Method of treatment for trophic ulcers of venous etiology
SUBSTANCE: invention concerns medicine, laser medicine, and can be applied in treatment of trophic ulcers of venous etiology. Method involves processing of ulcer surface and skin around ulcer by air and gas flow with nitrogen oxide content 2000 ppm or more at 40°C, with 10 second exposition per 1 cm2. Further, 0.1% Radachlorine gel is applied as photo sensitiviser in amount of 0.2 g per 1 cm2 with 60 minutes exposition. Then laser emission of 0.665 mcm wavelength and light energy dosage of 150-200 J/cm2 is applied at 3-5 mm distance from wound surface. Afterwards intravenous blood irradiation is performed over cubital vein by laser emission of 0.632 mcm wavelength and radiation power of 5 mW with 15 minutes exposition. Treatment course comprises 10 daily procedures of air and gas flow processing and intravenous blood irradiation and 5-8 photodynamic therapy procedures performed over 2 day interval.
EFFECT: improved neurotrophic regulation of damaged tissues, antimicrobe effect, reduced frequency of purulent complications, improved blood flow properties, prevented resistance of ulcer microflora to antibiotics and drugs, prevented dysplasia, cicatrical changes and skin malignisation around trophic ulcer.
4 cl, 1 ex
The invention relates to medicine, namely, laser medicine, and can be used for the treatment of trophic ulcers of venous etiology.
There are surgical methods for the treatment of venous ulcers, such as excision, vacuuming, curettage (Yablokov Mrs x, Kiriyenko A.I., Bogachev VY Chronic venous insufficiency. - M - 1999.- 128 C.). However, the result of these serious effects is slow reparative processes.
There is a method of treatment of venous ulcers using a variety of wound coverings (bogdaniec, L.N., Kiriyenko A.I., E.A. Alekseev Local treatment of venous trophic ulcers. The magazine "Gedeon Richter" in the CIS. - 2000.- No. 2. - P.58-60). The application of this method is limited by the development of local allergic reactions. You should also bear in mind the high cost of wound dressing.
The prototype of the present invention is a method of treatment of trophic ulcers, namely, that on the trophic ulcer impose a sterile bandage from dialdehydes containing the photosensitizer "photosense", and after keeping the wipes within 24 hours additionally carry out the irradiation of wounds red light emitted from the solid-state laser yttrium aluminate with twice the frequency and wavelength of 670 nm (patent RF №2164426 from the 27.03.2001, State research center of laser medicine MSRP). The disadvantage of this method is the need for long exposure headbands with photosensibilisation on the wound surface.
The technical result of the invention is an antimicrobial effect, improved neurotrophic regulation of affected tissues, improvement of rheological properties of blood, prevention of resistance microflora ulcers to antibiotics and drugs, prevention of occurrence of dysplasia, scarring and zlokacestvennoe skin around the sores.
This technical result is achieved due to the fact that in the treatment of trophic ulcers, comprising applying to the wound a photosensitizer and laser irradiation, the first surface of the ulcers and the skin around the ulcer is treated with air-gas stream containing nitric oxide is not less than 2000 ppm at a temperature of 40°With an exposure time of 10 seconds to 1 cm2after that as a photosensitizer is applied 0.1% gel Radachlorin dose of 0.2 g per 1 cm2the exposure time 60 minutes, then carry out the action of the laser light wavelength 0,665 μm at a dose of light energy of 150-200 j/cm2at a distance of 3-5 mm to the wound surface, then spend intravenous irradiation of blood through the cubital vein laser light wavelength 0,632 microns at a radiation power of 5 mW exposure 15 minutes, and the course of treatment, the Oia is 10 daily procedures for handling air-gas stream and intravenous laser irradiation of blood, 5-8 treatments of photodynamic therapy with an interval of 2 days. As a source of air / gas flow using the apparatus "Plason", as the source of laser light for photodynamic therapy using the apparatus "LAHTA-MILON, and apparatus for intravenous irradiation of blood use the apparatus Mustang-ILIB.
Treatment of trophic ulcers of venous etiology is as follows. The treatment is carried out sequentially. First ulcer surface is treated air-gas stream at a temperature of 40°C With nitrous oxide is not less than 2000 ppm (apparatus "Plason") exposure time 10 seconds on 1 cm2ulcer surface. Then, on the surface of the ulcers caused by the photosensitizer. As a last used by 0.1% gel Radachlorin for external use ("Radagel", 000 "RADA-PHARMA, Russia), which contains 1 mg/g of the active substance sodium salt of chlorin. Radagel applied on the entire ulcer surface with capture healthy tissue dose of 0.2 g per 1 cm2. After 60 minutes of exposure conducting photodynamic therapy laser light wavelength 0,665 μm at a dose of light energy of 150-200 j/cm2(apparatus "LAHTA-MILON"). The distance from the working end of the fiber to the wound surface 3-5 mm. After photodynamic treatment endovenous laser exposed the blood. The procedure is performed disposable quartz-polymer fibers in the cubital vein laser light of a wavelength of 0.63 µm, with output power of 5 mW (apparatus "Mustang-ILIB") and a duration of 15 minutes. Course NO therapy and intravenous laser irradiation of blood is 10 daily procedures. The number of sessions of photodynamic therapy for 5 to 8 with an interval of 2 days depending on the severity of inflammation and wound exudate.
The proposed method is illustrated by the following example.
Patient A. 52. Diagnosis: Chronic venous insufficiency complicated by trophic ulcers of both legs. Ill for 13 years. Treated inpatient and outpatient without any visible effect. In the lower third of both legs are trophic ulcers. On the right leg two ulcers dimensions of 5×6 cm and 3.5×5.5 cm, on the left leg one ulcer size 20×12 see Microbial infection of the ulcer surface 107microbial cells in 1 g of tissue. Patients received 8 sessions of photodynamic therapy with intervals of 2 days, NO therapy No. 10 daily. On the 4th day of treatment (2 sessions of photodynamic therapy and 4 session NO therapy) microbial colonization decreased to 105microbial cells in 1 g of tissue, which was accompanied by a significant decrease in discharge from the sores and swelling of the surrounding tissues. The patient notes that knowledge is sustained fashion decrease pain, normalized sleep. In parallel with the course of photodynamic treatment and NO-treatment patients received 10 sessions of intravenous irradiation of blood by laser with a wavelength of 632 nm. At the control examination after 2 months after starting treatment on the right leg there is one skin defect size 3×2 cm, on the left leg sizes 8×3, see the control examination after 6 months, no complaints. The skin of both legs without ulcers. Control examination after 12 months - no complaints, the skin of both legs without ulcers.
In this way treated 27 patients with a clinical picture of chronic venous insufficiency complicated by trophic ulcers. In all cases, was achieved this technical result.
The proposed method of treatment has a high antimicrobial activity, which reduces microbial contamination of the surface of ulcers, reducing the incidence of suppurative complications and do not require antibiotic treatment. Along with a significant decrease of pain syndrome, there are marked acceleration of the healing process. When this treatment is easily tolerated by patients and is performed on an outpatient basis.
1. Treatment of trophic ulcers of venous etiology, comprising applying to the wound a photosensitizer and laser irradiation, wherein the first surface of the ulcers and the skin around the ulcer is treated with air-gas stream containing nitric oxide is not less than 2000 ppm at a temperature of 40° exposure to 10 with 1 cm 2after that as a photosensitizer is applied 0.1%gel Radachlorin dose of 0.2 g per 1 cm2exposure 60 min, and then carry out the action of the laser light wavelength 0,665 μm at a dose of light energy of 150-200 j/cm2at a distance of 3-5 mm to the wound surface, then spend intravenous irradiation of blood through the cubital vein laser light wavelength 0,632 microns at a radiation power of 5 mW exposure 15 min, and the course of treatment is 10 daily procedures for handling air-gas stream and intravenous laser irradiation of blood, 5-8 treatments of photodynamic therapy with an interval of 2 days.
2. The method according to claim 1, characterized in that as the source of air / gas flow using the apparatus "Plason".
3. The method according to claim 1, wherein the source of laser light for photodynamic therapy using the apparatus "LAHTA-MILON".
4. The method according to claim 1, characterized in that in an apparatus for intravenous irradiation of blood using the apparatus "Mustang-ILIB".
SUBSTANCE: invention concerns medicine and claims therapeutic material and therapeutic media based on it for purulo-necrotic wound treatment, as well as method of obtaining therapeutic material. Material includes activated textile carrier with trypsin, insulin and lysocim immobilised in it.
EFFECT: significant reduction of wound surface cleaning time, accelerated healing.
17 cl, 2 tbl, 9 ex
SUBSTANCE: invention concerns medicine, particularly methods of specific bioactive substance extraction for obtainment of medication with wound-healing effect for small-area wounds which do not require primary instrumented surgical treatment, preferably at I, II healing phase. Method of obtaining medication involves mineral water processing by ethyl alcohol, sodium chloride (10-15%) and calcium oxide (5-10%), stirring for one day, decantation of salt precipitation, water and alcohol mix distillation, with further obtainment of target product in the form of water alcohol extract. Mineral sulfide water is neutralised to pH=7.0-7.5 after mineral salt extraction, and water and alcohol solution with ethanol content of 32% is distilled.
EFFECT: high output of bioorganic complex, production utilising accessible raw material from mineral sulfide water, such as Novonukutsk Matsesta.
SUBSTANCE: wastes of confectionery industry production, milled husk of cacao beans, are drawn in water at temperature 20°C for 2 hours with following extraction by hot water (80-90°C) in battery of four extractors, thickening of extract and drying are carried out.
EFFECT: extension of medication activity spectrum and decrease of power consumption.
SUBSTANCE: ointment for treatment of aphtae, wounds, containing 15% water solution of rivanol, milfoil infusion, eleutherococcus extract, 1% solution of chonsurid, 0.5% water solution of levamisole, tanian, 10% liniment of dibunolum, taken in definite ratio.
EFFECT: said ointment is effective for treatment of aphtae, wounds, burns.
SUBSTANCE: described is protective product for wounds, which includes substance, inhibiting bacterial growth in wounds. Invention is characterised by the fact that it is xylite. Invention also relates to xylite application in protective products for wounds and to xylite application for obtaining composition, which has effect of inhibiting bacterial growth in wounds. Invention also relates to method of producing protective xylite-containing products for wounds.
EFFECT: product for wounds considerably improves possibility of infected wounds treatment.
38 cl, 5 dwg
SUBSTANCE: invention relates to medicine and can be used in experimental and clinical surgery, traumatology for application of film-forming compositions on wound surface. Described is medicinal composition based on medicinal preparation and BF-6 glue where as medicinal components are used xymedone, ximedone hydrochloride, dimexide, dioxydin, lidocaine hydrochloride or xymedone, brilliant green, lidocaine hydrochloride or xymedone, methylene blue, lidocaine hydrochloride or ximedone hydrochloride, potassium permanganate, lidocaine hydrochloride.
EFFECT: glue bandage prevents from external influence, contamination, stimulates formation of strong soldered layer and epithelisation.
5 cl, 1 tbl, 12 dwg , 5 ex
SUBSTANCE: invention refers to medicine and pharmacology, namely to pharmaceutical composition applied for external and local treatment of pyodestructive processes in skin and mucous membranes and characterised by that it contains Tilorone and at least one end additive chosen from: agent with antibacterial activity to gram-positive and/or gram-negative bacteria, antimicotic, local anaesthetic agent, reparative stimulator, hypooxidant, biogenic elements, a base or their mixture in certain ratio.
EFFECT: invention ensures extended application of the known active agent Tilorone, restored local immunity and biocoenosis of skin and mucous membranes in treatment of pyodestructive processes, anaesthetic effect; additional reparative stimulation; improved microcirculation in lesion focus, reduced inflammatory reactions in skin and mucous membranes, decreased secondary tissue neurosis of the affected areas, improved microcirculation in lesion focus, reduced itching, maintained high therapeutic activity and usability, more rapid and improved healing.
10 cl, 19 ex
SUBSTANCE: invention concerns medicine and pharmacology, namely, pharmaceutical composition applied at treatment of purulent-destructive processes of a skin and mucosas at external and local application, characterised that it contains tylorone, an emulsion of perfluoroorganic bonds, and as, at necessity, a hydrophylic basis at a certain parity of components.
EFFECT: invention provides expansion of a scope of known active substance - tylorone, restoration of tissue immunity and biocenosis of a skin and mucosas at treatment of purulent-destructive processes of a skin, depression of a secondary necrosis of tissues on the amazed sites, microcirculation improvement in the lesion centre, cupping of inflammatory reactions, reduction of an itch maintenance of high therapeutic activity and convenience in use, acceleration and healing improvement.
19 ex, 4 cl
SUBSTANCE: invention relates to field of medicine, namely to remedy and method of obtaining remedy for wound treatment. Method of obtaining remedy for wound treatment lies in the following: from fly eggs larvae are gown, which can be introduced in to wound under treatment, larvae are contaminated with bacteriophages in such way that introduced larvae are bacteriophage carriers. In order to realising said method, in particular, larvae of genus Lucilia are used. Also claimed are method and remedy for wound treatment, with tampon containing bacteriophages and soaked with larva secret on wound.
EFFECT: treatment of wounds with fly larvae is improved by contamination of larvae with bacteriophages.
SUBSTANCE: invention relates to medicine and pharmacology and represents pharmaceutical composition for treating purulent destructive lesions of mucous membrane and skin, characterised by containing tilorone mixed with soft formable base, where as soft formable base it contains hyperosmolar substances selected from group.
EFFECT: invention ensures recovery of local immunity and biocoenosis of skin and mucous membranes in case of purulent destructive skin processes, reduction of secondary tissue necrosis on affected sections, high therapeutic activity and convenience in use.
7 cl, 19 ex
FIELD: medical equipment.
SUBSTANCE: invention concerns medical equipment and can be applied in cancer tissue treatment in various organs of biological objects. Device includes semiconductor laser diode, clock generator, semitransparent mirror, comparator, first, second and third direct current amplifiers, differentiating amplifier, discriminating amplifier, first and second photo receivers, delay line, analog to digital converter, programmed permanent memory, first and second binary code comparators, first and second control systems of secondary power sources, first and second secondary power sources and light panel/indicator. Biological object is positioned in line between semiconductor laser, semitransparent mirror and second photo receiver.
EFFECT: extended range of technical devices for laser cancer therapy.
SUBSTANCE: invention refers to medicine, namely to laser therapy. The first stage of the therapy involves introduction of medicines and intravenous laser blood exposure by installing a needle in one solution transfusion system for quartz fibre of diametre 0.7 mm through which the patient is exposed to helium-neon laser of power 1.2 mW at exposition 90 minutes within seven daily procedures. The second stage includes paravertebral block within herniated disk localisation in projection of herniated disk. Quartz fibre of diametre 0.7 mm is introduced through a puncture needle to the level of surface musculofascial layer. Injection of solution is immediately followed with irradiation with helium-neon laser of power 1.2 mW at exposition 80 minutes within seven daily procedures. Medicines within solution transfusion system are as follows: Trental 5 ml, Actovegin 5 ml, 15% Xantinol Nicotinate 2 ml, vitamin B1 2 ml alternated with vitamin B6 2 ml, 5% vitamin C 3 ml dissolved in physiologic saline 150 ml. Paravertebral block of the first day includes 5% glucocorticoid Diprospan 1 ml combined with 2% Lidocaine. For the following days 2% Lidocaine is used.
EFFECT: method allows terminating inflammatory process, ensuring stable pain management.
SUBSTANCE: therapy of secondary lower limb lymphodema refers to medicine, namely to clinical lymphology. The oatient is exposed to laser light of wavelength 0.6328 mcm combined with intravenous laser irradiation of power 1.2 mW and exposition 90 minutes and intravenous introduction of medicine solutions: Trental, Actovegin, Pheopolyglukine, vitamin B, C complexes, 0.15% xantinol nicotinate. Procedures are daily at seven procedures per course.
EFFECT: therapy provides stable reduction of secondary lower limb lymphodema without therapeutic by-effects, prevents recurrence.
2 cl, 2 ex
SUBSTANCE: invention refers to medicine, to neurology. The therapy involves taking the medicines improving cerebral blood circulations. Pharmacotherapy is combined with exposure to laser light within anconeus and popliteal fold regions. Laser puncture covers the points VB 20 and VB 21 symmetrically downright. Laser light is characterised with wavelength 0.89 mcm, power 3 mW and frequency 600 Hz. Herewith light exposure is 1 minute per each point and 2-3 minutes per elbow and popliteal folds. Therapeutic course is 10 days twice every second month.
EFFECT: method reduces treatment time.
3 ex, 1 tbl
SUBSTANCE: invention relates to medicine, oncology, surgery, radiology, physical therapy and can be used for treating patients with larynx cancer. Area of radiation and surrounding tissues is exposed to infrared laser irradiation. From first day of radioreaction diagnostics, exposure to infrared laser irradiation with constant magnetic field with magnetic induction intensity within 20 mTa, recurrence frequency of pulse laser irradiation of infrared spectrum within 80 Hz, power 0.5-1.0 W on all zone of irradiation is performed with defocused ray for 30-120 seconds. Course includes 3-8 procedures with further application on irradiation zones and intake of a teaspoon of cedar nut oil and before going to bed daily during the whole course of radiation therapy.
EFFECT: method allows to increase efficiency of treatment of early radioreactions and prevent development of later radiation damage reducing severity and frequency of their development.
SUBSTANCE: invention relates to field of medicine, namely to ophthalmology. Laser stroboscopy is carried out during 5 days, 2 times a day with 1 hour interval. First 10 minutes each eye is influenced in turn, then for 5 minutes both eyes are influenced simultaneously. Distance to speckle is 1 m.
EFFECT: recovering binocular functions with elimination of anisoaccomodation, enhancing binocular interaction, increasing visual acuity.
3 cl, 2 ex
SUBSTANCE: invention refers to medicine and aims at epilepsy management. Carotid and vertebral arteries are sequentially exposed to IR laser light, infra-red laser radiation to the right and to the left each for 5 minutes. Frontal, temporal, parietal and occipital lobes are exposed to magnetic field and microwave radiation to the right and to the left each for 3 minutes. And visual analyser is exposed to IR waves within 30 minutes. It is combined with electroencephalographic training with course of treatment 15 procedures.
EFFECT: disclosed method allows for improved mental measurements, relieved remove proneness to convulsive activity, suppressed epileptogenic zones, improved metabolic and energy cerebral processes, normalised cerebral blood flow regulation, recovered cortical neurodynamic disorders.
SUBSTANCE: invention refers to medicine, oncology and to be used for neoadjuvant chemoradiotherapy in the patients suffering from thoracic oesophagus cancer. Said therapy is ensured by introduction of cisplatin and leucovorin, and continuous intravenous infusions of fluorouracil dosed 300 mg/m2. Cisplatin solution is introduced intravenously drop-by-drop and dosed 6 mg/m2 daily once a day within 1 hour. Leucovorin is injected intravenously jet-like and dosed 30 mg/m2. Radiotherapy involves daily fractions 3 Gy to total basic dose 30 Gy. The course dose of fluorouracil is 3600 mg/m2, of cisplatin is 72 mg/m2, of leucovorin 360 mg/m2. Chemotherapy and radiotherapy are to be started the same day.
EFFECT: disclosed method allows for considerably reduced toxicity of treatment to be continuous, treatment of the patients originally of bad performance status, for doubly reduced time of neoadjuvant treatment with maintaining high clinical effectiveness.
SUBSTANCE: invention refers to medicine, urology, physiotherapy and to be used in the patients suffering from chronic pyelonephritis accompanied with chronic prostatitis and chronic cystitis. The method involves taking the mineral water of the Slavjanovsky source dosed 3 - 5 ml per kg of body weight, combined with carbonic mineral baths 35-37°C for 15 minutes 3 times a day, № 8-10, mud "panties" at 40-42°C within 30 minutes to 1.5 hours, prostate massage № 8-10, additionally 50-60 minutes later followed with electropulse therapy combined with exposure to laser magnetic rays. Electropulse therapy involves low-frequency, low-voltage pulse current with a spherical unipolar electrode. Exposure is contact, labile, clockwise and located at skin projection of ascending, transverse and descending large intestine at frequency 30.2 Hz within 8-10 minutes. The course of treatment is 10-12 procedures.
EFFECT: method improves life quality of the patients both in latent phase of inflammatory process, and in mild and moderate active chronic process.
2 ex, 2 tbl
SUBSTANCE: invention concerns ophthalmology and is intended for treatment of infectious diseases of a cornea. Photodynamic therapy with the use of gel containing an octacation phthalocyanine of zinc in concentration of 1-3 mg/ml, which is applied on a cornea as a photosensitinogen, is performed. The conjunctival cavity is washed out after 30 - 40 minutes and influenced with a laser radiation with a wavelength of 675 nm with a light dose 20 - 60 J/cm2 in of 5 minutes, once a day. 1-8 sessions during each course.
EFFECT: method allows destroying the originator of keratitis in a cell with the maximum safety of surrounding tissues of the cornea.
2 tbl, 3 dwg, 1 ex
SUBSTANCE: invention refers to medicine and biochemistry and concerns method for making a chewing product for enamel remineralisation including the stages as follows: a) preparation of aqueous solution of at least one acidifier, e.g., chosen from the group including carboxylic acids and fruit acids; b) addition of reaction calcium source; c) mixing the solution with a thickener representing gelatine; d) thorough agitation of the components for product preparation; e) extrusion and drying of the product characterised that at least at one stage phosphoric acid is added.
EFFECT: invention ensures a transparent and homogeneous gelatine chewing product with high calcium and phosphate concentration for remineralisation.
7 cl, 5 ex, 1 dwg