Method of children treatment suffering from superior digestive disorders associated with helicobacter pylori

FIELD: medicine; gastroenterology.

SUBSTANCE: therapy course includes medicinal agents aimed at eradication of Helicobacter pylori. Additionally oral intake of medium-mineralised sulphide water is prescribed. Intake is carried out every day 3 times a day 40-60 minutes before meals in dosage 3-5 ml/kg. Water therapy course includes 21-30 days. Invention enables to improve eradication effect regarding Helicobacter pylori, expedite recovery, increase disease remission owing to straight bactericidal action of mineral water to Helicobacter pylori, increase redox enzyme activity under the influence of mineral water, optimize energy metabolism.

EFFECT: increased treatment efficiency.

3 tbl, 2 ex, 2 dwg

 

The invention relates to medicine, in particular for pediatric gastroenterology, namely the treatment of diseases of the upper gastrointestinal tract, associated with Helicobacter pylori.

For the last 17 years after the discovery of Helicobacter pylori was passed several stages, in which were developed the most accurate methods of diagnosis, treatment and prevention of diseases associated with Helicobacter pylori.

Currently, the main condition of anti-relapse treatment of gastritis, gastroduodenitis and ulcers recognized conducting eradication antihelicobacter therapy, which is used for three - or four-part (quadrature) scheme that meets the following requirements: 1) destruction .pylori not less than 80% of cases; 2) the occurrence of side effects is less than 5% of cases; the duration of treatment no more than 7-10 days.

The well-known scheme with the use of proton pump blocker in combination with clarithromycin (500 mg twice daily) and amoxicillin (1000 mg twice a day) for at least 7 days (Vasiliev J.V., peptic Ulcer disease: pathogenesis, modern strategy of diagnosis and treatment // J. "Practical medicine". - Kazan, 2003. No. 4. - P.56-60.).

The well-known scheme using colloidal bismuth subcitrate - 240 mg twice a day for 7 days (Isakov V.A., Shcherbakov is L Proposals for the use of the recommendations from the second of the Maastricht agreement on eradication .pylori. // J. "prospects of Clinical gastroenterology, Hepatology." M., 2002. No. 4. - Pp.31-34).

In this scheme applies a combination of colloidal bismuth subcitrate - 240 mg two times a day together with clarithromycin 250 mg twice a day and furazolidone 100 mg twice a day for 7 days.

This diagram, taken as an analogue, has some drawbacks: for furazolidone marked the development of resistance of Helicobacter pylori, the percentage of eradication is of 73.7%persistent pain and dyspeptic syndromes therapy, short term remission of the disease.

The well-known scheme: a proton pump blocker at standard dose twice daily + metronidazole 250 mg four times daily + tetracycline 500 mg four times per day (Abdulkhakov R.A., Modern principles of treatment of peptic ulcer // KAZ. The honey. J." - 2002. - T No. 3. - S-236).

However, when conducting eradication therapy in recent years has revealed serious problems in connection with the growing resistant strains of Helicobacter pylori to antimicrobial agents.

Resistant strains of Helicobacter pylori are more difficult pharmacological eradication and reduce the effectiveness of modern treatment regimens by 30-50%, which makes their use uneconomical.

To date, all of the above suggests to seek new innovative ways, conducive to a more effective eradication therapy. One of these ways, in the conditions of the region (the Republic of North Ossetia-Alania), can be use in the treatment of children suffering from gastroduodenal pathology associated with Helicobacter pylori, moderately mineralized sulphide mineral water.

The aim of the present invention is to achieve a substantial eradication effect against Helicobacter pylori in children with gastroduodenal diseases, fast reverse development of gastroduodenal pathological processes, prolonging remission, positive influence on the functional state of the cells, resulting in optimization of energy metabolism in these cells and the organism as a whole.

In the presented method as criteria of results of treatment were used measures of the extent gelikobakterna pylori infection. This was determined by the terms of relief of pain and dyspeptic syndromes, effect of eradication therapy using histology and urease tests, indicators of activity of succinate dehydrogenase and alphaglucosidase in lymphocytes and duration of remission of the disease.

The closest to the essential features of the claimed invention is a method of treatment of children with diseases of VOPT associated with HP, including the surrounding drug use, aimed at the eradication .pylori with additional admission sulfide mineral water (Ignatenko L.V. and other Therapeutic effect when using sulfide brackish water Sinacola field in the treatment of diseases of the digestive tract in children of different ages, Ukrainian medical journal, 2001, No. 6 (26), s-138), taken as a prototype.

The prototype of the invention has the following essential features: the use of drugs aimed at the eradication of Helicobacter pylori, and sulfide mineral waters in children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, to achieve eradication effect after therapy, relief of pain and dyspeptic syndromes, healing ulcers and erosions.

The disadvantage of the prototype is that in the above-mentioned method of treatment uses low-mineralized sulphide water, does not specify what degree of eradication of H. pylori how to change the indices of the activity of succinate dehydrogenase and alphaglucosidase in lymphocytes and duration of remission after therapy.

The claimed invention is directed to the solution of this problem involves the development of a treatment for children with diseases of the upper parts pediatricain the th path, associated with Helicobacter pylori, using natural factors, in particular moderately mineralized sulphide mineral water are included in the scheme of eradication therapy.

The solution to this problem provides a pronounced effect of eradication from Helicobacter pylori, fast relief of pain and dyspeptic syndromes, prolonging remission.

To achieve this, the technical result of the claimed method of treatment of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, contains the following significant features: a treatment involving the use of drugs aimed at the eradication of Helicobacter pylori, and sulfide mineral water, characterized in that a treatment with a daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days.

Control gelikobakterna pylori infection is carried respiratory test 4-6 weeks after eradication therapy in combination with moderately mineralized sulphide water. During treatment revealed a positive effect of sulfide mineral water on the functional state of cell balance improved cells with high and low activity of the enzymes LDH and LGFD, activation of cells, privadas the strengthening of energy metabolism in the cell, the increase in the functional activity of mitochondria in lymphocytes after treatment).

In relation to the prototype of the claimed invention has the following distinctive features: presents a method for the treatment of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, includes the use of drugs aimed at the eradication of Helicobacter pylori, with additional daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days, but not low-mineralized sulfide water that is specified in the prototype.

Between the features and the result is the following causal relationship: the treatment of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, including the use of drugs aimed at the eradication of Helicobacter pylori, with additional daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days, 3 times higher than the effect of eradication treatment, including the use of drugs aimed at the eradication of Helicobacter pylori, without additional daily intake of relaminarization sulfide in water the dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, course 21-30 days. In addition, the duration of remission in patients of the main group was on average 2-3 years, and patients of the control group and 0.5-1 year.

64 (58,4%) of children who received treatment, including the use of drugs aimed at the eradication of Helicobacter pylori, with additional daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days during the observation period of 1 to 3 years of aggravation was not observed. The corresponding figures in the control group was 3 (15,5%) children.

According to the authors ' knowledge, the set of essential features that characterize the essence of the invention, is unknown, which allows to make a conclusion about conformity of the invention, the criterion of "novelty".

According to the authors, the essence of the claimed invention to a person skilled should not be explicitly known level of medicine, since it is not detected by the above method of treatment of diseases of the digestive system associated with Helicobacter pylori, including the use of drugs aimed at the eradication of Helicobacter pylori, with additional daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days, which allowed yet to conclude that the criterion of "inventive step".

Drinking mineral sulfide water children's sanatorium "Tamis" refers to waters of neutral, high salinity, chloride-sulphate-calcium composition with a high content of magnesium. Moderately mineralized sulfide water contains hydrogen sulfide total - 0,0816 g/l, free - 0,0490 g/l, color - yellow, the smell is hydrogen sulfide, the taste is fresh, sediment - black. The hydrogen sulfide that is part of the sulfide mineral water possesses antimicrobial activity, has a positive effect on blood circulation in the digestive system, improves trophic function, leading to increased delivery of nutrients necessary for the synthetic activity of the main digestive glands. Oral sulfide mineral water enhances leukocyte migration from the mucosa into the lumen of the stomach and thereby reduces its inflammatory infiltration, helps dyspeptic syndrome, increases the efficiency of eradication .pylori in the stomach when .pylori - associated diseases through direct bactericidal effect on Helicobacter pylori, improving trophic processes in the mucous membrane of the stomach, the activity of redox enzymes, thus reducing the adhesive properties of Helicobacter pylori.

The set of features that characterize the essence of izopet the tion, in principle, can be used repeatedly in medicine with the technical result consists in the treatment of children with digestive diseases associated with Helicobacter pylori, including the use of drugs aimed at the eradication of Helicobacter pylori, with additional daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days, which allows to make a conclusion about conformity of the invention, the criterion of "industrial applicability".

This method is as follows.

Children with pathology of the upper gastrointestinal tract, associated with Helicobacter pylori, along with the drugs included in the scheme of eradication therapy on the basis of drug De-Nol (240 mg twice daily) in combination with two antibiotics (Flemoxin-Solutab 500 mg three times a day; fromilid/ clarithromycin 250 mg 2 times a day) and makmiror 200 mg 2 times per day, duration of treatment is 7 days, appoint moderately mineralized sulphide mineral water from the calculation of 3-5 ml/kg in one dose 3 times a day for 40-60 minutes before meals, depending on the acid-forming function of the stomach. Control gelikobakterna pylori infection is carried respiratory test 4-6 weeks after the era of icaciones therapy in combination with moderately mineralized sulphide mineral water.

We surveyed 130 children with gastritis, gastroduodenitis and peptic ulcer 12 duodenal ulcer associated with Helicobacter pylori. All the children were divided into 2 groups.

The first (main) group consisted of 110 children treated with mineral water in conjunction with eradication therapy. The second (control) group consisted of 20 children who received eradication therapy without combining it with mineral water. After careful antibioticos history was assigned to eradication therapy, on the basis of drug De-Nol in combination with two antibiotics (Flemoxin-Solutab and fromilid/clarithromycin). Duration of treatment was 7 days. According to previous studies, all these schemes give an average of 70-80% of eradication. Children received sulfide mineral water at a rate of 5 ml/kg in one dose 3 times a day for 40-60 minutes before meals, depending on the acid-forming function of the stomach. We've analyzed the nature of the clinical course and the degree of eradication in children in combination with mineral water and without combination.

Studies have shown that the second group of children (not receiving moderately mineralized sulfide water) pain and dyspeptic syndromes were stopped only by the end of therapy, while using the mineral water, abdominal pain and dyspeptic complaints disappeared significant is entrusted earlier (figure 1).

To assess eradication effect of Helicobacter pylori moderately mineralized sulphide water, we followed the dynamics of the breath test in children of both groups after 4 weeks after antihelicobacter treatment. The data of the breath test of the main group (n=34)received antihelicobacter therapy in combination with moderately mineralized sulfide water before treatment was 7,05±2.5 mm after antihelicobacter therapy - 1,7±0.17 mm (p<0.01). Whereas in the control group (n=20), where the children received only eradication therapy, indicators breath test before treatment was 8,05±1,38 mm, and after therapy is 3.45±1.15 mm (p<0.01) (figure 2).

To assess the degree of Multisystem disorders of energy used quantitative cytochemical method for determining the activity of succinate dehydrogenase and alphaglucosidase in peripheral blood lymphocytes by Nartsissov, which allowed to assess the redox processes in lymphocytes. Thus, the following is assessed morphometric characteristics of the distribution of lymphocytes in accordance with cytochemical activity of these enzymes: Q - average activity, And the asymmetry factor, E is the coefficient of kurtosis, V - coefficient of variation, N - entropy information (see tab. 1, 2).

Along with invites the m clinical data on a background of reception, moderately mineralized sulfide water indicators of activity of succinate dehydrogenase and alpha-glitserofosfatdegidrogenazy normalized much more efficient in comparison with children of the second group. So, when studying enzyme profile of lymphocytes in the examined children of the main group average activity of succinate dehydrogenase before treatment was 22,36±or 4.31 g/limp (at a rate of 18,5-19,5 g/limp), after - values decreased significantly, reaching 18,81±0,97 g/limf (p<0,001). In the comparison group, where children received eradication therapy without combination with moderately mineralized sulphide water, dynamics of the studied enzymes did not differ with statistical significance. A significant decrease of succinate dehydrogenase did not occur (20,04±2,5 gr/limp).

Marked by a sufficient reduction of the asymmetry factor at the end of therapy in the study group with -0,052±of 0.5 to 0.25±0,13( p<0,001) (at a rate of 0-0,5), which suggests that the normalization of the balance of cells with high and low activity in the second group there is a depression dehydrogenases, which is reflected in a negative coefficient of skewness, which amounted to ensure -0,54±0.5, and after the treatment coefficient remained negative -0,52±0,2 (p<0,05), which proves the lowefficiency eradication terap and without combination with moderately mineralized sulphide water.

In children of the first group compared with children in the second group revealed a sharp decrease in the coefficient of kurtosis. So, the children of the first group this parameter was before treatment -0,67±0,08 (at a rate of-0.5 to +0.5 in), and after the treatment was significantly changed in 2.3 times and reached 0,029±0,4 (p<0,001). A positive trend suggests that as a result of eradication therapy in combination with moderately mineralized sulfide water is an increase in the number of cells with typical activity, thereby increasing the intensity of metabolic processes in the cell. In the control group before treatment indicator made of-0.62±0,9, after eradication therapy without combination with moderately mineralized sulfide water ratio remained virtually unchanged -0,60±0,4 (p<0,05) (table 1,2). About significant positive dynamics characteristics of the metabolic activity of lymphocytes in children of the first group compared with children who did not receive mineral water, show and other morphometric parameters of mitochondrial activity in these cells.

Conducting a correlation analysis between clinical and laboratory cytochemical data, we have identified a direct relationship: the deeper and longer the pathological process, the more pronounced changes cytochemical indicators EN zymes the s dehydrogenase and alphaglucosidase (r=0,5).

In addition, the duration of remission in patients of the main group was on average 2 years, and patients of the control group is 0.5 years.

64 (58,4%) children who received eradication therapy in combination with mineral water, during the observation period of 1 to 3 years of aggravation was not observed. The corresponding figures in the control group was 3 (15,5%) children (table 3).

Table 1
Dynamics dehydrogenase lymphocytes
The studied parametersStandardsThe main group n=14pThe second group (n=14pControl group n=10P
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatmentBefore the treatmentAfter the treatment
Q (medium activity)18,5-19,5 granules/limp.22,36±1,3118,81±0,97<0,00121,43±1,719,04±2,5<0,0521,33±1,720,04±2,5<0,05
And (coefficients. asymmetry) 0-0,5-0,22±0,50,25±0,13<0,0010,064±0,50,36±0,2<0,01-0,54±0,5-0,52±0,2<0,05
E (coefficients. kurtosis)of-0.5 to 0.5-0,67±0,080,029±0,4<0,001of-0.62±0,90,15±0,4<0,01-0,61±0,9-0,60±0,4<0,05
V (coefficients. variations)26,7-29,4%36,9±2,225,28±1,9<0,00137,9±1,628,25±1,7<0,0536,8±1,635,25±2,1<0,05
H (entropy information)0,73-0,800,54±0,070,75±0,07<0,010,56±0,050,70±0,05<0,010,52±0,050,50±0,05<0,05

Table 2
Dynamics of indicators of alphaglucosidase lymphocytes
The studied parametersStandardsThe main group n=14p The second group (n=14Comparison group n=10p
Before the treatmentAfter the treatmentBefore the treatmentAfter the treatmentBefore the treatmentAfter the treatment
Q (medium activity)11-13 granules/lim15,06±4,811,43±1,02<0,00115,58±4,712,24±1,215,58±4,714.24 from±1,2<0,05
And (coefficients. asymmetry)0-0,5-0,05±0,60,34±0,2<0,001-0,09±0,50,38±0,2-0,09±0,5-0,38±0,2<0,05
E (coefficients. kurtosis)of-0.5 to 0.5-0,06±1,30,17±0,2<0,001-0,11±1,080,08±0,3-0,11±1,080,11±0,3<0,05
(The coefficient. variations)26,7-29,4%38,36±11,728,07±1,4<0,00137,78±11,728,38±2,838,78±11,735,38±2,8<0,05
H (entropy information)0,60-0,700,88±0,040,65ଐ,02 <0,010,86±0,040,66±0,470,89±0,040,78±0,47<0,05

Table 3
ExaminedThe main groupThe control group
number11030
The average duration of remission (months)26,1±0,484,6±0,35

Thus, the data obtained indicate that the use of moderately mineralized sulphide mineral water has a significant effect of eradication against Helicobacter pylori in children with gastroduodenal diseases, promotes rapid reverse the development of gastroduodenal pathological processes, increases the remission period, a positive effect on the functional state of the cells, resulting in optimization of energy metabolism in these cells and the organism as a whole.

Example 1

Patient Elizabeth, age 15, enrolled in 13 Department Ronald McDonald 22.12.2003 years with a diagnosis of Chronic gastroduodenitis? Complaints at admission: cramping pain in the epigastric area and piloroduodenalnoy, "hungry". The girl was worried about vomiting, heartburn and belching eaten food. Duration is lnost disease up to 1 year. Hospitalization primary. Heredity burdened by the paternal line (father suffers from peptic ulcer disease). Girl medium level of physical development. Tongue coated entirely white bloom. Breath putrid. Tenderness to palpation was determined in the epigastrium, in piloroduodenalnoy zone and in the right hypochondrium. The liver is not enlarged, positive gallbladder symptoms.

Data paraclinical methods: blood and urine abnormality is not detected. Fibrogastroduodenoscopy duodenal ulcer, duodenitis, superficial gastritis. Urease test is strongly positive. Breath test - 8 mm On ultrasound of internal organs of the gallbladder wall a little condensed, heterogeneous content.

Diagnosed with peptic Ulcer disease duodenal ulcer associated with Helicobacter pylori. Chronic gastroduodenitis associated with Helicobacter pylori.

Therapy: diet therapy, triple therapy (de-Nol 240 mg 2 times a day, Flemoxin Solutab 500 mg 3 times a day, fromilid 250 mg 2 times a day). Duration of therapy was 7 days. Mineral sulfide water was administered 5 mg/kg for 21-30 days, Vit E, 1 table. 3 times a day for 2 weeks.

Pain and dyspeptic syndromes were stopped on 4th-5th day of treatment, palpation tenderness in the epigastrium and prorogued the social area disappeared on day 7 of treatment. On repeat EGD was determined scarring ulcers. Breath test was negative 2 mm, the Duration of remission of the disease was 2 years old.

Example 2

Batraz K., 13, enrolled in 13 Department 02.04. 1989 diagnosed with Chronic gastroduodenitis? Complaints at admission: cramping pain in the epigastric pain, heartburn, belching air. Disease duration up to 1 year. Hospitalized child in the hospital the first time. Family history burdened - sister gastritis associated with Helicobacter pylori.

Objective: the boy in the average level of physical development. Tongue coated entirely yellow-white bloom. Tenderness to palpation is determined in the region of the epigastrium and right hypochondrium. The liver is not enlarged, positive gallbladder symptoms.

Data paraclinical methods of research: in the General blood and urine tests pathology was not detected. Fibrogastroduodenoscopy esophagitis, superficial gastritis, duodenogastric reflux. Urease test - positive breath test - 9 mm (positive). On ultrasonography of the digestive system identified GIT. Diagnosis: Chronic superficial gastritis associated with HP, GERD, JIT.

Therapy: diet therapy, triple therapy (de-Nol 240 mg 2 times, clarithromycin 250 mg 3 times a day, makmiror 200 mg 2 times a day. The duration of eradication therapy SOS is Avila 7 days and sulfide mineral water in conjunction with eradication therapy 5 mg/kg for 21-30 days. Odenton 1 table. 3 times a day for 2 weeks, drain - Demyanova.

The pain ceased to bother the child on day 3 of therapy, disappeared palpation tenderness in the epigastric region on day 6 of therapy. Fibrogastroduodenoscopy after treatment, the mucous membrane of the stomach without marked inflammatory changes. Breath test was negative. The duration of remission was more than 2.5 years.

All of the above, allows to make the assumption that moderately mineralized sulfide mineral water in conjunction with eradication therapy has such properties that contribute not only to quickly reverse the development of gastroduodenal pathology, increase the percentage of eradication therapy, but extended periods of remission.

A method for the treatment of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, including the use of drugs aimed at the eradication of Helicobacter pylori, and sulfide mineral water, characterized in that a treatment with a daily intake of moderately mineralized sulphide mineral water at a dose of 3-5 ml/kg of body weight 3 times a day for 40-60 minutes before a meal, the rate of 21-30 days.



 

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2 ex, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine and can be applied for treatment of dystrophic diseases of musculoskeletal system: deforming osteoarthrosis or osteohondrosis. Electrophoresis is applied with saline sediment of mineral water "Amurskaya-2" within 15 to 30 minutes, for 10-15 procedures. For deforming osteoarthrosis treatment current intensity is 20 - 30 mA, and for osteohondrosis treatment - 15-20 mA. Method ensures reduced treatment duration and improved quality of life for patients with musculoskeletal system diseases.

EFFECT: reduced treatment duration and improved quality of life for patients with musculoskeletal system diseases.

2 ex

FIELD: medicine.

SUBSTANCE: method involves prescribing conservative training motor activity and feeding diet No 5 with low mineralization low carbonic acid concentration sulfate and hydrocarbonate sodium-calcium mineral water being taken. Mineral water baths with low mineralization low carbonic acid concentration sulfate and hydrocarbonate sodium-calcium mineral water are given at 36-37°C during 12-15 min with 8-10 procedures per treatment course. 2.5% succinic acid solution electrophoresis is additionally applied to interscapular zone from cathode with the other washer - anode being placed on liver and right hypochondrium projection zone using current of 15-25 mA during 15-25 min daily with 10-12 procedures per treatment course.

EFFECT: reduced intensity of digestion disorder syndrome manifestation; stabilized peroxide homeostasis; increased organism adaptation capability.

5 tbl

FIELD: medicine.

SUBSTANCE: method involves administering peloidotherapy as applications over lower extremities with sulfide mud temperature of 37-38°C during 10-15 min in 10 procedures long course alternating with carbonic-acid/hydrogen-sulfide water baths taken at 36°C during 10-15 min. The total treatment course is 10 procedures long.

EFFECT: reduced glycemia profile level; reduced lipid metabolism indices; improved regional blood circulation.

9 tbl

FIELD: medicine.

SUBSTANCE: method involves giving magnesium-sodium-hydrocarbonate mineral water of moderate mineralization degree at room temperature in the amount of 150-200 ml. 20-30 min later alternating electromagnetic field operating in low frequency bandwidth of 0.022 Hz-270 kHz is administered in scanning mode of 43 produced by Rematherp apparatus. The total treatment course is 8-10 procedures long.

EFFECT: enhanced effectiveness of treatment; stimulated reparative processes in esophageal mucous membrane.

FIELD: medicine.

SUBSTANCE: method involves prescribing low mineralization water to drink and mud applications on liver and gallbladder area. The liver and gallbladder area is to be additionally exposed to extremely high frequency bandwidth electromagnetic field treatment as 4-6 s long pulses and pauses. Then, heart zones of Zakharyin-Gedda are treated within 5-10 min in nonmodulated mode. Then paired biologically active points of gallbladder meridian VB 24 (Ri-yue) are treated 3-5 min long per each biologically active point in modulation mode as 4-6 s long pulses and pauses. The total treatment course is 15 daily procedures long.

EFFECT: enhanced effectiveness of anti-inflammatory biliary excretion system treatment; improved blood microcirculation processes, lipid peroxidation processes; accelerated injured functions recovery.

3 tbl

FIELD: medicine.

SUBSTANCE: method involves applying therapy course containing iodine-bromine baths and vaginal irrigations given every other day. Electrophoresis is administered in days free of baths and irrigations after 2 adaptation days with silt mud enriched in hydrogen sulfide water containing hydrogen sulfide in concentration of 350 mg/l. The treatment is applied to hypogastric and lumbosacral region at the level of L4-S2 vertebrae. Electric current intensity is equal to 0.05-0.1 MA/cm2 during 20 min. The total treatment course is 8 balneo- and physioprocedures long.

EFFECT: reduced peritoneal commissure process intensity; normalized vegetative nervous system and ovarian functions; improved cellular and humoral immunity; increased female fertility.

5 tbl

FIELD: medicine.

SUBSTANCE: method involves crushing shungit mineral to fraction size of 5-10 mm large and placing it into drinking water in 1:15-1:20 proportions by volume and keeping them together at room temperature 3 days long. The extract is saturated with colloid silver ions to concentration of 5000 mcg/l and 100% Volatile Australian tea tree oils are next added in the amount of 15-30% by volume.

EFFECT: accelerated wound healing including persistent ones.

2 cl, 2 dwg

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to medicinal agents containing combined inhibitor of dipeptidylpeptidase IV (DPPIV) and biguanide agent. Offered application of pharmaceutical agent implies production of preventive and therapeutic agent and method of intensified effects of active circulating GLP-1 and/or active circulating GLP-2. Besides, invention concerns method of prevention or treatment of disease connected with active circulating GLP-1 and/or active circulating GLP-2, specifically diabetes, obesity, hyperlipidemia, gastrointestinal diseases. Combined inhibitor DPPIV of formula (I) and biguanide agent, specifically phenformine, methformin or buformine stimulates action of active circulating glucagon-like peptide-1 (GLP-1) and/or active circulating glucagon-like peptide -2 (GLP-2) and, therefore inhibits destruction of GLP-1 and GLP-2, with their levels raised up with biguanide agent.

EFFECT: agent has improved efficiency.

17 cl, 12 tbl, 425 ex

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