Method of children rehabilitation suffering from superior digestive disorders associated with helicobacter pylori
FIELD: medicine; gastroenterology.
SUBSTANCE: invention can be used for rehabilitation of children suffering from superior digestive diseases associated with Helicobacter pylori. For this purpose balneo-, climatic landscaping, phyto-, music aromatic therapy, therapeutic physical training, massage and mineral water intake. All the procedures are carried out strictly defined consistency and in specified time.
EFFECT: improved psychoemotional state and continuous remission for these type of patients using solely health resort treatment.
3 cl, 2 tbl, 2 ex
The invention relates to medicine and, in particular, balneology, namely the rehabilitation of diseases of the upper gastrointestinal tract, associated with Helicobacter pylori.
The complex of therapeutic factors of the resort "Tamis includes: sanatorium treatment, internal and external use of mineral waters, therapeutic nutrition, physical therapy, including physical therapy, climatotherapy, music therapy (nature sounds), aerotherapy, herbal medicine. Aromatherapy is one of the most ancient branches of medicine, which provides for the treatment of natural essential oils.
The application of rehabilitation technology aimed at reducing or eliminating the consequences of the disease, can be considered a specialized children health as an effective stage of rehabilitation of children with chronic diseases of the digestive system.
The objective of this study was to provide a method of rehabilitation of children with inflammatory diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, a comprehensive impact balneological and climatic LanSafe-, phytotherapy, characterized in that the integrated exposure is performed with muzykoterapia, leading to eradication of Helicobacter pylori, the rapid relief of pain and var the classical syndromes, improving psychoemotional status of children, extended periods of remission.
In the presented method as criteria outcomes of rehabilitation were used indicators of the degree of eradication of Helicobacter pylori, psychosomatic status and terms of remission of the disease. This was performed for a check-up of children who received a Spa treatment in 2-3 years, determined the presence of Helicobacter pylori using non-invasive breath test and was evaluated psychosomatic status.
The most similar essential features of the claimed invention are methods of rehabilitation of diseases of the stomach and intestines (Chumakova E.F., Budun A.S. Resorts and therapeutic areas of North Ossetia. - 1986, s), taken as a prototype, which used a complex effect of balneotherapy, climatologie-, herbal medicine, physical therapy without muzykoterapia.
The prototype of the invention has the following essential features: the integrated effects of balneotherapy, climatologie-, herbal medicine, physical therapy for rehabilitation of children with inflammatory diseases of the upper gastrointestinal tract leads to improved mood and well being of children and reduce relapse.
The disadvantage of the prototype I have is that in a complex impact on the child's body was not used muzykoterapia is one of the most ancient branches of medicine, which provides treatment natural, natural essential oils and nature sounds.
The claimed invention is directed to solution of the problem consisting in the development of the method of rehabilitation of diseases of the upper gastrointestinal tract, associated with Helicobacter pylori in children with natural factors, in particular along with muzykoterapia children received sulfide baths, moderately mineralized sulphide mineral water, herbal medicine. The solution to this problem provides improved clinical and psychosomatic status, prolonging remission.
To achieve this, the technical result of the claimed invention, a method of rehabilitation of diseases of the digestive system associated with Helicobacter pylori, carried out by the integrated effect of balneotherapy, climatologie, herbal medicine and muzykoterapia daily in the following sequence: from 9.00 to 11.00 - balneotherapy - the course of 8-10 treatments, from 11.00 to 13.00 - muzykoterapia, in the course of 8-10 sessions; herbal medicine from 13.30 to 14.00 on the course of 8-10 techniques, therapeutic exercise and massage from 14.00 to 15.00, in the course of 8-10 treatments; climatotherapy from 16.00 to 17.00 within 21-30 days; receiving a mineral is th water an oral dose of 3-5 ml/kg of body weight for 40-60 minutes before a meal, course 21-30 days; as balneotherapy share sulfide bath concentration of 50-100 mg/l, temperature of 36-S°, lasting 5-6 minutes, in the course of 8-10 treatments; muzykoterapia carried out with the use of essential oils (fir, pine, chamomile, mint, lavender) and sounds of nature, the session duration 30-40 minutes.
In relation to the prototype of the claimed invention has the following distinctive features: integrated impact exercise with muzykoterapia daily in the following sequence: from 9.00 to 11.00 - balneotherapy - the course of 8-10 treatments, from 11.00 to 13.00 - muzykoterapia, in the course of 8-10 sessions; herbal medicine from 13.30 to 14.00 on the course of 8-10 techniques, therapeutic exercise and massage from 14.00 to 15.00, in the course of 8-10 treatments; climatotherapy from 16.00 to 17.00 within 21-30 days; drinking of mineral water inside at a dose of 3-5 ml/kg of body weight for 40-60 minutes before a meal, course 21-30 days; as balneotherapy share sulfide bath concentration of 50-100 mg/l, temperature of 36-S°, lasting 5-6 minutes, in the course of 8-10 treatments; muzykoterapia carried out with the use of essential oils (fir, pine, chamomile, mint, lavender) and sounds of nature, the session duration 30-40 minutes.
Between the features and the result is as follows when the Inno-effect relationship: children received the above-mentioned complex rehabilitation, improving the psychosomatic status, the degree of eradication, extended periods of remission.
According to the authors the information set of essential features that characterize the essence of the claimed invention, is not known, which allows to make a conclusion about conformity of the invention, the criterion of "novelty".
According to the authors, the essence of the claimed invention to a person skilled should not be explicitly known level of medicine, since it is not detected above method of rehabilitation using muzykoterapia in complex with Spa, climatologie, herbal medicine, and daily intake of moderately mineralized sulfide water at a dose of 3-5 ml/kg, rate 21-30 days, which allows to conclude that the criterion of "inventive step".
Drinking mineral sulfide water children's sanatorium "Tamis" refers to waters of neutral, high salinity, chloride-sulphate-calcium composition with a high content of magnesium. Moderately mineralized sulfide water contains hydrogen sulfide total - 0,0816 g/l, free - 0,0490 g/l, color - yellow, the smell is hydrogen sulfide, the taste is fresh, sediment - black. The hydrogen sulfide that is part of the sulfide mineral water, has ant the microbial activity, has a positive effect on blood circulation in the digestive system, improves trophic function, leading to increased delivery of nutrients necessary for the synthetic activity of the main digestive glands. The biological role of sulfur is extremely high. It is part of the amino acids cysteine, cystine, methionine, biologically active substances (histamine, Biotin, lipoic acid, and others). In the active centers of the molecules of a number of enzymes includes the SH-group is involved in many enzymatic reactions, including the creation and stabilization of the native three-dimensional structure of proteins, and in some cases directly as catalytic centers of enzymes. Sulfur provides the cell a delicate and complex process, such as energy transfer: transfers the electrons, taking the free orbital of one of the unpaired electrons of oxygen. This explains the high demand of the organism in the given element. Sulfur is involved in fixing and transport metal groups. She is also part of various coenzymes, including coenzyme A.
Sulfur, disinfecting the blood, increases the body's resistance to infections, has a protective effect on cells. Sulfur is involved in the oxidation reactions. Sulfur is a part of hemoglobin, found in all body tissues, necessary for synthesis of collagen, a protein that cat is who defines the structure of the skin.
Oral sulfide mineral water enhances leukocyte migration from the mucosa into the lumen of the stomach and thereby reduces its inflammatory infiltration, helps dyspeptic syndrome, increases the efficiency of eradication .pylori in the stomach when .pylori-associated diseases through direct bactericidal effect on Helicobacter pylori, improving trophic processes in the mucous membrane of the stomach, the activity of redox enzymes, thus reducing the adhesive properties of Helicobacter pylori.
Muzykoterapia provides long-lasting positive therapeutic effect and enhances the adaptive capabilities of the growing child's body, increases the body's resistance to adverse environmental factors. Lavender oil is a good antiseptic, antimicrobial, analgesic and carminative action for pain in the stomach and intestines. Peppermint, camomile, needles and essential oils (fir and pine, chamomile, mint) have a strong bactericidal effect and is used in diseases of the gastrointestinal tract. Therapeutic exercise with mild or moderate mental and physical stress, exercise, sports and applied nature (climbing stairs, rope, ball games, Hoop), wt is already neck and neck area, back; tempering climatotherapy: air baths, dry and wet wiping, immersion of the legs contribute to improving the status of immunolo child.
The set of features that characterize the invention, in principle, can be used repeatedly in medicine with the technical result consists in the method of rehabilitation of diseases of the digestive system associated with Helicobacter pylori, using muzykoterapia in complex with Spa, climatologie-, phytotherapy and receiving moderately mineralized sulfide water at a dose of 3-5 ml/kg of body weight within 21-30 days, which allows to make a conclusion about conformity of the invention, the criterion of "industrial applicability".
This method is carried out in the following way:
In the sanatorium "Tamis" were observed in 51 children with astrobiologia associated with Helicobacter pylori, in the period of complete remission. Disease duration at 31.9 per cent was more than 3 years, 41,5% 1-3 years, 26.6 per cent of patients had disease duration of no more than one year.
Upon admission to the sanatorium complaining of severe pain in the abdomen showed only 12.5% of children, but palpation of the abdominal pain was noted in more than half of children (56,9%). The pain was mostly localized in the epigastric 69,8±4.4% and piloroduodenalnoy 55,8±4.6% of areas. All children had multiorgan the Zopa is relevant pathology, the most frequently diagnosed hyapatia (79.8 per cent).
The complex of therapeutic factors of the resort "Tamis includes: sanatorium treatment, internal and external use of mineral waters, therapeutic nutrition, physiotherapy, climatotherapy, fitoterapia and muzykoterapia.
As balneotherapy use daily total sulfide bath concentration of 50-100 mg/l, temperature of 36-S°, lasting 5-6 minutes, in the course of 8-10 treatments and receive moderately mineralized sulphide mineral water inside at a dose of 3-5 ml/kg of body weight for 40-60 minutes before a meal, the rate of 21-30 days. Muzykoterapia carried out with the use of essential oils (fir, pine, chamomile, mint, lavender) and sounds of nature, the session duration 30-40 minutes.
In the improvement of adaptive reactions of the child is especially important emotional factor. When emotional stress (and the disease can be regarded as stress) occur changes in the number of functional systems of the body. In such cases, the use of essential oils. Lavender oil is a good antiseptic, antimicrobial, analgesic and carminative action for pain in the stomach and intestines. Essential oils (fir and pine, chamomile, mint) possess strong bactericidal action and note the both of them in inflammatory diseases of the gastrointestinal tract.
Sanatorium stage of rehabilitation contributed to the improvement of the General condition, disappeared tenderness to palpation of the abdomen for 4-5 day at 30.4% of children, and by the end of the first week of stay at the resort - from 69.6 per cent. The duration of treatment in the sanatorium was 21-30 days. During his stay at the sanatorium have 2 children began to complain of nausea associated with improper diet.
In the sanatorium studied the dynamics of clinical symptoms in 76 patients with astrobiologia associated with Helicobacter pylori infection on the background of rehabilitation. Before rehabilitation, the majority (71.3 per cent) of children were in the period of partial remission and only 28,3% in complete remission. The disappearance of local palpation tenderness was noted mainly for 7-8 days () 75,7%), the fourth of children (24.3%) pain had stopped earlier at 4-5 days. Dyspeptic symptoms most children (67,3%) in remission disappeared for a 4-5 day rehabilitation.
When receiving data, summarized in table (table 1), it is clear that in the earliest periods were eliminated nausea and heartburn, normal appetite and function of the large intestine.
|The terms of relief of dyspeptic symptoms in the treatment of moderately mineralized sulphide mineral water children with gastropod what logy, assotsiirovannoi with Helicobacter pylori|
|Diarrhoeal phenomenon||The number of patients with symptom||Days|
|Nausea||53 (69.7 per cent)||32 (42,1%)||21 (27.6 per cent)|
|Heartburn||24 (31,5%)||13 (17,1%)||11 (14,4%)|
|Loss of appetite||65 (85,5%)||5 (6,2%)||60 (73,7%)|
|The tendency to constipation||36 (47,3%)||6 (7,8%)||30 (39.5 per cent)|
|Burp||21 (27.6 per cent)||3 (3,9%)||18 (23.7 per cent)|
|Vomiting||11 (14,4%)||4 (5,2%)||7 (9,2%)|
In patients with pathology of VOPT associated with Helicobacter pylori, found psychogenic reactions (netgenie)belonging to the group of reactive States. The presence of chronic disease in most children is manifested significant psychological factors - depression, symptomatic lability, complicated disease, and requiring psychogenic correction.
To assess emotional status survey was conducted with 71 children with astrobiologia associated with Helicobacter pylori. The main group (n=51) underwent a complete rehabilitation of chickens is in the sanatorium "Tamis". A control group of children with similar disorders (n=20) were treated in the hospital. Method of assessment of psychosomatic status were used to lightweight lüscher test" (4 primary and 4 secondary colors), questionnaires Eysenck and Dignity.
Children up to sanatorium-resort treatment was observed depression in 50% (p<0.01), and emotional dissatisfaction and disharmony caused by emotional frustration at 20% (p<0,05) children.
The positive dynamics of emotional status was observed after a Spa treatment in 100% of patients of the main group: positive status, satisfaction, peace of mind, active pursuit of success. Children from the control group negative condition continued to persist in 11 (55%) children (p<0,05).
To evaluate the effectiveness of sanatorium-resort treatment, it is necessary to consider not only immediate, but also long-term results of treatment. The children who received sanatorium-resort rehabilitation, looked after 2-3 years, were evaluated objective status and degree of infection of Helicobacter pylori.
Analysis of remote results in 51 of the child showed that most of them after rehabilitation at the resort, there was complete remission: the majority (59; 83,1%) patients children showed clinical remission in polikurovskom period, which manifested itself in the absence Bo is avago syndrome and a significant decrease in the intensity of dyspeptic disorders, such as heartburn, belching, nausea.
Based on the study of follow-up monitoring provided data on the duration of remission in polikurovskom period. Consideration of the duration of remission was conducted in 2 groups of patients children: in the main group of children with gastroduodenal pathology associated with Helicobacter pylori receiving rehabilitation treatment in the sanatorium "Tamis" after inpatient treatment and control group children, which has not passed the rehabilitation phase.
|The average duration of remission in patients and control group (according to the follow-up monitoring)|
|Examined||The main group||The control group|
|The average duration of remission (months)||26,1±0,48||4,6±0,35|
As one can see from table 2, the most sustained remission was noted in the study group, the average duration of remission in this group was 26.1±0,48 months, and the children of the control group - 4,6±0,35 months.
Based on the data presented in table 1,2, with a significant importance to the effectiveness and necessity of rehabilitation of children with gastropod what alogia, associated with Helicobacter pylori.
In General, the assessment of clinical data the effectiveness of Spa treatment was considered as follows:
good remission in terms of more than 2 years in 28.3% of patients;
satisfactory remission in terms of one to two years - in 58.8% of patients;
- unsatisfactory - remission lasting less than one year - 12.8% of patients.
Stay in the sanatorium "Tamis" had a significant impact on the need for inpatient treatment. If of course the Spa rehabilitation hospital treatment needed to 58.8% of the children, after - 11,9% of children.
Thus, the application of rehabilitation technology aimed at reducing or eliminating the consequences of the disease, can be considered a specialized children's sanatorium "Tamis" as an effective stage of rehabilitation of children with chronic diseases VOPT associated with Helicobacter pylori: the integrated effects of balneotherapy, klimatologie-, phyto-, muzykoterapia improves the emotional status of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, long-term remission of the disease.
Sarin K., 12 years old was admitted to the gastroenterology Department of the children's Republican clinical hospital with a diagnosis of chronic gastroduodenitis? 05.02.2003. Complaints at the beginning is: dull aching pain in epigastrium, in piloroduodenalnoy area and around the navel, not associated with food intake, bothered by nausea, belching air and eaten food. Disease duration more than 1 year. The primary hospitalization. Heredity burdened by his father's side (my father was diagnosed with chronic gastritis).
Objective status: a girl of the middle level of physical development, the skin pale pink color. Tongue coated entirely dense white bloom, breath putrid. Palpation of the abdomen marked tenderness in the epigastrium, in piloroduodenalnoy the area around the navel. The liver is not enlarged, positive gallbladder symptoms. Girl irritable, tearful, silent, closed, expressionless.
Data paraclinical methods: blood and urine tests pathology was not detected. On EGDS are defined by multiple erosion (up to 0.3 cm) in the bulb 12 duodenal ulcer. Ultrasound of internal organs gall bladder is deformed, content homogeneous. Urease test dramatically positive breath test 12 mm
Therapy: diet therapy, triple therapy (de-Nol 240 mg 2 times, clarithromycin 250 mg, 2 times, makmiror 200 mg 3 times) for 10 days, choleretic drugs. After the treatment after 4 weeks on repeat gastroscopy marked scarring lesions. Breath test 7 mm Through 3 IU is ACA after hospital treatment, the child was sent to the rehabilitation phase of treatment in a children's sanatorium "Tamis".
After 2 years of sanatorium-resort treatment, the girl was examined.
Had no complaints, in the evaluation of the objective status of the pathological changes it is not revealed. Breath test on HP - 2 mm (negative). Active, interested in sports and painting. Studying a foreign language.
Example # 2
Anastasia G, 13, enrolled in 13 Department Ronald McDonald 18.02.2003 years with a diagnosis of chronic gastroduodenitis? Complaints at admission: cramping pain in epigastrium, around the navel and piloroduodenalnoy zone. Bothered by nausea, bitter taste in the mouth, disease duration 1.5 years. The primary hospitalization. Heredity is not burdened.
Objective status: a girl of the middle level of physical development, the skin pale pink color. Tongue coated entirely white-yellow tinge. Palpation of the abdomen marked tenderness in the epigastrium, in the right hypochondrium and around the navel. The liver is not enlarged, positive gallbladder symptoms. The girl with depressed mood, sleep is restless, closed.
Data paraclinical methods: blood and urine tests pathology was not detected. At endoscopy the mucosa of the stomach edematous, friable, hyperplasia of lymphoid tissue in the antrum, mucosal 12 duodenal ulcer swollen, hyperemic. Urease test positive, dy is athelny test 8 mm. therapy: diet therapy, triple therapy (de-Nol 240 mg 2 times, klacid 500 mg 2 times, makmiror 200 mg 3 times) for 10 days, choleretic drugs, tykveol, drains in Demyanova. After the treatment after 4 weeks on repeat gastroscopy inflammatory changes in the mucous membrane of the stomach is not revealed. Breath test - 3 mm in 3 months after hospital treatment, the child was sent to the rehabilitation phase of treatment in a children's sanatorium "Tamis". After 2.5 years after a Spa treatment, the girl was examined. Had no complaints, in the evaluation of the objective status of the pathological changes it is not revealed. Breath test on HP - negative, evaluation of psychosomatic status - active, good mood, engaged in ballroom dancing and aerobics.
1. The method of rehabilitation of children with diseases of the upper gastrointestinal tract, associated with Helicobacter pylori, by the integrated effect of balneotherapy, klimatologie-, phytotherapy, characterized in that the integrated exposure is performed with muzykoterapia daily in the following sequence: from 9.00 to 11.00 - balneotherapy, in the course of 8-10 treatments, from 11.00 to 13.00 - muzykoterapia, in the course of 8-10 sessions, herbal medicine from 13.30 to 14.00 on the course of 8-10 techniques, therapeutic exercise and massage from 14.00 to 15.00, n the course of 8-10 treatments, climatotherapy from 16.00 to 17.00 for 21-30 days, drinking mineral water inside at a dose of 3-5 ml/kg of body weight for 40-60 minutes before a meal, the rate of 21-30 days.
2. The method according to claim 1, characterized in that as balneotherapy share sulfide bath concentration of 50-100 mg/l, temperature of 36-S°, lasting 5-6 minutes, in the course of 8-10 treatments.
3. The method according to claim 1, characterized in that muzykoterapia carried out with the use of essential oils (fir, pine, chamomile, mint, lavender) and sounds of nature, the session duration 30-40 minutes
FIELD: chemistry; medicine.
SUBSTANCE: invention pertains to derivatives of 7-phenylpyrazolopyridine with formula (I) ,where R1, R5, R6, R40, R41 and R42 represent different hydrocarbon substitutes or functional groups, its salts or hydrates, and especially to salts of N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyradin-3-yl-N-tetrahydro-2H-4-pyranylmethylamine. The compound with formula (I), especially salts of N-cyclopropylmethyl-N-7-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-2-ethylpyrazolo[1,5-a]pyradin-3-yl-N-tetrahydro-2H-4-pyranylmethylamine, act as antagonists of the receptor of corticotrophin release factor and can be used in medicine for treating various diseases of the nervous system and the gastrointestinal tract.
EFFECT: obtaining of new biologically active substances.
162 ex, 5 tbl
SUBSTANCE: invention refers to medicine, specifically to gastroenterology and concerns treatment of duodenal ulcer associated with Helicobacter pylori. For this purpose patients have got on intravenous drip ex tempore 200 ml of ozonised 0.9%-solution of sodium chloride with ozone concentration 2.5 mg/l during 20 minutes for treatment course 10 procedures. In addition patients are introduced ex tempore with ozonised hydrocarbonate chloride sodium low-mineralised water "Mineral therapeutic table water Obuhovskaya-13" dosed 200.0 ml three times a day, 30 minutes before meal, ozone concentration is 2.5 mg/l, treatment duration - 10 days. Application of ozonised mineral water which is not containing organic substances docomposed by ozone provides rapid relief of pain and dyspepsia for patients suffering from open ulcerous defect and prevents clinical relapse of disease during 12 months.
EFFECT: rapid relief of pain and dyspepsia for patients suffering from open ulcerous defect and prevented clinical relapse of disease.
2 ex, 3 tbl
FIELD: medicine; pharmacy.
SUBSTANCE: first version implies that pharmaceutical formulation contains antibiotic and prebiotic - oligosaccharide selected from: fructooligosaccharides, galactooligosaccharides, xylooligosaccharides, maltooligosaccharides and isomaltooligosaccharides by degree of polymerization from 2 to 10, and particles sizes up to 0.3 mm and purity not less than 95%, and antibiotic with particles sizes from 20 to 200 mcm; antibiotic and oligosaccharide are included in mass proportion from 1:1 to 1:100 respectively. Second version implies that pharmaceutical formulation contains powder antibiotic with particles from 20 to 200 mcm selected from: beta-lactamase, including combinations of beta-lactams and bacterial beta-lactamases inhibitors; azalides, fluoroquinolones, amphenicoles, glycopeptides, ansamicynes, nitrofurans, phosphonic acid derivatives, cycloserine, trimetoprym, and as a prebiotic - powder oligosaccharide by degree of polymerization from 2 to 10, particles sizes up to 0.3 mm and purity not less than 95%; antibiotic and oligosaccharide are included in mass proportion from 1:1 to 1:100 respectively; mentioned compositions are intended for oral introduction and applied for bowel disbios prevention caused by antibiotic therapy.
EFFECT: stimulates lactobacilli and bifidus bacteria action.
4 cl, 9 ex
FIELD: medicine; pharmacy.
SUBSTANCE: gastrointestinal tea contains natural cardamon (seed), pomegranate (grains), long red pepper (foeti), physocarpous siberian (roots), berry apple (foeti), red bartsia (herb) of specified proportions.
EFFECT: anti-inflammatory action; enzyme normalization of gastrointestinal tract; improvement of gastric juice enzymatic activity; antispasmodic and analgesic action.
FIELD: medicine; gastroenterology.
SUBSTANCE: invention concerns selection of eradication therapy for ulcer patients associated with Helicobacter pylori. Invention implies that patients with exacerbation rates more than two times per year are initially prescribed four-component therapy, and patients with two and less exacerbation annually are initially prescribed with three-component therapy.
EFFECT: method provides registration of established dependence between therapeutic effect and annual exacerbation rate, simplification of eradication therapy regardless severity of clinical semiotics.
1 tbl, 4 ex
FIELD: medicine; veterinary.
SUBSTANCE: antagonists of metabotropic glutamate receptor 5 (MGLUR5) are suggested to inhibit the transit relaxation of the inferior esophageal sphincter, as well as the corresponding method of treatment and/or prevention of related disorders. Particularly, such disorders include gastroesophageal reflux, gastroesophageal reflux disease, regurgitation, pulmonary disease, hypoplasia of organism, and asthma. The following antagonists of metabotropic glutamate receptor 5 are preferable: 2-methyl-6-(fenyl-etynyl) pyridine, hydrochloride 2- methyl-6-(fenyl-etynyl) pyridine, 3-[3-(5- fluoropyridine -2-il)-1,2,4-oxadiazol-5-il]-5-(metoxymethyl) benzonitrile, 3-fluor-5-[3-(5- fluoropyridine -2-il)-1,2,4- oxadiazol-5-il] benzonitrile.
EFFECT: compounds inhibited the pressure of inferior esophageal sphincter decreased by infusion pomp, in dogs.
26 cl, 4 tbl, 3 ex
SUBSTANCE: specimen consists of polyzones and thiamine bromide at a following relation of components (in mass fraction): polyzones - 80...60, thiamine bromide - 20...40.
EFFECT: specimen has a hyperactivity growth-stimulating effect and raises resistance of animals to sicknesses of a gastrointestinal tract.
FIELD: medicine, angiocardiosurgery, gastroenterology.
SUBSTANCE: the present innovation deals with endoscopic treatment of gastroduodenal ulcers in angiocardiosurgical patients. One should endoscopically apply gel containing 3%-aqueous solution of sodium carboxymethyl cellulose and 5%-oxymethyl uracil upon the ulcer. Single dosage corresponds 5-10 ml, the course - about 3-4 seances every 1-2 d. The innovation provides polycomponent impact of the mentioned medicinal preparation and, thus, shortened terms of pre-surgical preparatory procedures in angiocardiosurgical patients upon the main disease, the prevention of the development of its complicated forms.
EFFECT: higher efficiency of therapy.
SUBSTANCE: method involves detecting duodenum wall integrity disorders in performing endoscopic examination of duodenal ulcer after removing necrotic detritus from ulcer bottom. Available wall defect is subjected to endoscopic probing with catheter introducing water-soluble radiopaque solution through the probe and followed with fistulographic examination. The radiopaque solution being observed outside of duodenum, duodenal fistula or perforated ulcer are diagnosed.
EFFECT: high reliability of early stage diagnosis.
SUBSTANCE: method involves giving magnesium-sodium-hydrocarbonate mineral water of moderate mineralization degree at room temperature in the amount of 150-200 ml. 20-30 min later alternating electromagnetic field operating in low frequency bandwidth of 0.022 Hz-270 kHz is administered in scanning mode of 43 produced by Rematherp apparatus. The total treatment course is 8-10 procedures long.
EFFECT: enhanced effectiveness of treatment; stimulated reparative processes in esophageal mucous membrane.
FIELD: medicine; psychiatry.
SUBSTANCE: tranquilizers, antidepressants, homeopathic agents of sedative and antidepressant action. Autogenic training, rational, hypnosuggestive family and sexual psychotherapy are applied. Surface multi-needle acupuncture, transdermal electric stimulation of nerves, pressure point and deep massage of cervicocollar area, back, lumbosacral and gluteal region, abdomen and anterior chest are applied. Acupuncture, thermal and infrared light puncture to auricular and corporeal median points of heart, lungs, pericardium, liver, pancreatic gland, small and large intestine, triple heater, gallbladder, anterior and posterior median meridians is performed considering modifications detected by pulse and acupuncture diagnostics. Corporeal points are magnet laser punctured. Colour and musical therapy are applied.
EFFECT: reduced therapy time and prolonged remission.
FIELD: medicine; equipment.
SUBSTANCE: biologically active points are electrically stimulated. Sound musical signals effect on auditory analyser. Video information emotionally associated with musical composition effect on visual receptors. Electric stimulation is performed with pulse current at pulse duration - 3.3·10-4 S - pulse-repetition frequency changes within the range- 1÷2·103 Hz according to musical signal frequency. Stimulating pulse frequency is stable within stimulation procedure. Electric musical massager comprises electronic information reproducing unit designed to generate musical signal. Besides, it includes electroacoustic transducer designed to accept accompanying-sound signal and coetaneous stimulating electrodes. Electronic information reproducing unit is furnished with complementary function of video information reproducing. Massager also contains video transducer connected to electronic information reproducing unit and designed to accept video signal, and sound signal converter to stimulating impulses with stable amplitude. Impulses are converted at repetition frequency, assigning accompanying-sound signal frequency within the range 1 to 2000 Hz, and with frequency-time characteristics corresponding to frequency-time characteristics of neuromuscular structure biopotentials.
EFFECT: increased efficiency owing to biological adaptation correspondence of harmonic stimulating current characteristics and induced potentials of neuromuscular structure inervation activity.
2 cl, 1 tbl, 2 ex, 1 dwg
SUBSTANCE: invention refers to medicine, specifically to vertebrology and can be applied within complex therapy of severe compressive-vascular syndromes of vertebral column. It provides complete muscular relaxation of whole body by eans of intravenous anaesthesia, prescribed depending on the way patient feels, his age and clinical state - sodium hyopental or seduxen, or calipsol, or gamma hydroxy-butanoic acid. After loss of consciousness and complete relaxation, concerned vertebral parts are single-step corrected by single-step traction-pulse action on vertebral column followed by temporary fixation of concerned parts. After pain syndrome is lowered or decreased within one day after manipulation magnet-laser-light therapy is applied. Method provides sparing and safe effect on vertebral column owing to ideal relaxation of whole muscular system that makes it possible to perform single-step correction of all the vertebral parts at multisystem and combined injuries of vertebral-motor segment, reduction of treatment period, removal of pain dominant and reflex pathologic statico-dinamic stereotype in central nervous system and cerebral cortex.
EFFECT: sparing and safe effect on vertebral column, reduction of treatment period.
3 cl, 1 ex
FIELD: medicine; psychotherapy.
SUBSTANCE: psychodiagnostics begins with anamnestic data acquisition concerning examined person and his relatives, then vital events of every relative are analyzed with personal type, family relationship features and dynamics detection by integrated psychogenetic reconstruction method. Life condition factors of examined person and his relatives are analyzed. Assuming detected factors genus medical history is determined. Genus psycogenogram of examined person is made by schematic view of his family system with symbolic representation of sex difference, marital relationships, children existence, as well as indication of mental features and personal types of genus representatives of different generations. Mental state of examined person is determined for examination moment and personal mental features formation and potential pathologic deviations are forecasted in terms of condition that basic parameters of personal mental features and properties are inherited through generations from progenitor of the same sex by parent line of another sex. Basic principle for personal formation is parents' relations, and interpersonal attitudes formation is repeated in every generation mainly by relative of the same sex.
EFFECT: improved effectiveness of psychotherapeutic assistance.
2 ex, 3 dwg
SUBSTANCE: method involves acting upon sportsman with acoustic sound space produced by reciting poetry in hexameter or iambus rhythm.
EFFECT: enhanced effectiveness in increasing training productivity.
SUBSTANCE: method involves selecting acoustic reference images representing natural noise types causing comfortable feelings in patient in known functional states. Individual acoustic addressed image composed of natural noises as program saved on devices allowing recording and playing back sounds. Biological object selects those images, which are thought to be pleasant in current moment, from suggested acoustic images series. One of the images is transformed into electroacoustic one and human skin is treated via adapter during 10-50 min to reach required functional parameter values.
EFFECT: accelerated method for achieving comfortable state with initial functional state taken into account; activated general organism condition.
SUBSTANCE: method involves diagnosing diseases by measuring biologically active points parameters using R.Voll approach and comparing the results to reference values and selecting individual treatment course drugs by testing. Biologically active points values are measured in dynamic mode and the treatment course is adjusted with repeated treatment courses until reference control values are achieved. Measured values intervals are taken as reference normal values equal to 2 units. Values violating norm limits in any direction are divided into the first, the second and the third stage starting from norm interval boundary. Known color is assigned to each stage number. Representative points are additionally measured in each system increasing the number of biologically active points to 370. measured values magnitudes are recorded in table. The measured values are visualized with color assigned to given stage. Drugs are selected using their maximum repair, harmonization and stabilization capability criterion in selected points. The drugs are selected from nutriceutic phytopreparation group. When treating, hardware means are used like electric vibromassage devices. Psychocorrection is additionally applied.
EFFECT: timely detecting and treating abnormal states.
SUBSTANCE: method involves determining functional organism state on basis of pulse and acupuncture diagnosing data. Patient takes tranquilizers, antidepressants, neuroleptics, homeopathic drugs of sedative and spasmolytic activity. Autotraining, rational, hyposuggestive, family and sexual psychotherapy treatment is applied. Superficial multi-needle acupuncture, transcutaneous electric neurostimulation, point- and deep massage is applied to cervical collar zone, back, lumbosacral and gluteal zone alternated with deep abdominal massage and point massage of anterior chest wall. Scalp is massaged. Acupuncture, heat- and infrared light puncture is applied to auricular and corporal points. Point set selection depends on headache localization. Gallbladder, small intestine, urinary bladder, pancreas, stomach, large intestine, triple heater meridians, anterior and posterior middle meridians. Color and music therapy is applied.
EFFECT: enhanced effectiveness of treatment.
SUBSTANCE: in a child it is necessary to detect the level of anxiety according to the scale of apparent anxiety CMAS, calculate leukocytic formula, determine the content of monocytes, carry out a spontaneous NBT test. In 8 mo it is important to repeat medicinal therapy. On finishing therapy the same parameters should be determined. At normalizing the level of anxiety up to about 3-6 points, at considerable decrease in the values of the content of monocytes and spontaneous NBT test therapy should be considered to be the efficient one. At decreased level of anxiety up to the norm, but at maintaining high values of the content of monocytes and spontaneous NBT test - therapy should be considered to be the inefficient one. The innovation enables to detect the dynamics of the complex of valuable clinico-psychopathological and immunological values that illustrate the efficiency of therapy in children with emotional and behavioral disorders.
EFFECT: higher efficiency of therapy.
2 ex, 1 tbl
SUBSTANCE: exerciser has armchair with torsion muscle, hands and feet force perceptive parts, dynamometer for measuring of muscular stress, load mode change-over mechanism, converters for converting mechanical energy of muscular force to sound signal of respective tone and sound volume and to light signal of respective color and brightness, synchronizer for simultaneous generation of sound and light signals, loudspeaker for reproducing of sound signal, and screen for reproducing of light signal. Sound signals correspond to "do", "re", "mi", "fa", "sol", "la", "si" notes and light signals correspond to red, orange, yellow, green, blue, dark blue and violet colors.
EFFECT: increased exercising efficiency.
FIELD: medicine; ophthalmology.
SUBSTANCE: acyclovir solution is injected under posterior fornix of conjunctiva in dosage 1.0 ml 1 time a day during 10 days. It is also used for intravenous drop-by-drop introduction in dosage 250 mg 3 times a day during 5-7 days. At the same time for immune-modulating purposes immunomax is intramuscularly injected in dosage 1.0 ml 1 time a day on the 1,2, 3, 8, 9, 10 days of treatment.
EFFECT: increased therapeutic effect; reduced treatment time and relapse prevention.