Ointment for burns, dermatoses treatment and wound healing

FIELD: medicine; pharmacology.

SUBSTANCE: ointment for burns, dermatoses treatment and wound healing contains turpentine, beeswax, sea-buckthorn oil, cow's butter, pig's fat and biologically active substance selected from: aloe extract, plantain extract, beggars-ticks extract, rosehip extract, St. John's wort oil, linseed oil, calendula oil, bur oil, camomile oil, or propolis.

EFFECT: stimulating effect on regenerative processes in connective tissues and epithelium.

19 ex

 

The invention relates to pharmaceuticals and applies ointment for external use with biostimulating properties for the treatment of burns, skin diseases and wound healing, which can also be used in cosmetology.

Known ointment "Benin" for the treatment of purulent and infected wounds of various etiologies, including fir oil, propolis, pine resin, spermaceti and the fat penguin with a mass ratio of components 3-7: 0,5-1,5:0,5-1,5:1,5-2,5:7-15, respectively (patent RF №2058776, IPC 6 AC 9/06, publ. 27.04.96).

A disadvantage of the known ointment is the presence in the formulation known spermaceti ointment and fat penguin, accessibility and raw materials are limited.

Known ointment "Zwar" for the treatment of purulent and infected wounds of various etiologies, containing the following components, wt.%: pine resin (the resin of pine or spruce) - 7,0-8,0; beeswax - 6,7-7,3; butter - 6,5-7,5; vegetable oil - 6,5-7,5; fat interior (pork, or beef, or goose, or sheep) - 19,0-22,0; propolis - 0,5-1,0; bow-turnip - rest (RF patent N 2139708, IPC 6 AC 9/06, publ. 20.10.99).

A disadvantage of the known ointment is the lack of range of therapeutic actions and presence in the recipe inaccessible components.

The closest technical solution for the proposed solution is the ointment for the treatment of inflammatory and traumatic diseases is any musculoskeletal and peripheral nervous system, containing the oleoresin of pine or fir, beeswax, propolis and vegetable oil, mummy, fir oil and sea buckthorn oil in the following ratio, wt.%: the oleoresin of pine or fir - 5,0-15,0; beeswax - 5,0-15,0; propolis - 1,0-3,0; mummy - 0.1 to 0.3; oil fir - 1,0-4,0; sea buckthorn oil - 1,0-5,0; vegetable oil - the rest (RF Patent No. 2190389, IPC 7 AC 9/06, publ. 10.10.2002).

A disadvantage of the known ointment is the lack of range of therapeutic action is due to the low content in the ointment active ingredients. Known composition does not allow to maintain a high quality of ointment for a long time and is inconvenient in use because of poor fixation and uneven distribution on the skin surface.

The technical task to be solved by the invention is the creation of medicines of domestic production in the form of ointments, with a pronounced anti-inflammatory, antiviral and regenerating action with good fixation and a uniform distribution on the skin surface, easy to use with a pronounced and prolonged effect.

The technical problem is solved by the fact that the ointment for the treatment of burns, skin diseases and wound healing containing the resin, beeswax, sea buckthorn oil, according to the invention further includes fats is th basis containing butter and lard in the following ratio, wt.%:

Oleoresin5,0-15,0
Beeswax5,0-10,0
Butter10,0-20,0
Sea buckthorn oil5,0-10,0
LardRest

The ointment further includes biologically active substance in the amount of 3.0-5.0 wt.%, selected from the group of: aloe extract, plantain extract, propolis extract, series, rosehip extract, St. John's wort oil, linseed oil, calendula oil, burdock oil, chamomile oil.

Quantitative intervals of the ratio of components included in the composition of ointments, were determined experimentally, are optimal to ensure maximum effectiveness of the ointment. Deviation from the proposed ratio of components is impractical, as it decreases therapeutic effect.

Thus, the content of beeswax should be in the range of 5-10 wt.%. The increase of its content in excess of 10 wt.% and reduction of less than 5 wt.% leads to deterioration of ductility ointments, resulting in the inconvenience of using ointments.

The increase in the content of butter more than 20 wt.% results ointment liquid consistency, Rast the penitent on the surface of the skin, what prevents the establishment of maximum concentration ointment in the localization of burns or wounds, and reducing the amount of butter less than 10 wt.% leads to thickening of the ointment, which degrades the uniformity of its application to the affected area of the body.

The decrease in the number of sea-buckthorn oil below 5.0 wt.% reduce the effectiveness of this component in the composition of ointments, and the increase in the number of sea-buckthorn oil more than 10 wt.% results ointment liquid consistency, spreading over the surface of the skin, which also leads to the inconvenience of using ointments.

Increasing the amount of resin in the composition of ointments for more than 15 wt.% causes local irritation and results in pain sensation, and reducing the number of less than 5.0 wt.% reduces the effectiveness of the ointment.

Using the above extracts and oils of biologically active substances of aloe in concentrations below 3.0% does not have sufficient antibacterial activity, and the use concentrations, large 5,0%, may occur stratification ointment.

The goal is also due to the fact that the proposed ointment has a multifaceted action: antiseptic, necroticism, anti-inflammatory and wound-infused creams natural components with a wide range of b is logicheskie action.

The technical result is achieved when using the totality of the claimed essential features, is to increase the effectiveness of treatment. reduction of terms of treatment of the skin surface due to therapeutic effects of the components of the ointment, a good fixation on the surface and prolonged action, as well as the convenience and hygiene of applying the proposed ointment.

The components of the ointment each separately have a healing effect on the skin.

Lard has a calming and moisturizing the skin effect has long pork fat was used as a remedy for burns.

Similar properties also has butter, but in a more liquid consistency. Butter has a high immunobiological and antibacterial properties, it is rich in micro - and macroelements. Butter in its composition contains vital organic acids, and also contains large amounts of fat-soluble vitamins a, E, B1, B2, B6, C. the Inclusion of components in the ointment of butter to 20% (20,0 g per 100.0 g of ointment) gives ointment fine condition, thereby it is easily absorbed by the skin.

Beeswax helps to heal wounds and cracks, nourishes and strengthens the skin. The wax on the chemical nature similar to fats. In the composition of the wax are available alcohols and fatty acids which, as well as a large amount of vitamin A. the presence of the wax carotene and vitamin a makes it useful in the treatment of many skin diseases, retards the growth of some pathogens, has antibiotic action. In ointments beeswax facilitates the formation of emulsions and increases its stability, and due to its nature improves absorbing their property.

Oleoresin is a biologically active substance, reinforcing the regenerative processes of the connective tissue and skin. Pine resin (oleoresin) is obtained by tapping Mature stands. The healing properties of oleoresin of pine, spruce, fir and cedar has long been known and are widely used in medicine. The resin of coniferous trees evolutionary adapted to suppress the infection in the wound surfaces.

Sea buckthorn oil is the richest source of vitamin a, And also has a high content of vitamin e, sea Buckthorn oil has epithelizing effect, promotes the healing of wounds, cracks on hands and feet, resorption of scars, is used in thermal and chemical burns, frostbite and radiation skin lesions, as well as for treatment of various skin diseases: eczema, dermatitis, psoriasis. It also has analgesic, antiseptic, antioxidant, capillary properties.

Aloe today is softening, moisturizing and preventive anti-inflammatory action. Effect of aloe Vera is enhanced with vitamin E, an antioxidant, aloe gives ointment significant anti-inflammatory effect, it also has a bactericidal effect. Aloe Vera promotes the healing of wounds, is used to treat burns, frostbite and radiation lesions of the skin, used to treat dermatitis, ulcers, acne, boils and ulcers.

St. John's wort is known primarily as a medicinal plant because it contains hypericin, flavonoids hyperoside, rutin, quartzetine, essential oil, resinous substances, carotene; rich in vitamins C, PP, tannins. The St. John's wort oil has antibacterial properties, antiseptic action on infected wounds, pronounced astringent and antimicrobial action, promotes tissue regeneration, soothes irritated skin.

In calendula contains bitter substances, mucus (2,5%), organic acids, essential oils, beta-carotene, vitamin C, flavonoids, bioflavonoids, saponins, tannins, resins (over 3%), inulin. Calendula has anti-inflammatory, antiseptic, wound healing, antiseptic, analgesic action and is used to treat wounds, injuries, chronic inflammation, for protection from education about atbrivojusi scarring during wound healing when skin rashes, herpes, swelling caused by frostbite.

Linseed oil is obtained by hot pressing from the crushed seeds. The exceptional value of this oil is high in unsaturated fatty acids (linolenic, linoleic, oleic acid), which is more than in any known vegetable oils. The oil obtained by cold pressing at t=40-45°With, is a "living" product and retains all the useful biologically active substances, vitamins and phospholipids. Flaxseed oil promotes the healing of wounds and fractures, is used to treat burns and radiation lesions of the skin, soothes irritated skin. It contributes to a more rapid regeneration of damaged tissues.

Plantain has hemostatic, anti-inflammatory and bactericidal effects, which are bound to polysaccharides (mucilage, pectin, carotene and vitamin U. Inclusion ointment plantain extract accelerates the healing of wounds and fractures, soothes irritated skin.

Propolis is produced by bees. Propolis has antibacterial, antiviral, antifungal, anti-inflammatory, bio-stimulating, antiallergic, analgesic, dermatological effect. Amino acids, organic acids, antibiotic and tannins, balsams, essential oils, coal is water, mineral salts, vitamins, trace elements and other components in the composition of propolis, cause its diverse pharmacological properties. He shows antimicrobial activity against more than 100 species of bacteria, fungi, and viruses, has a positive effect on immunological reactivity human (Bruises A.F. Bee kit. M.: Physical culture and sport, 1995, p.100-101, 104-145) Propolis promotes healing, is used to treat burns and frostbite, soothes irritated skin, is used in folk medicine for the treatment of eczema, boils, psoriasis, erysipelas.

Burdock oil is easily absorbed into the skin and promote rapid penetration into the skin with vitamins a and E, has wound healing properties.

Chamomile contains essential oils and flavonoids and coumarin. Essential oil of chamomile has a disinfectant and anti-inflammatory properties due to presence of chamazulene, promotes healing of cracks on the hands and feet, helps with burns and frostbite, reduces allergic skin reaction.

The series contains essential oil, flavonoids, derivatives of cinnamic acid, tannins with a high content of fractions of polyphenols, polysaccharides, carotenoids, and coumarins, balcony. The combination of a series of flavonoids and soluble polysaccharides helps improve the s absorbability plant complex series and an increase in its activity. Flavonoid compounds string (flavones and balcony) possess bacteriostatic and insecticidal properties. Antimicrobial and anti-inflammatory properties of extracts of a series associated with tannins, which are dominated by simple structure polyphenols with strong antimicrobial properties. Expressed antimicrobial properties of a series connected, moreover, with a high content of manganese. The series promotes healing, soothes irritated skin, reduces allergic skin reaction, is used in folk medicine for the treatment of eczema, skin and acne, boils, psoriasis and dermatitis.

Rosehip extract to possess diverse pharmacological activity, mainly due to ascorbic acid, with restorative properties and promotes tissue regeneration. Rose promotes the healing of wounds, the scars are resolved soothes irritated skin, used to treat eczema, dermatitis, psoriasis and ulcers.

In the proposed fatty ointment base, for example, softens inflammation, sea buckthorn oil provides healing effect, oleoresin promotes accelerated healing.

Although individual components of the ointment, or a combination found in known therapeutic ointments such purpose,the claimed combination of ingredients and their ratio in the composition of ointments were not found. The inventive combination of the components, taken in experimentally selected, the optimal amount that achieves the claimed therapeutic effect. Other ratios taken components are not allow in the short term to achieve the desired therapeutic effect.

The invention is illustrated by the following examples of specific performance.

Example 1. Preparation of ointment

Heated to a liquid state and strained lard (650 g), butter (150 g) and beeswax (100 g) is mixed and add the turpentine pine (50 g). The resulting mixture was thoroughly stirred and heated to 120-130°C. the mixture is Then cooled to 70°and mixed with sea buckthorn oil (50 ml). After stirring until a homogeneous mass is obtained ointment when hot pour in the prepared container. The ointment is a homogeneous thick viscous mass with a pleasant smell. The ointment is non-toxic. The melting point of the obtained ointment - 50°C. the Ointment should be stored in dark, cool place at a temperature of storage - 0-15°C, protected from direct sunlight. Shelf life - 1 year without loss of original activity.

Example 2.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax to 5.0%; butter - 15,0%; sea buckthorn oil - 5,0%; aloe - 3,0%; pig is th fat - 62%.

Example 3.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax to 5.0%; butter - 15,0%; sea buckthorn oil to 5.0%; the plantain extract - 3,0%; pork fat - 62%.

Example 4.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax to 5.0%; butter - 15,0%; sea buckthorn oil to 5.0%; the extract of Bidens - 3,0%; pork fat - 62%.

Example 5.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: oleoresin is 13.0%; beeswax - 10,0%; butter - 15,0%; sea buckthorn oil to 8.0%; propolis - 5,0%; lard - 49%.

Example 6.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: oleoresin of 5.0%; beeswax to 8.0%; butter - 15,0%; sea buckthorn oil - 6,0%; rosehip extract - 4,0%; pork fat - 62%.

Example 7.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax to 5.0%; butter - 15,0%; sea buckthorn oil - 7,0%; St. John's wort oil - 3,0%; pork fat - 60%.

Example 8.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax to 5.0%; butter - 15,0%; sea buckthorn oil - 7,0%; calendula oil - 3,0%; pork fat - 60%.

Example 9.

Example 10.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 15,0%; beeswax - 10,0%; butter - 10,0%; sea buckthorn oil to 5.0%; burdock oil - 3,0%; pork fat - 57,0%.

Example 11.

The claimed ointment is prepared analogously to example 1 with the following composition, wt.%: resin - 10,0%; beeswax - 7,0%; butter - 20,0%; sea buckthorn oil - 10,0%; chamomile oil - 3,0%; lard - 50,0%.

The ointment is applied on the skin or sterile gauze napkins in the form of compresses, depending on the extent of damage. When applied to an open wound or burn the claimed ointment allows you to remove the dressing without damaging fragile epithelium, while changing the dressing is carried out until complete epithelialization.

Radiation burns and lesions ointment applied topically in the form of ointment bandages 1-2 times daily in a dose of 2-5 g in the treatment of 10-20 days.

In case of thermal burns and lesions ointment applied topically in the form of ointment bandages 1-2 times daily in a dose of 10-50 g (depending on the area affected) in the treatment 7-21 days.

Eczema, atopic dermatitis, keratoderma, ichthyosis declare the ointment is applied on the affected skin 2-3 times daily in a thin layer, rubbing E. the fingertips, light, circular motions.

For dry skin, deep and painful fractures of the hands and feet of the claimed ointment applied 3-4 times per day.

Contraindications to the use of an individual intolerance (Allergy).

Example 12.

Patient C., 23 years. Applied with thermal burns 3rd degree largest about 15 cm in diameter. For treatment was assigned ointment, prepared according to example 2. To the burn superimposed ointment bandage 3 times a day. Inflammation has stopped on the third day of using ointments. On the seventh day of treatment at the burn was formed smooth pink skin. Complete healing occurred after 20 days of treatment. On the burn scars and couplers were observed.

Example 13.

The patient And. - 35 years. Treated for psoriasis within one year different medications, including ointments: Ichthyol, sulfur-tar, salicylic, but a strong positive effect was not observed. To ensure assigned ointment, prepared according to example 5. 35 days completely disappeared papules with a diameter up to 2 cm, also resorbed "plaques" in their place, the skin acquired a pinkish color, itching disappeared. Allergies were not observed.

Example 14.

Patient L. - 10 years. The diagnosis of pyoderma. Lesions localized on the hands, neck and lower face. To ensure assigned ointment prigotovlenn the I example 11. The claimed ointment was applied to the lesions of the skin every day, 2 times a day. After 6 days had passed and epithelization of the affected areas of the skin.

Example 15.

Patient C. - 32, Filed a complaint on long nonhealing wounds, was observed redness of the skin with edema and infiltration with purulent offices. To ensure assigned ointment, prepared according to example 7. The claimed ointment was applied to the wound 2 times a day, and at night were imposed in the form of an ointment dressing. On the fourth day hyperemia and edema slept, the wound was cleansed from pus, infiltration decreased. On the fifth day began epithelialization and for the ninth day, the wounds have healed.

Example 16.

Sick So 40 years. He complained of cracks on the heels of the feet. To ensure assigned ointment, prepared according to example 9. The ointment was applied 4 times a day. After two or three days the cracks healed, the skin on heels of feet cleansed and became softer.

Example 17.

Patient S., 19 years. Diagnosis: tinea chin, the left half of the face and neck. Observed temperature increase. There are pustules in size from 2 to 5 mm in diameter with a pink-red inflammatory rim; small pain. To ensure assigned ointment, prepared according to example 3. The ointment was applied to the affected skin 2-3 times a day. On the 3rd day was observed drying the contents of pustules in brown cor is, after exclusion of which remained slight pigmentation and peeling. The fifth day of symptoms folliculitis fully cropped. It was recommended to continue the procedure lubrication with a frequency of 1-2 times per day. On 8-9th day of the manifestation of folliculitis and related symptoms completely resolved. The patient was in good condition.

Example. 18.

Patient L., 41. Admitted with complaints of itching and skin rashes. Diagnosis: allergic dermatitis. To ensure assigned ointment, prepared according to example 8. The ointment was applied to the affected skin 2 times a day. Already on day 5 showed a significant improvement of the skin: decreased itching the affected areas was noticeably pale. The duration of treatment was 14 days. When examining a patient on the 14th day of the treatment was that the condition was considerably improved, skin itching does not bother, restore skin elasticity.

Example 19.

Patient D. 28 years. He complained of a burning sensation, itching, rashes and pustules on the skin, has been suffering from eczema for six months. To ensure assigned ointment, prepared according to example 8. Were rubbing the ointment in a thin layer in the area adjacent to the affected skin areas 2 times a day. On the 3rd day decreased itching, burning, number of pustules, especially around the affected area, which also decreased. A day pustules, itching and burning was practically absent. Further infiltration ceased, size of the affected area decreased, and the ointment was creeping into areas that came out of the affected area. On the previously affected areas, especially in the periphery, began to be rejected brown, and then remained low pigmentation. On the 14th day of treatment was completed. The patient was in good condition.

Treatment of the claimed ointment in almost all cases passed with a positive result was observed acceleration of wound healing without complications and side effects. The use of the proposed ointment showed a stimulating effect of the ointment on the regenerative processes of the connective tissue and epithelium, indicating a biostimulating effect of ointments and confirmed by the shortening of the healing of wounds with good fixation and a uniform distribution on the skin surface and ease of use.

Ointment for the treatment of burns, skin diseases and wound healing containing the resin, beeswax, sea buckthorn oil, characterized in that it additionally contains butter and lard, as well as substances of plant origin selected from the group of: aloe extract, plantain extract, extract of Bidens, rosehip extract, St. John's wort oil, calendula oil, chamomile oil, linseed oil, burdock oil is or propolis in the following ratio of components, wt.%:

oleoresin5,0-15,0
beeswax5,0-10,0
butter10,0-20,0
sea buckthorn oil5,0-10,0
substances of plant
origin or propolis3,0-5,0
lardrest



 

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9 ex, 1 tbl

FIELD: medicine; chemical-pharmaceutical industry.

SUBSTANCE: method of pharmaceutical formulation making of ointment for herniation of intervertebral disks includes mixing of papain protein-degrading enzyme of activity 6000 units and distilled water at temperature 20°C until complete papain dissolution. Papain solution is added with premix of polyethyleneoxide of molecular weight 1500 Dalton and polyethyleneoxide of molecular weight 400 Dalton in proportions 1:2 respectively. Papain solution and mentioned polyethyleneoxides are mixed during 1 hour at temperature 37-39°C, mixture is added with dimethyl sulfoxide and mixed during 30 min.

EFFECT: decrease of rehabilitation period.

3 ex

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: invention represents a drug of the following composition, wt.-%: chondroitin sulfate, 1.0-10.0; sodium diclofenac, 1.0-10.0; dimethylsulfoxide, 5.0-25.0, and ointment base, the balance. Ointment base represents pentol, stearic acid, vaseline, lanolin and water, polymeric-base gel, or polyethylene oxides. Proposed drug possesses the combined effect.

EFFECT: improved and valuable medicinal properties of agent.

2 cl, 1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: described are injection compositions for administering of drug by implantation. Claimed composition contains low-molecular biodegradable biocompatible polymer, biocompatible water low-miscible solvent, which forms viscous gel with polymer and limits water absorption by implant, and pharmaceutical agent. Said solvent is selected from group containing aromatic alcohols, aromatic acid esters, aromatic ketones or mixture thereof. Gelled depot composition of present invention may be administered in mammalian body without surgery procedure and provides controlled release of pharmaceutical agent for about seven days.

EFFECT: new biodegradable depot compositions.

30 cl, 13 dwg, 3 tbl, 12 ex

FIELD: medicine.

SUBSTANCE: claimed liniment useful in therapy of wounds, bed sores, ulcers contains insecticide such as sapropel tar, xeroform, aerosil, castor oil in specific component ratio (mass %).

EFFECT: absence of tumorogenic effect, effective healing.

3 tbl

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an agent used in treatment of trophic ulcer. Proposed agent comprises anhydrous lanolin as an ointment base and active substance wherein the proposed agent comprises as an active substance nutrient medium-199 or nutrient medium RPMI-1640 in the ratio of ointment base and nutrient medium from 5:1 to 1:1. Also, invention relates to a method for treatment of trophic ulcer that involves applying the agent placed on napkin on wound surface. Agent containing anhydrous lanolin and nutrient medium is applied on wound surface cleared with boric acid solution for 2-3 days, After applying the agent is replaced some times per a day, and during carrying out the treatment course used agent comprises one of the following ratio of ointment base and nutrient medium (5:1, 4:1, 3:1, 2:1, 1:1), or their combination. Treatment begins using the agent with the minimal content of nutrient medium, and in case of retention of granulation and epitheliolysis processes the ratio of lanolin to nutrient medium is changed from 5:1 to 1:1. Proposed method and agent enhance effectiveness in treatment of trophic ulcers, decrease treatment period that results to decreasing loss by disability.

EFFECT: improved method of treatment, enhanced and valuable properties of agent.

2 cl, 2 tbl, 2 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to drugs as ointments used in treatment of wounds and ulcerous damages of skin tissue and mucosa envelopes. Proposed medicinal agent comprises active mixture of two medicinal substances represented by thiotrazoline and laevomycetinum taken in the ratio 4:1 or 2:1. Optimal variant of ointment containing thiotriazoline and laevomycetinum comprises 2 g of thiotriazoline and 0.5 g of laevomycetinum in 100 g of ointment. Using the proposed medicinal agent as ointment enhances its wound-healing effect significantly as compared with the known preparations.

EFFECT: enhanced effectiveness of agent.

5 tbl, 5 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a pharmaceutical composition used in treatment of burns. The composition comprises N-(β-hydroxyethyl)-4,6-dimethyldihydropyrimidon-2 (xymedone) and base-forming agents. As base-forming agents the composition comprises gel-forming agent representing biopolymer sodium salts, glycerol as a water-retaining agent taken in the amount 20 wt.-%, not less, stabilizing agent, preserving agent and distilled water. In addition to xymedone variants of the composition can comprise silver nitrate or silver nitrate and sodium sulfacyl, or laevomycetinum and succinic acid as an active substance. Tests showed high effectiveness of the proposed pharmaceutical composition satisfying all medico-biological requirements imposed to design of modern medicinal agents used in treatment of burns and wounds. Proposed pharmaceutical composition can be used as an agent showing highly effective regenerating, wound-healing and improving microcirculation properties in treatment of infected burned wound.

EFFECT: valuable medicinal properties of pharmaceutical composition.

9 cl, 2 tbl, 16 ex

FIELD: medicine, ophthalmology, pharmacy.

SUBSTANCE: invention proposes ophthalmic ointment containing ciprofloxacin hydrochloride monohydrate equivalent to the concentration 0.1-0.9% as a free base, preserving agent, for example nipagin or nipasol, and a sterile base consisting of vaseline melt of sort "for ophthalmic ointments" and anhydrous lanolin. Ophthalmic ointment is prepared by melting vaseline and anhydrous lanolin and step-by-step mixing milled ciprofloxacin hydrochloride and preserving agent with sterile base. Invention provides producing a sterile and stable ciprofloxacin-containing ophthalmic ointment used for local treatment of eye inflammatory diseases and of bacterial etiology.

EFFECT: improved preparing method, valuable medicinal properties of composition and ointment.

2 cl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of the formula (1a) or its pharmaceutically acceptable salt, esters or imides where A is a thiophenyl group containing, probably, substitution, the thiophenyl group A containing, probably, substitution with one or several groups as follows: alkyl, halo or arylalkyl, Y is O, S or NR2 where R2 is hydrogen or alkyl group containing 1 to 6 carbon atoms, and R1 is an non-ramified alkyl group containing 6 to 25 carbon atoms, ramified alkyl group containing 6 to 25 carbon atoms, aryl alkyl group where the alkyl group contains 2 to 25 carbon atoms or phenyl group containing substitution with one or several groups as follows: phenyloxy, phenylthio, SO2-phenyl, alkylphenyl, CO-phenyl, CONR16- phenyl, NR16CO-phenyl or NR16 -phenyl containing, probably, substitution where R16 is hydrogen or alkyl group containing 1 to 4 carbon atoms, the groups phenyloxy, phenylthio, SO2-phenyl, alkylphenyl, CO-phenyl, CONR-phenyl or NR-phenyl containing, probably, substitution with one or several groups as follows: halo, alkyl, alkylhalo or phenyl group containing substitution with one or several groups or alkyl groups provided the above compound is not 5-methyl-2-(4-metoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on, 6-amyl-2-(4-chlorophenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on or 6-amyl-2-(4-metoxyphenyl)amino-4H-thieno[2,3-d][1,3]oxazine-4-on Invention also relates to method of obtaining compounds of the formula (Ia) or (IIa), to pharmaceutical compound and application, as well as cosmetic technique.

EFFECT: obtaining of new biologically active compounds and pharmaceutical compounds based on them.

27 cl, 4 ex, 1 tbl

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