Method of bracing of medical products on carrier

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely to reconstructive surgery, traumatology-orthopedy, maxillofacial surgery, stomatology and can be applied at osteo-plastic operations. For delivery of medical products immediately in a zone of defect and their prolonged influence in the centre of a lesion medicinal preparations are dissolved in a normal saline solution in a dose providing local effect, collagen-containing component is added to a solution in the ratio 9-20 g: 100 ml of a solution also admix with the carrier from dispersed allotransplants in the ratio of 1:1-3.

EFFECT: method allows lowering a dose necessary for reception of medical effect in 10 times, and also allows accelerating reparative processes in a defect zone.

3 dwg

 

The invention relates to medicine, namely to reconstructive surgery, traumatology, orthopedics, maxillofacial surgery, dentistry, and can be applied to bone-plastic surgery for drug delivery in the area of the defect and prolonged exposure in the lesion.

The introduction of drugs directly into the area of extensive bone defect by injection does not ensure their long-term presence in the area of bone damage and prolonged stimulation of osteogenesis (Solheim. Osteoinduction by demineralized bone // J. Int. Orthop. (SICOT). 1998. No. 22. P.335-342). Therefore, medication should be delivered to the area of the defect with the help of various implants, which are able to adsorb them, and then to allocate a period of time sufficient to complete the regeneration.

There is a method of saturation grafts drugs according to the method Ivema (Sumida IV, Skrypnyk P.A., Krivenko V.M. Way saturation bone grafts medication // Orthopedist., traumatol. - 1979. No. 11. - P.65-66). The grafts injected by three vacuum necessary in the solution for 45 minutes at a pressure of 1 kg/cm2. The material, full of drugs in a similar way, has certain disadvantages: drugs fill the pores and gaverova Kahn the crystals, and in the body, they are quickly eliminated from the graft and lose their specified properties.

Closest to the claimed method is a Method of fixation of antibiotics in porous implants", the application for invention No. 2005122113, priority dated 12.07.2005 (Bazarov, A., Osintsev V.M., Beketov B.N.). The method involves filling the micropores of the implant with an antibiotic solution in the liquid gel by immersing the implant from nickelide titanium in a sterile liquid gel3/4the height of the implant. Partial immersion leads to the presence of free antibacterial drugs zones component3/4the height of the implant. The implant is maintained in a liquid gel to form a tight gel that occurs at room temperature (18-20°). During implantation in the human body, the body temperature which in norm equal 36,6°With dense gel turns into a solution and flows out into the surrounding tissue. This leads to short-term selection of antibiotics during the first days after surgery. Furthermore, the method is intended only for the fixation of antibiotics in porous implant from nickelide titanium.

The objective of the invention is to devise a method of fixation of medicines on the media for their local and prolonged isolation.

The technical result of the use of developed the data method is the delivery of drugs directly into the affected area to provide local and prolonged exposure; a significant reduction (10-fold) dose required for therapeutic effect; the possibility of recording media of different groups of drugs depending on the desired therapeutic effect; acceleration of reparative processes in the area of the defect.

The problem is solved due to the fact that the drugs are dissolved in 0.9% saline solution at a dose that provides local effect, add to the resulting solution containing collagen component in the ratio of 9 to 20 g per 100 ml and mix it with a carrier of the dispersed allografts in the ratio of 1:1-3.

The technical result is achieved due to the fact that as the carrier are dispersed allografts, which due to their structure, are able to adsorb drugs from collagen containing component, and then select them for a long period of time. Because saline salt composition and osmotic pressure close to the plasma, it is optimally suited for the dissolution of various drugs. Collagen component as a natural intercellular protein, and the media - dispersed allograft, contribute to the processes of reparative regeneration of bone tissue.

The method is a trail which accordingly. In physiological solution (0.9% NaCl) are necessary drugs (antibacterial, vascular, money, influence metabolism and other), at a dose 10 times less therapeutic. Then added collagen component in the ratio of 9 to 20 g per 100 ml of solution to obtain a liquid gel. The gel is mixed containing buried by allografts in the ratio of 1:1-3.

The duration of excretion of drugs from bingosites were studied in the process of bacteriological experiment fixation of antibacterial drugs on bingosites in vitro. It was established that the dose of antibiotics 0,02% (10 times less than therapeutic) provides local suppression of growth of microorganisms within 21 days under a load of 2.5×107CFU/ml (Fig.1-3).

The figure 1 shows the zone of growth inhibition of laboratory strains of microorganisms on agar Mueller-Hinton after 1 day: (a) Escherichia coli (E.coli) - 34 mm; b) Pseudomonas aeruginosa - 40 mm; C) Staphylococcus aureus - 32 mm

The figure 2 shows the zone of growth inhibition of laboratory strains of microorganisms on agar Mueller-Hinton after 14 days: (a) Escherichia coli - 27 mm; b) Pseudomonas aeruginosa - 32 mm; C) Staphylococcus aureus - 28 mm

The figure 3 shows the zone of growth inhibition of laboratory strains of microorganisms on agar Mueller-Hinton after 21 days: (a) Escherichia coli - 21 mm; b) Pseudomonas aerginosa - 25 mm; C) Staphylococcus aureus - 22 mm

By selecting different groups of drugs can prevent suppurative complications, to stimulate angiogenesis, chondro - and osteogenesis in the damaged tissues, to increase the intensity of metabolic processes, which contributes to the optimization of conditions for reparative regeneration of bone tissue.

The method of fixation of drugs on the carrier by dissolving the drugs in liquid gel, characterized in that the dissolved drugs in physiological solution at a dose that provides local effect added to a solution containing collagen component in the ratio of 9 to 20 g per 100 ml of solution and mixed with a carrier of the dispersed allografts in the ratio of 1:1-3.



 

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