Cosmetic and/or dermatological composition


FIELD: medicine, cosmetology.

SUBSTANCE: invention relates to cosmetics field and applies to cosmetic and/or dermatological preparations, which contain lecithin and essential fatty acids.

EFFECT: maximal skin moistening is provided and healing of injured skin is maintained.

12 cl, 10 ex

 

The present invention relates to cosmetic and/or dermatological preparations containing lecithin and essential fatty acids, which provide maximum hydration while strengthening the skin's metabolic processes to support the healing process of damaged skin. In addition, the preparations according to the present invention cause an extremely pleasant skin feeling.

The present invention is to provide cosmetic and/or dermatological preparations, which provide maximum hydration and accelerate the process of healing of damaged skin by strengthening the skin's metabolic processes.

This problem is solved by the technical proposal according to the independent, paragraph 1, of the claims. Other preferred features, aspects and details of the present invention arise from the dependent claims, the description and examples.

Unexpectedly, it was found that a cosmetic and/or dermatological preparation solves the specified problem, if this product contains lecithin; natural oil with a specific, preferably high content of fatty acids, especially essential fatty acids, such as sunflower oil as the lipid phase; and glycerol and/or ethylene glycol, 1,3-disappear to the diol and/or tert-butyl alcohol); propylene glycol and/or polyethylene glycol); benzyl alcohol (and/or benzylacetone and/or benzaldehyde); phenethyl alcohol (and/or 2-phenylacetate); benzyl alcohol or phenethyl alcohol and purified water.

Lecithin belongs to the group of phosphoglycerides, also known as phosphatides or phospholipids. These compounds are fat-like two triglycerides of long chain fatty acids and one group of phosphoric acid, which is connected with an ammonium group, as shown below

Lecithin is not a pure substance but a mixture of esters of various fatty acids, depending on its origin. Especially preferred is the use of lecithin from egg and/or soy. Another source is, for example, rape.

Soy lecithin is obtained by solvent extraction of soybeans ethanol, and then the lecithin purified using chromatography and subjected to hydration. Thus obtained phosphatidylcholine (lecithin) contains as fatty acid groups 80-90% by weight of stearic acid, preferably about 85% by weight of stearic acid, and 10-20% by weight palmitic acid, preferably about 15% by weight palmitic acid. Particularly suitable lecithin are Phospholipon ®80 N, and Phospholipon®90 N, available from PHOSPHOLIPID GmbH, Köln, Germany.

Lecithin finds many uses in cosmetic preparations. As a component of ointments and creams it enhances the penetration of skin active agents, and clearly increases the water-holding capacity of the stratum corneum when it is present in the gel preparations. By increasing the absorption of skin moisture decreases skin roughness. As lecithin is characterized by a very low ability to cause irritation (no effects washout). With lecithin can be prepared emulsion of the type water/oil with high water content. Lecithin is a natural antioxidant and is used as an emulsifier in the oil bath. The hydrated lecithin suitable as gelling and thickening agent in cosmetics.

Another essential component of the preparations according to the present invention are essential fatty acids that add to the product, preferably in the form of suitable oils. Such suitable oils are, for example, sunflower oil, olive oil, corn oil, Flaxseed oil, cod liver oil and fish oil.

These oils, preferably of natural origin, added to the preparations according to the present invention in amounts which TBE 3.0 to 20.0 mass%, preferably 6,0-16,0% by weight, more preferably 7 to 14% by weight, more preferably 8.0 to 12.0 mass%, more preferably 9-11% by weight and particularly preferably 10.0 percent by weight.

These oils of natural origin are chosen in accordance with the content and composition of fatty acids, including essential fatty acids, their technological suitability and usefulness in dermatological terms. Separate dermatologically active ingredients in their composition sufficiently described in the relevant technical literature. For preparations of the present invention, it is preferable to refined sunflower oil quality according to the European Pharmacopoeia. This refined sunflower oil (Helianthi annul oleum raffinatum) extracted from the seeds of Helianthus annuus C., it has a relative density 0,921 and the refractive index 1,474, a maximum acid number of 0.5 (determined with 10 g of substance), the maximum peroxide number 10, and the following fatty acid composition: 4-9% by weight palmitic acid, 1 to 7% by weight of stearic acid, 14-40% by weight of oleic acid and 48-74% by weight of linoleic acid. Another particularly suitable sunflower oil (Helianthus annuus L.) consists of 39% by weight of oleic acid, 34% by weight αlinoleic acid, 13% by weight βlinoleic acid, approximately the additional 4% by weight of glycerin, approximately 9% by weight saturated fatty acids (palmitic, stearic, arachnid and lineariloba acid), carotenoids, and lecithin. Fatty acid fraction used sunflower oil contains preferably 15-35% by weight of oleic acid, 50-72% by weight of linoleic acid. Among other things, oleic acid (oleic acid) also known as acidum oleinicum, CIS-9-octadecenoic acid, Lanovoy acid and oleic acid (oleinic acid).

Essential fatty acids (EFA). essential fatty acids) are fatty acids that cannot be synthesized in the human body and therefore must be included in the food.

Essential fatty acids are always in the CIS, but not TRANS-configuration and is characterized by two or more unsaturated carbon atoms, i.e. at least one double bond. Characteristic is the position of the first double bond in the chain of fatty acid, counting from the methyl end (omega-end). There are two types of essential fatty acids, omega-6-derived CIS-linolenic acid, and omega-3, derived α-linolenic acid. The most important groups of omega-fatty acids are omega-3-, -6 - and-9-fatty acids.

Omega-3 fatty acids include α-linolenic acid, eykozapentaenovuyu acid and docosahexaenoic acid.

Omega-irnie acid include γ -linolenic acid, linoleic acid, arachidonic acid, Delta-13-CIS, 16-CIS-dokozagexaenovu acid (22:2), Delta-11-CIS, 14-CIS-eicosa-/ecosaveology acid (20:2), and Delta-7-CIS, 10-CIS-hexadecanoyl acid (16:2).

Omega-9-fatty acids include oleic acid (Delta-9-octadecenoyl acid; 18:1), londonbuy acid (Delta-11-CIS-eicosan-/yasenovo acid; 20:1) erucic acid (Delta-13-CIS-docosanol acid; 22:1), and Neronova acid (Delta-15-CIS-tetracosanoic acid; 24:1).

The highest content of linoleic acid found in vegetable oils, such as safflower oil or Thistle oil, sunflower oil, hemp, and soybean oil, and vegetable margarine.

Triple-unsaturated α-linolenic acid (9,12,15-octadecatrienoic acid) in the greatest numbers are found in linseed oil (55%), peanut oil (14%), rapeseed oil (11%) and hemp oil (7%).

In the following table 1 shows the important omega-3 and omega-6 fatty acids, the length of their chains and the position of the double bond, as well as their sources.

Table 1
NameChain length and number of double bondsSources
Omega-3 fatty acidsȀ
Alpha-linolenic acid18:3Linseed oil, soybean oil, canola oil, margarine
Eicosapentaenoic acid (= timnodonic acid)20:5Sea fish (mackerel, salmon, herring, sardine, tuna)
Docosahexaenoic acid22:6Saltwater fish
Omega-6 fatty acids
Gamma-linolenic acid18:3Hemp oil, evening primrose oil, borage oil
Linoleic acid18:2the Thistle oil, soybean oil, sunflower oil, margarine
Arachidonic acid20:4Meat, milk (in small quantities)

Literature: P. Singer, Was sind Omega-3-Fettsäuren, Frankfurt 1994.

For preparations of the present invention, unsaturated fatty acids are preferably chosen from the group which includes oleic acid, eykozapentaenovuyu acid, timnodonic acid, docosahexaenoic acid, arachnid acid, linoleic acid, α-linolenic acid and γ-linolenic acid, and also mixtures of the aforementioned fatty acids. These blends contain mainly a mixture of the above h is simple unsaturated compounds.

According to the present invention the oil is preferably used as the component (b)which contains at least 20%, preferably at least 25%, more preferably at least 30% and particularly preferably at least 35% omega-fatty acids. Among the omega-fatty acids is especially preferred are omega-9 fatty acids, and among the omega-9 fatty acids are especially preferred is oleic acid. Additionally, for the preparation of the preparation of the present invention is especially suitable are omega-6 fatty acids, and among the omega-6 fatty acid is preferred linoleic acid.

Oils used according to the present invention as component (b)preferably contain more than 78% by weight of oleic and linoleic acids, more preferably more than 86% by weight and particularly preferably more than 93% by weight of oleic and linoleic acids. Oil used as component (b)preferably contain more than 13% by weight of oleic acid, more preferably more than 24% by weight of oleic acid and particularly preferably more than 34% by weight of oleic acid. Other preferred as component (b) oils contain more than 38% by weight of linoleic acid (α-linoleic acid + β-whether Oliva acid), preferably more than 47% by weight of linoleic acid, more preferably more than 57% by weight of linoleic acid and particularly preferably more than 67% by weight of linoleic acid. Another particularly suitable oil is sunflower oil (Helianthus annuus L.), containing 39% by weight of oleic acid, 34% by weight α-linoleic acid and 13% by weight βlinoleic acid.

As the oils are preferably used linseed oil, hempseed oil, corn oil, peanut oil, rapeseed oil, soybean oil, sunflower oil, oil of poppy seeds, safflower oil, wheat germ oil, Thistle oil from grape seed, evening primrose oil, borage seed oil, caraway oil, algae oil, fish oil, cod liver oil and/or mixtures of the aforementioned oils. Particularly suitable is sunflower oil. In addition, to ensure the necessary amount of essential fatty acids of these oils, you can add one or more essential fatty acids.

In addition to a small number of α-linolenic acid (ALA 18:3) fish oil and cod liver oil contain mostly eykozapentaenovuyu acid (EPA 20:5) and docosahexaenoic acid (DHA 22:6). Omega-3 fatty acids found in fish oil, but also in vegetable oils.

In the following table 2 shows the re is Yan fatty acid component in various oils.

Table 2
Oil typeOleic acid (C18:1) omega-9Linoleic acid (C18:2) omega-6Linolenic acid (C18:3) omega-3Eicosapentaenoic acid (C20:5) omega-3Docosahexaenoic acid (C22:6) omega-3
Olive oil7010000
Corn oil3060100
Flaxseed oil20206000
Cod liver oil2521128
Fish oil15211812

In the following tables 3, 4 and 5 lists monoenoic, polyunsaturated, and acetylenic fatty acids, which are preferably used in the present invention.

Table 3
Monorovia fatty acids
The systematic nameTrivial on the of Short form
CIS-9-tetradecenoic acidMirandolina acid14:1(n-5)
CIS-9-hexadecanoate acidpalmitoleic acid16:1(n-7)
CIS-6-octadecenoate acidpetrolina acid18:1(n-12)
CIS-9-octadecenoate acidoleic acid18:1(n-9)
CIS-11-octadecenoate acidAksenova acid18:1(n-7)
CIS-9-Aksenova acidgadolinia acid20:1(n-11)
CIS-11-Aksenova acidGodunova acid20:1(n-9)
CIS-13-docosanoate aciderucic acid22:1(n-9)
CIS-15-tetracosanoic acidNeronova acid24:1(n-9)
TRANS-9-octadecenoate acidelaidic acid
TRANS-11-octadecenoate acidTRANS-Aksenova acid
TRANS-3-hexadecanone acidTRANS-16:1 n-13

Table 4
Polyunsaturated fatty acids
The systematic nameTrivial nameShort form
9,12-octadecadienoic acidlinoleic acid18:2(n-6)
6,9,12-octadecatrienoic acidγ-linoleic acid18:3(n-6)
8,11,14-eicosatrienoic aciddi-Homo - γ-linolenic acid20:3(n-6)
5,8,11,14-eicosatetraenoic acidarachidonic acid20:4(n-6)
7,10,13,16-docosatetraenoic acid-22:4(n-6)
4,7,10,13,16-docosapentaenoic acid-22:5(n-6)
9,12,15-octadecatrienoic acidα-linolenic acid18:3(n-3)
6,9,12,15-octadecatetraenoic acidstereonova acid18:4(n-3)
8,11,14,17-eicosatetraenoic acid-20:4(n-3)
5,8,11,14,17-eicosapentaenoic acidEPA20:5(n-3)
7,10,13,16,19-docosapentaenoic acidDPA22:5(n-3)
4,7,10,13,16,19-Doko is Alekseeva acid DHA22:6(n-3)
5,8,11-eicosatrienoic acidMedova acid (mead acid)20:3(n-9)
CIS-9, TRANS-11,TRANS-13-aleocharinae acid
TRANS-8,TRANS-10,CIS-12-kalentieva acid
CIS-9,TRANS-11,CIS-13 3-kataleena acid
4,7,9,11,13,16,19-dokozageksaenovoy acidtallahatta acid
taxonomy acidall CIS-5,9-18:2
PYRANOVA acidall-CIS-5,9,12-18:3
cladonema acidall CIS-5,11,14-20:3

Along with the essential fatty acids in the preparation of the present invention can be added fatty acids, non-essential, or TRANS-fatty acids, and the above percentage by weight of essential fatty acids should not fall below at least 30% by weight, preferably 40% by weight and especially at least 50% by mass.

The maximum amount of essential fatty acids should not exceed 25 grams per 100 grams of the drug.

Table 5
Acetylenic fatty acids
The systematic nameTrivial name
6-octadecenoate acidterinova acid
TRANS-11-octadecene-9-andnew acidsantalina or ximenia acid
9-octadecenoate acidstaronova acid
6 octadecene-9-andnew acid6,9-octadecenoate acid
TRANS-10-heptadecene-8-andnew acidprolinnova acid
9 octadecene-12-new acidgrebenyova acid
TRANS-7,TRANS-11-octadecadiene-9-andnew acidgastrinoma acid
TRANS-8,TRANS-10-octadecadiene-12-new acid-
5,8,11,14-eicosatetraenoic acidETYA

Cosmetic and/or dermatological preparations according to the present invention additionally contain glycerin in the form of an 85%solution in water, propylene glycol, respectively, the polyethylene glycol, as agent, providing a consistent, benzyl alcohol, benzylacetone and/or benzaldehyde, and phenethyl alcohol and/or 2-Hairdryer shall latitat. The water content in the glycerol can be up to 20%. Instead of glycerin you can use a combination of glycerol and ethylene glycol, 1,3-propane diol, tert-butyl alcohol and/or alcohols with boiling points greater than 125°C, preferably above 150°and preferably dialami or trioligy.

Benzyl alcohol, benzylacetone and/or benzaldehyde add as air permeability to enhance metabolic processes in the skin, as well as stabilizing agents for the drug.

Phenethyl alcohol and 2-phenylacetate also serve as air permeability to enhance metabolic processes in the skin, and also stabilize the drug.

Mainly benzyl alcohol, and phenethyl alcohol additionally lead to unexpected synergistic effect between the components of the cosmetic and/or dermatological preparation according to the present invention, the consequence of which is that in the case of a very good supply skin moisture metabolic processes in the skin are stimulated and strengthened and, in addition, is maintaining the lipid barrier. Thus, the preparations according to the present invention are suitable for the treatment of damaged skin and wrinkles in the case of longer use. Still the way proposed remedies, which are suitable not only for dermatologic use in the case of, for example, acne, neurodermatitis and/or dermatitis, but at the same time cause cosmetic effects, such as wrinkles, by empowering amplification and regeneration of the lipid barrier, and/or the stimulation and strengthening the skin's metabolic processes. Especially beneficial is the addition of benzyl alcohol and/or phenethyl alcohol, which in addition to the synergistic effect also contribute to a noticeable increase in viscosity. This is a significant spontaneous increase in viscosity, achieved mainly due to the benzyl alcohol is essential for the formation matrix or gel frame and, consequently, for dermatological/cosmetic functions of the preparations according to the present invention. These two components, and especially benzyl alcohol seems to play an important role in the formation of the skeleton. By adding these components significantly increases the supply skin with moisture. Another important ingredient is propylene glycol, which is preferably used in percentage amounts by weight, comprising preferably at least 8% by weight, more preferably 9 mass%, 10 mass%, 11% by weight, 12% by weight, 13% by mass, and is particularly preferably 14% by weight. Function propylene glycol in education special skeleton preparations of the present invention is not yet clear, but the effect on the consistency of the drug can be reliably confirmed.

Cosmetic and/or dermatological preparations according to the present invention contain lecithin in the amount of 0.5 to 20.0% by weight, preferably 2.0 to 10.0 percent by weight, more preferably from 3.0 to 5.0% by mass, and particularly preferably to 4.0% by mass.

Glycerin is used in the form of an 85%solution in water in the amount of 0.5 to about 30.0% by weight, preferably from 3.0 to 10.0 mass%, more preferably of 5.0-7.0% by weight, more preferably 4.5 to 6.0 percent by weight and especially preferably 5% by mass. Ethylene glycol,1,3-propandiol, tert-butyl alcohol or other diols or trioli or alcohols with boiling points greater than 125°150°With, respectively, add instead of glycerin or together with glycerin in such quantities that have not been exceeded or under the above-mentioned ranges.

The amount of propylene glycol and/or polyethylene glycol is 0.5 to 50.0% by weight, preferably from 6 to 35% by weight, 7-30% by weight, 7.5 to 28% by weight, 8-26% by weight, 8,5-25% by weight, 9-24% by weight, 9.5 to 23% by weight, more preferably 10.0 to 22.0 percent by weight, even more preferably 11 to 21 mass%, 12-20% by weight, 13-19% by weight, even more preferably 14,0-18,0% by weight, still more is preferably 15-17% by mass, and particularly preferably 16,0% by weight. In addition, preferably, if the above percentage by weight is only propylene glycol, i.e., the polyethylene glycol is not present. Thus, favorable are only a small amount of polyethylene glycol, a maximum of up to 30% of the percentage amount by weight of propylene glycol, preferably a maximum of up to 20%, more preferably a maximum of up to 20%, more preferably a maximum of up to 15% and especially preferably a maximum of up to 10% of the percentage amount by weight of propylene glycol.

Benzyloxy alcohol, benzylacetone and/or benzaldehyde is used in an amount of 0.1 to 15.0% by weight, preferably from 1.0 to 5.0% by weight, more preferably of 2.0 to 4.0% by mass, and particularly preferably to 3.0% by mass.

Cosmetic and/or dermatological preparations according to the present invention contain phenethyl alcohol and/or 2-phenyl acetate in an amount of 0.1 to 15.0% by weight, preferably of 0.2 to 5.0% by weight, more preferably 0.3 to 1.5% by weight and especially preferably 0.5% by mass.

The above components are mixed with the same amount of purified water to Supplement the product up to 100% by mass.

Particularly preferred is the preparation of the following components: lecithin, natural oil with a certain amount of essential fatty is acid, such as sunflower oil and glycerin, propylene glycol, benzyl alcohol, phenethyl alcohol and purified water.

The compositions of the present invention can additionally be mixed with conventional flavoring agents, respectively, perfumes, dyes, preservatives, agents that increase the viscosity and/or UV filters. These additives serve mainly to increase the light fastness and stability of colour and flavour drugs, as well as their shelf life, or to maintain consistency, respectively. Such additives are generally present in the preparation in an amount of not more than 10% by weight, preferably 8% by mass, more preferably 6% by mass, and particularly preferably 4% by mass.

Cosmetic and/or dermatological preparations according to the present invention can be applied successfully to the treatment of all forms of skin disorders ranging from impure skin to damaged skin. Under unclean - damaged skin implies, for example, all forms of acne, neurodermatitis or atypical dermatitis.

Cosmetic and/or dermatological preparations involve mainly skin creams, skin lotions, lotions, ointments, oils, and balms, and all other preparations suitable for local application.

The following examples explain the present invention does not limit the Wai.

EXAMPLES

Example 1

No.ComponentsThe amount(% by weight)
1lecithin from eggs4,0
2oil of natural origin = sunflower oil10,0
3glycerin5,0
4propylene glycol16,0
5benzyl alcohol : 3,0
6phenethyl alcohol0,5
7purified water100

Example 2

No.ComponentsThe amount (% by weight)
1lecithin from eggs4,5
2oil of natural origin = sunflower oilto 12.0
3glycerin4,5
4propylene glycol14,0
5benzyl alcohol : 2,5
6phenethyl alcohol0,8
7purified water100

Example 3

No.ComponentsThe amount (% by weight)
1lecithin from soybeans3,5
2oil of natural origin = sunflower oil8,0
3glycerin6,0
4propylene glycol18,0
5benzyl alcohol : 3,5
62-phenylacetate0,6
7purified water100

Example 4

No.ComponentsThe amount (% by weight)
1lecithin from eggs15,0
2oil of natural origin = sunflower oil15,0
3glycerin5,0
4the polyethylene glycol16,0
5benzylacetone3,0
6phenethyl alcohol0,5
7purified water100

Primer

No.ComponentsThe amount (% by weight)
1lecithin from eggs10,5
2oil of natural origin = sunflower oil18,0
3glycerin4,5
4propylene glycol14,0
5phenethyl alcohol3,0
6purified water100

Example 6

No.ComponentsThe amount (% by weight)
1lecithin from soybeans8,5
2oil of natural origin = sunflower oil20,0
3glycerin3,0
4tert-butyl alcohol : 3,0
5propylene glycol18,0
6benzyl alcohol : 3,5
7phenethyl alcohol0,6
8purified water100

Example 7

No.ComponentsThe amount (% by weight)
1lecithin from eggs10,5
2oil of natural origin = sunflower oil18,0
3glycerin4,5
4propylene glycol18,0
5the polyethylene glycol1,5
6benzyl alcohol : 6,0
7purified water100

Example 8

No.ComponentsThe amount (% by weight)
1lecithin from eggs10,5
2oil of natural origin = sunflower oil18,0
3ethylene glycol4,5
4propylene glycol22,0
5benzyl alcohol : 5,0
6Benzylacetone2,0
7purified water100

Example 9

No.ComponentsThe amount (% by weight)1lecithin from rapeseed10,52oil of natural origin = sunflower oil18,031,3-propandiol4,54propylene glycol19,05benzyl alcohol : 0,86benzylacetone3,67benzaldehyde1,18purified water100

Example 10

Confirmation increasing the viscosity of the

A suspension of 100 g of lecithin (phosphatidylcholine 80 N, Lipoid Al.) 900 g of water were mixed with 20 g of benzyl alcohol at 30-40°C. Before the addition of benzyl alcohol viscosity was approximately 2180 MPa· (Haake RV/7 (Brookfield) of the immersed body R3, 30.min, 38°), but after adding benzyl alcohol she was 54790 MPa· (submersible body R5, 4 vol./min, 34°).

The readings were made every 2 minutes.

The increase in viscosity is constant.

A composition according to the invention

Composition:

1hydrogenated LEC is tin 4,0%
2propylene glycol16,0%
3glycerol 85%5,0%
4sunflower oil, refined10,0%
5benzyl alcohol : 3,0%
6phenethyl alcohol0,5%
7antioxidant0,5%
8perfume0,3%
9water60,7%
100%

Obtaining phase 1:

The water is heated and at 40-45°add the lecithin. The mixture is stirred and then heated to 70°C. If the lecithin does not dissolve completely, carry out short-term stage homogenization.

Obtaining phase 2:

Propylene glycol and/or polyethylene glycol), 85%glycerol (ethylene glycol, 1,3-propandiol and/or tert-butyl alcohol), sunflower oil (refined) and the antioxidant are mixed and heated to 70°C.

Mixing of phases 1 and 2

Phase 1 and phase 2 are mixed together and stirred for 15-20 minutes. If two phases are mixed enough, carry out short-term stage homogenization.

Cooling and addition of benzyl alcohol (and/or phenethyl which perta) and odorants

The mixture is cooled. At 35°add benzyl alcohol, phenethyl alcohol, and possibly the odorant and/or antioxidants. The mixture is stirred for 15 minutes.

The bottling of the final product

The masses poured into 50 ml containers. The containers are tightly closed with aluminum foil.

Packaging

The containers are labeled, causing the date of manufacture and batch number, and Packed in a folding box designed for this purpose.

Method of test the roughness of the skin

To participate in the research test the roughness of the skin allowed only patients with healthy skin. MLV-cosmetics according to the invention were applied to the patient's skin two times a day. To obtain quantitative results the patient's skin was assessed using the device PRIMOS (Phaseshift Rapid In vivo Measurement Of Skin (Rapid in vivo measurement of skin on the basis of the phase shift)), which determines the 3D profile of the patient's skin.

PRIMOS is a three-dimensional optical measurement method, wherein on the surface of the skin induce optical bands, which then detects camera with CCD (device CCD) chip. This can be detected even minimal differences in the height of the skin surface, which is a measure of the roughness of the skin. Optical band projected onto the surface of the skin, are rejected due to the difference in height and it is off the work can be defined digital Micromirror projectors that allows to determine the minimum difference in height.

Usually to measure take the area of the skin surface 10×8 mm2, which is divided into 640×480 pixels.

The measurement results obtained with MLV-cosmetics

Using data obtained in the experiment PRIMOS, it is possible to determine structural changes in the skin, in particular the reduction of most small skin folds. The experiments showed that MLV-cosmetics is able to reduce skin folds on average 23,71%. This test was performed on 24 patients within 4 weeks. The results of this test are presented in table 6 below.

td align="center"> 107,1
Table 6
to1)after1)otism %
patient No. 1141117,823,219,6943973
patient No. 2145, 2mmto 120.324,920,6982544
patient No. 3212,6164,947,728,9266222
patient No. 4154,113123,117,6335878
patient No. 5162,9137,725,218,3006536
patient No. 6 164,2149,314,99,97990623
patient No. 7208,4157,550,932,3174603
patient No. 8207,2143,863,444,0890125
patient No. 9204,5154,849,732,1059432
patient No. 10180,8144,136,725,4684247
patient No. 11196,915145,930,397351
patient No. 12155,9135,92014,7167035
patient No. 13153,3to 124.428,923,2315113
patient No. 14137,2byr111.425,823,1597846
patient No. 15118,799,8218,8818,9140453
patient No. 16158,8125,4the 33.426,6347687
patient No. 17145,5or 115.130,426,4118158
patient No. 18127,12018,6741363
patient No. 19139,4110,42926,2681159
patient No. 20107,592,1915,3116,6070073
161,06129,695531,364523,7114751
1) "before" and "after" represents the average depth of one folds five neighboring areas of the skin

Experimental data show that there has been a significant decrease in skin folds. In none of the cases was not observed any unwanted skin reactions or irritation of the skin. Accordingly, MLV-cosmetics was evaluated by an independent German Institute of dermatological testing "DERMATEST" as "very good."

The final report of the independent German Institute for dermatological testing "DERMATEST" after conducting a test on the roughness of the skin, was that from a dermatological point of view MLV-cosmetics very well seen in the test patients, and from a clinical point of view, was able to reduce roughness of the skin for 4 weeks on 23,71% according to the test on the rough surface of the TB skin carried out according to DIN norm 4768.

Allergic skin test

The test was conducted at the German Institute for dermatological testing "DERMATEST". The objective of this test was to study the irritant and/or allergic hypersensitivity to MLV-cosmetics.

MLV-cosmetics were applied to a piece of filter paper was placed on the impermeable layer and fixed to the skin with adhesive tape. The patch was left in place for 24 hours and then removed. Conducted dermatological research. The second and third dermatological study was performed after 48 and 72 hours. The study involved 30 people.

The result: under the conditions allergic skin samples was not observed neither primary irritation or allergic hypersensitivity.

Epicutaneous test

This test is similar to allergic skin test but is in sensitized patients, which typically show an allergic reaction to at least one ingredient MLV cosmetics.

MLV-cosmetics were applied to a piece of filter paper was placed on the impermeable layer and fixed to the skin with adhesive tape. The patch was left in place for 24 hours and then removed. Conducted dermatological research. The second and third dermatological research wire is whether after 48 and 72 hours. The study involved 30 people.

The result: under the conditions epicutaneous test was not observed neither primary irritation or allergic hypersensitivity.

None of the thirty-tested patients had a positive reaction after 24, 48 and 72 hours.

Cashnetusa and/or dermatological composition for maximum hydration, enhance the healing process of damaged skin and create a pleasant skin sensation, containing the following components, wt%:

and) lecithinof 0.5 to 20.0
b) oil with a high content
essential fatty acids3,0-20,0
V) glycerol, ethylene glycol
1,3-propandiol and/or tributyl alcohol0.5 to about 30.0
g) propylene glycol and/or polyethylene glycolfrom 0.5 to 50.0
d) benzyl alcohol and/or phenethyl alcoholof 0.1 to 15.0
(e) purified water100

2. Cosmetic and/or dermatological composition according to claim 1, containing the following components, wt%:

and) lecithinof 0.5 to 20.0
b) the oil is with a high content
essential fatty acids3,0-20,0
V) glycerol0.5 to about 30.0
g) propylene glycolfrom 0.5 to 50.0
d) benzyl alcohol and/or phenethyl alcoholof 0.1 to 15.0
(e) purified water100

3. Cosmetic and/or dermatological composition according to claim 1, additionally containing the following components, wt%:

g) benzylacetone and/or benzaldehydeof 0.1 to 15.0
C) 2-phenylacetateof 0.1 to 15.0

4. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where lecithin derived from egg and/or soy.

5. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where the oil of natural origin has a content of essential fatty acids, at least 30% by weight, preferably 40% by mass, and particularly preferably at least 50 mass%.

6. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where essential fatty acids belong to the omega-fatty acids, preferably oleic acid and linoleic acid.

7. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where the lecithin content is carried out in a quantity by weight, preferably 2.0 to 10.0 percent by weight, more preferably from 3.0 to 5.0% by mass, and particularly preferably about 4.0% by mass.

8. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where the oil of natural origin is contained in the number 6,0-16,0% by weight, preferably 8.0 to 12.0 mass%, and particularly to 10.0% by mass.

9. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, which contains glycerin in the form of an 85%aqueous solution, ethylene glycol, 1,3-propandiol and/or tert-butyl alcohol in the amount of 3.0 to 10.0 mass%, more preferably of 5.0-7.0% by weight and especially preferably of 5.0% by mass.

10. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where propylene glycol and/or polyethylene glycol is contained in an amount of 10.0 to 22.0% by weight, preferably 14,0-18,0% by weight and especially preferably of 16.0% by mass.

11. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where benzyl alcohol, benzylacetone and/or benzaldehyde is contained in the amount of 1.0 to 5.0% by weight, preferably of 2.0 to 4.0% by mass, and particularly preferably 3.0 percent by weight.

12. Cosmetic and/or dermatological composition according to any one of claims 1 to 3, where phenethyl alcohol and/or 2-phenyl acetate is contained in the amount of 0.2 to 5.0% by weight, preferably 0.3 to 1.5% by weight and especially preferably 0.5% by mass.



 

Same patents:

FIELD: medicine, stomatology.

SUBSTANCE: composition contains about 10 to 13 weight percent of water and abrasive low-structured precipitated silica dioxide, which has the refraction index about 1.439 to 1.450, index of lipid uptake about 90 to 120 mL/100g, optical transmission more than 60% and Brass Einlehner abrasion value less than 5 mg loss/100 000 rev. In addition, dental care agent has opacity index less than 50 and RDA about 50 to 200, refraction index about 1.439 to 1.450.

EFFECT: abrasive efficiency is increased.

7 cl, 6 tbl, 2 ex, 1 dwg

FIELD: personal hygiene commodities.

SUBSTANCE: invention relates to aqueous fluid compositions and aims at obtaining fluid non-Newton on shear liquefiable composition suitable for use in personal hygiene commodities, which composition is capable of slurring water-insoluble particles and manifests stability under freezing/thawing conditions. Invention provides fluid composition containing, based on the mass of composition, at least one anionic surfactant, 5-30%, at least one alkanolamine, 0.1-10%, at least one electrolyte, and water. Composition may further contain one or several supplemental surfactants. Composition of invention has layered liquid-crystalline structure, has non-Newton on shear liquefaction property, and ability of slurring water-insoluble particles or partially insoluble components, while being stable in at least one freezing/thawing cycle. Proposed are also a method of preparing indicated composition or stable multiphase composition based thereon.

EFFECT: extended choice of practically useful on shear-liquefiable compositions.

54 cl, 11 tbl, 5 ex

FIELD: personal hygiene commodities.

SUBSTANCE: invention relates to aqueous fluid compositions and aims at obtaining fluid non-Newton on shear liquefiable composition suitable for use in personal hygiene commodities, which composition is capable of slurring water-insoluble particles and manifests stability under freezing/thawing conditions. Invention provides fluid composition containing, based on the mass of composition, at least one anionic surfactant, 5-30%, at least one alkanolamine, 0.1-10%, at least one electrolyte, and water. Composition may further contain one or several supplemental surfactants. Composition of invention has layered liquid-crystalline structure, has non-Newton on shear liquefaction property, and ability of slurring water-insoluble particles or partially insoluble components, while being stable in at least one freezing/thawing cycle. Proposed are also a method of preparing indicated composition or stable multiphase composition based thereon.

EFFECT: extended choice of practically useful on shear-liquefiable compositions.

54 cl, 11 tbl, 5 ex

FIELD: organic chemistry, medicine, pharmacy, cosmetology.

SUBSTANCE: invention relates to novel biphenylmethylthiazolidinedions of the general formula (I): , their salts, and to their optical and geometrical isomers possessing agonistic activity with respect to PPARγ receptors, to pharmaceutical and cosmetic compositions based on thereof, and to their using for preparing composition used in treatment of different cutaneous diseases. In compound of the formula (I) R1 means radical of the following formula (a): or (b): ; R2 and R3 mean hydrogen atom; X means binding groups showing the following structures: -CH2-N(R8)-CO-, -N(R8)-CO-N(R9)- that can be read from left to right or vice versa; R4 means phenyl substituted with group R10, pyrrolyl, naphthyl, biphenyl, indenyl, benzothienyl and all these groups can be mono- or di-substituted with group R11 and/or R12, group -(CH2)n-(CO)qR13, adamantyl, cyclopentylethyl, group -(CH2)n-O-R13; R5 means hydroxyl or alkoxyl with 1-19 carbon atoms; R6 means group -OR14. Values R8, R9, R10, R11, R12, R13, n and q are given in the invention claim.

EFFECT: valuable medicinal properties of compounds.

25 cl, 2 dwg, 37 ex

FIELD: organic chemistry, medicine, pharmacy, cosmetology.

SUBSTANCE: invention relates to novel biphenylmethylthiazolidinedions of the general formula (I): , their salts, and to their optical and geometrical isomers possessing agonistic activity with respect to PPARγ receptors, to pharmaceutical and cosmetic compositions based on thereof, and to their using for preparing composition used in treatment of different cutaneous diseases. In compound of the formula (I) R1 means radical of the following formula (a): or (b): ; R2 and R3 mean hydrogen atom; X means binding groups showing the following structures: -CH2-N(R8)-CO-, -N(R8)-CO-N(R9)- that can be read from left to right or vice versa; R4 means phenyl substituted with group R10, pyrrolyl, naphthyl, biphenyl, indenyl, benzothienyl and all these groups can be mono- or di-substituted with group R11 and/or R12, group -(CH2)n-(CO)qR13, adamantyl, cyclopentylethyl, group -(CH2)n-O-R13; R5 means hydroxyl or alkoxyl with 1-19 carbon atoms; R6 means group -OR14. Values R8, R9, R10, R11, R12, R13, n and q are given in the invention claim.

EFFECT: valuable medicinal properties of compounds.

25 cl, 2 dwg, 37 ex

FIELD: medicine, dermatology.

SUBSTANCE: the present innovation deals with applying the preparation to prevent contact allergic dermatitis induced with salts of nickel or other metals under conditions of nickel plating at galvanic manufacturing. The preparation for preventing contact allergic dermatitis induced with nickel salts contains natural zeolite (for example, from Kholinskoe origin at isolated fraction being less than 0.25 mm). It consists of zeolite dispersed in the foundation out of starchy gel at the following ratio of the components, weight%: zeolite 26.0-29.0; 2.0-4.0 weight% starchy gel - the rest. The preparation declared is of good sorption properties, covers the skin steadily and is retained well upon it; it is easily removed with water that in combination enables to decrease the quantity of nickel ions in surface and deep cutaneous layers and, thus, prevents the development of contact dermatosis.

EFFECT: higher efficiency of prophylaxis.

3 ex, 1 tbl

FIELD: medicine, stomatology.

SUBSTANCE: the present innovation deals with taking care of oral cavity. The suggested composition includes 0.01-20 weight% of finely divided natural chalk and about 5-60 weight% perlite. The innovation produces improved abrasive result.

EFFECT: higher efficiency.

3 cl, 2 ex

FIELD: cosmetology.

SUBSTANCE: the present innovation refers to cosmetic preparations and deals with antiperspirants and deodorants. Emulsion composition of water/salt of antiperspirant contains dissolved astringent salt chosen out of the salts of aluminum, zirconium and mixed salts of aluminum-zirconium, an emulsifying agent and, in separate phase, a polymer containing the groups of Brönsted acids. The suggested composition enables to decrease perspiration.

EFFECT: higher efficiency.

9 cl, 8 ex, 6 tbl

FIELD: medicine, stomatology.

SUBSTANCE: invention discloses a substrate containing about from 5 wt.-% to 30 wt.-% of added gum. Also, invention discloses a method for preparing a substrate with added or applied gum. Also, invention involves agent for teeth care and comprising a gum-treated substrate and one or more components chosen from group consisting of wetting agents, abrasives, thickening agents, binding agents, stabilizing agents, bactericidal agents, fluorides, sweetening agents and surfactants. Invention provides delayed increasing viscosity in addition of substrate to the personal hygiene composition, such as dental paste.

EFFECT: improved method of addition.

13 cl, 4 tbl, 10 ex

FIELD: industrial hygiene.

SUBSTANCE: invention relates to protection of hands skin against different pollutions. Cream for protection of worker hands skin against unfavorable industrial pollutions (industrial oils, consistent lubricants, graphite, cement, ground dust and carbon black) comprises soap, glycerol, kaolin, preserving agent, perfume and water and, additionally, it comprises higher fatty acids, incomplete fatty acid glycerides, triglycerides, higher fatty alcohols, low-molecular organic acids, propylene glycol or butylenes glycol wherein these components are taken in the definite quantitative ratio. Proposed cream shows light texture, near physiological pH value, it is applied on hands easily, dried for 20-30 s, form a protective film resistant to sweat and short-time effect of water, prolonged storage time in the range of temperature from -20°C to +30°C without separating and water separation and keeps multiple freezing-thawing. After using this cream skin of hands shows softness, silky-like, without dryness and constriction and doesn't require additional care with using wetting and/or nutrient creams.

EFFECT: improved and valuable properties of cream.

7 cl, 2 tbl

FIELD: medicine, stomatology.

SUBSTANCE: composition contains about 10 to 13 weight percent of water and abrasive low-structured precipitated silica dioxide, which has the refraction index about 1.439 to 1.450, index of lipid uptake about 90 to 120 mL/100g, optical transmission more than 60% and Brass Einlehner abrasion value less than 5 mg loss/100 000 rev. In addition, dental care agent has opacity index less than 50 and RDA about 50 to 200, refraction index about 1.439 to 1.450.

EFFECT: abrasive efficiency is increased.

7 cl, 6 tbl, 2 ex, 1 dwg

FIELD: medicine; stomatology.

SUBSTANCE: composition for treatment of inflammatory process in paradontium contains metronidazole, dimexid, water, in addition, it contains silver ions received by electrolytic diffusion from silver electrode, gelling agent - sodium carboxymethyl cellulose, glycerin, methylene-blue stain, and all ingredients are taken in particular quantity.

EFFECT: composition reduces treatment period and has a bactericidal activity.

3 ex

FIELD: food industry.

SUBSTANCE: method of brown algae gel production provides for cutting raw material and washing with sea water. Then it is washed in fresh water at the temperature 25-35°С for 20-50 minutes for even swelling not less than 30%. After that the algae is demineralized by 0.5% acid solution: acetic, citric or hydrochloric, рН=2.0, with the weight ratio of the algae and solution - 1:1.5 within 1-2 hours. The algae is washed in fresh water for 10 minutes and is soaked in fresh water at the temperature 20-35°С for 30-50 minutes and change the water 1-2 times. Let the water flow down for 10-20 minutes. The algae is cut and boiled in fresh water at the temperature 75-85°С with the algae and water ratio 1:1. Then add sodium bicarbonate till рН=7.0-8.0, which is controlled while boiling for 6-10 hours at the temperature 70-80°С and mix with agitator, rotation speed is 15-25 revolutions per minute. Cool till 35-45°С and homogenize within 30 minutes. Introduce citric acid solution - 0.1% and calcium salt solution- 0.2%. Mix for 10 minutes, heat till 75°С and transform into shape suitable for storage.

EFFECT: increases storage life, increased biological accessibility and iodine digestibility, prolonged action.

12 cl, 4 ex

FIELD: food industry.

SUBSTANCE: delivery system, including hydrophobic flavoring or aromatic component or composition, encapsulated in oligomeric or polymer carrier. The hydrophobic flavoring or aromatic component or composition, not being encapsulated, are in crystal form under the pressure from 0.5x105 till 2x105 Pa and temperature from 15 till 30°С. Being incapsulated in the delivery system, they are in noncrystalline form at the specified temperature and pressure. The method, according to the first variant, provides for dispersion of components in the carrier, dispersion extrusion at the temperature higher than the component melting temperature and cooling of extrusion melt at the temperature lower than the component melt point with the speed to prevent from recrystallization. According to the second variant, the method provides for the component dispersion with the carrier water solution, dispersion heating till the temperature higher than the component melt point, dispersion homogenization and drying by spraying to prevent from recrystallization. According to the third variant, the method provides for component integration and mixing with the carrier to form homogeneous melt, melt extrusion and cutting-down, cut, grinding or obtained material spraying.

EFFECT: capability of getting delivery system providing sensory effect with significantly lower dosage.

25cl, 5 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine, stomatology.

SUBSTANCE: composition contains about 10 to 13 weight percent of water and abrasive low-structured precipitated silica dioxide, which has the refraction index about 1.439 to 1.450, index of lipid uptake about 90 to 120 mL/100g, optical transmission more than 60% and Brass Einlehner abrasion value less than 5 mg loss/100 000 rev. In addition, dental care agent has opacity index less than 50 and RDA about 50 to 200, refraction index about 1.439 to 1.450.

EFFECT: abrasive efficiency is increased.

7 cl, 6 tbl, 2 ex, 1 dwg

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