Means and method for carrying out chronobiological correction

FIELD: medicine.

SUBSTANCE: means comprises two complexes. Morning complex comprises soft tonic and biostimulating vegetable ingredients and vegetable adaptogen complex. Evening complex comprises soft vegetable ingredients of tranquilizing and sedative action stimulating cellular resources recovery. Beside that, the evening and morning complex comprise vitamins, mineral substances, antioxidants and specific biologically active substances directed to correction of specific organ or system disorders arising as a result of chronic desynchronosis. Method involves applying chronobiological correction means selecting their application time to match individual biorhythm phase peaks.

EFFECT: improved tolerance to transmeridional flight loads.

7 cl

 

The invention relates to medicine and can be used for the correction of desynchronosis functions of various organs and systems of the human body caused by professional and technological factors (travel to another time zone, working the night shift and shifts, living in the circumpolar Arctic regions, chronic disorders of the light mode and sleep and wakefulness), and related health disorders.

One of the most important factors contributing to the deterioration of the health of the modern person is a chronic desynchronosis of various organs and systems of the body due to the mismatch daily (circadian) biorhythms in connection with the impact of such an integral factors of modern life, as transmeridian flights, rotational practices and constant interference factors of the urban environment, leading to chronic sleep and wakefulness. The disruption of natural patterns of jet lag leads to disruption of the processes of recovery of organs and systems, their stress and premature depletion of biological resources that is now regarded as one of the most important predpolozhenij human conditions. With long-term persistence of desynchronosis and the lack of measures for the prevention and correction of, this predpolozhenie condition may is perehoditi in chronic diseases, first of all, nervous, cardiovascular, and endocrine systems.

Now for the prevention and correction of desynchronosis used pharmacological and therapeutic effects, aimed primarily at regulating the nervous and endocrine systems.

Known means and the correction method desynchronosis of the human body caused by air travel to a different time zone (Fairbasa. The features of the temporal adaptation in the flights to the East and the West. The means of correction and prevention of desynchronosis. Theory and practice of physical culture. - 2000. No. 3. -P.6-13). The essence of this approach lies in the use of various physiotherapeutic methods of two-phase correction circuits, including, depending on the state or tonic or sedative in combination with tonic preparations. When sufficiently broad comprehensive approach, this method has several limitations, narrowing the range of its application. Firstly, the means and method are intended solely for the correction of short-term desynchronize caused transmeridian flights, and does not meet the characteristics of chronic desynchronize due to professional or urban factors. Second, these funds are directed only to the correction of the overall structure ZirCAD what's rhythms and do not take into account the peculiarities of individual biorhythms of individual organs and systems. Thirdly, these funds are aimed at improving General biological resistance of the organism and do not consider painful disorders in the organs and systems of the body, developing as a result of chronic desynchronosis.

The present invention is to develop tools chronobiological correction biphasic actions on the basis of vegetative raw materials, vitamins and minerals, taking into account the organotropism manifestations of desynchronosis and how chronobiological correction with the use of tools, which takes into account the peculiarities of individual biorhythms organs and systems.

The task in relation to funds chronobiological correction is solved by the fact that the proposed five options means chronobiological correction of two-phase action based on the five most common organotropic manifestations of desynchronosis: pediatric, cardiovascular, neurological, Hepatology, and joints. All variants of the proposed drug chronobiological correction consists of two complexes. Breakfast includes botanicals soft tonic and biostimulating action and the complex of plant adaptogens, evening complex includes botanicals soft soothing and sedative action and promote the s recovery of cell resources. In addition, morning and evening complexes include vitamins, minerals, antioxidants and specific biologically active substances, aimed at correcting specific organ or systemic disorders, developing as a result of chronic desynchronosis.

The tool chronobiological correction is designed to correct chronic desynchronosis, in the first embodiment is a morning and evening complex, this morning the complex includes spirulina - from 4 to 7%, the roots of Eleutherococcus from 7 to 10%, rhizomes and roots of Rhaponticum - from 7 to 10% of the rhizomes and roots of Angelica - from 7 to 10%, Siberian fir needles from 3 to 5%, nettle leaves - from 7 to 10%, raspberry leaves - 6 to 8%, vitamin C 10%to 15%, vitamin a is from 0.25 to 0.5%, vitamin D3 is from 0.001 to 0.002%, vitamin E - from 3 to 5%, vitamin B1 from 0.3 to 0.7%, vitamin B2 from 0.5 to 1%, vitamin B6 from 0.5 to 1%, vitamin B12 - from 0.0005 to 0.001%, vitamin PP (Niacinamide) - from 5 to 7%, folic acid is from 0.05 to 0.1%, Pantothenic acid, from 1%to 2%, Biotin - 5 to 7%; and the evening complex includes spirulina from 5 to 7%, rhizomes and roots of Valerian - from 7 to 10%, motherwort herb from 5 to 7%, peppermint leaves from 4 to 6%, marjoram from 4 to 6%, burdock root, from 4 to 7%, calendula flowers - from 7 to 10%, calcium 10 to 15%, potassium - from 8 to 10%, magnesium from 8 to 10%, iron 4%to 6%the iodine is from 0.03 to 0.1%, selenium - from 0.01 to 0.02%, zinc from up to 4%, copper, from 0.2 to 0.5%, manganese from 0.2 to 0.5%.

The tool chronobiological correction is designed to correct chronic desynchronosis, the second option is a morning and evening complex, this morning the complex includes the extract of hawthorn fruit - from 20 to 25%, Astragalus root extract - from 15%to 20%, green tea extract is from 5 to 7%, citrus bioflavonoids from 15%to 20%, leaf extract raspberry - from 2 to 5%, blueberry leaf from 2 to 5%, grape seed extract is from 0.2 to 0.5%, vitamin C - 10 to 15%, vitamin a and 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%; and the evening complex includes hawthorn fruit - from 30 to 40%, marigold flowers from 7 to 10%, the grass of Tribulus creeping from 10 to 15%, grass clover - from 8 to 10%, the roots of Burnet - from 7 to 10%, the grass ziziphora from 10 to 15%, motherwort herb - from 6 to 8%, balm leaves - 5 to 7%.

The tool chronobiological correction is designed to correct chronic desynchronosis, by the third variant is a morning and evening complex, this morning the complex includes leaf extract Ginkgo - from 12 to 16%, the leaf extract metalistic Asian - from 15 to 17%, Astragalus root extract - from 7 to 10%, citrus bioflavonoids from 15 to 20%, blueberry leaf from 2 to 5%, Golden root, 2 to 3%, Siberian ginseng root, 2 to 3%, to revise and roots of Rhaponticum - from 2 to 3%, the root of aralia - from 2 to 3%, vitamin C 10%to 15%, vitamin a and 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%; and the evening includes the root of Hedysarum from 6 to 8%, the herb St. John's wort - from 10%to 12%, Angelica root from 8 to 10%, hawthorn fruit from 25%to 30%, the herb Euphrasia drug from 20 to 25%, calendula flowers - from 7 to 10%, chaga - from 7 to 10%.

The tool chronobiological correction is designed to correct chronic desynchronosis, according to the fourth variant is a morning and evening complex, this morning the complex includes an extract of Salsola Collina - from 15%to 20%, the extract of the fruit of restorasi from 15%to 20%, the extract of the herb St. John's wort is 6 to 8%, the extract of Saussurea evolites from 1 to 2%, citrus bioflavonoids from 15%to 20%, leaf extract raspberry - from 2 to 5%, vitamin C 10%to 15%, vitamin a - 0,08 to 0,12%vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%; and the evening complex includes the herb agrimony - from 4 to 6%, the fruits of milk Thistle from 20 to 25%, immortelle flowers - from 20 to 25%, the root of Bupleurum from 12 to 16%, corn silk from 6 to 8%, nettle leaves - 10 to 13%, dandelion root from 8 to 10%.

The tool chronobiological correction is designed to correct chronic desynchronosis, the fifth option is a morning and evening complex, this morning the complex includes citrus bioflavonoids from 8 to 12%, xtract raspberry leaf - from 1 to 2%, vitamin C - from 5 to 7%, vitamin a - 0.04 to 0.06%, vitamin E - from 3 to 5%, glucosamine sulfate from 70 to 80%, manganese from 0.1 to 0.2%, zinc from 0.3 to 0.5%, copper from 0.04 to 0.06%, selenium - from 0.004 to 0.006%; and the evening complex includes the flowers of meadowsweet from 35 to 45%, horsetail grass from 5 to 7%, licorice root from 10 to 15%, the herb cinquefoil - from 18 to 22%, leaves of a black currant - from 2 to 5%, the root of Hedysarum from 3 to 5%, bergenia root - from 4 to 6%, birch leaves from 2 to 5%, the herb is from 2 to 5%.

Inventive ways funds can be obtained in the following way. Solid vegetable raw materials - grass, leaves, roots, flowers, fruits, needles, dried and milled. The obtained powders are mixed until a homogeneous mixture with a particle size of not more than 0.5 mm. To obtain extracts of the plant material is extracted with the conventional method, aqueous extracts subjected to vacuum evaporation, followed by drying. Vitamins and minerals used in the form of dry powders. Vitamin E is used in the form of oil solution. All components are mixed in the stated ratios in mixers. The powder mixture after preparation Packed in gelatin capsules weight of 0.35 to 0.65 g - morning complex and weighing 0.3-0.45 g - evening complex. Thus obtained options means chronobiological correction were produced under n is the rank of biologically active additives (BAA) "Rhythm of health".

The task in relation to the claimed method chronobiological correction is solved in that a method using the chronobiological correction, wherein the reception means is chosen in accordance with the selected peaks of the phases of the individual biorhythms.

The method is as follows. Morning complex tools chronobiological correction in the form of 2 capsules weight of 0.35 to 0.65 g take the morning with a meal, the evening complex number 1 capsules of 0.3-0.45 g take in the evening with meals, while taking their morning Tyand the evening reception Tindetermined by the formula:

Ty=tp+0.5 hours

Tin=(1p+12 hours)0.5 hour,

where tg- the average time the usual arbitrary wakefulness during not less than three days beyond the period of intensive work; the duration of the reception means is from 1 to 12 months.

Prepositional variants funds chronobiological correction provide the desired effect chronobiological correction as follows. First, all variants of the claimed means consist of two complexes. Breakfast includes biologically active substances, which have a mild tonic effect and stimulate energy metabolism in cells. These substances are contained in the same, the plant components, as extracts of green tea and raspberry leaf, Golden root, rhizome and roots of Rhaponticum, the roots of aralia, the roots of Eleutherococcus. The evening complex includes biologically active substances, which have a calming effect and contributing to the processes of repair and regeneration of cells. For this part of the options means includes botanicals such as leaves of lemon balm, Valerian root, herb oregano, motherwort herb, marigold flowers and leaves of bergenia, herb Bupleurum. In the two-phase impacts, carried out on the basis of the calculated peaks and acrophase biorhythms, is achieved exogenous correction and stabilization of biological rhythms, disruption of natural patterns which is the main cause of desynchronosis.

Secondly, all variants of the claimed products contain a wide range of plant adaptogens, such as the roots of Hedysarum, Golden root, rhizome and roots of Rhaponticum, the roots of aralia, the roots of Eleutherococcus, grass ziziphora, agrimonia, the roots of Angelica, which increase nonspecific resistance of cells to various damaging environmental factors, including desynchronize different nature.

Thirdly, each of the options stated means includes specially selected herbal and biologically active substances, which have specifications the ical treatment-and-prophylactic action against major organ manifestations of desynchronosis.

For this part of the funds chronobiological correction in the first embodiment, intended for the correction of chronic desynchronosis, mainly manifested by the reduction of General biological resistance of the organism and development of somatic diseases, included components, such as a multivitamin and multi-mineral complexes, as well as spirulina, nettle leaves, raspberry leaves, fir needles, burdock roots as sources of natural vitamins and mineral compounds with correcting and normalizing effect on all types of currency.

Part of the funds chronobiological correction according to the second variant, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the cardiovascular system, the following components are included with protective properties against heart muscle and blood vessels, as well as normalizing lipid and cholesterol metabolism:

antioxidant vitamin and mineral complex (vitamin a, vitamin C, vitamin E, selenium, bioflavonoids), and the extract of raspberry leaf, Astragalus root extract and extract of hawthorn fruit as a means cardiotonic and vasodilator and anticoagulant actions; extract of green tea herb, Tribulus and grass clover as a means of cap is laurocerasus and antiatherosclerotic actions; motherwort herb as hypotensive and sedative; grape seed extract as antithrombotic agents.

Part of the funds chronobiological correction by the third variant, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the Central nervous system, included ingredients that stimulate the cerebral blood flow, energy metabolism and antioxidant protection of the Central nervous system: leaf extract Ginkgo leaf extract metalistic root extract Astragalus as a means of improving the microcirculation in cerebral vessels; antioxidant vitamin and mineral complex (vitamin a, vitamin C, vitamin E, selenium, bioflavonoids); herb Euphrasia and fruits of hawthorn as a vasodilator and antithrombotic funds; the herb St. John's wort as a mild sedative and antidepressant remedies.

Part of the funds chronobiological correction according to the fourth variant, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the liver and biliary tract includes the following components: antioxidant vitamin and mineral complex (vitamin a, vitamin C, vitamin E, selenium, bioflavonoids); extracts soup, restore the Shi as a hepatoprotective means; extract saussurei, immortelle flowers, corn silk, the roots of Bupleurum and dandelion roots as a choleretic and halucinations complex; an extract of the herb St. John's wort extract, raspberry leaf and nettle leaves as anti-inflammatory drugs.

Part of the funds chronobiological correction according to the fifth variant, intended for the correction of chronic desynchronosis, mainly manifested by disorders of the musculoskeletal system includes the following components: glucosamine sulfate as hondroprotektor; Filipendula herb and licorice as anti-inflammatory drugs; extract, raspberry leaf, margent, copper and herb as a means of stimulating the synthesis of collagen; grass cinquefoil, birch leaves, horsetail herb and currant leaves as a means of normalization of water-salt metabolism; as well as antioxidant vitamin and mineral complex (vitamin a, vitamin C, vitamin E, selenium, bioflavonoids).

Offer options means chronobiological correction, used as adjunctive therapy of diseases involving violation of biorhythms organs and body systems, provide more effective treatment of major diseases, as evidenced by the following examples.

Example 1.

The survey was conducted by the camping on the basis of medical-preventive institution "Sanatorium "Krasnoselskii" (Novosibirsk region). The clinical efficacy of the proposed drug chronobiological correction was studied in patients working shifts at polar oil producing companies. Just was observed 40 people, of which 22 people came up with the main group (General rehabilitation methods+the claimed means in the first embodiment) and 18 people - a control group who received only traditional rehabilitation.

All observed showed signs of chronic desynchronize associated with prolonged stay in the polar day and manifested by insomnia, dyspeptic disorders, fatigue, emotional irritability, and symptoms of immunodeficiency States. As an additional therapy in the study group was selected tool chronobiological correction in the first embodiment, designed for the correction of chronic desynchronosis, mainly manifested by the reduction of General biological resistance of the organism and development of somatic diseases.

The study found that in individuals with somatic manifestations of chronic desynchronize the use of the proposed drug was greatly enhanced clinical effectiveness of standard rehabilitation methods. Thus, among persons who received in addition to basic with the Birmingham rehabilitation of the inventive tool, experienced a more rapid recovery of immune status that were manifested by increased resistance to colds and improving the condition of the respiratory organs in comparison with the control group. In addition, in the main group by the end of the month rehabilitation course there was an increase in the overall tone, reduce fatigue and irritability, as well as recovery sleep. In the control group restore health was much slower.

Example 2.

The study was conducted by the Department of human ecology with a course of occupational diseases of the Novosibirsk State Medical Academy, clinic of occupational pathology of the Novosibirsk research Institute of hygiene health Ministry. The clinical efficacy of the proposed drug chronobiological correction was studied in workers with initial signs of vibration disease. The object of study was not chosen by chance, because at the present time in the etiology of vibration disease very important factor desynchronise impact of anthropogenic factors on the body. And since the main organotropic manifestation of desynchronosis in the development of vibration disease is the defeat of the cardiovascular system, for the study were selected tool chronobiological correction designed for short is ecchi chronic desynchronosis, mainly manifested by disorders of the cardiovascular system.

Just was observed in 72 patients with vibration disease: 32 people came up with the main group of patients which, along with the traditional treatment, received the claimed tool according to the second variant, 40 people - a control group, patients who received only conventional therapy.

The study found that in patients with vibration disease, the use of the proposed drug chronobiological correction was greatly enhanced clinical efficacy of the standard treatment regimen that was confirmed by objective clinical, laboratory and functional methods. So, after a course of inpatient treatment in the main group of patients with vibration disease showed a significant positive clinical effect in the improvement of the General condition, normalization of sleep, normalize and stabilize blood pressure, reduce the frequency and severity of cardialgia and headaches. Patients of the main group after treatment according to the control ECG examinations marked improvement of metabolic processes in the myocardium and the tendency to normalization processes repolarization. In addition, according to the days of the hands and feet marked a significant improvement reovazograficheskie the indicators. A control group of patients significant changes reovazograficheskie and ECG indices were observed. In General, the results confirm that cardiotropic drug therapy in combination with the inventive tool contributes to the correction of cardiotropic manifestations of desynchronosis caused by vibration, which leads to system restore microcirculation and improving General health status in patients with vibration disease.

Example 3.

The study was conducted on the basis of medical-preventive institution "Sanatorium "Krasnoselskii" (Novosibirsk region). The clinical efficacy of the proposed drug chronobiological correction was studied in patients working shifts at polar oil-producing companies, with signs disadaptation liver under conditions of chronic desynchronosis. Just observed 28 people, of which 16 people came up with the main group (a common treatment methods + the inventive tool according to the fourth variant) and 12 patients in the control group received only conventional therapy. Disadaptation violations of the functional state of the liver manifested signs of dyskinesia biliary tract and changes in biochemical parameters of liver, namely a moderate increase in levels of total is th bilirubin, alanine aminotransferase and aspartate aminotransferase. As an additional therapy in the study group was selected tool chronobiological correction is designed to correct chronic desynchronosis, mainly manifested by disorders of the liver and biliary tract.

The treatment results in positive dynamics was noted in both groups. All observed noted the disappearance of pain, nausea, burping, restoring regular bowel movements. The inclusion in the proposed drug therapy made it possible to achieve improvement in 94.4% of cases, which is 19.4% higher than in the control group. In the main group more significantly improved, reflecting the metabolism of bilirubin and decreased activity of transaminases.

In the study group noted a more significant change in the characteristics of bile (according to duodenal intubation): reduction of cholesterol crystals and the absence of C-reactive protein in bile in 16 patients (53.3 percent). Similar changes in the control group detected only in 10 patients (33,3%).

IndicatorsThe main groupThe control group
before the treatmentafter the treatment before the treatmentafter the treatment
The total bilirubin19,1±1,513,0±1,215,9±1,313,4±1,4
The direct bilirubin4,2±1,02,1±1,03,6±1,22,3±1,3
Unconjugated bilirubin14,9±2,112,9±1,313,6±1,613,3±1,1
ALT0,62±0,160,25±0,100,61±0,160,43±0,1
ACT0,41±0,10,27±0,090,35±0,10,32±0,1

In General, the results confirm that medication in combination with the inventive tool contributes to the correction of hepatotropic manifestations of desynchronosis and disadaptation violations of the functional state of the liver.

Example 4.

The study was conducted on the basis of clinical goose the MCSEs No. 25 (Novosibirsk). The clinical efficacy of the proposed drug chronobiological correction was studied among University students in the winter session. Just was observed for 22 persons, 12 of which people came up with the main group (General methods of rehabilitation of+the inventive tool according to a third variant), and 10 people - contact the Aulnay group, received only traditional rehabilitation. All observed prior to the course of recovery were signs of functional dyscirculatory encephalopathy associated with a session desynchronosis: headache, dizziness, noise in the head, confusion, memory impairment, poor overall health and mood, emotional lability. According to radioisotope studies noted a decrease in the total cerebral blood flow and mosaic perfusion different areas of the brain. As an additional therapy in the study group was selected tool chronobiological correction is designed to correct chronic desynchronosis, mainly manifested by disorders of the Central nervous system.

In the rehabilitation measures in both groups was noted positive dynamics. However, the inclusion complex of rehabilitation of the proposed drug has allowed to achieve a more complete and more rapid recovery of function of the Central nervous system. In addition, according to re radioisotope studies there was an increase of total cerebral blood flow by 2.4% and the decrease in patchiness of blood supply to different areas of the brain by 15.3% in the control group - 1,2 and 10.1%, respectively). In General, the results confirm that the re is bilitation events in conjunction with the claimed means chronobiological correction promote a more rapid correction of signs of functional encephalopathy, due to a session desynchronosis.

Example 5.

The study was conducted on the basis of clinical sports school №2 (Novosibirsk). The clinical efficacy of the proposed drug chronobiological correction was studied in athletes-football players whose professional activity is connected with frequent transmeridian flights. Just was observed 36 people, of whom 20 people came up with the main group (General methods of rehabilitation of + the inventive tool for the fifth variant), and 16 people - a control group who received only traditional rehabilitation. All observed prior to the course of recovery were signs of a functional lesion of the knee shown some limited mobility, moderate pain and swelling. As an additional therapy in the study group was selected tool chronobiological correction is designed to correct chronic desynchronosis, mainly manifested by disorders of the musculoskeletal system.

The use of the proposed drug in combination with the traditional methods of rehabilitation has allowed not only greatly improve the portability transmeridian flights, but had a pronounced therapeutic effect against acute articular syndrome, call the data sports injuries against the background of continuous desynchronosis, associated with frequent flights athletes. However, in the control group traditional methods of rehabilitation did not have a significant protective effect in relation to the musculoskeletal system, despite the improvement in General well-being of athletes.

In General, the results obtained suggest that rehabilitation activities in conjunction with the claimed means chronobiological correction contributes to the prevention of exacerbations of articular syndrome caused by chronic desynchronosis.

1. The tool chronobiological correction, representing morning and evening complexes, this morning the complex includes spirulina, the roots of Eleutherococcus, rhizomes and roots of Rhaponticum, rhizomes and roots of Angelica, Siberian fir needles, leaves of a nettle, raspberry leaves, vitamin C, vitamin a, vitamin D3, vitamin E, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin PP (Niacinamide), folic acid, Pantothenic acid, Biotin, and the evening complex includes spirulina, rhizomes and roots of Valerian, motherwort herb, peppermint leaves, marjoram, burdock root, marigold flowers, calcium, potassium, magnesium, iron, iodine, selenium, zinc, copper, manganese in the following ratio, wt.%:

morning complex: spirulina is from 4 to 7%, the roots of Eleutherococcus from 7 to 10%, rhizomes and roots of Leuze is - from 7 to 10%, rhizomes and roots of Angelica-from 7 to 10%, Siberian fir needles from 3 to 5%, nettle leaves - from 7 to 10%, raspberry leaves - 6 to 8%, vitamin C 10%to 15%, vitamin a is from 0.25 to 0.5%, vitamin D3 is from 0.001 to 0.002%, vitamin E - from 3 to 5%, vitamin B1 from 0.3 to 0.7%, vitamin B2 from 0.5 to 1%, vitamin B6 - from 0.5 to 1%, vitamin B12 - from 0.0005 to 0.001%, vitamin PP (Niacinamide) - from 5 to 7%, folic acid is from 0.05 to 0.1%, Pantothenic acid, from 1%to 2%, Biotin - 5 to 7%;

evening complex: spirulina is from 5 to 7%, rhizomes and roots of Valerian - from 7 to 10%, motherwort herb from 5 to 7%, peppermint leaves from 4 to 6%, herb oregano is from 4 to 6%, burdock root, from 4 to 7%, calendula flowers - from 7 to 10%, calcium 10 to 15%, potassium - from 8 to 10%, magnesium from 8 to 10%, iron 4%to 6%, iodine - from 0.03 to 0.1%, selenium - from 0.01 to 0.02%, zinc from 2 to 4%copper, from 0.2 to 0.5%, manganese from 0.2 to 0.5%.

2. The tool chronobiological correction, representing morning and evening complexes, this morning the complex includes the extract of hawthorn fruit, Astragalus root extract, green tea extract, citrus bioflavonoids extract, raspberry leaf, blueberry leaf, grape seed extract, vitamin C, vitamin a, vitamin E, selenium, and the evening complex includes hawthorn fruit, marigold flowers, grass Tribulus creeping, grass, clover, roots of Burnet, grass ziziphora, motherwort herb balm leaves in the following ratio of components, wt.%:

Breakfast: fruit extract hawthorn - from 20 to 25%, Astragalus root extract - from 15%to 20%, green tea extract is from 5 to 7%, citrus bioflavonoids from 15%to 20%, leaf extract raspberry - from 2 to 5%, blueberry leaf from 2 to 5%, grape seed extract is from 0.2 to 0.5%, vitamin C 10%to 15%, vitamin a and 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%;

evening complex: hawthorn fruit - from 30 to 40%, marigold flowers from 7 to 10%herb, Tribulus creeping from 10 to 15%, grass clover - from 8 to 10%, the roots of Burnet - from 7 to 10%, grass ziziphora from 10 to 15%, motherwort herb - from 6 to 8%, balm leaves - 5 to 7%.

3. The tool chronobiological correction, representing morning and evening complexes, this morning the complex includes leaf extract Ginkgo leaf extract metalistic Asian, Astragalus root extract, citrus bioflavonoids, blueberry leaf, Golden root, Siberian ginseng root, rhizome and roots of Rhaponticum, the root of aralia, vitamin C, vitamin a, vitamin E, selenium, and the evening complex includes the root of Hedysarum, the herb St. John's wort, Angelica root, hawthorn fruit, herb Euphrasia drug, marigold flowers, chaga in the following ratio, wt.%:

Breakfast: leaf extract Ginkgo - from 12 to 16%, the extract of the leaves of witalis the nickname Asian - from 15 to 17%, Astragalus root extract-from 7 to 10%, citrus bioflavonoids from 15 to 20%, blueberry leaf from 2 to 5%, Golden root, 2 to 3%, Siberian ginseng root, 2 to 3%, rhizomes and roots of Rhaponticum from 2 to 3%, the root of aralia - from 2 to 3%, vitamin C 10%to 15%, vitamin a and 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%;

evening complex: the root of Hedysarum from 6 to 8%, the herb St. John's wort - from 10%to 12%, Angelica root from 8 to 10%, hawthorn fruit from 25%to 30%, herb Euphrasia drug from 20 to 25%, calendula flowers - from 7 to 10%, chaga - from 7 to 10%.

4. The tool chronobiological correction representing morning and evening complexes, this morning the complex includes an extract of Salsola Collina, fruit extract, milk Thistle, an extract of the herb St. John's wort extract saussurei epolito, citrus bioflavonoids extract, raspberry leaf, vitamin C, vitamin a, vitamin E, selenium; and the evening complex includes the herb agrimony, fruits, milk Thistle, immortelle flowers, the root of Bupleurum, corn silk, nettle leaves, dandelion root in the following ratio, wt.%:

Breakfast: extract of Salsola Collina - from 15 to 20%fruit extract, milk Thistle from 15%to 20%, the extract of the herb St. John's wort is 6 to 8%, the extract of Saussurea evolites from 1 to 2%, citrus bioflavonoids from 15 to 20%extract, raspberry leaf - the t 2 to 5%, vitamin C is from 10 to 15%, vitamin a and 0.08 to 0.12%, vitamin E - from 6 to 10%, selenium - from 0.008 to 0,012%;

evening complex: agrimonia - from 4 to 6%, the fruits of milk Thistle from 20 to 25%, immortelle flowers - from 20 to 25%, the root of Bupleurum from 12 to 16%, corn silk from 6 to 8%, nettle leaves - 10 to 13%, dandelion root from 8 to 10%.

5. The tool chronobiological correction, representing morning and evening complexes, this morning the complex includes citrus bioflavonoids extract, raspberry leaf, vitamin C, vitamin a, vitamin E, glucosamine sulfate, manganese, zinc, copper, selenium; and the evening complex includes the flowers of meadowsweet, horsetail herb, licorice root, herb cinquefoil, leaves of a black currant, the root of Hedysarum, bergenia root, birch leaves, herb in the following ratio, wt.%:

Breakfast: citrus bioflavonoids from 8 to 12%, the extract of raspberry leaves - 1 to 2%; vitamin C from 5 to 7%, vitamin a - 0.04 to 0.06%, vitamin E - from 3 to 5%, glucosamine sulfate from 70 to 80%, manganese from 0.1 to 0.2%, zinc from 0.3 to 0.5%, copper from 0.04 to 0.06%, selenium - from 0.004 to 0.006%;

evening complex: the flowers of meadowsweet from 35 to 45%, horsetail herb from 5 to 7%, licorice root, 10 to 15%, grass cinquefoil - from 18 to 22%, leaves of a black currant - from 2 to 5%, the root of Hedysarum from 3 to 5%, bergenia root from 4 to %, birch leaves from 2 to 5%, herb - from 2 to 5%.

6. The way chronobiological correction, characterized in that morning complex tools chronobiological correction in the form of 2 capsules weight of 0.35 to 0.65 g take the morning with a meal, the evening complex number 1 capsules of 0.3-0.45 g take in the evening with meals, and the morning of The reception and the evening reception TV is determined by the formula:

Ty=tp+0.5 h

Tin=(1p+12 h)-0,5 h

where tp- the average time the usual arbitrary wakefulness during not less than three days beyond the period of intensive work;

the length of time it takes from 1 to 12 months.



 

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6 cl, 3 tbl, 6 ex

FIELD: medicine, veterinary science, agriculture, biotechnology.

SUBSTANCE: the present innovation refers to preparations of medicinal and veterinary indication and methods for their obtaining. The suggested complex preparation-probiotic includes a carrier being a porous aluminum oxide-based enterosorbent SUMS-1 and cells of bacteria-eubiotics with nutritive and protective media immobilized upon the mentioned carrier-enterosorbent. The cells of bacteria-eubiotics with nutritive medium are being a lyophilized concentrate of the consortium of either bifidobacteria or lactobacteria, or their mixture at titer being 108-1010 CFU/g, and as a porous carbon-modified enterosorbent SUMS-1 it contains enterosorbent SUMS-1 additionally treated with the solution of metal salt at the following ratio of the preparation components in lyophilized form, weight%: cells with nutritive medium of the consortium of bifido-, or lactobacteria-eubiotics, or their mixture with titer of 108-1010 CFU/g 1.0-10.0; protective medium 0.1-10.0; enterosorbent SUMS-1 additionally treated with the solution of metal salt - the rest up to 100%. Method for obtaining the suggested preparation deals with treating a porous enterosorbent SUMS-1 with the solution of metal salt at volumetric ratio being 1:1, not more and its washing against a reagent with 2-3-fold volumes of distilled water followed by mixing enetrosorbent and bacteria-eubiotics with nutritive and protective media at the ratio of 1:1, not more to keep the mixture till complete immobilization of bacterial cells onto enterosorbent with its subsequent freezing and freeze drying before sterilization. As bacteria one should apply the concentrate of the consortium of bifidobacteria, or lactobacteria, or their mixture at titer being 108-1010 CFU/g. The suggested complex preparation-probiotic provides higher efficiency of sorption and desorption of bacterial cells with enterosorbent SUMS-1 that shows its clinical efficiency and higher colonization activity of bacteria-eubiotics.

EFFECT: higher efficiency.

9 cl, 5 ex, 2 tbl

FIELD: medicine, surgery.

SUBSTANCE: the present innovation refers to treating osseous cavity in patients with chronic post-traumatic osteomyelitis, so, after necrsequestrectomy one should irrigate an osseous cavity with aqueous solution of sodium chloride, then it is necessary to treat the cavity with 3%-hydrogen peroxide solution with subsequent removal of foam with 0.02%-chlorohexidine bigluconate aqueous solution. Then twice during 1 min it is necessary to treat osseous cavity with 0.9%-ozonized sodium chloride solution at ozone concentration being 9000-10000 mgl/l. After that, one should introduce the mixture of anti-infectious chemotherapeutic preparations along with ultrasound cavitation for 3 min at frequency of 40 kHz followed by treating the cavity with the flow of nitrogen monoxide for 5 min at concentration being 5000 mg/cu. m. The innovation enables to increase penetrating capacity of medicinal preparations due to matching the desired mode of cavitary treatment.

EFFECT: higher efficiency of antiseptic treatment.

1 ex

FIELD: biotechnology, molecular biology.

SUBSTANCE: invention proposes a polynucleotide VEGI-192a encoding polypeptide that inhibits growth of human vascular endothelial cells. Invention describes expressing vector comprising polynucleotide and E. coli cell-host comprising vector. Invention discloses polypeptide encoded by polynucleotide and fused protein based on indicated polypeptide. Invention describes polynucleotide encoding fused protein and expressing vector based on indicated polynucleotide. Invention discloses a pharmaceutical composition used for inhibition of angiogenesis based on polypeptide-inhibitor of growth of human vascular endothelial cells and polynucleotide encoding its. Invention describes therapeutic methods for inhibition of angiogenesis and suppression of tumor growth based on this composition. Invention describes an antibody raised to polypeptide that inhibits growth of human vascular endothelial cells. Using this invention provides novel forms of inhibitor of human growth of vascular endothelial cells and can be used in medicine.

EFFECT: valuable biological and medicinal properties of inhibitor.

27 cl, 27 dwg, 13 tbl, 34 ex

FIELD: medicine.

SUBSTANCE: method involves opening pyo-inflammatory focus. Rexod is introduced in addition to basic therapy. Rexod is introduced during the operation or immediately after the operation and then every day once a day intravenously in bolus dose. The drug is introduced during 4-5 days in physiologic saline or in 5% glucose solution at a dose of 0.2 mcg/kg of patient body weight.

EFFECT: enhanced effectiveness of treatment; improved general health state within a short period; reduced oxidation stress; prevented secondary active oxygen forms production.

3 tbl

FIELD: medicine.

SUBSTANCE: disclosed is application of Ximedon (N-(β-oxyethyl)-4,6-dimethyl-1,2-dihydro-2-oxopyrimidine) for treatment and prophylaxis of various intoxication.

EFFECT: preparation of large spectrum of action and inducing effect comparable with Phenobarbital effect.

2 tbl, 13 ex

FIELD: medicine.

SUBSTANCE: method involves treating root canals with instruments and preparation containing calcium hydroxide is temporarily placed into the canals several times changing the portion every 2-5 weeks for fresh one. Before introducing fresh portion, the root canals are treated with antiseptic solution in combination with their ultrasonic treatment.

EFFECT: enhanced effectiveness of treatment; stopped inflammatory responses in periodontium tissues; prevented reinfection.

8 cl

FIELD: medicine, pulmonology.

SUBSTANCE: it is necessary to study initial values of functional reserve ability (FRA) of pulmonary-capillary circulation in %, average pressure value in pulmonary artery (AvPPA) in mm mercury column and daily variability of peak volumetric expiration rate (ΔPVRexp.) in % to calculate the following equation: D=+1.376·FRA-2.087·AvPPA-1.023·ΔPVRexp. At D value being above -25.71 one should predict instable flow of bronchial asthma. The innovation enables to carry out integral evaluation of functional state of pulmonary microcirculation, pressure in pulmonary artery and reactivity of respiratory tract.

EFFECT: higher efficiency and accuracy of prediction.

2 ex

FIELD: pharmaceutical chemistry.

SUBSTANCE: invention provides water-soluble camptotecine derivatives showing excellent therapeutical activity and retarded release suitable for cancer chemotherapy. High-molecular weight camptotecine derivative has structure wherein carboxylic acid group of block copolymer of polyethylene glycol and polymer containing carboxylic acid group in side chain and being acidic amino acid polymer is linked to phenol hydroxyl group of phenolic camptotecines through ester linkage. Also claimed is high-molecular weight camptotecine derivative of general formula (I): . Preparation method comprises combining carboxylic acid group of above-defined block copolymer with phenol hydroxyl group of phenolic camptotecines through ester linkage in presence of condensation agent. Anticancer drug includes above-defined camptotecine derivative and optionally pharmaceutically acceptable carrier.

EFFECT: augmented choice of anticancer drugs.

9 cl, 2 dwg, 2 tbl, 5 ex

FIELD: medicine, dermatology, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a composition used in treatment and prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals and containing winter-hardy kiwi extract. Also, invention relates to a method for preparing the composition containing winter-hardy kiwi extract and involving diluting milled and dried winter-hardy kiwi with water or lower alcohols, heating a diluted winter-hardy kiwi and extraction of product to obtain winter-hardy kiwi extract. Also, invention relates to a method for treatment, relive or prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals involving administration in a mammal winter-hardy kiwi extract for treatment or prophylaxis of at least one symptom of allergic disease or non-allergic inflammatory disease. Also, invention elates to a method for treatment and prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals involving prescription or administration in mammal winter-hardy kiwi extract for treatment or prophylaxis of at least one symptom of allergic disease or non-allergic inflammatory diseases in mammal. Also, invention relates to using winter-hardy kiwi extract for treatment, relieve or prophylaxis of allergic diseases or non-allergic inflammatory diseases in mammals. Above described winter-hardy kiwi extract and a composition based on thereof show effectiveness in treatment, relieve or prophylaxis of allergic diseases or non-allergic inflammatory diseases in mammals.

EFFECT: valuable medicinal properties of composition.

58 cl, 5 dwg, 11 tbl, 11 ex

FIELD: food or cosmetic biologically active additive, medicine, cosmetic, food processing industry.

SUBSTANCE: claimed additive contains lipid and protein-amino acid fraction from extract of cyst, or nauplii, or adult persons of naxillopod Artemia salina in ratio from 1000:1 to 1:1.

EFFECT: biologically active additive with controlled content of proteins and amino acids and reduced allergenic reactions.

4 tbl, 6 ex

FIELD: plant-based prophylaxis agents.

SUBSTANCE: claimed agent represents two separately administering preparation forms. The first preparation form contains Orthilia secunda grass, marsh cinquefoil grass and roots, elecampane rootstocks and roots, sulla (Hedysarum theinum) rootstocks and roots, milfoil dry extract, vitamins B1 and B6 in specific component ratio. The second form contains Orthilia secunda grass, calendula flowers, knot grass, button roots, tutsan dry extract, vitamins C and E in specific component ratio.

EFFECT: bioactive additive with optimum component composition.

3 cl

FIELD: biotechnology, microbiology.

SUBSTANCE: invention proposes the strain Bifidobacterium adolescentis DVA-2 that that is isolated from the health adult human intestine content and can be multiplied in different nutrient media with accumulation of industrial biomass with the high concentration of bifidobacteria. The strain Bifidobacterium adolescentis DVA-2 possesses acid-forming activity, antagonistic activity with respect to pathogenic and opportunistic microorganisms. Invention provides normalization of microbiocenosis of human body and among them digestive and urogenital tracts, cutaneous and mucosa tissues, and expands assortment of similar agents also.

EFFECT: valuable properties of strain.

2 tbl, 4 ex

FIELD: biotechnology, microbiology.

SUBSTANCE: invention relates to the strain Bifidobacterium longum PO-6 that is isolated from the health adult human intestine content and can be multiplied in different nutrient media with accumulation of industrial biomass with the high concentration of bifidobacteria. The strain Bifidobacterium longum PO-6 possesses acid-forming activity, antagonistic activity with respect to pathogenic and opportunistic microorganisms and ferments milk. Invention provides normalization of microbiocenosis in human body and among them digestive and urogenital tracts, cutaneous and mucosa tissues, and expand assortment of similar agents also.

EFFECT: valuable properties of strain.

5 ex

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a cutaneous antiseptic agent that comprises ethyl alcohol and/or isopropyl alcohol, alkyldimethylbenzyl ammonium chloride, perfume and N,N-bis-(3-aminopropyl)dodecylamine, Trilon B, functional additives and drinking water wherein components are taken in the definite ratio, wt.-%. As functional additives showing a softening effect on skin and stimulating its recover method involves using polyethylene glycol-7 (PEG-7), glycerylcocoate and green tea extract. For elimination of specific odor of agent perfume is added in the ratio 0.28-0.32 wt.-%. Invention provides activity of agent against some pathogens of viral infections and among them against pathogens of viral infections and tuberculosis mycobacteria and with providing possibility for prolonged using antiseptic agent without its negative effect on skin.

EFFECT: improved and valuable medicinal properties of agent.

6 tbl, 1 ex

FIELD: pharmaceutical industries.

SUBSTANCE: claimed agent contains wheat germ oil or wheat germ oil concentrate and microelement complex including zinc and selenium in form of selenospyrane in specific component ratio. Method for production of wheat germ oil includes raw material drying in fluidized bed, two-step cold pressing under specific conditions. Method for production of wheat germ oil concentrate includes double extraction of wheat germ oil with 92-93 % ethanol under specific conditions.

EFFECT: product of increased content of biologically active substances and improved therapeutic action.

4 cl, 9 dwg, 6 tbl, 2 ex

FIELD: chemical and pharmaceutical industry, in particular agents for treatment of skin and mucous inflammatory diseases, trophic ulcer, bed sores.

SUBSTANCE: claimed agent sea-buckthorn oil, thuja oil, calendula tincture, Kalanchoe juice, oily extracts from onion and garlic, aerosyl, emulsifier T2 in specific ratio.

EFFECT: liniment with phytocomplex having increased anti-combustion, wound-healing and anti-inflammatory action.

5 tbl, 4 ex

FIELD: chemical and pharmaceutical industry, in particular agents for treatment of skin and mucous inflammatory diseases, trophic ulcer, bed sores.

SUBSTANCE: claimed agent sea-buckthorn oil, thuja oil, calendula tincture, Kalanchoe juice, oily extracts from onion and garlic, aerosyl, emulsifier T2 in specific ratio.

EFFECT: liniment with phytocomplex having increased anti-combustion, wound-healing and anti-inflammatory action.

5 tbl, 4 ex

FIELD: chemical and pharmaceutical industry, in particular agents for treatment of skin and mucous inflammatory diseases, trophic ulcer, bed sores.

SUBSTANCE: claimed agent sea-buckthorn oil, thuja oil, calendula tincture, Kalanchoe juice, oily extracts from onion and garlic, aerosyl, emulsifier T2 in specific ratio.

EFFECT: liniment with phytocomplex having increased anti-combustion, wound-healing and anti-inflammatory action.

5 tbl, 4 ex

FIELD: medicine, dermatology, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a composition used in treatment and prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals and containing winter-hardy kiwi extract. Also, invention relates to a method for preparing the composition containing winter-hardy kiwi extract and involving diluting milled and dried winter-hardy kiwi with water or lower alcohols, heating a diluted winter-hardy kiwi and extraction of product to obtain winter-hardy kiwi extract. Also, invention relates to a method for treatment, relive or prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals involving administration in a mammal winter-hardy kiwi extract for treatment or prophylaxis of at least one symptom of allergic disease or non-allergic inflammatory disease. Also, invention elates to a method for treatment and prophylaxis of allergic diseases and non-allergic inflammatory diseases in mammals involving prescription or administration in mammal winter-hardy kiwi extract for treatment or prophylaxis of at least one symptom of allergic disease or non-allergic inflammatory diseases in mammal. Also, invention relates to using winter-hardy kiwi extract for treatment, relieve or prophylaxis of allergic diseases or non-allergic inflammatory diseases in mammals. Above described winter-hardy kiwi extract and a composition based on thereof show effectiveness in treatment, relieve or prophylaxis of allergic diseases or non-allergic inflammatory diseases in mammals.

EFFECT: valuable medicinal properties of composition.

58 cl, 5 dwg, 11 tbl, 11 ex

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