Suppository base

FIELD: medicine, pharmacology.

SUBSTANCE: suppository base consists of thickener alloy, hydrophilic substance, lipophilic substance and complex with polyethylene glycol received by mixing in polyethylene glycol with molecular mass 200-6000 Da, lipophilic and hydrophilic substances.

EFFECT: provides rapid absorption of pharmaceutical substance into blood flow.

4 cl, 3 tbl, 2 ex

 

The invention relates to medicine, in particular to drugs, and can be used in the manufacture of bases for suppositories rectal, urogenital or vaginal application.

From a wide range of bases known hydrophilic and lipophilic bases.

(EN 2102977, EN 2185817, EN 2114609, EN 2115412, EN 2150268, EN 2104690)

The objective of the invention is to create a universal framework for suppositories, ensuring the bioavailability of fat-soluble, water-soluble and sparingly soluble in fat or water substances, and obtaining high aggregately-resistant composition framework.

This object is achieved in that the base for suppositories consists of an alloy or mixture of three components: lipophilic substances, hydrophilic substances and complex of lipophilic and/or hydrophilic substances, pre-mixed in polyethylenglycol with a molecular mass of 200-6000 D, taken in the following ratio, wt.%:

- hydrophilic substance is 0.1 to 49,0

- complex of lipophilic and/or hydrophilic substances, pre-mixed in polyethylenglycol, - 0,1-50,0

- lipophilic substances - the rest.

As hydrophilic substances base according to the invention contains components selected from the group: medical gelatin, glycerin, sodium carbonate crystal, polyvinylpyrrolidone ISCO or weight, water-soluble derivatives of cellulose, cyclodextrins, herbal extracts, alcohols, agar-agar, carragenin, propylene glycols with a molecular mass of 200-6000, pemulen, polysaccharides and their derivatives, honey, protein components, acrylic acid and its derivatives, peptides, dextrans in an effective amount.

As lipophilic substances base according to the invention contains components selected from the group of natural and synthetic oils and fats and their derivatives, and fatty acids and their derivatives, lecithin in an effective amount.

The complex, which is the Foundation according to the invention consists of the above-mentioned hydrophilic and/or lipophilic substances selected from the group pre-mixed in polyethylenglycol with a molecular mass of 200-6000 D,

As a thickener base according to the invention, further comprises components selected from the group of natural resins, synthetic balms, wax, silica, chitosan, emulsifiers and phytosterols in the number of 1-18 wt.%.

The proposed generic framework creates the most favorable conditions for fusion in the human body, promotes rapid penetration of the medicinal substance in the blood and improves the processing properties of the basics. The proposed composition of the base is compatible with therapeutic substance and has a physiologically the Russian indifference, i.e. not interacting with any medicinal substance, or with the mucous membrane.

Example. To obtain bases for suppositories in the form of an alloy or mixed three components: lipophilic substances, hydrophilic substance and a complex of lipophilic and/or hydrophilic substances, pre-mixed in polyethylenglycol with a molecular mass of 200-6000 D, taken in the following ratio, wt.%:

- hydrophilic substance is 0.1 to 49,0

- complex of lipophilic and/or hydrophilic substances, pre-mixed in polyethylenglycol, - 0,1-50,0

- lipophilic substances - the rest.

As hydrophilic substances take components selected from the group: medical gelatin, glycerin, sodium carbonate crystal, polyvinylpyrrolidone low or medium molecular, water-soluble cellulose derivatives, cyclodextrins, herbal extracts, alcohols, agar-agar, carragenin, lecithin, propylene glycols with a molecular mass of 200-6000, pemulen, polysaccharides and their derivatives, honey, protein components, acrylic acid and its derivatives, peptides, dextrans in an effective amount.

As lipophilic substances take components selected from the group of natural and synthetic oils, fats and their derivatives, fatty acids and their derivatives, lecithin in an effective amount. For example, Vit is PAL, hydrogenated fats, animal fats, vegetable fats, cocoa butter, petrolatum, paraffin, lanolin, tallow type a, b, C, silicone oil, stearic acid, fish oil.

Get a set of substances by mixing the polyethylene glycol with molecular weight of 200-6000 D lipophilic and/or hydrophilic substances selected from the above groups and in the proper ratio.

Then mix the resulting complex with hydrophilic and lipophilic components selected from the above groups, to obtain a melt or mixture.

To thicken the mixture into the base enter the components selected from the group of natural resins, synthetic balms, wax, silica, chitosan and phytosterols in the number of 1-18 wt.%.

The resulting mixture or melt basics mixed with the drug and placed in sterile form. Ready suppositories Packed. Packaging depends on the basis and form of suppository.

Experiments were conducted for the preparation of bases for suppositories. The results are summarized in the tables.

Table 1
ComponentsThe amount in wt.%
Hydrophilic substances0,10,51,05,010,0 15,025,030,035,049,0
The complex of the hydrophilic substances, pre-mixed in polyethylenglycol50,035,020,010,05,03,53,01,50,50,1
Thickeners18,016,015,014,0to 12.09,07.05,03,01,0
Lipophilic substances31,948,564,071,073,072,565,063,561,5to 49.9
Total:100100100100100100100100100100

Table 2
ComponentsThe amount in wt.%
Hydrophilic substances0,10,51,05.010,015,025,030,035,00,49
The complex and the lipophilic substances, pre-mixed in polyethylenglycol50,035,020,010,05,03,53,01,50,80,1
Thickeners1,03,05,07,09,0to 12.014,015,016,018,0
Lipophilic substances:48,961,574,078,076,069,558,053,551,832,9
Total:100100100100100100100100100100

To illustrate the invention presents such examples.
1.Tallow45 wt.%
Complex
solid fat and PEG 20035 wt.%
Gelatin medical5 wt.%
Chitosan15 wt.%
(upon receipt of a complex solid fat with PEG were mixed in a volume ratio 1:2)
2.Glycerin17 wt.%
Complex
of glycerol and PEG 600043 wt.%
Cocoa butter32 wt.%
Wax8 wt.%
(upon receipt of the complex was mixed with glycerol PEG in a volume ratio 1:1).

Are also presented to illustrate examples of quantitative ratios of the components of the framework and the relevant physico-chemical properties of these bases JV.

3,0
Table 3

The quantitative ratio of the components of the framework for SP
ComponentsThe amount in wt.%
Hydrophilic substances0,10,51,05,010,015,025,030,035,00,49
The complex of lipophilic substances, pre-mixed in polyethylenglycol50,035,020,010,05,03,51,50,80,1
Thickeners1,03,05,07,09,0to 12.014,015,016,018,0
Lipophilic substances:48,961,574,078,076,069,558,053,551.832,9
No. basics12345678910
Total:100100100100100100100100100100

td align="center"> 36
Table 4

Physico-chemical properties of individual variants of the above bases suppositories
no songsAverage weight (g)Tmelting point(With°)Tcuring(With°)The full deformation, min
12,01±0,131255,02
21,99±0,12718,50
32,04±0,135286,47
42,02±0,136262,70
52,00±0,135323,15
62,02±0,1372918,50
71,99±0,1362617,20
81,97±0,131267,00
92,00±0,13327of 5.06
102,02±0,133264,39

As can be seen from these data bases do not lose the basic properties required for joint venture creation.

Below is evidence of the rapid melting of the JV in the body and, consequently, the release and absorption in the blood of the examples JV with paracetamol (dose 0.5 g) and dioksidin (0.02 g).

Used a model two-factor analysis of variance with repeated experiments. Optimization settings chose the concentration of free paracetamol and dioksidina for 50 and 60 minutes respectively. The release of substances studied the Ali method of equilibrium dialysis through a semipermeable membrane. Dialysis medium was phosphate-borate buffer solution with a pH of 7.8, which corresponds to the pH value of the mucous membrane of the rectum. The concentration of paracetamol and dioksidina samples dialysate was determined by extraction titration. When the experiment JV was melted on a water bath.

When the analysis of variance revealed approximation to the optimization settings (50 and 60 minutes): 83% of the dose of paracetamol and 92% of the dose dioksidina.

Study of the release and other drugs showed similar satisfactory results, which suggests that the proposed framework does not preclude the optimal dynamics of release of the drug from the JV and its revenues in the environment of the body, including blood.

The results of the experiments showed that the obtained universal base for suppositories provides the bioavailability of fat-soluble, water-soluble and sparingly soluble in fat or water substances, has elevated aggregately-resistant properties, quickly melted in the body, promotes rapid flow of medicinal substance in the blood that is compatible with therapeutic substance and has physiological indifference, i.e. not interacting with any medicinal substance, or with the mucous membrane.

The proposed framework tested on the experimental-industrial is m equipment. Increased aggregately-resistant properties of the basis improve the quality of suppositories and their appearance.

1. The basis for suppositories, characterized in that it consists of alloy thickener and these three components, as hydrophilic substances, lipophilic substances and complex with polyethylene glycol, previously obtained by mixing the polyethylene glycol molecular weight 200-6000 D lipophilic or hydrophilic substances, and these three components are taken in the following ratio, wt.%:

hydrophilic substances0.1 to 49,0
complex with polyethylene glycolof 0.1 to 50.0
lipophilic substancesthe rest of it.

2. The Foundation according to claim 1, characterized in that the hydrophilic substances it contains components selected from the group: medical gelatin, glycerin, sodium carbonate crystal, polyvinylpyrrolidone low or medium molecular, water-soluble cellulose derivatives, cyclodextrins, herbal extracts, alcohols, agar-agar, carragenin, propylene glycols with a molecular mass of 200-6000, pemulen, polysaccharides and their derivatives, honey, protein components, acrylic acid and its derivatives, peptides, dextrans.

3. The Foundation according to claim 1, characterized in that as the e lipophilic substances it contains the components, selected from the group of natural and synthetic oils, fats and their derivatives, fatty acids and their derivatives.

4. The Foundation according to claim 1, characterized in that as a thickener it contains components selected from the group of natural resins, synthetic balms, wax, silica, chitosan, emulsifiers and phytosterols in the number of 1-18 wt.%.



 

Same patents:
Suppository // 2322968

FIELD: medicine, pharmacology, pharmacy.

SUBSTANCE: invention proposes suppository containing 40% of drug, not above, and a base consisting of melt of a thickening agent, hydrophilic substance, lipophilic substance and complex with polyethylene glycol. Complex is prepared by mixing lipophilic or hydrophilic substances in polyethylene glycol of molecular mass 200-6000 Da. Proposed suppository provides rapid delivery of drug in blood.

EFFECT: improved and valuable medicinal and pharmaceutical properties of suppository.

19 cl, 3 tbl, 2 ex

FIELD: veterinary science.

SUBSTANCE: invention proposes a composition comprising the following agents, wt.-%: liposomal concentrate emulsion with antibiotic of aminoglycoside class, 28.5-29.8; mother milk, 1.5-2.8; propolis, 2.3-4.2; bee wax, 22.5-24.1; hydrogenated fat, 23.5-25.0; gelatin, 1.5-2.0, and glycerol as an emulsifier, the balance. Suppository based on the proposed composition possesses the prolonged effect, low toxicity and high effectiveness.

EFFECT: improved and valuable medicinal properties of composition.

2 tbl, 4 ex

Vaginal suppository // 2320319

FIELD: medicine, gynecology, pharmacy.

SUBSTANCE: invention relates to preparing vaginal suppositories containing laevomycetin and metronidazol as antibacterial components, pernisolon as an anti-inflammatory component, and cacao butter and lanolin as filling agents wherein these components are taken in the following ratio, g: laevomycetin, 0.25 ± 0.01; metronidazol, 0.25 ± 0.01; nystatin, 0.0625 ± 0.0025, or 250000 ± 10000 U; prednisolone, 0.003; cacao butter, 2 ± 0.2, and lanolin 0.05. Proposed suppository possesses the enhanced effectiveness against mixed infections of lower regions of female reproductive sphere and providing increasing remission period of disease.

EFFECT: improved and valuable medicinal properties of suppository, enhanced effectiveness of treatment.

1 tbl, 4 ex

FIELD: biotechnology, pharmacy.

SUBSTANCE: invention relates to creature of a interferon-base solution for injections and to recombinant strains of Escherichia coli (E. coli) and plasmids for its preparing. Invention proposes a novel recombinant multicopy plasmid DNA pSX50 that encodes synthesis of human leukocyte alpha-2b-interferon expression of that is under control of lactose and tryptophan promoters and transcription terminator. The strain E. coli SX50 as a producer of human recombinant leukocyte alpha-2b-interferon with productivity up to 0.901.0 g of alpha-2b interferon is obtained by transformation of the recipient strain E. coli BL21 cells with recombinant plasmid DNA pSX50. Method for preparing recombinant alpha-2b interferon is based on using the created recombinant strain E. coli SX50 and involving its submerged culturing on nutrient medium with decreased content of tryptophan and at continuous addition of nutrient substrates in the process of biosynthesis. The method involves mechanical destruction of microbial cells under high pressure, dissolving precipitated protein in the concentrated solution of guanidine hydrochloride followed by renaturation of interferon in physiological buffer solutions in the presence of chaotropic agents and its purification using three-step chromatography purification of interferon on resins of type Chelating Sepharose Fast Flow immobilized with Cu2+ ions, ion-exchange chromatography on ion-exchange resins of type CM Sepharose Fast Flow and gel-filtration chromatography on resins of type Superdex-75. Three-step chromatography purification of interferon provides preparing interferon substance of purity above 98% by data of electrophoresis under reducing and non-reducing conditions, and above 95% by data RF HPLC, and this interferon substance doesn't contain pyrogenes (LAL-test). The yield of the end product is 400 mg from 1 l of cultural medium, not less. Invention provides enhancing yield of interferon and stability of its solution.

EFFECT: improved preparing method of interferon.

12 cl, 5 tbl, 6 dwg, 2 ex

FIELD: medicine, gynecology, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to development of vaginal suppository used for dilation of uterus cervix. Agent for dilation of uterus cervix is made as vaginal suppository and comprises Japanese or sugary laminaria micronized powder of particles size 200 mmc, not above, and in the ratio of active substance to suppository base = 1:1 and wherein Vitepsol H15 or Supacir are used as suppository base. Suppository is used in complex therapy for dilation of uterus cervix or in carrying out monotherapy and represents safety and effective method for dilation of uterus cervix.

EFFECT: improved and valuable medicinal properties of agent.

4 ex

Antibacterial agent // 2318523

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an antibacterial agent as a suppository containing iodine and designated for treatment of inflammatory diseases of female genital region. Agent prepared as a suppository and containing iodine as an active substance and a filling agent comprises active substance as a complex of iodine-DMSO (dimethylsulfoxide) taken in the ratio = 1:(1-10) wherein it contains a fat-soluble base as a filling agent and wherein the content of iodine is 10 mg. Proposed suppository shows broad spectrum of antibacterial effect and without adverse effect. Active substance penetrates into deep tissues and shows selective effect on microorganisms. The claimed agent is suitable for using and it doesn't pollute skin and dress.

EFFECT: improved and valuable properties of agent.

5 cl, 2 tbl, 5 ex

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to suppository used in treatment of genital condylomae and neoplastic diseases of reproductive organs. Agent for treatment of genital condylomae and neoplastic diseases of reproductive organs as a suppository comprises metindol (3,3'-diindolylmethane) as an active component, lipophilic base containing solid confectionary fat, polyvinylpyrrolidone and butylhydroxyanisole taken in the definite ratio. Proposed agent promotes to effective treatment of genital condylomae and neoplastic diseases of reproductive organs.

EFFECT: valuable medicinal properties of suppository.

2 cl, 4 dwg, 1 tbl, 5 ex

Anti-viral agent // 2316320

FIELD: pharmaceutical industry, in particular agents for viral disease treatment including HIV infection (AIDS and HIV-associated diseases).

SUBSTANCE: claimed agent in form of suppository contains per one 2 g suppository Fullevir (fullerenopolyaminocaproic acid sodium salt) 20 mg as active ingredient and ancillary substances such as propylene glycol 200 mg and balance: Vitepsol.

EFFECT: effective agent having no adverse influence on peripheral blood and body systems.

FIELD: pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to producing interferon-containing suppositories. Interferon-containing suppository comprises a fatty base, emulsifier and human lyophilized interferon purified from low-molecular and high-molecular components of the definite antiviral activity. Mixture of mono-, di- and triglycerides and saturated fatty acids from coconut oil and palm oil of sort "Vitepsol" H-15 and W-35 taken in equal ratio are used as a fatty base. Distilled monoglycerides taken in the definite ratio are used as an emulsifier. Above describes suppositories retain specific activity and effectiveness in treatment of viral and bacterial diseases for a long time and show stability against mechanical effects.

EFFECT: improved and valuable properties of suppository.

1 tbl, 1 ex

FIELD: chemical-and pharmaceutical industry.

SUBSTANCE: claimed agent contains DNA sodium salt isolated from bovine testis and is useful in peroral application in form of powder, tablets, pellets, and capsules for treatment and prophylaxis of anemia, secondary immunodeficit conditions and as bracing agent. Agent may additionally contains biologically active components and filler.

EFFECT: effective and convenient agent having antianemic, immunomodulating and adaptogenic actions.

3 cl, 3 ex, 6 tbl

FIELD: chemical and pharmaceutical industry.

SUBSTANCE: the present innovation deals with creating medicinal preparations of plant origin and could be applied for treating functional constipations and affected biorhythm of defecation. It is suggested to apply either dry aqueous or aqueous-alcoholic extract of horse chestnut seeds of Aesculus species to prepare curative-prophylactic preparation in case of constipation and affected biorhythm of defecation. The suggested preparation should be applied in the form of powder, tablets or suppositories. Pharmaceutical composition for preventing and treating constipation and affected biorhythm of defecation contains an active substance out of medicinal plant and a pharmaceutically acceptable filling agent, moreover, this preparation is designed as suppositories and contains either dry aqueous or aqueous-alcoholic extract of horse chestnut seeds of Aesculus species and suppository hydrophobic foundation at certain content of ingredients. Dry aqueous or aqueous-alcoholic extract contains 1-50% active substance as escin. As foundation it could contain either cacao oil or vitepsol. The method for preventing and treating constipations and affected biorhythm of defecation deals with introducing the suggested pharmaceutical composition into patient's anus 5-15 min before planned act of defecation. Application of "Rectum-activ" preparation provides positive result at treating functional psychogenic constipation: in 5-15 min after introducing a suppository into anus pronounced urgency for defecation. In case of course therapy for 4 wk one should observe restoration of natural urgency for intestinal evacuation. Moreover, purgative preparation causes no unfavorable pain feelings.

EFFECT: higher efficiency.

10 cl, 6 ex

FIELD: pharmaceutical industry.

SUBSTANCE: rectal- and vaginal-administration suppositories contain 1,3-diethylbenzimidazolium triiodide as active principal, polyvinylpyrrolidone as solubilizer and stabilizer, and lipophilic base with specified proportions of components.

EFFECT: extended therapeutical activity and reduced occurrence of side effects.

4 cl, 2 ex

FIELD: medicine, gynecology, pharmacology, pharmaceutical industry.

SUBSTANCE: invention proposes a preparation that comprises bacterial mass of live microorganisms as an active component, protecting medium and fat base. The preparation comprises lactobacilli as bacterial mass and one or some eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci taken in the amount per a single dose. Also, the preparation comprises additionally an acceptable sorbent and a biologically active supplement. Also, invention relates to a method for preparing this preparation that involves preparing firstly lactobacilli bacterial mass and one or some genus of eubiotic microorganisms taken among the following group: bifidobacteria, streptococci and lactococci. Then the prepared bacterial mass of microorganisms is immobilized on sorbent used in medicine in its ratio to bacterial mass of microorganisms = (9-1):(1-9) followed by addition of the protecting medium and biologically active supplement to formed mass in the necessary amount. Also, invention describes a method for prophylaxis and treatment of bacterial vaginitis that involves intravaginal administration of the preparation described above in the amount 1-3 doses, 1-3 times per 24 h. The treatment course is prescribed individually. Invention provides expanding assortment of agents used for treatment of bacterial vaginitis. Invention can be used in obstetric-gynecological practice.

EFFECT: improved method for vaginitis treatment, valuable medicinal properties of preparation.

13 cl, 4 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: means has dibunol, 15% oil extraction of propolis, gelatin, glycerol and treated water taken in known component proportion.

EFFECT: enhanced effectiveness of treatment; prolonged regenerating and antibacterial action.

2 cl

FIELD: medicine and immunology, in particular treatment and prevention immunodeficiency conditions and diseases associated with bacterial or viral aggression.

SUBSTANCE: claimed method includes administration to a patient immunoglobulin drug (e.g., pharmaceutical composition containing 6-12 % of specific heterologous secreted immunoglobulin A, isolated from milk or foremilk of immunized ungulates). Administration is performed parenterally wherein single dose is at least 10 IU/kg of patient weight for treatment or at least 5 IU/kg for prophylaxis; or perorally in dose of 0.2-0.5 g and/or topically one-two times per day for 1-5 days. Method of present invention makes it possible to decrease dose of administrating immunoglobulin due to prolonged retention of its high titers in body fluids.

EFFECT: enlarged range of application and assortment of immunoglobulin drugs.

4 cl, 5 ex

FIELD: medicine, proctology, pharmaceutics.

SUBSTANCE: the present innovation deals with obtaining medicinal forms as suppositories applied for treating proctological diseases. Medicinal preparation as suppositories containing active substance, anesthetic, purified water and foundation could additionally contain antiseptic and local irritating substance, as an active substance - glucocorticoid at the following ratio of components, weight%: glucocorticoid 0.0277-0.0368, anesthetic 1.8-2.2, antiseptic 2.8-3.52, local irritating substance 0.288-0.352, purified water 1.8-2.2, foundation - the rest. As glucocorticoid that inhibits the release of inflammation mediators and causes pronounced antiphlogistic and antiallergic action one should apply, for example, hydrocortisone or synaflane. As anesthetic one should apply, for example, anesthesin, lidocaine or trimecaine. As antiseptic being of astringent, drying off and analgesic actions one should apply, for example, dermatol or xeroform. As local irritating substance being of reflector, venotonic, analgesic and antiphlogistic and, also, antimicrobial actions one should apply, for example, racemic menthol or essential oils.

EFFECT: higher therapeutic efficiency.

5 cl, 3 ex, 4 tbl

FIELD: pharmaceutical industry.

SUBSTANCE: new urogenital drug contains 50-250 g antibacterially efficient antibiotic erythromycin, 50-250 g antifungally efficient antibiotic nistatin, antiprotozoal preparation metronidazole, and 1.5-3.5 g (to complete weight of suppository) A type solid fat as filler. Drug can be used to treat mixed urogenital infections.

EFFECT: reduced treatment time, lowered recurrence of diseases, lack of adverse effects, and lowered cost.

FIELD: medicine, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to the development of new homeopathic suppository that can be used for treatment of prostatitis, hemorrhoid, uterus cervix erosion, endometritis. Invention proposes two variants. By the first variant agent represents suppository comprising the following components, g: propolis, 0.1; sea-buckthorn, 0.2; chestnut homeopathic essences, 0.1; Ginkgo biloba homeopathic essences, 0.1; aloe homeopathic essences, 0.1; milfoil, 0.1; wax, 0.1 and a base. The second variant represents suppository comprising the following components, g: sea-buckthorn, 0.2; propolis, 0.1; rue homeopathic essences, 0.05; Hypericum (Saint-John's-wort), 0.05; Symphytum (comfrey), 0.05; Tambukan curative muddy extract, 0.2; lanolin, 0.15; wax, 0.1, and a base. Proposed suppository elicits an anti-inflammatory regenerating effect and without toxic effect.

EFFECT: valuable medicinal properties of suppository.

15 cl, 4 ex

FIELD: medicine, gynecology, contraceptives, pharmaceutical chemistry.

SUBSTANCE: invention proposes vaginal suppository comprising benzalconium chloride, benzoic acid, purified water and the preparation vitespol taken in the definite content of components. Invention provides the reliable inhibition of fungal microflora being especially against fungus Candida albicans and the absence of irritation and symptoms in vagina drying. Invention can be used as an individual agent for prophylaxis of undesirable pregnancy.

EFFECT: valuable properties of suppository.

5 tbl

FIELD: veterinary pharmacology, veterinary science.

SUBSTANCE: the suggested method deals with mixing formalin with components followed by heating with subsequent cooling at the following ratio of components including: 0.8%-formalin 5 ml, analgin 1 g, Veratrum tincture 1.0 ml, glycerol 5 ml, citric acid 0.2 g, gelatin 3 g.

EFFECT: enhanced curative result, more convenient medicinal form.

1 ex, 2 tbl

Up!