Method of correction of human functional condition
FIELD: medicine; physiology and therapy.
SUBSTANCE: patient's cardiointervalograms are registered and analysed in real time mode. Respiratory movements are synchronised with own heart rate. Command information to man on inspiration-expiration is generated by microcontroller on basis of analysis of ongoing cardiointervalogram, and inspiration command is generated by microcontroller upon registration of cardiointervalogram's maximum and provided the time interval of analysis lockout is completed, when microcontroller's commands are pending even at extremum. Expiration command is generated upon registration of cardiointervalogram's minimum and the time interval of analysis lockout starts at expiration command with duration of three cardio cycles, or at inspiration command with duration of one cardio cycle.
EFFECT: method increases efficacy of systems of diagnostics and correction of human functional condition.
The invention relates to medicine, namely to the physiology and therapy, and can be used in systems of diagnostics and correction of human functional state.
Known "Method of functional physiological correction of the human condition and diagnosis in the process of correction" (patent RF №2221477), the essence of which is the visual representation of the patient's own cardiotocogram (kardiointervalogrammy) in real time while the patient examines cardiotocogram and synchronizes its respiratory movements with variations of their own heart rhythm: the higher the heart rate provides a breath, but at a lower heart rate exhale. This cardiorespiratory synchronization (training with biofeedback (BFB) cardiorespiratory system, cardiorespiratory biofeedback training) stimulates the vagus nerve, leading to relaxation of the patient. The disadvantage of this method is actively involved in the analysis of cardiotocograms patient, which reduces the degree of relaxation. The second disadvantage is the attachment of the patient (subject) to the monitor, which imposes limitations on the conditions of carrying out of sessions of biofeedback and complicates or even makes it impossible combination of sessions biological reverse the th connection with other types of active load on the body (physical, psychological and other).
The objective of the invention is to increase the efficiency effects on the autonomic nervous system ways cardiorespiratory synchronization with the organization of biological feedback by eliminating additional psychological burden on the patient in the form of analysis of their kardiointervalogrammy, as well as increasing the mobility of the entire complex cardiorespiratory synchronization for a combination of biofeedback sessions with other types of active load on the body by eliminating the mandatory visual communication of a patient with a complex.
The invention consists in the correction of human functional state by entering into a chain biofeedback microcomputer Registrar analyzer, which analyzes kardiointervalogrammy and in optimal time generates control commands to the breath, which obeys the patient.
Figure 1 shows the block diagram of complex cardiorespiratory synchronization; figure 2 presents kardiointervalogrammy belated response heart rate sauraseni (HR) inhalation (with "paradoxical" reaction); figure 3 shows the block diagram of the algorithm subroutine that provides the analysis of kardiointervalogrammy and the formation of governors with whom galow; figure 4 presents a comparison of actual schedules kardiointervalogrammy during the session cardiorespiratory biofeedback training of the proposed method and the method proposed in the prototype, one and the same person; figure 5 shows kardiointervalogrammy during the session cardiorespiratory biofeedback training of the proposed method in combination with a uniform load on the bike. Figure 6 presents kardiointervalogrammy when combined sessions cardiorespiratory biofeedback training with orthostatic breakdown.
The method is as follows. Person 1 impose the electrodes 2 microcomputer Registrar analyzer. Potentials electrocardiogram amplified biopotential amplifier 3, is filtered from the noise filter unit 4 and are fed to the analog input of the microcontroller 5, which allows you to digitize the signal, select RR-intervals, and then to register them in memory (block 7, figure 1), to analyze and, as a result of analysis, to generate control signals on the breath, which is coming to the unit issuing commands (section 6, figure 1). The power output of commands affects the hearing and / or vision, and / or tactile person, i.e. issues commands in the audio and / or visual and / or tactile form. Man obeys the commands and makes breathing magic cube MOV is I, which is inversely affect the RR-intervals (heart rate), i.e. the chain biofeedback is closed. To achieve maximum relaxation recommended posture lying and(or) with his eyes closed.
As you know, when you inhale RR-intervals are shortened relative to the original level (heart rate increases), and when you exhale RR-intervals are extended relative to the original level (heart rate decreases). The process monotonic decrease of RR-intervals on the breath for most healthy people, lasts about 4-7 seconds, and then, even with continued inhalation, RR-intervals start to increase. The process monotonic increase of RR-intervals on the exhale for most healthy people, lasts about 3-5 seconds (and is usually a faster process monotonic decrease of RR-intervals), and then, even with continued exhalation, RR-intervals begin to decrease. If at the moment of crossing the maximum kardiointervalogrammy change the phase of respiration, then comes the cardiorespiratory synchronization (the phenomenon of functional resonance cardiorespiratory system ) with maximum stimulation of the vagus nerve and relaxation of the patient. This phenomenon relies on the selected prototype, as well as a number of other similar techniques [2, 3]. However, the bi organization is logical feedback in these ways involves active involvement in the analysis of cardiotocograms patient, that reduces the degree of relaxation, and also forms the attachment of the patient (subject) to the monitor, and this imposes limitations on the conditions of carrying out of sessions of biofeedback. To address these shortcomings may input circuit biofeedback microcomputer Registrar analyzer, which analyzes kardiointervalogrammy and in optimal time generates control commands to the breath, which obeys the patient.
Practical tests how to use biofeedback evaluation kardiointervalogrammy patient microcomputer Registrar analyzer in real time showed that in some cases the nature of changes in RR-intervals during inhalation and exhalation is not subject to the above stated rule and the opposite occurs (the"paradoxical") reaction, in particular some people had a delayed reaction accelerations (ischemia) to the heart rhythm in the breath (exhale)that resulted after one extremum other extremes, not directly associated with the phenomenon of cardiorespiratory synchronization (functional response), and dependent on the individual characteristics of the response of heart rate on respiratory movements. Because of this microcomputer Registrar analyzer was incorrectly team. For the liquid is tion of this negative effect was introduced immediately issued for command block interval analysis, during which the presence of an extremum does not lead to the issuance of a management team. The duration of the interval, it is advisable to take approximately three cardiocycle after inhalation and one cardiac cycle after the command exhalation. This value is a compromise between the errors of the first and second kind, that is, between the pass extremum, due to the resonant properties of the cardiorespiratory system and false positives extremes. The difference in the duration of these two interlocking due to the different speeds of the processes of increase and decrease of RR-intervals (figure 2).
The block diagram of algorithm subroutines microcontroller, providing analysis of kardiointervalogrammy and the formation of control signals with respect to the interval presented in figure 3.
Figure 4 presents a comparison of cardiointervalogram received from the same person in the same conditions as described in the prototype (on the left in figure 4) and the proposed method (right in figure 4). According to subjective feelings, the depth of relaxation in the organization biofeedback proposed method is higher than with the organization of biological feedback method of the prototype. On objective data when cardiorespiratory synchronization method of the prototype averaged RR-intervals of ugliness of 0.75 to 0.87 (HR, respectively, decreased from 80 to 69 beats./min), and when cardiorespiratory synchronization method proposed average RR-interval was lengthened from from 0.76 to 1.05 with (HR, respectively, decreased from 79 to 57 beats./min), reflecting the greater relaxation of the patient and greater stimulation of the vagus nerve of the proposed method in comparison with the prototype. Similar results were obtained in other subjects.
The man in the proposed method, the organization of biological feedback plays a passive role, i.e. people just obey the commands microcomputer Registrar analyzer, and visual communication with technical devices is not required, sufficient audio connection. This allows to combine the sessions of biofeedback with other types of active load on the body (physical, psychological). Figure 5 presents an example of kardiointervalogrammy when combined sessions cardiorespiratory biofeedback training of the proposed method with a uniform load on the bike, and figure 6 presents kardiointervalogrammy when combined sessions cardiorespiratory biofeedback training with orthostatic breakdown.
Thus, the input into the circuit biofeedback microcomputer Registrar analyzer, which analyzes kardiointervalogrammy and in optimal time generates control commands to the breath-idoh, which obeys the patient, eliminates additional psychological burden on the patient in the form of analysis of their kardiointervalogrammy, and also eliminates the mandatory visual relationship of the patient with a technical device that allows you to achieve greater relaxation of the patient, to improve the efficiency effects on the autonomic nervous system ways cardiorespiratory synchronization with the organization of biological feedback, and also to increase the mobility of the entire complex cardiorespiratory synchronization for a combination of biofeedback sessions with other types of active load on the body. Enter in the routine analysis of extrema of interlocking analysis allows to take into account the individual reaction accelerations (ischemia) to the heart rhythm in the breath (exhale) with the advent followed by one extremum of kardiointervalogrammy other extremes, not directly associated with the phenomenon of cardiorespiratory synchronization (functional response) and which is in this case the noise.
Sources of information
1. Wasilla Mrs x, Zingerman A., Konstantinov M.A. Study the resonance characteristics of the cardiovascular system. //Human physiology, 1983. V.9, No. 2. S.257-265.
2. RF patent №2190952. Method for the treatment of opium addiction, burdened neurocytol the Torno dystonia, adolescents in the acute period / Yakovlev NM, Smetankin A.A. Publ. 2002.10.20.
3. Auth. St. USSR №1745200. The method of functional correction of blood pressure/ Gandarewa L.N., Vasilevsky N.N., Seisenbekov TERMS and others, Publ. 1992.07.07.
The method of functional correction of the human condition, including the registration and analysis of kardiointervalogrammy patient in real-time and synchronization of breathing with oscillations own heart rhythm: the breath is when you register the maximum kardiointervalogrammy, and the exhalation is performed when registering the minimum kardiointervalogrammy, characterized in that commands breath-person forms a microcontroller based on the analysis of the current kardiointervalogrammy, and the breath is issued by the microcontroller when registering maximum kardiointervalogrammy and provided the time interval of analysis, during which the microcontroller does not issue commands even in the presence of an extremum, and the exhalation is issued at check minimum kardiointervalogrammy and provided the time interval of analysis, with the time interval of analysis begins during the team's inspiration with a duration of three cardiac cycle or exhalation with a duration of one cardiocycle.
FIELD: medicine, neuroophthalmology.
SUBSTANCE: it is necessary to register electroencephalogram (EEG) and at disorganized low-amplitude EEG, when amplitude of alpha-rhythm is below 30 mcV or is not detected at all it is necessary to prescribe nystenon per os per 1 tablet twice/d daily for 2 wk. In case of high-amplitude hypersynchronous EEG at amplitude of alpha-rhythm being 100 mcV and more one should prescribe glycin per 1 tablet 100 mg sublingually twice/d daily for 2 wk. Then comes video-training with the help of "Amblyocor-01" device for 2 wk along with simultaneous intake of earlier prescribed preparations. In case of disorganized low-amplitude EEG one should fulfill training in the mode of "relaxation", in case of high-amplitude hypersynchronous EEG - in the mode of "activation". The innovation enables to affect central departments of optic analyzer.
EFFECT: higher efficiency of correction.
FIELD: medical engineering.
SUBSTANCE: device has means for acting upon object under study, means for recording responses having transducers connected to computer via signal input/output unit, photorecorder unit having programmed control mechanism and frame marker unit having in series connected control desk, frame marker, superposed responses photorecorder, programming unit and switchboard connected to control desk, means for acting upon object, means for recording responses and computer. Photorecorder programming unit has cam mechanism, the switchboard has relay circuits, the frame marker unit has means for recording treatment protocol and means for recording current events being tape drive with transparent tape coupled with tape drive with exposed film. The means for recording responses have magnetic tape recorder connected to control desk and transducers via switchboard. Tape recorder signal input is connected to microphone for recording vocal data describing current experiment condition and testee data.
EFFECT: enhanced effectiveness in recording biopotentials and creating feedback links among testees; wide range of functional applications.
2 cl, 6 dwg
SUBSTANCE: method involves carrying out clinical and diagnostic examination and additionally measuring latent period of III peak on invoked potential curve from acoustic invoked stem potentials. Cerebral stem injuries are determined from neuromuscular electrodiagnostic data. Latent period III peak value being above or below a norm and injured medial cerebral stem region allover the stem thickness or totally injured lateral and caudal stem regions or all said regions injury taking place, high intraoperation trigeminocardial reflex risk degree is diagnosed in patients suffering from vestibular neuroschwannoma. Latent period III peak value being above or below a norm and no injuries of cerebral stem or latent period III peak value corresponding to norm and totally injured lateral and caudal stem regions at the same time or only medial cerebral stem regions taking place, moderate risk degree is diagnosed. Normal latent period III peak value and no injuries of cerebral stem being the case, low risk degree is to be diagnosed.
EFFECT: high accuracy of diagnosis.
SUBSTANCE: method involves recording and analyzing rhythm cardiogram (RCG) data. RCG segments are recorded in rest state and under functional tests - active orthostatic AOT, Valsalva test (VT), Ashner test (AT), controlled physical exercise test(PWC120). RCG fragments are recorded that are characterized by segments having no wave change(s) under functional tests of various intensity. Tests are determined in which stabilization segments occur and their duration is recorded. If stabilization segments are recorded under PWC120 loading only, additional test with Nitroglycerol taken is carried out. If they vanish in the Nitroglycerol test, initial angina pectoris is diagnosed that corresponds to the first class according to Canadian classification. If stabilization segments are recorded under PWC120 and AOT and they do not vanish in the Nitroglycerol test, moderate angina pectoris is diagnosed that corresponds to the second class according to Canadian classification. If stabilization segments are recorded under PWC120, AOT, VT and AT and they do not vanish in the Nitroglycerol test, severe angina pectoris is diagnosed that corresponds to the third or fourth class according to abovementioned classification. Ischemia episode duration is determined from the number of intervals recorded on stabilization segment from expression RRxn, where RR is the interval length in s, n is the number of these intervals on stabilization segment. Changes of stabilization segments duration on RCG are interpreted in terms of abnormal process duration. The more often stabilization segments occur and their duration grows, the more often and longer angina pectoris episodes. Treatment results are also evaluated. The treatment being effective, stabilization segments occur more seldom, become shorter or vanish completely.
EFFECT: high accuracy of diagnosis.
2 cl, 6 dwg
SUBSTANCE: method involves determining spectral power boundaries of cardiac rhythm TR, cardiac rhythm variability distribution power CRV in frequency ranges of UVLF 0-0.025 Hz, VLF 0.026-0.075 Hz, Lf 0.076-0.15 Hz, HF 0.16-0.5 Hz before and after 2 weeks from the moment of prescribing anti-hypertensive preparations. Their spectral power is calculated as scores. One score corresponds to one unit of Hz value. Percent power distribution is calculated within cardiac rhythm spectrum. If growth or drop of total TR spectrum density from scores 27-135, CRV in frequency ranges of HE scores from 8-67, LF scores from 7-54, VLF scores from 4-21, UVLF scores from 1-5 take place after 2 weeks of hypotensive therapy, and percent power distribution of spectral density of oscillations within the cardiac rhythm spectrum has disorders: HF from 30-54%, LF from 26-40%, VLF from 10-23%, UVLF from 2-7%, the hypotensive therapy is considered to be ineffective.
EFFECT: wider range of means for estimating treatment effectiveness.
FIELD: medicine, cardiology.
SUBSTANCE: it is necessary to register and measure temporary values of cardiac cycle structure in the state of rest including the duration of cardiac cycle and diastole. Moreover, one should additionally register and measure the duration of isometric relaxation phase and quick filling phase, then one should detect intradiastolic value at the duration of cardiac cycle ranged 0.66-1.013 sec by the following formula: where IDV - intradiastolic value (%); Ir - the duration of isometric relaxation phase (sec); Qf - the duration of quick filling phase (sec); Do - the duration of diastole (sec). When IDV corresponds to 26.6-36.6% one should state upon functional cardiac state to be normal response. The innovation enables to diagnose initial stages of the decrease of functional cardiac state, simplify the procedure of evaluating human functional heart.
EFFECT: higher accuracy of evaluation.
1 dwg, 4 ex, 2 tbl
SUBSTANCE: method involves carrying out cardiac rhythm spectral analysis. Cardiac rhythm parameters variability plots are shown to patient, representing parasympathetic and sympathetic cardiac rhythm regulation. Patient combines calm deep breathing with smooth expiration with not rarer than 9-10 breathing movements per 1 min during 5 min with muscle relaxation and positively tinged images. The patient chooses his/her state with the view on spectrum plot, so that cardiac rhythm spectral analysis parameters representing parasympathetic regulation be equal to or greater than and cardiac rhythm spectral analysis parameters representing sympathetic regulation. Next, the patient makes 20 curtsies within 30 s, and biofeedback session is continued during 5 min.
EFFECT: enhanced effectiveness of treatment.
FIELD: medicine, quick-test diagnostics.
SUBSTANCE: one should register the range of the dynamic row of cardiointervals, measure the power in the ranges of this row and total power of the range (TP), detect normative values of total spectral power and power in the ranges of the row neutralized by great population of people under standard conditions of the record. Moreover, power should be measured within the following ranges: 0.003-0.004 Hz, 0.0062-0.0072 Hz, 0.010-0.014 Hz, 0.0163-0.0173 Hz, 0.023-0.029 Hz, 0.031-0.035 Hz, 0.039-0.041 Hz, 0.044-0.048 Hz, 0.25-0.35 Hz, calculate the value S by the following formula: Si=Ni*100%/NTP and at deviation of Si value within 0.003-0.004 Hz being above normative value one should diagnose pathological state of suprasegmental level of ANS; at deviation of Si value within 0.0062-0.0072 Hz being above normative value one should diagnose pathological state of hypothalamus; at deviation of Si value within 0.010-0.014 Hz being above normative value one should diagnose pathological state of hypophysis; at deviation of Si value within 0.0163-0.0173 Hz being above normative value one should diagnose pathological state of thyroid gland; at deviation of Si value within 0.023-0.029 Hz being above normative value one should diagnose pathological state of sympathoadrenal system; at deviation of Si value within 0.031-0.035 Hz being above normative value one should diagnose pathological state in the system of steroid hormones; at deviation of Si value within 0.039-0.041 Hz being above normative value one should diagnose pathological state of baroreceptors of aortic arch; at deviation of Si value within 0.044-0.048 Hz being above normative value one should diagnose pathological state of cervical ganglia of ANS; at deviation of Si value within 0.25-0.35 Hz being above normative value one should diagnose pathological state of vago-insular apparatus in case of exogenous intoxications. The innovation widens the number of means of quick-test diagnostics of human pathological states.
EFFECT: higher efficiency of diagnostics.
1 cl, 2 dwg, 1 tbl
FIELD: medicine, cardiology.
SUBSTANCE: it is necessary to register multiple electrocardiographic signals from anterior (a) thoracic wall, detect amplitude values of Q and R waves to plot two-dimensional maps of Q wave duration (Qa), determine on maps Qa areas at wave Q duration being equal or above 0.04 sec. Moreover, additionally, one should register electrocardiographic potentials from lateral, posterior and diaphragmatic walls, plot two-dimensional maps for distributing the sum of amplitude values of a triple Q wave and R wave (Q3R) in every lead; on Q3R maps one should detect the areas of negative values. In case of both areas in precardiac region one should diagnose anterior Q-myocardial infarction (Q-MI) of left ventricle, in median-inferior departments of right half of thorax - posterior Q-MI and in inferior departments of thorax - diaphragmatic Q-MI. The innovation enables to detect lesion localization more accurately based upon the data of mapping a patient's cardiac surface.
EFFECT: higher accuracy of diagnostics.
6 dwg, 2 ex
SUBSTANCE: method involves recording electrocardiogram signals. Pulse parameters and their synchronized variations are determined. 10 R-R intervals are recorded and their durations are measured, the number of intervals of equal duration KR-R is determined, indexing KR-R duration. Intervals durations being from 530 to 750 ms in initial state, 550-720 ms under light loading, 560-720 ms under heavy loading, satisfactory cardiovascular system adaptation state is stated. The durations deviating by 20-25%, adaptation responses are considered to be under stress. The deviations being equal to 30% and higher, adaptation responses are considered to be under overstress. Interval durations becoming shorter in approaching 300 ms and KR-R ≥2 at the same time, heart fibrillation readiness is considered to be the case.
EFFECT: simplified and accelerated method applicable in static and dynamic mode; enhanced effectiveness in prescribing prophylaxis procedures for preventing sudden death occurrence.
SUBSTANCE: method involves measuring hemodynamic parameters of organism. Slow cardiac rhythm oscillations are recorded before beginning the treatment. Wave frequencies are recorded in bandwidths of UVLF 0.025 Hz, VLF0.026-0.075 Hz, LF 0.076-0.15 Hz, HF 0.16-0.5 Hz, with spectral analysis being done and spectral power density and cardiac rhythm variability power density being determined next in said bandwidth intervals. Total spectral cardiac rhythm power in the intervals is calculated and cardiac rhythm spectrum power per cent distribution of said frequency bandwidth ranges in cardiac rhythm spectrum. Therapy is administered using one of antihypertensive drug groups. Slow cardiac rhythm oscillations are recorded and analyzed 2 weeks later in the same frequency bandwidths. 1 measurement unit of value under study / Hz is taken for 1 point. Total spectral cardiac rhythm power density being evaluated in 30-120 points, cardiac rhythm variability power density being evaluated in 16-60 points in HF bandwidth, LF - 12-61 points, VLF - 6-19 points UVLF - 1-7 points, oscillation power spectrum density per cent distribution within cardiac rhythm spectrum being evaluated as follows: HF - 31-55%, LF - 26-43%, VLF - 11-22%, UVLF - 2-7%, effective treatment is considered to be the case. Cardiac rhythm variability power deviation from the values of frequency bandwidth HF - 16-60 points in, LF - 12-61points, VLF - 6-19 points UVLF - 1-7 points, towards increase or reduction and when oscillations spectrum power density per cent distribution inside of said cardiac rhythm spectrum from the values of HF - 31-55%, LF - 26-43%, VLF - 11-22%, UVLF - 2-7%, the treatment is considered to be to be ineffective and prescribed drug dose is increased, combined therapy is advised, or and antihypertensive drug group is changed.
EFFECT: high accuracy and accelerated evaluation method.
3 tbl, 3 ex
SUBSTANCE: method involves continuously recording electrocardiogram data, R-R interval lengths data are compared using scatterogram under loading. The loads are increased stage-by-stage. Visual diagnostic is carried out by comparing initial scatterogram and each of the loading scatterograms to ones characterizing normal state. If initial state scatterogram is adjacent to coordinate plane center and is displacing along bisector line as dense cloud dilating upwards under loading, norm is to be diagnosed. If initial state scatterogram has found its place in left lower part of the quadrant and its localization does not change under loading, functional disorder of the central nervous system is to be diagnosed.
EFFECT: high accuracy of diagnosis.
6 dwg, 6 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves filtering cardiosignal, digitizing it in time, forming threshold levels and comparing each digitized reading to the threshold levels. The number of readings taken in turn between the threshold levels is counted. The counting result reaching value of n, reference point of n-th discrete electric cardiosignal reading of the cardiocycle next in turn is taken for start point on time axis. Discrete readings coming out of the threshold levels earlier than given number of n is reached in counting, the counting restarts from zero. To determine count number of n, two additional threshold levels are formed. One of them is set above zero line at half T-tooth amplitude value and the other one at the same value below the zero line. Each discrete electric cardiosignal reading value is compared to given threshold levels and the number of readings selected in turn between the levels is counted. Maximum value of this kind Nm is determined in each cardiocycle. The value of n is set equal to 1/2 Nm. Device has filter, analog commutator, clock pulse oscillator, four comparators, four threshold level sources, four AND-gate circuits, two pulse counters, digital comparator, unit for setting maximum value and multiplier.
EFFECT: high reliability in determining cardiocycle start in arrhythmia and QRS-complex shape variation cases.
2 cl, 4 dwg
SUBSTANCE: method involves determining functional state of chewers by measuring blood circulation in blood vessels of external carotid region and maxillary artery region on the right and left side. Linear blood circulation speed value in the external carotid region being in agreement with age-specific reference value, and asymmetry of linear blood circulation speed readings in maxillary artery region on the right and left side being not less than 30%, temporomandibular joint dysfunction is to be diagnosed. Blood circulation is measured by means of ultrasonic Doppler flowmetry.
EFFECT: high reliability of measurement results; simplified process.
2 cl, 4 tbl