Compositions and medicinal forms on basis of gastrinum, application and reception methods

FIELD: medicine.

SUBSTANCE: invention concerns area of medicine and concerns compositions and medicinal forms on the basis of Gastrinum, application and reception methods. The essence of the invention includes the bond of Gastrinum representing conjugates of fragments of amino-acid sequence of Gastrinum, possessing functional ability to contact Gastrinum/SSK receptor, with various carriers, including application amino-acid spacers, and application of bifunctional sewing agents, and also a method of treatment by the compositions including bond of Gastrinum, sick of diabetes.

EFFECT: advantage of the invention consists in action prolongation.

7 cl, 8 ex, 3 tbl, 2 dwg

 

The text descriptions are given in facsimile form.

1. Connection gastrin, including amino acid sequence containing the amino-end Z-Ym-X-Tyr-Gly-Trp-Leu-Asp-Phe-NH2,

where Z is a human serum albumin or polyethylene glycol;

Y means (Gly-Ala);

m is 0 or 5;

X is Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala, and the cysteine residue at amino ends of the Y, when m is 5, or the amino ends of X, when m is 0,

provided that the connection gastrin binds to the receptor gastrin/Sscv.

2. Connection gastrin according to claim 1, in which Z stands for human serum albumin.

3. Connection gastrin according to claim 1, where m is equal to 5.

4. Connection gastrin according to claim 1, where m is 0.

5. A pharmaceutical composition comprising a compound of gastrin p is any one of the preceding paragraphs and pharmaceutically acceptable carriers or excipients.

6. A method of treating diabetes in a patient, which consists in the introduction of this patient the pharmaceutical composition according to claim 5.

7. The way to maintain over a long period of time a higher level of gastrin in serum compared to the level of a peptide having the amino acid sequence of gastrin in serum, introducing a pharmaceutical composition according to claim 5.



 

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49 cl, 51 dwg, 8 tbl, 58 ex

FIELD: chemistry.

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8 cl, 5 ex

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16 cl, 38 ex

Diabetes treatment // 2339398

FIELD: medicine, pharmacology.

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17 cl, 2 tbl, 3 ex

FIELD: medicine; cardiology.

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12 cl, 2 tbl, 2 ex

FIELD: medicine; pharmacology.

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17 cl, 12 tbl, 425 ex

FIELD: medicine.

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4 ex

FIELD: medicine, endocrinology, pharmacy.

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1 ex, 2 dwg

FIELD: medicine, cardiology, endocrinology, hematology.

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4 ex, 1 tbl

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14 tbl

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16 cl, 24 dwg

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70 cl, 17 dwg

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2 cl, 1 tbl

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20 cl, 7 tbl, 22 dwg, 10 ex

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31 cl, 6 dwg

FIELD: medicine, virology, immunology, molecular biology.

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EFFECT: valuable biological and medicinal properties of matrices.

28 cl, 7 dwg, 20 ex

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EFFECT: valuable biological properties of conjugates.

27 cl, 2 dwg, 6 tbl, 6 ex

FIELD: chemical and pharmaceutical industry.

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13 cl, 8 ex, 4 tbl, 2 dwg

FIELD: medicine.

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EFFECT: improved and valuable properties of cytokines.

21 cl, 3 tbl, 11 ex

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