Isoflavon derivatives of tectorigenine, their production and virus inactivating agent containing these derivatives as an active ingredient

FIELD: chemistry.

SUBSTANCE: invention relates to the new isoflavon derivative of tectorigenine compound of formula (II) , where R1 represents H, NH2 or SO3M; R2 represents OR'; R3 represents H or -CH2NR"; wherein R' represents H, -CH2COONa or -CH2CH2NMe2; NR" represents or -NMe2; M represents H, Na, K or N+H(CH2CH2OH)3, it also relates to virus inactivating agent having this derivative as an active ingredient and to the method for preparation of the injections on its basis.

EFFECT: developing of production method for the injections on basis of tectorigenine.

20 cl, 10 tbl, 2 dwg,10 ex

 

The text descriptions are given in facsimile form.

1. Derived lektoriranje, having the chemical name 5,7,4′-trihydroxy-6-methoxy-isoflavone of the formula (II)

where R1represents N, NH2or SO3M;

R2represents'OR′;

R3represents H or-CH2NR′′;

where R′ represents H, -CH2COONa or-CH2CH2NMe2; provided that R1, R3and R′ are not both hydrogen;

NR′′ is aor-NMe2;

M represents H, Na, K or N+H(CH2CH2OH3).

2. Derived lektoriranje according to claim 1, wherein R1represents the SO3M′′where M′′ represents H, Na, K or N+H(CH2CH2OH)3having the formula (III)

3. Derived lektoriranje according to claim 2, characterized in that M′′ represents Na, having the formula (IV)

4. Derived lektoriranje according to claim 2, wherein R1represents-SO3-N+H(CH2CH2OH)3having the formula (V)

5. Derived lektoriranje according to claim 1, wherein R1represents NH2, R2HE is a, R3represents H, having the formula (VI)

6. Derived lektoriranje according to claim 1, wherein R1represents H, R2represents-och2COONa and R3represents H, having the formula (VII)

7. Derived lektoriranje according to claim 1, wherein R1and R3represent H, R2is a co2CH2NMe2having the formula (VIII)

8. Derived lektoriranje according to claim 1, wherein R1represents H, R2HE is a, R3represents-CH2NR′′where NR′′ is ahaving the formula (IX)

9. Derived lektoriranje according to claim 1, wherein R1represents H, R2HE is a, R3represents-CH2NMe2having the formula (X)

10. Derived lektoriranje according to claim 5, characterized in that it is the Oh pharmaceutically acceptable salt.

11. Derived lektoriranje of claim 10, characterized in that the salt is a hydrochloride.

12. Derived lektoriranje according to claim 7, characterized in that a represents a pharmaceutically acceptable salt.

13. Derived lektoriranje indicated in paragraph 12, characterized in that the salt is a hydrochloride.

14. Derived lektoriranje of claim 8, wherein a is a pharmaceutically acceptable salt.

15. Derived lektoriranje through 14, characterized in that the salt is a hydrochloride.

16. Derived lektoriranje according to claim 9, characterized in that a represents a pharmaceutically acceptable salt.

17. Derived lektoriranje on item 16, characterized in that the salt is a hydrochloride.

18. Antiviral medication that contains an effective dose derived lektoriranje formula (II) as the active pharmaceutical component and a pharmaceutically acceptable auxiliary components.

19. Antiviral medication to claim 19, characterized in that the said drug is a drug for injection.

20. The method of producing drug for injection containing derived lektoriranje formula (II) as the active pharmaceutical component, in which 5-80 wt. including derivative is aktiivinen formula (II) and 20-150 wt. including glucose for injection is dissolved in 700-800 wt. including water for injection, after complete dissolution add water for injection to a total volume equivalent to 1000 wt. o'clock, and after filtration through a glass sinter funnel with a G4, conventional packaging and sterilization obtain a pale yellow transparent liquid preparation for injection, the glucose which is 2-15%, and the content of the active pharmaceutical component is 5-80 mg/ml



 

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33 cl, 26 tbl, 13 ex

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