Method of thromboplastin formation normalisation in patients suffering from metabolic syndrome
FIELD: medicine; cardiology and endocrinology.
SUBSTANCE: thromboplastin formation normalisation in patients suffering from metabolic syndrome (MS) is ensured with four-month hypo-calorie diet, graduated static and dynamic physical activity, preparations dosed 30 mg once a day and Lozartan dosed 50 mg once a day.
EFFECT: normalisation of thromboplastin formation activity and time in patients suffering from MS.
The invention relates to medicine, namely to cardiology and endocrinology.
The closest analogue of the proposed method to normalize thromboelastography in patients with metabolic syndrome (MS) is a method of influence on thromboelastography in patients with metabolic syndrome through introduction of lovastatin within 1 month. The source could not even get close to normal levels thromboelastography in patients with metabolic syndrome.
The claimed method differs from the known fact that instead of lovastatin administered pioglitazone 30 mg 1 time per day and losartan 50 mg 1 time per day, and optionally assign a personalised low-calorie diet and rationally dosed static and dynamic exercise.
There is information on the use of a low-calorie diet (Savelyeva L. Modern approaches to treatment of obesity. // The doctor, 2000, No. 12, p.12-14; Kadyrov, BC, Salhanov B.A. Nutrition in obesity. Alma-ATA, Kazakhstan, 1990) or physical training (V. Moshkov. Exercise in obesity. M, "Medicine", 1976, 56 C.) in patients with various components of MILLISECONDS.
In patients with MS for lowering blood pressure are often assigned to losartan. For the correction of insulin resistance in patients with MS is assigned to pioglitazone. However, never before healing comp is CEN, consisting of a low-calorie diet, exercise stress, drugs losartan and pioglitazone, have not been applied in patients with metabolic syndrome to normalize increased their thromboelastography.
The aim of the invention is the normalization thromboelastography in patients with metabolic syndrome.
The essence of the proposed method lies in the fact that for the normalization of thromboelastometry patients with metabolic syndrome in 4 months is assigned to a low-calorie diet, measured static and dynamic exercise, drugs pioglitazone at a dose of 30 mg 1 time per day and losartan 50 mg 1 time per day.
The method allows to normalize thromboelastography in patients with MS for 4 months. Subject to the subsequent recommendations of the proposed method can be maintained at a normal level thromboelastometry that will significantly improve the quality of life of patients with MS, to reduce their pathological burden, reduce the number of cases of temporary disability, to accelerate and improve the quality of patient treatment, to exclude disability, as well as extend the life and reduce mortality of patients with MS from a heart attack and stroke.
The inventive method is carried out as follows.
The formation of endogenous Tambol is Stina is determined by R. Biggs, Douglas A.S., Macparlane R.G. The formation of thromboplastin in human blood. // J. Physiol.1953. - vol.119, No. 1. - p.89-104.
The principle of the method. Activity and the formation of thromboplastin from the component plates, deproclamation plasma and serum analyzed blood thrombin time test plasma in one-minute intervals. During the incubation of this mixture with calcium within 3-6 min is formed of highly active thromboplastin.
To determine endogenous thromboplastin need the following ingredients:
1. suspension of platelets;
2. deproclamation plasma;
4. calcium chloride.
1. 0.1 m solution of sodium oxalate;
2. 1/40 m solution of calcium chloride;
3. 0.15 m suspension of barium sulfate;
4. saline solution.
In silikonizirovannaya tube containing 0.6 ml of 0.1 m solution of sodium oxalate, recruited from Vienna dry point of 5.4 ml of blood. Caution the contents of the tubes are mixed. At the same time in another test tube take 1-2 ml of blood, from which they get the serum.
Preparation of suspension of platelets: oxalate blood into the silicone tube, centrifuged for 5-7 min at 1500 rpm Plasma is sucked off silicone pipette to another silikonizirovannaya or plastic tube. Plasma enriched with platelets, centrifuged for 30 min at 3000 rpm Platelets of oseda the t on the bottom of the tube. The plasma, which contains almost no platelets, sucked off into a separate test tube, and platelets add saline solution, gently mixed and centrifuged again for 30 min at 3000 rpm. in minutes, the saline solution is sucked off and the procedure of washing platelets again. After twice washing of platelets to the precipitate add them saline solution, by volume equal to 1/3 the amount of oxalate plasma collected for centrifugation. The contents are well mixed, obtaining a working suspension of platelets.
Preparation of the solution deproclamation plasma: 0.5-1 ml of plasma containing platelets, which was collected after centrifugation for 30 minutes at 3000 rpm, deplorability suspension of barium sulfate, as described above. Deproclamation plasma diluted with saline solution in a ratio of 1:4.
Preparation of serum diluent: 1-2 ml of venous blood collected in a dry test tube, placed into a water bath at 37°With 2 hours. Serum separated from the clot by centrifugation and diluted with physiological solution at a ratio of 1:8.
Method of test: the number of the agglutination test tubes (7-8) in a water bath at 37°contribute to 0.1 ml of plasma containing platelets, which remained after centrifugation within 30 minutes at 3000 rpm (part of this plasma is taken to gepatrombin). Separately in an empty test tube, also on a water bath, pour 0.3 ml of a suspension of platelets, 0.3 ml of a solution deproclamation plasma of 0.3 ml serum 0.3 ml 1/40 m solution of calcium chloride and include a stopwatch. Every minute 0.1 ml of this mixture and 0.1 ml 1/40 m solution of calcium chloride at the same time make one of a series of tubes containing plasma without platelets and include another stopwatch. Shaking the tube, mark the clotting time of plasma. Minutely study continue to until thrombin time, plasma will not be as short as possible. It prothrombin time characterizes the activity of thromboplastin, and the moment at which curled mixture is the time of the formation of thromboplastin. Normal thromboplastin is formed on the 2-4 minute, and its activity is equal to 12-14 seconds.
When you register accelerate education and/or enhancing the activity of thromboplastin patients with MS is assigned to the proposed medical complex. To create a negative energy balance in the body, patients are advised individually selected low-calorie diet.
Calorie daily diet individually for each patient with MS is calculated in kcal by the formula:
for women 18-30 years (0,0621 × body mass, kg + 2,0357) × 240,
31 - 60 years (0,0342 × mA the sa body, kg + 3,5377) × 240,
over 60 years of age (0,0377 × body mass, kg + 2,7545) × 240,
for men 18-30 years (0,0630 × body mass, kg + 2,8957) × 240,
31 - 60 years (0,0484 × body mass, kg + 3,6534)× 240,
over 60 years of age (0,0491 × body mass, kg + 2,4587) × 240.
The resulting coefficient remains unchanged with minimal physical activity, multiplied by 1.3 in moderate and 1.5 - high physical activity (usually in patients with MS, the level of physical activity low).
It is recommended that 3 main meals and 2 intermediate. With regular skipping one meal significantly increases the incidence of obesity, also revealed a positive correlation between obesity and skipping Breakfast. It is recommended that the following distribution of daily calories: Breakfast - 25%, 2nd Breakfast - 10%, lunch - 35%, tea - 10%, dinner - 20%.
To compile menu the patient uses a special table with the instructions of the chemical composition and caloric content of products, given that the main sources of energy: protein (1 g contains 4 kcal), fat (9 kcal), carbohydrates (4 kcal) and alcohol (7 kcal).
The second component of the proposed method is feasible regular physical exercise.
In real life you can implement the three forms of physical activity: 1) morning hygienic gymnastics (charging);2) health care gymnastics; 3) fractional exercise during the day.
1. Morning hygienic gymnastics (charging)
Morning gymnastics should do after waking up to Breakfast in a ventilated room. Under the influence of training the body is released from the state of inhibition of the physiological processes taking place during sleep.
The sequence of the exercises involves the alternation of load on different muscle groups (arms, legs, body). Exercises are performed with gradually increasing excursion breathing, stretching, limited use of power conditions. Breathing exercise should be free, rhythmic, without delay, mainly through the nose; the exhalation should be longer than the inhale (breath in 2-3 sec, exhale 3-5).
In good health the load, you can increase the number of repetitions faster, increase range of motion and shorter pauses between exercises.
When fatigue should reduce the load, increase the duration of pauses between exercises, to fill their quiet breathing.
After gymnastics, you must go to the rubbing or take a shower.
Morning exercises should evoke a sense of vitality, increase activity, improve well-being and health.
If you feel unwell, develop shortness of breath or pain in the area with whom rDNA and the sternum should be temporarily suspend classes and consult a doctor.
During the day, patients with MS recommended treatment and preventive exercises. Depending on the initial fitness may apply at the beginning of the lightweight option, physical activity, and subsequently enhanced option.
2. Complexes of preventive and curative gymnastics for people with MS
2.1. The lightweight version of preventive and curative gymnastics.
Exercise 1. Standing. A quiet walk with a gradual acceleration and deceleration 1-2 minutes on the exercise of the gradual deepening of the breath.
Exercise 2. Circular motion in the shoulder joints. When breeding - breath, when the note - exhale with a slight tilt of the torso and retraction of the abdominal wall 6-8 times. The fingers touch the shoulders, elbows close to the torso.
Exercise 3. Standing, hands on his belt. Alternately shifting the weight of the body from one foot to the other with a small bending the legs at the knee joint without lifting the feet from the floor. Exercise done 10-16 times with the muscles of the legs.
Exercise 4. Standing, feet apart at shoulder width, hands on his belt. Bending the trunk forward, touch right hand to left toe. 4-6 times alternately. When straightened position - breath, when the tilt - exhale. To look ahead.
Exercise 5. Standing with arms along the body. At the same time to take straight arm and one leg to the side with alternating lead nogyo 4-6 times in each direction in turn. A wave of the hands and feet, breathe freely, do not delay.
Exercise 6. Standing, feet apart, hands in front of chest with palms down. With a turn of the body to dissolve hand in hand with turning the palms up - breath. To return to the original position with a small tilting forward, exhale. 3-5 times in each direction in turn. Breathing to harmonize with the movement of hands and body. By the end of exhalation to engage the wall of the abdomen.
Exercise 7. Standing, hands free. The walk free - 1 min, then with high flexion of the hips - 10-20 movements with subsequent transition to a peaceful walk 1-2 minutes Breathing rhythmic, medium depth.
Exercise 8. Sitting on the edge of the chair, hands on the waist. The bowing of the back and bending forward of the body. Repeat 6-10 times. Breathing is not to delay.
Exercise 9. Sitting on the edge of the chair, the emphasis tassels on the edge of a chair, and your feet slightly in front of the chair. Squats with a focus hands on the edge of a chair - 4-6 times. When you squat exhale.
Exercise 10. Standing sideways to the back of the chair to hold it with one hand. Swing free straight arm with leg pulling back. To return to the original position. Repeat 4-6 times for each leg and arm. Breathing is not to delay.
Exercise 11. Standing, legs apart widely, hands on waist. Turns the body right and left - 6-10 times alternately. The head does not turn, to look forward.
Exercise 12. Standing, feet instead of the e, hands down. Move the hands to the sides, inhale, bend the leg at the knee and pressed his hands to his stomach exhale. 3-5 times each leg alternately. Strive to maintain balance; on the exhale, draw your abdomen.
Exercise 13. Standing, feet together, hands down. The side slopes of the case with flexion of the opposite hand ("pump"). Breathing is not to delay, to strive for greater excursion of movement.
Exercise 14. Standing. The walk is quiet with a steady breath average depth of 1-2 minutes
Exercise 15. Lying on the Mat to put under your head with a pillow. Go to a half-sitting position and bent to hug the hips, exhale, return to the starting position and inhale. Breath hold. Strive in a semi-sitting position to maintain balance. Run 4-6 times.
Exercise 16. Lying down, arms at sides, legs apart. A semi-circular motion right straight leg to the left with the rotation of the pelvis - exhale - return to the starting position and inhale. 3-5 times in each direction. Alternately left and right, with the greatest possible excursion movement of the leg, keeping the emphasis brushes the floor.
Exercise 17. Sitting on the floor; a) to stand on all fours; b) to move into position on his knees; hands up - breath, torso, and hands to take back - exhale. When the tilt pull the stomach. Repeat 4-6 times; d) to go into a standing position, and then in the supine position; (e) self-massage W is the Voth small polukrugom movements clockwise-1-2 minutes Rest 2 min; W) quiet breathing; C) exercise the protrusion (calm) and retraction (active) abdominal wall. The retraction of the abdomen combined with exhale through the mouth. Repeat 4-6 times.
Exercise 18. Standing with arms bent. Energetic walking on the spot or area of high flexion of the hips and waving of hands - 20-30 steps. Breathing is not to delay.
Exercise 19. Sitting on a chair, legs apart, hands on the waist or rest against the edge of a chair. The circular motion of the pelvis with the retraction of the abdomen when moving the pelvis back. 4-6 times in each direction.
Exercise 20. Standing. A peaceful walk with the breath of the average depth of 2-3 minutes
When the source sufficient trained or arising in the course of the practice of tolerance to physical loads you can use the following set of exercises.
2.2. Enhanced preventive and curative gymnastics
Exercise 1. Standing. The quiet walk with rubbing the palms of the thorax, abdomen, lower back. Runs 1-2 minutes
Exercise 2. Standing, hands down. Simultaneous bending with tension and free "throwing" hand forward, sideways and upwards of 12-16 times. When you bend exhale, when the alignment of breath.
Exercise 3. Standing, hands on waist, legs shoulder-width apart. Lateral motion of the pelvis to the right and left, back and forth. Is 6-10 times alternately. Breathe freely.
Control the imposition of the 4. Standing, feet shoulder-width apart, hands down. Circular motion direct hand in the shoulder joints, 6-10 times with a maximum excursion, breathing, do not delay.
Exercise 5. Standing, hands in front of chest, bent at the elbows. Walking with high flexion of the hips, with a touch of the hand. 6 -10 times for each leg alternately. Motion of energetic, hip flexion - exhale through the mouth.
Exercise 6. The quiet walk 1-2 minutes
Exercise 7. Sitting on the edge of the chair, hands on the waist. Bending and bowing of the body. The exercise is performed 8-10 times. The energetic movement. When straightening - breath, bending exhale.
Exercise 8. Standing sideways to the chair, to hold back, the other hand on the waist. Alternate sweeps straight leg forward, with the greatest possible tour. Swing legs to be combined with the exhalation. Runs 4-6 times.
Exercise 9. Standing, feet apart, hands at sides. Bending the body forward, touch right brush left toe of the feet, the other hand is allotted up. To return to the original position. Tilt combined with exhalation, by straightening the breath, by 4-6 times.
Exercise 10. Walking the quiet breathing of medium depth. 1-2 minutes
Exercise 11. Standing, hands in a fist and lowered: (a) bending of the arms at the elbows with the power and extension of their diverting ago, with possibly large rectification and voltage and delay in the stress state within 2-3 C. one Hundred is, hands on waist; b) proprietary with subsequent lifting in socks and tension legs. The exercise is performed 4-6 times with possibly large rectification and voltage and delay in the stress state within 2-3 C.
Exercise 12. Sitting on the edge of the chair. In the raised position and bent knee leg to make alternate shaking the hands of the calf muscles and thighs. To reduce muscle tension. 1-2 minutes
Exercise 13. Sitting on the edge of the chair, straight leg divorced. Pinch open and direct the hands and feet. When breeding breath, when the note - exhale. Is 4-8 times.
Exercise 14. Standing. The quiet walk with the transition to the rhythmic quiet running (Jogging) on the spot or moving. For fatigue to go on a peaceful walk with the breath of medium depth. 2-5 minutes
Exercise 15. Lying on the Mat. Simultaneous lifting of the body and legs on the exhale. 4-6 times. Arms and legs should be straight, to keep the balance.
Exercise 16. Lying on the Mat, the emphasis brushes the floor. Cross movement straight leg - scissors. 4-8 times. Breathing is not to delay.
Exercise 17. With a quick straightening of the legs to move into a sitting position, then to lie down. You can help stroke 4-6 times.
Exercise 18. Lying on your back, legs bent. Calm breathing 4-6 times.
Exercise 19. Lying on his back, hands diluted with emphasis brushes the floor. With the rotation t is for the left, to bend the legs, rotate the pelvis with legs crossed to the right and stretch the legs. To repeat such a circular motion feet 3-6 times in each direction alternately. Hands not off the floor. Breathing is not to delay.
Exercise 20. Lying on your back, arms and legs separated. Alternate turns the body right and left laying one hand to the other. Feet are not slipping. When divorced hands - breath, turning exhale. Performed 3-6 times.
Exercise 21. Lying on your back, arms along the body: a) turn on your left side; b) to turn on the right side; C) switch to lying on his stomach; to kneel; d) to move in a standing position; (e) walking on the spot with high flexion of the hips and the movement of the hand - 20-30 steps; g) to sit on the Mat; C) lie on your back, relaxing breath. The whole complex repeat 3-4 times.
Exercise 22. Standing. Walking the quiet breathing of the average depth of 1-2 minutes
Exercise 23. Standing, feet apart on the width of the foot, hands on waist. Circular motion of the pelvis, right and left 6-8 times. Breathing is not to delay.
Exercise 24. Standing with legs wide apart, hands in front of chest. Alternately bending the legs with the transfer to it of gravity of the body with stretching hand to toe of the bent leg. 4-6 times in each direction. The other leg is straight. When straightening - breath, when the tilt - exhale.
Exercise 25. Standing, feet rasstavleniya shoulder width, hands on waist. Circular head movements by 4-10 times in each direction.
Exercise 26. Standing, feet apart at shoulder width, hands on waist. Bend trunk to the right, pulling the left arm up - breath. Return to starting position - exhale. 4-6 times alternately.
Exercise 27. The same hands to the shoulders. Circular motion of the brushes with the maximum excursion in the shoulder joints, when breeding - breath during the mixing and retraction of the abdominal wall exhale. Breathing deep.
Exercise 28. Standing. A peaceful walk and breath the average depth. The reduction of the total load. 1-2 minutes
3. Fractional exercise during the day
The patient with MS is sick with a number of related disorders and primarily the cardiovascular system. This circumstance limits the simultaneous application of a high physical load during morning exercises, as well as in the main lesson, curative gymnastics. This is why increasing the physical activity of individuals with MS should be implemented by the distribution of physical activity in small doses throughout the day. This method of increasing physical activity in patients with MS should be considered as a method of fractional loads.
Depending on the real conditions of life of patients with MS, patients with various degree of abdominal obesity, morerecommendation various exemplary embodiments of the fractional loads to increase physical (motor) activity during the day.
Exercise 1. Sitting - dilute the elbows to the sides, inhale, extend hands forward voltage exhale, 4-6 times.
Exercise 2. Sit - to stand with the deflection of the housing and land - 8-10 times.
Exercise 3. Sitting mimicking the movements of a boxer with possibly a large turn of the body is 10-12 times.
Exercise 1. Standing - walking with high flexion in the hip - 16-30 times.
Exercise 2. Standing - circular head movements to the right and left - 3-8 times in each direction.
Exercise 3. Standing legs apart widely imitated the movements of Costa - 10-12 times.
Exercise 4. Sitting - transition into the standing - 10-12 times.
Exercise 1. The quiet walk - 1 min
Exercise 2. Walking fast - 1 minute
Exercise 3. Walking with high flexion of the hips and alternate wave of the hands 20-30 times.
Exercise 4. Walking the quiet breathing of 1-2 min; quiet running on the spot or move around the room - 2-5 minutes
Walk the pedestrian varying length.
Physical work in different ways and with different duration depending on the conditions (cleaning, home services, cleaning, gardening work, and others).
In addition to custom-made non-medical treatment for patients with MS on the background of stable antihypertensive therapy with losartan 50 mg 1 p is C per day should be administered pioglitazone 30 mg 1 time per day. This complex normalizes thromboelastography for 4 months, which is essential to reducing the overall pathological family history and the key to improving quality and prolongation of life in patients with MS.
Example. The patient M, 59 years old, with body weight 79,0 kg, body mass index 29,2 kg/m2suffering from metabolic syndrome for 9 years, in the morning on an empty stomach was taken blood from the cubital vein and determined the formation and activity of thromboplastin, which amounted to 1.3 min and 10.0 seconds, respectively. The patient was assigned individually selected low-calorie diet (1999,1 kcal.), the system of daily physical activity, pioglitazone 30 mg 1 time a day, losartan 50 mg 1 time a day. The patient was examined every 2 weeks after the start of treatment. Simultaneously with the inspection was carried out the determination of the activity and the time of formation of thromboplastin.
After 4 months of treatment, the patient began to decline body weight (75,0 kg) and body mass index (27.7 kg/m2). Activity and the formation of thromboplastin normalized, accounting for 12 seconds and 2.9 min, respectively. The patient is asked to comply with these recommendations in future.
The use of the proposed method to normalize thromboelastometry cardiology and endocrinology will help to avoid many complications in patients with metabolic syndrome, the mind is nishit have the number of cases of temporary disability, to reduce the duration of hospitalization, reduce morbidity and mortality.
Method normalize thromboelastography in patients with metabolic syndrome, including the appointment of individualized low-calorie diet, rationally dosed static and dynamic physical loads, drugs pioglitazone 30 mg 1 time per day and losartan 50 mg 1 time a day for 4 months.
SUBSTANCE: essence of claimed inventions lies in local extravascular introduction of vasculoproliferative compound of rapamicyn, which is carried out by means of device, placed on outer vessel surface. Device represents implanted cuff containing flexible matrix material in form of cylindrical tube, which has opening, corresponding to vessel size. Matrix material contains dispersed in it antiproliferative agent - rapamicyn, which being gradually released from cuff, locally goes into vessel wall.
EFFECT: efficient reduction or prevention of vascular proliferation and hyperplasia of unstriped muscle cells due to prolonged supply of constant concentration of rapamicyn locally into vessel wall.
36 cl, 12 tbl, 14 ex, 20 dwg
FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutically acceptable salts of sulfonic acid bonding of compound Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-(S)Aze-Pab(OMe), where Aze - azetidin-2-carboxilate, Ph - phenyl, Pab-p-amidinobenzylamino and Me - methyl, which are useful as pro-medication of competitive inhibitors of tripsin-like proteases such as thrombin, and, thus, in particular, in treatment of conditions which require thrombin inhibition (for instance, thrombosis), or as anticoagulants. Invention also relates to method of obtaining such salts.
EFFECT: obtaining pharmaceutically acceptable salts of sulfonic acid bonding.
7 cl, 12 tbl, 20 ex, 5 dwg
FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to novel chemical composition from group quaternary ammonium salts of succinic acid, namely, 1-deoxy-1-N-methyl ammonium-D-glucitole succinate (meglumine succinate) .
EFFECT: obtaining chemical composition which acquires ability to impact on complex of pathological changes accompanying sugar diabetes.
4 cl, 6 tbl
SUBSTANCE: invention refers to new derivatives of hydrochloride 8-amino-7-(2-hydroxypropyl-1)-1,3-dimethylxanthine of general formula: where . Compounds under this invention display haemorheological activity surpassing that of common pentoxifylline compound. Compounds represent hydrochloride 1,3-dimethy-7-(2-hydroxy-3- piperidinopropyl-1)-8-phenylaminoxanthine or hydrochloride 1,3- dimethy-7-[2-hydroxy-3-(2- chlorophenoxy)-propyl-1]-8- piperazinoxanthine.
EFFECT: production of compounds displaying haemorheological activity.
4 cl, 2 tbl, 4 ex
FIELD: medicine; pharmacology.
SUBSTANCE: new medical product possessing hemorheological and antiplatelet properties represents a dry extract preparation of Amur maackia.
EFFECT: arsenal expansion of the antiplatelet vegetative means, improving rheological properties of blood and an antiplatelet effect.
6 ex, 2 tbl
SUBSTANCE: method includes application of individually chosen hypohigh-calorie diet, the dosed out physical activities and introduction of Pyoglitazone 30 mg once a day and Valsartane 80 mg, 1 time at the same time of the day. The combined application of a hypohigh-calorie diet, physical activities and Pyoglitazone and Valsartane preparations in the specified dosages allows normalising activity of protein C within three months at patients with metabolic syndrome.
EFFECT: optimisation of activity of protein C at patients with metabolic syndrome.
1 ex, 1 tbl
SUBSTANCE: method includes application of the hypohigh-calorie diet, the dosed out loads and introduction of Pyoglitazone 30 mg once a day, Irbersartane 150 mg, 1 time in the same time and Lerkanidipine - 10 mg in the morning. The combined application of a diet, physical activities and the given preparations allows normalising fibrinosis level in blood plasma during 3 months.
EFFECT: optimisation of fibrinosis level at metabolic syndrome.
FIELD: medicine; pharmacology.
SUBSTANCE: method consists in polymer hydrogel production, containing physiologically active substances, by physiologically active substance immobilisation in cross-linked polymer volume, modified with ovomucoid from duck egg-white; the cross-linked polymer being additionally modified with α-amylase inhibitor from wheat seed; as physiologically active substance heparin or hirudin is used. The cross-linked polymer modified with ovomucoid and α-amylase inhibitor is obtained by chemical modification of polymer with ovomucoid and α-amylase inhibitor mix, in proportion of 0.5 to 15 mg ovomucoid to 1 g swollen cross-linked polymer, and 0.5 to 5.0 mg α-amylase inhibitor to 1 g swollen cross-linked polymer.
EFFECT: hydrogels have anticoagulant activity, are eligible for peroral administration in prevention and treatment for cardiovascular disorders.
2 cl, 20 ex, 1 tbl
SUBSTANCE: described is novel compound Ph(3-Cl)(5-OCHF2)-(R)CH(OH)C(O)-(S)Aze-Pab(2,6-diF)(OH) of formula: or its pharmaceutically acceptable salt.
EFFECT: using compound as active ingredient for preparation of medicine for treatment of condition, which demands inhibiting of trombone.
12 cl, 7 ex
SUBSTANCE: at first intact body region safely distant from previous injection is detected. Skin site is processed with alcohol and gathered with left hand to form triangular fold with base downwards. The second finger of right hand holds injection needle, the fifth finger of the right hand holds piston with the other fingers of the right hand holding cylinder. Then needle is quickly inserted into base point of formed triangle at the angle 45° between the first and the second fingers of the left hand, 0.5 cm deep. 2% lydocaine hydrochloride in amount 0.1-0.2 ml is injected. Then syringe is disconnected, and mandrin made of heat-conductive material and protruding from needle is inserted into the needle. Protruding part of mandrin is heated up with open flame until whitish ring is shown on skin round the needle. Then mandarin is pulled from the needle which is attached to the second syringe with heparin. Solution is slowly injected, and the needle is quickly pulled out. After that injection point is wiped with alcohol and pressed with sterile cottonwool tampon for short time.
EFFECT: allows for higher safety of plural heparin injections.
FIELD: medicine; haematology.
SUBSTANCE: patient suffering from MS is prescribed with three-month individual hypo-calorie diet, graduated physical activity and preparations Pioglitazone dosed 30 mg once a day and Valsartan dosed 80 mg once a day. Combinatie application of all complex components allows for normalised plasminogen activator inhibitor level disorders in patients suffering from metabolic syndrome and for ensured functioning level specific for healthy people within three-month treatment.
EFFECT: higher efficiency of plasminogen activator inhibitor level correction in patients suffering from metabolic syndrome.
1 tbl, 1 ex
SUBSTANCE: quick endotheliocytemia normalisation in patients suffering from metabolic syndrome (MS) is ensured with continuous hypocalorie diet, graduated physical activity in combination with preparations Pioglitazone and Valsartane.
EFFECT: endotheliocytemia normalisation in patients suffering from metabolic syndrome and ensured level specific for healthy people within three months of treatment.
SUBSTANCE: correction of lipid composition of thrombocyte membranes in patients suffering from metabolic syndrome (MS) is enabled with three-month individually prescribed hypo-calorie diet, graduated physical activity and preparations Pioglitazone dosed 30 mg once a day, Irbesartan dosed 150 mg once a day and Lerkanidipine dosed 10 mg in the morning.
EFFECT: normalisation of lipid composition of thrombocyte membranes in patients suffering from metabolic syndrome and ensured functioning level specific for healthy people resulted from three-month treatment.
SUBSTANCE: hyperfibrinogenemia correction in patients suffering from metabolic syndrome (MS) is ensured with individually prescribed hypocalorie diet, graduated physical activity in combination with preparations Pioglitazone and Valsartane within 3 months.
EFFECT: normalised hyperfibrinogenemia in MS patients within three months of treatment and ensured fibrinogen blood plasma level specific for healthy people.
FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to novel compounds N(1,3-tiazol-2-yl)amides of 2-diphenylmethylenehydrazono-5,5-dimethyl-2,4-diooxohexane acid of formula (Ia, b): demonstration anti-inflammatory and analgetic activity. Invention also relates to method of their obtaining.
EFFECT: obtaining novel compounds.
2 cl, 1 tbl, 2 ex
FIELD: chemistry, pharmaceutics.
SUBSTANCE: invention relates to compounds of formula 1 and their pharmaceutically acceptable salts as inhibitors of post-proline aminopepdidases, as well as to pharmaceutical composition based on them and application for manufacturing such composition, and to method of inhibition with their application. Compounds can be applied for treatment of diseases mediated by activity of post-proline aminopeptidases, such as type II diabetes and disturbed tolerance to glucose. In general formula 1 ,
either G1 represents -CH2-X2-(CH2)a-G3, and G2 represents H, or G2 represents -CH2-(CH2)a-G3, and G1 represents H; G3 is selected from group according to general formula 2 ,
group according to general formula 3
and group according to general formula 4 ;
a is 0, 1 or 2; b is 1 or 2; X1 is selected from CH2, S, CF2, CHF and O; X2 is selected from CH2; X3, X4 and X5 are selected from N; X6 is selected from NH; X7 is selected from NH; R1 is selected from H and CN; R2 represents H; R3 is selected from H, Cl, OH, NH2, NH-C1-C10alkyl and N(C1-C10alkyl)2; R4, R5, R6, R7 and R8 are independently selected from H, Br, Cl, F, OH, NO2; R9 represents H; R10, R11, R12, R13 and R14 are independently selected from H, Cl and CF3; R15 and R16 are independently selected from H, C1-C10alkyl, C1-C10alkenyl, C3-C10cycloalkyl, C3-C10cycloalkenyl, quinoline, naphtyl and -CH2-L-R17; R17 is selected from C1-C10alkyl, phenyl, naphtyl, quinolinyl and indolyl; L is selected from covalent bond, CH=CH and -C6H4-; on condition that when R15 and R16 both represent H, and b is 1, then X1 does not represent S or CH2.
EFFECT: obtaining compounds that can be applied for treatment of diseases mediated by activity of post-proline aminopeptidases, such as type II diabetes and disturbed tolerance to glucose.
58 cl, 10 tbl, 1705 ex
SUBSTANCE: invention is applied for α2-antiplasmin (α2-AP) level normalisation for metabolic syndrome (MS) patients. Method involves long-term individual hypocaloric diet, rated physical exercise and administration of medicine - 30 mg of pioglitasone once per day and 80 mg of valsartan 1 time at one and the same day time - for α2-AP level normalization for MS patients.
EFFECT: α2-AP level disorder normalisation for MS patients in three months time to a level of healthy people.
1 tbl, 3 ex
SUBSTANCE: method is implemented as follows: for 4 months medical complex consisting of low-calorie diet, graduated exercises, Lercarnidipine 10 mg once a day, Lyoglitason 30 mg once a day, Irbesartan 150 mg once at the same time of day are prescribed.
EFFECT: choice of certain preparations from the specified pharmacological groups in combination with non-drug treatment allows for corrected weakening of vascular wall functions in patients with suffering from MS due to normalisation of antithrombotic activity of vessels within four months of treatment.
1 ex, 1 dwg, 1 tbl
SUBSTANCE: in novel compounds of formula I R1 represents phenyl, possibly substituted with phenyl or heterocyclic group, or heterocyclic group, possibly substituted with phenyl, where said heterocyclic group represents mono- or bicyclic ring, containing 4-12 atoms, of which at least one atom is selected from nitrogen, sulfur or oxygen, each phenyl or heterocyclic group possibly being substituted with one or more than one of the following groups: C1-6alkyl group; phenylC1-6alkyl, alkyl, phenyl or alkylphenyl group is possibly substituted with one or more than one from Rb; halogen; -ORa; -OSO2Rd; -SO2Rd; -SORd; -SO2ORa; where Ra represents H, C1-6alkyl group, phenyl or phenylC1-6alkyl group; where R represents halogeno, -OH, -OC1-4alkyl, Ophenyl, -OC1-4alkylphenyl, and Rd represents C1-4alkyl; group -(CH2)m-T-(CH2)n-U-(CH2)p- is bound either in third, or in fourth position in phenyl ring, as shown with figures in formula I, and represents group selected from one or more than one of the following: O(CH2)2, O(CH2)3, NC(O)NR4(CH2)2, CH2S(O2)NR5(CH2)2, CH2N(R6)C(O)CH2, (CH2)2N(R6)C(O)(CH2)2, C(O)NR7CH2, C(O)NR7(CH2)2 and CH2N(R6)C(O)CH2O; V represents O, NR8 or single bond; q represents 1, 2 or 3; W represents O, S or single bond; R2 represents halogeno or C1-4alkoxyl group; r represents 0, 1, 2 or 3; s represents 0; and R6 independently represent H or C1-10alkyl group; R4, R5, R7 and R8 represent hydrogen atom; and to their pharmaceutically acceptable salts.
EFFECT: increase of composition efficiency.
12 cl, 31 ex
SUBSTANCE: invention relates to medicine, particularly to cardiology and angiology; it can be applied for angiopathy correction in metabolic syndrome patients. The method consists in four-month course administration that includes low-calorie diet, graduated exercise, and drug therapy: 30 mg pioglitazon daily, 50 mg lozartan daily at appointed time.
EFFECT: allows correction of angiopathy manifestations in metabolic syndrome patients, owing to anti-thrombosis activity of blood vessels.
1 ex, 1 tbl, 1 dwg
SUBSTANCE: normalisation of nitrogen oxide level development in vessels of patients suffering from arterial hypertension (AH) associated with metabolic syndrome (MS) and monitored decrease in nitrogen oxide level (normal values for nitrates 5.9-7.1 mmol/l, nitrites 9.2-23.0 mmol/l) is ensured with prescribed medical complex consisting of hypo-calorie diet, graduated static and dynamic physical activity, preparation Telmisartan dosed 80 mg once a day in the morning within 2 months.
EFFECT: normalised development of nitrogen oxide due to activation of its synthesis in vascular wall in MS patients suffering from AH within two-month treatment, with ensured level specific for healthy people.