Meningococcal vaccines for administration via mucosa

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns vaccines, particularly vaccines for meningococcal infections and diseases. Invention claims immunogenic composition for transport via mucosa, including capsular saccharides of at least two of the following serological groups: A, C and W135 and Y N. Meningitidis, as well as trialkylated chitosan.

EFFECT: enhanced production of immune response to meningococci in mucosa, possible balance shift of Th1/Th2 type responses.

16 cl, 24 dwg

 

The text descriptions are given in facsimile form.

1. Immunogenic composition for delivery via the mucous membrane, containing capsular saccharides, at least two of the following serological groups A, C and W135 and Y of N.meningitidis, and also containing trialkylamines chitosan.

2. Immunogenic composition comprising (a) capsular charigny antigen serological groups With N.meningitidis and (b) trialkylamines chitosan adjuvant.

3. The composition according to claim 2, containing (C) one or more additional antigens and/or (d) one or more additional adjuvants.

4. The composition according to claim 1, where these capsular saccharides conjugated to a protein(s)carrier(s) and/or are oligosaccharides.

5. The composition according to claim 3, where these capsular Oriental is s represent oligosaccharides, conjugated with protein(s)carrier(s).

6. The composition according to claim 1 or 2, containing capsular saccharides from 2, 3 or 4 serological groups a, C, W135 and Y of N. meningitidis.

7. The composition according to claim 6, containing sugars serological groups a+C, A+W135, A+Y, C+W135, C+Y, W135+Y, A+C+W135, A+C+Y, C+W135+Y or A+C+W135+y

8. The composition according to claim 1 or 2, prepared and/or packaged for intranasal.

9. The composition of claim 8, prepared in the form of an intranasal spray or nose drops.

10. The composition according to claim 1, containing additionally methoxycarbonyl mutant thermo-labile toxin of E. coli.

11. The composition according to claim 1 or 2, where the specified trialkylamines chitosan is trimethylchitosan.

12. The composition of claim 10, where the specified methoxycarbonyl mutant thermo-labile toxin of E. coli has a substitution of serine to lysine at residue 63.

13. The way of generating an immune response in a patient, introducing a patient a composition according to any one of claim 1 or 2.

14. The use of capsular saccharides, at least two of the following serological groups a, C, W135 and Y of N. meningitidis, where these capsular saccharides conjugated to a protein(s)carrier(s) and/or are oligosaccharides, and trialkylamines chitosan for the production of a drug for delivery to the animal through the mucous to develop his immune response.

15. PR is the application of (1) the capsular saccharide, at least one of the serological groups a, C, W135 and Y of N.meningitidis, where specified capsular saccharide anywhereman with protein(s)carrier(s) and/or it is an oligosaccharide, and (2) trialkylamines chitosan for the production of a drug for delivery to the animal through the mucous to develop his immune response.

16. Use 14 or 15, where the specified drug is intended for intranasal delivery.



 

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27 cl, 2 dwg, 6 tbl, 6 ex

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13 cl, 8 ex, 4 tbl, 2 dwg

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21 cl, 3 tbl, 11 ex

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5 tbl, 2 ex

Neisseria antigens // 2347813

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11 cl, 2 tbl, 104 ex

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