Medicinal composition for preparing intrauterus suppository

FIELD: veterinary science.

SUBSTANCE: invention proposes a composition comprising the following agents, wt.-%: liposomal concentrate emulsion with antibiotic of aminoglycoside class, 28.5-29.8; mother milk, 1.5-2.8; propolis, 2.3-4.2; bee wax, 22.5-24.1; hydrogenated fat, 23.5-25.0; gelatin, 1.5-2.0, and glycerol as an emulsifier, the balance. Suppository based on the proposed composition possesses the prolonged effect, low toxicity and high effectiveness.

EFFECT: improved and valuable medicinal properties of composition.

2 tbl, 4 ex

 

The technical field to which the invention relates.

The invention relates to veterinary medicine, in particular to intrauterine suppositories for the treatment of farm animals.

The level of technology

Known antibacterial containing streptomycin included in liposomes, membrane which is formed on the basis of lecithin (see Vladimir N.A., Ladygina GA, ANCOVA A.I. "Antibiotics", No. 1, 1983, p.23-26).

The disadvantage of this tool is the low efficiency in the treatment of diseases of bacterial etiology.

Famous base for suppositories containing gidrirovannoe cottonseed oil, emulsifier, while it additionally contains gelatin, distilled water, an emulsifier is glycerol in the following ratio of ingredients, wt.%:

Gidrirovannoe cotton oil20-30
Gelatin8-12
Distilled water16-25
The emulsifier is glycerolrest

(see A.S. USSR №1650139, CL AC 9/02, publ. 23.05.1991 year). The disadvantage of this framework for suppositories is low absorbability of the active substance.

The closest in technical essence and the achieved positive effect and making the th authors for the prototype is an antibacterial agent for the treatment of diseases of farm animals, representing emulsion, liposomes incorporating antibiotic class aminoglycosides in an effective amount, while the membrane of liposomes contains lipids extracted from organs and tissues of cattle (see U.S. Pat. Of the Russian Federation No. 2158587, CL AC 9/127, 31/7036, 35/12, OR 31/04, publ. 10.11.2000).

The disadvantage of this antibacterial agent is not sufficiently high prolonged action and a relatively high toxic effect on the body.

Disclosure of inventions

Object of the present invention to provide an intrauterine pessary for the treatment of farm animals with prolonged action, low toxicity and high efficacy of antibiotic therapy, which reduces the time of therapeutic course and the multiplicity of the introduction of suppositories.

The technical result that can be achieved using the present invention is to provide a prolonged action of the product, reducing its toxic effects, effectiveness of antibiotic therapy, including intracellular infection, protection from biodegradation, reduction of terms of therapeutic course and the multiplicity of the introduction of suppositories.

The technical result is achieved by using intrauterine suppositories for farm animals, in which with a liposomal emulsion concentrate with included antibiotic class aminoglycosides in an effective amount, gelatin, emulsifier, which is taken glycerin, while it added Royal jelly, propolis, beeswax, hydrogenated fat in the following ratio of components, wt.%:

The liposomal emulsion concentrate
with antibiotic class aminoglycosides28,5 to 29.8
Royal jelly1,5-2,8
Propolis2,3-4,2
Beeswax22,5-24,1
Hydrogenated fat23,5-25,0
Gelatin1,5-2,0
The emulsifier is glycerolrest

The essence of cooking intrauterine pessary for the treatment of farm animals is as follows.

The container is placed a set number of bases for suppositories, namely, beeswax, hydrogenated fat, gelatin, emulsifier, which is used as the glycerol is heated to a temperature of 35-40°stirring constantly, add the liposomal emulsion concentrate with antibiotic class aminoglycosides, Royal jelly and propolis, the temperature is brought to 45-53°With, carry out a homogenization of the mixture for 25-30 min, about laidout to a temperature of 28-29° With Packed and stored in a refrigerator at a temperature of 4-6°C. Received intrauterine suppositories have the solidification temperature of 29°C, the melting temperature of 36-38°C. Suppositories yellowish-white with low specific smell that is solid at room temperature.

Intrauterine suppositories according to the invention have a prolonged action, low toxicity and high efficacy of antibiotic therapy due to the fact that the liposomal emulsion concentrate provides the opportunity for intracellular drug delivery, increases the validity of antibiotic that prevents its destruction, Royal jelly has bacteriostatic and bactericidal properties, antiviral, antitoxic, tonic and stimulant actions, propolis has antimicrobial, anti-inflammatory, anesthetic actions, strengthens the processes of regeneration and improves the immune status of the animal organism, beeswax, hydrogenated fat, gelatin and the emulsifier is glycerol is a base for suppositories and has a high plasticity (see Kravtsov M.I., Lebedev VI "bee Products", 1995, s).

The implementation of the invention

Examples of specific receiving intrauterine pessary for the treatment of agriculturalanimals.

Example 1. The container is placed, in wt.%, the basis for suppositories, namely: beeswax 20,5, hydrogenated fat 22,5, gelatin 1.0, emulsifier glycerol - rest after the calculation of the ratio of components is heated to a temperature of 25-30°stirring constantly, add the liposomal emulsion concentrate is 25.5 antibiotic class aminoglycosides, Royal jelly 1,0, propolis 2,0, the temperature is brought to 40°With, carry out a homogenization of the mixture for 15 minutes, cooled to a temperature of 25°C.

The resulting base for suppository yellowish color with low specific smell, has a solidification temperature of 15.5°and at room temperature is in the soft state, when tested on animals gave a high therapeutic effect, namely the period of treatment lasting up to 30 days at a multiplicity of the introduction of a suppository up to 3 times per day.

Example 2. Getting the basics for intrauterine pessary carried out analogously to example 1, but the ratio of components, wt.%, take the following quantity:

The liposomal emulsion concentrate
with antibiotic class aminoglycosides28,5
Royal jelly1,5
Propolis2,3/td>
Beeswax22,5
Hydrogenated fat23,5
Gelatin1,5
The emulsifier is glycerolrest

the basis for suppositories is heated to a temperature of 35°with constant stirring, and after the addition of liposomal emulsion concentrate, antibiotic class aminoglycosides, Royal jelly and propolis temperature adjusted to 45°With, carry out a homogenization of the mixture for 25 minutes, cooled to 28°, Packed and stored in a refrigerator at a temperature of 4-6°C.

Received intrauterine suppositories yellowish-white with low specific smell have the solidification temperature of 28°that is solid at room temperature, the melting temperature of 36-38°With, the test showed a high therapeutic effect, namely the duration of treatment has decreased significantly up to 5 days at a multiplicity of the introduction of a suppository 1 time per day.

Example 3. Getting the basics for intrauterine pessary carried out analogously to examples 1, 2, but the ratio of components, wt.%, take the following quantity:

The liposomal emulsion concentrate
with antibiotic class aminol is chosidow 29,8
Royal jelly2,8
Propolis4,2
Beeswax24,1
Hydrogenated fat25,0
Gelatin2,0
The emulsifier is glycerolrest

the basis for suppositories is heated to a temperature of 40°with constant stirring, and after the addition of liposomal emulsion concentrate antibiotic class aminoglycosides, Royal jelly and propolis temperature was adjusted to 53°With, carry out a homogenization of the mixture for 30 minutes, cooled to a temperature of 29°, Packed and stored in a refrigerator at a temperature of 4-6°C.

Received suppositories, as well as in example 3, yellowish-white, with low specific smell, have the solidification temperature of 29°remain solid at room temperature, the melting temperature of 36-38°when the test also showed a short term treatment - up to 5 days at a multiplicity of the introduction of a suppository up to 1 times per day, lack of toxicity.

Example 4. Receiving bases for suppositories carried out analogously to examples 1, 2, 3, but the ratio of components, wt.%, take the following quantity:

The liposomal emulsion concentrate
with antibiotic class aminoglycosides30,0
Royal jelly3,0
Propolis5,0
Beeswax25,0
Hydrogenated fat25,5
Gelatin2,5
The emulsifier is glycerolrest

the basis for suppositories is heated to a temperature of 50°with constant stirring and, after the addition of liposomal emulsion concentrate with antibiotic class aminoglycosides, Royal jelly and propolis temperature is brought up to 57°With, carry out a homogenization of the mixture for 30 minutes, cooled to a temperature of 30°C.

Received suppositories, as well as in example 3, yellowish-white, with low specific smell, have the solidification temperature of 29°remain solid at room temperature, the melting temperature of 36-38°when the test also showed a short term treatment - up to 5 days at a multiplicity of the introduction of a suppository up to 1 times per day, lack of toxicity, but increased consumption of components, there has been a rise in the cost of the drug.

Thus, the optimal are the examples 2 and 3, since p is obtained intrauterine suppositories test showed a high therapeutic effect and multiplicity of the suppository. The results are given in tables 1, 2. Table 1 gives the results of treatment with furazolidone suppository, and in table 2 according to the invention.

Table 1
No. p.View animalQty belly., goalsThe duration of treatment, daysMultiplicity ofQuantity wisdom. animal.Effective. treatment, %
1.Cattle233051773,9

Table 2
No. p.View animalQty animal., goalsThe duration of treatment, daysMultiplicity ofQuantity wisdom. animal.Effect. treatment, %
1Cattle215120for 95.2

The present invention in comparison with the prototype and other known technical solution has the following advantages:

- ensuring prolonged action suppository due to the inclusion of liposomal emulsion concentrate;

- reduction of toxic effects;

- improving the efficiency of antibiotic therapy, including intracellular infection, due to targeted delivery of the drug to the pathogen;

- shorter time to therapeutic course and the multiplicity of the introduction of a suppository;

- the safety of the suppository from biodegradation.

Medicinal composition for the preparation of intrauterine suppositories, characterized in that it contains a liposomal emulsion concentrate with antibiotic class aminoglycosides, Royal jelly, propolis, beeswax, hydrogenated fat, gelatin and emulsifier glycerol in the following ratio, wt.%:

the liposomal emulsion
concentrate antibiotic
class aminoglycosides28,5 to 29.8
Royal jelly1,5-2,8
propolis2,3-4,2
beeswax22,5-24,1
hydrogenated fat23,5-25,0
gelatin1,5-2,0
the emulsifier is glycerolrest



 

Same patents:
Vaginal suppository // 2320319

FIELD: medicine, gynecology, pharmacy.

SUBSTANCE: invention relates to preparing vaginal suppositories containing laevomycetin and metronidazol as antibacterial components, pernisolon as an anti-inflammatory component, and cacao butter and lanolin as filling agents wherein these components are taken in the following ratio, g: laevomycetin, 0.25 ± 0.01; metronidazol, 0.25 ± 0.01; nystatin, 0.0625 ± 0.0025, or 250000 ± 10000 U; prednisolone, 0.003; cacao butter, 2 ± 0.2, and lanolin 0.05. Proposed suppository possesses the enhanced effectiveness against mixed infections of lower regions of female reproductive sphere and providing increasing remission period of disease.

EFFECT: improved and valuable medicinal properties of suppository, enhanced effectiveness of treatment.

1 tbl, 4 ex

FIELD: biotechnology, pharmacy.

SUBSTANCE: invention relates to creature of a interferon-base solution for injections and to recombinant strains of Escherichia coli (E. coli) and plasmids for its preparing. Invention proposes a novel recombinant multicopy plasmid DNA pSX50 that encodes synthesis of human leukocyte alpha-2b-interferon expression of that is under control of lactose and tryptophan promoters and transcription terminator. The strain E. coli SX50 as a producer of human recombinant leukocyte alpha-2b-interferon with productivity up to 0.901.0 g of alpha-2b interferon is obtained by transformation of the recipient strain E. coli BL21 cells with recombinant plasmid DNA pSX50. Method for preparing recombinant alpha-2b interferon is based on using the created recombinant strain E. coli SX50 and involving its submerged culturing on nutrient medium with decreased content of tryptophan and at continuous addition of nutrient substrates in the process of biosynthesis. The method involves mechanical destruction of microbial cells under high pressure, dissolving precipitated protein in the concentrated solution of guanidine hydrochloride followed by renaturation of interferon in physiological buffer solutions in the presence of chaotropic agents and its purification using three-step chromatography purification of interferon on resins of type Chelating Sepharose Fast Flow immobilized with Cu2+ ions, ion-exchange chromatography on ion-exchange resins of type CM Sepharose Fast Flow and gel-filtration chromatography on resins of type Superdex-75. Three-step chromatography purification of interferon provides preparing interferon substance of purity above 98% by data of electrophoresis under reducing and non-reducing conditions, and above 95% by data RF HPLC, and this interferon substance doesn't contain pyrogenes (LAL-test). The yield of the end product is 400 mg from 1 l of cultural medium, not less. Invention provides enhancing yield of interferon and stability of its solution.

EFFECT: improved preparing method of interferon.

12 cl, 5 tbl, 6 dwg, 2 ex

FIELD: medicine, gynecology, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to development of vaginal suppository used for dilation of uterus cervix. Agent for dilation of uterus cervix is made as vaginal suppository and comprises Japanese or sugary laminaria micronized powder of particles size 200 mmc, not above, and in the ratio of active substance to suppository base = 1:1 and wherein Vitepsol H15 or Supacir are used as suppository base. Suppository is used in complex therapy for dilation of uterus cervix or in carrying out monotherapy and represents safety and effective method for dilation of uterus cervix.

EFFECT: improved and valuable medicinal properties of agent.

4 ex

Antibacterial agent // 2318523

FIELD: medicine, chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to an antibacterial agent as a suppository containing iodine and designated for treatment of inflammatory diseases of female genital region. Agent prepared as a suppository and containing iodine as an active substance and a filling agent comprises active substance as a complex of iodine-DMSO (dimethylsulfoxide) taken in the ratio = 1:(1-10) wherein it contains a fat-soluble base as a filling agent and wherein the content of iodine is 10 mg. Proposed suppository shows broad spectrum of antibacterial effect and without adverse effect. Active substance penetrates into deep tissues and shows selective effect on microorganisms. The claimed agent is suitable for using and it doesn't pollute skin and dress.

EFFECT: improved and valuable properties of agent.

5 cl, 2 tbl, 5 ex

FIELD: medicine, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to suppository used in treatment of genital condylomae and neoplastic diseases of reproductive organs. Agent for treatment of genital condylomae and neoplastic diseases of reproductive organs as a suppository comprises metindol (3,3'-diindolylmethane) as an active component, lipophilic base containing solid confectionary fat, polyvinylpyrrolidone and butylhydroxyanisole taken in the definite ratio. Proposed agent promotes to effective treatment of genital condylomae and neoplastic diseases of reproductive organs.

EFFECT: valuable medicinal properties of suppository.

2 cl, 4 dwg, 1 tbl, 5 ex

Anti-viral agent // 2316320

FIELD: pharmaceutical industry, in particular agents for viral disease treatment including HIV infection (AIDS and HIV-associated diseases).

SUBSTANCE: claimed agent in form of suppository contains per one 2 g suppository Fullevir (fullerenopolyaminocaproic acid sodium salt) 20 mg as active ingredient and ancillary substances such as propylene glycol 200 mg and balance: Vitepsol.

EFFECT: effective agent having no adverse influence on peripheral blood and body systems.

FIELD: pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to producing interferon-containing suppositories. Interferon-containing suppository comprises a fatty base, emulsifier and human lyophilized interferon purified from low-molecular and high-molecular components of the definite antiviral activity. Mixture of mono-, di- and triglycerides and saturated fatty acids from coconut oil and palm oil of sort "Vitepsol" H-15 and W-35 taken in equal ratio are used as a fatty base. Distilled monoglycerides taken in the definite ratio are used as an emulsifier. Above describes suppositories retain specific activity and effectiveness in treatment of viral and bacterial diseases for a long time and show stability against mechanical effects.

EFFECT: improved and valuable properties of suppository.

1 tbl, 1 ex

FIELD: chemical-and pharmaceutical industry.

SUBSTANCE: claimed agent contains DNA sodium salt isolated from bovine testis and is useful in peroral application in form of powder, tablets, pellets, and capsules for treatment and prophylaxis of anemia, secondary immunodeficit conditions and as bracing agent. Agent may additionally contains biologically active components and filler.

EFFECT: effective and convenient agent having antianemic, immunomodulating and adaptogenic actions.

3 cl, 3 ex, 6 tbl

FIELD: medicine, chemical-pharmaceutical industry, homeopathy, gynecology.

SUBSTANCE: invention relates to creature of novel vaginal homeopathic suppository that can be used in treatment of female genitals. Invention proposes nine variants of homeopathic suppository containing sea-buckthorn oil, homeopathic oily extract, oils and homeopathic essences. Proposed suppositories possess the enhanced bioavailability based on addition of homeopathic oily extract in the prescription, improve regenerative function of organs and tissues and enhance effect of basic components that allows their using in homeopathy in treatment of fungal colpitis, vulvovaginitis, endometriosis and papillomas.

EFFECT: improved and valuable medicinal properties of suppository.

9 cl, 20 ex

FIELD: medicine, pharmaceutical industry.

SUBSTANCE: the present innovation deals with developing new medicinal preparations for treating urogenital diseases. The suggested preparation for treating prostatic diseases designed as a suppository that contains the complex of bioregulatory peptides of cattle prostate as a powder with the content of water-soluble peptides being 20%, not less and the foundation, moreover, antimicrobial preparation being the antibiotic or anti-viral preparation, or anti-protozoan preparation, or the mixture of antibiotic and anti-protozoan preparation taken at 1:1 ratio, or the mixture of anti-viral and anti-protozoan preparation taken at 1:1 ratio and the foundation at the following ratio of the components, g/suppository: complex of bioregulatory peptides of cattle prostate 0.05-0.4; antimicrobial preparation 0.7, not more; the foundation - sufficient quantity to obtain the suppository of 2.15-2.35 g weight. The suggested preparation in the form of suppository is of high level of organotropic activity and high level of antimicrobial action that enables to implement etiotropic and pathogenetic therapy of bacterial prostatitis. The innovation provides the action upon an agent and all pathological processes in the affected organ. The innovation enables to treat bacterial prostatic inflammation and that of functionally associated organs.

EFFECT: higher efficiency of therapy.

4 cl, 132 ex, 32 tbl

FIELD: medicine, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to a composition used for healing wounds and a method for treatment using this composition. Proposed composition comprises the following components, g/1 kg: cyanocobalamine, 4.9-5.1; propolis oily extract, 4.9-5.1; vinylinum, 170-200; low-molecular polyvinylpyrrolidone, 18-22; dimethylsulfoxide, 50-51, and glycerol, 500-550. Method involves applying the dressing material comprising a textile napkin with a region of depot-system of medicinal preparations. Depot-system has holes and comprises cyanocobalamine, propolis oily extract, vinylinum, low-molecular polyvinylpyrrolidone, dimethylsulfoxide and glycerol. Bindings are carried out as pollution of perforative holes. Using the proposed methods promotes to rapid cleansing and healing a suppurative wound. The composition possess the more expressed antibacterial effect, it doesn't cause adverse effects in treatment and expands assortment of medicinal agent for their applying on dressing materials.

EFFECT: improved, enhanced and valuable medicinal properties of composition.

3 cl, 5 ex

FIELD: medicine.

SUBSTANCE: it is necessary to activate a bee before putting it onto a certain skin part due to wetting this skin part with distilled water at the content of dry bee poison ranged 0.8-1.2 mg/8 ml water. The innovation provides acceleration and higher reliability of the above-mentioned procedure despite a bee's state.

EFFECT: higher efficiency of therapy.

1 tbl

FIELD: medicine.

SUBSTANCE: method involves applying three courses of apitoxitherapy given every other day. One bee sting is given in one session at the first and the third day, two bee stings are given at the fifth and the seventh day, three bee stings are given at the ninth and eleventh day, four bee stings are given at the thirteenth and fifteenth day, five bee stings are given at the seventeenth and nineteenth day at the first treatment course. The second treatment course is given later after 3-4 days long pause. Two bee stings are given at the first and the third day, three bee stings are given at the fifth and the seventh day. Four bee stings are given at the ninth and eleventh day. Five bee stings are given at the thirteenth and fifteenth day. Six bee stings are given at the seventeenth and nineteenth day. The third treatment course is given later after 3-4 days long pause. Three bee stings are given at the first and the third day, four bee stings are given at the fifth and the seventh day. Five bee stings are given at the ninth and eleventh day. Six bee stings are given at the thirteenth and fifteenth day. Seven bee stings are given at the seventeenth and nineteenth day.

EFFECT: reduced treatment laboriousness; prevented allergic response occurrence.

FIELD: medicine.

SUBSTANCE: method involves carrying out initial and dynamical neurophysiologic study by applying electroneuromyography approach. The following parameters are taken into account: amplitude and latent period of muscle fiber M-response; nerve impulse conduction speed along nerve; minimum latent period and F-wave dispersion. Combined MT stimulation is carried out according to following algorithm. Spinal cord injury being the case, MT stimulation is carried out on dorsal trunk surface and extremity having proximal position higher and lower with respect to injury place. Then, MT stimulation of distal parts of both legs and at last, MT stimulation of the injury focus projection zone. Brain injury being the case, head and neck MT stimulation is carried out, then dorsal trunk surface MT stimulation is carried out and at last, distal parts of upper and lower extremities MT stimulation is carried out. Stimulation is carried out by applying MT acupressure. Then, each skin area of selected MT is treated with biogenic stimulator elixir according to mentioned algorithm and held 20-30 min long.

EFFECT: considerably activated lost motor functions.

5 cl, 4 tbl

FIELD: medicine.

SUBSTANCE: invention relates to a preparation used in treatment of mycosis and suppurative infections in animals and humans. The preparation represents propolis 10% alcoholic tincture containing additionally ichthyol in the concentration 8-12% of solution volume. Composition consisting of propolis alcoholic extract and ichthyol is used topically with break for 0.5-1 day. Invention provides enhancing effectiveness in treatment of mycosis complicated by suppurative infection and to reduce treatment period.

EFFECT: enhanced and valuable medicinal properties of preparation.

4 tbl, 2 ex

FIELD: cosmetology.

SUBSTANCE: invention proposes a biologically active supplement for cosmetic article that comprises the following components, wt.-%: extract from crustacean Artemia salina vital forms, 20-40; extract after processing cedar nut products, 20-40, and propolis extract, 20-40. Indicated composition is added to cosmetic articles in the concentration 0.5-10%. The biologically active supplement for cosmetic articles represents a balanced complex of natural substances designated for intense care for wilting skin and for retaining skin youthfulness.

EFFECT: valuable biological properties of supplement.

8 cl, 3 ex

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with collecting drone bees' larvae during preimaginal phase into a sterile vial. Then they should be poured with 40%-ethanol at the ratio of 1 portion of alcohol and 9 portions of drone bees' larvae to be frozen for about 23.5-24 h and defrosted for 5-10 min at (+38; +40)°C and homogenized. Homogenizate should be treated with ultrasound at maximal power of 400 W, current of 0.7 A and frequency of 35 kHz at exposure being 5 min to be then supplemented with stabilizing medium at the ratio of 1 portion of homogenizate suspension and 9 portions of 5%-glucose solution and rifampicin at the ratio of 30 mg/l homogenizate suspension. Then the preparation obtained should be packed into sterile vials followed by freeze drying. Moreover, freeze drying should be fulfilled at preliminary freezing at (-40; -45°)C for about 12-14 h followed by freeze drying at creating vacuum of 5-8 mV, not less and heating up to (+44; +45)°C. To finish drying one should fulfill this procedure at preparation's temperature being (+22; +24)°C. The innovation enables to obtain high-efficiency preparation being of no allergic action and prolonged terms of storage.

EFFECT: higher efficiency.

1 cl, 5 ex, 1 tbl

FIELD: veterinary medicine.

SUBSTANCE: into dorsal lumbar muscles being from the left and from the right against vertebral column in area between the last thoracic and the first lumbar vertebrae one should introduce per a half dosage at 0.04-0.06 ml/kg animal's body weight a biogenic stimulant that contains, g (weight%): emulsion out of tissues and organs of fresh water mollusks Anodonta cygnaea 5.0 (37.3), fresh natural bee honey 3.0 (22.4), 10%-lidocaine hydrochloride solution 2.0 (15.0), caffeine-sodium benzoate 1.5 (11.2), potassium iodide 1.5 (11.2), ACD f-2 0.3 (2.2), formalin 0.1 (0.7). The innovation enables to obtain high curative effect.

EFFECT: higher efficiency of therapy.

FIELD: veterinary medicine.

SUBSTANCE: one should inject into dorsal lumbar muscles from the right and from the left against vertebral column per a half-dosage of medicinal preparation that contains the emulsion out of tissues and organs of Black Sea mussels, natural liquid bee honey, 10%-lidocaine hydrochloride solution, potassium iodide, ACD f-2 and formalin at 0.04-0.06 ml/kg body weight at the following ratio of components, g (weight%): emulsion out of tissues and organs of Black Sea mussels 6.0 (41.0), natural liquid bee honey 3.5 (24.0), 10%-lidocaine hydrochloride solution 2.5 (17.1), potassium iodide 2.0 (13.8), ACD f-2 0.5 (3.4), formalin 0.1 (0.7). The innovation enables to activate protective functions of animal body.

EFFECT: higher accuracy and efficiency.

FIELD: medicine, chemical-pharmaceutical and food processing industry.

SUBSTANCE: invention relates to producing liquid medicinal agents and biologically active supplements from vegetable raw. Composition of components for preparing balsam possessing the general tonic effect represents a mixture of natural honey and two aqueous-alcoholic tinctures. The first tincture is prepared from common marjoram herb, Saint-John's-wort herb, peppermint herb, common motherwort herb and purple coneflower herb, common oak bark, pot-marigold flowers and small-leaved linden flowers, blood-red haw-thorn fruits and wild rose fruits using 50% and 40% ethyl alcohol. The second tincture is prepared from common anise fruits and fragrant dill seeds, medicinal valerian rhizomes with roots, creeping wheat-grass and pink rosewort using 70% and 40% ethyl alcohol, and the composition contains components taken in the definite ratio and represents a 40% tincture. Composition is used in aims for normalization and improvement of human body functional state, in prophylaxis of catarrhal, infectious, cardiovascular, urolithiasis and cholelithiasis diseases and in diseases of upper respiratory airways. Balsam promotes to improving the basic metabolic processes, regulates and normalizes activity of digestive tract, enhances elimination of heavy metals, toxic substances from body, reduces symptoms of allergic diseases, accelerates regeneration and adaptability of tissue in transplantation.

EFFECT: improved, enhanced and valuable properties of composition.

1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: method involves introducing ozonized physiologic saline once a day during 30 min in addition to traditionally applied drugs. The ozonized solution has ozone in concentration of 100-150 mcg/l in the amount of 100-150 ml when treating children younger than 3 years. Children being elder then 3 years, ozone concentration is 200-250 mcg/l, its amount is 200-250 ml. The total therapy course is 5 days long. The traditionally applied drugs are not to be used within 30 min before and after ozonized physiologic saline application.

EFFECT: accelerated treatment course; no antibiotics being used; reduced risk of adverse side effects.

1 tbl

Up!