Medical product for calf diarrhea treatment

FIELD: medicine; veterinary medicine.

SUBSTANCE: medical product contains polyvinylpyrolidone, Furacilinum, glucose, Acidum ascorbinicum and sodium hypochlorite at the certain component proportion.

EFFECT: reduction of diarrhea duration on 36% (to 2.8 days); calf safety at level of 95% and additional weight increase on 15-44% after treatment, reduction of medical products consumption.

2 tbl, 2 ex

 

The invention relates to veterinary medicine, in particular drugs for the treatment of diarrhea in animals.

Known drug - solution of gentamicin (1 ml of solution contains 40 mg of gentamicin in the form of sulfate, which has a wide spectrum of action), used to treat and prevent infections of the gastrointestinal tract, respiratory and urinary tract in a dose of 3 mg/kg of body weight of the calf 2 times a day for 3-5 days. (See Guidance on the application of a solution of gentamicin in veterinary medicine. Approved by the Deputy head of the veterinary Department).

However, the use of antibiotics in mass diseases are often carried out without taking into account the laboratory diagnosis of drug sensitivity to pathogenic microflora, requiring additional time to research and, as a consequence, accompanied by the disruption of the microbial balance in the digestive tract secondary dysbacteriosis. In addition, the conditions for the development of more selective pathogens and drug-resistant strains of microorganisms in the background accompanied by a reduction in resistance of the organism.

Known drug for the treatment of diarrhoea in calves is a solution of sodium hypochlorite at a concentration of 300-500 mg/l in a volume of 500 ml, which vapiwala for 30 minutes before feeding 2 times a day until recovery within 35 days. Active sodium hypochlorite solution produced by electrolysis of sodium chloride solution on the apparatus EDO-4. (See "The effectiveness of dosage forms of sodium hypochlorite", Journal of veterinary medicine", No. 4, 1992, p.14).

However, active sodium hypochlorite solution set in large doses (500 ml), does not provide a high therapeutic efficacy in an associative basis, and, being a powerful oxidant in large doses, reduces the effect of symptomatic means. In addition, as shown, the feeding of high doses (500 ml) of sodium hypochlorite is difficult because of its strong odor, at a concentration of 500 mg/l calves refuse to drink the solution even in a mixture with milk.

Known drug lers for the treatment of diarrhoea of calves. Lars helps to remove toxins from the gastrointestinal tract and prevents the rennet casein of does, normalizes water-salt balance, has a bacteriostatic effect. The drug is a set - packing powdery substances, put up in three packages. Package # 1 - polyvinylpyrrolidone (PVP) - 200 g package # 2 - glucose 200 g package # 3: potassium chloride 2 g, sodium chloride 50 g aminouksusnoy acid (glycocol) 30 g calcium lactate 10 g ascorbic acid 5 g, ethacridine lactate 2 g furatsilin 1, the Drug is prepared in the form of a solution from the contents of the three packages in 10 l of water (70-80° C). With the preventive purpose of the calves during the first 6 vipac after birth, feeding 250 ml each portion of colostrum, for therapeutic purposes calves the next 2 feeding milk substitute solution Larsa in volume of one liter at a time, in the subsequent portion of milk add 250 ml of Larsa to recovery. (See Instructions for manufacturing and production control drug lers. Approved by the Ministry of Agriculture of the USSR. The main veterinary Department November, 1985 Interim guidance on the use of the drug Lars - prototype).

However, this drug is cumbersome due to the necessity of preparation of a solution directly into the economy, where conditions generally do not meet the requirements of the veterinary-sanitary standards required for the preparation of medicinal products (microbial contamination during preparation and periodic mixing during the day). In addition hindered the application instructions specified drugs in large volumes with poor performance, high flow components.

It is necessary to develop a comprehensive drug for the treatment of diarrhoea of calves, efficiency-enhancing treatment that promotes safety calves, reducing treatment time with minimal doses of drugs is a, loss reduction in average daily gain, to the exclusion of incidental and negative effects when using the drug.

This technical result is achieved by the fact that the medicinal product, including polyvinylpyrrolidone, furatsilin, glucose, ascorbic acid additionally contains sodium hypochlorite with a concentration of 300-350 mg/l, with the following ratio of components, g/l: polyvinylpyrrolidone 9-10, furatsilin 5-6, glucose 18-20, ascorbic acid 4 sodium hypochlorite to liters, while the daily dose of the drug, administered for 2-3 times with colostrum or milk is not more than 150 ml

The essence of the claimed medicinal product is that studies the applicant identified the optimal combination of drugs (part of the comprehensive drug lers and sodium hypochlorite), which significantly reduced the daily dose of the drug, administered to the newborn calves (6-8 times), reduced consumption, polyvinylpyrrolidone and glucose. So with one liter of Larsa consumed 20 g of polyvinylpyrrolidone and 20 g of glucose, while 150 ml (daily dose) declared funds 1.5 g of polyvinylpyrrolidone and 3.0 g of glucose (average) while achieving a high therapeutic effect in excess of this figure, as in the use of Larsa, and sodium hypochlorite. Capocasale comparative tests, result from the use of sodium hypochlorite, having antibacterial, detoxifying, anti-fungal, anti-inflammatory effect in the treatment of diarrhoea of calves was lower than in the treatment claimed by the tool. A similar result was obtained in comparative tests using Larsa.

Research to identify the optimal ratio of components in the medicinal product were conducted in three experiments 570 calves up to 1.5 months of age 9-10 calves in the group. Each experience was different from the previous daily dose of the drug (75, 150, 225 ml), giving to drink with colostrum or milk in three steps, i.e. at 25, 50, 75 ml for the reception, respectively. In the experiments, we studied the efficiency of the medicines when the content of sodium hypochlorite from 250 to 450 mg/l in combination with four sets (sets), consisting of polyvinylpyrrolidone, furatsilina, glucose. Each kit is different from the previous higher content of substances, the content of ascorbic acid in all the sets remained at the level of 4 g/HP Kit # 1: polyvinylpyrrolidone - 8, furatsilin 4, glucose 15 g/l, set No. 2 - 9; 5; 18, kit No. 3 - 10,0; 6,0, kit # 4 - 11; 6,5; 23 g/l, respectively.

Research results are reflected in table 1. Experiments on the application of sodium hypochlorite with concentratie mg/l are not reflected in this table due to false the difference between the results when the concentration of 400 mg/L.

As can be seen from table 1, the duration of treatment of diarrhoea of calves was significantly reduced with increasing content of the activity of sodium hypochlorite in the medical facility. For example, in the first experiment using the first set of other components, the duration of treatment decreased from 126 hours when the content of sodium hypochlorite 250 mg/l to 89 hours, while the content of 400 mg/l (reduction in the duration of treatment 29%). At higher concentrations of polyvinylpyrrolidone furatsilina, glucose (sets 2 and 4), this indicator has increased from 29%to 39%, which is typical for all three experiments. The increase in the concentration of these substances in the claimed medicinal product (from 1 to 4 sets) also influenced the reduction of the duration of treatment, when the concentration of sodium hypochlorite 250 mg/l in the first set, the duration of treatment was 126 hours.

When using the fourth set of 109 hours (reduction of the duration of treatment from the previous 2%). As can be seen from studies of the dynamics of reducing the duration of treatment was increased in all cases, the use of the second and third sets and was unreliable when using the fourth. At the same time, given the increasing concentration of sodium hypochlorite from 250 to 400 mg/l duration of treatment with what was rasalas 13% when its concentration 250 mg/l (126 to 109 hours), 25% when the concentration of sodium hypochlorite 400 mg/l (from 89 to 67 hours). Similar dynamics reduce the duration of treatment was maintained in all three experiments. The optimum content of the components of the medicinal product on the basis of this experience, you should consider sodium hypochlorite with a concentration of active substance from 300 to 350 mg/l when the content of the polyvinylpyrrolidone 9-10 g/l, furatsilina 5-6 mg/l, glucose 18-20 mg/l with a daily dose of 150 ml. the Duration of treatment with this ranged from 87 hours when the concentration of sodium hypochlorite 300 mg/l to 63 hours at concentrations of 350 mg/l, i.e. from 3.6 to 2.6 days. The use of funds for treatment of diarrhea at a dose of 225 ml provided inaccurate reducing duration of treatment (from 84 to 63 hours) relative to the dose in 150 ml.

Comparative efficacy of treatment of severe diarrhea drugs analogues and the claimed therapeutic agent are shown in table 2.

Analyzing the data of table 2 it should be noted that in contrast to the use of the claimed medicinal products in the treatment of severe forms of (toxic) diarrhea is possible to reduce the duration of disease on average by 36%, to reduce the mortality of calves on 53-71%, while the gain in live weight at 30 days after treatment were higher on 15-44%. Safety of the calves increased from 80 to 95%.

td align="right" namest="c0" nameend="c7"> Table 2
№ p/pIndicatorsThe experimental group
12345
gentamicinHypo-chlorite sodiumLarsthe claimed tool
1The number of sick animals, a goal.130135135140145
2The live weight of the experimental calves, kg32±238±534±332±334±2
3The dose of the medicinal product3 mg/kg of body weight of the calf 2 times a day500 ml 2 times a dayaccording to the instruction50 ml 3 times a day75 ml 2 times a day
4Mean disease duration, days4,54,2the 4.72,82,9
5Palo goals26162078
6Safety, %80888595 94
7Average daily weight gain (g) at 30 days after treatmentto 300.7of 306.7375,3435,2430,4

Production (manufacturing) of the drug is hanging powdery substances according to the invention is based g/l, for example (polyvinylpyrrolidone 9 g, furatsilin 5 g, 18 g glucose, ascorbic acid 4 g, sodium hypochlorite with a concentration of 300-350 mg/l to liters). A portion of powdery substances made in the calculation for a certain number of finished medicinal product, for example 10-20-50-100 liters and more.

The powdered mixture of four substances specified in the formula, pre-screened, lumps are crushed, all filled to capacity corresponding to the size and quantity of the sample, filled with sodium hypochlorite with a concentration of 300-350 mg/l, thoroughly mixed until complete dissolution of all components (homogeneous suspension).

The resulting tool is Packed in a prepared container (0.5, 1,5, 2,0, 2,5 l glass, plastic bottles, cans), tightly sealed, and labeled. Store protected from light place at a temperature of from +1 to +20°C.

Example 1. At the farm, at the first sign of disease of calves (10 goals, in a separate group) opened the container with Lekarstvo the m by means of the calculation of 150 ml to 1 calf per day, i.e. polutoralitrovom bottle (150 ml × 10 goals) and vapiwala with milk or colostrum three times 50 ml per feeding on each calf.

Example 2. At the first sign of disease of calves (20 goals in a separate group) revealed two capacity 1.5 litres of medicines (150 ml × 20 goals) and vapiwala twice in 75 ml (morning and evening) for one feeding.

Thus, the claimed medicinal product for the treatment of diarrhoea in calves provides high efficiency, expressed in enhancing the security of calves, the reduction of treatment time, with a small dose of the drug, increased average daily gain after treatment. In addition, significantly reducing the consumption of polyvinylpyrrolidone and glucose.

The use of a drug in the treatment of diarrhoea in calves in 20 farms Altai region confirmed its high efficiency.

Drug for the treatment of diarrhoea in calves, including polyvinylpyrrolidone, furatsilin, glucose, ascorbic acid, characterized in that it additionally contains sodium hypochlorite with a concentration of 300-350 mg/l at the following ratio of components, g/l:

polyvinylpyrrolidone9-10
furatsilin5-6
gluco is and 18-20
ascorbic acid4
sodium hypochloriterest

at the same daily dose of the medicinal product, giving to drink 2-3 reception is not more than 150 ml



 

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