Hydrogel compositions for dental bleaching

FIELD: medicine.

SUBSTANCE: composition contains water-swelling, water-insoluble polymer, mixed hydrophilic polymer and complementary oligomer able to form hydrogen bond with hydrophilic polymer, and a bleaching agent, preferentially peroxide. The composition is applied a dental bleaching composition and applied on teeth to be bleached, and then removed as the required bleaching is reached. In best versions the composition is unstable and translucent. There are also methods of preparation and application of the compositions.

EFFECT: reduced dental sensitivity and damage or irritation of gums and oral mucous membranes, improved clinical effectiveness.

54 cl, 10 ex

 

The technical field to which the invention relates

The present invention relates generally to compositions hydrogels for care of teeth and more specifically relates to new compositions of hydrogels suitable for use in whitening individuals.

The level of technology

Change the color of teeth are common in society and according to the estimates found in two of the three adults. Change the color of teeth is considered as an aesthetic flaw or defect and may have negative consequences in a person's life, subject to it, causing low self-esteem and even suppressing a smile. Tooth discoloration can be particularly unpleasant or problematic in situations and professions, where demonstration of clean and white teeth is the main.

The tooth consists of an inner dentin layer and an outer hard layer of enamel, which is slightly porous. The outer layer is a protective layer of the tooth. Natural tooth color is white from opaque to translucent or slightly whitish. Staining of teeth occurs as a result of exposure to compounds such as tannins and other polyphenolic compounds on the teeth. These compounds are captured protein layer on the surface of the teeth or get in contact with him and can penetrate the enamel and even in the dentin. Sometimes krasivaya may occur from sources inside the tooth, such as tetracycline, which can be incorporated in the teeth if they are introduced to the individual when he is young.

Surface stains can usually be removed by mechanical cleaning of the teeth. However, the enamel or dentin with changed color does not lend itself to mechanical methods of cleaning the teeth and to remove colouring matter requires chemical methods, which can penetrate into the tooth structure. The most efficient means of processing from the color change of teeth are compositions containing an oxidizer, such as hydrogen peroxide, which is able to interact with chromogenic molecules responsible for the color change, and do them, either colorless or water-soluble, or both.

Therefore, the composition for whitening teeth usually fall into two categories: (1) gels, pastes or liquids, including toothpastes, which are mechanically mixed on the painted surface of the tooth to effect the removal of the staining of teeth by means of abrasive destruction of surface staining; and (2) gels, pastes, or liquids that have a whitening effect on the teeth by means of a chemical process during contact with the painted surface of a tooth within a certain period of time, after which the drug is removed. In some cases, auxiliary Khimich the RCM process which may be oxidative or enzymatic complements the mechanical process.

Some dental compositions, such as cleaning teeth, toothpastes, gels and powders that contain whitening agents, releasing active oxygen or hydrogen peroxide. Such bleaching agents include peroxides, percarbonates and perborates alkali and alkaline earth metals or complex compounds containing hydrogen peroxide. Also, peroxide salts of alkaline or alkaline earth metals is known as suitable for use in whitening teeth.

Many peroxides, affordable professional constituting the composition for whitening teeth, hydrogen peroxide (and its products prepare or associated complexes, such as peroxidation and percarbonate sodium) is used almost without exception. Chemistry of hydrogen peroxide are well known, although the specific nature of its interaction with Chromogens tooth poorly understood. It is assumed that the hydrogen peroxide destroys the Chromogens of the tooth through the oxidation of unsaturated bonds of carbon-carbon, carbon-oxygen and carbon-nitrogen found in the molecules of the coloring substances, thus making them colorless or soluble.

A related class of compounds, peroxyacids, used in detergents for washing, for efficiency the efficient bleaching of fabrics, first of all, because of their stability in solution and their ability to specific binding to certain types of molecules coloring substances. Used a number of stable solid peroxyketal, including depreciationof acid and a magnesium salt monoperoxyphthalic acid. Other peroxyacids, such as peroxidasa acid, are available in the form of solutions containing the equilibrium distribution of acetic acid, hydrogen peroxide, peroxyoctanoic acid and water. Alternative donor peroxide, such as perborate sodium or percarbonate sodium, produces together with the predecessor peroxyacids. Upon contact with water donor peroxide releases hydrogen peroxide, which then interacts with the precursor peroxyacids with the formation of the peroxyacids. Examples of peroxyketal obtained in situ include peroxyoctanoic acid from hydrogen peroxide and tetraacetylethylenediamine) and proxynodename acid from hydrogen peroxide and nonenvironmental sulfonate).

Peroxyacids are also used in compositions for the care of oral hygiene to whiten stained teeth. U.S. patent No. 5279816 describes a method of whitening teeth comprising applying the composition containing peroxyoctanoic acid having an acid pH. European patent 545594 Al describes the usage peroxyoctanoic acid in the preparation of a composition for whitening teeth. Peroxidasa acid may be present in the composition or alternatively can be generated in situ by combining the source of the peroxide with the predecessor peroxyoctanoic acid during use. For example, U.S. patent No. 5302375 describes a composition that generates peroxyoctanoic acid in the medium in situ by combining water, acetylsalicylic acid and water-soluble percarbonate alkali metal.

The most widely used agent for teeth whitening is proximately (CO(NH2)2H2O2), also called peroksigidrat urea, peroksigidrat urea and hydroponic. Proximation used by dentists for several decades as an antiseptic for the mouth, and teeth whitening is a side effect detected at long contact times. Nonprescription composition 10% proximation are available as GLY-OXIDE®from Marion Laboratories, and PROXIGEL®from Reed and Carnrick, they are the compositions of low viscosity, which, to ensure contact with the teeth, must be contained in a tray or similar container. Whitening gel that is able to keep the tray for dental care in a comfortable adjunction in place within prodolzhitelnost the period of time, available under the trade name OPALESCENCE®from Ultradent Products, Inc., South Jordan, Utah.

To these songs were held in place, the composition should be a viscous liquid or gel. The use of trays for dental care also requires that the tray has been adapted for the comfort and convenient connection (junction), so that the tray had no pressure or did not cause irritation of the teeth or gums of the user. Such bleaching compositions must be made so that they were quite sticky and viscous to resist dilution under the action of saliva.

In one of the methods of teeth whitening individual specialist care of your teeth will be invented independently a tray to whiten your teeth on the cast made from the teeth of the patient, and prescribe the use of oxidizing gel, which must be allocated in the tray for whitening and applied at intervals during the period from about 2 weeks to about 6 months, depending on the degree of staining of the teeth. These oxidizing composition, usually Packed in small plastic syringes or tubes, are distributed directly by the patient hand-made tray for whitening teeth, held in place in the mouth during the time of contact, greater than about 60 minutes, and sometimes on the same takes from 8 to 12 hours. Slow speed whitening for the most part is a consequence of the nature of the drugs that are developed to maintain the stability of the oxidizing composition.

For example, U.S. patent No. 6368576, Jensen describes compositions for whitening teeth, which are preferably used together with the tray, so that the composition is held in position near the surfaces of the teeth of the patient who undergoes treatment. These compositions are described as the material of the adhesive matrix formed by combining a sufficient amount of thickening agent, such as an carboxypolymethylene with a solvent, such as glycerine, glycol or water.

In another example, U.S. patent No. 5718886, Pellico describes a composition for whitening teeth in the form of a gel composition containing peroxidation, dispergirovannoyj in anhydrous gelatinases media, which contains a polyol, a thickener, and xanthan gum.

Another example is described in U.S. patent No. 6419905, Hernandez, which describes the use of compositions containing peroxidation (0.3 to 60%), xylitol (from 0.5 to 50%), potassium salt (0.001 to 10%) and salt fluoride (0.15 to 3%), prepared in the form of a gel, which contains between 0.5 and 6 wt.%. appropriate gelling agent.

Composition for whitening teeth, which adheres to the tooth is, described in U.S. patent No. 5989569 and 6045811, Dirksing. In accordance with these patents gel containing 30-85% glycerol or polyethylene glycol, 10-22% complex urea/hydrogen peroxide, 0-12% carboxypolymethylene, 0-1% sodium hydroxide, 0-100% triethanolamine (TEA), 0-40% water, 0-1% flavoring, 0-15% sodium citrate and 0-5% ethylenediaminetetraacetic acid. The preferred gel according to Dirksing has a viscosity in the range between 200 and 1,000,000 CP at low shear rates (less than one 1/second) and is sufficiently adhesive to eliminate the need for the tray.

Currently available compositions for whitening teeth have the significant disadvantage that they cause sensitisation teeth more than 50% of patients. Tooth sensitivity can be caused by movement of fluid through detinova tubes that feels nerve endings in the tooth, due to the presence in these compositions of glycerol, propylene glycol and polyethylene glycol. This can lead to different degrees of tooth sensitivity after teeth contact with heat, cold, too sweet substances and other agents affecting.

Prolonged contact of the teeth with bleaching compositions, as is currently practiced, has a number of negative effects in addition to Chu the reality of the teeth. These negative impacts include the leaching of calcium from the enamel layer at a pH of less than 5.5; penetration of bleaching agents in intact enamel and dentin, and the risk of damage to the pulp tissue; and dilution of the bleaching compositions of saliva, leading to leaching from the tray for care of teeth and subsequent ingestion by the user.

Some oxidizing composition (typically having a relatively high concentration of oxidants) are applied directly to the surface of the patient's teeth in a dental office under the supervision of a dentist or specialist care of teeth. Theoretically, such a strategy of teeth whitening give faster results and better overall patient satisfaction. However, due to the high concentration of oxidants contained in these so-called compositions "Cabinet", they can be dangerous for the patient and the specialist, if you do not observe caution when handling. The soft tissue of the patient (gums, lips and other mucous surfaces) must first be isolated from possible contact with the active oxidant through the use of perforated sheet rubber (known as rubber septum), so that from it are the only teeth. Alternative soft tissue can isolate from oxidizers, the cat is who should be used in the bleaching method, by coating the soft tissue of the polymerized composition, which has a shape matching the contours of the gums, and then cured by exposure to a light source of high intensity. After the soft tissue is isolated and protected, the specialist may cause oxidant directly on the painted surface of the teeth for a specified period of time or until will not occur until sufficient color change of teeth. Typical results obtained through the use of bleach for teeth for study are in the range of about 2 to 3 shades (as measured by the Index of shades VITA, VITA Zahnfarbik).

The range of shades of teeth in the Index of VITA shades varies from very light (B1) to very dark (C4). A total of 16 shades of teeth comprise the full range of colors between these two extreme points on the scale of brightness. The satisfaction of the patient, the procedure of teeth whitening increases with resulting changes shades of teeth, while universally accepted desirable minimum change is approximately 4 to 5 shades VITA.

In relation to products for the care of mouth, teeth whitening is desirable to create products for the care of the oral cavity using an adhesive hydrogel that contains bleach which the tender agent for the removal of coloring matter from the teeth of the individual. Preferred are compositions which do not require the use of dental trays to ensure contact between the bleaching agent and teeth. These products are ideally would cause minimal tooth sensitivity or even would not cause it, drove to minimize or eliminate leakage of the whitening agent, leading to ingestion by the user or result in damage to or irritation of the gums or mucous membranes of the mouth, would provide a longer service life, permanent dissolution agent for whitening teeth, improved efficacy and was well tolerated wouldn patients. It would also be desirable to create a product for the care of mouth, teeth whitening, which is a solid composition is adhesive, but which does not stick to the fingers of the user or which is unstable (for example, is a liquid or gel) and which forms a film when dry. The present invention satisfies these needs.

The invention

One aspect of the present invention relates to compositions containing swelling in water, water-insoluble polymer, a mixture of hydrophilic polymer and a complementary oligomer capable of forming hydrogen bonds or electrostatic ties with hydrophilic what alimera, and whitening agent.

In a preferred embodiment, swelling in water, water-insoluble polymer is an ester of cellulose or polymer, or copolymer based on acrylate; hydrophilic polymer is a poly(N-vinylacetal ), poly(N-vinylamide), poly(N-alkylacrylate) or their copolymer mixture; complementary oligomer capable of the formation of hydrogen bonds with hydrophilic polymer is polyalkyleneglycol or polyalkyleneglycol with carboxyl end groups; and the bleaching agent is a peroxide.

The composition optionally contains a low molecular weight plasticizer, and may also contain at least one additive selected from the group consisting of fillers, preservatives, pH regulators, softeners, thickeners, coloring agents (for example, pigments, dyes, reflective particles, and the like), flavorants (for example, sweeteners, flavors, stabilizers, hardening agents, and agents to reduce stickiness.

In a preferred method of using the composition is a composition for whitening teeth and applied to the teeth that need whitening, and then deleted when it reaches the level of whitening. In certain embodiments of the implementation of the composition to bleach the teeth preservation is translucent, and the composition is removed when the user is satisfied with the level of whitening.

Another aspect of the present invention relates to compositions containing swelling in water, water-insoluble polymer, a mixture of hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with the hydrophilic polymer, and an agent selected from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal and their combinations.

Another aspect of the present invention relates to a method for obtaining a film of hydrogel suitable for inclusion in a composition for whitening teeth. This method involves the preparation of a solution or gel, swelling in water, water-insoluble polymer, a hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds or electrostatic communication with the hydrophilic polymer in the solvent; the deposition of a layer on the substrate to create the coating; and heating the substrate with the coating to a temperature in the range from about 80°C to about 100°C, over a period of time from about 1 to about 4 hours, thereby producing on the substrate a film of hydrogel.

In another method of obtaining a composition for whitening teeth method includes processing in the molten state responsive when the AI through the extruder a mixture of swelling in water, water-insoluble polymer, a hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds or electrostatic communication with the hydrophilic polymer, to form an extruded composition, where the composition is extruded in the form of a film of the desired thickness on the corresponding substrate.

The method further includes loading the film hydrogel bleaching agent, thereby producing a composition for whitening teeth.

Adhesive composition for tooth whitening of the present invention provide several significant advantages compared with the prior art. In particular, these compositions

(1) provide easy manipulation;

(2) is easily modified during production, so it can be controlled and optimized properties such as adhesion, absorption, transparency, and swelling;

(3) can be manufactured in such a way that the viscosity increases or decreases in the presence of moisture, so that the composition is not sticky until moistened;

(4) minimize the leakage of the bleaching agent from the composition in the oral cavity of the user;

(5) can be produced in a translucent form, allowing the user to see the degree of whitening without removal of the composition of the hydrogel with the teeth.

(6) SV is changed to minimize damage to the gums or mucous membranes in the oral cavity;

(7) can be carried comfortably and quietly;

(8) can be easily removed from the teeth and do not leave residues;

(9) provide long toe or effect; and

(10) slow and controlled release of the whitening agent.

Detailed description of the invention

I. Definitions and nomenclature

Before a detailed description of the present invention should be understood that unless otherwise indicated, the present invention is not limited to specific materials, hydrogels, or methods of production, as they may change. It should also be understood that the terminology used in the description, is intended only for the purpose of describing particular embodiments and is not intended to be limiting. It should be noted that, as used in the present description and attached claims, the singular number include the objects in the plural, unless the context clearly dictates otherwise. So, for example, reference to "hydrophilic polymer" includes not only the individual hydrophilic polymer, but also a combination or mixture of two or more different hydrophilic polymers, reference to "plasticizer" includes a combination or mixture of two or more different plasticizers, as well as a separate plasticizer, and the like.

In the description and the formula of the present invention will use the following terminology in accordance with the definitions below.

The definition of "hydrophobic" and "hydrophilic" polymers are based on the amount of water vapor absorbed by the polymer at 100% relative humidity. In accordance with this classification hydrophobic polymers absorb only up to 1% wt. water at 100% relative humidity ("ov"), while moderately hydrophilic polymers absorb 1-10% wt. water, hydrophilic polymers capable of absorbing more than 10% wt. water and hygroscopic polymers absorb more than 20% wt. water. "Swelling in water" polymer is a polymer that absorbs an amount of water greater than at least 25% wt. from its own weight, and preferably at least 50 wt.%. from its own weight when immersed in the aquatic environment.

The term "cross-linked (cross stitched)" refers here to the composition containing intramolecular and/or intermolecular cross-linking that occurs through covalent or non-covalent linkages. "Non-covalent linkage includes education as hydrogen bonds and electrostatic (ionic) bonds.

The term "polymer" includes linear and branched polymer structure and also covers cross stitched polim the market, and copolymers (which may or may not be cross stitched), thus including block copolymers, alternating copolymers, random copolymers, and the like. Compounds referred to here as "oligomers", are polymers having a molecular weight below about 1000 Da, preferably below about 800 Da.

The term "hydrogel" is used in the ordinary sense and refers to swelling in water of the polymer matrix, which can absorb the amount of water, enough to form elastic gels, where the "matrix" is a three-dimensional network of macromolecules held together by covalent or non-covalent cross-links. When placed in an aqueous environment dry hydrogels swell to the extent permissible degree of cross-linking.

The term "composition for tooth whitening" refers to a composition that contains a hydrogel, as here defined, and the whitening agent.

The term "whitening agent"generally refers to an oxidant such as peroxide or chlorite, as will be discussed in more detail below. In some cases, the bleaching agent can be an enzyme or other catalytic tool to remove staining from the teeth. The whitening agent may contain one or more additional Televisa agents, surface-active agents, agents against plaque formation, agents against the formation of dental stones and abrasive agents. The whitening agent may have additional useful therapeutic properties.

The term "stickiness" and "sticky" are qualitative. However, the term "essentially non-sticky", "slightly sticky" and "sticky", as used here, can be determined quantitatively using values obtained in the method of determining the stickiness PKI or TRBT, as outlined further. The term "essentially non-sticky" refers to the composition of the hydrogel, which has a value of stickiness, which is less than about 25 g-cm/sec, under "slightly sticky" refers to the composition of the hydrogel, which has a value of stickiness in the range from about 25 g-cm/sec to about 100 g-cm/sec, and under the "sticky" refers to the composition of the hydrogel, which has a value of stickiness at least 100 g-cm/sec.

The term "water-insoluble" refers to a compound or composition whose solubility in water is less than 5 wt.%, preferably less than 3 wt.%, more preferably less than 1 wt.%. (measured in water at 20°C).

The term "translucent" is used here to denote a material that can transmit light, so that the object or image can be seen through the material. Polypros acnee materials here may or may not be "transparent" in the sense what material is optically transparent. The term "translucent" means that the material is not "opaque", in this case, the image objects may not be visible through the material.

II. Composition

The composition according to the present invention consists of swelling in water, water-insoluble polymer, a mixture of hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with the hydrophilic polymer, and a bleaching agent. Swelling in water, water-insoluble polymer, i.e. the polymer, which is able to swell when immersed in liquid water, but is insoluble in water at the selected pH range (typically less than pH 5.5), is an ester of cellulose or polymer or copolymer of acrylate-based, that is, a polymer or copolymer of acrylic acid or of ester of acrylic acid ("acrylate polymer). The polymer typically swells at least 25% wt., and preferably at least 50 wt.%, from its own weight when immersed in water or an aqueous solution. In some embodiments, implementation, use certain hydrophilic polymers, the composition may swell even at 1400% wt. from its dry mass.

The composition preferably is a composition for whitening teeth, where function is a bleaching agent used for whitening a tooth surface, coated composition. However, the whitening agent may have other applications, for example, as a therapeutic agent or other type of cosmetic agent, for example, for skin lightening. For this reason, the compositions described herein may find use as pharmaceutical compositions for application to a body surface (e.g., teeth, nails, skin, mucous membranes, and the like) for the treatment of painful conditions. For example, hydrogen peroxide also has antibiotic properties and medicines against acne, along with the fact that it is a bleaching agent. For this reason, the present invention also involves the treatment of infection or pimples by applying compositions of the present invention, hydrogen peroxide, on the surface of the body. Other painful conditions include, as an illustration, but not limitation, fungal infections, acne, wounds, skin lightening, and so on.

The hydrophilic polymer is, as a rule, relatively high molecular weight polymer and a complementary oligomer is generally more low molecular weight polymer. For solid compositions swelling in water, water-insoluble polymer comprises about 1-20 wt.%, preferably, about 6-12% by weight. from the composition; hydrofil the first polymer is about 20-80 wt.%, preferably, about 40-60 wt.%. from the composition; the complementary oligomer is about 10-50 wt.%, preferably, about 15-35% by weight. from the composition; and the whitening agent is about 0.1-60 wt.%, preferably, about 1-30 wt.%. from the composition. Optimally complementary oligomer is about 10-80 wt.%, preferably about 20-50% by weight. from the mixture of the hydrophilic polymer/complementary oligomer.

In some cases, complementary oligomer may also serve as a low molecular weight plasticizer. Alternative another connection may be included as an additional low molecular weight plasticizer and if it is, it would be approximately 30-35% wt. from the composition.

For non-solid compositions of swelling in water, water-insoluble polymer is about 0.1-40 wt.%, preferably, about 0.1-20 wt.%, more preferably, about 2-6 wt.%, from the composition; the hydrophilic polymer is about 0.1-20 wt.%, preferably, about 1-20 wt.%, more preferably, about 4-10 wt.%, from the composition; the complementary oligomer is about 0.05 to 20 wt.%, preferably, about 0.1-20 wt.%, more preferably, about 0.5-10 wt.%, from the composition; and the whitening agent is about 0.1-60 wt.%, preferably, about 1-40 wt.%, from what oppozitsii. Optimally complementary oligomer is about 1-85% wt., preferably, about 5-50 wt.%, from the mixture of the hydrophilic polymer/complementary oligomer.

The profile of adhesion can be constructed based on the type of polymer, composite relationships and the level of water in the mixture. Swelling in water, water-insoluble polymer is selected in such a way as to provide a desired profile of adhesion with respect to hydrating. That is, when swelling in water, water-insoluble polymer is an ester of cellulose, the composition typically is sticky to contact with water (e.g. with a wet surface), but gradually loses its stickiness, when the composition absorbs moisture. When swelling in water, water-insoluble polymer is an acrylate polymer or copolymer, a composition, which, as a rule, is essentially non-sticky to contact with water, but becomes sticky upon contact with a wet surface.

Swelling in water, water-insoluble polymer capable of at least some degree of swelling when immersed in liquid water, but is insoluble in water. The polymer may consist of a complex of cellulose ether, for example, acetate cellulose, acetate cellulose propionate (CAP), acetate butyrate cellulose (CAB), cellulose propionate (CP), the bout is rata cellulose (CB), propionate of butyrate cellulose (CPB), cellulose diacetate (CDA), cellulose triacetate (CTA) or the like. These esters of cellulose are described in U.S. patents№№ 1698049, 1683347, 1880808, 1880560, 1984147, 2129052 and 3617201 and can be obtained by using techniques known in the field, or can be obtained commercially. Commercially available esters of cellulose suitable for use in the description, include CA 320, CA 398, CAB 381, CAB 551, CAB 553, CAP 482, CAP 504, they are all available from Eastman Chemical Company, Kingsport, Tenn. Such esters of cellulose, as a rule, have srednekamennogo molecular weight in the range between about 10,000 and about 75000.

As a rule, complex cellulose ether comprises a mixture of cellulose and Monomeric units of ester of cellulose, for example commercially available acetate butyrate cellulose contains monomer units of the cellulose acetate, and monomer units of the cellulose butyrate and monomer units neeterificirovannah cellulose, while acetate propionate cellulose contains such monomer units as cellulose propionate. In the invention, the preferred esters of cellulose are the compositions of acetate propionate cellulose and composition acetate butyrate cellulose, having a content of butyryl-, propionyl, acetyl - and neeterificirovannah (OH) cellulose, as follows:/p>

Acetyl
(%)
OH
(%)
MW
(g/mol)
Tg
(C)
Tm
(C)
Acetate butyrate cellulose17-52%
butyrate
a 2.0
29,5
1,1-
4,8
12000-
70000
96-
141
130-
240
Acetate propionate, cellulose42,5-47,7%
propionate
0.6 to
1,5
1,7-
5,0
15000-
75000
142-
159
188-
210

Also specify the preferred molecular weight, the glass transition temperature (Tg) and melting temperature (Tm). Also suitable for use as cellulosic polymers typically have an internal viscosity (I.V.) of from about 0.2 to about 3.0 deciliter/gram, preferably from about 1 to about 1.6 deciliter/gram as measured at 25°C for the sample of 0.5 grams per 100 ml of phenol/tetrachlorethane, 60/40 by mass is. When it is produced using the technology of casting from a solution, swelling in water, water-insoluble polymer should be selected to ensure greater cohesion and, thus, facilitate the formation of a film (in General, for example, acetate propionate, cellulose tends to improve the adhesion forces to a much greater extent than acetate butyrate cellulose).

Other preferred swelling in water, the polymers are acrylate polymers, typically derived from acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, and/or other vinyl monomers. Suitable for use acrylic polymers are copolymers available under the trade name "Eudragit" from Rohm Pharma (Germany). Copolymers Eudragit series E, L, S, RL, RS and NE are available solubilizing in an organic solvent, in aqueous dispersion or in the form of a dry powder. Preferred acrylic polymers are copolymers of methacrylic acid and methyl methacrylate, such as polymers of series Eudragit L and Eudragit S. Particularly preferably such copolymers are Eudragit L-30D-55 and Eudragit L-100-55 (the latter copolymer is a obtained by spray drying the form of Eudragit L-30D-55, which may be diluted with water), and Eudragit RS 100. Molecular the ACCA copolymer Eudragit L-30D-55 and Eudragit L-l00-55 is approximately 135000 Yes, with the ratio of free carboxyl groups to ester groups is approximately 1:1. The copolymer generally is insoluble in aqueous fluids having a pH below 5.5. Another particularly suitable for use copolymer of methacrylic acid-methyl methacrylate is a Eudragit S-100, which differs from Eudragit L-30D-55 the fact that the ratio of free carboxyl groups to ester groups is approximately 1:2. Eudragit S-100 is insoluble at pH below 5.5, but, unlike Eudragit L-30D-55, is poorly soluble in aqueous fluids having a pH ranging from 5.5 to 7.0. This copolymer is soluble at pH 7.0 and above. Can also be used Eudragit L-l00, which has a pH-dependent solubility profile, intermediate between Eudragit L-30D-55 and Eudragit S-100, since it is insoluble at pH below 6.0. Specialists in this field will notice that Eudragit L-30D-55, L-100-55, L-100 and S-100 can be replaced by other acceptable polymers having similar pH-dependent solubility characteristics. Other usable acrylate polymers are copolymers of methacrylic acid/ethyl acrylate available under the trade name Kollicoat" from BASF AG (Germany). For example, Kollicoat MAE has the same molecular structure as Eudragit L-100-55.

When the swelling in water of the polymer represents what OLIMAR acrylic acid or acrylate polymer, creates a hydrogel, which can dry reversible, i.e. after removal of water and any other solvents dried hydrogel may be restored to its original state by adding water. In addition, hydrophilic hydrogels prepared with the help of swelling in water of the polymer of acrylic acid/acrylate, as a rule, are essentially non-sticky to contact with water, but become tacky upon contact with a moist surface, such as a surface in the oral cavity, such as teeth. This property to be non-sticky to contact with water allows for placement or re-placement on the selected surface, before the hydrogel becomes sticky or during this. After hydrating the hydrogel becomes sticky and adheres to the tooth surface.

In addition, compositions containing acrylate may, as a rule, to ensure the swelling in the range of about 400-1500% when immersed composition of the hydrogel in water or other aqueous liquid at a pH of less than 5.5, although the ratio of acrylic polymer to the mixture of the hydrophilic polymer/complementary oligomer can be selected so that the rate and extent of swelling in the aquatic environment had given the dependence on pH. This feature also provides retroactive is the inclusion of bleaching agents or other agents, such as load composition peroxide, peroxynitrate, chlorite, stabilizers, flavorants and the like.

In contrast, the inclusion complex of cellulose ether as a swelling in water of the polymer makes the hydrogel adhesive to be applied on a wet surface, but non-sticky when absorbed in water. It will be understood that this arrangement may be desirable when reducing the stickiness is desired for the end product removal from the teeth.

The second component of the hydrogel composition is a mixture of hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with hydrophilic polymer and optionally able also to the formation of ionic or covalent bonds with the hydrophilic polymer. Suitable for use hydrophilic polymers include repeating units derived from the monomer N-vinylacetate, monomer carboxyvinyl, monomer of vinyl ester, a monomer complex carboxyvinyl ether monomer vinylamide and/or monomer hydroxyphenyl. Such polymers include, as an example, poly(N-vinylacetate), poly(N-vinylacetate), poly(N-alkylacrylate), polymers of substituted and unsubstituted acrylic and methacrylic acid (for example, polyacrylic acid and polymethacrylic acid), watering niloy alcohol (PVA), polyvinyliden, their copolymers and copolymers with other types of hydrophilic monomers (e.g. vinyl acetate).

Poly(N-vinylacetate), suitable for use in the invention preferably are not sewn transversely of the homopolymers or copolymers of monomer units of N-vinylacetate, with monomer units of N-vinylacetate constitute the main part of all monomer units of the copolymer poly(N-vinylacetate). Preferred poly(N-vinylacetate) for use in combination with the present invention receive by polymerization of one or more of the following monomers N-vinylacetate: N-vinyl-2-pyrrolidone; N-vinyl-2-valerolactam; and N-vinyl-2-caprolactam. Non-limiting examples of comonomers other than N-vinylacetate suitable for use in combination with monomer units of N-vinylacetate include N,N-dimethylacrylamide, acrylic acid, methacrylic acid, hydroxyethylmethacrylate, acrylamide, 2-acrylamide-2-methyl-1-propanesulfonic acid or its salt and vinyl acetate.

Poly(N-alkylacrylate) include, as an example, poly(methacrylamide) and poly(N-izopropilakrilamid) (PNIPAM).

Polymers carboxyvinyl monomers, usually derived from acrylic acid, methacrylic acid, crotonic acid, isocrotonic acid, basis of itaconic acid and is midride, 1,2-dicarboxylic acid such as maleic acid or fumaric acid, maleic anhydride or mixtures thereof, with the preferred hydrophilic polymers in this class include polyacrylic acid and polymethacrylic acid, with acrylic acid is most preferred.

Preferred hydrophilic polymers are the following: poly(N-vinylacetate), in particular, polyvinylpyrrolidone (PVP) and polyvinylcaprolactam (PVCap); poly(N-vinylacetate), especially polyacetate; polymers of carboxyvinyl monomers, especially polyacrylic acid and polymethacrylic acid, and their copolymers and mixtures. PVP and PVCap are particularly preferred.

The molecular mass of the hydrophilic polymer is not critical; however, srednekislye molecular weight hydrophilic polymer is generally in the range of about 100000-2000000, more preferably, within about 500000-1500000. The oligomer is "complementary" to hydrophilic polymers in that it is capable of forming hydrogen bonds with them. Preferably complementary oligomer has a terminal hydroxyl group, amino or carboxyl group. The oligomer typically has a glass transition temperature Tgin the range from about -100°C to about -30°C and the temperature is at the melting point T mlower than about 20°C. the Oligomer may also be amorphous. The difference between the values of Tgthe hydrophilic polymer and the oligomer is preferably greater than about 50°C, more preferably, greater than about 100°C, and most preferably is in the range from about 150°C to about 300°C. Hydrophilic polymer and a complementary oligomer must be compatible, that is capable of forming a homogeneous mixture, which demonstrates one of Tgintermediate between the temperatures of the unmixed components.

Typically, the complementary oligomer will have a molecular weight in the range from about 45 to about 800, preferably from about 45 to about 600. The complementary oligomer is preferably a low-molecular polyalkyleneglycol (molecular weight of 300-600), such as polyethylene glycol 400, which may also serve as a low molecular weight plasticizer. Alternative as an additional low molecular weight plasticizer may include another connection in this case may be any of low molecular weight plasticizers described below. In one of the embodiments of the present invention, the complementary oligomer is a low-molecular complementary or olig the dimensional plasticizer, which contains at least two functional groups per molecule that are capable of forming hydrogen bonds with the hydrophilic polymer.

Examples suitable for use complementary oligomers include, but are not limited to, low molecular weight polyalcohol (e.g., glycerol), Monomeric and oligomeric alkalophile, such as ethylene glycol and propylene glycol, ether alcohols (for example, a simple glycol ethers), dibasic carbonic acid, arcangioli, butanediol to octandiol, including derivatives of polyalkylene glycols with carboxyl and aminobenzamide groups. The polyalkylene glycols, optional with terminal carboxyl groups are preferred, and polyethylene glycol having a molecular weight in the range of about 300-600 is optimal complementary oligomer.

From the above it will be clear that the same connection, for example low-molecular polyalkyleneglycol, such as polyethylene glycol having a molecular weight in the range of about 300-600, can serve as a complementary oligomer, or low molecular weight plasticizer.

As described in the publication of patent No. 2002/0037977 "Preparation of Hydrophilic Pressure Sensitive Adhesives Having Optimized Adhesive Properties, the ratio of hydrophilic polymer and a complementary oligomer is in the above mixtures : effect of adhesion force, and traction force. As described in the above patent application, the complementary oligomer reduces the glass transition temperature of the mixture of the hydrophilic polymer/complementary oligomer to a much greater extent than was predicted by the equation Fox, which is given by the expression (1)

whereTgpredictedrepresents the predicted glass transition temperature of the mixture of the hydrophilic polymer/complementary oligomer,Wpolrepresents the mass fraction of the hydrophilic polymer in the mixture,Wplrepresents the mass fraction of complementary oligomer in the mixture,Tg polrepresents the glass transition temperature of the hydrophilic polymer, andTg plrepresents the glass transition temperature of complementary oligomer. As also explained in this patent application, the adhesive composition having an optimized force of adhesion and bond strength, can be prepared from a hydrophilic polymer and a complementary oligomer by selecting the components and their relative amounts, for a given deviation from theTg predicted. As a rule, to maximize adhesion, a given deviation from theTgpredictedwill be a maximum negative deviation, while for St is Denia adhesion to minimize any negative deviation from the Tg predictedis reduced to a minimum.

When the complementary oligomer may act as a plasticizer, the inclusion of additional plasticizer, as a rule, is not necessary. However, the inclusion of additional low molecular weight plasticizer in the composition is optional and may, in some cases, be beneficial. Suitable for use with low molecular weight plasticizers include diallylphthalate, dicyclohexylamine, Directorate and mixed alkylacrylate submitted by dimethylphthalate, diethylphthalate, dipropylamino, di(2-ethylhexyl)phthalate, diisopropylamino, tamilfilm and dicaprylate; alkyl and arylphosphate, such as tributyl phosphate, trioctylphosphine, tricresylphosphate and triphenyl; complex alkylsilane and citrate esters such as triethylcitrate, triethylcitrate, tributyltin, acetyl triethylcitrate and tryexecute; dialkyldimethyl, such as dioctyladipate (DOA); also referred to as bis(2-ethylhexyl)adipate), diethylacetal, di(2-methylethyl)adipate, and disaccredit; dialkylated, such as diethyltartrate and dibutylated; diallylmalonate, such as diethylsilane, dipropylamine and dionysiaca; dialkylamines, such as diethylamine and dibutylamine; alkylphenolate, alkylglycerols, esters CH the ruts and esters of glycerol, such as glyceraldehyde, glyceroltrinitrate (triacetin), glycerol monolectic diacetate, methyl phthalyl ethylglycol, butyl phthalyl butylglycol, ethylene glycol diacetate, ethylene glycol dibutyrate, triethylene glycol diacetate, triethylene glycol dibutyrate and triethylene glycol dipropionate; and mixtures thereof. Preferred low molecular weight plasticizers for continuous hydrophilic phase are triethylcitrate, diethylphthalate and dioctyladipate, with dioctyladipate is the most preferred.

The properties of the composition according to the present invention is easily controlled by setting one or more parameters during cooking. For example, the adhesion strength of the composition can be monitored during production to increase, reduce or eliminate adhesion. This can be done by changing the type and/or quantity of the various components, or by changing the mode of preparation. Also, regarding the method of preparation, compositions prepared using conventional extrusion from the melt, typically, though not necessarily, are a little less sticky than compositions prepared using casting technology from the solution. In addition, the degree to which the composition of the hydrogel will swell upon contact with water, can sonatica by selecting different swelling in water of the polymers and compositions containing a continuous hydrophilic phase, by establishing relationships swelling in water, water-insoluble polymer to the mixture of the hydrophilic polymer/complementary plasticizer. These compositions may vary in appearance from clear, transparent to translucent and opaque. In addition, certain compositions can be made translucent by changing the relative amounts of components in the hydrophilic phase (for example, by reducing the number of complex cellulose ether), or by changing the cooking method (semi-transparent hydrogels easier obtained using casting from a solution instead of extrusion from the melt). Thus, the translucent composition allows the user to monitor the bleaching process when it is carried out, and to determine when the teeth will be bleached.

The above-described hydrogel composition containing a bleaching agent and therefore act as a delivery system, when applied to the teeth. Releasing bleaching agents, "loaded" in the present composition of the hydrogels, as a rule, include both water absorption and the release agent through the mechanism of diffusion-controlled swelling. Composition of hydrogels containing bleaching agents can be used, for example, in a manner similar to pharmaceutical drugs local injection.

Suitable agents for teeth whitening include peroxides, metal chlorites, perborates, percarbonates, peroxyacids and their combinations. Usable compounds peroxides include hydrogen peroxide, calcium peroxide, proximately and mixtures thereof. The preferred peroxides are hydrogen peroxide and proximately. Other suitable peroxides include organic peroxides, including, but not limited to, dialkylamide, such as tert-butylperoxide and 2,2 bis(tert-BUTYLPEROXY)propane, diazepamonline, such as benzoyl peroxide and acetyl peroxide, complex periphery, such as tert-butylperbenzoate and tert-Builder-2-ethylhexanoate, pentaborate, such as dicetylperoxydicarbonate and dicyclohexylperoxydicarbonate, cloperastine, such as cyclohexanediamine and methylethylketone, and hydroperoxides, such as cumonherface and tert-butylhydroperoxide. The whitening agent is preferably a peroxide such as hydrogen peroxide or peroxidation, and most preferably represents hydrogen peroxide.

Suitable for use chlorides of metals include chlorite calcium, barium chlorite, is lorit magnesium, the lithium chlorite, sodium chlorite and potassium chlorite; hypochlorite and chlorine dioxide. Preferred chlorite is a sodium chlorite.

III. Optional additives

The composition may also include any pharmaceutically active agent, suitable for use in the treatment of physiological conditions related to the teeth and surrounding tissues. As used in the description, "pharmaceutically active agent" is any substance that may be released from the composition for the treatment of undesirable physiological condition. Undesirable physiological condition related to the teeth or surrounding tissues, which are treatable with the help of this tool include helicos; periodontal and oral infections; periodontal damage; caries or tooth decay gingivitis and other periodontal diseases.

Pharmaceutically active agent can represent, for example, non-steroidal anti-inflammatory agent or analgesic; steroid anti-inflammatory agents; local anesthetics; bactericides/disinfectants; antibiotics; antifungal agents; agents to reduce the sensitivity of teeth; fluoride agents against dental caries/tooth decay; agents against Tartar/calculus; the enzymes that inhibit the formation is of LASEK, concrement or decay; abrasive agents, such as pyrophosphates; chelating agents for metals such as Terentieva salt of ethylenediaminetetraacetic acid; antioxidants, such as bottled hydroxyanisol; bottled hydroxytoluene; nutritional additives for local delivery to the teeth and surrounding tissues; and so on.

Suitable for use nonsteroidal anti-inflammatory/analgesic agents include acetaminophen; methyl salicylate; nonagricultural; aspirin; mefenamico acid; flufenamic acid; indomethacin; diclofenac; alclofenac; diclofenac sodium; ibuprofen; flurbiprofen; Frantisek; bufexamac; piroxicam; phenylbutazone; oxyphenbutazone; Clifton; pentazocine; Marisol and tiaramide hydrochloride.

Suitable for use steroid anti-inflammatory agents include hydrocortisone; prednisolone; dexamethasone; triaminobenzene; ftorhinolonami; hydrocortisone; prednisolone acetate; methylprednisolone; dexamethasone; betamethasone; betamethasone; flumetazon; formation; budesonide; and beclomethasone.

Suitable for the use of local anesthetics include debuginstall; dibucaine; lidocaineydrocortisone; lidocaine; benzocaine; hydrochloride complex of 2-(diethylamino)ethyl ester is p-butylaminoethyl acid; procaine hydrochloride; tetrakaidecahedral; chlorpromazinezapomnit; occupationrelated; mepivacain; cocainerelated; and paperikemikaalit.

Suitable for use bactericides/disinfectants include thimerosal; phenol; thymol; benzylaniline; benzotrichloride; chlorhexidine; providentia; cetylpyridinium; eugenol and ammonium bromide.

Suitable antibiotics include penicillin; methicillin; oxacillin; cefalotin; tsefaloridin; erythromycin; lincomycin; tetracycline; chlortetracycline; oxytetracycline; metatsiklina; chloramphenicol; kanamycin; streptomycin; gentamicin; bacitracin and cycloserine.

Suitable for use antifungal drugs include amphotericin; clotrimazole; econazole nitrate; fluconazole; griseofulvin; Itraconazole; ketoconazole; miconazole; nystatin; terbinafine hydrochloride; undecanoyl acid and zinc undecenoate.

Suitable for use agents to reduce tooth sensitivity include potassium nitrate and strontium chloride.

Suitable for use fluoride agents against dental caries/tooth decay include sodium fluoride, potassium fluoride and ammonium fluoride.

Additional whitening agents include agents against Tartar/calculus including the phosphates, such as pyrophosphates, polyphosphates, polyphosphonates (for example, ethane-1-hydroxy-1,1-diphosphonate, 1-azacycloheptane-1,1-diphosphonate and linear alkyl diphosphonates) and their salts; linear carboxylic acid; and sodium zinc citrate; and mixtures thereof. Preferred pyrophosphate salts are dibasic pyrophosphate metal salts, chetyrehskatnye pyrophosphate metal salts; and hydrated or non hydrated form of dinitrodiphenylamine (Na2H2P2O7), tetrahydrofolate (Na4P2O7and tetrakaidecahedral (K4P2O7). Pyrophosphate salts are described in more detail in Kirk &Othmer, Encyclopedia of Clinical Technology, Third Edition, Volume 17, Wiley-Interscience Publishers (1982). Optional bleaching agents also include agents, dissolving dental calculus, such as betaines, amine oxides and Quaternary amines as described in U.S. patent No. 6315991, Zofchak.

Enzymatic agents that can act to inhibit the formation of plaque, calculus or dental caries, also would be useful in the compositions. Enzymatic agents may be stored together with a bleaching agent or they can be located in another layer inside the multilayer system, as the description describes. Suitable enzymes include proteases, which break down proteins, Slu is s, which are absorbed on the surface of the tooth and form a film or the first layer plaques; lipase, which destroy bacteria, lysira proteins and lipids, which form a structural component of the walls and membranes of bacterial cells; dextranase, glucanohydrolase, endoglycosidase and mucinase, which destroy the skeletal structure of bacteria, which forms the matrix for bacterial adhesion to the tooth; and amylase, which prevent the development of stones through the destruction of the complex carbohydrate-protein that binds calcium. Preferred enzymes include any of the commercially available proteases; dextrans; glucanohydrolase; endoglycosidase; amylases; Atanas; lipases; Mucins and compatible mixtures. In some embodiments, the implementation can be used enzymatic bleaching agent.

Optional enzymatic bleaching agent is a peroxidase, so that peroxide is generated in situ. When the enzymatic agent for bleaching or agent against plaque formation is included in the composition, the composition should be such that the enzyme was maintained in its active form, for example, the pH should be approximately neutral, and peroxide may be missing or contained in a separate layer.

Appropriate nutritional supplements for local delivery to the teeth and surrounding the m tissues include vitamins (e.g., vitamins C and D, thiamine, Riboflavin, calcium Pantothenate, Niacin, folic acid, nicotinamide, pyridoxin, cyanocobalamin, para-aminobenzoic acid and bioflavonoids); and minerals (e.g. calcium, phosphorus, fluoride, zinc, manganese and potassium and mixtures thereof. Vitamins and minerals suitable for use in the present invention, described in Drug Facts and Comparisons (service information on separate sheets), Wolters Kluer Company, St. Louis, Mo., 1997, pp 3-17.

The composition may also contain any cosmetically active agent. As used here, "cosmetically active agent" includes any substance that may be released from the composition for implementing the desired change in the appearance of the teeth or surrounding tissues, or which gives the user a socially desirable characteristic, such as fresh breath. For example, the cosmetically active agent can be a breath freshener or agent who performs the whitening or bleaching teeth. Taking into account that in some cultures or in certain segments of Western society staining of the teeth may be significant or desirable, cosmetically active agent may be any agent that imparts a color or shade of the teeth.

The composition may include additional whitening agents. For example, the e can be surfactants, such as detergents, and they will work together with bleaching agent, described above, to give a more striking appearance to the teeth.

In any of these embodiments, the composition for tooth whitening according to the present invention preferably contains peroxide for teeth whitening, and may also contain conventional additives such as fillers, preservatives, pH regulators, softeners, thickeners, colorants, pigments, dyes, reflective particles, stabilizers, hardening agents, pharmaceutical agents, flavorant or agents to freshen breath and amplifiers permeability. In those versions of the implementation, where the adhesion should be reduced or excluded, can also be used in conventional agents to reduce stickiness. These additives and their amounts are selected so that they had no significant negative impact on the desired chemical and physical properties of the composition for whitening teeth or had no effect on the delivery agent for whitening the teeth and they can be included in the composition. Such additional ingredients include coloring compounds; food additives; flavorant; sweeteners and preservatives.

Can be any natural or synthetic flavorant or food additive such as those described which are in Chemicals Used in Food Processing, Pub. No. 1274, National Academy of Sciences, pages 63-258. Suitable for use flavorant include Wintergreen, pepper mint, spearmint, menthol, fruit flavors, vanilla, cinnamon, spices, flavored oils and olomola, as is well known in this field, as well as their combination. The number flavorant usually chosen arbitrarily, depending on such factors as the type flavorant, individual flavorant and desired power. Preferably the composition comprises from about 0.1% wt. to about 5% wt. flavorant.

Sweeteners suitable for use in the present invention include sucrose, fructose, aspartame, xylitol and saccharin. Preferably the composition contains sweeteners in an amount of from about 0,001% wt. to about 5.0 percent by weight.

Suitable for use substrate may be translucent, so that the composition was unnoticeable when worn. However, optionally, the substrate or the composition can be dyed, so that the composition was noticeable when worn. Preferably, if it is desirable colouring, colouring must be present in the substrate. For example, the substrate may be dyed bright or vibrant colors that the user can find pleasant. For this reason, the substrate may contain a coloring compound, such as dye, pigment and the substance, which can impart color when added to a material forming the substrate.

For example, a dye compound of the type commonly used with food, drugs or cosmetics, in connection with the human body, in particular for dyeing substrates can be used color additives permitted for use in food products, which are classified as "certified" or "exempt from certification". Coloring compounds used for the coloration of the substrate, can be obtained from natural sources such as plants, minerals or animals, or may be a synthetic analogues of natural compounds.

Coloring compounds, currently certified under the Food Drug &Cosmetic Act for use in food products and medicines for internal use, include such dyes like FD&C Red No. 3 (sodium salt of tetraiodofluorescein); Food Red 17 (disodium salt of 6-hydroxy-5-{(2-methoxy-5-methyl-4-sulfophenyl)azo}-2-naphtalenesulfonic acid); Food Yellow 13 (sodium salt of a mixture of mono - and disulfonic acid chieftan or 2-(2-chinolin)indandion); FD&C Yellow No. 5 (sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazol-3-carboxylic acid; FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphthol--monosulfonated); FD&C Green No. 3 (disodium salt of 4-{[4-(N-ethyl-p-sulfanilamide)phenyl]-(4-hydroxy-2-sulfanilyl)methylene}-[1-(N-ethyl-N-p-sulfobutyl)for 3,5-cyclohexadiene]); FD&C Blue No. 1 (disodium salt anhydrite dibenzyldithiocarbamate acid); FD&C Blue No. 2 (sodium salt disulfonic acid indigotine); FD&C Red No. 40; Orange B; and Citrus Red No. 2; and combinations thereof in various proportions.

Coloring compounds, exempt from certification FDA, include extract of annatto; beta-APO-8'-carotenal; beta-carotene; beet powder; canthaxanthin; caramel dye; carrot oil; extract of cochineal (Carmine); toasted, partially-fat, cooked cottonseed flour; gluconate iron; fruit juice; grape dye; grape skin extract (enocyanin); paprika; olomola paprika; Riboflavin; saffron; turmeric; olomola turmeric; vegetable juice and combinations thereof in various proportions.

Form a dye compound for use in the composition preferably includes an additive forming dyes, but may also contain lacquer forms that are compatible with the material constituting the substrate. Water-soluble dyes that are supplied in the form of powders, granules, liquids or other special purpose forms can be used in accordance with present the m way. Preferred lacquer or water-insoluble form of the dye used for staining of the substrate. For example, if you want to use suspension of coloring compounds can be used Supplement in the form of a varnish. Suitable for use with water-insoluble coloring varnishes manufactured by increasing calcium or aluminum salts of dyes, FD&C using aluminum oxide include lacquer, FD&C Green #1, lacquer, FD&C Blue #2, Lac FD&C R&D #30 and Lac FD&C # Yellow 15.

Other usable coloring compounds include non-toxic, water-insoluble inorganic pigments such as titanium dioxide; green chromium oxides, ultramarine blue and pink; and iron oxides. Such pigments preferably have a particle size in the range from about 5 to about 1000 microns, more preferably from about 250 to about 500 microns.

The concentration of the dye compound in the substrate is preferably from approximately 0.05% wt. up to about 10 wt.%, and more preferably from about 0.1% wt. to about 5% wt.

The substrate can be more than one dye compounds, so she was given a variety of colors. This set of colors may be in the form of stripes, dots, swirls or any other design that the consumer can find Priya is poor. Coloring the connection may also be used together with other substances, which improves the appearance, such as glittering particles.

When the adhesive is on the surface of the tooth, preferably may include absorbing fillers to control the degree of hydration. Such fillers may include microcrystalline cellulose, talc, lactose, kaolin, mannitol, colloidal silicon dioxide, aluminum oxide, zinc oxide, titanium oxide, salicylate magnesium, magnesium aluminum silicate, hydrophobic starch, calcium sulfate, calcium stearate, calcium phosphate, phosphate dihydrate calcium, clay, such as laponite, woven and non-woven materials made of paper and cotton. Other suitable fillers are inert, that is essentially non-absorbent, and include, for example, polyethylene, polypropylene, copolymers of polyurethane and polyetherimide, pelistry and copolymers of polyester, nylon and rayon. The preferred filler is a colloidal silicon dioxide, for example, Cab-O-Sil® (Cabot Corporation, Boston MA).

Preservatives include, as an example, p-chloro-m-cresol, phenethyl alcohol, phenoxyethylamine alcohol, chlorobutanol, methyl ester of 4-hydroxybenzoic acid, complex propyl ester of 4-hydroxybenzoic acid, benzalconi chloride, caterpie is ini chloride, chlorhexidine diacetate or gluconate, ethanol and propylene glycol.

Compounds suitable for use as pH regulators include, but are not limited to, glycerol buffers, citrate buffers, borate buffers, phosphate buffers, or phosphate buffers with citric acid can also be included in order to ensure that the pH of the hydrogel composition was compatible with the pH of the environment of the oral cavity and not videlacele minerals from the tooth surface. To optimize the bleaching without demineralization of the teeth in the composition may include calcium and/or fluoride salts.

Suitable softeners include esters of citric acid such as triethylcitrate or acetyl triethylcitrate, esters of tartaric acid, such as dibutylated, complex glycerol esters such as glycerol diacetate and glycerol triacetate; esters of phthalic acid such as dibutyl phthalate and diethylphthalate; and/or hydrophilic surfactants, preferably, the hydrophilic non-ionic surfactants, such as partial esters of sugars and of fatty acids, esters of polyethylene glycol and of fatty acids, ethers of polyethylene glycol and of fatty alcohols, and complex esters sorbitane of polyethylene glycol and fatty acids.

predpochtitelnye thickeners are natural compounds or derivatives thereof and include, as an example, collagen; galactomannan; starches; derivatives and hydrolysates of starch; cellulose derivatives such as methylcellulose, hydroxypropylcellulose, hydroxyethyl cellulose and hypromellose; colloidal silicic acid; and sugars such as lactose, sucrose, fructose and glucose. Can also be used synthetic thickeners such as polyvinyl alcohol, copolymers of vinylpyrrolidone-vinyl acetate, polyethylene glycols and polypropylenglycol.

The substrate can also be embedded, or decorate, decorative products, such as bulbs, lenses, or anything like that because these products do not have a negative effect on the viscoelastic properties of the substrate required for the corresponding deformation of the composition on the teeth, as described above. The substrate may also represent letters, words, or images created for fun or attractive to the consumer.

IV. The manufacturing methods

Compositions of the present invention, normally extruded from the melt and, thus, can be prepared using simple mixing and extruding. The components of the composition are weighed and then mixed, for example, using a mixer of Brabender or Baker Perkins, usually, though not necessarily, at an elevated temperature is re, for example, approximately 90-140°C.

Optionally can be added solvents or water. The resulting composition may ekstrudirovaniya using single-or dual extruder, or granulomatosa. Alternative components of the composition may be melted separately and then mixed prior to extrusion. Preferably the composition is extruded directly onto an appropriate substrate, such as lining or removable lining, and then pressed. The thickness of the obtained film containing hydrogel, for most purposes will be in the range of about 0,050-0,80 mm, usually in the range of about from 0.37 to 0.47 mm

Alternative compositions can be produced by casting from a solution, by mixing components of the composition in an appropriate solvent, for example, in a volatile solvent such as ethyl acetate, or lower alkanols (e.g., ethanol, isopropyl alcohol and the like)are especially preferred at a concentration typically in the range of about 35-60% wt./volume. The solution was poured on an appropriate substrate, such as a layer of lining or removable strip, as above. As the mixing and molding is preferably carried out at ambient temperature. Then, the substrate coated with the film is fired at a temperature within primerno-100°C, optimally about 90°C for a time period of about 1-4 hours, optimally, about two hours. Accordingly, one of the embodiments of the present invention is a method for obtaining a film of hydrogel suitable for inclusion in the composition of the present invention, which includes the following stages: a solution of swelling in water, water-insoluble polymer, a hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with the hydrophilic polymer in the solvent; deposition of a layer on a substrate to create the coating; and heating the substrate with the coating to a temperature in the range of about 80-100°C for a period of time in the range of about 1-4 hours, thereby creating a film of hydrogel on the substrate.

When are desirable adhesive composition of the hydrogels, the preferred method is extrusion from the melt, although still can be used by casting from solution. For the manufacture of essentially non-sticky compositions casting from solution is preferred. In addition, extrusion of the melt can be used for any of the compositions of the present invention. Technologies or extrusion from the melt, or casting from solution can be used for the manufacture of semi-transparent compositions, x is thee for these embodiments casting from solution is, generally preferred. Accordingly, another variant of implementation of the present invention is a method of forming a composition consisting of a continuous hydrophilic phase, which includes the following stages: processing in the molten state when passing through the extruder a mixture of swelling in water, water-insoluble polymer, a hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with the hydrophilic polymer, to form an extruded composition; extruding the composition in the form of a film of the desired thickness on the corresponding substrate; and, after cooling, load the film with an aqueous solution of peroxide, to obtain the concentration of the whitening agent is from about 1 to 20% wt.

The present invention also involves obtaining a multilayer system, which contains one or more additional layers of hydrogel or not of the hydrogel. For example, it may be desirable to include additional active agents that may be not be compatible with bleaching agent during storage. Thus, one of the layers may be a layer of hydrogel containing a bleaching agent and the other layer (s) may contain additional active substances. These other layers may be made to the notizie hydrogel, described herein, or any other biocompatible material known in the art (for example, polyisobutylene, dimethylsiloxane, ethylene vinyl acetate, polyvinyl acetate, acetate, butyrate, cellulose propionate, ethyl cellulose and water-insoluble acrylate). In addition, depending on the stacking order of layers may be desirable receiving adhesive layer, such as layer, which should be placed directly on the teeth, and non-sticky layer, for example an outer layer that is located closest to the lips. Another advantage of the multilayer system is that the ratio of the polymers used in the last layer can be modified to obtain a non-sticky layer in order to avoid the necessity of inclusion in the product separate protective layer.

In one of the embodiments the composition comprises an outer surface, which serves as the outer surface of the composition after application to the tooth surface; an adhesive layer for contact with the teeth, stick to them, which, as a rule, will constitute the adhesive composition of the present invention, optionally containing additional whitening agents; and remove remove the gasket. For example, removing the removable strip composition is applied to the teeth again, to be processed and placed on the tooth surface so that the layer for contact with the teeth were in contact with them. In another embodiment, the composition is packaged without layer lining or removable strip. Accordingly, after removal from the packaging composition ready for application to the teeth.

The substrate is a primarily structural element and composes support either during production or during use. The material used for the substrate, should be inert and incapable of absorbing composition of the hydrogel. Also the material used for the substrate, should allow the tool to follow the contours of the teeth and comfortably be worn in the mouth without rubbing or other irritation of lips or tongue. Examples of materials suitable for the substrate, are pelistry, polyethylene, polypropylene, polyurethanes and polyetherimide. The thickness of the substrate preferably ranges from about 15 microns to about 250 microns, and may, if desired, be given to metallizirovanaya or be supplied with a matte finish, suitable for printing.

In one of the embodiments, the substrate is preferably, though not necessarily, blocking (i.e. not "breathing") and prevents bleaching agent in which oppozitsii to flow through the layer and in contact with the mucous membranes of the mouth and gums. When it is ready for use, the composition is pre-moistened, so that the adhesiveness is increased, and the composition will adhere to the teeth. One of the advantages of this variant implementation is that the bleaching agent being unable to flow through the substrate and to cause irritation in individuals with sensitive bleaching agent or any odor or feeling.

Other suitable substrate materials can be polimernye materials such as waxes (e.g., microcrystalline or paraffin waxes) and/or laminate wax/foam. Paraffin waxes are low molecular weight hydrocarbons, straight chain, with a melting temperature of about 48-75°C and with a molecular mass of approximately 300-1400 g/mol and, as a rule, obtained by Fischer-Tropsch synthesis. Microcrystalline waxes are flexible and amorphous in appearance and tend to have higher tensile strength and smaller size crystals than paraffin waxes. Microcrystalline waxes typically have a melting point of about 60-95°C and a molecular weight of about 580-700 g/mol and contain mainly hydrocarbons with branched chain and some compounds of the ring type, although there might be a hydrocarbon straight chain. M is a material predetermined substrate may also be a foam with open cells, such as polyurethane, polystyrene or polyethylene foam.

In another alternative embodiment, the substrate is a barrier, and for this reason can completely hydrogenate itself in situ in position on the teeth.

Remove the gasket is a disposable element, which serves to protect the system before applying. Remove the gasket should be formed from a material impermeable to the bleaching agent and the composition of the hydrogel, which is easily separated from the contact adhesive. Remove the strip, as a rule, treated with silicone or fluorocarbons and are typically made poliesterov and polyethylene terephthalate.

The preferred composition, typically made using acrylate polymer as a water-insoluble, swellable polymer in water; and a mixture of polyvinylpyrrolidone and polyethylene glycol as a mixture of hydrophilic polymer and a complementary oligomer capable of the formation of hydrogen bonds with the hydrophilic polymer.

The adhesive film composition may be obtained by thermal melting and mixing the above components together at temperatures in the range of about 100 to 170°C.

A film with the desired thickness of the extruded on an appropriate substrate. An alternative to the components can be dissolved in a single solvent or a mixture thereof, and the solution can be poured on shooting film or a protective film. Then the solvent evaporated to obtain a film of the hydrogel.

One way to load songs bleaching agent comprises layering the desired bleaching agent in aqueous solution on the surface of the hydrogel is placed on an appropriate substrate, or placing a bleaching agent directly to the substrate. Then on top of the compositions is installed (mounted) remove the gasket, forming a multilayer structure, and the solution containing the bleaching agent is absorbed in the composition, due to its property of swelling in water. Alternative composition, layered on a substrate may be immersed in a solution containing the desired concentration of the whitening agent, and the solution is absorbed in the composition. By measuring the rate of increase of mass in the absorption liquid may be determined and controlled load percentage composition of a bleaching agent.

Another approach to load a bleaching agent in the composition is to add a bleaching agent in the form of a solid or in the form of a solution of the composition dissolved in the solvent. The mixture is then poured as usual on the appropriate substrate and allow it to dry, although when using this method of load, it is desirable t which is lower drying temperature. Compositions produced in this manner can be dried at ambient temperature over a period of time in the range of about 1 hour to several days.

Typical film thickness is from about 0.050 to 0.80 mm, preferably from 0.25 to 0.50 mm film Thickness is not critical and may vary in accordance with the concentration of bleaching agent included in the film, the length of time during which the film should be in contact with the teeth, the level of comfort desired by the user, and the level of staining, which it is desirable to correct.

V. applications

In practice, the composition can be used simply by removing the product from its packaging, remove, remove gasket (when it is turned on) and applying an adhesive layer on the teeth to be whitened (or on any surface of the body, if you should use another useful property of the whitening agent). Teeth whitening systems described in the description, can be created with different sizes, so that the composition can be applied to the entire tooth or part thereof and any number of teeth simultaneously. The substrate, when it prevents, reduces or prevents leakage of the bleaching agent from the composition, at a time when the user wears the composition within VC is imago period of time. The composition can be maintained in the desired position in a short time, for example, several minutes, several hours, all day or overnight, and then removed when it reaches the desired degree of bleaching. Can create a translucent composition, and it is worn without being distracting or noticeable to others.

The composition can be worn for an extended period of time, but usually will be worn for a specified period of time from about 10 minutes to about 24 hours. When using teeth whitening preferred period of time is from about 10 minutes to about 8 hours (e.g. during the night), from 30 minutes to about 1 hour is also the preferred option for implementation.

The user can create a song around the upper or lower teeth, applying normal pressure manually on a substrate, using fingertips and thumbs, optional, by moistening composition before application. Considering that the surface area of the tip of the thumb or finger in the average adult is approximately one square centimeter, the normal pressure generated by the tips of the fingers or thumb, is from about 100,000 to about 150,000 PA (that eats is about 3 pounds or 1.36 kg) per square centimeter. The pressure is generally applied to the composition through each tip of the finger or thumb for approximately one or two seconds. After the pressure applied to the substrate by means of the fingers or the thumb is removed, the composition remains in the same form and adhered to the surface of the teeth and adjacent soft tissues on which it is formed.

When the user is ready to remove the composition, the composition can be removed simply by removing it from the surface of the teeth or other body surface. Optionally, the composition may be re-glued for extra time of bleaching. Any remainder after it are minimal and can be removed using conventional methods of cleaning the teeth.

In one of the embodiments of the present invention the composition is a solid and is a self-adhesive material and absorbs water.

The composition can also be applied as non-solid composition, for example, be applied as a liquid or gel. For example, the user may squeeze the composition from a tube on your finger for application to the teeth, squeeze the composition from the tube directly on the teeth, to apply the composition by means of a brush or other applicator, and so forth. After evaporation of the solvent composition of the liquid or gel height is Hayot with the formation of the polymer film type matrix or gel on the tooth surface. In one of the embodiments of this composition liquid or gel-forming film, the hydrogel contains a quantity of water or other solvent, sufficient to ensure the flow properties of the. In another embodiment, the polymeric components of the composition of the liquid or gel is soluble in water-ethanol mixture as at ambient temperature, and the freezing temperatures of about 4°C, and is miscible with the solvent evaporates. In yet another embodiment, the composition is liquid or gel-forming film, the polymer composition has a lower critical solution temperature in a mixture of ethanol-water, equal to about 36°C. the Obtained film after evaporation of the solvent) is preferably insoluble or slowly soluble in saliva at body temperature, in order to ensure long-term contact between hydrogen peroxide and tooth enamel. Finally, the hydrogen peroxide must be stable both in liquid and gel compositions, as well as in the polymer film during drying.

The implementation of the present invention will be used, unless otherwise indicated, conventional methods of polymer chemistry, manufacturing adhesives and preparation of hydrogels, which are known to experts in this field. Such technologies are fully Clare is observed in the literature.

You must understand that, although the present invention is described in connection with preferred specific variants of its implementation, the above description and examples that follow further illustrate and not limit the scope of the present invention. Other aspects, advantages and modifications will be clear to experts in the field to which the present invention relates.

The following examples are given in order to provide the specialist in this field a full description and instructions on how to obtain and use the compounds of the present invention, and are not intended to limit the scope of what the authors consider it their invention. Efforts have been made to ensure accuracy with respect to quantities (e.g., amounts, temperatures and the like), but some errors and deviations should be accounted for. Unless otherwise indicated, shares are mass fractions, temperature is in degrees Celsius (°C), and the pressure is atmospheric or near it.

In the examples, the following abbreviations and trade names:

Eudragit L100-55methacrylic acid copolymer (Rohm America Inc.)
Eudragit RS 100PEGthe polyethylene glycol 400
PVPpolyvinylpyrrolidone Kollidon® 90 (BASF)

EXAMPLES

Example 1

Manufacturing solid composition

In one of the embodiments of the composition for whitening teeth are made from the following ingredients using the method of extrusion from the melt:

Eudragit L100-559% wt.
PVP44% wt.
PEG22% wt.
The peroxide6% wt.
Water, stabilizers, pH modulators19% wt.

Melt ingredients processed in a single screw extruder of Brabender as follows: first, in the extruder add Eudragit L100-55, and then PVP and PEG at a temperature of 100-150°C. the Composition ekstragiruyut at a thickness of 0.35 mm between two removable spacers made of polyethylene terephthalate. In the extruded film add the hydrogen peroxide solution.

Example 2

Vysvobozhdayushchii hydrogen in vitro from solid composition

The release of hydrogen peroxide in vitro from the composition for tooth whitening according to the present invention in buffer pH 7.0 examine and compare with peroxide released from a commercial product Crest Whitestrips™ (a product of Proctor & Gamble Co., Cincinnati, OH, referred to as "product Crest"). Product Crest contains 5.3% of hydrogen peroxide in the gel Carbopol 956 thin polyethylene film.

The release of hydrogen peroxide in vitro from compositions containing 3, 6 or 9% peroxide (produced as described in example 1 are compared with a release of hydrogen peroxide from the product Crest. Studied composition or product Crest give the opportunity to release peroxide in the solution through filter paper and measuring the level of peroxide using standard analytical methods. For product Crest of the observed levels of peroxide decreases to baseline within approximately 30 minutes. These data are similar to published data (Pagel P.A., et al. (2000) Vital Tooth Whitening with a Novel Hydrogen Peroxide Strip System: Design, Kinetics, and Clinical Response. Compendium, Suppl. 29, Vol. 21: S10-S15).

Composition for tooth whitening according to the present invention release the peroxide at a speed proportional to the initial concentration. The compositions of the present invention as well as found, release the peroxide with a higher speed than the Crest product, for all time, when islebe the camping peroxide content: 5, 30 and 60 minutes. The release of peroxide to the composition containing 6% peroxide, which is close to the Crest product is about 7.5, 24 and 10 times greater than the rate of release for a product Crest, at each moment of time, respectively. The release of peroxide to the composition containing 3% peroxide is approximately 3, 7, and 5 times greater than the rate of release for a product Crest, at each moment of time, respectively.

Example 3

The efficiency of the solid composition

The efficacy of compositions for whitening teeth is investigated using the following procedure. The subject examines the effectiveness of the composition for whitening teeth made in accordance with the procedure described in example 1 by coating the composition on the lower teeth once a day, within 1 hour, for 6 consecutive days. The shade of the teeth of the subject is measured using the index of shades Professional Tooth Shade before and after dental treatment composition for whitening teeth. On day 1 the teeth of the subject have shade according to the scale 12, and within one hour of processing composition for whitening teeth are a shade according to the scale 10. After one hour of processing composition for whitening teeth in day 2 the teeth of the subject have shade according to the scale 8. After one hour of treatment at day 3, the teeth of the subject have shade coz the ACLs scale 5. Similarly, after one hour of treatment at day 4, the teeth of the subject have shade according to the scale 4/5. On day 5 after one hour of treatment, the teeth of the subject have shade according to the scale 2/3. The lightest shade is achieved after an additional half-hour treatment day 6 with achievement of the shade 2. Thus, the effectiveness of the compositions for whitening teeth is obvious, with the measured results obtained within one hour of processing.

Example 4

Manufacture of non-solid composition

Composition for whitening of the teeth is made of the following ingredients (formula A):

Deionized water35,0% wt.
Ethanol35,0% wt.
Eudragit L 100-554,00% wt.
PEG1,00% wt.
PVP7,00% wt.
Proximation18,0% wt.
Sodium citrate0,13% wt.

The composition is stirred at low speed laboratory mixer with high torque momento the Cole-Parmer, equipped with a paddle stirrer with Teflon coating (diameter 2 inches), as follows. Deionized water is mixed with ethanol followed by the addition of PEG. Then add sodium citrate with vigorous stirring. Slowly add the powder Eudragit L 100-55 (2-5 min) with vigorous stirring (500-600 rpm). After about 5-10 minutes (no need to wait until then, until you dissolve all of Eudragit) slowly add the powder PVP (within 5 min). High speed stirring is maintained for 5-10 minutes Add the powder peroxidation (within 1-2 min) and the mixture is stirred to obtain a homogeneous solution (about 30 minutes at 800-900 rpm). Then the solution is stored during a time period of 2-5 hours, to allow for dissipation of air bubbles.

Example 5

Manufacture of non-solid composition

A composition for whitening teeth are made of the following ingredients (formula B):

Deionized water35,0% wt.
Ethanol35,0% wt.
Eudragit L 100-552,50% wt.
PEG1,92% wt.
PVP6,00% wt.
Proximation18,0% wt.
Sodium citrate0,08% wt.
Methocel A4C1,50% wt.

The composition is stirred at low speed laboratory mixer with high torque Cole-Parmer, equipped with a paddle stirrer with Teflon coating (diameter 2 inches). Deionized water is mixed with ethanol followed by the addition of PEG. Then add sodium citrate with vigorous stirring. Slowly add the powder Eudragit L 100-55 (within 5 min) with vigorous stirring (500-600 rpm), followed by slow addition (over 5 min) powder Methocel A4C with vigorous stirring (500-600 rpm). After about 10 minutes slowly add the powder PVP (within 5 min). High speed stirring is maintained for 5-10 minutes Add the powder peroxidation (within 1-2 min) and the mixture is stirred to obtain a homogeneous solution (approximately 30-60 minutes at 800-900 rpm). Then the solution is stored during a time period of 2-5 hours, to allow for dissipation of air bubbles.

Example 6

A comparative study of the in vitro dissolution for non-solid composition

Dissolved the e non-solid compositions for whitening teeth manufactured in accordance with the procedures described in examples 4 (formula A) and 5 (formula B), compared with the dissolution of a commercial product, translucent bleaching gel Simply White™ (product of Colgate-Palmolive Company, New York, NY, referred to as "product Colgate"), which contains 18,0% wt. peroxidation. The dissolution process are examined through methods V microinterferometric.

Formula A, as detected, generates a clear phase boundary separating the swollen polymer composition from the polymer solution. The phase boundary is observed a sharp drop in the concentration of the polymer (and hence viscosity of the polymer). The existence of such a boundary is not detected in the zone of mutual diffusion of the product Colgate/water, where the pattern of interference is typical of unlimited mixed system, with a monotonic decrease in the concentration of the polymer (and hence viscosity of the polymer) in the direction from the matrix of the composition to water. Formula B, as found, has a heterogeneous (colloidal) nature. A clear phase boundary is formed between the turbid gel and translucent aqueous solution. Formula B as well as found, has faster soluble" fraction and a "slower soluble" fraction. Slowly soluble fraction form relatively thin layer, covering the muddy heterogeneous nab Hsi gel. In contrast to the Colgate product as formula A, and B, in contact with aqueous environments is capable of forming a continuous integral coating of viscous swollen gel, separated from the liquid solution clear phase boundary. The formation of a phase boundary for formulas A and B observed in aqueous media at different pH, in the range from 4.6 to 7.5.

Using formulas A and B form a clear phase boundary separating the swollen polymer from the polymer solution. Such boundaries do not exist in the area of mutual diffusion of Colgate and water, for which the interference pattern is typical for a fully mixed system, with a monotonic decrease in the concentration of the polymer (and hence viscosity of the polymer) in the direction from the matrix of the formula A and the matrix formula B to the water.

Effective constants of mass transfer of water in the formula A or B of formula A or B in the water are comparable to Colgate and formulas A and B. However, in contrast to the Colgate product, if the product is observed the formation of a clear phase boundary separating the swollen integral gel from the liquid aqueous solution. The effective diffusion coefficient of the phase boundary by 1-2 orders of magnitude lower than for water in the formula A or B of formula A or B in water. The layer of the swollen gel formed formulas A and B in aqueous media, can play a role for etogo layer with a slow rate of dissolution. The swollen gel also provides mechanical support to increase the residence time of the formulas A and B on the surface of teeth.

The kinetics of penetration of the composition into the water is almost identical for formulas A and B, while the kinetics of displacement of the boundary between phases slower for formula B. the Effective constants of mass transfer are comparable to product Colgate and formulas A and B. However, in the case of formulas A and B, there is a clear phase boundary separating the swollen integral gel from the liquid solution.

In real conditions of use, the erosion of formulas A and B (and hence their time socks) depends mainly on two factors: 1) the processes of free mutual diffusion of compositions and water (saliva) and 2) accidental mechanical shear stresses that are attached to the floor in a period of time socks (i.e. friction caused by movements of the lips). The first factor can be considered as the limiting ideal (unperturbed) process, while the latter may influence the duration of socks dramatic and random, as each case of rupture of the coating dramatically alter the original conditions of mutual diffusion (i.e. the thickness of the coating and the ingredients of the composition). Preliminary studies show socks that formulas A and B able to stay on the teeth for more than the 10-15 minutes while the Colgate product, as detected, remains on the teeth for 2-3 minutes.

Example 7

Comparative efficacy in vitro for non-solid compositions

The efficiency of in vitro non-solid compositions for whitening teeth made in accordance with the procedure described in example 4 (formula A), compared with the dissolution of the Colgate product.

The composition of formula A and the product Colgate applied to the wall of the Cup, on the site, moistened tea, to demonstrate the "first" processing. After 30 seconds in a Cup of water is added, covering the surface with the coating. After 30 minutes the water is removed and the Cup is washed with water to remove any residual gel coating on the wall. The experiment is repeated by coating each composition on the same plot to demonstrate the "second" processing.

Image treated plots recorded with a digital camera, and the obtained image is converted into an image with 256 pixels grayscale, using the software Scion Image. Images are calibrated so that the pixel value 1 corresponds to a pure white color, and a value of 256 corresponds to black color. The intermediate pixel values (from 2 to 255), thus, correspond to intermediate colors, with black, increasing from 1 to 256. Software is the first software Scion Image is also used to measure the intensity of a color pixel/pixel 2) treated plots. The results presented below demonstrate that the composition of A formula whitens better than commercially available product Colgate. A higher standard deviation observed for a formula A, is explained by the less homogeneous the original color of the plot moistened tea.

The average intensity (pixel/pixel2) S.O.)
Before processingAfter 1 treatmentAfter 2 treatments
Product Colgatefor 194.3 (3,8)185,7 (6,2)178,0 (6,6)
The formula A198,3 (5,2)178,6 (8,2)167,6 (9,0)

This experiment is repeated using a non-solid composition for whitening teeth made in accordance with the procedure described in example 5 (formula B), except that only have a "first" processing.

Average intense the activity (pixel/pixel 2) S.O.)
Before processingAfter 1 treatment
Product Colgate116,9 (6,6)89,4 (6,79)
Formula B117,3 (5,1)79,6 (7,3)

As can be seen from the in vitro data presented above, the efficiency of the bleaching compositions of the formula A markedly superior product Colgate, the properties of the composition of formula B are intermediate between the properties of the product Colgate and formulas A.

Example 8

The release of hydrogen peroxide in vitro from non-solid composition

The release of hydrogen peroxide from a non-solid composition for whitening teeth of example 4 (formula A) is compared with the dissolution of the Colgate product. The Colgate product is poured on to remove the gasket and dried at ambient temperature for one day. The resulting film product Colgate thickness of approximately 300-400 μm, placed in a glass chemical beaker and add 200 ml of deionized water. The composition of formula A is poured on the bottom of the chemical glass. After 2-3 minutes add 200 ml of deionized water. After the passage of an appropriate period of time, the solution was carefully separated from the swollen residue and determine the end is the acidity of hydrogen peroxide in accordance with the method of titration USP (United States Pharmacopeia). The amount of hydrogen peroxide released from Colgate product and formula A shown below.

Percent (wt./wt.) the released hydrogen peroxide
Time (minutes)123510152030
Product Colgate---38,7---47,772,478,796,8---
The formula A35,035,959,567,571,9---79,290,0

In contrast to the Colgate product profile release of hydrogen peroxide from a film formed formula A, is slow and is characterized by the accelerated delivery of the active agent within the first patient. When 10 minutes of contact with water formula releases A less hydrogen peroxide than Colgate. After 20 minutes of contact with water the product Colgate does not contain hydrogen peroxide, while the formula A contains 20% of the initial load of hydrogen peroxide. This is proof of a stronger binding of hydrogen peroxide with polymers of formula A, than in the Colgate product. Comparing the data on the release and dissolution of the film, it is also concluded that the content of hydrogen peroxide included in the film of the formula (A) may be divided into categories or weaker bound hydrogen peroxide, or more strongly bound hydrogen peroxide. This is the opposite of the product Colgate, where all the hydrogen peroxide is weakly associated.

Example 9

Comparative efficacy in vivo non-solid compositions

Comparative efficacy in vivo non-solid composition for tooth whitening formula A and formula B is compared with the dissolution of the Colgate product. The effectiveness of the whitening formula A and formula B is compared with the efficiency of a product Colgate, using the scale values of the shades pointer Vita shades. The study is a randomized (random) double-blind pilot study with parallel groups. Eleven subjects with a tint value on a scale of values, yasat the La Vita shades, equal to A3 or darker, at least four of the six upper anterior teeth are invited to participate in the study.

All 11 subjects randomly assigned to one of three treatment groups based on the value of Vita shades for the upper Central incisors. Subjects receive a sufficient amount of product for 14 days and receive instructions on how to use the product twice a day for two weeks. On the basis of estimates by Vita and interviews with the subjects is clear that the formula A, formula B and Colgate product, all provide statistically significant whitening effect after seven days of treatment. Best whitening effect is observed for the formula A. Formula B shows the bleaching effect, which is intermediate between exposure to formula A and Colgate product. The formula demonstrates A earlier whitening effect on the teeth compared to Colgate product.

Example 10

Manufacture of non-solid composition

A composition for whitening teeth are made from the following ingredients:

PVP0,33% wt.
PEG0,17% wt.
Eudragit RS 1003,00% wt.
Tributyltin7,00% wt.
The peroxide10,00% wt.
Ethanol17,00% wt.
The ethyl acetate22,5% wt.
Isoamylase1,00% wt.
Ethyl formate7,00% wt.

1. Non-solid composition containing
(a) 2-6 wt.% swelling in water, water-insoluble polymer;
(b) a mixture of a hydrophilic polymer comprising 4-10 wt.% and a complementary oligomer capable of the formation of hydrogen bonds with hydrophilic polymer comprising 0.5 to 10 wt.%, and
(c) a bleaching agent.

2. The composition according to claim 1, in which swelling in water, water-insoluble polymer is an ester of cellulose or polymer, or copolymer of acrylate-based.

3. The composition according to claim 2, in which an ester of cellulose is at least one cellulose polymer containing monomer units neeterificirovannah cellulose monomer units of the cellulose acetate, and or monomer units of the cellulose butyrate, or monomer units of the cellulose propionate.

4. The composition according to claim 3, in which the Torah polymer cellulose is a acetate butyrate cellulose.

5. The composition according to claim 3, in which the polymer cellulose is an acetate propionate cellulose.

6. The composition according to claim 3, in which the complex composition of the cellulose ether comprises a mixture of the acetate butyrate cellulose acetate propionate cellulose.

7. The composition according to claim 2, in which the polymer or copolymer based on acrylate is selected from polymers and copolymers of acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate or ethyl methacrylate.

8. The composition according to claim 7, in which swelling in water, the polymer is a copolymer of methacrylic acid and methyl methacrylate.

9. The composition of claim 8 in which the copolymer has a ratio of free carboxyl groups to ester groups of about 1:1-1:2.

10. The composition according to claim 1, in which the hydrophilic polymer is selected from the group consisting of poly(N-vinylacetate), poly(N-vinylamide), poly(N-alkylacrylate), polyacrylic acid, polymethacrylic acid, polyvinyl alcohol, polyvinylidene, and their copolymers and mixtures.

11. The composition according to claim 10, in which the hydrophilic polymer is selected from the group consisting of poly(N-vinylacetate), poly(N-vinylamide), poly(N-alkylacrylate) and their copolymers and mixtures.

12. The composition according to claim 11, in which the hydrophilic polymer is a poly(N-vinylacetal).

13. Composition by A11, in which the hydrophilic polymer is a homopolymer of poly(N-vinylacetate).

14. The composition according to claim 10, in which poly(N-vinylacetal) is selected from the group consisting of polyvinylpyrrolidone, polyvinylcaprolactam, and mixtures thereof.

15. The composition according to 14, in which poly(N-vinylacetal) is a polyvinylpyrrolidone.

16. The composition according to 14, in which poly(N-vinylacetal) is polyvinylcaprolactam.

17. The composition according to claim 10, in which the hydrophilic polymer has srednekamennogo molecular weight in the range of about 100000-2000000.

18. The composition according to claim 10, in which the hydrophilic polymer has srednekamennogo molecular weight in the range of about 500000-1500000.

19. The composition according to claim 1, in which the complementary oligomer has a molecular weight in the range of about 45-800.

20. The composition according to claim 19, in which the complementary oligomer has a molecular weight in the range of about 45-600.

21. The composition according to claim 19, in which the complementary oligomer is selected from the group consisting of a polyalcohol, Monomeric and oligomeric alkalophile, alkylene glycols, polyalkylene glycols with carboxyl end groups of the polyalkylene glycols with terminal amino groups, ether alcohols, alkanediols acid and carbonic acid.

22. The composition according to item 21, in which the complementary oligomer vybere the Xia group, consisting of alkylene glycols and polyalkylene glycols with carboxyl end groups.

23. The composition according to item 22, in which the complementary oligomer is selected from the group consisting of polyethylene glycol and polyethylene glycol with a carboxylic terminal groups.

24. The composition according to item 22, in which the complementary oligomer is a polyethylene glycol.

25. The composition according to claim 1, in which the bleaching agent is selected from the group consisting of peroxides, metal chlorite, perborates, percarbonates, peroxyketal, and their combinations.

26. The composition according A.25, in which the bleaching agent is a peroxide selected from the group consisting of hydrogen peroxide, calcium peroxide, urea peroxide, and mixtures thereof.

27. The composition according A.25, in which the peroxide is an organic peroxide.

28. The composition according to item 27, in which the organic peroxide is selected from the group consisting of dialkylamides, diarilpirimido, complex perepelov, pentaborate, getoperation and hydroperoxides.

29. The composition according to p in which dialkylphenols represents a tert-butylperoxide or 2,2-bis(tert-BUTYLPEROXY)propane.

30. The composition according to p in which deciphered represents a benzoyl peroxide or acetylmuramic.

31. The composition according to p, in which complex perefer PR is dstanley a tert-butyl perbenzoate or tert-butyl per-2-ethylhexanoate.

32. The composition according to p in which perikaryon is dicetylperoxydicarbonate or dicyclohexylperoxydicarbonate.

33. The composition according to p in which keeper.exe is cyclohexanedione or methylethylketone.

34. The composition according to p, in which the hydroperoxide is cumonherface or tert-butylhydroperoxide.

35. The composition according A.25, in which the bleaching agent is a metal chlorite selected from the group consisting of chlorite calcium, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, potassium chlorite, hypochlorite and chlorine dioxide.

36. The composition according to claim 1, additionally containing flavorant.

37. The composition according to p in which flavorant is selected from the group consisting of Wintergreen, pepper mint, curled mint, menthol, fruit of flavorants, vanilla, cinnamon, spices, aromatic oils and oleosa, and their combinations.

38. The composition according to claim 1, additionally contain a sweetener selected from the group consisting of sucrose, fructose, aspartame, xylitol and saccharin.

39. The composition according to claim 1, additionally containing at least one additive selected from the group consisting of fillers, preservatives, pH regulators, softeners, thickeners, coloring agents, pigments, dyes, reflective particles, FL is sarantou, sweeteners, stabilizers, hardening agents, agents to reduce stickiness and amplifiers permeability.

40. The composition according to claim 1, in which the relative amount of swelling in water of the water-insoluble polymer, a hydrophilic polymer and a complementary oligomer are selected in such a way as to make the composition is translucent.

41. The composition according to claim 1, where the composition is a liquid or gel.

42. The composition according to paragraph 41, which contains about 0.1-60 wt.% bleaching agent.

43. The method of teeth whitening, including
the coating composition according to claim 1 on the teeth that need whitening; and
deleting songs when it reaches the desired degree of bleaching.

44. The method according to item 43, in which the composition is moistened prior to application to the teeth.

45. The method according to item 43, in which the composition contains a removable lining, and a removable strip is removed before applying the composition to the teeth.

46. The method according to item 43, in which the desired degree of whitening is achieved in a given period of time.

47. The method according to item 46, in which a specified period of time is from about 10 minutes to about 24 hours

48. The method according to p in which a specified period of time is from about 10 minutes to about 8 hours

49. The method according to p in which a specified period of time is about 30 min - 1 hour

50. SPO is about on p.43, in which the composition can be worn for an extended period of time.

51. The method according to item 43, in which the composition is applied as a liquid or gel.

52. The composition according to claim 1, in which the complementary oligomer is present in an amount of 0.1-2 wt.%.

53. The composition according to claim 1, where the composition is capable of forming a continuous integral coating of viscous swollen gel, separated from the liquid solution clear phase boundary in contact with the aquatic environment.

54. The composition according to claim 1, additionally containing a mixture of water-ethanol, in which the polymers are soluble both at ambient temperature and the freezing temperatures of approximately 4°C.



 

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3 cl, 4 tbl

FIELD: chemistry.

SUBSTANCE: invention refers to technology of hull-kernel particles which can be used to modify impact strength of poly(met)akrylate moulding compositions. According to method a) water and emulsifier b) are added with 25.0 to 45.0 mass fractions of the first composition containing A) alkylmetacrylate 50.0 to 99.9 mass fractions, B) alkylakrylate 0.0 to 40 mass fractions, C) cohesive monomers 0.1 to 10.0 mass fractions, and D) styrene monomers 0.0 to 8.0 mass fractions, and polymerised, c) added 35.0 to 55.0 mass fractions of the second composition containing E) (met)akrylates 80.0 to 100.0 mass fractions, F) cohesive monomers 0.05 to 10.0 mass fractions, and G) styrene monomers 0.0 to 20.0 mass fractions, and polymerised, d) added 10.0 to 30.0 mass fractions of the third composition containing H) alkylmetakrylates 50.0 to 100.0 mass fractions I) alkylakrylates 0.0 to 40.0 mass fractions and J) styrene monomers 0.0 to 10.0 mass fractions, and polymerised. Method is distinctive in that e) each polymerisation cycle is performed at temperature within 60 to 90°C and f) fractional content of all substances is selected so that total weight A) to J) per total weight of aqueous dispersion exceeds 50.0 mass %. Presented method is used to produce impact strength modifiers minimum content of which provides sufficient improvement of impact strength when tested on cut moulding composition samples, not degrading at the same time other important properties of moulding composition.

EFFECT: production of impact strength modifiers minimum content of which provides sufficient improvement of impact strength when tested on cut moulding composition samples, not degrading at the same time other important properties of moulding composition.

17 cl, 8 tbl

FIELD: composite polymer biomedicine materials containing polymer binder, biocompatible filler and carbon reinforcing filler.

SUBSTANCE: claimed composition contains polymer binder, namely mixture of polymethylmethacrylate or methylmethacrylate copolymer with methylacrylate and monomer methylmethacrylate in ratio of polymer part to monomer from 1:0.3 to 1:0.5 mass pts (50-72 mass pts); peroxide initiator (0.05-0.5 mass pts): carbon continuous fibers of 200-1000 filaments made of hydratcellulose fiber of polyacrylonitrile fiber (2-10 mass pts); and hydroxyapatite as filler (25-40 mass pts). Method for production of material from claimed composition useful in manufacturing of jowl implants also is disclosed.

EFFECT: polymer material having natural bone-like properties.

3 cl, 10 ex, 1 tbl

FIELD: organic chemistry, impregnating compositions.

SUBSTANCE: invention relates to composition used for impregnation of a polishing disk. The composition for impregnation of polishing disk comprises a binding agent aqueous solution representing a mixture of an aqueous emulsion of co-polymer prepared by emulsion polymerization of butyl acrylate, ethyl acrylate, methyl methacrylate and acrylic acid amide with the content of basic substance 50 ± 5%, liquid water glass and oxyethylated lanolin in the following ratio of components, mas. p. p.: copolymer of butyl acrylate, ethyl acrylate, methyl methacrylate and acrylic acid amide as measure for dry residue, 15-50; liquid water glass, 3-12; oxyethylated lanolin, 1-6, and water, 45-105. Invention provides enhancing stability and to reduce cost in making the polishing disk.

EFFECT: improved and valuable properties of composition.

2 tbl, 4 ex

FIELD: polishing materials.

SUBSTANCE: invention relates to manufacturing cotton polishing disks based on friction effect. The composition for making polishing disks comprises a binding agent aqueous solution wherein an aqueous emulsion of copolymer 15-50% of its total mass is used and prepared by emulasion polymerization of butyl acrylate, ethyl acrylate, methyl methacrylate and acrylic acid amide in the ratio, mas. p. p.: butyl acrylate, 140-160; ethyl acrylate, 140-160; methyl methacrylate, 205-231; acrylic acid amide, 17-19. Invention provides enhancing durability of polishing disks and to reduce cost in their making. Invention can be used for polishing table dishware and their parts made of stainless, devices for dental practice, jewelry articles, watches and so on.

EFFECT: improved and valuable properties of composition.

2 tbl, 9 ex

FIELD: polymer materials.

SUBSTANCE: composition contains, wt %: vinylidene fluoride 20-40, methyl methacrylate homopolymer or copolymer, acryl elastomer 5-18, and UV-absorbing substance 1-4. Invention also discloses jointly extruded films (options) and substrates covered by these films. Invention enables preparing composition with not rising UV-absorbing substances and manufacturing films showing high mechanical strength and providing high-quality adhesion to substrate while being resistant to radiation.

EFFECT: improved consumer's properties of films.

14 cl, 7 ex

The invention relates to a device for receiving the sheet of polymeric materials in vertical forms

The invention relates to a method and apparatus for receiving a sheet of polymeric materials in vertical forms

FIELD: chemistry.

SUBSTANCE: proposed method of producing a water and oil repellent agent involves emulsification of (a) 15-85 wt % perfluoroalkylethylacrylate, (b1) 5-65 wt % 2-ethylhexylmethacrylate and (b2) 1-40 wt % benzyl methacrylate in the presence of (c) a cation surface active substance of the polyethylene oxide adduct type, or neutralised organic acid compound of an amine, with polyethylene oxide chains, and (d) compounds based on polypropylene glycol, with molecular weight 300-3000, or hexylene glycol, with subsequent copolymerisation reaction in the presence of a polymerisation initiator, and mixing the obtained aqueous dispersion with (e) blocked isocyanate.

EFFECT: satisfactory water and oil repellent for synthetic and natural fibre.

5 cl, 22 ex, 5 tbl

FIELD: chemistry.

SUBSTANCE: invention refers to technology of hull-kernel particles which can be used to modify impact strength of poly(met)akrylate moulding compositions. According to method a) water and emulsifier b) are added with 25.0 to 45.0 mass fractions of the first composition containing A) alkylmetacrylate 50.0 to 99.9 mass fractions, B) alkylakrylate 0.0 to 40 mass fractions, C) cohesive monomers 0.1 to 10.0 mass fractions, and D) styrene monomers 0.0 to 8.0 mass fractions, and polymerised, c) added 35.0 to 55.0 mass fractions of the second composition containing E) (met)akrylates 80.0 to 100.0 mass fractions, F) cohesive monomers 0.05 to 10.0 mass fractions, and G) styrene monomers 0.0 to 20.0 mass fractions, and polymerised, d) added 10.0 to 30.0 mass fractions of the third composition containing H) alkylmetakrylates 50.0 to 100.0 mass fractions I) alkylakrylates 0.0 to 40.0 mass fractions and J) styrene monomers 0.0 to 10.0 mass fractions, and polymerised. Method is distinctive in that e) each polymerisation cycle is performed at temperature within 60 to 90°C and f) fractional content of all substances is selected so that total weight A) to J) per total weight of aqueous dispersion exceeds 50.0 mass %. Presented method is used to produce impact strength modifiers minimum content of which provides sufficient improvement of impact strength when tested on cut moulding composition samples, not degrading at the same time other important properties of moulding composition.

EFFECT: production of impact strength modifiers minimum content of which provides sufficient improvement of impact strength when tested on cut moulding composition samples, not degrading at the same time other important properties of moulding composition.

17 cl, 8 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to impregnation and hermetisation of porous products with thermally hardened compositions based on (meth)acrylic monomers. Claimed is thermally hardened composition for impregnation and hermetisation of porous products, containing (in mass fraction): 100 (meth)acrylic monomer, 0.1-0.5 nitronitrile, 0.01-0.04 hydrohynone, 0.004-0.03 disodium salt of ethylendiaminetetraacetic acid, 0.001-0.03 2,2,6,6-tetramethyl-4-oxopiperidin-1-oxyl and 0.5-5.0 non-ionogenic emulsifying agent. Method of impregnation and hermetisation of porous products includes their vacuum processing with further impregnation under vacuum and atmospheric pressure with abovementioned composition and hardening at temperature ≥90°C. Thermally-hardened composition has higher serviceability and allows to increase productivity of impregnation and hermetisation method essentially.

EFFECT: increasing productivity of method of impregnation and hermetisation of porous products by means of thermally-hardened compositions.

2 cl, 1 tbl, 15 ex

FIELD: technological processes.

SUBSTANCE: present invention relates to the technology of modifiers production on the basis of nuclear-shell type particles used for production of molding such as films, pipes, mirror housings etc. from poly(meth)acrylates. The nuclear-shell type particle consists of a nucleus, the first shell and, if required, the second shell that on every single case consist of alkylmetacrylate and styrene recurring units with minimum glass-transition temperature of 30°C. The said particles are produced by multistage emulsion polymerisation.

EFFECT: invention ensures implementation of the process with minimum labour costs and small investments for commercial deployment.

15 cl, 2 tbl

FIELD: physics.

SUBSTANCE: invention concerns manufacturing of integrated microcircuits and other electronic devices using planar technology based on photolithographic processes. The technical task was to develop a photoactivated composition for silicon dioxide film etching for photolithographic purposes, which would allow reduce technological process of photolithographical drawing in silicon layer. The offered composition contains (mass%): polymethylmethacrylate (3.2-3.9) as polymeric substrate, ammonium fluoride (3.0-3.7) as photosensitive component, and pyridine (75.0-80.3) and trifluoroacetic acid (12.1-18.8) as solvents.

EFFECT: application of the offered composition simplifies the technological process and decreases the number of flaws of production drastically.

1 cl, 2 ex

FIELD: heat-curable sealing compositions.

SUBSTANCE: composition is proposed, containing the following mass components: 100 (meth)acrylic monomer or its mixture with an allyic monomer, 0.5-2.5 initiator, 0.01-0.32 hydroquinone, 0.01-0.13 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl, 0.004-0.05 disodium salt of ethylenediaminetetraacetic acid, 20-125 filler and 5-30 functional additives. The proposed composition has polymerising activity at 100-250°C for 3-8 minutes and breaking stress of 605-15.5 MPa. This adhesive strength is sufficient for withstanding steam pressure of up to 4 MPa. Use of the proposed composition allows for repairing steam pipes with constant supply of steam.

EFFECT: design of a heat-curable sealing composition for repairing steam pipes without interruption of steam supply.

1 cl, 1 tbl, 5 ex

FIELD: textile industry.

SUBSTANCE: invention relates to manufacture of nonwoven fabrics possessing sorption ability and can be used in making various-modification filters suitable for cleaning liquid media. Impregnating composition contains blend constituted by latexes based on rigid chain- and flexible chain-nature copolymers taken at ratio between 95:5 and 50:5, respectively, solid filler, and water, wherein ratio of all components is expressed as 1:(2.5-3.0):1. Composition is obtained by mixing and vibration action in resonance mode at frequency 50-150 Hz and action time 5-15 min.

EFFECT: increased aggregative stability of composition and physicomechanical properties of material with no additional components added.

2 cl, 2 tbl, 6 ex

FIELD: composite polymer biomedicine materials containing polymer binder, biocompatible filler and carbon reinforcing filler.

SUBSTANCE: claimed composition contains polymer binder, namely mixture of polymethylmethacrylate or methylmethacrylate copolymer with methylacrylate and monomer methylmethacrylate in ratio of polymer part to monomer from 1:0.3 to 1:0.5 mass pts (50-72 mass pts); peroxide initiator (0.05-0.5 mass pts): carbon continuous fibers of 200-1000 filaments made of hydratcellulose fiber of polyacrylonitrile fiber (2-10 mass pts); and hydroxyapatite as filler (25-40 mass pts). Method for production of material from claimed composition useful in manufacturing of jowl implants also is disclosed.

EFFECT: polymer material having natural bone-like properties.

3 cl, 10 ex, 1 tbl

The invention relates to the field of solid state ionic conductors, namely, polymer electrolytes

The invention relates to the qualitative and quantitative composition of composite materials for the combination of crumb rubber, which is obtained by grinding waste rubber with other ingredients such rubber mixtures, which are intended for forming of new rubber products

FIELD: chemistry.

SUBSTANCE: proposed method of producing a water and oil repellent agent involves emulsification of (a) 15-85 wt % perfluoroalkylethylacrylate, (b1) 5-65 wt % 2-ethylhexylmethacrylate and (b2) 1-40 wt % benzyl methacrylate in the presence of (c) a cation surface active substance of the polyethylene oxide adduct type, or neutralised organic acid compound of an amine, with polyethylene oxide chains, and (d) compounds based on polypropylene glycol, with molecular weight 300-3000, or hexylene glycol, with subsequent copolymerisation reaction in the presence of a polymerisation initiator, and mixing the obtained aqueous dispersion with (e) blocked isocyanate.

EFFECT: satisfactory water and oil repellent for synthetic and natural fibre.

5 cl, 22 ex, 5 tbl

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