Abrasive compositions for transparent tooth paste

FIELD: medicine, stomatology.

SUBSTANCE: composition contains about 10 to 13 weight percent of water and abrasive low-structured precipitated silica dioxide, which has the refraction index about 1.439 to 1.450, index of lipid uptake about 90 to 120 mL/100g, optical transmission more than 60% and Brass Einlehner abrasion value less than 5 mg loss/100 000 rev. In addition, dental care agent has opacity index less than 50 and RDA about 50 to 200, refraction index about 1.439 to 1.450.

EFFECT: abrasive efficiency is increased.

7 cl, 6 tbl, 2 ex, 1 dwg

 

This application is a partial continuation of application for U.S. patent No. 10/029510, filed December 21, 2001, entitled "Compositions funds for the care of teeth."

The level of technology

Precipitated silica is used in various industrial products, ranging from cosmetics and food products, to industrial coatings and elastomeric materials, for example, for automobile tires. Silicon dioxide is used, in particular, means for care of teeth (for example, in toothpastes), where it acts as an abrasive material and a thickener. With such a wide range of functional properties, and also because silicon dioxide compared to other abrasive products for teeth (especially alumina or calcium carbonate) has a relatively high compatibility with active ingredients, such as fluoride, creators of funds for care of teeth and tooth pastes would love to include it in the composition of these products.

However, to enable the abrasive silicon dioxide in a transparent means for care of the teeth is difficult. Produced by transparent toothpastes become in recent years more and more popular due to the increase of interest to him some part of consumers and due to the fact that it allows manufacturers to make Holy what their products more distinctive character. To produce containing silicon dioxide transparent toothpaste, it is necessary that the refractive index of silicon dioxide closely match the refractive index of the basics of toothpaste and to silicon dioxide had a high degree of light transmission. In addition, to provide advantages in terms of oral hygiene silicon dioxide has sufficiently high abrasive properties, providing cleaning of the surface of the teeth with his inclusion in the composition of the preparations for the care of teeth. Finally, when a transparent way to care for teeth silicon dioxide must provide sufficient viscosity such funds for the care of teeth, so that it is transparent tool was convenient for consumer use.

Since the refractive index of silicon dioxide must match the refractive index of the basics of toothpaste that this toothpaste was transparent, usually the water content in toothpaste should be maintained at a relatively low level. Water generally has a much lower refractive index than silicon dioxide, glycerin and sorbitol: commercially available precipitated silica have a refractive index from about 1,438 up to 1,451, whereas water has a refractive index 1,132, 98% glycerin has a coefficient p is elmline 1,472, and 70% sorbitol has a refractive index 1,456. If the water content in toothpaste is increased, the refractive index of the toothpaste is reduced and, thus, to make the refractive index of silicon dioxide match the refractive index of toothpaste, the water content in toothpaste should be minimized. This is undesirable, since in General water is the least expensive component of the members of toothpaste and a decrease in water content, as a rule, is compensated by the increase in the content of humectants (which are rather expensive). So the reduction in water content will cause a corresponding increase in the cost of toothpaste (per unit of output).

Moreover, abrasive silicon dioxide is an essential ingredient of toothpaste in order to achieve effective cleaning of the tooth surface. Unfortunately, adding abrasive silicon dioxide can reduce the transparency of the resulting toothpaste due to its lower degree of transmittance and high refractive index. Because of the high refractive index of silicon dioxide is often necessary to reduce the water content, increasing at the same time, the content of humidifiers, which leads to a significant increase in the cost of the final product.

Another consideration regarding the manufacture of transparent toothpaste concerns the viscosity of the toothpaste. Most of the produced toothpastes has a viscosity between 250000 JV and 1000000 SP. If the viscosity is less than 250000 JV, toothpaste is very liquid and has poor strength properties, so that flows between the bristles of the toothbrush and dripping, flowing down with a toothbrush. If the viscosity of more than 1,000,000 centipoise, toothpaste difficult to squeeze from the tube and it is unlikely that such pasta is well distributed in the mouth while brushing.

Typically, the viscosity of the toothpaste regulate through the use of silicon dioxide or gel-forming means, such as polysaccharides or carboxymethylcellulose. Gelling agent is usually present in low concentrations of about 0.1 to 1.5 wt.% on the composition of the toothpaste, because a high concentration of gel-forming means can have undesirable effects on the product distribution, rheological characteristics and clumping. Because the gel-forming tool can only be used at such low concentrations, in the overwhelming number of formulations of toothpastes increase the viscosity values until a satisfactory level is achieved through silicon dioxide as a component. But, if you use silicon dioxide molecular structure or with a low grade is Yu absorption of fats, then, to provide the desired level of viscosity of toothpaste you need to use silicon dioxide in large quantities. On the contrary, silicon dioxide with a more macromolecular structure provides a good level of viscosity, but does not yield the desired abrasive effect for cleaning teeth.

From the foregoing it is clear that there is an urgent need for compositions containing silicon dioxide, which not only would provide a good abrasive effect and a high degree of absorption of fats (by providing good viscosity), but also had good optical properties, such as high bandwidth and relatively low refractive index, so that the inclusion of silica in the composition of the transparent toothpaste, it would have a relatively high water content.

Disclosure of inventions

The invention relates to the composition of the amorphous precipitated silicon dioxide, and the composition of the silicon dioxide has a refractive index from about 1,439 up to 1,450, the light transmission of more than 60%, the rate of grinding on Brass Einlehner less than about 5 mg loss/100,000 revolutions.

The invention also relates to means for the care of teeth, including pre-cooked mixture (premix) without silicon dioxide, and the mixture has a refractive index from about 1,to 1,450. Means for care of teeth also contains from about 0.01 to about 35 wt.% abrasive silicon dioxide and has a RDA more than about 50, a measure of the turbidity of less than about 50 and a viscosity of more than about 425000 SP.

The invention also relates to a method of obtaining funds for the care of teeth, comprising a stage of mixing the premix containing no silicon dioxide and having a refractive index from about 1,439 up to 1,450, and mixing the silica with the premix to obtain funds for the care of teeth with RDA more than approximately 50.

Brief description of drawing

The above summary of the invention and following detailed description of preferred embodiments of the invention will become more clear when considered together with the accompanying graphic material. Note, however, that the invention is not limited to the exact physical correlations, shown in graphical form.

The drawing shows a graph showing the relationship between the degree of light transmission ("% transmittance") depending on the refractive index of the precipitated silica obtained according to the present invention, in comparison with the known from the prior art abrasives based on the silica.

The implementation of the invention

All frequent the, percentages and ratios used herein are expressed as weight unless otherwise specified. All documents cited here incorporated by reference. The following describes preferred embodiments of the present invention, which provides silica for use in vehicles for the care of teeth, such as tooth pastes. Despite the fact that the optimum is the use of silicon dioxide in the care of teeth, the silicon dioxide can be used in various other commodities.

Under the "mixture" means any combination of two or more substances in the form (for example, but without intent to limit) heterogeneous mixture, suspension, solution, Sol, gel, dispersion or emulsion.

"Transparent" means transparent to light, i.e. the image of the object is visible, as if no other blocking material.

Under "means to take care of your teeth" mean means of oral hygiene, such as toothpaste, tooth powder and dental creams (but not only).

"Nezastrakhovannykh silica" means silica, which has a degree of absorption of fats from about 90 ml/100 g and up to 120 ml/100 g

"The new viscosity" means the viscosity increase funds for the care of the teeth, measured using a viscometer Brookfild and expressed in centipoise (SP).

The present invention relates to compositions of amorphous nizkotoksichnogo precipitated silicon dioxide, also known as silicon dioxide, or SiO2which , when incorporated into the toothpaste or the means to care for teeth gives superior cleaning and abrasive characteristics. Since the silica of the present invention is peculiar to a unique combination of low refractive index, a high degree of light transmission, medium abrasiveness and creating a significant viscosity means for care of the teeth, they are particularly useful for making transparent toothpastes with low cost, which are relatively high concentration of water.

To ensure a good cleaning effect, a sufficient amount of abrasive silicon dioxide should be added to the composition of toothpaste so that the rate of radioactive grinding dentin ("RDA") of this paste was between approximately 50 and 200. When an RDA of less than 50 advantages in parts cleaning properties is minimal, whereas RDA>200 creates a serious risk that the toothpaste will be so abrasive that may cause damage to the dentin of the teeth along the gum line. Most manufactured today toothpastes have RDA in the range from 50 to 150 with an average value exactly in the middle - about 100. Preferably the means to care for obami has RDA, at least about 50, such as between 70 and 120, such as between 90 and 110.

RDA toothpaste depends on the hardness (abrasiveness) of the abrasive, and the concentration of abrasive in toothpaste. RDA is determined by the method described in the article "The Measurement of the Abrasion of Human Teeth by a Dentifrice Abrasives: A Test Utilizing Radioactive Teeth", Grabenstetter, R.J.; Broge, R.W., Jackson, F.L. and Radike, A.W., Journal of Dental Research: 37, 1060-68, 1958. The abrasiveness of silica can be measured by the method Einlehner, which is described in more detail below. Correlation between the parameters Einlehner silicon dioxide, silica in toothpaste and RDA values were determined by reliable data and it is reflected in the following equation (I):

RDA=(0,099003×E)+(0,773864×L)+(0,994414×E×L)+(-0,002875 E2)+(-0,094783×L2)+(3,417937),

where E is the loss of brass Einlehner in mg due to a 10% aqueous suspension of silicon dioxide,

L - weight ( wt.%) silicon dioxide is included in toothpaste.

For example, if your toothpaste contains 20 wt.% silicon dioxide having an index of grinding Einlehner (a measure of hardness, described in detail below) about 6.0, then toothpaste will have an RDA of about 100. Toothpaste that has the same value RDA of approximately 100 could be obtained when the concentration of silicon dioxide is about 6.5 wt.% on the basis of a more abrasive silicon dioxide, such as silicon dioxide indicator sanded what I Einlehner, equal to 15. Incorporating the same silicon dioxide indicator grinding Einlehner equal to 15, at a concentration of 20 wt.%, you can obtain tooth paste with RDA about 280.

Unfortunately, abrasive silica, which provide good abrasion and cleaning effect, for example medium-abrasive silica (i.e. having an Einlehner indicators from about 2.0 to 6.0), generally do not possess, respectively, a good transparency and high refractive index and a high degree of light transmission) and do not provide compositions toothpaste good viscosity. For example, sredneagressivnyh silicon dioxide, such as Zeodent®215 silica (manufactured J.M.Huber Corp., Edison, N.J), provides a good abrasive clean and has acceptable low refractive index, and an acceptable degree of light transmission, but it has a low degree of absorption of fats and therefore not so suitable to provide a viscosity in the composition of the toothpaste. The relationship between the type of "structure", the absorption of fat and the effect of the viscosity of silicon dioxide are discussed in more detail in the article "Cosmetic Properties and Structure of Fine-particle Syntetic Precipitated Silecac", S.K.Wason, Journal of Soc. Cosmet. Chem., Vol.29, (1978), p.497-521.

Silicon dioxide Zeodent®215 (also produced J.M.Heber Corp.), on the contrary, provides a good abrasive effect, a high degree of absorption of fats and against the sustained fashion high degree of light transmission, but he has a high refractive index (for example, silicon dioxide Zeodent®215 in table II below).

However, according to this invention the abrasive amorphous silica have been improved so that not only provide excellent abrasive effect, but are also suitable for inclusion in a transparent toothpaste. Adjusting the amount of silicate is initially loaded into the reactor ("excess silicate"), the temperature profile in the reaction autoclaving running in periodic mode, time, temperature, speed, added, the final pH, you can get abrasive on the basis of silicon dioxide having a high degree of absorption of fats (and thus creating good viscosity), and the relatively low refractive index and high light transmission. In his inclusion in the composition of the transparent toothpaste she became sufficiently abrasive to ensure a good cleaning effect at that and had a viscosity that allows the use of toothpaste becomes easy and convenient.

The silica of the present invention are prepared in accordance with the following method. An aqueous solution of alkali metal silicate such as sodium silicate, is loaded into the reactor, such as reactor, preheated to a temperature of from about 65 dookola 100° With equipped with means for stirring, suitable for providing a homogeneous mixture. Preferably the aqueous solution of alkali metal silicate has a concentration of alkali metal silicate approximately 8.0 to 35 wt.%, for example, from about to 8.0 to about 15.0 wt.%. Preferably the alkali metal silicate is a sodium silicate with a ratio of SiO2:Na2Of from about 1 to about 3.5, for example from about 2.4 to about 3.4. The number loaded into the reactor of the alkali metal silicate is from about 10 to about 20 wt.% in the calculation for the entire silicate, used for loading. In the reaction medium, if necessary, may be added to the electrolyte, such as sodium sulphate solution.

In the reactor then simultaneously add: (1) acidifying an aqueous solution tools or acid, such as sulfuric acid, (2) an additional amount of an aqueous solution containing the same type of silicate of alkali metal, and loaded into the reactor, and an aqueous solution preheated to a temperature of from about 65 to about 100°C. an Aqueous solution of acidifying means preferably has a concentration of acidifying means from about 6 to 35 wt.%, for example, from about 9.0 to about 15.0 wt.%. Simultaneous addition of the components is carried out, until you add about 40-60% of the total amount of alkali silicate m is metal, then the temperature was raised to 3°during the remainder of the time allotted for the deposition reaction and autoclaving. The range of temperature increase depends on the reaction temperature deposition. After the entire portion of the alkali metal silicate is loaded, adding acidifying solution lasts as long as the pH in the reactor volume will not drop to values from about 5.0 to about 6.0.

After infusion acidifying means and silicate of an alkali metal terminated, the contents of the reactor are given time to grow old or "digested" for 5-30 minutes with maintaining in the reactor a constant pH. After completion of the reaction ("digestion") the contents of the reactor are filtered and washed with water to remove excess related inorganic salts, until the washing water from the filter cakes silicon dioxide does not reach a conductivity less than approximately 2000 µs. Since the conductivity of the filtrate of silicon dioxide is proportional to the concentration of associated inorganic salts in the filter cake, while maintaining the electrical conductivity of the filtrate is less than 2000 µs, the filter cake can be obtained the desired low concentration of inorganic salts, such as Na2SO4.

The obtained filter cake dioxide silicon rasb ltimeout in water and then dried by any known method of drying, for example by spraying with obtaining a precipitate of silica with a moisture content of from about 3 to about 50%. Precipitated silicon dioxide can then be milled to the desired particle size from about 5 to 25 μm, for example from about 5 to about 15 μm

This abrasive amorphous precipitated silicon dioxide can then be included in preparations for the care of teeth, such as tooth paste.

In addition to the abrasive component, means for care of teeth can also contain other components, such as humectants, thickening agents (known as binders, resins or stabilizing agents), antibacterial agents, fluorides, sweeteners and surfactants.

Humidifiers are used to make the tool for the care of teeth desired consistency or texture, suitable for use in the mouth, and to prevent tools from drying out. Suitable humectants include polyethylene glycol (of different molecular weight), propylene glycol, glycerin, aritra, xylitol, sorbitol, mannitol, lactic and hydrolysates hydrogenated starch, and mixtures thereof.

Thickening agents used in the compositions of funds to care for the teeth of the present invention to provide a gelatinous structure that stabilizes the toothpaste and protects against split the I phase. Suitable tools include thickening thickening agent based on silicon dioxide, starch, glycerides starch, gum karaya (gum of sterculia), gum tragakant, gum, ghatti, Arabian gum, xanthan gum, guar gum, gum VI, carrageenan, sodium alginate, agar-agar, pectin, gelatin, cellulose, cellulose resin, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropylcellulose, hydroxymethylcellulose, hydroxyethylmethylcellulose, methylcellulose, ethylcellulose, sulfated cellulose, and mixtures of these substances. Usually the content of the binder is from about 0 to about 15 wt.% on the composition of the toothpaste.

Antibacterial agents can be included to reduce the presence of microorganisms below the known harmful levels. Suitable antibacterial agents include benzoic acid, sodium benzoate, potassium benzoate, boric acid, a phenolic compound, such as betanaphthol, hartimo, thymol, anethole, eucalyptol, carvacrol, menthol, phenol, amylphenol, hexylphenyl, heptylphenol, op, hexylresorcinol, Laurelville, ministerdesignate, cetylpyridinium, cetylpyridinium, cetylpyridinium. If they are present, the levels of antibacterial agents is preferably from about 0.1 to about Wes.% the composition of the toothpaste.

To impart a pleasant taste to the product can be added sweeteners. Suitable sweeteners include saccharin (sodium, potassium or calcium salt of saccharin, cyclamate (in the form of a sodium, potassium or calcium salt), acesulfam-K, thaumatin, dihydrochalcones of neohesperidine, glycyrrhizin entered ammonium groups, dextrose, levulose, sucrose, mannose and glucose.

Toothpaste should also preferably contain fluoride to help prevent the development and spread of dental caries. Suitable fluoride salts include sodium fluoride, potassium fluoride, calcium fluoride, zinc fluoride, tin fluoride, cinnamony fluoride, monitoroff sodium, monitoroff potassium, laurylamidopropyl, diethylaminoethylmethacrylate, didecyldimethylammoniumchloride, cetylpyridinium, dilaurylracglycerol, carcinological, glycerolipid, getinherited, nationaltrust. Normal levels of fluoride content ranges from about 0.1 to about 5 wt.%.

Condensed phosphates can be used individually or in combination tetrahydrofolate, tetramerista, dinitrodiphenylamine, trinatriumsitraatti, pentatricopeptide and nutribreast.

Surfactants can also be included the AK additional cleaning and foaming agents and they can be selected from anionic surfactants, zwitter-ionic surfactants, nonionic surfactants, amphoteric surfactants and cationic surfactants. Preferred are anionic surfactants such as sulfates of metals, such as sodium lauryl sulfate.

Means for brushing your teeth, described herein, may also include other additional ingredients, such as antisense tool, healing tool, other preventing caries tools, chelating/linking agents, vitamins, amino acids, proteins, other means, prevent the formation of plaque on the teeth or deposits of Tartar, light-tight means, antibiotics, antienzyme, enzymes, controlling the pH of funds, oxidants, antioxidants, bleaches and preservatives.

Finally, the water provides a balance in the composition by adding the above components. Used is preferably deionized water or purified from impurities. Means for care of the teeth should contain from about 10 to about 13 wt.% water.

Hereinafter the invention will be described in more detail using the following specific non-limiting examples.

Examples 1-2

In examples 1-2 silica, intended for use in vehicles for the care of teeth, as well as in other products, have been prepared in accordance with the present invention. Number of Rea is arousih substances and reaction conditions are given in the following table I. First, an aqueous solution containing 13.3 wt.% sodium silicate (having a molar ratio of SiO2:Na2About equal to 2.65), was loaded into the reactor ("excess silicate), heated to 90°C. Then simultaneously added an aqueous solution of sulfuric acid (with a concentration of 11.4 wt.%) and an aqueous solution of sodium silicate (with a concentration of 13.3 wt.%, the molar ratio of sodium silicate to 2.65, the solution is heated to 85° (C) with the speed specified in the following table I. the Addition of silicate was stopped after 48 min, and the addition of acid was continued until the pH in the reactor fell to 7.0. When the pH of the reaction reached to 7.0, the feed rate of the acid was reduced to 10 gallons per minute (GPM)to set the pH of the reaction 5,2-5,5. The temperature in the reactor was maintained at 93°C for 10 min with final establishing and maintaining a pH of 5.2 to 5.5. Content that contains silicon dioxide was filtered and washed with water to receive the filter cakes with conductivity of not more than about 1700 µs. The filter cake then was diluted with water and spray dried to moisture content between 8 and 12%. Dried by spraying the product was milled in a hammer mill to a particle size of 8-15 mm

The number of added reagents and process parameters as follows:

Table I
ExampleExcess silicate (gallon)The feed rate of the silicate, GPMThe feed rate of the acid, GPM
187983,2537,1
275785,9to 38.3

After the above has been obtained product was identified some specific properties of samples of silicon dioxide, including 5% pH % sodium sulfate absorption of fats, level of light transmission ("% transmittance"), refractive index, particle size of silicon dioxide, grinding on Einlehner, brightness, moisture content and % 325 mesh residue. The value of 5% pH was determined in a suspension of 5 g of silicon dioxide in 95 g of water.

The content of sodium sulfate is determined by the conductivity of a suspension of silicon dioxide of known concentration. In particular, weigh a sample of 38 g of moist filter cakes containing silicon dioxide, is placed in a Cup with a capacity of one quart (0,946 l) mixer Hamilton Beach Mixer, Model Number 30, and add 140 ml of deionized water. Stir the mixture for 5-7 min and transfer it into the measuring cylinder 250 ml, fill it to the mark 250 ml of deionized water using the water for rinsing the bowl of a mixer. The sample is stirred several times, preventiva cylinder (closing it). On what I determine the conductivity of the suspension was used for the corresponding device, for example, Cole Palmer CON 500 Model #19950-00. The content of sodium sulfate determined by comparing the conductivity of the sample with a standard curve suspensions, which include the sodium sulfate/silicon dioxide obtained is known by.

Absorption of fat was determined using linseed oil by removing stains. In this experiment, the oil is mixed with silicon dioxide and rubbing with a spatula on a smooth surface until it forms stiff mastigophobia pasta. Measuring the amount of oil that is required to have formed such a pasty mixture, which is when the bleeding curled up in curls, it is possible to calculate the amount of oil absorption of the silica - value, which represents the volume of oil required per unit weight of silicon dioxide for full saturation of the sorption capacity of silicon dioxide. The calculation of the quantities characterizing the absorption of fat can be done as follows:

Prior to determination of the refractive index ("RI") and the degree of light transmission was preparing a series (about 10) of the standard solutions of glycerol/water, so that the refractive index of these solutions was in the range of 1,428-1,46. Need exact ratio of glycerin/water depend on the specific amount of glycerol that was used, which was determined by the laboratory, conducting measurements. Typically, these standard solutions correspond to the range of concentrations from 70 to 90 wt.% glycerin in water. To determine the refractive index of one or two drops of each standard solution separately placed on the stationary plate of the Refractometer (Abbe 60 Refractometer Model 10450). Top plate is fixed and tightly secured. The light source and the Refractometer include and read the indices of refraction for each standard solution.

In each of the flasks at 20 cm3accurately weigh 2.0±0.01 silicon dioxide and add 18,0±0.01 g of each of the respective standard solution of glycerin/water. The flask was subjected to continuous shaking before the formation of dispersions of silicon dioxide tubes from the flasks were removed and placed the flask in a desiccator, which is then connected to the vacuum pump.

The dispersion was subjected to deaerirovannye for 120 min and then visually checked the completeness of DiaryOne. After reaching these samples at room temperature (about 10 minutes) defined % light transmission ("% T") at 590 nm (breakers 20D+) according to the instructions of the manufacturer of the device.

The transmittance in % determined on samples of the dispersions of silicon dioxide/glycerin/water by placing aliquots of each dispersion in a glass tube breakers with successive reading % T of each sample when the wavelength is 590 nm on a scale of 0-100. % light transmission depending on the refractive index RI of the standard solutions used to build the curve shown in the drawing, for example 1 and example 3. The refractive index of silicon dioxide was determined as the position of the constructed maximum (in the form of the ordinate or X-values) on the curve % light transmission from the refractive index (RI). The value on the Y-axis (abscissa) of the maximum peak is a % light transmission of silicon dioxide.

Determination of average particle size was performed using the Leeds and Norfhrup Microtrac II. The laser beam was passed through a transparent cell containing a stream of moving particles suspended in the fluid. The light rays that impinge on the particles scattered at angles that are inversely proportional to their size. Photodetector the group measures the amount of light at different predetermined angles. Electrical signals proportional to the measured values of the light streams are then processed in the microcomputer system by receiving a multi-channel histogram of the distribution of particle sizes.

Size (BE) grinding (Brass Einlehner Abrasion) was measured using Einlehner AT-1000 Abrader. In this experiment, brass wire mesh Fourdrinier weighed and subjected to 10% aqueous suspension of silicon dioxide at a fixed number of the ready and then determined the degree of grinding in milligrams brass, lost this brass wire mesh Fourdrinier per 100,000 revolutions. Supplies needed for this experience (mesh brass wire, wear plates, PVC pipe), issued Duncan Associates, Rutland, Vermont and sold as "Einlehner Test Kit". In particular, brass mesh (Phospos Bronze P.M.) were prepared by washing in hot soapy solution (0.5% Alconox) in the tank when exposed to ultrasound for 5 minutes followed by washing in tap water and again in a beaker filled with 150 ml of water, placed in a container with exposure to ultrasound. Grids were washed in tap water, dried in an oven at 105°C for 20 minutes, cooled in a desiccator and weighed. To manipulate meshes used tweezers to prevent grease contamination meshes with the skin. Cylinder for experience Einlehner collected with the plate, intended for wear, and weighted grid (outlined by the red line, bottom - parasitaemia side) and fixed. Plate, intended for wear, was used about 25 experiments until worn out; weighted net was used only once.

A suspension of silicon dioxide 10%, obtained by mixing 100 g of silicon dioxide with 900 g of deionized water was poured into the cylinder for testing Einlehner. Einlehner PVC pipe was connected inen to a mixing rod. PVC pipe has 5 numbered positions. For each test used each item in ascending order, then he was thrown out. Installation for abrasion on Einlehner again collected and the device was installed at 87000 speed for the run. Each experiment took about 49 minutes. After the loop has completed, the grid was removed, rinsed in tap water, placed in a glass of water and was set in an ultrasonic bath for 2 min, washed with deionized water and dried in an oven at 105°C for 20 minutes, Dried grid was cooled in a desiccator and again weighed. For each sample spent 2 experience, the results were averaged and expressed in mg loss per 100,000 revolutions. The result, measured in mg loss per 100,000 revolutions, for a 10% suspension was equal to 10% grinding brass Einlehner (BE).

To measure the brightness values of the materials in the form of a finely ground surface of the powder is pressed into a ball with a smooth surface and then carried out the determination using a Technidyne Brightmeter S-5/BC. This device has a two-beam optical system in which the sample is irradiated at an angle of 45° and evaluate the reflected light at 0°. This corresponds to TAPPI methods of determination Kzt452 and T, as well as ASTM Standard D985. Powdered material is pressed into the ball with a thickness of about 1 cm at a pressure sufficient to keep the surface of the ball would is as smooth and even without rychlosti and no gloss.

To determine the moisture content of the silica, the sample of silicon dioxide is dried for 2 hours at 105°and determine the moisture on the difference, expressed in percent.

Also can be measured % 325 sieve residue, which determines the number of granular particles in toothpaste. Because, among other things, the presence of granular particles creates an unpleasant sensation in the mouth and because these granular particles interfere with the dissolution of the paste in the mouth, it is preferable that the content of % 325 residue on the sieve was as little as possible.

To determine % 325 residue on the sieve is weighed 50 g of silicon dioxide in the glass 1 liter with 500-600 ml of water. Allow the silica to settle in the water, then the mixture is stirred until all the sludge will not be distributed. Bring the water pressure in the spray nozzle (Fulljet 9,5, 3/8 G, 316 stainless steel, steel. Spraying Systems Co.) up to 20-25 pounds per square inch (PSC). While holding the material mesh sieve (mesh 325 mesh, 8" diameter) 4 to 6 inches below the nozzle and spraying gradually pour the contents of the glass on the sieve mesh 325 mesh. Rinse deposited on the walls of the glass residue and poured on the filter. Washed for 2 minutes, moving the nozzle from side to side in quick movements. After sputtering for 2 min (all particles smaller than the size of the grid cell must pass through the mesh) wash the residue retained on the filter, od is at the party and then take them into pre-weighed aluminum Cup for weighing, washing a thin trickle of water from the bottle. You need to use the minimum amount of water to be sure that the rest moved into the Cup for weighing. The Cup is allowed to stand for 2-3 minutes and then decanted distilled pure water. The Cup is placed in an oven ("Easy-Bake" with infrared radiation or oven heated to 105°C) and dry the residue to constant weight. Re-weigh the dry residue of the sample and the Cup.

Calculate % 325 residue as follows:

Obtained in accordance with examples 1-2 products of silica examined the above ways. The obtained results of the research of the characteristics listed in the following table II. For comparison, table II also contains the characteristics of the three known from the prior art of silica, supplied J.M.Huber Corporation, Edison, New Jersey).

Table II
Example 1Example 2Zeodent® 113Zeodent® 215Zeodent® 115
5% pH7,17,27,37,07,1
% Na2SO41,611,920,350,551,14
Will the distribution of fat, ml/100 g116103868893
% light transmission84,886,46180,186,8
Refractive index1,4451,4411,4381,4411,451
The average particle size, microns11,411,89,810,510,7
Grinding on Einlehner mg/100000 rpmto 2.063,03the 5.656,234,11
Brightness98,698,598,698,598,4
% humidity9,98,07,29,88,3
% 325 residue1,590,300,500,500,28

As can be seen from table II, the silica obtained in examples 1-2, meet all the requirements necessary for the production of transparent toothpaste (namely, each had a low refractive index and high light transmission), at the same time being sufficiently hard or abrasive for the production of toothpaste with acceptable or good cleaning cloth is th ability. As you can see, three are known from the prior art silicon dioxide have good optical properties for inclusion in a transparent toothpaste with some water content, but in General have the worst indicators absorption of fat, which means that they will create a poor viscosity.

To demonstrate the efficiency in food consumption, abrasive silica obtained according to examples 1-2, were included in the form of powders in six different formulations of toothpastes (numbers 4, 5, 9, 10, 13 and 14), which are set forth in tables III, IV and V. the Compositions of table III contains 10% water, the composition of table IV contains 12% water, and the composition of table V contain 13% water. The effectiveness of these compositions were compared with the efficacy of the compositions of toothpastes containing known from the prior art abrasive silica Zeodent® 113, Zeodent® 215 and Zeodent® 115 from J.M.Huber Corporation. These compositions toothpastes below in tables III, IV and V. the Composition of toothpastes 1, 6 and 11 contain abrasive silicon dioxide Zeodent® 113; formulations of toothpastes 2, 7 and 12 contain abrasive silicon dioxide Zeodent® 215; and the composition of toothpastes 3 and 8 contain abrasive silicon dioxide Zeodent® 115.

These formulations of toothpastes were prepared in the following way. The first mixture was prepared by mixing the following ingredients: glycerin, sorbitol, polyethylene glycol (CARBO WAX from 600 Uion Carbide Corporation, Danbury, CT), carboxymethylcellulose (CMC-7MXF from Aqualon division of Hercules Corporation, Wilmington, DE), and stirred the mixture until complete dissolution of the components. A second mixture was prepared by combining the following ingredients: deionized water, sodium saccharinate, tetranitro pyrophosphate, sodium fluoride, and then stirring the mixture until complete dissolution of the components. The first and second mixture were combined with stirring. Then to the combined mixture was added the dye and mixed with the receipt of "premix".

The premix was loaded into a Ross mixer (model 130 LDM, Charles Ross & Co., Haupeauge, NY), added thickening silica and abrasive silicon dioxide and the premix was mixed without vacuum. Then provided a vacuum of 30 inches (2,5×30=75 cm) and each sample was stirred for 15 min, then added sodium lauryl sulfate and flavor. The resulting mixture was stirred 5 minutes at low speed stirring.

Were prepared with 14 different compositions toothpastes according to the following formulations shown in tables III-V, where the number is listed in grams:

Table III
IngredientsTrack number
12345
The glycerine 99,5%25,00025,00025,00025,000
Sorbitol 70,0%35,10735,10735,10735,10735,107
Deionized water10,00010,00010,00010,00010,000
Carbowax 6003,0003,0003,0003,0003,000
CMC-7MXF0,4000,4000,4000,4000,400
Tetrahydrofolate0,5000,5000,5000,5000,500
The sodium saccharinate0,2000,2000,2000,2000,200
Sodium fluoride0,2430,2430,2430,2430,243
Thickening SiO2Zeodent® 1655,5005,5005,5005,5005,500
The abrasive. SiO2Zeodent® 11318,0000,000,000,000,00
The abrasive. SiO2Zeodent® 2150,0018,0000,000,00000
The abrasive. SiO2Zeodent® 1150,000,0018,0000,000,00
The abrasive. SiO2for example 10,000,000,0018,0000,00
The abrasive. SiO2for example 20,000,000,000,0018,000
FD&CBlue #1, 1,00% p-p0,2000,2000,2000,2000,200
Sodium lauryl sulfate1,2001,2001,2001,2001,200
Flavor0,6500,6500,6500,6500,650

td align="center"> 0,00
Table IV
IngredientsTrack number
678910
The glycerine 99,5%25,00025,00025,00025,00025,000
Sorbitol 70,0%33,10733,10733,10733,10733,107
Deionized water 12,00012,00012,00012,00012,000
Carbowax 6003,0003,0003,0003,0003,000
CMC-7MXF0,4000,4000,4000,4000,400
Tetrahydrofolate0,5000,5000,5000,5000,500
Sodium saccharinate0,2000,2000,2000,2000,200
Sodium fluoride0,2430,2430,2430,2430,243
Thickening silica Zeodent® 1655,5005,5005,5005,5005,500
Abrasive silicon dioxide Zeodent® 11318,0000,000,000,000,00
Abrasive silicon dioxide Zeodent® 2150,0018,0000,000,000,00
Abrasive silicon dioxide Zeodent® 1150,000,0018,0000,000,00
Abrasive silica according to example 10,000,0018,0000,00
Abrasive silica according to example 20,000,000,000,0018,000
FD&Cblue #1, 1,00% p-p0,2000,2000,2000,2000,200
Sodium lauryl sulfate1,2001,2001,2001,2001,200
Flavor0,6500,6500,6500,6500,650

Table V
IngredientsTrack number
11121314
The glycerine 99,5%25,00025,00025,00025,000
Sorbitol 70,0%32,10732,10732,10732,107
Deionized water13,00013,00013,00013,000
Carbowax 6003,0003,0003,0003,000
CMC-7MXF0,4000,4000,4000,400
Tetrahydrofolate0,5000,5000,5000,500
The sodium saccharinate0,2000,2000,2000,200
Sodium fluoride0,2430,2430,2430,243
Thickening silica Zeodent® 1655,5005,5005,5005,500
Abrasive silicon dioxide Zeodent®11318,0000,000,000,00
Abrasive silicon dioxide0,0018,000,000,00
Zeodent®215
Abrasive silica according to example 10,000,0018,000,00
Abrasive silica according to example 20,000,000,0018,00
FD&Blue #1, 1,00% p-p0,2000,2000,2000,200
Sodium lauryl sulfate1,2001,2001,2001,200
Flavor0,650 0,6500,6500,650

After you have prepared the above composition 1-14, defined properties associated with transparency gel toothpaste, such as refractive index, transparency and turbidity, as described below.

The refractive index of toothpaste was determined by selecting a drop of toothpaste and placing it in Abbe 60 Refractometer Model 10450 and immediately read the refractive index.

The definition of transparency is a subjective method, in which a strip of toothpaste squeezed on a page of white paper with text typeface. A score of 10 is assigned if the text is easy to read, a score of 1 when the text is not visible and mid-term evaluation from 2 to 9 as improve the clarity of the text. A rating of 8 or more is considered adequate for gel paste with good transparency, supporting transparency abrasive silicon dioxide. Typically, the level of transparency of toothpaste 10 will correspond to the measure of turbidity (described below) of less than 40; the level of transparency 9 - measure the turbidity of about 45-55; transparency 8 - measure turbidity of about 55-65 and transparency 7 - measure the turbidity of about 65-70.

Measure turbidity transparent gel toothpaste is determined by the transmittance using a colorimeter Gadner XL-835. The instrument is first calibrated according to the manufacturer's instructions. Then two glass slides for microscopy sizes 38×75 mm and a thickness of 0.96 was 1.06 mm, placed on a flat surface. One glass is covered with a spacer made of plexiglass (38×75 mm, 3 mm thick and 24×47 mm open area). Gel toothpaste squeezed in an open area Plexiglas spacer. The second glass is placed over a tooth paste and pressed by hand to remove excess toothpaste and air. The sample is placed in a zone of passage of the light beam pre-calibrated instrument and record the turbidity recorded at three different positions of the sample and average. Lower turbidity correspond to a more transparent, translucent toothpaste.

The Brookfield viscometer (Model RVT) with a Helipath stand and spindle T-E is used to determine the viscosity of the toothpaste. The speed of the viscometer is set to 5 rpm container with a sample of toothpaste placed in a bath of water at 25°to balance. The viscosity is measured on three levels and average. The results are given in centipoise (SDR).

The results of measurement of refractive index, transparency, turbidity are given in table VI along with the concentration of water in the toothpaste and the refractive index of the abrasive dioc the IDA silicon.

Table VI
No. HDMI.Abrasive silicon dioxideRI silicon dioxideRI

premix
Weight. % H2OViscosity (centipoise)TransparencyTurbidity
1.Zeodent®1131,4381,44610420000673
2.Zeodent®2151,4411,44610360000768,5
3.Zeodent®1151,4511,44610530000768
4.Example 11,4451,44610570000945
5.Example 21,4411,44610450000953
6.Zeodent®1131,4381,442124000001029
7.Zeodent®2151,4411,44212 3700001038
8.Zeodent®1151,4511,44212440000670,4
9.Example 11,4451,442124600001028,5
10.Example 21,4411,442124800001027,2
11.Zeodent®1131,4381,44113480000951
12.Zeodent®2151,4411,441133800001035
13.Example 11,4451,441135000001023
14.Example 21,4411,441134900001029

Composition of toothpaste 1 through 5 contain 10% water, and the premix toothpaste has a refractive index 1,446. From the data presented in table VI, it is seen that the farther the refractive index of silicon dioxide from the refractive index Prem is KSA toothpaste, the worse optical properties of toothpaste (transparency and turbidity). Control compositions 1-3, containing abrasives based on the silica of the prior art, have a refractive index that is different 0.005-0,008 units from the refractive index of the premix, while compositions containing abrasive silica according to the invention (compositions 4-5)have refractive indices, only 0,001-0,004 unit different from the refractive index of the premix. In addition, the silica according to the invention provide excellent viscosity of toothpaste. Only silica obtained according to the invention, have good optical properties and provide good viscosity.

Composition of toothpaste from 6 to 10 contain 12% of water, and the premix toothpaste has a refractive index 1,442. From the data presented in table VI, we see that the toothpaste composition 8 containing known from the prior art abrasive silicon dioxide Zeodent 115, has a refractive index that is different on 0,009 units from the refractive index of the premix toothpaste, resulting in poor transparency and turbidity toothpaste. Compositions 6 and 7 (containing known from the prior art abrasive silica) and compositions 9 and 10 (containing abrasive silica of the present invention in which the reamers 1-2) have good optical properties, since the refractive indices of the abrasive silica closely correspond to the same indicators of the premix. However, abrasive silica according to the invention provide a higher viscosity than known abrasive silica. Only abrasive silica of the present invention possess good optical properties and good characteristics of the generated viscosity.

Composition of toothpaste from 11 to 14 contain 13% of water, and the premix toothpaste has a refractive index 1,441. All these compositions have good optical properties, since the refractive indices of these abrasive silica closely correspond to the same indicators of the premix. Abrasive silica of the present invention do provide a lower turbidity than the well-known abrasive silica, especially in comparison with the composition 11. In addition, abrasive silica of the present invention provide a higher viscosity than known abrasive silica. Only abrasive silica of the present invention possess good optical properties and characteristics of the generated viscosity.

The person skilled in the art will understand that changes are possible in relation to the described embodiments of the invention without departing from the broad concept izopet the deposits. It is thus clear that the invention is not limited to the specific described embodiments, and it is implied that the invention covers all modifications falling under the scope of the present invention and the related idea of the invention as defined by the attached claims.

1. Transparent means for care of teeth, comprising from about 10 to 13 wt.% water, abrasive nezastrakhovannykh precipitated silicon dioxide having a refractive index from about 1,439 up to 1,450, absorption of fats from about 90 ml/100 g to about 120 ml/100 g, the transmittance of more than about 60% and polishing Brass Einlehner less than about 5 mg loss/100,000 revolutions; and means for care of teeth has a turbidity less than about 50, the RDA from about 50 to 200 and a refractive index from about 1,439 up to 1,450; viscosity of more than about 425000 SDR.

2. The tool according to claim 1, having a measure of the turbidity of less than about 35.

3. Transparent means for care of teeth, including

a) a premix consisting mainly of thickening means, other than silicon dioxide, deionized water and the humectant selected from the group consisting of glycerol, sorbitol and polyethylene glycol; and the premix has a refractive index from about 1,439 up to 1,450 and (b) from about 0.01 to about 35 wt.% abrasive nizkotoksichnogo najdennogo silicon dioxide, having a refractive index from about 1,439 up to 1,450, absorption of fats from about 90 ml/100 g to about 120 ml/100 g, the transmittance of more than about 60%, the rate of polishing Brass Einlehner less than about 5 mg loss/100,000 revolutions, and c) from about 10 to about 13 wt.% water, and the solution has an RDA of more than about 50, a measure of the turbidity of less than about 50 and a viscosity of more than about 425000 SDR.

4. The method of obtaining funds for the care of teeth, including stage

a) preparation of a premix by mixing a thickening agent means other than silicon dioxide, deionized water and the humectant selected from the group consisting of glycerol, sorbitol and polyethylene glycol; and the premix does not contain silicon dioxide and has a refractive index from about 1,439 up to 1,450, and b) mixing the premix with abrasive nezastrakhovannykh deposited silicon dioxide having a refractive index from about 1,439 up to 1,450, absorption of fats from about 90 ml/100 g to about 120 ml/100 g,

the transmittance of more than about 60%, the rate of polishing Brass Einlehner less than about 5 mg loss/100,000 revolutions, obtaining a transparent means to care for teeth with RDA more than about 50, a measure of the turbidity of less than about 50 and a refractive index from about 1,439 up to 1,450.

5. The method according to claim 4, in which the means for care of teeth has a viscosity more than the Colo 425000 SDR.

6. The tool according to claim 3, having a refractive index less 1,448.

7. The tool according to claim 3, characterized in that it has a turbidity less than about 35.



 

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14 cl, 7 ex

FIELD: medicine.

SUBSTANCE: it is necessary to prepare a patient to therapy due to local treatment of skin and available mucosa of organs subjected to chemo- and/or radiation impact, with butyric extracts of medicinal plants; and introduction of immunomodulating preparation (IMP) and an adsorbent in the course and after the course of radiation and/or chemotherapy. Additionally, one should perorally introduce protective species comprised out of compatible pharmacopoeic medicinal plants matched with possibility for their combined protector action upon tumor-unaffected tissues of sick organ and upon the tissue of all healthy organs being in area of chemo- and/or radiation impact. As IMP and adsorbent mentioned one should apply, correspondingly, a plant adaptogen and a plant adsorbent. Introduction of species, adaptogen and adsorbent should be started while preparing a patient to chemo- and/or radiation therapy to introduce them daily in the course of therapy conducted. Local treatment of skin and mucosa should be fulfilled after each seance of radiation and/or chemotherapy. Species, plant adaptogen and plant adsorbent should be introduced at certain intervals between each other. The innovation enables to decrease traumatism of chemo- and/or radiation therapy.

EFFECT: higher efficiency of prophylaxis and therapy.

14 cl, 7 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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