Medicine of antioxidant action
FIELD: medicine; pharmaceutical industry.
SUBSTANCE: medicine of antioxidant action is powder extract of aerial dropwort (Filipendula vulgaris Moech), made by standard extraction of aerial dropwort under specified conditions. Powder extract contains specified number of flavonoids and coumarins as active agents.
EFFECT: improved antioxidant action.
The invention relates to medicine, specifically to clinical pharmacology, and can be used for pharmacological correction of free radical pathology.
Well-known medicinal product with antioxidant action, dihydroquercetin, vitamins (ascorbic acid, tocopherol acetate, retinol acetate) and their analogues, other [1, 2]. Therapeutic efficacy (the ability to inhibit free radical oxidation at different stages of the process) of these antioxidants in the treatment of free radical pathology is not high enough.
Closest to predlagamom is a drug with antioxidant effect, obtained from the aerial parts of meadowsweet, containing flavonoids .
A new technical task is the expansion of the means of plant origin with a more pronounced antioxidant effect.
The task to solve a new tool that has an antioxidant effect, representing the dry extract of the aerial parts of Filipendula ordinary (Filipendula vulgaris Moech)obtained in 95% ethanol and containing not less than 2.2% flavonoids and 0.54% of coumarins.
Meadowsweet ordinary (Filipendula vulgaris Moech) is a perennial herbaceous plant that grows in steppe dry meadows, rocky slopes, ratrie the different forests of the South of the European part of Russia, Western and parts of Eastern Siberia, in the Altai [4, 5]. In folk medicine the plant is used as astringent, anti-inflammatory, wound healing and hemostatic agent. Rhizomes and roots meadowsweet common part of the collection of recipes Minstance, which is used as a symptomatic remedy for bladder papillomatosis and antacid gastritis [6, 8]. As a result of studying the chemical composition of the aerial parts of the plant using chemical reactions, chromatography in thin layer and paper, spectral methods, we detected the presence of the following groups of biologically active substances: flavonoids (luteolin, apigenin, quercetin, dihydroquercetin, avikulyarin, isoquercitrin) - 1,72±0,09%, in terms of quercetin; coumarins (coumarin, umbelliferone); phenol carbonic acids (Gallic, gentisic); tannins hydrolyzable groups in the number of 3.23±0,36%; triterpene saponins, polysaccharides composed of D-glucose, D-galactose and D-glucuronic acid - 1,47±0,014%; carotenoids and amino acids.
Antioxidant action of the extracts of the herb are not described in literature. The development of a new tool, has an antioxidant effect, is made possible through the identification of experimentally its new properties and composition, namely the ability to normalize disbale the relationship with systems of free radical oxidation and total antioxidant activity in the body due to the antioxidant action contained complex of biologically active substances, including flavonoids and coumarins.
As shown by experimental studies, our proposed tool - extract of Filipendula vulgaris, obtained in 95% ethanol, has superior antioxidant action infusion of flowers of meadowsweet. In addition, our studies revealed that the extract of Filipendula vulgaris, obtained in 95% ethanol, greater than for the proposed action is similar to the extract of meadowsweet. Thus, the use of the proposed tools will lead to an expanding Arsenal of antioxidant agents of plant origin used in clinical practice.
With this in mind you should consider the claimed solution meets the criterion of "significant differences".
A new kind of activity identified on the basis of the conducted research and experimental research. The study was subjected to aqueous and aqueous-ethanolic extracts(40%, 70%, 95%) aerial parts meadowsweet common. Standardization of the extracts was carried out according to the content of flavonoids  and coumarins  is the most important group of active complex aerial parts meadowsweet ordinary.
Investigated the antioxidant effects of extracts from the aerial parts (stems, leaves, flowers) Filipendula vulgaris, obtained in the following ways :
Example . The aboveground part (stems, leaves, flowers) meadowsweet common Filipendula vulgaris Moech collected during the flowering and dried air way, pulverized and sieved through a sieve with the hole diameter of 2 mm (moisture content of 7.4%). 50 g of crushed raw material is placed in a glass flask, pour 500 ml of purified water and heated at a temperature of 85°With water bath under reflux for 30 minutes the resulting extract is filtered, raw press. The extract is evaporated under vacuum at a temperature not above 60°With dryness. Output (table 1) dry extract of 7.25 g, which is 14,50% by weight of the feedstock (water extract). The content of flavonoids in dry extract amounted to 0.56%, coumarins - 0,16%.
Example 2. The aboveground part (stems, leaves, flowers) meadowsweet common Filipendula vulgaris Moech collected during the flowering and dried air way, pulverized and sieved through a sieve with the hole diameter of 2 mm (moisture content of 7.4%). 50 g of crushed raw material is placed in a glass flask, pour 500 ml of 40% ethanol and heated at a temperature of 85°With water bath under reflux for 40 minutes, the Obtained extract was filtered, raw press. The extract is evaporated under vacuum at a temperature not above 60°With dryness. The yield of dry extract 8,71 g, which is 17,42% by weight of the feedstock (extract 40% ethanol). Soda is the content of flavonoids in dry extract was 1.65%, coumarins - 0,25%.
Example 3. The aboveground part (stems, leaves, flowers) meadowsweet common Filipendula vulgaris Moech collected during the flowering and dried air way, pulverized and sieved through a sieve with the hole diameter of 2 mm (moisture content of 7.4%). 50 g of crushed raw material is placed in a glass flask, pour 500 ml of 70% ethanol and heated at a temperature of 85°With water bath under reflux for 40 minutes, the Obtained extract was filtered, raw press. The extract is evaporated under vacuum at a temperature not above 60°With dryness. The yield of dry extract 11,35 g, which is 22,70% by weight of the feedstock (extract 70% ethanol). The content of flavonoids in dry extract was 1.72%, coumarins - 0,32%.
Example 4. The aboveground part (stems, leaves, flowers) meadowsweet common Filipendula vulgaris Moech collected during the flowering and dried air way, pulverized and sieved through a sieve with the hole diameter of 2 mm (moisture content of 7.4%). 50 g of crushed raw material is placed in the flask, pour 500 ml of 95% ethanol and heated at a temperature of 80°With water bath under reflux for 40 minutes, the Obtained extract was filtered, raw press. The extract is evaporated under vacuum at a temperature not above 60°With dryness. The yield of dry extract 8,30 g, which is 16,60% by weight of the feedstock (extract 95% of et is zero). The content of flavonoids in dry extract was 2.20%, coumarins - 0,54%.
Antioxidant activity of extracts of Filipendula ordinary was determined by cathodic voltammetry [11, 12]. Antioxidants with restorative nature, react with oxygen and its active radicals, which is reflected in the decrease in cathode current of oxygen reduction at a mercury film electrode in potential from 0 to - 0,6 Century
Experimental studies were performed on serial voltammetric analyzer TA-2 ("Technogenetic" Tomsk). Electrochemical studies were carried out in three-electrode cell with the working of the mercury-film electrode, the reference electrode is silver chloride and auxiliary glassy carbon. As a background electrolyte (chosen experimentally) used phosphate buffer pH 6,86 (10 ml). The volume of the aliquot of the sample (C=0.01 g/ml) was 0.1 ml, respectively, the concentration of the sample in the cell - 1·10-4g/ml electrochemical cell used glass cups with a capacity of 20 cm3. The stirring solution was performed using a magnetic stirrer M-25 for 10 s, followed by soothing for 20 sec. For the variation of oxygen concentration in the solution until its complete removal used the nitrogen supplied in RA is creative under pressure through the gas tube. Shoot voltamperes cathodic oxygen reduction in constant-current mode was carried out under the following conditions: scan rate of the potential of 30 mV/s, the range of working potentials 0 - (minus 0.6)C. the Sensitivity of the device was varied in the range 0.4-4 Áa.
Reportedly built the dependence of the relative change of the limiting current of oxygen reduction from time process in the presence of the sample. On the slope of the tangent to the first plot this curve was calculated kinetic criterion To (Ámol/l·min), which reflects the amount of unreacted sample oxygen forms, resulting in the efficiency of interaction of the extract with oxygen radicals, and is determined by the formula:
where Co2the oxygen concentration in the original solution without the sample, is equal to its solubility in an appropriate solvent under normal conditions, Ámol/l;
Ii- the current value of the limiting current of oxygen reduction, MCA;
Ibeg- the value of the limiting current of oxygen reduction in the absence of a sample in solution, MCA;
T - time of the process, minutes
Periodic monitoring of the oxygen content in the solution (Co2) was carried out with help from slobodnog sensor "MAYOR-LIVRO" (Poland).
As Comparators used standard antioxidants - dihydroquercetin (C=0.01 g/ml) and ascorbic acid (C=0.01 g/ml).
The data obtained in the experiment were processed using the program Statistica 5.0.
It was established that the extracts of aerial parts of Filipendula ordinary exhibited antioxidant activity in relation to the process of electroreduction of oxygen, i.e. all samples interact with active oxygen forms. The use of aqueous-ethanolic extracts helps to increase the studied activity. The results of the experiment showed that the strong antioxidant effect has extract of Filipendula vulgaris, obtained in 95% ethanol. Extraction with 95% ethanol aerial parts of the plant significantly increases the antioxidant effect of the target product at the expense of the most complete extraction of biologically active substances (flavonoids, coumarins, phenol carbonic acids, and others), containing the largest number of free phenolic hydroxyl. The decrease in the concentration of ethanol in the extraction of raw materials meadowsweet from 70% to 0% is associated with changes in a unique ratio of biologically active substances. The results of the studies conducted showed that the antioxidant activity of the extract of the aerial parts (stems, Lis the article, flowers of Filipendula vulgaris, obtained in 95% ethanol (0,928±0,034 Ámol/l·min), exceeds the extract of meadowsweet (0,780±0,050 Ámol/l·min) and significantly superior to infusion of flowers of meadowsweet (0,404±0,023 Ámol/l·min), due to the specific chemical structure of the constituent phenolic compounds (flavonoids, phenol carbonic acids, coumarins and other) and their quantitative content. Last, having a hydroxyl with mobile hydrogen atoms, neutralize the gidroperekisi polyene fatty acids, converting them into non-toxic hydroxy acids. Lipophilic phenolic compounds are embedded in the cell membrane and inhibit the formation of primary and secondary products of lipoperoxidation.
The positive effect achieved through the use of as a source of funds to provide antioxidant protection, dry extract of the aerial parts of Filipendula vulgaris, obtained in 95% ethanol, which expanded the Arsenal of drugs of plant origin with antioxidant effect.
|Weight and yield of extracts of aerial parts of Filipendula ordinary|
|Extract||Weight g||Output %|
|Extract 40% ethanol||8,71±0,15||17,42±0,03|
|Extract 70% ethanol||11,35±0,25||22,70±0,05|
|Extract 95% ethanol||8,30±0,11||16,60±0,01|
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Means, having an antioxidant effect, which represents the dry extract of the aerial parts of meadowsweet obyknovenny the CSO (Filipendula vulgaris Moech), obtained by extraction of the aerial parts of Filipendula ordinary 95% ethanol at the ratio of raw material to the extractant 1:10, with a dry extract contains 2.2% flavonoids and 0.54% of coumarins as active substances.
SUBSTANCE: method relates to approach of treatment chronic obstructive pulmonary disease (COPD), which includes basic therapy with additional administration of 250 mg oral mexidole BID for 30 days, as immunomodulator. The advantage of this method is recovering therapy in patients with COPD to normalize their immune status with use of effective and affordable medicine.
EFFECT: rate and length of exacerbation are decreased, while remission is extended.
6 tbl, 1 ex
FIELD: organic chemistry, medicine, neurology, pharmacy.
SUBSTANCE: invention relates to novel hydrogenated pyrrolo[4,3-b]indoles of the general formula (1): , their racemates, optical isomers, geometric isomers, pharmaceutically acceptable salts and/or hydrates that can be used, for example, in treatment and prophylaxis of different neurodegenerative diseases, such as Alzheimer's syndrome. In the general formula (1): a dotted line with accompanying unbroken line represents ordinary or double bond; R1 and R2 represent independently of one another substitutes of amino group chosen from hydrogen atom, possibly substituted (C1-C6)-alkyl substituted possibly with aryl, possibly substituted phenyl, possibly substituted carbonylamino or thiocarbonylamino group, substituted acyl, possibly substituted aryl sulfonate wherein substituted in indicated R1 and R2 are chosen from (C1-C6)-alkyl, halogen atoms, nitro, carboxy, alkoxy group, aryl; R1 n represents one or some similar or different substituted of cyclic system chosen from hydrogen atom, alkyl, aryl, cyano group, halogen atom, 5-6-membered nitrogen-containing heteroaryl. Also, invention relates to methods for synthesis of these compounds, pharmaceutical compositions and their using, and to using compounds in libraries with their using.
EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions, improved methods of synthesis.
20 cl, 2 tbl, 12 ex
FIELD: medicine, oral surgery.
SUBSTANCE: before surgical interference one should intravenously once inject by drops 0.03%-sodium hypochlorite solution at 1:40 against the volume of a patient's circulating blood. In 2 h one should intravenously once by drops inject rexod preparation at 16 mg. Then comes surgical interference in the course of which one should additionally carry out sanitation with 0.06%-sodium hypochlorite solution. In post-surgical period for 2 d after interference it is necessary to inject the same quantity of 0.03%-sodium hypochlorite solution. Rexod should be injected during the 1st d after operation at the same dosage, and during the next 3 d - per 8 mg. Additionally, locally during the 1st phase of wound process one should treat purulent wound with 0.06%-sodium hypochlorite solution, During the 2nd phase of wound process till applying early secondary sutures one should apply "Soderm" ointment onto the wound, and in the 3d phase - "Contractubex" gel onto cicatricial tissue. The innovation enables to avoid the progress of inflammatory process and shorten terms of therapy due to combined general and local impact of preparations being of detoxication and antioxidant action.
EFFECT: higher efficiency of therapy.
FIELD: biology, medicine, organic chemistry.
SUBSTANCE: invention proposes compound of the general formula (I): wherein A means effector group; L means a linker link; B represents Skulachev-ion Sk or charged hydrophobic peptide. Compound can be used in preparing a pharmaceutical composition for target (directed) delivery of active substances in mitochondria carried out by electrochemical potential of hydrogen ions into mitochondria. Also, invention can be useful in treatment of diseases and states associated with disturbance of normal function of mitochondria, in particular, diseases associated with increased formation of free radicals and active forms of oxygen. The claimed invention owing to directed accumulation of biologically active substance in mitochondria provides enhancing the effectiveness of substance, to decrease total dose, probability and strength of adverse effects.
EFFECT: improved and valuable properties of method and pharmaceutical composition.
26 cl, 14 dwg, 16 ex
FIELD: organic chemistry, chemical technology, medicine, pharmacy.
SUBSTANCE: invention relates to novel hydrogenated azepino[4,3-b]indoles of the general formula (1): , their racemates, optical isomers, geometric isomers and their pharmaceutically acceptable salts and/or hydrates. In the general formula (1) a dotted line with accompanying unbroken line represents a simple or double bond; R1 and R2 represent independently of one another substitutes of amino-group chosen from hydrogen atom, possibly substituted (C1-C8)-alkyl possibly substituted with aryl, 5-6-membered azaheterocyclyl, (C1-C8)-alkoxycarbonyl, possibly substituted phenyl, possibly substituted carbonylamino- or thiocarbonylamino-group, substituted acyl, (C1-C8)-alkylsulfonyl, possibly substituted arylsulfonyl and wherein substitutes in indicated R1 and R2 are chosen independently from (C1-C8)-alkyl, halogen atoms, nitro-, carboxy-, alkoxy-group, aryl; Ri n represents one or some similar or different substitutes of cyclic system chosen from hydrogen atom, (C1-C8)-alkyl, (C6-C10)-aryl, halogen atom, 5-6-membered azaheterocyclyl. Also, invention relates to methods for synthesis of these compounds, their using and pharmaceutical composition and libraries of compounds. Synthesized compounds possess neuroprotective, cognitive-stimulating and anti-histaminic properties and can be used in treatment of different neurological disorders, allergic and autoimmune diseases, for example, for memory improvement.
EFFECT: valuable medicinal and biological properties of compounds and pharmaceutical composition, improved method of synthesis.
25 cl, 2 tbl, 12 ex
FIELD: pharmaceutical industry and technology.
SUBSTANCE: invention relates to a method for preparing agent possessing antioxidant activity, in particular, to a method for preparing extract possessing antioxidant activity from cultivated grape (Vitis vinifera L.) compound fruit racemes. Matured cultivated grape compound fruits are dried and milled under the definite conditions, the raw is extracted twice with ethyl alcohol at room temperature in the definite ratio raw to extractant. Then the prepared extract id evaporated, condensed extract is homogenized repeatedly and dried. Then for separation of lipophilic compounds extract is treated with a benzine solvent of sort "Nefras" at heating to boiling and at stirring, and for separation of water-soluble component extract is treated with water under definite conditions, suspension is filtered and the obtained deposit is dried. Above described method provides preparing extract showing the enhanced content of polyphenols.
EFFECT: improved preparing method.
3 cl, 3 tbl
FIELD: pharmaceutical industry.
SUBSTANCE: method comprises washing sea-buckthorn (hippophae rhamnoides L.) seeds with water, drying of washed seeds, grinding of dried seeds into powder having specified particle size, extraction of ground dried seeds with methanol, filtration of resulting extract to separate from solids, distillation of filtered extract in vacuum evaporator, and drying of concentrated crude extract to obtain fraction showing antibacterial and antioxidant activity.
EFFECT: increased antibacterial and antioxidant activities.
9 cl, 6 ex
FIELD: medicine, pharmaceutical industry, phytotherapy, pharmacy.
SUBSTANCE: invention proposes a hepatoprotective agent showing antioxidant activity, in particular, to using a plant dropwort (Filipendula ulmaria (L.) Maxim.) above-ground part as a hepatoprotective agent possessing the antioxidant activity. Method for preparing a hepatoprotective agent possessing the antioxidant activity involves extraction of vegetable raw with ethanol in percolator devices battery wherein dropwort (Filipendula ulmaria (L.) Maxim.) above-ground part is subjected for extraction under definite conditions. Extract possessing the hepatoprotective effect prepared by above describes method possesses the enhanced antioxidant activity.
EFFECT: valuable medicinal property of agent, improved prepared method.
3 cl, 5 tbl, 4 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to biologically active substances displaying perspective using medicine, veterinary science, cosmetics and dairy industry. Agent comprises polyoxyarylene ester and hydroquinone in their ratio from 83:17 to 5:95, respectively. Agent comprises 2-(1-oxy-4-hydroxyphenylene)benzoquinone or 4-hydroxyphenylene-2,4-dioxybenzene as a polyoxyarylene ester. Method for preparing agent involves mixing polyoxyarylene ester with hydroquinone and wearing the prepared mixture up to formation of the uniform mass. Invention provides creature of a novel agent of the broad spectrum of effect, namely: antioxidant, antihypoxic, antitumor, radioprotective, immunostimulating and biocide effects.
EFFECT: valuable properties of agent.
7 cl, 20 tbl, 16 ex
FIELD: medicine, surgery.
SUBSTANCE: on the 1st d after operation a patient should be injected with mexidol intravenously by drops at the dosage of 300 mg, during the next 2 d mexidol should be injected intramuscularly twice daily at the dosage of 200 mg. Moreover, during 10 d after operation a patient should be perorally introduced with ADP-37 preparation a the dosage of 6 capsules daily and during 5 d one should affect the wound with impulse magnetic field at about 0.5-1.0 Tl intensity through Dalcex-trypsin filter cloth impregnated with 0.01%-serotonin solution, once daily. The innovation enables to accelerate the terms of wound healing up to 6-7 d and avoid therapy-induced complications.
EFFECT: higher efficiency of therapy.
FIELD: medicine; pharmacology.
SUBSTANCE: application of hederagenine 3-O- α -L-rhamnopyranosyle(1→2)-[b-D-glucopyranosyle(1→4)]-α -L-arabinopyranosyde or containing extract Pulsatillae radix and application of water-soluble fraction of Pulsatillae radix extract containing hederagenine 3-O- α -L- rhamnopyranosyle(1→2)-[b-D- glucopyranosyle(1→4)]- α -L-arabinopyranosyde as a therapeutic agent for solid tumours.
EFFECT: large-scale inhibition of tumour increase on solid tumours cells; relatively low toxicity; decrease of side effects of well-known antitumour agents.
8 cl, 3 ex, 3 tbl
SUBSTANCE: vegetable raw is extracted, extract is mixed with vaseline and anhydrous lanoline. As a preliminary vegetable raw - white bryony roots - are crushed for fractions not more than 3 mm, defatted with mixture chloroform - ethanol (2:1) during 7-10 hours with further removal of dissolvent. Dried sovent cake is extracted with 70% ethanol at temperature 18-20°C, with proportions: extractor 1:2.0 during 144 hours in six diffusers; then at temperature 50-55°C vaseline and anhydrous lanoline are melted proportionally 85:10, mixture is cooled up to temperature 25-30°C; this mixture is combined with 5 portions of white bryony roots liquid extract.
EFFECT: drug without irritant odor.
2 tbl, 4 dwg, 8 ex
FIELD: medicine; medicine industry.
SUBSTANCE: laminaria powder with higher iodine content 0.2-0.35% is extracted from water at 89-90°C, mass proportion of laminaria powder-water is 1:3-1:5 during 120-180 minutes of mixing, mixture filtrating and combining received filtrate with food laminaria powder for pasty mass. This mass is dried until water content reaches 7-10%, dried product is crushed for fractions not more 120 mc.
EFFECT: iodine content product.
2 cl, 4 ex
FIELD: medicine; pharmacology.
SUBSTANCE: ointment for burns, dermatoses treatment and wound healing contains turpentine, beeswax, sea-buckthorn oil, cow's butter, pig's fat and biologically active substance selected from: aloe extract, plantain extract, beggars-ticks extract, rosehip extract, St. John's wort oil, linseed oil, calendula oil, bur oil, camomile oil, or propolis.
EFFECT: stimulating effect on regenerative processes in connective tissues and epithelium.
SUBSTANCE: invention relates to new compounds of the formula (1a) or its pharmaceutically acceptable salt, esters or imides where A is a thiophenyl group containing, probably, substitution, the thiophenyl group A containing, probably, substitution with one or several groups as follows: alkyl, halo or arylalkyl, Y is O, S or NR2 where R2 is hydrogen or alkyl group containing 1 to 6 carbon atoms, and R1 is an non-ramified alkyl group containing 6 to 25 carbon atoms, ramified alkyl group containing 6 to 25 carbon atoms, aryl alkyl group where the alkyl group contains 2 to 25 carbon atoms or phenyl group containing substitution with one or several groups as follows: phenyloxy, phenylthio, SO2-phenyl, alkylphenyl, CO-phenyl, CONR16- phenyl, NR16CO-phenyl or NR16 -phenyl containing, probably, substitution where R16 is hydrogen or alkyl group containing 1 to 4 carbon atoms, the groups phenyloxy, phenylthio, SO2-phenyl, alkylphenyl, CO-phenyl, CONR-phenyl or NR-phenyl containing, probably, substitution with one or several groups as follows: halo, alkyl, alkylhalo or phenyl group containing substitution with one or several groups or alkyl groups provided the above compound is not 5-methyl-2-(4-metoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on, 6-amyl-2-(4-chlorophenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on or 6-amyl-2-(4-metoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on Invention also relates to method of obtaining compounds of the formula (Ia) or (IIa), to pharmaceutical compound and application, as well as cosmetic technique.
EFFECT: obtaining of new biologically active compounds and pharmaceutical compounds based on them.
27 cl, 4 ex, 1 tbl
FIELD: medicine; pharmacology.
SUBSTANCE: extract of the birch bark containing the specific amount of betulin is used in prevention and treatment of Parkinson's disease.
EFFECT: extract of birch bark is efficient for prevention and treatment of Parkinson's disease.
19 dwg, 7 tbl
FIELD: medicine; pharmacology.
SUBSTANCE: antiallergic agent is produced by toluene extraction of the birch bark and contains the active components such as betulin, lupeol and O-caffeate taken in particular quantities.
EFFECT: agent is efficient against allergy and doesn't reveal side effects.
11 tbl, 9 ex
FIELD: medicine; veterinary.
SUBSTANCE: homeopathic drug Lyarsin is used as a pharmaceutical agent. 0.7 mL of Lyarsin per head is administered intramuscularly to the animals suffering from hepatosis, at the first trimester of pregnancy, twice in 3 days.
EFFECT: method reduces number of stillborn puppies and increases brood per pupped dam.
3 tbl, 2 ex
SUBSTANCE: film dosage form sticking to mucous, containing at least on active substance from hemp. The form contains the polymeric matrix, which is used as a reservoir for the active substance and sticking to mucous. The form can have the multilayer structure. It can also contain the non-active ingredients, odorants or aromatisors. The film form is used in treatment of pain in such diseases as carcinomatosis, AIDS, trauma and other disorders.
EFFECT: invention provides better tolerance to administered substances and rapid onset of administered drug, simplifies administration procedures.
SUBSTANCE: therapeutic-cosmetic agent for the external use contains pantohematogen, water, polymeric gel-forming component, as well as dimethyl sulfoxide and water. The components are taken in particular quantitative ratio.
EFFECT: agent shows stable efficiency in treatment of osteoarthrosis and spinal osteochondrosis.
7 cl, 2 dwg
FIELD: medicine, oncology, amino acids.
SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.
EFFECT: valuable medicinal antitumor properties of preparation.
8 cl, 4 tbl, 2 dwg, 4 ex