Medicine for treatment of fish infection diseases of bacterial etiology and treatment method fish infection diseases of bacterial etiology

FIELD: medicine; veterinary.

SUBSTANCE: medicine includes metal iodine and potassium iodide, prolongator and water. 1,2-propylene glycol is used as prolongator, and additionally vitamin A (retinol acetate), vitamin E (alpha-tocopherol acetate), vitamin B1 (thiamine hydrochloride), vitamin B2 (riboflavin), vitamin B6 (pyridoxine hydrochloride), vitamin B12 (cyanocobalamin), iron carbonate, magnium phosphate, manganese sulfate, copper sulfate, zinc sulfate, cobalt chloride, sodium chloride, amber acid, glucose, rectified ethyl alcohol (96%) are applied. Medicine components are taken at the following rate, g/100 ml of distilled water: metal iodine, chemically pure 0.112-0.187; potassium iodide, R 0.337-0.562; vitamin E (alpha-tocopherol acetate) 0.060-0.100; vitamin A (retinol acetate) 3.750-6.250 thousand mass units; vitamin B1 (thiamine hydrochloride) 0.052-0.087; vitamin B2 (riboflavin) 0.037-0.062; vitamin B6 (pyridoxine hydrochloride) 0.034-0.056; vitamin B12 (cyanocobalamin) 0.026-0.044; iron carbonate, R 0.337-0.562; magnium phosphate, R 0.337-0.562; manganese sulfate, R 0.172-0.287; copper sulfate, R 0.090-0.150; zinc sulfate, R 0.315-0.525; cobalt chloride, R 0.071-0.119; sodium chloride, R 0.589-0.981; amber acid, primary standard 0.225-0.375; glucose, AR 0.172-0.287; rectified ethyl alcohol (96%) 0.300-0.500 ml; 1,2- propylene glycol 0.900-1.500 ml. Method involves medicine administration with fodder in dosage of 1.00-1.50 mg per 1 kg of fish weight once per day for 5-7 days.

EFFECT: correction of needs for bioactive substances, prevention of avitaminosis, achievement of high antioxidant organism protection level, prevention of accumulation of non-saturated fatty acid peroxides harmful to fish.

2 cl, 3 tbl, 3 ex

 

The present invention relates to the field of veterinary Microbiology and ichthyopathology, in particular to a drug for the treatment of infectious diseases carp fish bacterial etiology - Aeromonas, Pseudomonas.

The most common infectious diseases of carp fish are Aeromonas and Pseudomonas, which are characterized by the development of a common septic process, dropsy, inflammation of the skin, exophthalmos, erosene scales. Due to intoxication of an organism of the owner of the products of metabolism of pathogenic microflora occurring lipid, protein, enzyme and electrolyte exchanges, as well as a deep pathological changes in the organs of fish.

Currently, for the treatment of bacterial diseases of fish used organic dyes (methylene blue), in the form of baths in breeding from 50-200 mg/l exposure 12-2 PM in the medical form feed at a dose of 2-5 mg/kg of body weight of fish, antibiotics (chloramphenicol, tetracycline) in feed at a ratio of 1:2000 for 3 days, and nitrofuranovye drugs (furazolidone) of 6 g/10 kg of feed for 10 days [1].

To increase natural resistance to appoint a full diet enriched with vitamins and trace elements [2].

Well-known medication for the treatment of Aeromonas and the dog is dominosa Karpov on the basis of iodine from polyvinylidenedifluoride (PUENTE), including:

The hydrosulfate polyvinylidenedifluoride0,80 g
Iodine metal (in terms of active iodine)0.10 g
Potassium iodide0.15 g
Distilled waterto 100 ml

The drug is set with food for 5-7 days at a dose of 0.8-1.2 mg / kg fish biomass [3].

The objective of our research was to obtain the product having a high antibacterial efficacy, bioavailability, and to develop a treatment method, ensure the maintenance and intensification of resistance of the organism of fish.

This was achieved thanks to the fact that the active substance is take the metal and iodine potassium iodide and optionally vitamins a, b, E and minerals in adequate quantities.

A method of treating bacterial diseases of fish, at which the proposed drug is administered with food at doses 1,00-1,50 mg/kg of body weight of the fish once a day, during 5-7 days.

The proposed drug includes, g /100 ml:

Iodine metal, CHP0,112-0,187
Potassium iodide, reagent-gradeof 0.337-0,562
Vitamin E (alpha tocopherol acetate) to 0.060-0,100
Vitamin a (retinol-acetate)3,750-6,250 thousand IU
Vitamin B1(thiamine hydrochloride)0,052-0,087
Vitamin b2(Riboflavin)0,037-0,062
Vitamin b6(pyridoxine hydrochloride)0,034-0,056
Vitamin b12(cyanocobalamin)0,026-0,044
Iron (iron carbonate), reagent-gradeof 0.337-0,562
Magnesium (phosphate), reagent-gradeof 0.337-0,562
Manganese (sulfate), reagent-grade0,172-0,287
Copper (sulfate), reagent-grade0,090-0,150
Zinc (sulfate), reagent-grade0,315-0,525
Cobalt (chloride), reagent-grade0,071-0,119
Sodium (chloride), reagent-grade0,589-0,981
Succinic acid, OFS0,225-0,375
Glucose, analytical grade0,172-0,287
Ethyl alcohol, rectified (96°)0,300-0,500 ml
1,2-propylene glycol0.900 for 1,500 ml
Distilled waterRest

Specific examples of the fabrication are given (g/100 ml):

Example 1
Iodine metal, CHP0,150 g
Potassium iodide, reagent-grade0,450 g
Vitamin E (alpha tocopherol acetate)0,080 g
Vitamin a (retinol-acetate)5,000 thousand IU
Vitamin B1(thiamine hydrochloride)0,070 g
Vitamin b2(Riboflavin)0,050 g
Vitamin b6(pyridoxine hydrochloride)0,045 g
Vitamin B12(cyanocobalamin)0.035 g
Iron (iron carbonate), reagent-grade0,450 g
Magnesium (phosphate), reagent-grade0,450 g
Manganese (sulfate), reagent-grade0,230 g
Copper (sulfate), reagent-grade0,120 g
Zinc (sulfate), reagent-grade0,420 g
Cobalt (chloride), reagent-grade0,095 g
Sodium (chloride), reagent-grade0,785 g
Succinic acid, OFS0,300 g
Glucose, analytical grade0,230 g
Ethyl alcohol, rectified (96°)0,400 ml
1,2-propylene glycol1,200 ml
Distilled waterRest

Example 2
Iodine metal, CHP 0,112 g
Potassium iodide, reagent-gradeof 0.337 g
Vitamin E (alpha tocopherol acetate)to 0.060 g
Vitamin a (retinol-acetate)3,750 thousand IU
Vitamin B1(thiamine hydrochloride)0,052 g
Vitamin b2(Riboflavin)0,037 g
Vitamin b6(pyridoxine hydrochloride)0,034 g
Vitamin B12(cyanocobalamin)0,026 g
Iron (iron carbonate), reagent-gradeof 0.337 g
Magnesium (phosphate), reagent-gradeof 0.337 g
Manganese (sulfate), reagent-grade0.172 g
Copper (sulfate), reagent-grade0,090 g
Zinc (sulfate), reagent-grade0,315 g
Cobalt (chloride), reagent-grade0,071 g
Sodium (chloride), reagent-grade0,589 g
Succinic acid, OFS0,225 g
Glucose, analytical grade0.172 g
Ethyl alcohol, rectified (96°)0,300 ml
1,2-propylene glycolto 0.900 ml
Distilled waterRest

Example 3
Components
Iodine metal, CHP0.187 g
Potassium iodide, reagent-grade0,562 g
Vitamin E (alpha tocopherol acetate)0,100 g
Vitamin a (retinol-acetate)6,250 thousand IU
Vitamin B1(thiamine hydrochloride)0,087 g
Vitamin b2(Riboflavin)0,062 g
Vitamin b6(pyridoxine hydrochloride)0,056 g
Vitamin b12(cyanocobalamin)0,044 g
Iron (iron carbonate), reagent-grade0,562 g
Magnesium (phosphate), reagent-grade0,562 g
Manganese (sulfate), reagent-grade0,287 g
Copper (sulfate), reagent-grade0,150 g
Zinc (sulfate), reagent-grade0,525 g
Cobalt (chloride), reagent-grade0,119 g
Sodium (chloride), reagent-grade0,981 g
Succinic acid, OFS0.375 g
Glucose, analytical grade0,287 g
Ethyl alcohol, rectified (96°)0,500 ml
1,2-propylene glycol1,500 ml
Distilled waterRest

Thus prepared, the drug was tested when Aeromonas is Pseudomonas carp fish in laboratory experiments and in industrial cultivation of fish in the rearing and feeding reservoirs, disadvantaged according to the disease during the outbreak of the epidemic. The method of treatment of infectious diseases of bacterial etiology is as follows: feed set daily, once daily, for seven days, in doses of from 1.00-1.50 mg/kg of body weight of the fish. Specific examples are given in tables 1-3.

Table 1
Species of fishDoseThe multiplicity of feedingResult (% recovery)
PUENTETrial medication
Carp (Cyprinus carpio L.)

Silver crucian carp (Carassius carassius L.)
1,20 mg per 1 kg of biomass of fishSeven days66%89%

Table 2
Species of fishDoseThe multiplicity of feedingResult (% recovery)
PUENTETrial medication
Carp (Cyprinus carpio L.)

Silver crucian carp (Carassius carassius L.)
1.00 mg per 1 kg of fish biomassSeven days73%85%

Table 3
Species of fishDoseThe multiplicity of feedingResult (% recovery)
PUENTETrial medication
Carp (Cyprinus carpio L.)

Silver crucian carp (Carassius carassius L.)
1,50 mg per 1 kg of biomass of fishFive days68%89%

A drug with fewer components iodine metal (less of 1.12 mg/kg fish) and potassium iodide (less 3,37 mg/kg fish) did not provide adequate efficiency of the method of treatment, and excess intake of iodine metal (1,87 mg/kg fish) and potassium iodide (5,62 mg/kg fish) does not give a better result.

The data show that the test drug on the proposed method of treatment is more effective in comparison with PLENTY.

Included in the drug substance as an antibacterial complex - metal and iodine potassium iodide with ethyl alcohol, solvent and prolongator (1,2-propylene glycol), as substances that increase the overall resistance of the body, vitamins, minerals, succinic acid, under appropriate ratios provided the effect of the drug (85-89%) compared to PUENTE (68-73%).

Proposed paragraph shall eparat:

- allows you to adjust the necessary need for biological active substances, excluding the development of avitaminosis and

- creates a high level of antioxidant protection of the body, thus preventing the accumulation of toxic fish peroxides of unsaturated fatty acids.

The proposed remedy has been tested by us with a positive result in 2004-2006 under laboratory conditions (VIEW) and fish farms of the Moscow region, Odintsovo district ("These Islands"), Kolomna district ("Asenka"), troubled by Aeromonas Karpov.

The proposed remedy and treatment method will find application in farms affected with infectious diseases of bacterial etiology, which will eliminate disease outbreaks and improve the economy.

Ask the drug called "Vitral-E" developed according to the documentation.

Sources of information

1. Sat. instructions for disease control fish. Part I. M., "AMB-agro", 1998, p.142-149.

2. Handbook of fish diseases. Ed. Osetrova BC / M: Agropromizdat, 1989, s.

3. Patent RU No. 2187314, CL. MKI7AC 33/18, AK 61/00, AK 1/18, 2002.

1. The drug for the treatment of infectious diseases of bacterial etiology, including metal and iodine potassium iodide, the prolongator and water, characterized in that as prolong the Torah contains 1,2-propylene glycol and optionally contains vitamin a (retinol-acetate), vitamin E (alpha tocopherol acetate), vitamin b1(thiamine hydrochloride), vitamin b2(Riboflavin), vitamin b6(pyridoxine hydrochloride), vitamin b12(cyanocobalamin), iron carbonate, magnesium phosphate, manganese sulfate, copper sulfate, zinc sulfate, cobalt chloride, sodium chloride, succinic acid, glucose, ethyl alcohol rectified (96%) in the following ratio, g/100 ml distilled water:

The cobalt chloride, reagent-grade
Iodine metal, CHP0,112-0,187
Potassium iodide, reagent-gradeof 0.337-0,562
Vitamin E (alpha tocopherol acetate)to 0.060-0,100
Vitamin a (retinol-acetate)3,750-6,250 thousand ME
Vitamin B1(thiamine hydrochloride)0,052-0,087
Vitamin b2(Riboflavin)0,037-0,062
Vitamin b6(pyridoxine hydrochloride)0,034-0,056
Vitamin b12(cyanocobalamin)0,026-0,044
Iron carbonate, reagent-gradeof 0.337-0,562
The magnesium phosphate, reagent-gradeof 0.337-0,562
Manganese sulfate, reagent-grade0,172-0,287
Copper sulfate, reagent-grade0,090-0,150
Zinc sulfate, reagent-grade0,315-0,525
0,071-0,119
Sodium chloride, reagent-grade0,589-0,981
Succinic acid, OFS0,225-0,375
Glucose, analytical grade0,172-0,287
Ethyl alcohol, rectified (96%)0,300-0,500 ml
1,2-propylene glycol0.900 for 1,500 ml

2. The method of treatment of infectious diseases of bacterial etiology, comprising adding to the feed of a drug, characterized in that the quality of drug use the drug according to claim 1, which set the feed at doses 1,00-1,50 mg per 1 kg of weight of fish once a day for 5-7 days.



 

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FIELD: agriculture.

SUBSTANCE: method of manufacturing feed for pacific salmon young fishes involves mixing fish meal, opossum shrimps, algal meal, dry skim milk, crushed wheat grains, premix, hydrolytic yeast, fish oil in the following ratio of components in wt %: fish meal - 40.0-30.0, opossum shrimps - 30.0-50.0, algal meal - 1.0-1.0, dry skim milk 4.0-4.0, crushed wheat grains 15.5-6.5, premix 1.5-1.5, hydrolytic yeast 6.0-5.0, fish oil 2.0-2.0; the opossum shrimps are preliminary dried up to moisture content of raw material equal to 45-50%, after mixing the components are crushed and granulated by dry pressing method; the obtained granules are crushed with dispersion into grits with diameter from 0.4-0.6 mm to 1.5-2.0 mm and 2.5-3.0 mm.

EFFECT: increasing young fishes increase, increasing survival rate, preventing development of alimentary diseases, reducing percentage of precocious males, increasing percentage of spawners return.

2 tbl, 2 ex

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