therefore, when the introduction of the solution into a closed cavity filled with a thick sticky pus, the solution is not able to throw out all the pus. In conditionally closed purulent cavity solution moves some purulent masses up. The solution provides the release up not so sticky and thick pus, but to himself. After the cessation of intensive application of this solution remaining in the purulent cavity, contains thick and sticky pus, the solution ensures high speed and efficiency of its liquefaction due to the persistent separation of environments and thickening of pus due to its dehydration. In these conditions, quick and full interaction amounts of pus and mortar between them becomes impossible, because impossible is the rapid dilution of pus and complete mixing of the liquid pus with a solution. Therefore, the physico-chemical interaction between the pus and the solution occurs only on the boundary separating their environments, which reduces the speed and efficiency of liquefaction thick and sticky purulent masses. An excessively high hyperosmotic activity means prevents diffusion means inside purulent conglomerate, because this prevents an intensive process of dehydration, i.e. the process of thickening bunch of pus.
Moreover, the tool due to the content of 2,4-24% of aminophylline does not have a stable value and the optimal range of alkalinity, as aminophylline has no buffer properties. In particular, solutions with a content of 2.4% of aminophylline have an alkalinity in the range of pH of 9.0, and solutions 24% of aminophylline have an alkalinity in the range of pH to 12.0. Therefore, the tool due to the high concentration of aminophylline has excessively high alkalinity and can cause alkaline denaturation, inflammation and burns living tissues, is he purulent mass. The probability of a cauterizing action increases with the duration of contact means with tissues. Therefore, the tool does not provide a secure saponification and liquefaction of thick and sticky pus, requiring intra-pleural cavity with tubercular empyema increasing the duration of continuous interaction with the tool.
However, the selection of molecular oxygen and the formation of gas bubbles in the solution, not having a stable high specific gravity and a stable optimum alkalinity, does not provide high speed and efficiency of the dissolution and destruction of thick and sticky pus. In particular, because of the excessively high alkalinity agent containing aminophylline, the tool can cause alkaline hydrolysis and destruction of living tissues when extending the period of continuous interaction with them more than 2-3 minutes.
In addition, medium, containing carbon dioxide to create excess pressure of 0.2 ATM at +8°C, requires a special device for the storage and safe introduction into the closed cavity, which increases the cost of funds. Additional introduction of 2,4-24% of aminophylline also further enhances its value.
The purpose of the invention is reducing the cost while increasing the speed, efficiency and security liquefy thick and sticky pus through serenidipity specific gravity and alkalinity.
This objective is achieved in that the means for thinning thick and sticky pus containing 3±0.3% of hydrogen peroxide, soluble sodium salt and water as the sodium salt contains sodium bicarbonate in the following ratio, wt.%:
|Water for injection||Rest|
The introduction of the alkaline and relatively heavy solution (solution having indicators of alkalinity in the range of pH 8.0-8.5 and given weight in the range 1,045-kgs 1,090 g/cm3) hydrogen peroxide at a concentration of 3±0,3% ensures high speed and efficiency of liquefaction thick and sticky pus due misusage, destructive, flotation and suspension actions on pus. Optimal alkaline properties provide chemical saponification purulent mass on the border of the separation media and diffusive penetration of the solution into a festering mass without damaging living tissues surrounding purulent mass in the cavity of the body. The presence of a peroxide provides interstitial release of molecular oxygen, the formation of gas bubbles Velde thin pus, the destruction of the "monolithic" structure purulent mass, the adhesion of bubbles with thin and crushed particles of pus, separation of these particles from the main mass of pus, moving them up (ascent) and stirring the solution with viscous and crushed particles of pus.
The use of sodium bicarbonate in a concentration higher than 5,0% provides reliable increase in the normalized relative weight means higher 1,045 g/cm3while ensuring its alkalinity with pH in the range of 8.0 to 8.5, which is necessary for reliable and efficient separation of particles thick and sticky pus from the main mass of pus or other surface tissues by increasing the force pushing pus from a solution without excessive alkalization and without damaging alkaline hydrolysis of living tissues. The use of sodium bicarbonate in a concentration of up to 10.0% is explained, on the one hand, the real limit to the possible increase of its concentration by creating a saturated solution of hydrogen peroxide solution at room temperature, and on the other hand, the lack of local toxicity of saturated solution of sodium bicarbonate due to limitations of the measure of alkalinity within pH 8.5 due to buffer properties of sodium bicarbonate.
Introduction to the solution of 3±0.3% of hydrogen peroxide soluble salts of sodium hydrocarb the Nata at a concentration of 5.0-10.0% reduces the cost of funds, ensures optimal values of specific gravity greater than the density of thick and sticky pus, and stabilizes the performance of alkalinity in the safe and effective range of pH values.
The solution is designed to liquefy thick and sticky pus, may be infused from above in the closed cavity filled with thick purulent masses, and left it for 5-10 minutes for the rapid thinning of pus due to its saponification on the border of environments by means of an optimum alkalinity while drowning solution of pus under the force of gravity. The penetration of the solution down and deep into the bottom of purulent mass is, on the one hand, due to gravity, since the specific weight of the solution of higher specific gravity of pus, and on the other hand, due to the process of effective physico-chemical liquefaction and hydrodynamic destruction of pus on the border of separation of environments occurring in the layer purulent mass located under the solution, inside and above the solution by saponification of pus alkaline agent and at the expense of vnutrennego (interstitial) "boiling" of the solution by diffusion of a solution containing hydrogen peroxide, purulent mass. In addition, the process of diffusion of the solution into a festering mass optimized occurring by the formation of molecular oxygen from a solution containing PE ekici hydrogen. Due to the adhesion of particles pus emerging gas bubbles lift them up when afloat in a solution having a higher density than pus. Due to continuous gassing and flotation is provided by the dispersion of viscous purulent environment and the suspending solution. Moreover, the intensity of the process gas of molecular oxygen from the hydrogen peroxide is determined by the activity of catalase, which contains significant amount of it in purulent masses. Therefore, the gas occurs in the layer of interfacial interaction between the two environments: solution and pus. Molecular oxygen under these conditions rationally is used to destroy the thick purulent conglomerates, because the tool provides due to the high specific weight and measure alkalinity and lower interstitial "boiling". In addition, oxygen is efficiently used for flotation softened particles of pus, dispersing and suspending media.
Therefore, this tool is low cost, creates optimal conditions for safe fast and efficient liquefaction of thick and sticky pus, so it increases the effectiveness of local treatment of purulent-inflammatory processes, reduces the likelihood of developing septic complications, reduces the frequency of surgical interventions, the mind is nishaat duration and cost of treatment.
Us model conditions was reproduced in the liquefaction process purulent masses proposed by the tool. Models served 6 transparent plastic bags with a volume of 20 ml with the top and bottom drainage holes each. In each of the packages was introduced in 5 ml of serous-purulent content taken from the pleural cavity of the patient with tuberculous empyema. Using tripods packages were suspended vertically with oppositely placed drainage holes and inserted them in the drainage pipes on the laboratory bench at room temperature. Then in every capacity from above through the upper drainage was introduced in 5 ml of solution.
In the first package was introduced a solution containing 3% hydrogen peroxide and 0.05% antifibrin, the second package was introduced a solution containing 3% hydrogen peroxide, 0.9% sodium chloride and carbon dioxide to create excess pressure of 0.2 ATM at +8°C, in the third package was introduced a solution containing 3% hydrogen peroxide, 10% sodium chloride and carbon dioxide to create excess pressure of 0.2 ATM at +8°C, in the fourth package was introduced a solution containing 3% hydrogen peroxide, 10% sodium chloride, 2,4% of aminophylline and carbon dioxide to create excess pressure of 0.2 ATM at +8°C, in the fifth package was introduced a solution containing 3% hydrogen peroxide and 5% sodium bicarbonate, the pole is the first package was introduced solution, containing 3% hydrogen peroxide and saturated (10%) of sodium bicarbonate. After that, through the transparent walls of the packages were watching their content. While the following is established.
In the first batch immediately after introduction of the solution it appeared small (diameter less than 1 mm) gas bubbles rising up to the surface of the package content, where the bubbles burst and disappeared. When this gas formation occurred over a layer of pus, and the process of surfacing bubbles up accompanied by slight stirring serous-purulent content, with the most "dense" part of the pus has not changed its location at the bottom of the package. Thick and sticky pus and lay almost unchanged at the bottom of the package during 60 minutes of observation. The subsequent pouring of the solution from the package did not lead to deletion of thick and sticky pus.
In the second batch immediately after introducing the solution, there was intense gas, in which a significant portion of pus rose up, but then emerged conglomerates pus settled to the bottom. The subsequent process of gassing has occurred over the mass of thick and sticky pus, not razzhizhaya it. After 60 minutes of observation purulent mass continued to be at the bottom of the package is not liquefied. The subsequent pouring of the solution from the package did not lead to deletion of HUS the CSOs and sticky pus.
In the third batch immediately after introducing the solution, there was intense flatulence, in which almost the entire mass of pus has risen up and is a solid mass above the solution. The separation of the environments and the top position of purulent masses remained virtually unchanged for 60 minutes of observation. The subsequent pouring of the solution from the package did not lead to deletion of thick and sticky pus.
In the fourth batch immediately after introducing the solution, there was intense flatulence, in which almost the entire mass of pus has risen up and is a solid mass above the solution. The separation of the environments and the top position of purulent masses remained unchanged for 15 minutes. Almost immediately began changing patterns of pus as the part of him which remained stuck at the bottom of the package, and one that has been surfaced on the solution. It was shown slight destruction of the peripheral layers of pus in the process of interstitial "boiling" and gassing. Formed in the surface layers of the festering mass of the gas bubbles tore off pieces of pus, stirring the solution, depriving him of transparency and increasing turbidity. After 25 minutes, "monolith" thick pus was completely destroyed, there was a complete liquefaction of the entire volume of the mA thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.
The fifth package immediately after introduction of the solution began liquefaction cancer and the emergence of small conglomerates up. By the end of the first minute after injection of the solution occurred ascent of almost all of the mass of pus up and continued dilution of pus as that part of it that remained at the bottom, and the one that surfaced over the solution. The solution was Motel literally "eyes" of the mass of the crushed particles destructible and soluble pus. Purulent mass was destroyed due to what is happening in her intensive process of "boiling point", i.e. the interstitial gas. Formed in the festering mass of the gas bubbles tore off pieces of purulent masses and pulled them up, stirring the solution, depriving him of transparency and increasing turbidity. After 10 minutes, the "monolith" thick pus was completely destroyed, there was a complete liquefaction of the total volume of thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.
In the sixth package immediately after introduction of the solution began liquefaction cancer. With almost all of purulent mass surfaced from the bottom of the package in the upper layers of a solution within a few seconds after introduction of the solution. Intensive RA is the liquefaction of pus occurred in all parts of pus, including those that remained stuck to the bottom, and those that came up. The solution was Motel literally "eyes" from appearing in the mist of soluble and destructible pus. Purulent mass was destroyed due to taking place in the interstitial intensive process of "boiling point", i.e. the interstitial gas. Formed in purulent tissue gas bubbles tore off pieces of purulent masses and moved them up, stirring the solution and turning it from clear to turbid. After 10 minutes all the "solid" part of thick pus was completely destroyed, there was a complete liquefaction of the total volume of thick and sticky pus. The subsequent pouring of the solution of the package resulted in deletion of almost the entire liquefied pus.
Means for thinning thick and sticky pus containing 3±0.3% of hydrogen peroxide, soluble salt of sodium and water, characterized in that as the sodium salt contains sodium bicarbonate in the following ratio, wt.%:
|Water for injection||Rest|
FIELD: medicine; phthisiology.
SUBSTANCE: in addition to standard antituberculous therapy, hydrogen peroxide is injected to patient from the first day of treatment in homeopathic potency 6 CH by 5 granules 3 times per day for four months.
EFFECT: reduction of abacillation terms and closure of decay cavities due to higher activity of catalase, lower level of endogeneous hydrogen peroxide level and production of destructive factors, and activation of isoniazid under effect of potentiated hydrogen peroxide.
2 tbl, 2 ex
SUBSTANCE: thoracocentesis is performed followed by cavity flushing with aseptic solution and active aspiration. Further sanitated pleuropulmonary cavity is filled by 1/3 of its volume by antiseptic fluid including 1.7 ml of 33% hydrogen peroxide solution, 0.8 ml of 85% formic acid solution and up to 100 ml of glycerin. Then this solution is exposed until overflow feeling appears, and fluid volume accumulated in pleuropulmonary cavity is removed.
EFFECT: accelerated removal of necrotic areas and pus from purulent pleuropulmonary cavity without side effects and complications due to multidirectional effect of the solution components.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, particularly, to pharmaceutical vaginal compositions for treatment or prevention of vaginal infections. Composition contains synergistic mixture of bioadhesive medicinal form of prolonged release which reduces value pH and includes peroxide in amount, sufficient to increase oxygen concentration without either vagina sterilisation or considerable destruction of normal required local vaginal flora. Invention also refers to method of treatment or prevention of vaginal infections, including vaginal introduction of pharmaceutical vaginal compositions in amount, sufficient to decrease pH and increase in oxygen concentration without either vagina sterilisations or considerable destruction of normal desirable local vaginal flora.
EFFECT: development of effective method of treatment and prevention of vaginal infections.
35 cl, 1 tbl, 1 ex
FIELD: medicine; gynecology.
SUBSTANCE: puerpera with puerperal subinvolution of uterus and/or puerperal endometritis is instrumentally examined for uterine bulk within neck greatest extension. Puerpera's body is positioned so that upper end of uterus fundus is located lower than low end of uterine neck opening till uterine cavity is completely filled with blood. Catheter is pre-inserted to uterine neck fundus. Then uterine cavity is filled with warmed-up +42 - +45°C solution of mixed 0.9% sodium chloride and 3% hydrogen peroxide, through catheter. Then uterine cavity is US examined for position of thick objects and catheter, which is consistently brought to contact each thick object within point of attachment to uterus, followed with renewed introduction of solution. This procedure is accompanied with longitudinal forward motions of catheter with transverse vibration is introduced to this points to provide objects torn away from uterine wall until complete removal of all thick objects from uterine cavity. Then uterine cavity is filled with warmed-up +42 - +45°C dehydrated silicone gel soaked with % hydrogen peroxide in amount exceeding half of cavity bulk.
EFFECT: provided non-traumatic clearance of thick blood bunches from uterine cavity; clearance of amniotic sac under visual control; stimulation of coagulating system; prolonged disinfection of uterine cavity walls and activated contractive activity of uterus.
SUBSTANCE: method involves removing hematoma from cavity by means of puncture needle. Then, 3% hydrogen peroxide solution is introduced into the cavity through the same needle in the amount of one-half taken blood volume and left for 3-5 min. Then, the hydrogen peroxide solution is removed and ozonized biological glue is introduced into the cavity in the amount equal to 1/4-1/3 of aspirated blood volume. The hematoma localization area pressed with tampon for 2-3 min.
EFFECT: reliable hemostasis; accelerated wound cleansing; improved recovery process.
FIELD: medicine, surgery.
SUBSTANCE: the present innovation refers to treating osseous cavity in patients with chronic post-traumatic osteomyelitis, so, after necrsequestrectomy one should irrigate an osseous cavity with aqueous solution of sodium chloride, then it is necessary to treat the cavity with 3%-hydrogen peroxide solution with subsequent removal of foam with 0.02%-chlorohexidine bigluconate aqueous solution. Then twice during 1 min it is necessary to treat osseous cavity with 0.9%-ozonized sodium chloride solution at ozone concentration being 9000-10000 mgl/l. After that, one should introduce the mixture of anti-infectious chemotherapeutic preparations along with ultrasound cavitation for 3 min at frequency of 40 kHz followed by treating the cavity with the flow of nitrogen monoxide for 5 min at concentration being 5000 mg/cu. m. The innovation enables to increase penetrating capacity of medicinal preparations due to matching the desired mode of cavitary treatment.
EFFECT: higher efficiency of antiseptic treatment.
FIELD: medicine; radiological diagnostics.
SUBSTANCE: method can be used for diagnosing endometriosis of uterus and for estimating state of post-operational scars of myometrium as well as for visualizing bases of subserous and submucous myomatous uterus nodes. Uterus cavity is filled with contrast matter. Hydrogen peroxide solution is used as contrast matter in non-toxic amount; solution is injected in bolus dosing. Before injection sizes of uterus cavity are measured additionally and expected limiting volume V of filling of uterus cavity is calculated from relation of V=0,1a1h2, where h is length of uterus cavity, and a1 is width of uterus cavity at bottom of uterus. In accordance with expected limiting volume of filling, amount of injected echo-contrast matter is chosen while taking its rejection along uterus tubes into account. Uterus cavity is filled in dosage-by-dosage to make sure that there is no drainage of matter trough uterus neck and limiting volume of filling of cavity is kept. Appearance of echo-contrast matter is scars of myometrium, in myometrium, onto parietal and visceral peritoneum is estimated at moment of injection of contrast matter or later.
EFFECT: improved precision of inspection.
4 l, 16 dwg, 4 ex
FIELD: medicine, diagnostics.
SUBSTANCE: the present innovation deals with functional radiation diagnostics of uterine tubes, ureters, bile-excretory pathways and so on. It is necessary to carry out ultrasound research, organ's echocontrasting technique, introduction of sterile hydrogen peroxide solution in nontoxic dosage followed finally by evaluation of the results obtained. Moreover, ultrasound research should be conducted under conditions of local intracavitary anesthesia, either due to endocavitary or transabdominal access in three stages. At the first stage one should fulfill organ's echocontrasting due to introduction of a contrast sound-conducting substance into organ's cavity, fix permeability of the latter into a hollow organ under testing, adjacent organs and cavities, detect the volume and structure of a hollow organ, the availability of pathological neoplasms and evaluate functional state of an organ. At the second stage, organ's echocontrasting should be fulfilled due to introducing a sterile hydrogen peroxide solution directly into a hollow organ, according to gaseous bubbles it is necessary to evaluate anatomical structures, the availability of pathological deviations and echocontrast movement. As for the third stage, it should be carried out about 3-6 min after removing a catheter out of the cavity, due to echocontrasting the organ with residual gaseous bubbles it is possible to evaluate the state of hollow organs according to physiological movement of bubbles along the hollow organ in real period of time followed by introduction of sterile hydrogen peroxide with the help of a catheter applied under conditions of local intracavitary anesthesia, concentration of hydrogen peroxide in solution should be equal to 0.30-0.33%. The innovation enables to detect different pathology of a hollow organ, evaluate both anatomical and physiological alterations in organs.
EFFECT: higher accuracy of detection.
4 cl, 8 ex
SUBSTANCE: method involves providing double-staged processing of physiological salt solution with ozone, first stage including bubbling of physiological salt solution with ozone-oxygen mixture having ozone concentration of 3 mg/l to 10 mg/l at ozonizer outlet end, and second stage including additionally introducing ozone-oxygen mixture into the same bottle under pressure of from 1.5 atm to 2.9 atm, said mixture having ozone concentration of from 6 mg/l to 10 mg/l.
EFFECT: increased time of keeping ozone in physiological salt solution.
3 tbl, 1 ex
FIELD: medicine, obstetrics, gynecology.
SUBSTANCE: due to instrumental technique one should pre-detect the volume of uterine cavity and its longest length against the cervix. Moreover, it is necessary to fix a woman's body in position at which the upper edge of uterine cavity bottom is below against the lower edge of uterine cervical opening till the moment of complete filling in uterine cavity with blood. With the help of a catheter one should introduce medicinal preparation heated up to +42- +45° C into uterine cavity through an opening in uterine cervix into area of cavitary bottom at the volume exceeding the half of cavitary volume. Moreover, as the above-mentioned medicinal preparation it is necessary to apply dehydrated silicone gel impregnated with equal volume of 3%-hydrogen peroxide solution. The innovation enables to interrupt postpartum hypotonic uterine hemorrhage efficiently and safely.
EFFECT: higher efficiency.
SUBSTANCE: invention refers to medicine and biochemistry and concerns method for making a chewing product for enamel remineralisation including the stages as follows: a) preparation of aqueous solution of at least one acidifier, e.g., chosen from the group including carboxylic acids and fruit acids; b) addition of reaction calcium source; c) mixing the solution with a thickener representing gelatine; d) thorough agitation of the components for product preparation; e) extrusion and drying of the product characterised that at least at one stage phosphoric acid is added.
EFFECT: invention ensures a transparent and homogeneous gelatine chewing product with high calcium and phosphate concentration for remineralisation.
7 cl, 5 ex, 1 dwg
SUBSTANCE: antacid composition contains sodium alginate, antacid soluble agent or combination of antacids, proton pump inhibitor, diluent and sweeteners. Up to 30% of sodium alginate, present in composition together with total amount of proton pump inhibitor, are homogenously distributed throughout the surface of soluble antacid agent or combination of antacids of composition, remaining amount of sodium alginate, present in composition, has humidity less than 2%. Composition ensures stability of proton pump inhibitor.
EFFECT: composition performs quick and prolonged neutralisation of stomach acidity with protective effect in respect to stomach mucous coat.
23 cl, 3 dwg, 6 ex
FIELD: medicine; gastroenterology.
SUBSTANCE: development of ulcerative duodenum disorders is prevented with magnesium-bearing composition containing as follows: natural polymineral complex Bischofite 52-55 g, magnesium carbonate 45-48 g, sodium carboxymethyl cellulose - 0.8-1.0 g as 2% aqueous solutions.
EFFECT: apparent antisecretory action, ulceration minimisation.
2 tbl, 3 ex
FIELD: medicine; gastroenterology.
SUBSTANCE: after patient has been diagnosed with normal values of serum lipids, apolipoproteid B and balanced processes of lipid peroxidation (POL) and phosphatidyl serine (PS) that is less or equal to 10.4%, content of sphingomyelins (SP) from 24.1% to 27.6%, value of phosphatidyl ethanolamine (PE) equal or more than 29.2%, ratio of phosphatidyl choline PC/PE below 1.2, and also index of fatty acids unsaturation (IFAU) from 160.1 to 165.7, hypolipidemic dietotherapy (HD) is realised with enterosorbent hitamine or with taking of carbonated mineral water (CMW) and electrophoresis of mud extraction (EME) to liver area. If total cholesterol (TC) value is 5.0 -5.3 mM/l, cholesterol of low density lipoproteins (CLDL) is 2.9-3.3 mM/l and triglycerides make ≤0.9 mM/l, apolipoproteid B is ≤ 61.0 mg/dl, and (POL) lipid peroxidation processes are balanced with antioxidant protection (AOP) on the background of phosphatidyl serine content of 10.5%-13.6%, sphingomyelines content is ≤24.1% and IFAU makes 150.-160.0, HD is prescribed in complex with essential phospholipids (EP) or with enterosorbent hitamine with taking of HCMW and EME to liver area. If TC content is ≥5.4 mM/l, CLDL is ≥3.4 mM/l, CLDL is ≥1.7 mM/l, apolipoproteid B makes 112.0-183.0 mg/dl and total antioxidant activity of blood is ≤49% in combination of PC of 32.9%-33.4%, PE 27.6%-29.1%, ratio of PC/PE of 1.2 and IFAU is ≤150.4, HD is prescribed with inclusion of EP.
EFFECT: differentiated adequate pathogenetically oriented lipid-correcting therapy for this contingent of patients.
1 tbl, 1 ex, 1 dwg
FIELD: medicine; sexual pathology.
SUBSTANCE: Sildenafil citrate dosed 12.5 mg or Tadalafil dosed 5 mg is introduced 1 hour prior to expected coitus and combined with Vicalin dosed 1 tablet. Method allows for lowered dosage of specified phosphodiesterase inhibitors type 5 in 2-4 times.
EFFECT: effective treatment without by-effects.
FIELD: medicine; intensive care.
SUBSTANCE: for enteral tube feeding in gastroduodenal hemorrhage operations cases, microsonde is introduced to patient. Before nutrients administration, 1.5 to 2.0 liters of solution containing 1 dose of "Fortrans" preparation to 1 liter boiled water is introduced; infusion rate being 40 to 60 drops during 6 to 8 hours.
EFFECT: reduced early recovery period of motor-evacuation function, increased nutritive maintenance efficiency, postoperative complications and lethality prevention due to early clearing of bowels from hemolysed blood.
2 ex, 2 dwg
FIELD: medicine; pharmacology.
SUBSTANCE: compound for washing of a nasal cavity, nasopharynx and an oral cavity includes salt rock, carnallite, baking soda, a dry extract of dogrose and a dry licorice extract at the following parity of components, wt %: salt rock 70.0; carnallite 25.0; baking soda 2.0; a dry extract of dogrose 1.5; a dry licorice extract - 1.5.
EFFECT: improvement mucous nasopharynxes nutrition and absence of an insoluble deposit.
SUBSTANCE: invention refers to medicine specifically to anaesthesiology and blood-saving techniques in anaesthesiology and resuscitation science, and can be used as anaesthetic management within adrenalectomy caused by epinephros pheochromocytoma. For this purpose operation is preceded with complex patient examination. Preanesthetic medication applied one day before and in the morning prior to operation implies introduction of tableted phenozepam dosed 0.0005-0.001 g, and 30 min before operation sybazone is injected intramuscularly in dosage 10 mg combined with Dimedrol in dose 10 mg. In operating theatre monitoring, puncture and catheterisation of central vein are performed. Then epidural cavity is punctured at height Th7-L1, catheterised so that catheter cap is being placed at height Th5-Th11 to provide following postoperative anaesthesia. Unassisted breathing is accompanied with oxygen inhalation through anaesthesia apparatus mask at rate 5-8 l/minute. Preanaesthetic medication is completed with intravenous bolus dosing of 0.1% atropine solution dosed 0.005-0.007 mg/kg. 5-10 minutes prior to surgical intervention patient blood is exfused in volume 1.0 litres in case arterial pressure is reduced lower than 140/90 mm m.c., and in volume 1.5 litres in case arterial pressure is reduced higher than 140/90 mm m.c. followed by drop-by-drop intravenous introduction of warmed to 37-42°C crystalloid solution either acesol, or trisol, or lactasol or Ringer's solution. Afterwards anaesthesia is added with intravenous bolus dosing to central vein of 2% thiopental sodium solution in dosage 4-5 mg/kg, 0.005% fentanyl solution dosed 0.0025-0.0035 mg/kg followed by intubation of trachea accompanied with precurarisation by introduction of either pipecuronium bromide (arduan) in dosage 1-2 mg or rocuronium bromide (esmerone) in dosage 10-20 mg and against muscular relaxation introduction of 2% suxamethonium iodide solution (dithylinum) in dosage 1.5-2 mg/kg, then patient is transferred to artificial pulmonary ventilation. Within epinephros central vein clipping and crossing for separation of pathologically modified epinephros complete or partial autoblood is reinfused until patient arterial pressure is completely stabilised at level 100-110/60-70 with following infusion crystalloids warmed up to 37-42°C. In case of partial autoblood reinfusion, repeated reinfusion of the rest autoblood volume is performed within the first days of early postoperative period. Anaesthesia management within all stages of surgical intervention is carried under artificial pulmonary ventilation by inhalation of mixed nitrogen monoxide and oxygen at ratio 2:1 to 3:1 using reversive breathing circuit of ventilation respiratory capacity 7-8 ml/kg at minute ventilation 100-120 ml/kg, intravenous introduction of fentanyl dosed 5-6 mkg/kg/h, as well as introduction of arduan in dosage 2-4 mg every 40-60 minutes of operation procedure or introduction of esmerone in dosage 10-20 mg every 25-35 minutes of operation procedure. Anaesthesia is completed at stage of operation termination by termination of intravenous introduction of fentanyl and relaxing agents against continuation of artificial pulmonary ventilation by oxygen-air mix with FiO2 equal to 0.4-0.6. Method provides stabilisation of haemodynamics and cardiac activity during adrenalectomy without vasopressor application.
EFFECT: provided possibility of stabilisation of hemodynamics and cardiac activity during adrenalectomy without vasopressor application.
3 ex, 4 cl
FIELD: medicine, chemical-pharmaceutical industry, pharmacy.
SUBSTANCE: invention relates to cardiosurgery and can be used in operations on heart. Invention proposes a cardioplegic solution for intraoperation protection of myocardium containing the following components, ml: 5% KCl solution, 11-14; 5% NaHCO3 solution, 4-6; 25% MgSO4 solution, 1-2; 15% mannitol solution, 12-15; 40% glucose solution, 0.5-2; 10% calcium gluconate solution, 1-2, and 0.9% NaCl solution up to 100 ml Prepared solution is mixed with autoblood in the ratio 1:4. The claimed invention allows decreasing dose of inotropic support in post-operation period and to reduce possibility of negative results after operation on heart.
EFFECT: valuable medicinal properties of solution.
FIELD: medicine, pharmaceutical.
SUBSTANCE: invention relates to solid composition for treatment of reflux esophagitis, gastritis, or ulcers, method for production thereof and uses in therapy. Claimed composition contains alginate, bicarbonate and/or carbonate, and poly(C1-C5-alkylene glycol) hawing molecular mass of at least 6000 in amount of 1-50 %.
EFFECT: composition of decreased foam-forming properties and improved organoleptic characteristics.
12 cl, 18 ex
SUBSTANCE: invention refers to medicine, namely to oncology, and can be used in therapy of breast cancer with bone metastasis. Substance of the invention consists in puncture with a needle between III and IV lumbar vertebras in subarachnoid spinal marrow space. Cerebrospinal fluid in amount 2 ml is poured in a sterile bottle and added with Epitalamine 10 mg. The bottle is incubated in a thermostat at temperature 37°C within 20 minutes. Then the prepared mixed liquor and Epitalamine are introduced back into subarachnoid space that is combined with introduction of hydrocortisone 125 mg. The therapeutic course includes 4 lumbal punctures with introduction of preparations once a week.
EFFECT: application of the invention provides regress of bone metastases, reduced toxic collateral reactions of hormonotherapy, immune correction ensured by combined endoliquor introduction of said agents.