Film products with controlled degradation properties

FIELD: chemistry.

SUBSTANCE: invention relates to film compositions, which contain in a single layer: a) at least one water-insoluble polymer; b) at least one debonder from the group, which consists of water-insoluble particles, plastisizer and mixtures thereof; c) optionally, at least one local or system agent, where the film aqueous degradation is possible.

EFFECT: film with barrier characteristics and controlled degradation properties.

14 cl, 7 ex

 

The scope to which the invention relates

This application is a partial continuation of application for U.S. patent No. 10/792362, filed March 3, 2004, which is hereby incorporated in its entirety by reference, as if it were fully set forth herein.

This invention generally relates to films having barrier properties, and adjustable decay properties and, more specifically, to the films with adjustable decay in the water.

The level of technology

Known for a variety of products for local use, including strips, tapes, plasters, etc. These products are particularly applicable where the recommended protective film means or preferably the holding of a drug or medication.

Film protective equipment is especially desirable in situations where there are wounds or surface holes that need to be protected. Alternative mechanical retention of a drug or drug is particularly desirable where the drug or the drug can be easily removed by the rinsing or wiping the area of application (e.g., transdermal application).

More recently, products like strips or films again became popular in the field of care for the oral cavity. Of particular interest was paid to the areas on which belevalia teeth and oral percutaneous administration of drugs and medications.

Although disclosed a variety of products such as strips or films, there is still a need for improved film or plecoptera compositions that are easier to use and reduce the inconvenience or discomfort, typically associated with the attachment of such foreign objects to sensitive parts of the body.

One drawback observed in the above-mentioned products, films or strips, refers to the need, ultimately, to clean off or any other way to remove and get rid of the product film or strips after the introduction of local or systemic asset.

Addressing this shortcoming, the authors of the present invention have found that a film of the composition containing the selected water-insoluble polymers and baking powder selected from the group consisting of a plasticizer, water-insoluble particles or mixtures thereof, allow to obtain a film composition with good protective properties, as well as improved properties of decay.

Accordingly, one aspect of the present invention is to provide improved film products which possess protective properties that film prevents penetration of foreign substances, chemicals, or assets from one side of the film to another.

Another aspect of the present invention enables the fast is to provide film products with adjustable (or long type, or extended) properties of disintegration or dissolution in aqueous media.

One other aspect of the present invention is to provide film products for local or systemic delivery of the assets.

And another aspect of the present invention is to provide film products for local or systemic delivery of assets, where the film dissolves in the water environment within 60 minutes, not necessarily within 45 minutes, not necessarily within 30 minutes or optional within 15 minutes.

The invention

The present invention relates to film compositions containing at least one water-insoluble polymer, baking powder selected from the group consisting of a plasticizer, water-insoluble particles or mixtures thereof, and optionally at least one local or systemic asset, where the film is able to disintegrate in an aqueous environment is partially, substantially or completely. Film composition of the present invention can be used in the form of a single film or in combination with one or more additional film layers, forming two - or multi-layer film product.

In one embodiment, the film according to the present image is meniu may be in the form of a single-layer film, containing adhesive composition, where the adhesive composition contains a sticky substance, and local or systemic asset. Then the film is placed on the teeth, mucous membrane, or other damaged area of the skin or mouth, and allow it to disintegrate over time in the presence of liquids in the oral cavity or other aquatic environments.

In another embodiment, the film according to the present invention forms the first layer, or the substrate two-layer film, where the second layer is a film of water soluble polymer, such as described in U.S. patent No. 6596298 issued by Leung and others, and 6419903 issued by Xu and others, both of which are incorporated herein in their entirety by reference. Then a two-layer film is put on the teeth, mucous membrane, or other damaged area of the skin or mouth and allow it to disintegrate over time in the presence of liquids in the oral cavity or other aquatic environments.

Similarly the film of the present invention can be embedded in the multilayer film and use, as described above, in order to achieve the advantages of the present invention.

Also disclosed are methods of applying the above film compositions.

Detailed description of the present invention

Film composition of the present invention may contain, consist of, or essentially consist of significant the elements and limitations of the invention, described in this document, as well as any additional or optional ingredients, components, or limitations described in this document.

Unless otherwise stated, all percentages, parts and ratios are based on the total weight of the wet film composition of the present invention. If not indicated otherwise, all such masses, because they belong to listed ingredients are based on the level of the asset and, therefore, do not include carriers or by-products that may be included in commercially available materials.

The term "safe and effective amount"as used herein means an amount of compound or composition, such as local or systemic asset, sufficient to significantly stimulate a positive effect, such as whitening, anti-microbial and/or analgesic effect, independently including the effects disclosed herein, but low enough to avoid serious side effects, i.e. to ensure a reasonable ratio of benefit and risk within the sound judgment of a specialist.

The term "adhesive"as used herein means any material or composition that can stick to the local area of application or use, and includes, but is not limited to adhesives,sticky to slimy, a pressure-sensitive adhesive (sticks during the application of pressure), capable of wetting the adhesive (stick in the presence of water) and adhesives adhesive or sticky type (stick in direct contact with the surface).

The term "foreign substances"as used herein means dirt, infectious microorganisms, etc.

Film composition of the present invention is not necessarily transparent. The term "transparent"as defined herein, may mean from fully transparent to translucent, as seen with the naked eye.

Film composition of the present invention, including the required and optional components are described in detail next.

Water-insoluble polymer

Film composition of the present invention include water-insoluble polymers. Suitable water-insoluble polymers include, but are not limited to hydrogenated vegetable oils; natural resins, such as the extraction of rosin and gum rosin; vegetable proteins such as protein maize, pea protein or soy protein; hydrogenated castor oil; polyvinyl chloride; shellac; polyurethane; cellulose derivatives such as cellulose or ethylcellulose; waxes; resins, such as prodave what's under the trademark Eudragit RS, or mixtures thereof.

Hydrogenated vegetable oil suitable for use here include, but are not limited to hydrogenated forms safflower oil, castor oil, coconut oil, cottonseed oil, canola oil, oil Menhaden, stone fruits, palm oil, palm oil, peanut oil, rapeseed oil, linseed oil, rice oil, pine oil, sesame oil, sunflower oil, hydrogenated sunflower oil and mixtures thereof.

Examples of waxes suitable for use here include, but are not limited to paraffin, Carnauba wax, candelilla wax, cane wax, bees wax, wax complex atilovykh esters, montanum wax, gligovska, gidrirovanny castor oil, spermaceti wax, shellac wax, microcrystalline wax, petrolatum and mixtures thereof.

The Eudragit polymers are polymeric lacquer substances based on acrylate and methacrylate. The polymers sold under the trademark Eudragit RL and RS represent a resin containing copolymers of esters of acrylic and methacrylic acid with a low content of Quaternary ammonium groups, described in the brochure "Eudragit" Rohm Pharma GmbH (1982), which contains detailed physico-chemical information on these products. Ammonium groups are present as salts and m is avleat permeability of films of varnish. Eudragit RL and RS, respectively, highly permeable to water (RL) and poorly permeable to water (RS), regardless of pH. For more water-insoluble polymers are described in U.S. patent No. 6183777; 4721619; and 6251427, each of which is incorporated herein in its entirety by reference.

Can also be used mixtures of any of the above components.

In a specific embodiment, water-insoluble polymer may contain shellac, sold under the name Pharmaceutical Glaze that comes Mantrose Haeser Co., Attleboro, Massachusetts.

Water-insoluble polymer, which is included in the film composition of the present invention, is present in a concentration of from about 10% to about 80%, optionally from about 15% to about 40%, and optionally from about 20% to about 35% by weight of the wet film composition.

Baking powder

Plasticizers or plasticizing means

Film composition of the present invention also contain at least one powder selected from the group consisting of plasticizers or giving plasticity means of water-insoluble particles or mixtures thereof.

Examples of suitable plasticizers include, but are not limited alkylamino esters of citric acid, an ester of the mi glycerin, such as glycerylmonostearate and glycerylmonostearate, alkylamino esters of phthalic acid, alkylamino esters sabatinovka acid esters of sucrose, esters sorbitan, acetylated with monoglycerides, glycerine, glycols, esters of fatty acids, propylene glycol and polyethylene glycols 200-12000, and mixtures thereof. Specific plasticizers include, but are not limited to lauric acid, sucrose, sorbitol, triethylcitrate, acetylsalicylate, triacetine (glyceryltrinitrate), poloxamers, alkylarylsulfonate, diethylphthalate, tributyltin, dibutyl phthalate, dibutylsebacate, Polysorbate, polyethylene glycol series Carbwax® (Union Carbide Corporation), and mixtures thereof.

In certain embodiments of the implementation of the plasticizers may include mono - and diglycerides of edible fats or oils, supplied by Lonza Inc., Fair Lawn, NJ, or Eastman Triacetin (food grade)supplied by Eastman Chemical Company, Kingsport, TN.

The plasticizer, which is included in the film composition of the present invention, is present in a concentration of from about 0.1% to about 10%, preferably from about 0.1% to about 5%, and most preferably from about 0.5% to about 1.5% by weight of the wet film composition.

Water-insoluble particles

Will loosen the l can also be a water-insoluble particle. As water-insoluble particles can be used various kinds of organic powders and inorganic powders.

Inorganic powders that are applicable here include, but are not limited to microparticles or granules of alumina, talc, magnesium stearate, titanium dioxide, barium titanate, magnesium titanate, calcium titanate, strontium titanate, zinc oxide, quartz sand, clay, mica, layered feldspar, diatomaceous earth, various inorganic oxide pigments, chromium oxide, cerium oxide, red iron oxide pigment, sesquioxides antimony, magnesium oxide, zirconium oxide, barium sulfate, barium carbonate, calcium carbonate, silicon dioxide (colloidal or white soot), a silicon carbide, a nitride silicon, boron carbide, tungsten carbide, titanium carbide, carbon black and mixtures thereof.

Organic powders that apply here include powders of cross linked and not cross linked polymers, organic pigments, means controlling the charge, and waxes, for example. Powders of cross linked and not cross linked polymers include, but are not limited to powders, resins, styrene type, acrylic type, methacrylic type, polyethylene type, polypropylene type, silicone type, polyester type, polyurethane type, gender of the amide type, epoxy type, butyral resin type, resin type, terpene type, phenol type, melamine type and wanamingo type, for example. It is also possible to use mixtures of any of the above-mentioned organic or inorganic powders. Additional particles that are applicable in the present invention, can be found in U.S. patent No. 6475500; 5611885; and 4847199, each of which is incorporated herein in its entirety by reference.

Water-insoluble particles of the present invention typically have a particle size less than 10 microns, optionally from about 0.01 micron to about 5 microns, optionally from about 0.1 micron to about 1 micron, and optionally from about 0.1 to about 0.5 micron.

In certain embodiments of the implementation of the insoluble particles may include Cabosil M-5 (untreated pyrogenic silicon dioxide), supplied by Cabot, Tuscola, Illinois.

Water-insoluble particle, which is included in the film composition of the present invention, is present in a concentration of from about 0.1% to about 20%, optionally from about 0.5% to about 15%, and optionally from about 1% to about 10% by weight of the wet film composition.

If the film of the present invention forms the first layer, or the substrate of the multilayer film or two-layer film, the thickness of this first layer or the substrate may not necessarily be from about 1 micron to about 20 microns, optionally from about 3 microns to about 15 microns, optionally from about 5 microns to about 12 microns. The thickness of any additional layers may be equal to the range of thicknesses of the first layer or substrate, or range from approximately 30 microns to approximately 150 microns, optionally from about 45 microns to about 130 microns, optionally from about 70 microns to about 120 microns.

Optional ingredients

In the film of the present invention can also include a variety of local and system assets. The term "local and systemic assets", which is used in this document includes curative, preventive and cosmetic active substances or their compositions. Examples of conditions that can be directed to these substances include, but are not limited to one or more of the appearance and structural changes to teeth bleaching, bleaching of stains, removal of stains, removal of plaque, remove Tartar, preventing the formation of cavities and their treatment, inflamed and/or bleeding gums, wounds, mucous membrane lesions, ulcers, aphthous ulcers, g is Risa, abscesses of the teeth, pain in the teeth or gums, tooth sensitivity (e.g. temperature change) and eliminating unpleasant odor caused by the above conditions and other reasons, such as the proliferation of microbes. In addition, the films of the present invention is suitable for treatment and/or prevention of wounds, lesions, ulcers, herpes and the like on the lips and the skin in General.

Appropriate local assets for use in the oral cavity and around it include any substance that is generally considered safe for use in the oral cavity and which provides the transition to the complete health of your mouth. The level of local assets to care for the oral cavity according to the present invention may generally be from about 0.01% to about 40%, or optionally from about 0.1% to 20% by weight of the wet film.

Local assets to care for the oral cavity according to the present invention may include many assets previously disclosed in the art. The following is a list containing all the assets to care for the oral cavity, which can be used according to the present invention.

Essential oils can be included in the film or are associated with the films of the present invention. Essential oils, suitable for use here is described in detail in U.S. patent No. 6596298 Leung and others, is anee incorporated fully by reference.

In the film of the present invention can be included assets, whitening teeth. Assets that are suitable for whitening, selected from the group consisting of oxalate, peroxide, chlorite metals, perforated, percarbonates, peroxyketal and mixtures thereof. Suitable peroxide compounds include hydrogen peroxide, calcium peroxide, sodium peroxide, carbamide peroxide, urea peroxide, percarbonate sodium and mixtures thereof. Optional peroxide is hydrogen peroxide. Suitable metal chlorites include chlorite calcium, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Additional bleaching assets may be hypochlorite and chlorine dioxide. The preferred chlorite is sodium chlorite. The effectiveness of bleaching assets optional can be enhanced by catalyst, for example, two-component system of the peroxide catalyst. Suitable catalysts bleaching products or catalytic tools can be found in U.S. patent No. 6440396, issued to Gerald McLaughlin, which is incorporated herein in its entirety by reference.

Film composition of the present invention, part of which included peroxide assets may optionally contain stabilizers, peroxide assets. The peroxide stabilizers assets suitable for use is isawanya here include, but are not limited to glycols, such as PEG 40, PEG 600; salts of zinc, such as zinc citrate; polyalkylene block copolymers (e.g., Pluronics); aminocarbonyl acids or their salts; dyes, such as blue No. 1 or green No. 3; phosphate, such as phosphoric acid, sodium phosphate, or acidic sodium pyrophosphate; tin salts such as tin chloride; stannate sodium; citric acid; etidronate acid; Carbonari or carboxypolymethylene, such as the Carbopol series®; butilirovannyh hydroxytoluene (BHT), ethylenediaminetetraacetic acid (EDTA) and mixtures thereof.

Tools to combat Tartar applicable here include phosphates. The phosphates include pyrophosphates, polyphosphates, polyphosphonates and mixtures thereof. Pyrophosphates are one of the most well-known for use in products for oral care mouth. Pyrophosphate ions coming to the teeth, hatshepsuts from pyrophosphate salts. Pyrophosphate salt, applicable in the present compositions include pyrophosphates with two cations, alkali metal pyrophosphates with four cations of alkali metals and their salts. Preferred digidrirovannye dihidrogenofosfat disodium (Na2H2P2O7), the pyrophosphate tetranitride (Na4P2O7) and the pyrophosphate tetracene (K4P2Osub> 7). Phosphates to fight Tartar include pyrophosphates, potassium and sodium; sodium tripolyphosphate; diphosphonates, such as ethane-1-hydroxy-1,1-diphosphonate; 1-azacycloheptane-1,1-diphosphonate; and linear alkyldithiophosphate; linear carboxylic acid and sodium citrate and zinc.

Tools that can be used instead of or in combination with pyrophosphate salt include substances such as synthetic anionic polymers, including polyacrylates and copolymers of maleic anhydride or acid and a simple ester methylvinyl (e.g., Gantrez, which is described, for example, in U.S. patent No. 4627977 issued Gaffar and others, which is incorporated herein in its entirety by reference), as well as, for example, polyaminopropyl acid (AMPS), the trihydrate of zinc citrate, polyphosphates (e.g., tripolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP, AMP), polypeptides (such as poliasparaginovaya and polyglutamine acid) and mixtures thereof.

As anticariogenic funds in film composition included one of the more sources of fluoride ions. Fluoride ions include many compositions for oral care mouth for this purpose and they can also be included in the invention in the same way. Detailed examples of such sources of fluoride ions can be found in U.S. patent No. 6121315 issued by Nair and others, which included what this document in its entirety by reference.

Here are also applicable means of reducing tooth sensitivity. Means of reducing tooth sensitivity, which can be used in the present invention include potassium nitrate, citric acid, salts of citric acid, strontium chloride and the like, as well as other lower sensitivity means known in the art. The quantity of reducing the sensitivity of the tools included in the composition for tooth whitening according to the present invention, may vary in accordance with the concentration of potassium nitrate, the desired strength and the anticipated time of treatment. Accordingly, other means of reducing the sensitivity, if it is included at all, will preferably be included in an amount of from about 0.1% to about 10% by weight of the dental desensitizing composition, more preferably from about 1 to about 7% by weight of the wet film composition.

In the film compositions of the present invention may also be present antimicrobial agent in the form of oral means or local skin and/or system assets. Such means may include, but are not limited to, 5-chloro-2-(2,4-dichlorophenoxy) - phenol, commonly known as triclosan, chlorhexidine, alexidine, hexetidine, chelerythrine, benzalkonium chloride, salicylamide, domiphen bromide is, cetylpyridinium chloride (CPC), tetradecylbenzene chloride (TPC); N-tetradecyl-4-ethylpyridine chloride (TDEPC); octenidine; delmopinol, ottapidaram and other derivatives piperidine; preparations of Niacin; zinc/tin ion means; antibiotics such as Augmentin, amoxicillin, tetracycline, doxycycline, minocycline, and metronidazole; and analogs, derivatives and salts of the above antimicrobial agents, and mixtures thereof.

In the film compositions of the present invention can also be anti-inflammatory agent in the form of oral means or local skin and/or system assets. Such means may include, but are not limited to, non-steroidal anti-inflammatory drugs, or NSAIDs, such as propionic acid derivatives; derivatives of acetic acid; derivatives of Funambol acid; derivatives of biphenylcarbonic acid; and execumama. All data NSAIDs fully described in U.S. patent No. 4985459 issued Sunshine and other January 15, 1991, which is incorporated herein in its entirety by reference. Examples of applicable NSAIDs include acetylsalicylic acid, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, Ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiapride the OIC acid, fluprofen, bulokovu acid and mixtures thereof. Also applicable steroid anti-inflammatory agents such as hydrocortisone and the like, and inhibitors of COX-2, such as meloxicam, celecoxib, rofecoxib, valdecoxib, etoricoxib or mixtures thereof. Can be used mixtures of any of the above anti-inflammatory drugs.

You can also include the anaesthetic. Examples of suitable anaesthetics include, but are not limited to, benzocaine, biloxicasino, mefenamico, bupivacaine, butacaine, dibucaine hydrochloride, dyclonine, lidocaine, mepivacaine, procaine, PROPANEDIOL, proparacaine, propagana, propiomazine, propofol, propoxycaine hydrochloride, pseudococaine, tetracaine hydrochloride and mixtures thereof.

You can also use assets, operating in the upper respiratory tract. Examples of such assets are sympathomimetic funds, administered systemically or topically for decongestant use, and include propylhexedrine, phenylephrine, phenylpropanolamine, pseudoephedrine, nafazolina hydrochloride, Oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, Xylometazoline hydrochloride and itineration hydrochloride; antihistamines are chlorpheniramine, brompheniramine, clemastine, ketotifen, astad is h, loratadine, terfenadine, cetirizine, astemizole, tsivilis, levocabastine, diphenhydramine, clemastine, atomotive, acrivastine, azelastine, Bastin, mequitazine, mizolastine, levocetirizine, mometasone furoate, carebastine, ramatroban, desloratadin, doberstyn, selenotypus, alystin, efletirizine, tritoqualine, erastamisel, Thoresen, epinastine, acrivastine and mixtures thereof; antitussives such as dextromethorphan, benzonatate and guaifenesin, and mixtures thereof. Other applicable assets, operating in the upper respiratory tract can be found in U.S. patent No. 4619934, incorporated herein in its entirety by reference.

You can also include gastrointestinal assets. Examples of suitable gastrointestinal assets include anticholinergics, including atropine, clydine villamin; antacids, including aluminum hydroxide, basic bismuth salt such as bismuth subsalicylate, ranitidine bismuth citrate, bismuth subcitrate, bismuth subnitrate, aluminium salts or bismuth polyzwitterionic saccharides, such as aluminum sucrose octasulphate or bismuth sucrose octasulphate, simethicone, calcium carbonate and magaldrate (other examples of antacids can be found in 21CFR 331.11, which is incorporated herein by reference); antagonists of H (2)receptors, including cimetidine, famotidine, nizatidine, and R is nitidine; laxatives, including Bisacodyl, picosulfate and casandra (other examples laxatives can be found in the Federal Registry, Vol.50, No. 10, Jan. 15, 1985, pp.2152-58, which is incorporated herein by reference); gastroprotective, including sukralfat and wet gel sukralfat; gastrokinetic and prokinetic, including cisapride, metoclopramide and Azipod; proton pump inhibitors, including omeprazole, lanzoprazol, and Antidiarrhoeal tools, including Diphenoxylate and loperamide; means with bacteriostatic or bactericidal effect on ulcerogenic the bacterium Heliobacter pylori, such as amoxicillin, metronidazole, erythromycin, or nitrofurantoin, and other means for treatment of H. pylori disclosed in U.S. patent No. 5256684, which is included in this document in all entirety by reference; polyanionic substances suitable for the treatment of ulcers and other gastrointestinal disorders, including amylopectin, carragenan, sulfated dextrin, Inositol of hexaphosphate or other similar substances and their mixtures.

Nutrients can improve the condition of the oral cavity and can include a substance or composition for caring for the oral cavity according to the present invention. Examples of nutrients include minerals, vitamins, oral nutritional supplements, intestinal food additives and mixtures thereof.

In film composition on n the present invention can also include means, facilitating Smoking cessation such as nicotine.

In of a substance or composition for caring for the oral cavity according to the present invention can also include a separate enzyme or a combination of several compatible enzymes.

Enzymes are the biological catalysts of chemical reactions in living devices. Enzymes are combined with the substrates on which they act, forming an intermediate complex enzyme-substrate. This complex is then transformed into the reaction product and the released enzyme, which continues its specific enzymatic function.

Enzymes provide several advantages when used for cleaning the mouth. Proteases break down proteins of saliva absorbed on the surface of the teeth and form plaque; the first layer of the resulting plaques. Protease along with lipases destroy bacteria by degradation of proteins and lipids that form the structural component of bacterial cell walls and membranes. Dextranase breaks down organic skeletal structure produced by the bacteria that forms the matrix for adhesion of bacteria. Protease and amylase not only prevent the formation of plaques, but also prevent the development of stone, destroying the carbohydrate-protein complex, which binds calcium, preventing mineralization. F is renty, applicable for the present invention include any commercially available protease, glucanohydrolase, endoglycosidase, amylase, Athanasy, lipase and mucinase or compatible mixtures thereof. Preferred protease, dextranase, endoglycosidase and atanazy preferred papain, endoglucanase, lysozyme, or a mixture of dextranase and atanazy.

Other materials that can be used in conjunction with the present invention include well-known products for the mouth and pharynx. These products include, but are not limited to anti-fungal, antibiotic and analgesic agents. Antioxidants generally recognized as applicable in the compositions, such as compositions of the present invention. Antioxidants that may be included in the composition or substance to care for the oral cavity according to the present invention, include, but are not limited to vitamin E, ascorbic acid, uric acid, carotenoids, vitamin a, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoedema acids and mixtures thereof.

In a composition for caring for the oral cavity according to the present invention can be used connection - antagonists histamine H-2 receptor (H-2 antagonists). As used herein, selective H-2 antagonists represent a link is, which block H-2 receptors, but lack significant activity by blocking histamine H-1 receptors.

Additional applicable assets can be found in U.S. patent No. 6638528, incorporated herein fully by reference.

To the film composition of the present invention can also add additional media. These substances can be added as additional components to properties differing from those previously mentioned, and may include humidifiers and include glycerin, sorbitol, polyethylene glycol, etc. Film composition may contain the substance itself, together with one or more substances-amplifiers, such as catalysts and/or potentiating means changing the release and/or activity of a substance.

Film composition according to the invention can optionally contain additional substances such as flavorings, dyes, etc. which, for example, can be precipitated on the surface of the film or to impregnate them the main part of the film. Local or systemic asset preferably is a substance, whitening teeth. Substances, whitening teeth, can take the form of a gel containing peroxide. Suitable gels can be based on glycerol, a peroxide such as hydrogen peroxide or organic peroxide. Appropriate elem is disclosed in US-A-3657413, for example that sold under the trademark PROXIGEL by the Block Drug Company (USA) (later acquired by GlaxoSmithKline plc). Other suitable gels containing peroxide, for example, disclosed in the above-quoted references on the technique. The film may be local or systemic asset deposited on its surface.

To optimize the stability of the gel during storage and to make the substance is safe for tissues of the mouth, you can add a means of regulating pH. These funds, regulating pH, or buffers can be any substance which is suitable for adjusting the pH of a substance to care for the oral cavity. Suitable substances include sodium bicarbonate, sodium phosphate, sodium hydroxide, ammonium hydroxide, stannate sodium, triethanolamine, citric acid, hydrochloric acid, sodium citrate and combinations thereof. Means regulating the pH, are added in sufficient quantity to bring the pH of a substance or composition to a suitable value, for example from about 4.5 to about 11, preferably from about 5.5 to about 8.5, and more preferably from about 6 to about 7. Means regulating the pH, usually present in amounts of from about 0.01% to about 15% and preferably from about 0.05% to about 5% by weight of substances which tion to care for the oral cavity.

For example, the gel can be directly applied as a layer on the surface of the film layer, which is described above. Alternative gel can adsorb the above-described layer of the film or to impregnate them the main part of the film material, or precipitate between the layers of the multilayer film.

The ways of applying substances on the surface of the film material described above is known, for example, screen printing, run between the impregnated rollers, dosing pump with nozzle, spraying, immersion, etc. Methods of impregnation substances the main part of the film materials are also known, for example, mixing of the substance with the material strip and then forming strips or the exposure of the strips to the effects of a substance under conditions which cause the impregnation of the strip material. Alternative one copy of the film material may be a foamed material, particularly foamed material with open cells, and the material strips can be impregnated with a substance through the introduction of substances into the cells of the foam.

In another embodiment, the film of the present invention is formed from a first layer, or the substrate of the double layer, where the second layer is a layer film of a water-soluble polymer, such as described in U.S. patent No. 6596298 issued by Leung and others, and 6419903 issued by Xu and others, both of which are included is this document in its entirety by reference. Then a two-layer film is put on the teeth, mucosa of the oral cavity or other affected area of the skin or mouth, and allow it to disintegrate over time in the presence of saliva or other aqueous media.

In addition, the layers of the film according to the present invention can be manufactured using the methods of extrusion of the hot melt, such as described in U.S. patent No. 6375963 B1, issued Repka and others, which is incorporated herein in its entirety by reference.

The device according to the invention may be labeled with one or more visible symbol, such as textual material, brand name, company logo, color area or a sign of alignment, such as a visible line or the notch, etc. to help the user to correctly align the device when applying it to the teeth. Such sign alignment may, for example, include a symbol, which indicates to the user how the device should be on top when applying the device to the teeth, or what of the pair of devices is intended for upper teeth and a lower teeth. Thus the device can be made more attractive and/or easier to use. This character (s) can be applied by conventional methods of printing or embossing, for example, screen printing, inkjet printing, etc. on the surface material, capable of plastic deformation on the surface opposite to that to which is attached a layer of absorbent material.

If such a visible symbol superimposed on this surface, on top of the symbol is not necessary to impose the covering layer, for example, in order to protect him. This coating layer may be transparent or translucent to make the characters visible through the layer. Such a coating layer can optionally be applied to the film by extrusion, for example by rolling the material of a coating layer in contact with the film.

Methods of local administration and system assets

The present invention can be used where local activity or an adequate system of suction required to hold local or systemic asset. Film composition of the present invention is particularly applicable to the whitening of the tooth surfaces. As a rule, the introduction of assets, whitening teeth, including local overlay film according to the invention contain a safe and effective amount of these assets, on the tooth or teeth and gums in the manner described in U.S. patent No. 5894017; 5891453; 6045811; and 6419906, each of which is incorporated herein in its entirety by reference. The frequency of application and the period of use will vary widely depending on the desired or telemag the level of treatment, for example, the degree of whitening of the teeth and/or the desired degree of healing/local disinfection of the wound.

The film of the present invention, which are imposed in the form of a patch on the skin or mucous membrane, may be applicable in the areas of skin problems that require more intensive treatment, or percutaneous injection. The patch can be occlusive, polioksidony or pollutionin. Local or systemic assets according to the present invention can be inside a film, or cover its surface, or applied to the skin before applying the film. In addition, the film can be applied wet to form a film, which dries out in place of the overlay. The film may also contain assets such as chemical initiators exothermic reactions as those described in PCT application WO 9701313 filed Burkett and other Optional film can be used at night as a form of night therapy. Examples of applicable percutaneous systems described in U.S. patent№ 3598122; 3598123; 3731683; 3797494; 4286592; 4314557; 4379454; 4435180; 4559222; 4568343; 4573999; 4588580; 4645502; 4704282; 4816258; 4849226; 4908027; 4943435 and 5004610 all of which are incorporated herein in its entirety by reference. Assets normally associated with percutaneous introduction, are disclosed in U.S. patent No. 5843468 and 5853751, both of which are incorporated herein in its entirety by the SS the CTL.

EXAMPLES

Film compositions illustrated in the following examples illustrate certain embodiments of the film compositions of the present invention, but not intended to be limiting thereof. A qualified technician can perform other modifications, without departing from the essence and scope of this invention.

All cited as an example of film composition can be prepared by conventional methods of preparing dosage forms and mixing. The number of the components are listed as weight percent and exclude minor materials such as diluents, fillers, etc. Therefore, these preparations contain the components listed above and any secondary materials associated with such components.

Example I

The following is an example of a single film of the present invention

IngredientNumber (percentage by weight)
Distilled water10,00
Isopropyl alcohol79,00
Silicon dioxide (fumed, raw)14,00
Glycerin USP, special2,00
Zein25,00
1Supplied under the trade name Cabosil® Cabot, Tuscola, Illinois.

2Protein from corn grain (supplied Freeman Industries, Tuckahoe, new York).

In a suitable beaker was mixed Zein, silicon dioxide, alcohol, glycerin and water until smooth and homogenous.

Then the contents of chemical glass poured to a desired thickness on a non-stick surface or the sheet at room temperature to form a film according to the invention.

Example II

The following is an example of a single film of the present invention

IngredientNumber (percentage by weight)
Alcohol USP/EP38,00
Silicon dioxide (fumed, raw)12,00
CAPOL 150260,00
1Supplied under the trade name Cabosil® Cabot, Tuscola, Illinois.

2Contains ethanol, shellac, hydrogenated vegetable oil (coconut origin) (comes Centerchem, Inc., Norwalk, CT).

In a suitable beaker was mixed Capol 150, silicon dioxide and alcohol to uniformity and homogeneity.

Then the contents of chemical glass poured to telemetering on a non-stick surface or the sheet at room temperature, to form a film according to the invention.

Example III

The following is an example of a colored film forming composition according to the present invention

IngredientNumber (percentage by weight)
Pharmaceutical glaze156,00
Magnesium stearate23,00
Triacetin31,00
Alcohol USP/EP40,00
1Shellac supplied Mantrose Haeser Co., Attleboro, Massachusetts.

2Magnesium stearate, Hyqual, derived from plants, comes Mallinckrodt Chemicals, Phillipsburg, new York.

3Eastman triacetin (food grade) supplied Eastman Chemical Company, Kingsport, Tennessee.

In a suitable beaker was mixed pharmaceutical glaze, magnesium stearate, triacetin and alcohol to uniformity and homogeneity.

Then the contents of chemical beaker was placed in a suitable airtight container for later application to the skin, teeth or oral mucosa by the consumer in the form of a colored film.

Example IV

The following is an example of a two-layer film for teeth whitening according to the present invention.

Sticky layer

ComponentNumber (percentage by weight)
Xanthan gum10,0174% wt./wt.
Carob bean gum, purified20,0348% wt./wt.
Carrageenan30,1740% wt./wt.
Pullulan44,1000% wt./wt.
Povidone, USP K-90512,4000% wt./wt.
Sucralose60,7000% wt./wt.
Potassium dihydroorotase NF0,0700% wt./wt.
Purified water, USP/EP72,4948% wt./wt.
Hydrogen peroxide 35%75,7100% wt./wt.
Flavor2,5890% wt./wt.
Polysorbate 80 NF/EP80,3550% wt./wt.
Emulsifier90,3550% wt./wt.
Glycerin USP special1,0000% wt./wt.

Layer pad

Pharmaceutical glaze, 4-LB CUT NF1055,0000% wt./wt.
Silicon dioxide11(pyrogenic, raw)4,0000% wt./wt.
Alcohol USP/EP40,0000% wt./wt.
Glits is restaurat SE 121,0000% wt./wt.
1Comes CP Kelco, Chicago, Illinois under the name Keltrol t

2Sold by Degussa Texturant Systems, Atlanta, GA called Viscogum BCR 20/80.

3Sold FMC Biopolymer, Philadelphia, Pennsylvania under the name of Viscarin SD339.

4Grade PI-20, supplied by Hayashibara.

5Polyvinylpyrrolidone, K USP-90, International Specialties Products (ISP), Wayne, new York.

6ALB CG 35% solution of hydrogen peroxide, Atofina, Philadelphia, Pennsylvania.

7Comes McNeil Pharmaceuticals, NewBrunswick, new York under the name Splenda®.

8Tween-80 comes Quest, Hoffinann Estates, Illinois.

9A mixture of mono - and dioleate supplied American Ingredients, Kansas City, Missouri under the name of Atmos 300.

10Shellac supplied Mantrose Haeser Co., Attleboro, Massachusetts.

11Comes Cabot, Tuscola, Illinois under the name Cabosil®.

12Comes Lonza Inc., Fair Lawn, new York in the form of mono - and diglycerides of fats and oils (daily demand).

In suitable chemical glass (glass A) was added with stirring the water, Sucralose, dihydroorotase potassium until then, until the mixture became homogeneous.

In a separate beaker (beaker B) dry mixed xanthan resin, carob bean gum, carrageenan, pullulan and Plasdone K-90, until the mixture mills who was homogeneous. The contents of beaker B was added into a glass And with rapid stirring or agitation. The combined mixture was stirred until such time as the resin does not become hydrated. To the combined mixture slowly with stirring was added hydrogen peroxide.

In a separate beaker (glass C) flavor, Polysorbate 80, glycerin and Atmos 300 was stirred until dissolution and uniformity. Then the contents of the glass C was poured into the beaker and stirred until then, until the mixture became homogeneous and homogeneous. Then the pH was brought about to 5.5, using a 1.0 n sodium hydroxide.

In another separate beaker (beaker D) was stirred pharmaceutical glaze, Cabosil, alcohol and literallayout to uniformity and homogeneity.

Then the contents of the glass D poured to a desired thickness on a non-stick layer at room temperature to obtain a film according to the invention or the first layer of two-layer films for whitening teeth.

Then the contents of the glass And poured to a desired thickness on top of the above described first layer at room temperature to obtain a second layer of two-layer films for whitening teeth.

Example V

The following is an example of a two-layer film for teeth whitening according to the present invention.

Sticky layer

ComponentNumber (percentage by weight)
Xanthan gum10,02308% wt./wt.
Carob bean gum, purified20,04616% wt./wt.
Carrageenan30,2308% wt./wt.
Povidone, USP K-90416,426% wt./wt.
Sucralose50,7000% wt./wt.
Potassium dihydroorotase NF0,0700% wt./wt.
Purified water, USP/EP72,4948% wt./wt.
Hydrogen peroxide 35%65,7100% wt./wt.
Flavor2,5890% wt./wt.
Polysorbate 80 NF/EP70,3550% wt./wt.
Emulsifier80,3550% wt./wt.
Glycerin USP special1,0000% wt./wt.

Layer pad

Pharmaceutical glaze, 4-LB CUT NF955,0000% wt./wt.
Silicon dioxide10(pyrogenic, raw)4,0000% wt./wt.
Alcohol USP/EP40,0000% wt./wt.
Literallayout SE111,0000% wt./wt.
1Comes CP Kelco, Chicago, Illinois under the name Keltrol t

2Sold by Degussa Texturant Systems, Atlanta, GA called Viscogum BCR 20/80.

3Sold FMC Biopolymer, Philadelphia, Pennsylvania under the name of Viscarin SD339.

4Polyvinylpyrrolidone, K USP-90, International Specialties Products (ISP), Wayne, new York.

5ALB CG 35% solution of hydrogen peroxide, Atofina, Philadelphia, Pennsylvania.

6Comes McNeil Pharmaceuticals, Philadelphia, PA called spenda on®.

7Tween-80 comes Quest, Hoffinann Estates, Illinois.

8A mixture of mono - and dioleate supplied American Ingredients, Kansas City, Missouri under the name of Atmos 300.

9Shellac supplied Mantrose Haeser Co., Attleboro, Massachusetts.

10Comes Cabot, Tuscola, Illinois under the name Cabosil®.

11Comes Lonza Inc., Fair Lawn, new York in the form of mono - and diglycerides of fats and oils (daily demand).

In suitable chemical glass (glass A) was added with stirring the water, Sucralose, dihydroorotase potassium until then, until the mixture became homogeneous.

In a separate beaker (beaker B) dry mixed xanthan resin, carob bean gum, carrageenan and Plasdone K-90, until the mixture became homogeneous. The contents of beaker B was added into a glass And with rapid stirring or agitation. United CME is ü mixed before hydration of the resin. To the combined mixture slowly with stirring was added hydrogen peroxide.

In a separate beaker (glass C) flavor, Polysorbate 80, glycerin and Atmos 300 was stirred until dissolution and uniformity. Then the contents of the glass C was poured into the beaker and stirred until then, until the mixture became homogeneous and homogeneous. Then the pH was brought about to 5.5, using a 1.0 n sodium hydroxide.

In another separate beaker (beaker D) was stirred pharmaceutical glaze, Cabosil, alcohol and literallayout to uniformity and homogeneity.

Then the contents of the glass D poured to a desired thickness on a non-stick layer at room temperature to obtain a film according to the invention or the first layer of two-layer films for whitening teeth.

Then the contents of the glass And poured to a desired thickness on top of the above described first layer at room temperature to obtain a second layer of two-layer films for whitening teeth.

Example VI

The following is an example of a two-layer film of bleaching teeth according to the present invention.

Sticky layer

ComponentNumber (percentage by weight)
Xanthan gum10,0674% wt./wt.
Carob bean gum, purified20,0848% wt./wt.
Pullulan34,1740% wt./wt.
Povidone, USP K-90412,4000% wt./wt.
Sucralose50,7000% wt./wt.
Potassium dihydroorotase NF0,0700% wt./wt.
Purified water, USP/EP72,4948% wt./wt.
Hydrogen peroxide 35%65,7100% wt./wt.
Flavor2,5890% wt./wt.
Polysorbate 80 NF/EP70,3550% wt./wt.
Emulsifier80,3550% wt./wt.
Glycerin USP special1,0000% wt./wt.

Layer pad

Pharmaceutical glaze, 4-LB CUT NF1955,0000% wt./wt.
Silicon dioxide10(pyrogenic, raw)4,0000% wt./wt.
Alcohol USP/EP40,0000% wt./wt.
Literallayout SE111,0000% wt./wt.
1Comes CP Kelco, Chicago, Illinois under the name Keltrol t

2Sold by Degussa Texturant Systems, Atlanta, GA called Viscogum BCR 20/80.

3the ORT PI 20, supplied by Hayashibara.

4Polyvinylpyrrolidone, K USP-90, International Specialties Products (ISP), Wayne, new York.

5ALB CG 35% solution of hydrogen peroxide, Atofina, Philadelphia, Pennsylvania.

6Comes McNeil Pharmaceuticals, Philadelphia, PA, under the name of spenda on®.

7Tween-80 comes Quest, Hoffimann Estates, Illinois.

8A mixture of mono - and dioleate supplied American Ingredients, Kansas City, Missouri under the name of Atmos 300.

9Shellac supplied Mantrose Haeser Co., Attleboro, Massachusetts.

10Comes Cabot, Tuscola, Illinois under the name Cabosil®.

11Comes Lonza Inc., Fair Lawn, new York in the form of mono - and diglycerides of fats and oils (daily demand).

In suitable chemical glass (glass A) was added with stirring the water, Sucralose, dihydroorotase potassium until then, until the mixture became homogeneous.

In a separate beaker (beaker B) dry mixed xanthan resin, carob bean gum, pullulan and Plasdone K-90, until the mixture became homogeneous. The contents of beaker B was added into a glass And with rapid stirring or agitation. The combined mixture was stirred until hydration of the resin. To the combined mixture slowly with stirring was added hydrogen peroxide.

In a separate beaker (glass C) flavor, Polysorbate 80, glycerin and Atmo 300 was stirred until dissolution and uniformity. Then the contents of the glass C was poured into the beaker and stirred until then, until the mixture became homogeneous and homogeneous. Then the pH was brought about to 5.5, using a 1.0 n sodium hydroxide.

In another separate beaker (beaker D) was stirred pharmaceutical glaze, Cabosil, alcohol and literallayout to uniformity and homogeneity.

Then the contents of the glass D poured to a desired thickness on a non-stick layer at room temperature to obtain a film according to the invention or the first layer of two-layer films for whitening teeth.

Then the contents of the glass And poured to a desired thickness on top of the above described first layer at room temperature to obtain a second layer of two-layer films for whitening teeth.

Example VII

The following is an example of a two-layer film for teeth whitening according to the invention.

Sticky layer

ComponentNumber (percentage by weight)
Dextrin11,9674% wt./wt.
Gum Arabic20,1848% wt./wt.
Pullulan32,1740% wt./wt.
Povidone, USP K-90412,4000% wt./wt.

Sucralose50,7000% wt./wt.
Potassium dihydroorotase NF0,0700% wt./wt.
Purified water, USP/EP72,4948% wt./wt.
Hydrogen peroxide 35%65,7100% wt./wt.
Flavor2,5890% wt./wt.
Polysorbate 80 NF/EP70,3550% wt./wt.
Emulsifier80,3550% wt./wt.
Glycerin USP special1,0000% wt./wt.

Layer pad

Pharmaceutical glaze, 4-LB CUT NF1955,0000% wt./wt.
Silicon dioxide10(pyrogenic, raw)4,0000% wt./wt.
Alcohol USP/EP40,0000% wt./wt.
Literallayout SE111,0000% wt./wt.
1Comes to Grain processing Corporation, Muscarine, Iowa under the trade name Pure-Cote B760.

2Sold TIC Gums, Belcamp, MD under the name Bright Gum Arabic Spray Dry FCC/NF Powder.

3Grade PI-20, supplied by Hayashibara.

4Polyvinylpyrrolidone, K USP-90, International Specialties Products (ISP), Wayne, new York.

5ALB CG 35% solution of hydrogen peroxide, Atofina, Philadelphia, Pennsylvania.
6Comes McNeil Pharmaceuticals,

Philadelphia called spenda on®.

7Tween-80 comes Quest, Hoffinann Estates, Illinois.

8A mixture of mono - and dioleate supplied American Ingredients, Kansas City, Missouri under the name of Atmos 300.

9Shellac comes Mantrose Haeser Co., Attleboro, Massachusetts.

10Comes Cabot, Tuscola, Illinois under the name Cabosil®.

11Comes Lonza Inc., Fair Lawn, new York in the form of mono - and diglycerides of fats and oils (daily demand).

In suitable chemical glass (glass A) was added with stirring the water, Sucralose, dihydroorotase potassium until then, until the mixture became homogeneous.

In a separate beaker (beaker B) dry mixed dextrin, gum Arabic, pullulan and Plasdone K-90, until the mixture became homogeneous. The contents of beaker B was added into a glass And with rapid stirring or agitation. The combined mixture was stirred until such time as the resin does not become hydrated. To the combined mixture slowly with stirring was added hydrogen peroxide.

In a separate beaker (glass C) flavor, Polysorbate 80, glycerin and Atmos 300 was stirred until dissolution and uniformity. Then the contents of the glass C was poured into the beaker and stirred until then, until the mixture became homogeneous and g is magenau. Then the pH was brought about to 5.5, using a 1.0 n sodium hydroxide.

In another separate beaker (beaker D) was stirred pharmaceutical glaze, Cabosil, alcohol and literallayout to uniformity and homogeneity.

Then the contents of the glass D poured to a desired thickness on a non-stick layer at room temperature to obtain a film according to the invention or the first layer of two-layer films for whitening teeth.

Then the contents of the glass And poured to a desired thickness on top of the above described first layer at room temperature to obtain a second layer of two-layer films for whitening teeth.

1. Film composition containing in a single layer:

a) at least one water insoluble polymer;

b) at least one powder selected from the group consisting of water-insoluble particles, plasticizer and mixtures thereof,

c) optionally, at least one local or systemic asset, where the film is capable of disintegration in the aquatic environment.

2. Film composition according to claim 1 where the water-insoluble polymer selected from the group consisting of hydrogenated vegetable oils, hydrogenated castor oil, polyvinyl chloride, shellac, polyurethane, cellulose derivatives, gum rosins, extraction rosins, waxes, p. the materials acrylate and methacrylate, copolymers of esters of acrylic and methacrylic acid, and mixtures thereof.

3. Film composition according to claim 2 where the water-insoluble polymer is a shellac.

4. Film composition according to claim 1, where the plasticizer is selected from the group consisting of alilovic esters of citric acid, esters of glycerin, alilovic esters of phthalic acid, alilovic esters sabatinovka acid esters of sucrose, esters sorbitan, acetylated monoglycerides, glycerine, glycols, esters of fatty acids, propylene glycol, poloxamer, alkylaromatic and glycols 200-12000 and mixtures thereof.

5. Film composition according to claim 4, where the plasticizer is a glycerol monostearate.

6. Film composition according to claim 1 where the water-insoluble particles selected from the group consisting of aluminum oxide, talc, titanium dioxide, magnesium stearate, barium titanate, magnesium titanate, calcium titanate, strontium titanate, zinc oxide, quartz sand, clay, mica, layered calcite, diatomaceous earth, various inorganic oxide pigments, chromium oxide, cerium oxide, red iron oxide pigment, sesquioxide antimony, magnesium oxide, zirconium oxide, barium sulfate, barium carbonate, calcium carbonate, silicon dioxide, silicon carbide, silicon nitride, carb is Yes boron, tungsten carbide, titanium carbide, carbon black and mixtures thereof.

7. Film composition according to claim 1 where the water-insoluble polymer is a pyrogenic silicon dioxide.

8. Film composition according to claim 1, which further comprises at least one local or systemic asset.

9. Film composition according to claim 1, where one local or systemic asset selected from the group consisting of bleaching products, anti deposits of Tartar, sources of fluoride ions, antimicrobial agents, antiinflammatory agents, agents affecting the upper respiratory tract, gastro-intestinal agents, enzymes, antifungal agents, antibiotics, analgesic means, histamine antagonists and mixtures thereof.

10. Multilayer film composition comprising at least two film layers, where at least one layer contains (a) at least one water insoluble polymer; b) at least one powder selected from the group consisting of water-insoluble particles, plasticizers and mixtures thereof; c) optionally at least one local or systemic asset, where the film is capable of disintegration in the aquatic environment.

11. Film composition of claim 10, which further comprises at least one local or systemic asset.

12. Film composition according to claim 11, where the local or system is hydrated asset selected from the group consisting of bleaching products, anti deposits of Tartar, sources of fluoride ions, antimicrobial agents, antiinflammatory agents, agents affecting the upper respiratory tract, gastro-intestinal agents, enzymes, antifungal agents, antibiotics, analgesic means, histamine antagonists and mixtures thereof.

13. Film composition according to item 12, where the local system or asset is a bleaching agent.

14. Film composition according to item 13, where a bleaching agent selected from the group consisting of peroxides, metal chlorite, perforated, percarbonates, peroxyketal and mixtures thereof.

15. Film composition according to 14, where the bleaching agent is hydrogen peroxide.



 

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3 ex

FIELD: food industry.

SUBSTANCE: method of brown algae gel production provides for cutting raw material and washing with sea water. Then it is washed in fresh water at the temperature 25-35°С for 20-50 minutes for even swelling not less than 30%. After that the algae is demineralized by 0.5% acid solution: acetic, citric or hydrochloric, рН=2.0, with the weight ratio of the algae and solution - 1:1.5 within 1-2 hours. The algae is washed in fresh water for 10 minutes and is soaked in fresh water at the temperature 20-35°С for 30-50 minutes and change the water 1-2 times. Let the water flow down for 10-20 minutes. The algae is cut and boiled in fresh water at the temperature 75-85°С with the algae and water ratio 1:1. Then add sodium bicarbonate till рН=7.0-8.0, which is controlled while boiling for 6-10 hours at the temperature 70-80°С and mix with agitator, rotation speed is 15-25 revolutions per minute. Cool till 35-45°С and homogenize within 30 minutes. Introduce citric acid solution - 0.1% and calcium salt solution- 0.2%. Mix for 10 minutes, heat till 75°С and transform into shape suitable for storage.

EFFECT: increases storage life, increased biological accessibility and iodine digestibility, prolonged action.

12 cl, 4 ex

FIELD: food industry.

SUBSTANCE: delivery system, including hydrophobic flavoring or aromatic component or composition, encapsulated in oligomeric or polymer carrier. The hydrophobic flavoring or aromatic component or composition, not being encapsulated, are in crystal form under the pressure from 0.5x105 till 2x105 Pa and temperature from 15 till 30°С. Being incapsulated in the delivery system, they are in noncrystalline form at the specified temperature and pressure. The method, according to the first variant, provides for dispersion of components in the carrier, dispersion extrusion at the temperature higher than the component melting temperature and cooling of extrusion melt at the temperature lower than the component melt point with the speed to prevent from recrystallization. According to the second variant, the method provides for the component dispersion with the carrier water solution, dispersion heating till the temperature higher than the component melt point, dispersion homogenization and drying by spraying to prevent from recrystallization. According to the third variant, the method provides for component integration and mixing with the carrier to form homogeneous melt, melt extrusion and cutting-down, cut, grinding or obtained material spraying.

EFFECT: capability of getting delivery system providing sensory effect with significantly lower dosage.

25cl, 5 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine, cosmetology.

SUBSTANCE: invention relates to cosmetics field and applies to cosmetic and/or dermatological preparations, which contain lecithin and essential fatty acids.

EFFECT: maximal skin moistening is provided and healing of injured skin is maintained.

12 cl, 10 ex

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