Method of producing gel based on water extraction from unossified antlers

FIELD: beiotechnology.

SUBSTANCE: invention concerns production of items with expressed bioactivity and can be applied as healing and preventive medicine in medical cosmetology, balneology, medicine and veterinary. Method involves extraction of bioactive substances from unossified antlers at 40°C or lower temperature, conservation and gelatinisation agent addition to obtain aqueous solution of conservation agents represented by methylparaben and propylparaben. Extraction of bioactive substances is performed by conservation agent extraction to the solution by ultrasonic method in cavitation mode at weight ration of unossified antlers to aqueous solution of 1:1-10 for time period sufficient to obtain required extract concentration. Carbopol is used as gelatinisation agent and mixed with distilled water preliminarily and aged till imbibition, then neutralising agent is added in amount sufficient to form gel mass, further neutralised by adding citric acid solution to 6-7.5, and aqueous solution of unossified antlers and 1-30 wt % of water retentive component are added to obtained gel mass in portions with stirring.

EFFECT: obtaining high-quality gel based on aqueous solution of unossified antlers by ultrasonic extraction of bioactive substances.

2 cl, 5 ex, 2 tbl

 

The invention relates to the manufacture of products with pronounced biological activity and can be used as a therapeutic and preventive tool in medical cosmetology, balneology, medicine and veterinary medicine.

It is known that in the Pharmacopoeia of Russia antler extract indicated in the section "tonic medicines and marketed drug "Pantocrine", which is based alcoholic extract (see Drugs: properties, application, contraindications: a Handbook / edited Maglev. - M.: Russian book, 1993, s-325).

The disadvantage of this drug is the lack of some important elements of the composition of antlers, which are not soluble in alcohol processing of raw materials.

Known drug "Pentagram" and the method for its substance. "Pentagram" antler contains flour, powdered sugar and vanilla in the following ratio, wt.%: antler flour 45-55; sugar 49,94-49,96; vanilla 0,04-0,06. A method of obtaining a substance (Dag flour) for the medicinal product "Pentagram" consists in grinding the dry antlers from the skin of deer, deer or spotted deer to particles of 5-10 mm, and then re-grinding to particles less than 0.1 mm (see application for invention No. 92003697, IPC AC 35/32).

However, the method of obtaining a substance (antler MUK is), used for the manufacture of a medicinal product "Pentagram"includes re-grinding of dry antlers. In addition, for conservation of horns used method of drying that reduces the biological activity of antlers flour.

Known dosage form of pantogematogen on a gel base for topical application, which comprises, by wt.%: pantogematogen in the form of a 3%aqueous-alcohol solution with a content of 8-14% ethanol 5-35, polymeric gel-forming composition based on reconsidera polymer of acrylic acid and/or polyvinylpyrrolidone 0.5 to 15 and water - other (see RF patent №2200564, IPC AC 35/14).

However, the biologically active component of the pharmaceutical form of pantogematogen on helium based pantogematogen dry, obtained from the blood of deer, the deer or spotted deer by vacuum drying and dosage form is administered in the form of an aqueous-alcohol solution containing 8-14% ethyl alcohol. Drying of raw materials, and the use of ethyl alcohol impair the useful properties of pantogematogen.

Closest to the claimed method is a method of preparing the gel from antlers and waste their pharmaceutical processing, in which crushed antlers or use shredded waste their pharmaceutical processing, mixed with artificial jeludochnogo in the ratio of 1:10, placed in a thermostat at 37-40°for three days, mix 1 time per day 2-3 min, filtered, the filtrate is sterilized by boiling, canning resorcinol add methylcellulose in a ratio of 3 g per 100 ml and stirred until a homogeneous gel consistency (see RF patent №2248802, IPC AC 35/32).

The disadvantage of this method are adverse effects on biologically active substances antlers hydrochloric acid (the main component of the artificial gastric juice), heating, boiling, and length and a multi-stage process of preparation of the gel.

The task of the invention to provide a gel of high quality based on an aqueous extract of the antler at the expense of ultrasonic extraction of biologically active substances.

The technical result is to preserve and enhance the biological activity of the obtained gel-based aqueous extract of antlers by eliminating the influence of high temperatures and processing of chemical agents.

The problem is solved in that in the method of manufacturing gel antler, including the extraction of biologically active substances from antlers at a temperature not exceeding 40°With the introduction of preservatives and gelling, according to the invention receives an aqueous solution of preservatives, which are used Matilda the Aben in an amount of 0.01-0.2 wt.% and propylparaben in the amount of 0.002 to 0.01 wt.%, extraction of biologically active substances carry out the extraction in the resulting solution preservatives ultrasonic method in the cavitation mode when the ratio of the mass of antlers by weight aqueous solution of 1:1-10 during the time required to obtain the desired concentration of the extract as a gelling choose the carbopol in the amount of 0.5-2 wt.%, pre-mixed with distilled water, can withstand before swelling, add a neutralizing agent in an amount to provide the formation of a gel-like mass, which is neutralized by the introduction of citric acid solution to pH 6-7,5, and the obtained gel-like mass in portions with stirring an aqueous extract of the antlers and 1-30 wt.% the hydrophilic component.

As the hydrophilic component can be used glycerol as a neutralizing agent is sodium hydroxide.

It was established experimentally that the content of gelling less than 0.5 wt.% does not provide a sufficient viscosity of the composition that does not allow you to attach it to the body. When the content of gelling more than 2 wt.% experiencing technological difficulties, and it is difficult mixing and obtaining a homogeneous mass of gel and packing of the finished product. Beyond the content of the neutralizing agent NaOH also decided the Lena content of the gel, because lye is involved in the neutralization of acid groups (-COOH) of carbopol. The content of citric acid is determined by the amount necessary to regulate the pH of the gel to the value of 6-7,5. The limits of the content of the humectant (glycerol) due to the following reasons. When the content is less than 1 wt.% not saved lubricating and moisturizing effect due to the loss of the ability of the gel to retain moisture. When the content is more than 30 wt.% may be disrupted natural water-salt balance of skin microflora. The lower limit of the content of the mixture of preservatives (MP + PP) sufficient to prevent the emergence and reproduction of microorganisms during the shelf life (at least 10 months). The upper limit is determined by the quantity that has not yet has a painful impact on the human body. In addition, we note that obtaining an extract of an ultrasonic method facilitates decontamination gel.

The method consists in the following. First of ultrasonic extraction in the cavitation mode are preparing an aqueous extract of antlers, containing biologically active substances and containing preservatives.

Prepare polymeric gel-forming composition consisting of a gel and a neutralizing reagent. Gelling is chosen from the group of polymers, family Carbopol (international classification - It is Romer, complies with British Pharmacopoeia BP 516-93). The neutralizing reagent is chosen from the group of organic and inorganic bases. The organic base is triethanolamine, inorganic bases are selected from the group of hydroxides of alkali metals, aqueous solution of ammonia. The pH value is controlled by the introduction of citric acid. The gel is mixed with distilled water, mix, stand alone for 30 min, sufficient to swell, then add the neutralizing agent in an amount to provide the formation of a gel-like mass was incubated for 30 min, neutralized with citric acid solution to pH 6-7,5 and portions under stirring administered aqueous extract of antlers that contain preservatives, such as methylparaben (MP) and propylparaben (PP). In the resulting system portions impose water-retaining agent (glycerin, propylene glycol), mix and leave to rest for one day. Then, the resulting gel is again mixed and Packed in sterile containers (tubes). The composition of the primary components of the gel may contain by weight, % carbopol - 0.5-2; sodium hydroxide - 0.5-2; citric acid to pH 6-7,5; glycerol - 1-30; preservatives MP - 0.01 to 0.2 and PP - 0,002-0,01.

In the composition of the gel as a result of interaction of components of citric acid and sodium hydroxide will include citrate NAT the Oia, used in the pharmaceutical industry as a component of many drugs, in particular as an anticoagulant (Chemical encyclopedia: 5 t: 2: Duff - Copper X 46 / editorial Board; Knunyants I. (editor-in-chief;and others - M.: Owls. day., 1990. - s-1180).

The following examples illustrate the present invention.

Conditions for obtaining a gel based on an aqueous extract of the antler and composition are presented in tables 1 and 2.

Example 1.

Initially mechanically remove wool with canned (ferry) deer antlers, deer or spotted deer. Spend kvartsevanie and cut the antlers in the transverse direction of the large proportion of size 2-5 see Put them in an aqueous solution of preservatives (MP - 0.01 wt.% and PP 0.002 wt.%) when the ratio of the mass of antlers by weight solution of 1:10. This was followed by ultrasonic extraction in the cavitation mode at a temperature of 40°C for 25 minutes After completion of the extraction process antler fraction and an aqueous extract of the share, pouring the last in an airtight container. Conditions for obtaining and characterization of aqueous extract of antlers shown in table 1.

For the preparation of gel use simple equipment, equipped with a mixer reactor with a stirrer. In the mixer load components of the gel according to the recipe (wt.%): the carbopol ULTREZ 10 (2%), distilled water, NaOH solution (2%), p is remediat, incubated for 30 min, titrated with a solution of citric acid to a pH of≅6-7 and administered aqueous extract of antlers that contain preservatives. As the mixture is injected glycerol in the amount of 2 wt.%. The system is stirred for 10 min and measure the pH. The resulting homogeneous gel Packed in containers. Characteristics of the gel and the composition is shown in table 2.

Example 2.

Stage of the method of obtaining an aqueous extract from antlers similar to example 1. Used frozen antlers. The ratio of the mass of antlers to the mass of water is 1:5. Ultrasonic extraction is carried out in an aqueous solution of preservatives (MP=0,19 wt.% and CPP=0.01 wt.%) at a temperature of 18°C for 15 minutes (table 1). For preparation of a gel based on the aqueous extract of gelling carbopol mixed with distilled water and leave to swell for 30 minutes Then add the NaOH solution in a quantity sufficient to gel formation, the system can withstand 30 min, titrated with a solution of citric acid to a pH of≅6 and portions under stirring injected extract, glycerin (9 wt%), mix and leave to ripen for one day. Then the gel is stirred and homogeneous mass is Packed in a container. Characteristics and composition of the gel are given in table 2.

Example 3.

All the stage of an aqueous extract antler similar when the ERU 2, in addition to the time of extraction (table 1). All operations of receipt of the gel and the extract is also analogous to example 2. Physico-chemical characteristics and composition of the gel are shown in table 2.

Example 4.

In the main stage of obtaining an aqueous extract from antlers similar to example 2 except that the time of extraction. In addition, for disinfection of the finished extract is filtered through filters with a pore size (dthen)=0.8 and 0.45 µm (table 1). The gel from this extract prepared analogously to example 2. Characteristics and composition of the gel are given in table 2.

Example 5. Differs from example 3, the temperature of extraction.

Gel-based aqueous extract antler effectively regenerate tissue damaged by trauma and burns, improves elasticity and nourishment of the skin, reduces the effects of dryness, inflammation and other adverse effects to the environment due to the presence of the unique composition of biologically active substances, including macro - and micronutrients, antioxidants, vitamins and other beneficial ingredients. The resulting gel contains no corrosive environments associated with other drugs of antlers. The method allows to obtain a complex multi-component composition which includes proteins, amino acids, hormones, lipids, minerals, complex compounds, which have expressed the OI biological activity.

Industrial applicability. We offer gel can be prepared as in large cosmetic factories, enterprises, and in plants of small firms with the appropriate equipment.

Table 1

Conditions for obtaining and characterization of aqueous extract of antlers.
Name of indicator and unit of measureExamples
12345
Appearance and colorliquid red of various shades
Method of canning antlersthe steam processingfreeze
The ratio of the mass of antlers by weight aqueous solution of preservatives1:101:51:51:4,51:4,6
The temperature of extraction, T°4018181735
The time of extraction, min2515203020
Filteringthrough biological filters with dthen=0.8 and 0.45 µm
The content of preservatives (wt.%):
the methylparaben0,010,190,190,20,19
of propyl paraben0,0020,010,010,0030,01
The solids content, wt.%0,330,811,11,11D
The total protein content, wt.%0,110,670,820,941,12
The hemoglobin content, wt.%of 0.0810,360,440,500,8

Table 2

Physico-chemical characteristics and composition of the gel.
Name of indicator and unit of measureNorm GOST R-2005Examples
12 345
AppearanceA homogeneous mass, which does not contain impuritiesA homogeneous mass, which does not contain impurities
ColorTypical color of this creamlight browndark red
SmellPeculiar smell of this gelPeculiar smell of this gel
Mass fraction of water and volatile matter, wt.%5,0-98,094,888,587,590,692,4
Colloidal stabilityStableStable
ThermostabilityStableStable
Fraction of total mass of heavy metals, % (mg/kg), no more than0,0020 (20,0)Complies with GOST R-2005
Microbiological indicatorsComplies with the norms SanPiN 1.2.681-97Complies with the norms SanPiN 1.2.681-97
The content of water extract, wt.%7072726470
The content of the gel (carbopol), wt.%1,50,91,11,31,2
The content of citrate1,50,91,01,31,3
Glycerin content, wt.%29,09,46,04
The content of methylparaben, wt.%0,0070,140,140,130,14
The content of propyl paraben, wt.%0,00140,0070,0070,0020,007
PH5,0-9,06,26,06,8 6,47,0

1. A method of manufacturing gel antler for outdoor applications, including the extraction of biologically active substances from antlers at a temperature not exceeding 40°With the introduction of preservatives and gelling, wherein receiving an aqueous solution of preservatives, which are used methylparaben in an amount of 0.01-0.2 wt.% and propylparaben in the amount of 0.002 to 0.01 wt.%, extraction of biologically active substances carry out the extraction in the resulting solution preservatives ultrasonic method in the cavitation mode when the ratio of the mass of antlers by weight aqueous solution of 1:1-10 during the time required to obtain the desired concentration of the extract as a gelling choose the carbopol in the amount of 0.5-2 wt.%, pre-mixed with distilled water, can withstand before swelling, add a neutralizing agent in an amount to provide the formation of a gel-like mass, which is neutralized by the introduction of citric acid solution to a value of 6-7,5, and the obtained gel-like mass in portions with stirring an aqueous extract of the antlers and 1-30 wt.% the hydrophilic component.

2. The method according to claim 1, characterized in that the hydrophilic component is chosen glycerin, as a neutralizing agent - hydrox the d sodium.



 

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