Agent for dilation of uterus cervix based on medicinal vegetable raw

FIELD: medicine, gynecology, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to development of vaginal suppository used for dilation of uterus cervix. Agent for dilation of uterus cervix is made as vaginal suppository and comprises Japanese or sugary laminaria micronized powder of particles size 200 mmc, not above, and in the ratio of active substance to suppository base = 1:1 and wherein Vitepsol H15 or Supacir are used as suppository base. Suppository is used in complex therapy for dilation of uterus cervix or in carrying out monotherapy and represents safety and effective method for dilation of uterus cervix.

EFFECT: improved and valuable medicinal properties of agent.

4 ex

 

The invention consists in the creation of vaginal suppositories for cervical dilatation on the basis of pre-micronized thalli Japanese Kelp (Laminaria japonica) or Kelp sugary (Laminaria saccharina). The technical result is to simplify the introduction of Kelp sugary or Japanese in the lumen of the cervix and direct impact on the cervical epithelium.

It is known that laminaria thallus as extender cervical currently used in the form of sticks. This method is described and patented Voskoboinikova G.M. and Golijanin R.S. (1995). Sticks are made from kelp on a specific technology. The technological process is quite complicated: the stalks are selected based on standards (they should be equal, not less than 15 cm), then stalks of kelp washed with water (water temperature should not exceed +14° (C)stretch at the pointed metal pins mounted on wooden frames (stretch trunks must be very careful to avoid bending parts), then they are stitched with thread made of silk or polyester, dried, cut into slices the ingot, mechanically processed, and prepared for packaging and packaged. In addition to the complexity of the production of chopsticks from kelp, using them is also quite difficult and painful,because once you need to enter a few rods, and each subsequent rod is inserted parallel to the previous and adheres to in the introduction about 15 seconds to prevent ejection from the cervical canal due to contractions of the uterus. Secondly, the introduction of laminaria sticks equates to surgery and is performed only in a hospital environment by qualified personnel. The present invention is the creation of vaginal suppositories based on micronized laminaria thalli Japanese or sugary while the above disadvantages are eliminated. First, raw materials for the micronisation can take any size and, accordingly, the production can be waste-free. Secondly, the introduction of a vaginal suppository is much easier and does not equate to a surgical procedure, this procedure can be carried out very patient. Thirdly, the process of manufacture of suppositories regulated GF and easier performance than the production of chopsticks. Fourthly, standardization suppositories being strictly for the GF, and sticks from kelp strict standards are not.

This goal is achieved in the following way: for cervical dilatation proposed tool - suppositories-based micronized laminaria blades with haristoy or Japanese.

The method is carried out by micronisation of laminaria blades sugary or Japanese to particle size of not more than 200 MMK, followed by the introduction of the mass in the molten suppozitornyj basis. At the same time as suppozitornoj bases used Witepsol or Spacer NaS-50.

Example 1. 0.1 g of a powder of laminaria blades Japanese added to 0.1 g of pre-melted in a water bath (50-60° (C) suppozitornyj basis Spacer Nas-50 add 0,006 grams of Na benzoate, homogenize. Suppositories are produced by pouring into molds. Forms are placed in the freezer for 20-30 minutes. Thus obtained suppositories fully comply with the requirements of article GF XI "Suppository". Weight 2,

Example 2. 0.1 g of a powder of laminaria blades sugar added to 0.1 g of pre-melted in a water bath (50-60° (C) suppozitornyj basis Spacer Nas-50 add 0,006 grams of Na benzoate, homogenize. Suppositories are produced by pouring into molds. Forms are placed in the freezer for 20-30 minutes. Thus obtained suppositories fully comply with the requirements of article GF XI "Suppository".

Example 3. 0.1 g of a powder of laminaria blades Japanese added to 0.1 g of pre-melted in a water bath (50-60° (C) suppozitornyj the basis of Witepsol and homogenized. Suppositories are produced by pouring in fo the us. Forms are placed in the freezer for 20-30 minutes. Thus obtained suppositories fully comply with the requirements of article GF XI "Suppository". Weight 2,

Example 4. 0.1 g of a powder of laminaria blades sugar added to 0.1 g of pre-melted in a water bath (50-60 t° (C) suppozitornyj the basis of Witepsol and homogenized. Suppositories are produced by pouring into molds. Forms are placed in the freezer for 20-30 minutes. Thus obtained suppositories fully comply with the requirements of article GF XI "Suppository".

The mechanism of action of kelp is that at the first stage, the absorption of fluid from the surrounding tissues. Next, kelp swells, creates a radial pressure on the wall of the cervical canal, resulting in the expansion of the cervix.

But the effect of laminaria blades is not limited to emediately, and has a complex and considerably more complex humoral mechanism. Assume that laminaria thallus induce endogenous synthesis of prostaglandins, which contribute to the softening of the cervix. A. Olund et al. (1984) tend to think of activation of the synthesis of prostaglandins caused by the release of free arachidonic acid from bugei kelp during dilatation. Biochemical examination of biopsies of the cervix p. the following applications bogey from kelp showed a marked reduction in the total concentration of collagen and collagenolytic activity which helps to improve the elasticity of the cervix (A.Jonasson and .Larsson, 1989). With the help of special microsensors registered that Bui from kelp are not only soft gelatinous action on the neck, but also induce nabolese contractions of the uterus and increase the contractile activity of the cervix during dilation (A.Jonasson and .Larsson, 1989).

The use of laminaria blades is a safe and effective method of cervical dilatation in women with servicelink stenosis in the procedure of transplanting the embryo (I.Z.Glatstein et al., 1997), as well as in non-pregnant when diagnostic hysteroscopy (D.E.Townsend and R.Melkonian, 1990), vaginal removal of intrauterine compounds (F.P.Chen et al., 1997), podstawy fibroids (..Goldrath, 1990), when introduced into the uterine cavity of radioactive isotopes for cancer treatment (.R.Ferree et al., 1973; W.J.Peeples et al., 1983; P.P.Kumar and R.R.Good, 1986), as well as other endoscopic interventions. Of side effects in the use of laminaria celebrate mild discomfort or pain that does not require anesthesia, sometimes slight bleeding.

In the manufacture of suppositories with the micronized laminaria thalli were used basis Spacer NaS - 50 (item # 3271/00), the basis Witepsol. The ratio of the powder of laminaria blades and Spacer NaS - 50 1:1 and the ratio of the powder of laminaria blades and Witepsol 1:1.

Biologically active substances extracted from laminaria blades is hot. In the manufacture of suppositories observed stages of preparation technology of suppositories: 1. Weighing 2. Cooking basics - the fusion 3. Filter 4. Preparation of concentrate 5. Preparation suppozitornoj mass 6. Preparation of suppositories.

The main characteristics of suppositories based on micronized laminaria blades.

Description: suppositories based on micronized laminaria blades have the same torpedo-shaped form, smooth surface, have sufficient hardness, on the outer surface and on the cut flakes, sequins and pieces of the framework is not observed, the color of the suppositories from light gray to brown, weight 2,

Deviation of the average weight of 2.0+1.2 percent.

The melting temperature of 30-32°C.

The full deformation of 7.2+0,5 minutes

pH of aqueous extract of 4.5-5.0.

Suppositories are used in complex therapy for cervical dilatation or as monotherapy.

Tool for cervical dilatation, characterized in that it is made in the form of vaginal suppositories and contains micronized powder kelp Japanese or sugary with a particle size of not more than 200 MMK when the ratio of the active substance with suppozitornyj the basis of 1:1, as suppozitornoj bases use Witepsol H15 or Spacer NaS-50.



 

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