Medicinal composition (versions)

FIELD: medicine.

SUBSTANCE: invention relates to medicine and can be used in experimental and clinical surgery, traumatology for application of film-forming compositions on wound surface. Described is medicinal composition based on medicinal preparation and BF-6 glue where as medicinal components are used xymedone, ximedone hydrochloride, dimexide, dioxydin, lidocaine hydrochloride or xymedone, brilliant green, lidocaine hydrochloride or xymedone, methylene blue, lidocaine hydrochloride or ximedone hydrochloride, potassium permanganate, lidocaine hydrochloride.

EFFECT: glue bandage prevents from external influence, contamination, stimulates formation of strong soldered layer and epithelisation.

5 cl, 1 tbl, 12 dwg , 5 ex

 

The invention relates to medicine, namely to pharmaceutical compositions for the treatment of wound surfaces of the polymer adhesive film-forming compositions.

Despite the age-old experience gained when using the mankind bandages to treat wounds, many issues of this important ageless medical issues remain unresolved.

The inadequacy of local therapy of wounds with various coatings, including adhesive, the greatest concern was the increase in the frequency of infectious postoperative wound complications. Developing purulent-inflammatory processes in the area of RAS greatly reduce the quality of treatment of patients, increase the time spent in a hospital [Postyshev VK Operational purulent surgery. M.: Medicine, 1996; Izmailov A.C. et al. The treatment of wounds. Kazan: Kazan state technological University, 2003].

Providing a favorable climate in the wound is not complicated flow of the biological process, the implementation of the organism functionally complete true regeneration or repair of damaged tissue is achieved the individual treatment program the treatment and stroumsa with the obligatory account of objective data obtained during examination of the patient, followed by carrying out the following main activities:

- clarification and evaluation SEEIT is Ogii wounds, her timing, localization and vastness homeostasis and age of the victim, the presence of background pathological conditions and concomitant injuries;

- conducting elements of classical, mechanical and physical antiseptics (excision, drainage, etc.);

- the inclusion of promising measures aimed at the prevention of secondary contamination;

- wound closure by applying secondary sutures or skin plastic surgery.

In treatment one of the most important components are wound dressings with different properties. New advances in the treatment of wounds has allowed the formation of a graded approach, based on the phase currents of the wound healing process. In bandage problems include the main functions: protection from adverse external influences and secondary ingress of microorganisms, stimulating cellular activity. Well-known used the popular soft band of textile (gauze fabric), non-woven (combined with a filler made of cellulose or foam rubber and other materials, which have a number of fundamental requirements: to debug a specific absorption and suction ability, to have sufficient permeability to gases, necessary regulation balanced humidity and maintaining a free exchange of gases, which determines the desired concentration O 2, CO2and the pH level; to be noninvasive and safe. In recent years, increasing the flow of wound dressings for dry (EU-dressing, "Catovic", "Cosmopol sterile" and others) and wet (Tenderwet" and others) treatment of wounds [Adamyan A.A., Dobysh SV, Klimchuk LE and other Biologically active dressings in treatment of purulent-necrotic wounds. Method recommendations. Edited exchanged her experience and IMIA. M, 2000, 39; Lippert H. guidelines for the treatment of wounds. Ed.: .Hartmann, 2000].

Classic soft headbands have significant benefits for local treatment of wounds healing by second intention (per secundam intentionem)and old (over 6-8 h) open wounds and tissue damage with the initial guess of the possible Genesis of primary infection. In cases where this risk is small, which occurs when uncontaminated pure random and operating stripes with hope for their spontaneous epithelization, the use of different soft bandages impractical. The latter is explained by a number of their major drawbacks:

the relative complexity of the design; the long duration of the overlay (from 8 to 15 min);

- high mobility especially swathe species, which narrows the indications for their use. So, not recommended for use on areas such as the face, neck, joints, outdoor sex male and female bodies is s, crotch;

will not strengthen the contact edges of the wound. Insufficient fixation does not create a complete physiological rest damaged tissues, being at the same time limiting, the limiting factor of an active functional therapy;

- impossible continuous monitoring of wounds without changing the dressing material;

- economiccost due to the large consumption of the dressing material;

- there is a high risk of nosocomial infection due to subsidence and the accumulation of dust from the presence of pathogenic microflora;

- adsorption of microbes on the surface of the wound greatly increases the risk of Genesis anaerobic infections.

The same deficiencies in varying degrees as they have swathe and bezvintovyie (colloidal and claravia, leukoplasia) dressing.

The spread was also polymeric film - and foaming agents used for "open" doing clean wounds in the postoperative period and in aseptic microtraumas. They have the best prospects of healing by primary intention (per primam intentionem). When hemostasis loose fibrin, albeit unsteadily, temporarily glue the edges of the wound, and the severity of exudative (inflammatory) phase is negligible. After drying, the adhesive is formed of an elastic film which does not require additional dressing. To the paints of what you adhesive bandages include easy and fast application [Petrov S.V. General surgery. SPb.: Publishing house "LAN", 1999].

One example of such bandages is a medical adhesive (EN) 2156140 (13) C1 7 A61L 24/00, C09J 4/04 having low mechanical strength and low resistance to biological environments - wound inflammatory exudate, poor regenerative capacity and severe acute segmental-nuclear reaction with a prominent vascular component. The inflammatory reaction is particularly high in the skin and muscle, greatly reduces the value of practical therapeutic application of such compositions in the treatment of surface wounds.

The provision of active influence on the course of regeneration is achieved only through adequate regulation of a favorable microclimate in the area of tissue damage in certain phases of healing, local use of pharmacological agents with different properties. Known composition based on ligfola and novocaine [RF patent №2272640, publ. 2006.03.27]. The downside of it is the need for daily application on the wound. The composition is also effective when Pseudomonas infection, devoid of observable properties induce tissue regeneration processes, is not conducive to the deep penetration of drugs into the damaged tissue. "Ligfola", which consists of humic acid (hydrolysis product of natural wood lignin) has allerge the activities that narrows the indications for its use. Novocaine has a weak local anesthetic qualities.

Known adhesive composition Caliber" [Izmailov A.C. et al. The technique of blending soft bandages. Nizhny Novgorod - Kazan, 2004, p.71-72. RF patent №2188016, publ. 27.08.2002,], taken as a prototype of the invention containing the following ingredients in wt.%:

Ksimedon5,0-10,0
Benzocaine4,0-5,0
Hemisuccinate hydrocortisone0,09-0,13
Boric acid3,0-4,0
Glue BF-6rest

Experience shows that the prototype along with significant advantages has several significant disadvantages, for example:

- benzocaine does not have a sufficiently high analgesic effect and often on its application meets individual hypersensitivity;

- hemisuccinate hydrocortisone relatively expensive drug, as well as glucocorticosteroid, has extensive contraindications, for example, the presence of infection in the wound has viriliziruyuschim side de is due, hyperglycemia exacerbates the course of peptic ulcer of stomach and duodenum, increases blood clotting and many other undesirable actions;

- boric acid difficultly soluble, often increases pain syndrome, which limits its use, for example, in children.

The objective of the invention is the creation of a therapeutic agent, devoid of the above disadvantages and extends the known range of pharmaceutical compositions.

The technical result - the new drug (versions).

With the aim of increasing Arsenal of pharmaceutical compositions and impart adhesive composition based glue BF-6 is more pronounced regenerative abilities, as well as antiseptic and anesthetic properties, proposed several options (1-5) new pharmacological adhesive compositions in the following ratio of ingredients, wt.%:

1. ("Hexidine")

Hydrochloride Ximena- 8,0-10,0
Dimexide- 28,0-30,0
Dioxidine- 0,8-1,0
Lidocaine hydrochloride- 9,0-10,0
Glue BF-6the rest of it.

2. ("Oxidixed")

Ksimedon- 8,0-10,0
Dimexide- 18,0-20,0
Dioxidine- 0,8-1,0
Lidocaine hydrochloride- 9,0-10,0
Glue BF-6the rest of it.

3. ("Nsibilit")

Ksimedon- 6,0-6,5
Brilliant green- 1,8-2,0
Lidocaine hydrochloride- 9,0-10,0
Glue BF-6rest

4. ("Ximately")

Ksimedon- 6,0-6,5
Methylene blue- 1,8-2,0
Lidocaine hydrochloride- 9,0-10,0
Glue BF-6rest

5. (Lexicale")

Hydrochloride Ximena- 8,0-10,0
Potassium permanganate- 0,2-0,4
Lidocaine hydrochloride- 9,0-10,0
Glue BF-6rest

Presents the ratio of the components based on data from long-term own clinical and experimental research, taking into account the available literature data [Kurmangaliev S.M. Purulent infection in surgery. M.: Medicine, 1985; konichev A.V. Purulent-inflammatory diseases of the upper constant. SPb.: Nevsky Dialect" 2002; Podushkin IV topical application of Ximena and photomagnetism to ensure long-term healing of wounds and ulcers in an outpatient surgical practice military doctor: author. Diss. Kida. the honey. Sciences. N.Novgorod, 2000; Mashkovsky PPM Pharmacological tools. M.: Medicine, 2004].

Ksimedon (Ximedonum) and hydrochloride Ximena (Hydrochloridum Ximedoni) have polyvalent action, which should be particularly emphasized the stimulation of regenerative processes in the damaged tissues. In the surgical clinic and animals studied reparative ability, antiseptic, antisense properties and the safety of their local PR the changes. Installed the effectiveness of both in monotherapy and in combination with other drugs (dioxidine, lidocaine and others) with some variation in the impact phase of inflammation. Hydrochloride Ximena has a strong dehydrating effect, which makes it expedient in the case of prevalence of the tissue edema [Patent RU 2261699, publ. 10.10.2005,].

Dimexide - Dimexidum (dimethylsulfoxide - DMSO) is a chemical antiseptic and oxidizing agent, endowed with anti-inflammatory, analgesic, and desensibilisation properties, and also has a very important ability to transport into tissues other drug substances such as ksimedon and hydrochloride Ximena. In connection with what is potentiation of their actions, due to the penetration formamidine derivatives deep into the tissue through the cell membrane, which is confirmed by our observations.

Dioxidine (Dioxydinum) is known as a drug with wide spectrum used in various inflammatory processes in the form of solutions and ointments, but when alone possible side effects (diarrhea reactions, fever, headache). Undesirable listed responses are not observed when using the drug, we offer drug composition, not reducing it in the main antimicrobial action.

Lidocaine (Xylocain, Xican) hydrochloride (Lidocaini hydrochloridum) as local analiziruyuschei means in the form of a solution used for infiltration and terminal anesthesia. Isolated use of the drug often leads to dermatological reactions (hives, skin rash, and others), which is not observed when incorporating it in our proposed composition. You should consider antiarrhythmic property of the drug [Mashkovsky PPM Pharmacological tools. M.: Medicine, 2004].

The inclusion of dye - methylene blue (Methylenum coeruleum) and brilliant green (Viride nitens) and a strong oxidant is potassium permanganate (Kalii permanganas) made to enhance the adhesive composition antiseptic properties. Giving a composition of color allows more rational to use it with a small surface damage when you require strict localization of the preparation in the absence of the need for permanent monitoring of patients, for example, in an outpatient setting.

In the present invention proposed a number of medicinal adhesive compositions for the possible implementation of a new individualized approach to the treatment of wounds, based on modern criteria dressing devices, depending on the etiology, extent of damage, extent of infection, and e is sudachi.

Mainly used stage of wound process: exudation, granulation, epithelialization. This approach allows maximum efficiency of use of the proposed interactive dressings in the daily practice of a physician, obtaining good results.

EXAMPLE 1 (components in wt.%)

Hydrochloride Ximena- 9,0
Dimexide- 29,0
Dioxidine- 0,9
Lidocaine hydrochloride- 9,5
Glue BF-6- rest

Patient S., aged 47, arrived in septic Department with extensive mechanical random wound left buttocks. The body temperature of 40°C. On the background of common complex therapy topically applied bandage with an adhesive composition (option 1). The wound on day 8 was purified from purulent-fibrinous deposits. Complete healing occurred on the 10th day after imposition of secondary early seams.

EXAMPLE 2 (components in wt.%)

Ksimedon- 9,0
DIMEX is d - 19,0
Dioxidine- 0,95
Lidocaine hydrochloride- 9,0
Glue BF-6- rest

Patient C., 40 years old was admitted to the surgical Department 2 hours after the onset of the disease. During the inspection it was noted signs of acute adhesive obstruction. A year ago he was operated on for a closed abdominal trauma. Urgently made laparotomy with dissection meritline adhesions, median postoperative wound injury overlay adhesive compositions (option 2) of the present technology. Wound healing by first intention.

EXAMPLE 3 (components in wt.%)

Ksimedonto 6.2
Brilliant green- 1,9
Lidocaine hydrochloride- 10,0
Glue BF-6- rest

Patient S., aged 26, was treated in an outpatient setting with a superficial wound in the chin area without signs of suppuration. Skin defect 3×1.5 cm closed adhesive composition variant. Uncomplicated healing for 8 days.

Example 4 (components in wt.%)

Ksimedon- 6,0
Methylene blue- 1,9
Lidocaine hydrochloride- 9,0
Glue BF-6- rest

Patient G., 21, enrolled in outpatient treatment with a diagnosis of incised wounds of the right forearm. Wound with smooth edges sutured with nylon because of its localization and additionally applied composition option 4. Sutures were removed on the 6th day, healing by first intention.

EXAMPLE 5 (components in wt.%)

Hydrochloride Ximena- 10,0
Potassium permanganate- 0,3
Lidocaine hydrochlorideand 9.8
Glue BF-6- the rest.

The patient is 76 years old, was admitted to the surgical Department with purulent-necrotic wound of the right thigh. Suffering from diabetes. The wound does not heal for 2 months, although they used different ointment run the I. Assigned to combined therapy with correction of carbohydrate metabolism. Topically applied bandages variant composition 5. Slow healing by second intention.

Clinical application of the inventive compositions showed that there was an increase breathalyse and adhesive, desensitizing and regenerative abilities. Found not additive activity of the proposed combination, and synergene action - effect greater than the sum of effects of individual components, which is likely due to the potentiating effect of ingredients on various aspects of the metabolism of microbes, proliteracy cells, angiogenesis and other growth factors and cellular processes involved in wound healing. The composition of its pharmacological properties provide optimum conditions for uncomplicated repair of damaged tissues in all its phases, as confirmed by the results given in table 1.

In table 1 the results of the use of the claimed medicinal compositions (options 1-5) in the treatment of wounds depending on the clinical syndrome in comparison with the prototype composition Caliber.

The process of making the proposed composition is carried out according Sobyanin methods of the State Pharmacopoeia simply mixing the components [Reference pharmacist / edited Aiemchawee. - M.: Medicine, 1973. 584 S.].

Caliber (composition of the prototype) is applied to the wound through her lubrication, for example, a brush or swab, which leads to unnecessary additional trauma to the tissue. In addition, this technology does not guarantee achievement the totality of treatment the wound surface and parabolani area. There is also a high risk of implant infection due to separation of the fibers of the brush to carry them into the wound. Thus, it is reasonable to seek the improved technology applied on the wound adhesive composition.

A device for applying medicines, which includes a housing with an opening, the internal cavity of the housing is filled with a porous capillary material is impregnated with the liquid drug, and the hole is installed with the possibility of linear movement and fixation due to friction-clutch housing capillary rod, one end in contact with a porous material inside the housing, and the other protruding out of the housing [EN 2042362 C1, 1995.08.27].

A device for applying pastes and gels on hard-to-reach areas of the body that contains the capacity installed in her flexible shell forming a cylindrical cavity, a nozzle, a compressed gas and a locking device with a channel, soy is Inaudi pneumopathy and the atmosphere, in which a flexible membrane attached by one edge to the bottom base of the vessel circumference, and the other to the exterior surface of the compressed gas. When this nozzle is installed between pneumatology and a cavity formed by a flexible sheath and compressed gas [EN 2185200 C1, 2002.07.20].

A device for coating the surface of the skin or wound, comprising a housing which contains a means for supplying a jet of a solidifying liquid, and which contains the optical system providing the desired degree of solidification of the liquid [EN 2002122705 AND 2004.03.10].

A device for coating the surface of the skin or wound, formed from the streams of solidified fluid, comprising a device for jet formation, equipped with a capillary tube, the source of high electrical voltage and device for creating a focusing electrostatic field around the jet, made in the form of an electrode placed around the axis of the capillary in the vicinity of its outlet opening, while the capillary and the electrode connected to the source of high electrical voltage, one pole of which is intended for electrical connection with the body of the patient [EN 2002122705 AND 2004.03.10].

However, these devices are complicated and inconvenient in operation. These shortcomings have devices the [RU 2006111484 AND, 2004.08.10, EN 2002107499 AND 2003.11.27].

Known application for applying to the wound adhesive compositions of special devices in the form of a spray (Akuten", "Nobukata", "Aeroblast", "Acutal" and the like), where the adhesive is under pressure from 1.5 to 5 ATM. The device consists of a casing in the form of a spray with a mixture of the drug with liquefied gas and spray heads. By clicking on the last evolves gaseous phase filler and dispersed adhesive stream is emitted to the outside.

Known applicator comprising a container for storing liquid, hygroscopic swab, means fixing the absorbent pad against the exit port of the liquid from the container, and means fixing rollers are integral with the canister and made in the form of arches, carrying a tampon. Arch has side legs, United by their ends with the spray and made with the possibility of deformation of the spiral to ensure rotation of the arch [EN 2248816 C2, 2005.03.27].

Usually the wound surface is treated with a distance from her 30 see, However, the use of aerosol cans is not without drawbacks as well:

- the irrationality of use because of the excessive loss of substance;

- applying pressure finely crushed particles of drug substances, aerosols, are dissolved leads to Espinosa it from getting into the respiratory tract, eyes, skin and mucous medical staff that is fraught with the danger of allergic reactions;

- the impossibility of processing the scalp, face;

frequent failure of the device (the decrease of pressure, jamming heads, etc.);

To eliminate the described disadvantages of the prototype of the invention, a more economical consumption of the adhesive composition, the expansion of its application to various areas of the body, a new device for the application of pharmacological agents. The device contains a set magkabalikan rollers of various shapes and sizes, with the possibility of their movable mounting on the handle.

Figure 1 is a schematic diagram (option # 1): shows a General view of the device Assembly; figure 2 - the working part with lock; figure 3 is a cylindrical roller with a missing axis; figure 4 - roller spherical; figure 5 is a section a - a in figure 4; figure 6 is a cross-section B-B figure 3; figure 7 - ways-axis; Fig - section b-b In Fig.7(b); figure 9 (option 2) - whataboutery the latch roller; figure 10 is a roller with two protruding ends of the axis; figure 11 diagram whattobringa springy grip - latch roller; Fig - tightly closed Bank immersed rollers.

Device applicator (option 1) contains the handle 1, at the end of the subtle working part - terminal 2 movably mounted on the axis 3 magkabalikan the third roller platen 4, situated perpendicular to the rod 2. Directly from the end part of the rod 2 has a stationary lug-retainer 5 on which is mounted a roller 4, which rotation is possible due to the presence of the hard axis 3, missed exactly in the center longitudinally through the entire thickness of the platen 4. The rollers 4 are manufactured in different shapes: cylindrical (figure 3), spherical (figure 4 and 5), sizes and varied topography of the outer surface (6) - smooth "and"ribbed "b". Axis 3 (7) can be performed (options) solid (a), hollow (cylindrical) tube (b) with lateral through-hole (6) (serve for the introduction of adhesive compositions of the solutions), and solid (pigv) upromise conical shoulder 7, a warning retrograde exit thickness of the platen 4. Axis 3 can serve as an injection needle, produced by domestic industry. One end of the axis 3 is made in the form of a hollow conical socket 8 (7)used for mounting on the ledge 5 of the rod 2. Pets manufacturing of cylindrical rollers 4 integral with the axis 3 with putting on these porous soft elastic sleeve (not shown).

A second embodiment of the device applicator is fork spring, the latch plate (Fig.9) - heatproof coming from the front-end part of the working part of the rod 2. When the shaft 4, having a fluent speaker is surrounding the ends 10 of the axis 3, attached to the spring ends of the tongs 9.

Pre-assembled rolls of the missing axes are immersed in a glass vessel - Bix 12 (sterilized). Sterilization is carried out in an autoclave, the drums 45 minutes, the Composition is sterilized separately under the same conditions.

Before use, Bix 12 open, the tool out roller 4 (Fig 1), grasping him by the speaker socket 8 of the enlarged hollow end of the axle 3, and is placed on the ledge of the latch 5 (pre-sterilized one of the traditional ways) handle 2. By prokachivanija (application, not traction!) the roller 4 on the wound surface with moderate pressure to produce a uniform application of the adhesive composition. After 7-8 seconds of exposure cause the 2nd, 3rd and 4th layers. Additionally, the bandage is not applied. The patient after the operation is allowed to move. In uncomplicated wound healing sutures are removed in conventional terms with simultaneous removal of the easily peelable adhesive film.

Experimental (30) and clinical (70) observations showed that presents us lekarstvennye adhesive compositions and devices, applicators for application to fabrics offer significant advantages. When using them are provided:

technical simplicity and short duration of the procedure, which assumes special importance in outpatient conditions hee is Urga;

- reliability of the formed thin, lightweight film with high adhesive power.

- unhindered opportunity for practical application in all areas of the body of the patient;

- creating a strong contact the edges of the wound, its physiological dormancy are the necessary basic conditions functional treatment;

- a lightweight visual monitoring of healing;

significant efficiency due to the exclusion of expensive fabric bandages;

- regenerative activity of the composition, which has been proved by research.

Table 1
The results of the use of pharmaceutical compositions in the treatment of wounds depending on the clinical syndrome
Clinical syndromeMedicinal composition (variants of the claimed compositions)The adequacy of healing, %
ControlOptions
12345
Usl is UPE clean wound 3879089
"Exudation": necrosis57990
Infection18189
Fibrin57592
Granulati27495
Epithelialization380 89

Healing was considered adequate if the 8-day treatment was not observed complications, wound epithelials or has been a clear tendency of a favorable course of the wound process.

The control is carried out with the use of the prototype.

1. Pharmaceutical composition based medicines and glue BF-6, characterized in that its composition as an active component contains ingredients in following their ratio, wt.%:

hydrochloride Ximena8,0-10,0
dimexide28,0-30,0
dioxidine0,8-1,0
lidocaine hydrochloride9,0-10,0
glue BF-6rest

2. Pharmaceutical composition based medicines and glue BF-6, characterized in that its composition as an active component contains ingredients in following their ratio, wt.%:

td align="right"> 8,0-10,0
ksimedon
dimexide18,0-20,0
dioxidine0,8-1,0
lidocaine hydrochloride9,0-10,0
glue BF-6rest

3. Pharmaceutical composition based medicines and glue BF-6, characterized in that its composition as an active component contains ingredients in following their ratio, wt.%:

ksimedon6,0-6,5
brilliant green1,8-2,0
lidocaine hydrochloride9,0-10,0
glue BF-6rest

4. Pharmaceutical composition based medicines and glue BF-6, characterized in that its composition as an active component contains ingredients in following their ratio, wt.%:

ksimedon6,0-6,5
methylene blue 1,8-2,0
lidocaine hydrochloride9,0-10,0
glue BF-6rest

5. Pharmaceutical composition based medicines and glue BF-6, characterized in that its composition as an active component contains ingredients in following their ratio, wt.%:

hydrochloride Ximena8,0-10,0
potassium permanganate0,2-0,4
lidocaine hydrochloride9,0-10,0
glue BF-6rest



 

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5 cl, 8 dwg, 4 tbl, 11 ex

FIELD: medicine.

SUBSTANCE: method of obtaining wound bandage material is claimed. Method involves obtaining protein polymer by protein reaction with polyfunctional spacer or its activated derivative. Preferred polyfunctional spacer is polycarboxylic acid, especially dicarboxylic acid. Protein polymers obtained with such spacers can be applied in a wide range of therapeutic purposes, including wound bandage materials, therapeutic agent delivery to organism, and bioadhesive and sealing substances.

EFFECT: obtaining material taking exact shape of wound filling wound hollow completely without irritation of exposable tissues.

27 cl, 2 dwg, 13 tbl, 12 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine and claims plaster for local application, containing capsaicin or its analogue, method of its manufacturing, and application. Invention concerns plaster for local application, including substrate layer impermeable for therapeutic compound, self-gluing matrix based on polysiloxanes and containing capsaicin or therapeutic compound similar to capsaicin, and protection film removed before application; where matrix includes microreservoirs for fluid based on amphiphilic solvent in which therapeutic compound is placed in completely dissolved form, and concentration of therapeutic compound in microreservoir drops is lower than saturation concentration. Invention claims method of plaster production and application in neuropathological pain mitigation.

EFFECT: system stability required for high grade of active component deliberation.

15 cl, 4 tbl, 3 dwg, 5 ex

FIELD: medicine.

SUBSTANCE: invention concerns device for dosage of media applied on skin, particularly medicines and cosmetics. Particularly, invention concerns device in the form of lath (1) with indexed scale allowing for precise measurement of medicine applied onto skin depending on the surface of application.

EFFECT: precise measurement of medicine applied onto skin depending on the surface of application.

13 cl, 1 tbl, 4 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: transdermal therapeutic system (TTS) contains at least one pharmacological biologically active substance heated to temperature exceeding that of skin, thus increasing penetrating speed of biologically active substance, including at least one reverse layer impermeable to biologically active substances at least one layer containing biologically active substance, and removable protective layer. The layer containing biologically active substance mainly consists of polysiloxane with partially dissolved biologically active substance.

EFFECT: intensified system-invoked release of biologically active substance.

13 cl, 2 ex, 1 dwg

FIELD: medicine.

SUBSTANCE: according to invention, agent includes silicon composition of high laying viscosity becoming firm when applied through cross-link to form skin-favourable elastomer adhesive to skin. Invention also refers to method of agent application.

EFFECT: provision of protection of circumwound cutaneous covering.

15 cl, 4 dwg

FIELD: medicine.

SUBSTANCE: suitable for transdermal introduction of rotigotine [(-)-5,6,7,8-tetrahydro-6[propyl[2(2-thienyl)ethyl]amino]-1naphthol] in an organism, the polymeric matrix contains polymer forming it which is supersaturated with rotigotine in the form of the free base, thus not dissolved in a polymer forming a matrix the part of rotigotine is dispersed in it in the form of amorphous particles with average diameter of 30 microns maximum, and hydrotropic solubilisers, inhibitors of crystallisation and dispersants are absent in the matrix. The device of the flat form for transdermal introduction of rotigotine in an organism, containing specified above a rotigotine supersaturated polymeric matrix is described also, it is preferable on a silicon basis, and an impenetrable for rotigotine back layer.

EFFECT: matrix allows to provide therapeutically comprehensible rate of penetration of rotigotine from it through a skin.

14 cl, 7 dwg, 5 ex

FIELD: medicine; surgery.

SUBSTANCE: under intubation narcosis trocar laparocentesis is carried out in four points. Using endoscopic chamber of operation zone is visualised. Polytetrafluoroethylene film 0.5-1.0 mm thick sized by covered liver surface is prepared. Preliminary within 3 days film is kept in concentrated silver solution and Licopid dissolved in 0.9% sodium chloride solution. This film is envelope-like folded, seized with forceps and inserted to abdominal cavity through the most convenient trocar point. Using manipulator it is spread over all diaphragmatic liver surfaces. Film is lined in four points alongside liver parenchyma edges.

EFFECT: lower operative injury and intoxication; complex immunomodulating, antibacterial, antiviral, antitumor and antiinflammatory activity directly in pathology zone.

2 ex

FIELD: medicine.

SUBSTANCE: there is a description of medical plaster, containing active substance. It consists of one- or two-layered matrix, as well as of connected with the matrix protective layer. At least one of the matrix layers contains the active substance, the characteristic feature of which consists in the fact, that it becomes transparent or at least semi-transparent, that plaster, applied to the skin of the first user, provides L1 luminosity intensityon the skin under the plaster not less than 50% and not more than 200% of L2 luminosity intensity, that corresponds to luminosity intensity of the user skin integuent zone, surrounding the plaster. The above is correct as for skin integuent of the second or any other user on condition that L2 of all mentioned users fluctuates from 5° to 100°, especially from 20° to 90°. The plaster produces feeling of notelessness, especially during process of application.

EFFECT: production of notelessness feeling in process of plaster application.

11 cl, 4 tbl

FIELD: medicine.

SUBSTANCE: described is device for transcutaneous introduction of nicotine, which ensures basic as well as additional introduction of nicotine activated by user. Invention also describes device for combined basic and additional transcutaneous delivery of nicotine activated by user ensuring different rates of nicotine delivery to individual.

EFFECT: increase in means efficiency.

13 cl, 6 dwg, 3 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, oncology and to be used for neoadjuvant chemoradiotherapy in the patients suffering from thoracic oesophagus cancer. Said therapy is ensured by introduction of cisplatin and leucovorin, and continuous intravenous infusions of fluorouracil dosed 300 mg/m2. Cisplatin solution is introduced intravenously drop-by-drop and dosed 6 mg/m2 daily once a day within 1 hour. Leucovorin is injected intravenously jet-like and dosed 30 mg/m2. Radiotherapy involves daily fractions 3 Gy to total basic dose 30 Gy. The course dose of fluorouracil is 3600 mg/m2, of cisplatin is 72 mg/m2, of leucovorin 360 mg/m2. Chemotherapy and radiotherapy are to be started the same day.

EFFECT: disclosed method allows for considerably reduced toxicity of treatment to be continuous, treatment of the patients originally of bad performance status, for doubly reduced time of neoadjuvant treatment with maintaining high clinical effectiveness.

2 ex

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