Wound- healing ointment

FIELD: medicine.

SUBSTANCE: ointment for treatment of aphtae, wounds, containing 15% water solution of rivanol, milfoil infusion, eleutherococcus extract, 1% solution of chonsurid, 0.5% water solution of levamisole, tanian, 10% liniment of dibunolum, taken in definite ratio.

EFFECT: said ointment is effective for treatment of aphtae, wounds, burns.

2 ex

 

The invention relates to medicine, namely to medicines, made in the form of ointment for local application - treatment of injuries of ulcers, wounds, burns.

Known a number of tools for local use - treatment of injuries of ulcers, wounds, burns (patent RU №1805952, IPC AC 9/06, 1993, patent RU No. 2274456 C2, IPC AC 9/06, 2004) [1, 2].

The disadvantage of these ointments is the narrow range of therapeutic actions, mainly antimicrobial orientation. They have limitations because of their individual intolerances, as well as the risk of development of side effects with long - term use to reduce the sensitivity of microflora, dysfunction of the internal organs.

As the closest analogue adopted ointment for the treatment of burn wounds (patent RU №2287324 C1 IPC AC 9/06, 2005), containing vegetable oil, wax, rivanol, tannin, glycerin [3]. This ointment because of the wax-oil-glycerin mixture has a high penetration in the tissue, plastic, has a high healing effect.

However, used as one of the main ingredients of beeswax contraindications available, in addition, the ointment does not stimulate immune system of the body, not inhibits free radical reactions in the wound, which causes slow wound healing effect, recurrent Zabol the cation and related allergic reactions.

Tasked with creating a highly effective wound healing anti-inflammatory, immunomodulatory, antibacterial and local anesthetic ointment with pronounced clinical effect and broad functionality.

The problem is solved by introducing into the composition an ointment containing 15%aqueous solution rivanol, components of medicinal plants, tannin and ointment base, infusion of yarrow, extract of Siberian ginseng, a 1%solution of concorida, a 0.5%aqueous solution of levamisole as ointment bases - 10% liniment dibunola, in the following ratio, wt.%:

The solution rivanol1,5-2
Infusion of yarrow2-5
Extract of Siberian ginseng1-3
The solution honoured4-6
The solution of levamisole8-10
Tannin1-3
Liniment dibunolaRest

The parameters you enter in the composition of the claimed ointment components was determined by the op is Tim way. Introduction components below the lower or above the upper limit does not provide the optimum therapeutic effect, and General appearance.

Characteristic components of the wound healing remedy.

15%solution of rivanol provides antibacterial action, infusion of yarrow extract and Siberian ginseng have anti-inflammatory, adaptogenic and stimulating the enzymatic activity of the tissue effect. 1%solution of concorida provides improved tissue metabolism, stimulates metabolic processes, a 0.5%aqueous solution of levamisole stimulates modulating the processes of the immune system (immuno-modulating action). The use of tannin causes the effect of dehydration that can protect inflamed tissue from damaging factors. Tannin has anti-inflammatory and local anesthetic effect. 10% liniment dibunola has an antioxidant effect. BHT is a cytostatic agent, it inhibits free radical reactions, and has powerful antioxidant properties [4].

Comparative analysis with the prototype showed that the proposed composition of the ointment is different from the known to the introduction of new components, namely infusion of yarrow, extract of Siberian ginseng, a 1%solution of concorida, a 0.5%aqueous solution of levamisole, 10% liniment, Debono is the new ratio of components.

The analysis of the known ointments, similar to the claimed ointment on the spectrum of therapeutic action, showed that the composition: 15%aqueous solution rivanol, infusion of yarrow extract, Siberian ginseng, 1%solution of concorida, a 0.5%aqueous solution of levamisole, tannin, 10% liniment dibunola, in which all the ingredients are soluble or shared with liniment dibunola, in practice, treatment of the aft, wounds and burns has not previously been used.

A wound healing agent is prepared as follows.

The calculation is shown in 100 kg of product. For example, 100 kg of 10% liniment dibunola brought to a boil in a steam bath, after which it add the infusion of yarrow (2 kg) and extract of Eleutherococcus (1 kg), and then the solution rivanol (1.5 kg). The resulting mass is stirred for 45 minutes, cool, add dissolved in 1%solution of concorida (4 kg) and 0.5%aqueous solution of levamisole (8 kg) tannin (1 kg) and again thoroughly stirred for 45 minutes. The resulting mixture was again heated on the steam bath to 70°C, then remove from fire, cool and filter through a double layer of sterile gauze.

When cooking under the influence of successive heating, cooling and mixing creates this balance of medicinal substances, which allows to achieve the desired wound healing anti-inflammatory, immunodeficiency, modeliruyushchego, antibacterial and local anesthetic effect. The proposed solution allows to obtain a inexpensive, cost-effective wound healing agent with high efficiency in a wide range of diseases involving damage to the mucous membranes and skin, and also to shorten the time of treatment.

Example 2. Composition, kg:

The solution rivanol2
Infusion of yarrow5
Extract of Siberian ginseng3
The solution honoured6
The solution of levamisole10
Tannin3
Liniment dibunolaRest

The method of preparation of the ointment of example 2 similar to example 1.

Ointment of example 1 should be used when damage to the mucous membranes, including the oral mucosa of the mouth, lips, ointment for example 2 - if wounds and skin burns. Shelf life proceeds are not less than 1 year. The options in the tool stable during storage. The tool is the Wallpaper light yellow mass with a pleasant herbal smell.

The claimed healing ointment is a very flexible, easy to apply on the skin and mucous membranes, has a high penetration in the tissue. Ointment stimulates the immune power of the body, harmless and has no side effects.

Therapeutic effect of the proposed drug tested throughout the range of the quantitative content components. Complications and side effects when using this tool have been identified. The method of applying the funds to the mucous membrane of the mouth simple, accessible. The tool is captured well even on wet mouth. All components of the proposed drug are of natural origin, without chemical additives. This breadth of use due to the medicinal value of the funds due to the optimal combination of its biologically active substances.

Examples of specific performance.

Example 1. Patient K., age 11, AMB. map No. 221037. Diagnosis: Burn the mucous membranes of the mouth and lips 1-2-th degree (boiling water). Wounds daily smeared declare healing tool for 6 days. Ulcers epithelialize on the 2nd day of treatment, after 6 days after treatment with the ointment, the patient fully recovered the lips and mucosa of the oral cavity.

Example 2. Patient S., aged 35, AMB. map No. 120891. In the mouth: atty lower lip, Resina in the corner of the mouth, covered with yellow fibrinous plaque. Diagnosis: Chronic meteorological cheilitis. According to the patient, used them wound healing ointment effect to no avail.

Treatment. The designated use of the claimed ointment. After 3 days showed complete epithelialization of the aft and cracked lips.

Example 3. Patient U., 39 years old, AMB. map No. 221408. Addressed with burns of the upper extremity 2-3 degrees. After applying the ointment recovery occurred after 12 days.

Example 4. Patient K., age 16, AMB. map No. 109871, appealed with complaints about non-healing burn of lower limb 2 degree caused sea jellyfish. The disease duration of 3 days. Used wound healing agent effect to no avail.

The patient is assigned to the claimed ointment. After applying the ointment recovery occurred after 4 days.

Example 5 (prototype). Patient C., 56 years, AMB. map No. 107663, appealed with complaints about frostbite of the extremities. The patient is suffering from diabetes of the 1st type. Treatment. Assigned applications ointment prototype. After 3 days of application prototype ulcer size decreased slightly, constantly bleeding. The patient is recommended to start using the claimed remedy. After the start of use of the proposed drug, the patient noted a decrease in pain in the wounds. Already on the 2nd day after the start of treatment designed environments is the your treatment gave a positive result, the pain was gone, the swelling has decreased considerably. On the 4th day the ulcer epithelials, on the 12th day has cured, healed the wounds with a gentle scar tissue.

Obtained in the clinic data suggest that developed wound-healing, anti-inflammatory, together with immunomodulating, anti-bacterial and local anesthetic ointment as a highly effective means of treating the aft, wounds and burns, with pronounced clinical effect and broad functionality for practical medicine.

Ointment for the treatment of the aft, wounds, burns, containing 15%aqueous solution rivanol, components of medicinal plants, tannin and ointment base, characterized in that it further contains an infusion of yarrow extract, Siberian ginseng, 1%solution of concorida, a 0.5%aqueous solution of levamisole, 10%liniment dibunola in the following ratio, wt.%:

the solution rivanol 15%1,5-2
infusion of yarrow2-5
extract of Siberian ginseng1-3
the solution concorida 1%4-6
water is actor of levamisole 0.5% 8-10
tannin1-3
liniment dibunola 10%rest



 

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