Method of nanostructurisation of bulk bio-compatible materials
SUBSTANCE: invention relates to laser equipment used for the purposes of nanotechnologies, particularly, to the methods of nanostructurisation of bulk bio-compatible nanomaterials by laser radiation. Nanostructurisation of the aforesaid materials is performed by laser irradiation of colloidal water-protein solution of carbon nanotubes till evaporation of the solution liquid component.
EFFECT: varying the properties of produced materials in a wide range and remote irradiation provides for biological purity of products.
The invention relates to the field of laser technology used in nanotechnological purposes, and in particular to methods of nanostructuring of bulk biocompatible nanomaterials under the action of laser radiation.
One of the important tasks of modern nanotechnology is the creation of artificial surgical implants of human organs. Commonly used for these purposes, endo - and ectoprocta short supply and expensive; metal implants must be replaced after a short operation by operating, causing pain and discomfort of patients; plastic implants are not strong enough and short-lived.
However, there is a fundamental possibility of solving these problems using the implants of the filling of nanomaterials, in particular, of compositions based on carbon nanotubes. As follows from the data [1, 2], carbon nanotubes can grow and develop nerve and bone cells. This opens up the path of self-Assembly of biological tissues at high strength nanotubes frame.
Known two-dimensional nanotrubki design, performed to the orientation of quartz and other substrates . However, a prerequisite of the use of nanomaterials to fill the implants is their production in the form of bulk compositions is s.
There is a method of laser irradiation for forming the convex structures on the surface of polymeric materials (effect of laser swelling) . However, in this case there are only the surface of the nanostructure, of a height of 0.1 μm when the diameter of about 0.2 μm, and the material is not biocompatible.
Closest to the proposed invention relates to the method of application of UV excimer laser to obtain anonymously beam structures on various materials. Such structures are, in particular, to create a neurosurgical microimplants for stimulation of neural tissues . However, in this case we are talking only about the surface nanostructure height of not more than 0.08 μm.
The present invention is to nanostructuring of bulk biocompatible nanomaterial under the action of laser radiation.
The method of nanostructuring of bulk biocompatible materials include laser irradiation of colloidal aqueous protein solution of carbon nanotubes until the evaporation of the liquid component of the solution.
The essence of the invention lies in the fact that thermal action of laser radiation allows to vaporize the liquid component of the solution and to obtain after evaporation of the liquid homogeneous composite nanomaterial cher the CSOs color, represents an ordered structure of aggregates of CNTS modified albumin.
Figure 1 shows a photograph of a glass vessel with nanomaterial obtained after evaporation of the liquid components of the colloidal aqueous protein solution of carbon nanotubes.
Figure 2 shows the measurement data of the film characteristics of the nanomaterial on a silicon substrate obtained by using a scanning probe microscope. On figa shows a diagram of the photodiode current, receiving the signal from the cantilever, which varies over the scanned surface. Figb demonstrates the character of the topography of the object in a similar scanning of the cantilever, the bright area was a hill, the dark region is deepening.
As can be seen from FIGU, the nanomaterial is a volumetric quasiperiodic composition round or toroidal globules with a diameter equal to 200-500 nm, and the visible height of 30-40 nm. The analysis charts the photodiode current indicates the electric charge of the material of the globules, which are rolled in a tangle of carbon nanotubes and their separating layer - modified albumin.
Figure 3 shows a method of laser irradiation of colloidal aqueous protein solution of carbon nanotubes. Figa shows the location of the vessel with the solution relative to the origin of the radiation is con - diode laser with optical output (λ=0,97 μm, N≤10 W), equipped with a light pointer. On figs shows the vessel with the solution, osveschennaja designator (green emission).
An important advantage of laser nanostructuring is distanced action that eliminates insertion of pollution and to ensure the biological purity of a nanoproduct.
The composition of the composite, consisting of a biocompatible component, and provides the biocompatibility of the obtained product, which can be used as a fill material for surgical implants.
The advantage of nanomaterial obtained after evaporation of the liquid components comprising the solution is also possible to vary the consistency of the nanomaterial from the glass - to pasty depending on the intensity and duration of laser irradiation. Glassy nanomaterial convenient for immediate use in the composition of the surgical implant. Pasty nanomaterial convenient for its application operated on the surface of the biological tissue with subsequent laser welding it with a cloth.
One promising area of application of the paste-like nanomaterial is the treatment of congenital malformations (CDF) of a person. One of the most dissemination is anenih species CDF are malformations of the maxillofacial area, 90% of them are congenital clefts of the upper lip and/or palate. The problem of treatment VLOOKUP particularly urgent against the background of trends, on the one hand, to the decrease in total fertility and, on the other hand, to increase the number of children with VLOOKUP, which is 1-12% of all newborns.
The practical applicability of the proposed method of nanostructuring of bulk biocompatible nanomaterial is illustrated in the following stages of manufacture and the results of investigation of the nanostructure of the material.
1. Stage 1. In distilled water dissolve albumin in a concentration of from 10 to 50% and then the solution was dispersed in an ultrasonic bath at a temperature of 40-50°until a homogeneous colloidal solution of albumin, usually within 1-2 hours.
2. Stage 2. In the solution from step 1 enter the carbon nanotubes at a concentration of 1-5 g/l and then, the solution was placed in an ultrasonic bath and dispersed within 3-5 hours to obtain a homogeneous colloidal aqueous protein solution of carbon nanotubes black.
3. Stage 3. The solution from stage 2 is poured into a glass vessel and irradiated with laser light for 10-30 min until complete evaporation of the liquid components of the solution and a homogeneous composite nanomaterial black.
Sources of information
1. US Patent No.6.670.179.
2. Cancers EG Nanatsu the key and fullerenes. // M: University book, Logo, 2006
3. L..Zanello, B.Zhao, NNi, R..Haddon. - Nano Letters, 2006, v.6, n.
4. Ajomale, Nimbidin. - Izv. Higher education INSTITUTIONS. Instrumentation, 2006, v.49, No. 9, p.9.
5. US Patent No.6.853.075.
The method of nanostructuring of bulk material, characterized in that conduct laser irradiation of colloidal aqueous solution of albumin containing carbon nanotubes, until evaporation of the liquid component of the solution.
SUBSTANCE: invention relates to nanotechnologies, particularly, to the methods of producing ordered nanostructures on the surface and inside high bandgap semiconductors and dielectrics in highly dissipative nonlinear dynamic systems. The proposed method consists in concentration of linearly polarised ultra-fast laser radiation at the area of processing a specimen through its polished surface, selection of laser radiation power density proceeding from the condition of exceeding the critical concentration of non-equilibrium electrons (n) in the conductance band. Note here that the critical concentration of non-equilibrium electrons and laser radiation pulse duration are defined by using certain ratios.
EFFECT: simple and reliable production of reproducible nanostructures.
SUBSTANCE: method consists in mixing aluminium and metal oxides powders in stoichiometric quantities and in carrying out aluminothermic reaction of interaction of said powders. As aluminium powder stabilised nano-dispersed aluminium powder with dimension of particles from 3 nm to 100 nm is used. As metal oxides powder nano-dispersed powders of metal oxides with dimensions of particles from 5 nm to 100 nm are used. Aluminothermic reaction is carried out at presence of initiator in the capacity of which stabilised nano-dispersed magnesium powder is used at the following ratio of components: (aluminium+metal oxide)/Mg=10/(1-10).
EFFECT: acceleration of aluminothermic reaction; elimination of phase disintegration in composite material.
2 cl, 3 tbl
SUBSTANCE: proposed plasma chemical method of producing chromia-alumina catalyst for dehydrogenation of hydrocarbons involves thermal processing of initial reagents, taken in form of aluminium and chrome carbonyl powder in a stream of an air low-temperature plasma. The reagents are put into the stream of the air plasma and reactor separately, in form of an aerosol with argon carrier gas in quantity, sufficient for obtaining a catalyst, containing 15-20 wt % chrome oxide and 80-85 wt % aluminium oxide, which is cooled to temperature not above 40°C in form of a pulverised stream, and extracted from the reactor. The catalyst powder undergoes oxidative processing by at least one chemical reagent, chosen from a group comprising nitric acid, ammonium nitrate, ammonium dichromate, taken in form of an aqueous concentrated solution. Excess reagent is evaporated. The processed catalyst is dried and baked in air at temperature not higher than 550°C for not more than two hours. The catalyst is processed by the given reagents at 80-100°C temperature for not more than 2 hours. Processing of the catalyst in nitric acid is carried out in an autoclave at 175°C temperature for 20 minutes.
EFFECT: increased output of the method, output of target product, its dispersiveness, retention of catalytic activity.
3 cl, 1 dwg
SUBSTANCE: invention can be used in devices or materials for light generation, printing or marking. Luminescent nanoparticles include nucleus, obtained from luminescent metal salt, selectedfrom phosphates, sulphates or fluorides, which is surrounded by envelope, obtained from salt or metal oxide, which can prevent or reduce transfer of energy from nucleus after its electronic excitation to surface of nanoparticle. In order to obtain luminescent nanoparticles, according to invention first mixture, which contains nanoparticles of optionally alloyed luminescent sulphate, phosphate or fluoride of metal in organic medium is obtained. After that obtained mixture is subjected to interaction with source of anions for formed envelope and second mixture, which contains envelope-forming metal ions and organic complex-former, at 50-350 °C.
EFFECT: quantum output increase.
22 cl, 2 dwg, 4 ex
SUBSTANCE: present invention can be used in construction materials when making block and monolithic concrete. The composition contains cement, sand, water and carbon-bearing nano-material - soot, obtained using an electroarc method, and containing 7% of carbon nanotubes, with the following ratios of components, in wt %: cement 20-30, sand 50-70, carbon-bearing nano-material 1-2, water constitutes the rest.
EFFECT: increased compression strength of the construction material.
1 ex, 2 dwg
SUBSTANCE: antiseptic polymer material is used for producing computers and related components, housings of refrigerators and other household appliances incorporating polymer details and/or the cases, panels for cars instrumentation, as well as medical instruments subjected to dissemination by microorganisms in their use. The proposed antiseptic material includes metal nanoparticles containing silver. Note here that the nanoparticle size does not exceed 0.1 mcm, while the content of silver in these particles makes from 80% to 99.999%, that of iron varies from 0.001 to 20%, the content of aluminium varies from 0.001 to 20% and the content of copper varies from 0.001 to 20%. The aforesaid polymer material can be made from the polymers selected from the following group, i.e. polyhydrocarbons, polyethers, polyacrylates, polyvinyl chlorides, polyamides, and can additionally contain a dye, to produce various packages, disposable utensils, e.g. cups, plates, spoons, plugs, etc.; car details etc.
EFFECT: production of antiseptic polymer material.
8 cl, 1 dwg
SUBSTANCE: invention relates to the method for obtaining nanoparticles with a diameter of less than 30 nanometers, containing metal vanadate (III). The method includes reaction of reactive vanadate source in reactionary medium, soluble or dispersible in reactionary medium, and reactive salts of metal (III), soluble or dispersible in reactionary medium at warming. The reactionary medium contains water and, at least, one polyol at volumetric ratio from 20/80 to 90/10. The above polyol represents an organic bond having two, three or more hydroxylic groups, admixed with water in the used volumetric ratio and at the used reaction temperature. Nanoparticles containing metal vanadate (III) represent unessentially doped nanoparticles of metal vanadate (III). Dopped nanoparticles are characterised by excellent luminescent properties.
EFFECT: production of nanoparticles containing metal vanadate (III) with a high yield and narrow particle distribution by sizes.
22 cl, 6 ex
SUBSTANCE: invention relates to nanotechnologies and can be used at production of solidphase nanostructurised materials, in particular, ultradisperse diamonds, fullerenes and carbon nanotubes. The mixture with the negative oxygen balance, consisting of carbon-bearing substances and oxidiser is prepared. Acetylene or kerosene are used as carbon-bearing substances. The mixture containing acetylene is injected into the detonation chamber made in the form of semi-closed resonant chamber 2, in the following manner: that with the excess oxidiser factor of less than 0.14 is injected through porous face wall 5, and that with the excess oxidiser factor of more than 0.96 - through the annular supersonic nozzle 4. The mixture containing kerosene is injected into chamber 2 in the following way: that with the excess oxidiser factor of less than 0.12 is warmed up at pressure of 0.2-25 MPA up to 640-860°C and is injected through porous face wall 5, and that with the excess oxidiser factor of more than 0.9 is warmed up at the pressure of 0.6 MPA up to 640-860°C and is injected through annular supersonic nozzle 4. In chamber 2, by means of initiator 3, the mixture detonation is made. The process is carried out periodically in quasi-stationary regimen at frequency of 100-20,000 Hz at the rate of detonation products cooling of 2·105-106 K/s. Labouriousness of the process is decreased, the mass and dimensions of the device are reduced and quality is improved due to depression of impurities in detonation products at their fast emission into vacuum or inert medium.
EFFECT: decreased labouriousness of the process, smaller mass and dimensions of the device, improved quality.
3 cl, 1 dwg
SUBSTANCE: invention refers to production of modified extender for nanocomposite, and to polyolefin nanocomposite, and can be used for production of materials with preset performance. Production of modified extender includes as follows. Natural layered silicate is processed in aqueous suspension with modifying additive in amount equal to 25-75% of cation-exchange capacity of natural layered silicate. Herewith modifying additive is dioctadecyldimethylammonium bromide added to suspension as aqueous solution concentrated no more than 8.5×10-3 mol/l at 60-80°C. Prepared suspension is cured. Extended is dewatered, washed with distilled water and dried. Trace modified extender added to polyolefin allows for considerably increased durability of produced composite material nanocomposite, including due to conservation of linear dimensions of initial natural layered material.
EFFECT: increased durability of produced composite material.
3 cl, 1 tbl, 5 ex
SUBSTANCE: invention refers to production of modified nanocomposite and polyolefin nanocomposite extender and can be used for materials with desired performance. Modified extender is produced by processing of natural layered silicate in aqueous suspension with two modifying additives added in turn at 60-80°C as prepared aqueous solution with concentration of 0.005-0.010 mol/l. At first aqueous suspension is added with cetyltrimethylammoniumbromide in amount equal to 25-50% of cation-exchange capacity of natural layered silicate, and when cured, added with dioctadecyldimethylammoniumbromide in amount equal to 25-75% of cation-exchange capacity of natural layered silicate. Produced suspension is cured. Extender is dewatered, washed with distilled water and dried. Trace modified extender added to polyolefin allows for considerable increase of produced composite material nanocomposite, including due to conservation of linear dimensions of initial natural layered material.
EFFECT: higher durability of produced composite material.
3 cl, 1 tbl, 5 ex
SUBSTANCE: device has metal, non-metal or ceramic body coated with active ingredients set usable for producing bones or has the ingredient set as a component. The active ingredients set has at least one structural ingredient based on extracellular substance, at least one ingredient for promoting cell migration, at least one ingredient as adhesive agent and at least one ingredient for supporting growth or maturation. Hollow metal body is shaped as cylinder of lattice structure and preferentially manufactured from titanium or titanium alloy.
EFFECT: high mechanical stability when preserving high active ingredient effectiveness; no adverse immune side responses.
5 cl, 9 dwg, 2 tbl
FIELD: medical engineering.
SUBSTANCE: device has a set of active ingredients. At least one structural ingredient based on extracellular substance, minimum one ingredient providing cell migration, minimum one adhesive ingredient, minimum one ingredient providing growth or maturation are used for producing the implantable prosthesis. External endoprosthesis surface is minimum partially coated with a set of active ingredients. The endoprosthesis has also minimum one internal cavity filled with a set of active ingredients.
EFFECT: long service life; accelerated engraftment in organism; greater load applied at earlier stage.
4 cl, 4 dwg, 2 tbl
FIELD: medicine; maxillofacial surgery.
SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М" and polyamide film 12/10. The novelty consists in additional introduction of titanium powder; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, titanium powder 2.5-7.5, polyamide film 12/10 the rest. Titanium powder particles size is 20 to 50 mcm.
EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering.
2 cl, 1 tbl
FIELD: medicine; maxillofacial surgery.
SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М"and polyamide film 12/10. Silver powder is additionally introduced; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, silver powder 2.5-7.5, polyamide film 12/10 the rest. Silver powder particles size is 20 to 50 mcm.
EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering, gaining anti-inflammatory and antiseptic properties.
2 cl, 1 tbl, 3 ex
SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered titanium and silicon at following ratio of components, wt %: carbon-base material "ТГН"-2M 60-64.5, powdered titanium 1.25-3.75, powdered silicon 1.25-3.75, and polyamide film 12/10 - the rest. Particle size of powdered silicon and titanium is 20-50 mcm.
EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.
3 cl, 1 tbl, 3 ex
SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered silicon at following ratio of components wt %: carbon-base material "ТГН"-2M 57.5-62.5, powdered silicon 2.5-7.5, and polyamide film 12/10 - the rest. Particle size of powdered silicon is 20-50 mcm.
EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.
2 cl, 1 tbl, 3 ex
FIELD: medical engineering.
SUBSTANCE: method involves precipitating pyrocarbon layer on graphite substrate surface by carrying out carbonaceous gas from gas flow in flow reactor, separating pyrocarbon layer from the substrate and mechanically manufacturing cusp with paired supporting projections. Constant graphite substrate orientation is provided with relative to gas flow direction in the reactor during the whole pyrocarbon layer sedimentation process. The paired supporting projections are arranged in a way that their imaginary axis remains coinciding with carbonaceous gas flow direction when precipitating pyrocarbon layer. Graphite substrates are mainly shaped as plates placed into flow reactor along its lateral walls without spaces available between them. Six and more plates are placed into the reactor. The most convenient carbon compound for producing pyrocarbon by decomposition is methane. Propane and trichloroboron availability in gas flow is desirable. Additional inert carrier gas like nitrogen is available in the gas flow in addition to active ingredients. Pyrocarbon sedimentation and its final characteristics are controlled by varying nitrogen and active substances proportion in the gas flow.
EFFECT: high reliability of design.
3 cl, 2 dwg
SUBSTANCE: invention relates to composition materials used in making endoprosthesis and in using the composition material for replacement of osseous tissue. The composition material for replacement of osseous tissue comprises a porous matrix made of carbon fiber and carbon material - a filling agent filling pores of matrix partially and wherein the interplanar distance d002 in carbon material crystal is 3.58-3.62 Å, and the interplanar distance d002 in carbon crystal-a filling agent is 3.42-3.44 Å in the total amount of carbon fiber 20-80%. Invention provides enhancing strength and safety of junction of endoprosthesis material with osseous tissue due to creature of the composition material for replacement of osseous tissue with the elasticity modulus equal with the human and animals elasticity modulus in the range 14-28 hPa.
EFFECT: improved and valuable properties of material.