Method of treatment of chronic obstructive pulmonary disease in form of dust bronchitis in coal industry workers

FIELD: medicine; physiotherapy.

SUBSTANCE: ultrasonic inhalations of 10 ml solution of 1% placenta hydrolyzate are applied at temperature of solution 35°C within 10 minutes. Procedure is applied in the morning on an empty stomach, or 40-60 minutes after eating. It is followed with scanning laser therapy with infra-red laser radiation from laser scanning physiotherapeutic stimulator LSPS-03.2IR. Output power at light guide end is 2 mWt, power flux density is 50 mWt/cm2. While exposure the patient is positioned lying on stomach, thus effecting paravertebral fields to the right and to the left at level D3-D9, within 3 minutes per each field. Then while the patient is positioned lying on back, liver region is exposure within 8 minutes. Course is 10 daily procedures.

EFFECT: normalised eliminative properties of epithelial barrier of a respiratory tract and local immunity of airway mucous membrane.

3 tbl, 2 ex

 

The invention relates to medicine, in particular to physiotherapy in the rehabilitation of patients with chronic obstructive pulmonary disease (COPD) in the form of dust bronchitis, in particular, when pneumoconiosis workers in the coal industry.

Medical rehabilitation pulmonary sick and disabled persons among the working in the coal industry are extremely complex. For working coal mining characterized by the development of intrakota. Antraks and other carbonize usually develop slowly, often observed phenomenon of bronchitis. The annual economic loss in connection with the payment of benefits for occupational diseases (occupational bronchitis, pneumoconiosis) exceed 1800 rubles per worker. A distinctive feature of this group of persons is a combination of somatic diseases and irreversible morphological changes in organs and tissues. Dust falling from the pulmonary alveoli into the lymph vessels and glands, causing reactive inflammation around the bronchi and then into the interstitial lung tissue. In the future, come fibrotic changes, develop bronchiectasis and emphysema. Of great importance not only dust in the lungs, but its delay in them. The better is the purification of the lungs from the dust by the mucociliary escalator, the less remains in organizme the less the risk of pneumoconiosis. The initial stage of development of any of pneumoconiosis is the formation of dust depot due to the fact that the amount of dust that stays in the lungs when breathing exceeds the number of dust particles that are removed from them. The average duration of the period from the beginning of the dust to the development of the disease is 10-15 years. These years are the most intensified in an underground working, the condition of the body which is still quite high adaptive reserves, and medical activities will help to maintain physiological output path of dust particles from the bronchial tree and to protect lung tissue from pathological changes (Leontiev EL, Khanin A.L. Complex treatment of patients dust lesions with the use of prolonged broncholytic Tiotropium bromide. - In the journal of Medicine in Kuzbass Restorative treatment of victims of industrial and occupational diseases for health stage. - special issue No. 5, 2006, p.72-74; Filimonov, S., Gorbatovsky AA, Stankevich N.G., Batarina NV, Fedoseeva, NV, Goryacheva O.V. estimation of the importance of some risk factors for the prevention of coronary heart disease in miners with dust lung pathologies. - In the journal of Medicine in Kuzbass "Restorative treatment affected the production and occupational diseases in sanata the s phase. - special issue No. 5, 2006, s-117). Although the nature of the current antraks refers to favorably flowing forms of pneumoconiosis, the urgency of the problem is obvious, and requires timely search techniques to prevent the development of pulmonary insufficiency on the background of the formation of pneumosclerosis.

Prolonged medication non-steroidal anti-inflammatory and antibacterial drugs, various anticholinergic this group of patients leading to functional disturbances of the liver and the formation in it of chronic metabolic disorders. In addition, although the pathogenetic validity and high efficiency of the methods, the results of treatment of patients with occupational pulmonary diseases suggests that a positive outcome is achieved in 50-60% of patients. To increase the effectiveness of treatment requires a comprehensive approach to this complex and socially significant problems and the search for new promising and relatively safe factors, which include physiotherapy methods. Rehabilitation treatment in this case is aimed at increasing functional reserves, compensation of disturbed functions of the epithelial barrier of the mucosa of the respiratory tract throughout, W the ranks prevention of respiratory diseases and their complications, the restoration of reduced labour functions and return capacity (Velichkovsky BT Molecular and cellular basis for environmental pulmonology. - W. Pulmonology - 2000. No. 2. - p.10-18).

Thus, the search for methods of rehabilitation of patients with diseases of the respiratory system to date has not lost relevance and requires new approaches to the development of medical technologies in this group of patients. Pathogenetically justified in recurrent and chronic diseases of the upper and lower respiratory tract method aerosol therapy (Sereda V.P. Ponomarenko G.N., Whistles A.S. Inhalation therapy of chronic obstructive pulmonary disease. - Saint-Petersburg. - 2004. - p.6-8). Medical practice has a number of drugs derived from natural raw materials, which retain all native properties. The ciliated epithelium lining the respiratory tract, makes about 900 oscillating movements per minute, "sweeping away" from the lungs huge number of particles that fall there. Under the influence of ions aerosols oscillatory movement of the ciliated epithelium of accelerated restored ciliary apparatus. In addition, once in the human respiratory organs, aerosol particles cause irritation of nerve endings in the lungs, partially penetrate through the walls of the pulmonary alveoli into the blood and is opline immunocompetent cells in nearby lymph nodes, thus, have an effect on the entire body. This explains therapeutic effect of aerosol ions biostimulating character in the professional pneumoconiosis (Orlov A.V., Gembicky I.E. Bronchial secret: education, excretion, changes under the influence of drugs. - Allergology. - 1999. No. 4. - p.37-42). Obviously the advantage of native aerosol mixtures that have expressed immunocorrective effect on cellular immunity of the mucous of the respiratory tract. However, if the inflammatory lesion in the bronchial tree, not just one impact on local mechanisms of nonspecific resistance. Need a better stimulating effect on the lesion and metabolism in General.

On clinical and experimental data laser therapy has unique capabilities. It extends microvessels and new forms, stimulates the oxidation-reduction processes, activates enzymes, changes in membrane potential. The irradiation of laser normalized rheological parameters of blood, increases the supply of oxygen to tissues, decreases ischemia in the tissues of the body, reduces cholesterol, triglycerides, sugar, inhibited the release of histamine and other mediators of inflammation from mast cells, oppressed synthesis prostagen the ins, a normalization of the immune system. At the same time, patients with chronic lung diseases are increasingly applied in physical therapy recovery rate without pharmaceutical drugs, as well as decreases the risk of developing medical complications (Kozlov V.I., Bolin VA, N. Samoilov, Markov I.I. fundamentals of laser physiotherapy and reflexology. - Samara-Kiev, 1993. - p.14; Gabay, S., Kremer I., Ben-Sira I., G. Erez, Retinal thermal response to copper vapor laser exposure, Laser Surg. Med. - 1998. - N 8: 418).

Known methods of physiotherapy treatment of patients with COPD in the form of dust bronchitis in the initial stages of pneumoconiosis, when the phenomenon of pneumosclerosis are absent or poorly expressed, methods, aerosol therapy and high-frequency factor: EP UHF-therapy to the chest area. High frequency therapy promotes the removal of deposited dust from lymph nodes (Intein, Ldendy and others. Clinical physiotherapy.- Republican.- "Health". - 1996. - c.596-597).

However, these methods are effective only in the initial stage of the disease are contraindications to the use in cases with concomitant diseases, the effect of the application is stored up to 2 months.

The closest in technical essence is a method of treating COPD in the form of dust bronchitis pneumoconiosis, intrakota) method fizi therapy, by exposure to ultrasound fields on chest (Alferov). The method is that the patient lying on the stomach first effect on the two paravertebral field from the level of T2-T8,then sitting on the two side of the field and two subclavian apparatus of UST-101, the diameter of the radiating head 4 see ultrasound Intensity of 0.2-0.4 W/cm2. The exposure time for 2 minutes on the field. Procedures carried out daily, the rate of 12-15 procedures. During exacerbation of inflammation in the lungs is conducted additionally inhalation of enzyme (trypsin). This method causes a positive influence on the processes in the lung tissue, autonomic regulation, as well as favourable effects on the immune and reparative activity due to cavitation ("cellular massage") component of therapeutic mechanism of action of ultrasound. In tissues that are rich in water (blood, lymph, muscle tissue), amplification of diffusive processes, the rate of biochemical reactions that cause temperature gradients. Aerosol trypsin can significantly reduce sputum viscosity and efficiently evacuate her from the bronchial tree. (Mgorobets, Genpharma. Handbook on electromagnetotherapy. - Hippocrates. - 2002. - s-185).

However, this method has drawbacks:

- is only effective in 20% of patients with disease duration more than 5 years;

- anti-relapse effect of short (3-4 weeks);

- remain vegetative disturbances without stable positive dynamics immediately after the end of treatment;

therapeutic effect is achieved only when respiratory failure 0-1 severity.

The OBJECTIVE of the INVENTION

Increasing the efficiency of treatment of COPD in the form of dust bronchitis in workers of the coal industry with varying degrees of severity of the pathological process, due to the normalization of the functional and elimination properties of the epithelial barrier of the respiratory tract, as well as achieve normalization of local immunity of the mucous membrane of the respiratory tract.

This object is achieved in that a method of treating chronic obstructive pulmonary disease in the form of dust bronchitis in workers of the coal industry includes inhalation and exposure to physiotherapy factor. Conduct ultrasonic inhalation of a 1% solution of the hydrolyzate of the placenta when the temperature of the solution 35°, per procedure 10 ml of solution for 10 minutes. Inhalation exercise in the morning on an empty stomach or after 40-60 minutes after eating. After inhalation additionally perform the scanning laser heate the output laser radiation when the output power at the end of the light guide 2 mW, the power flux density of 50 mW/cm2in the position of a patient lying on his stomach on the fields to the paravertebral left and right on the D3-D9the frame No. 31-39, the exposure time of 3 minutes, with the patient lying on his back on the field from the outer edge of the rectus abdominis muscle 1 cm below the edge of the right costal arch, over 1/3 of the distance from the middle of the right costal arch to the navel to the middle of the right hypochondrium, frame No. 64-66, the exposure time is 8 minutes. Inhalation and laser therapy are conducted daily for a course of 10 treatments.

The NOVELTY of INVENTIONS

- First proposed the ultrasonic inhalation of a 1% solution of the hydrolyzate of the placenta when the temperature of the solution 35°, per procedure 10 ml of solution for 10 minutes. Inhalation exercise in the morning on an empty stomach or after 40-60 minutes after a meal.

- After inhalation additionally perform the scanning laser infrared laser radiation when the output power at the end of the light guide 2 mW, the power flux density of 50 mW/cm2. With the patient lying on his belly on the fields paravertebral left and right on the D3-D9the frame No. 31-39, the exposure time of 3 minutes, with the patient lying on his back on the field from the outer edge of the rectus abdominis muscle 1 cm below the edge of the right costal arch, over 1/3 of the distance from the middle of the right R is Bernau arc to the navel to the middle of the right hypochondrium, frame No. 64-66, the exposure time is 8 minutes.

The proposed method prevents the formation of pneumoconiosis in the early stages of COPD and increases the efficiency of treatment of patients with COPD in the form of dust bronchitis, the method prevents the reduction of working capacity of workers of the coal industry due to:

pronounced mucolytic effect on the viscosity of sputum;

- increase the level of activity of secretory enzymes and immunoglobulins;

- increase the functional activity of the epithelial cells;

- normalization escalator-evacuation function of columnar epithelium and bronchial drainage function;

fast relief of inflammatory manifestations of the bronchopulmonary tract.

Criterion impact on segmental region and the region of the liver infrared laser radiation was the mechanism of action of factor: as a result of local thermal effect increases microcirculation and increase metabolic processes that enhance the overall adaptive response of the body. Pathological changes in the tissues are eliminated primarily congestion, reduced perifocal edema, reduced inflammatory and autoimmune reactions, strengthens the barrier function of lymphoid tissue. At the same time amplification enzyme and free radical processes,increases the content of bioactive compounds in free form. Shifts in transcapillary exchange, permeability gistogematicheskih barriers, metabolism of biologically active compounds, including cyclic amp and prostaglandin, which positively affects the course of regenerative and immune processes, functions immunocompetent tissue, oxidation-reduction reactions, tissue respiration, and oxygen homeostasis, inhibiting inflammation. The combination of the impact locally on the segmental area and the area of the liver causes the system dermato-visceral response by stimulating sensitive to this factor of the hypothalamus and pituitary. Their reaction is characterized by activation of nonspecific resistance in response to exposure of the liver (V.s.ulaschik, Ivelocity. General physiotherapy. - Minsk. The book house. - 2003. - s.162-165).

The criterion for choosing the methods of IR laser irradiation of the scanning beam has served as accessibility, ease of implementation and the absence of laser burden on staff, as it was used auto release procedures using computer programs. Use a static figure, which is peculiar to move the laser beam path, occupying only a fraction of the total area of impact. Irradiated field size less than 80 cm2and the total area per procedure is not revised 400 cm 2that prevents the possibility of an overdose on the procedure.

The selection criteria of low-intensity infrared laser radiation was the effect of the biophysical impacts of electromagnetic radiation in the infrared range in tissue of a living organism and pharmacological agents, as well as the penetration depth (up to 7 cm). So when exposed to infrared laser radiation on medicine in the depth of the body change their physico-chemical properties. The effect of photophoresis allows you to use the minimum dose of the drug (reducing their introduction on 6-15% or using homeopathic solution concentration), while maintaining and enhancing its pharmacological properties that allows you to limit the drug load on the organism as a whole (Samosyuk I.Z., Lysenok VP, Loboda M.V. Laser therapy and laser puncture in clinical and medical practice. - K.: Health, 1997, 284 S., Isakov V.L. Application of lasers in biology and medicine: Sat. method, guidelines, methodologies and scientific. Dokl. in laser medicine. - K., 1996. - p.46-51). Laser radiation in the infrared (IR) range in therapeutic doses acts at the molecular level: stimulates redox processes, increases the rate of protein synthesis, enzymes; at the cellular level: changes in membrane potential, increases the proliferative activity; on the cloth is the first level: changes the pH of the interstitial fluid, increases microcirculation; at the organ level: normalizes the function of the body (the result of reflex responses), and also causes generalized reaction (activation of the endocrine glands and the immune systems). Laser IR radiation is absorbed mainly by the nucleic acid molecules of oxygen without causing pronounced photochemical effect, and causing labetalol effect, which leads to the formation of free radicals, activation of enzymes that trigger physiological responses at the tissue level. Low-intensity infrared laser radiation stimulates the functional activity of the capillaries due to their dilatation and disclosure backup. With repeated sessions of laser therapy there is an increase in capillary network - neovasculgen (the formation of new capillaries). Under the influence of IR laser radiation the rate of regeneration of microvessels increased twice (Bolin V.A., Kozlov V.I., Litvin GD the Use of infrared laser radiation in the treatment of hypertension: Method. rivers. - M., 1996. - c.3-5). When exposed to IR laser radiation on the area of the segment improves circulation of the spinal cord, roots and reticulonodular of the arteries, which helps to normalize functionally dependent organ (in this case, bronchial tree and lungs in General), and inflammatory the phenomena occur without increasing the quantitative ratio of fibrous tissue. This mechanism prevents the development of pneumosclerosis in the lung tissue, causes activation of plastic processes and accumulation of macrophages, vasodilatation and normalization of local blood flow, increases the dehydration of the tissues in inflammatory lesion, stimulates reparative processes in the lungs, increases Depository activity of neutrophils. As a result - increased nonspecific resistance to adverse environmental factors, restores the mechanism of sangeeta. (Ushakov A.A. Modern physiotherapy in clinical practice. - ARMY.- Moscow. - 2002. - p.124-126).

The selection criteria aerosols of 1% solution of the hydrolyzate of the placenta was pathogenetic validity of the method effects on the mucous membrane of the respiratory tract in chronic inflammatory diseases of the respiratory system inhalation of drugs anti-inflammatory, stimulating, immunomodulatory nature. (Lghzv. "Effective use of placental preparations", Angarsk, 2005). The drug placentae obtained from the placenta of cattle, developed by a team of creators and scientists on the basis of production "Company yalma when overflowing with subsequent laboratory and clinical testing center of plastic surgery and cosmetology MOH of Russia (certificate No. SSES. EN. The CSCS. 158. The state the state register №ROSS RU. 0001.510346). The product contains highly active peptides, amino acids, mucopolysaccharides, hyaluronic and nucleic acids, trace elements. These components provide a powerful antioxidant effect, stimulating not only the processes of local immunogenesis, regeneration and phagocytosis, but also a tonic to the Central nervous system, improve heart muscle. (Recommendations for use of Wellness products. - edited Deriglazova N.A. - Company "yalma when overflowing". - Moscow. - 2006. - 39). The penetration of particles of the aerosol placentae in the bloodstream and regional lymph gland has significant immunomodulatory effect not only on the local nonspecific protective epithelial barrier, but also on systemic immunity in General.

For comparison presents the similar parameters of the main and control groups. The study group included 40 patients, workers of the coal industry with COPD in the form of dust bronchitis varying severity treated by the present method. The control group consisted of 38 patients with COPD in the form of dust bronchitis treated according to the prototype. As can be seen from table No. 1, No. 2, No. 3, the functional state of the respiratory and mucous membrane of the respiratory tract in particular indicators of local immunity, significantly in oceesa under the influence of aerosol therapy 1% solution of the hydrolyzate of the placenta and subsequent irradiation of infrared laser segmental zones and the liver all patients, which proves the high immunocorrective effect of the proposed method.

The use of exposure inhalation of 1% solution of the hydrolyzate of the placenta and subsequent irradiation of infrared laser segmental zones and the liver in patients with COPD in the form of dust bronchitis allowed to obtain new result:

- the disappearance of cough for 5 procedure and normalization of respiratory rate, as judged by clinical course during the observation period (table 3) compared with the control, where the cough disappeared only to 8-9 procedure (P<0,001);

- saniyede sputum after 3 treatments with Muco-purulent viscous character to mucous moderate viscosity of nature, in contrast to the control group, in which the signs of inflammation were stopped only to 14 days from the start of treatment (number of neutrophils in smears-cytograms after treatment in the main group reached standards: 19,1±1,7% compared to 30.3±1.7% in control, P<0.01, table 2);

- stimulated by neurohumoral mechanism for ecoscreen contributing to the dilution effect of sputum (after treatment the amount of protein in the sputum is 2.3 times lower compared to the prototype P<0,01: the amount of total protein in natalem secret after treatment in the main group was 1.7 mg/ml (normal 1,22±0.09 mg/ml P>0,5); and the concentration of total protein in the sputum of 2.3 mg/ml (at a rate of 1.77 in�B1; 0.15 mg/ml P>0.5 in). Accordingly, at similar rates in patients of the control group, these data were: 3.7 mg/ml and 4.3 mg/ml, P<0,001, Tables 1 and 2);

- increases the drainage function of the mucous membrane of the respiratory tract compared to the prototype (after treatment in patients of the main group mucociliary clearance is 17.8 minutes against 34.6 minutes in the prototype, P<0,01 at the rate of 14.7±1.1 minutes, Tables 1 and 2);

- stimulates the regenerative function of the integrity of the epithelial barrier of the mucosa of the respiratory tract (after treatment in the main group type of cellular destruction of cytograms were defined as II, while in the control group as III-type IV (P<0.01, Table No. 1 and No. 2);

- normal functional activity of the squamous epithelium (APE) and neutrophils (FAN), alveolar macrophages (FOAM) (after treatment in the main group, these figures were: APE 18,4±1,7; FAN 17,7±1,2; FOAM - 25,3±1,4 against the same parameters of the control group: APE 10,4±1,1; FAN 11,7±1,6; FOAM and 15.3±1,9, P<0.01, Table No. 1 and No. 2);

- increased secretory activity of nonspecific factors of protection of the mucous membrane of the respiratory tract (lysozyme activity of nasal secretion (AL) and the concentration of secretory immunoglobulin a (SIgA) in the study group after treatment almost normal which was ovalis, while in the reliable control performance was not determined: AL - became 59,1±1.1%, and the concentration of SIgA 0.18 g/l vs. 25.3 per cent and 0.11 g/l, respectively, in the prototype, P<0.01, Table No. 1 and No. 2);

increases the period magnetizing period: up to 7-8 months, which is more than 7 times more compared to the prototype (P<0,01);

- reduced the amount of inhaled mucolytics are presented and broncholytics per day (1 every 1-2 days, not 2 times a day compared to the prototype P<0,01).

The method is as follows.

Effect of physiotherapeutic factor, by inhalation of 1% solution of the hydrolyzate of the placenta in the form of aerosols from the ultrasonic inhalation therapy. Inhalation exercise in the morning on an empty stomach or after 40-60 minutes after eating through the inhalation tube, in the absence of concomitant pathology of the nasal cavity. In cases of manifestations of chronic processes in the paranasal sinuses (ethmoiditis, sinusitis) for inhalation use a mask. The solution before the procedure warm up (if the machine without heating) up to 35°C. one procedure is released to 10 ml of solution, which the patient breathes for 10 minutes. The procedure is performed daily, the course consists of 10 sessions. Immediately after inhalation additionally released the procedure of scanning the laser therapy apparatus of the "Stimulator laser ska is yuushi physiotherapy infrared laser radiation when the output power at the end of the light guide 2 mW, the power flux density of 50 mW/cm2, with the patient lying on his belly on the fields paravertebral left and right on the D3-D9the frame No. 31-39, the exposure time of 3 minutes (the shape of the frame No. 31-39 is a vertical segment, oscillating with a frequency of 1 HZ (Stimulator laser scanning physiotherapy SLSF-IC" EISH 1536.203, GOST 15150, production JV "ROCK", St. Petersburg, issue 01.1995 g)), in the supine position on the field from the outer edge of the rectus abdominis muscle 1 cm below the edge of the right costal arch, over 1/3 of the distance from the middle of the right costal arch to the navel to the middle of the right hypochondrium, frame No. 64-66, time exposure to 8 minutes. Treatments were carried out daily for a course of 10 treatments. The shape of the frame No. 64-66 represents the scan with the slow transformation of the oval in line ("Stimulator laser scanning physiotherapy SLSF-IC" EISH 1536.203, GOST 15150, production JV "ROCK", St. Petersburg, issue 01.1995 year).

Under supervision there were 40 people at the age from 30 to 47 years, men who are engaged in the development of coal seams underground. All patients were admitted to the rehabilitation therapy regarding exacerbation of COPD dust bronchitis. All patients had experience in coal mining underground work above 5 years. All patients were examined before andafter treatment studies of local immunity of the mucous membrane of the nose and phlegm: the concentration of secretory immunoglobulin A (SIgA) and lysozyme activity (AL), as well as counting cytograms smears, fingerprints nasal secretions and sputum to determine the cellular composition (cylindrical epithelial (CKP) and blaskapelle (PE) cells, alveolar macrophages (AM), neutrophils (N) and their functional activity: FUN, FOAM and the degree of their degradation (DCD type of cytograms). For comparison presents similar figures 38 patients of the control group treated according to the prototype.

Laboratory studies before treatment revealed a pronounced defect factors of local immunity in patients of the two groups (table 1). So a significant lack of secretory IgA (p<0.01) in natalem secret was accompanied by a high destructive processes of cells of all types (cylindrical and flat epithelium, neutrophils). Differentiated destruction they columnar epithelium (DTDCA), they differentiated destruction squamous epithelium (DDPA), they differentiated destruction of neutrophils (DCDN) matched III-IV type (normal I-type II), which contributed to the low functional activity of epithelial cells. So the adsorption of the squamous epithelium (APE) and the functional activity of neutrophils (FAN) were reduced by 3-5 times compared to normal (table 1). The data reliably indicate the expressed violations of the protective barrier function of mucus is the membrane of the respiratory tract throughout in patients with COPD in the form of dust bronchitis (pneumoconiosis). After a course of rehabilitation in the two groups noted a positive trend (table 2). In natalem secret all patients are defined positive changes with decreasing destructive cellular processes and to improve the functional activity of columnar epithelial cells (CKP) and neutrophils (N). At the same time, in the main group according to the examination results are significantly better than the control. So, in patients treated by the present method, the concentration of SIgA in natalem secret normalized, and patients of the control group only marked increase (P<0,01). Regenerative processes of the cells in smears from the mucous membranes of the nasal cavity were higher in patients of the main group (p<0,001), which was accompanied by a transition DCD COE, DCD PE and DCD N II type. While the functional activity of the squamous epithelium (PE) and N mentioned above 1.5 times. The number of neutrophils in the sputum of patients of the main group decreased to normal. When this was increased to a natural limit to the number of functionally active AM, compared with the index in the prototype, due to the stability of the cells (differentiated they destruction (DCD AM) type II), and, consequently, improve the quality of phagocytosis.

Clinical observations showed a high therapeutic effect of the rate claimed is the procedure of rehabilitation. However, in the main group all symptoms disappeared for 6-7 days earlier than in the control.

The results showed that the proposed method has a pronounced positive effect on the recovery of the functional state of the epithelial barrier of the mucosa of the respiratory tract in workers coal mining, raising nonspecific resistance systemic and local immunity, and evacuation function of epithelial cells, improving the drainage of the bronchi, providing rapid relief of inflammation in the lungs and bronchi (Table№1, №2, №3).

Figures research of the state of local immunity, studies of the nasal mucosa and sputum: the concentration of secretory immunoglobulin a and activity of lysozyme, counting cytograms smears, fingerprints nasal secretions and sputum to determine the cellular composition (epithelial and blaskapelle cells, alveolar macrophages, neutrophils and their functional activity) and the extent of their degradation (DCD type of cytograms) before and after treatment in patients of the main group demonstrate the Express restore the epithelial barrier of the respiratory system compared with patients in the control group who did not receive rehabilitation treatment for the proposed method (Table №1 and №2)

EXAMPLE No. 1. Patient A., Aged 38. Diagnosis at admission: chronic obstructive pulmonary disease: occupational bronchitis, exacerbation. From the anamnesis it is known, that works miners work underground in coal production for 9 years. Considers himself ill for 6 years, when he became ill from colds with symptoms of bronchitis 2-3 times a year. In the last 3 years worried about a persistent cough with sputum, especially in the morning, which has a yellowish or green viscous character. Acute bronchitis is currently not depend on the presence of viral infections, always accompanied by severe shortness of breath requiring admission broncholytics. Upon receipt marked pallor of the skin and orbital cyanosis, shortness of breath. Auscultation over the lungs can be heard scattered moist rales of an impermanent nature. Before treatment studies of mucociliary clearance revealed the increase to 28 minutes (at a rate of 14.7±1.1 min, P<0,001); the amount of total protein in natalem secret was 3.7 mg/ml (normal 1,22±0.09 mg/ml, P<0,001); the concentration of total protein in the sputum of 4.3 mg/ml (at a rate of 1.77 in±0.15 mg/ml, P<0,001). The number of neutrophils in sputum smears examined exceeded the normal tenfold: 56% at the rate of 2.2±0,6% (P<0,001). they a nasal smear imprint had type IV degradation instead of III in normal (P< 0,001). The functional activity of alveolar macrophages (FOAM) corresponded to 10.9% (at a rate of 32.4±4.4%). Were assigned to the treatment in accordance with the inventive method, according to which the effect of physiotherapeutic factor of 1% solution of the hydrolyzate of the placenta in the form of aerosols from the ultrasonic inhalation therapy. Inhalation was performed in the morning on an empty stomach through the inhalation tube. The solution before the procedure warmed up to 35°C. one procedure is released to 10 ml of solution, which the patient breathed for 10 minutes. The procedure was performed daily, the course consisted of 10 treatments. Immediately after inhalation additionally performed procedure scanning infrared laser therapy apparatus of the "Stimulator laser scanning physiotherapy" for the output power at the end of the light guide 2 mW, the power flux density of 50 mW/cm2with the patient lying on his stomach on two fields paravertebral left and right on the D3-D9the frame No. 31-39, for 3 minutes on the field. Translated patient in the supine position. Worked on the box from the outer edge of the rectus abdominis muscle 1 cm below the edge of the right costal arch, over 1/3 of the distance from the middle of the right costal arch to the navel to the middle of the right hypochondrium, frame No. 64-66, the exposure time is 8 minutes. Pried the market held daily, in the course of 10 treatments.

After 3 treatments cough became rare in the lungs no rales were heard, sputum became less viscous, the number has decreased in 2 times, her character became slimy. Was cancelled evening reception mucolytic and bronchodilator drugs.

When the study results after the end of treatment revealed a significant positive trend: mucociliary clearance was 18 minutes, the concentration of total protein in natalem secret - 2 mg/ml, and in the sputum - to 2.65 mg/ml; number of neutrophils decreased to 10%; FOAM increased to 29.3% (P<0,01). Cell destruction was practically absent (DZD all types of cells corresponded II type). Symptoms were cropped to 5 the procedure.

Example No. 2. Patient B. case History No. 168. Age 37 years. Diagnosis at admission: Chronic obstructive pulmonary disease: occupational bronchitis, exacerbation. Concomitant diagnosis: Chronic bilateral sinusitis, the period of incomplete remission. From the anamnesis it is known, that works miners work underground in coal production for 11 years. Considers himself ill for 5 years, when he became ill from colds with symptoms of bronchitis to 3-4 times per year. In the last 2 years worried about a persistent cough with sputum, especially in the morning, which has a yellowish or green viscous character. Constantly have the tsya runny nose and periodically treated over the bilateral sinusitis the ENT doctor. It is registered for this disease. Acute bronchitis is currently not depend on the presence of viral infections, always accompanied by severe shortness of breath requiring admission broncholytics, antibiotics. Upon receipt marked pallor of the skin and orbital cyanosis, shortness of breath. Auscultation over the lungs can be heard scattered moist rales of an impermanent nature. Nasal breathing is difficult. When Bismarckian and the expectoration has a detachable character Muco-purulent character. Before treatment studies of mucociliary clearance revealed the increase to 32 minutes (at a rate of 14.7±1.1 min, P<0,001); the amount of total protein in natalem secret was 3.9 mg/ml (normal 1,22±0.09 mg/ml, P<0,001); the concentration of total protein in the sputum of 4.8 mg/ml (at a rate of 1.77 in±0.15 mg/ml, P<0,001). The number of neutrophils in sputum smears were above normal in dozens of times: 67% at the rate of 2.2±0,6% (P<0,001). they a nasal smear imprint had type IV degradation instead of I-II in normal (P<0,001). The functional activity of alveolar macrophages (FOAM) corresponded to 8.9% (at a rate of 32.4±4.4%). Were assigned to the treatment in accordance with the inventive method, according to which the effect of physiotherapeutic factor of 1% solution of the hydrolyzate of the placenta in the form of aerosols from ultra is Bokovoy inhalation therapy. Inhalation was performed in the morning after 40-60 minutes after eating through the mask, as there is pathology of ENT organs (bilateral sinusitis). The solution before the procedure warmed up to 35°C. one procedure was released to 10 ml of solution, which the patient breathed for 10 minutes. The procedure is performed daily, the course consisted of 10 treatments. Immediately after inhalation was additionally released the procedure of scanning infrared laser therapy apparatus of the "Stimulator laser scanning physiotherapy" for the output power at the end of the light guide 2 mW, the power flux density of 50 mW/cm2in the position of a patient lying on his stomach on two fields paravertebral left and right on the D3-D9the frame No. 31-39, for 3 minutes on the field. Then he translated the patient in the supine position and worked on the field from the outer edge of the rectus abdominis muscle 1 cm below the edge of the right costal arch, over 1/3 of the distance from the middle of the right costal arch to the navel to the middle of the right hypochondrium, frame No. 64-66, the exposure time is 8 minutes. Treatments were carried out daily for a course of 10 treatments.

After 4 treatments cough became rare, sputum less sticky, the number has decreased in 2 times, her character became slimy. When the study results after the end of treatment revealed a significant positive dynamics is: mucociliary clearance was 18 minutes the concentration of total protein in natalem secret - 2.1 mg/ml, and in the sputum of 2.5 mg/ml; number of neutrophils was reduced to 11%; FOAM increased to 25.3% (P<0,01). Cell destruction was practically absent (DZD all types of cells corresponded II type). Symptoms were cropped to 5 the procedure, and was cancelled evening reception mucolytic and bronchodilator drugs.

The effect obtained from the proposed method, which consists in the following:

1. Fast relief of the inflammatory process in the lung.

2. Pronounced secretolytic effect with significant liquefaction of sputum.

3. High draining effect of the bronchial tree.

4. The normalization of the state of local immunity of the mucous membrane of the respiratory tract.

5. Reducing the number of daily nutrient intake mucolytics are presented, broncholytics inside and inhaled.

Table 1
Indicators of nonspecific factors of protection of the mucous membrane of the respiratory tract in patients of two groups before treatment (X±Δ)
IndexThe main group (n=40)Control group (n=38)NormaThe reliability of differences with the norm (R)
Mucociliary clearance (MK-minutes) 5,1±0,95,1±1,114,7±1,1<0,001
Lysozyme activity (AL - %)21,4±4,824.5±3,172,4±6,1<0,001
The SIgA concentration (g/l)0,09±0,070,08±0,090,22±0,08<0,001
The number of neutrophils in the cytograms (N %)9,4±1,79,3±1,221,7±3,2<0,001
The functional activity of neutrophils (FAN%)3,4±1,14,4±1,618,9±3,7<0,001
Adsorbsia squamous epithelium (APE, %)9,1±1,97,9±0,919,7±6.2<0,001
The functional activity of alveolar macrophages (FOAM,%)13.1±5.510.9±4.632.4±4.4<0,001
Differentiated destruction they columnar epithelium (DCD CKP)IVIVI-II<0,001
Differentiated destruction they squamous epithelium (DCD PE)IVIVI-II<0,001
Differentiated they des is the construction of neutrophils (DCD N) IVIVI-II<0,001
Differentiated they destruction of alveolar macrophages (DCD AM)IVIVI-II<0,001

Table 2
Indicators of nonspecific factors of protection of the mucous membrane of the respiratory tract in patients of two groups after treatment (X±Δ)
IndexThe main group (n=40)Control group (n=38)No significant difference between the performance of the two groups (P)
MK (minutes)11,7±1,47,4±0,9<0,001
AL (%)68,6±3,132,7±4,4<0,001
The SIgA concentration (g/l)0,18±0,030,11±0,04<0,01
N in cytograms (%)18,1±1,711,1±0,7<0,01
FAN (%)17,7±0,0810,0±0,5<0,01
APE (%)18,4±0,79,6±1,1<0,001
FOAM (%)29.3±2.418.4±4.2<0,00
DCD COE (type)IIIII-IV<0,01
DDPAIIIII-IV<0,01
DCD HIIIII-IV<0,01
DCD AMIIIII-IV<0,01

Table 3
Indicators of clinical course before and after treatment in patients of the two groups
IndexThe main group (n=40)Control group (n=38)
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatment
The presence of coughFrequentNoFrequentRare
The amount of sputumA lotNoA lotThe meager amount
The character of the sputumPurulent mucous-Purulent mucousSlimy, viscous
The presence of wheezingFickle wet and dry over both lungsnoFickle wet and dry over both lungs Single rare in forced inhalation and exhalation

A method of treating chronic obstructive pulmonary disease in the form of dust bronchitis in workers of the coal industry, including ultrasonic inhalations, characterized in that the ultrasonic inhalations use 10 ml of 1% solution of the hydrolyzate of the placenta and spend it when the temperature of the solution 35°C for 10 min in the morning on an empty stomach or after 40-60 minutes after eating, and then optionally perform the scanning laser infrared laser pulses from the stimulator laser scanning physiotherapy - SLSF-IC when the output power at the end of the light guide 2 mW, the power flux-density of 50 mW/cm2with the patient lying on his belly on the fields paravertebral left and right on the D3-D9, frame No. 31-39, for 3 minutes on each field, and then - with the patient lying on his back on the region of the liver, frame No. 64-66, within 8 min, in the course of 10 treatments daily,



 

Same patents:

FIELD: medicine; pulmonology.

SUBSTANCE: baseline therapy is combined with introduction of Ronkoleukine inhaled in dosage 250 thousand ME with using nebuliser, and injected simultaneously. Introduction takes two stages, herewith at the first stage Ronkoleukine is injected intravenously drop-by-drop in dosage 250 thousand ME within course 3 procedures every 72 hours, while at the second stage Ronkoleukine is injected every 2 weeks hypodermically in external surface of a shoulder in dosage 250 thousand ME within course 4-6 procedures.

EFFECT: normalised immune disorders and relieved endobronchial inflammations.

2 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: in this invention, proposal is given of P2X7 receptor antagonists with formula (IA), or its pharmaceutical salt or solvate, where p stands for 0, 1 or 2; each of R1 independently stands for halogen or C1-6alkyl, possibly substituted by at least one substitute, chosen from hydroxyl, halogen and C1-6alkoxy ; q stands for 0, 1 or 2; each of R4 independently stands for halogen or C1-6alkyl, possibly substituted with at least one substitute, chosen from hydroxyl, halogen and C1-6alkoxy; m stands for 0, 1, 2 or 3; X stands for -C(O)NH- or -NHC(O)-; n stands for 1 or 2; in each CR5R6 grouping, each of R5 and R6 independently stands for hydrogen, C1-6alkyl, or R5 and R6 together with a carbon atom, to which they are both bonded, can form a 3-6-member cycloalkyl ring; R2 is a 4-9-member cycloalkyl ring system, which can be substituted; one of Y or Z is nitrogen, and the other is a CR3 group, where R3 is a group with formula (IIA) where X1 is an oxygen or sulphur atom, or a N-R11 group, where R11 is hydrogen or a C1-5alkyl group, which can be substituted; R9 is a bond or C1-5alkyl group, which can be substituted; R10 is hydrogen, hydroxyl, carboxyl, -C(O)OR20, -NR21R22, -C(O)NOH or a -WR23 group; or R10 is a 4-9-member carboxylic or heterocyclic ring, each of which can include bridge groups. The carboxylic or heterocyclic ring can be substituted. R21 and R22 are independently chosen from hydrogen, C2-7alkenyl, C1-6alkylcarbonyl, -SO2R46, -C(O)NHSO2R47, 3-8-member carboxylic or heterocyclic ring, which can be substituted, or R21 and R22 can stand for a C1-7alkyl group, which can be substituted; W and W' independently stand for a bond, O, S(O)p, -NR57C(O)-, -C(O)NR58-, -SO2NR59, -NR60SO2-, >NR61, C1-6 alkylene or a -O(CH2)1-6- group, -S(O)p(CH2)1-6-, -NR62(CH2)1-6-, -(CH2)1-3O(CH2)1-3-, -(CH2)1-3S(O)p(CH2)1-3-, (CH2)1-3NR63(CH2)1-3-, -(CH2)1-3NR64C(O)(CH2)0-3-, -(CH2)1-3C(O)NR65(CH2)0-3- or -S(O)p(CH2)1-6NR66-; p stands for 0, 1 or 2; R23 and R24 independently stand for a 3-10-member carboxylic or heterocyclic ring, containing 1-5 heteroatoms, independently chosen from nitrogen, oxygen and sulphur, which can be substituted; each of R7, R8, R12, R13, R14, R15, R16, R17, R18 and R19 independently stand for a hydrogen atom or a C1-6alkyl group, possibly substituted with at least one substitute, chosen from hydroxyl, halogen and C1-6alkoxy, or any of R7 and R8, R14 and R15, R16 and R17 together with a nitrogen atom, to which they are both bonded, can form a 3-8-member saturated heterocyclic ring; each of R20, R34, R37, R46, R47, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67 and R68 independently stands for hydrogen or C1-6alkyl group, which can be substituted; each of R25, R26, R27, R28, R30, R31, R32, R33, R35, R36, R38, R39, R40, R41, R42, R43, R44, R45, R48, R49, R50, R51, R52 and R53 independently stands for a hydrogen atom or C1-6alkyl, C2-6hydroxyalkyl or C3-8cycloalkyl group, or any of R25 and R26, R27 and R28, R38 and R39, R41 and R42, R48 and R49, R50 and R51 together with a nitrogen atom, to which they are both bonded, can form a 3-8-member saturated heterocyclic ring; and R29 is an aryl. Description is also given of the method of obtaining formula IA compounds, pharmaceutical compositions containing these compounds, treatment method based on these compounds and their use in therapy.

EFFECT: obtaining new compounds with useful biological properties.

16 cl, 114 ex

FIELD: medicine.

SUBSTANCE: autoblood is daily sampled in patient as 2 ml/kg of weight. Sampled blood is mixed with 20 ml of 0.06% sodium hypochlorite with further ultraviolet radiation with the help of "Isolda" device for 20 minutes. Then blood is intravenously injected to by drop infusion. Treatment is carried out daily for 5 days.

EFFECT: enhanced efficiency of treatment of patients with chronic obstructive bronchitis.

2 ex, 2 tbl

FIELD: medicine; pulmonology and pediatrics.

SUBSTANCE: drug for elimination of airway hyperreactivity contains medication inhaled into breathing passages, at that Konstantinovskaya-1 mineral water is inhaled, which is related to mineralised (extent of mineralisation is 1.5-2.0 g/l) waters of chloride-sodium composition.

EFFECT: positive correction of airway hyperreactivity in children and prevention of complications related to medical correction of this pathology.

2 ex

FIELD: chemistry.

SUBSTANCE: invention claims derivatives of pyridazin-3(2H)-one of formula (I), where R1, R2 and R4 are organic radicals described in the claim 1, R3 is cyclic group described in the claim, and R5 is phenyl or heteroaryl group described in the claim. Compounds of formula (I) inhibit phosphodiesterase 4 (PDE-4) and can be applied in treatment of various diseases or pathological states alleviated by PDE-4 inhibition, and in medicine production for treatment of aforesaid diseases. Also invention claims method of obtaining these compounds and intermediate compounds for their obtainment.

EFFECT: obtaining compounds which can be used in treatment of various diseases or pathological states and in medicine production for treatment of aforesaid diseases.

25 cl, 28 tbl, 243 ex

FIELD: chemistry.

SUBSTANCE: invention claims derivatives of pyridazin-3(2H)-one of formula (I), where R1, R2 and R4 are organic radicals described in the claim 1, R3 is cyclic group described in the claim, and R5 is phenyl or heteroaryl group described in the claim. Compounds of formula (I) inhibit phosphodiesterase 4 (PDE-4) and can be applied in treatment of various diseases or pathological states alleviated by PDE-4 inhibition, and in medicine production for treatment of aforesaid diseases. Also invention claims method of obtaining these compounds and intermediate compounds for their obtainment.

EFFECT: obtaining compounds which can be used in treatment of various diseases or pathological states and in medicine production for treatment of aforesaid diseases.

25 cl, 28 tbl, 243 ex

FIELD: chemistry.

SUBSTANCE: description is given of a piperidine derivative with general formula (I) , where L represents CH or N; M represents CH or N; under the condition that, L and M both do not represent CH; R1 represents phenyl (possibly substituted with a halogen or C1-4alkyl), S(O)2(C1-4alkyl), S(O)2(C1-4fluroalkyl), S(O)2phenyl (possibly substituted with CF3 or OCF3), benzyl, benzoyl (possibly substituted with a halogen) or C(O)NHphenyl (possibly substituted with a halogen); R2 represents phenyl, possibly substituted with a halogen; R3 represents hydrogen or C1-4alkyl; R4 represents methyl or ethyl; R5 represents phenyl-NH, phenyl (C1-2alkyl), phenyl(C1-C2)alkyl-NH or pyridyl(C1-2alkyl). The phenyl can be substituted with a halogen, cyano, C1-4alkyl, C1-4alkoxy, S(O)k(C1-4alkyl) or S(O)2NR8R9; k is equal to 2; R8 and R9 represent hydrogen or its pharmaceutical salts. The compound is a modulator of the activity of the CCR5 receptor. Description is given of the method of obtaining the compound, where L represents N, and the pharmaceutical composition based on a compound with formula (I).

EFFECT: design of a method of obtaining a compound, where L represents N, and a pharmaceutical composition based a compound with formula (I).

7 cl, 7 tbl, 16 ex

FIELD: medicine; otorhinolaryngology.

SUBSTANCE: preparation pyobacteriophage polyvalent purified liquid is injected in maxillary sinus in amount 5-10 ml twice a day, every 12 hours within 6 days. Besides, from the first day of treatment, the preparation is introduced intranasal dosed 3 ml twice a day within 21 days.

EFFECT: long remission of disease resulted from restored adequate immune response and absence of depressed condition of cellular representation of nasal and sinus mucous membrane, stable synthesis of secretory immunoglobulin class A, normalised indicators of phagocytosis completeness, maximal pathogen elimination from nasal and sinus mucous membranes.

2 tbl, 1 ex

FIELD: medicine; pulmonology.

SUBSTANCE: treatment of bronchial asthma, either intermittent or mixed of mild severity level is ensured with introduction of anti-inflammatory preparations being labrocyte stabilisers, combined with introduction of immunomodulators Polyoxidonium and Galavit. Herewith specified immunomodulators are introduced sequentially according to the certain schedule.

EFFECT: higher efficiency of treatment due to normalisation of immune system function and structural restoration of bronchi mucous membrane.

2 tbl

FIELD: medicine; physiotherapy.

SUBSTANCE: method includes remedy exercise, thorax massage, mineral water inhalation, peloid application. Additionally two zones are exposed to supertonic frequency current in turns by days. On one day head and collar zone are affected for 7-10 minutes at power up to 3 W, on the second day current with power up to 4-6 W is applied to thorax zone, to lower thorax compartments for 2-3 minutes from paravertebral to medium axillary line paravertebrally, along spine upside from down for 2-3 minutes from each side, along 6-8 intercostal space for 2-3 minutes. The whole course comprises 14-16 procedures. Peloid applications are performed on two areas in turn by days. On one day application is made at collar zone at +35°-+36°C, on the second day application is made at lower thorax part starting from shoulder blade corners at +38°-+40°C, application time is 20-30 minutes. The course comprises 6-7 procedures for each zone.

EFFECT: improved treatment efficiency and tolerance, reduced medicine strain, simultaneous effect on leading patogenetic links of both diseases.

2 ex, 10 tbl

FIELD: medical equipment.

SUBSTANCE: ultrasonic skin care apparatus contains the casing equipped with applicator head transmitting ultrasound to user's skin, and driver circuit transmitting electric closing pulse to applicator head operation thus generating ultrasound. The applicator head of the generator contains vibrator and flange with mounting surface and surface faced to skin. Herewith the vibrator is provided on the mounting surface of the flange thus integrating uniform vibratory gross forming the applicator which creates the first electric equivalent resistance in case of rated loading within skin contact and the second electric equivalent resistance without loading. Besides, the device is provided with load record circuit which controls, whether specified uniform vibratory gross generates the first electric equivalent resistance or the second electric equivalent resistance, and generates load record signal only it is detected that this is first electric equivalent resistance, and control circuit which limits or stops electric pulse generation if load record signal is not received within preset time. The uniform vibratory gross is provided to restrict vibrations in its centre thus reducing parasitic resonance.

EFFECT: ensured safety and higher efficiency skin effect in combined application of active skin preparation and ultrasound.

15 cl, 35 dwg, 1 tbl

FIELD: medicine, physiotherapy.

SUBSTANCE: in medical rehabilitation of dorsopathy patients with concomitant osteoarthrosis, prior to mud cure, magnetotherapy is conducted by pulse magnetic field: double impulses, 1300 mTl intensity, 110±10 mcs pulse duration, 20±5 Hz frequency, during 9 to 12 minutes, on areas of paravertebral muscles and muscles that move affected joints; summary number of fields being 4 to 6. 20 to 30 minutes later mud applications are conducted on affected spine parts and joints areas at temperature 30-40°C during 20 to 30 minutes. Then, 20 to 30 minutes later ultrasound therapy is conducted, 0.4-0.6 W/cm2 intensity, on musculo-tendinous pain zones in lumbosacral and periarticular areas during 8 to 12 minutes; summary number of fields being 2 to 4. Complex therapy is conducted daily and includes 8 to 10 procedures.

EFFECT: pain syndrome reduction, regional blood circulation improvement, affected neuromuscular apparatus stimulation.

3 tbl, 2 ex

FIELD: medicine; otorhinolaryngology.

SUBSTANCE: method includes influence on muscles of soft palate by carrying out low-frequency phonophoresis of neostigmine methylsulfate solution in three points. Two of them are located over the small uvula, on distance about 2 cm on the right and to the left of an average line of a soft palate and about 1 cm from a bottom edge of a curtain of a soft palate. The third point is located in the centre of the triangle formed at shift of tongue back and limited behind to tongue, and on each side - sublingual sialadens.

EFFECT: method is comfortable and simple in execution.

1 dwg, 2 ex

FIELD: medicine, gynecology.

SUBSTANCE: vulva sanitation is conducted. Then ultrasound exposure of vagina is conducted during 60 seconds, through intermediate antiseptic solution infused into the cavity. Whereupon 100 IU poludane dissolved in 5 ml sterile injection solution, is introduced into uterine cavity. At the same time ultrasound exposure of endometrium is conducted during 60 seconds. The low-frequency ultrasound with 26.5 kHz frequency and 50 mcm amplitude is applied in continuous mode. Treatment procedures are effected every morning at first phase of menstrual cycle, 1.5 to 2 hours after the meal. The course includes 5 procedures.

EFFECT: increased therapy efficiency due to complications reduction, steady treatment result, curing period shortening, and medicament load easing.

1 ex

FIELD: medicine.

SUBSTANCE: traditional treatment includes operative intervention with additionally detected phase of menstrual cycle for women of childbearing age. In case disease is developed in late folliculin phase, Clopidogrel is introduced orally in single dose 75 mg in the day of operation. Then alveolar process from vestibule of mouth cavity is covered with bolsters impregnated with 0.2% 5-oxy 4-methyluracyl in 10% dimethylsulphoxide within 15-20 minutes up to 5 times a day. And since the second day after operation phonophoresis method is applied daily in amount 10-20 ml within 5-7 minutes during 5 days.

EFFECT: provides improved rheological and coagulation properties of blood, correction of oral immunity that is accompanied with reduction of inflammatory process and short-term tissue regeneration after surgical intervention.

2 ex

FIELD: items of personal use.

SUBSTANCE: electric tooth-brush contains the handle, a head and the narrowed part located between the handle and the head. The handle has an internal cavity which contains the engine and power supply source, and the head contains the holder of a bristle and an element with power supplies, executed in the form of the ultrasonic converter. The ultrasonic generator is electrically connected with a source of power supply and supplied by the ultrasonic megaphone which is passing from the ultrasonic converter to a surface of a head, and the engine is functionally connected to shaft for movement of the holder of a bristle.

EFFECT: allows expanding an arsenal of means for cleaning of teeth and care of an oral cavity.

7 cl, 30 dwg

FIELD: medicine, equipment.

SUBSTANCE: invention concerns medical equipment, namely miniinvasive ultrasonic therapeutic processing of object in a body of the patient. The device for miniinvasive ultrasonic processing of object includes at least one therapeutic ultrasonic converter for processing of object by creation of the ultrasonic field, executed with possibility of formation of temperature focus (F) in object for its heating. The therapeutic ultrasonic converter contains a probe executed with possibility of input in a body in a direction of object of processing and having a forward part, intended for placing about object, opposite to it or in it, and also at least one radiating element for creation of an ultrasonic field. The radiating element is located in a back part behind a forward part of a probe, temperature focus (F) is located before a probe, and the forward part of a probe is executed heat sealing and contains focusing device for focusing of the ultrasonic field framed by the radiating element. The device is applied also to processing of a vertebral pulp in intervertebral disks or ligaments, for example in shoulders or knees.

EFFECT: decrease of risk of inadmissible thermal influence near to area of treatment of tissue.

27 cl, 3 dwg

FIELD: medicine; dermatology.

SUBSTANCE: spend mesotherapy of the stretch marks area with an admixture of preparations the tsel-T and kutis-kompozitum at 1:1. Carry out injections immediately in area of dermal defects on 0.1 ml of a solution through every 2-3 mm. Then perform phonophoresis of Lydasums in the stretch mark area within 10-15 minutes. Alternate the specified procedures in day with carrying out of applications of cosmetic clay on the stretch marks area within 30-40 minutes at temperature of 40-50°C.

EFFECT: method excludes possibility of occurrence of allergic reactions and is simple in execution.

2 ex, 4 cl

FIELD: medicine.

SUBSTANCE: invention concerns surgery and can be applied in staging cancer in vitro after oncological operations. Physiological solution is introduced into separated macrospecimen of fatty tissue in the amount of 10 ml per 20-30 mg of fat. Ultrasonic tissue cavitation is performed, glands and vessels are detected as a single unit. In a special case, ultrasonic tissue cavitation is performed by Soft Lipomodel liposuction medication certified by EEC under No 0068/ETl-DM/057-99.

EFFECT: improved integrity of lymphatic system architectonics, verification of small glands.

2 cl, 1 ex, 2 dwg

FIELD: medical equipment.

SUBSTANCE: piezoelement for a focusing ultrasonic head is made from piezoceramics in the form of a part of a spherical cover with an angle of disclosing of 180°. In top part of a spherical cover of a piezoelement is made the flat site, its thickness coincides with thickness of part of the spherical cover, and the parity of diameter of the flat site and the diameter of part of the spherical cover makes 15-25% for provision of maximum acoustic pressure in focal maculae on resonant frequency.

EFFECT: effective focusing of acoustic emission in a zone of geometrical focus of piezoelement.

7 dwg

FIELD: medicine; dentistry.

SUBSTANCE: treatment of inferior dental nerve neuritis caused by filling material delivery into mandibular canal is ensured with introduction of antibacterial agent before operation. Thereafter filling material is surgically removed from mandibular canal. Operation procedure is followed with introduction of antibacterial and immune correcting agents, antisensitisers, Reaferone, vitamins B1 and B12, adenosine triphosphate. Besides mandibular region is exposure to laser magnetotherapy with using dental apparatus Optodan, accompanied with intraoral HBO-therapy, hydromassage, hydrocortisone phonophoresis, 2% nicotinic acid solution amplipulse phoresis, Tambukan mud therapy, pine needle and pearl baths, acupuncture with using local and regional points.

EFFECT: higher treatment efficiency, restored blood circulation, accelerated rehabilitation, complete relief of evident pain syndrome and post-amputation pains, simplicity, efficiency.

3 ex

Up!